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https://www.readbyqxmd.com/read/29145262/management-of-radiation-induced-rectovesical-fistula-in-a-woman-using-ileum-a-case-report-and-review-of-the-literature
#1
Qiqi Mao, Jindan Luo, Jiajie Fang, Hai Jiang
BACKGROUND: Radiation-induced rectovesical fistulas (RVFs) require the most demanding treatment. We presented a rare case of postradiation RVF in a woman repaired with ileum. CASE PRESENTATION: A 49-year-old women was referred to our department for fecaluria and dysuria after radiation for cervical cancer. The voiding cystourethrography demonstrated a large RVF. A segment of ileum was separated into 2 parts for the simultaneous reconstruction of bladder and rectum, which led to a permanently closed fistula...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29142952/serum-ngal-and-cystatin-c-comparison-with-urinary-albumin-to-creatinine-ratio-and-inflammatory-biomarkers-as-early-predictors-of-renal-dysfunction-in-patients-with-type-2-diabetes
#2
Marcelo R Bacci, Ethel Z Chehter, Ligia A Azzalis, Beatriz Costa de Aguiar Alves, Fernando L A Fonseca
Introduction: Diabetic nephropathy is associated with specific histological changes. Early detection of poor glomerular and tubular function can be achieved with biomarkers of diabetes. The aim of this study was to evaluate the accuracy of kidney dysfunction biomarkers in type 2 diabetes (T2D). Methods: Patients with T2D were grouped according to their glycated hemoglobin level. Patients' urine and blood samples were taken to measure cystatin C (CysC), neutrophil gelatinase-associated lipocalin, beta-trace protein levels, and the first morning void albumin-to-creatinine ratio...
March 2017: KI Reports
https://www.readbyqxmd.com/read/29141938/stimulation-of-the-sensory-pudendal-nerve-increases-bladder-capacity-in-the-rat
#3
James A Hokanson, Christopher L Langdale, Arun Sridhar, Warren M Grill
Pudendal nerve stimulation is a promising treatment approach for lower urinary tract dysfunction, including symptoms of overactive bladder. Despite some promising clinical studies, there remain many unknowns as to how best to stimulate the pudendal nerve to maximize therapeutic efficacy. We quantified changes in bladder capacity and voiding efficiency during single-fill cystometry in response to electrical stimulation of the sensory branch of the pudendal nerve in urethane-anesthetized female Wistar rats. Increases in bladder capacity were dependent on both stimulation amplitude and rate...
November 15, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29141931/norethisterone-enanthate-induced-cerebral-venous-sinus-thrombosis-cvst
#4
Mandreker Bahall, Manisha Santlal
A 23-year-old East Indian woman with no significant medical history, except a depot-norethisterone enanthate injection taken 3 weeks prior to admission, presented with a gradually worsening headache for the past 5 days. She had no fever, vomiting, neck stiffness, focal weakness or rash, and examination was unremarkable with no focal neurological deficits. Vasculitic, thrombophilia and sepsis screens were normal. A brain CT scan showed a left parietal lobe venous infarct, secondary to a venous dural sinus thrombosis, with MRI and Magnetic Resonance Venogram (MRV) confirming a signal void...
November 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29140596/florence-robotic-intracorporeal-neobladder-florin-a-new-reconfiguration-strategy-developed-following-the-ideal-guidelines
#5
Andrea Minervini, Davide Vanacore, Gianni Vittori, Martina Milanesi, Agostino Tuccio, Giampaolo Siena, Riccardo Campi, Andrea Mari, Andrea Gavazzi, Marco Carini
OBJECTIVE: To describe our step-by-step technique for robotic intracorporeal neobladder configuration, including the stages of conception, development and exploration of this surgical innovation, according to the IDEAL Collaboration guidelines. PATIENTS AND METHODS: FloRIN neobladder was performed after the following main surgical steps: isolation of 50 cm of ileum; bowel anastomosis; urethro-ileal anastomosis creating an asymmetrical U shape (30 cm distally and 20 cm proximally to anastomosis), ileum detubularisation; posterior wall reconfiguration as an L; bladder neck reconstruction; anterior folding of the posterior plate to reach the 12 o'clock position; uretero-enteral "orthotopic" bilateral anastomosis...
November 15, 2017: BJU International
https://www.readbyqxmd.com/read/29140562/urodynamic-measurements-reflect-physiological-bladder-function-in-rats
#6
Marc P Schneider, Andrea M Sartori, Juliane Tampé, Selina Moors, Anne K Engmann, Benjamin V Ineichen, Anna-Sophie Hofer, Martin E Schwab, Thomas M Kessler
AIMS: Our objective was to investigate and compare bladder function in rats assessed by metabolic cage and by urodynamic measurements in fully awake animals. METHODS: Bladder function of female Lewis rats was investigated in naïve animals by metabolic cage at baseline, 14-16 days after bladder catheter and external urethral sphincter electromyography electrode implantation in fully awake animals by urodynamics, and again by metabolic cage. RESULTS: Investigating the same animals (n = 8), voided volume, average flow, and duration of voiding were similar (P > 0...
November 15, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29139168/hunter-gatherer-dental-pathology-do-historic-accounts-of-aboriginal-australians-correspond-to-the-archeological-record-of-dental-disease
#7
Judith Littleton
OBJECTIVES: Studies of hunter-gatherer oral pathology, particularly in Australia, often focus upon dental wear and caries or assume that historic studies of Aboriginal people reflect the precontact past. Consequently the range of population variation has been underestimated. In this paper dental pathology from human remains from Roonka are compared with a model of dental pathology derived from historic studies. The aim is to identify aspects of dental pathology indicative of regional or intra-population diversity...
November 15, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29137981/umbilical-cord-derived-mesenchymal-stem-cells-alleviated-inflammation-and-inhibited-apoptosis-in-interstitial-cystitis-via-akt-mtor-signaling-pathway
#8
Juncong Xie, Bolong Liu, Jialiang Chen, Yuancheng Xu, Hailun Zhan, Fei Yang, Wenbiao Li, Xiangfu Zhou
Interstitial cystitis (IC) is a bladder syndrome characterized by pelvic pain and urinary frequency without infection or other identifiable pathology. There are no effective treatments to cure IC. This study investigated the effects of human umbilical cord-derived mesenchymal stem cells (UC-MSCs) injection on IC rat model. Furthermore, we used a coculture system to find the possible molecular mechanism on the human uroepithelial cells (SV-HUC-1), which was the cell model of IC. A rat model of IC was established via systemic injection with cyclophosphamide (CYP) and a cell model of IC was induced by being exposed to tumor necrosis factor (TNF)-α (10 ng/ml)...
November 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29136287/quantification-of-mri-visibility-and-artefacts-at-3t-of-liquid-fiducial-marker-in-a-pancreas-tissue-mimicking-phantom
#9
Sergej Schneider, Rasmus Irming Jølck, Esther Gera Cornelia Troost, Aswin Louis Hoffmann
PURPOSE: X-ray based position verification of the target volume in image-guided radiation therapy (IGRT) of patients with pancreatic ductal adenocarcinoma (PDAC) is currently performed on solid fiducial markers that are implanted under endoscopic ultrasonography. A new biodegradable liquid fiducial marker has recently been introduced. To assess its potential use for magnetic resonance imaging (MRI) guided photon or proton radiotherapy of PDAC, the MRI visibility and artefacts of this marker were quantified and compared against solid gold markers...
November 14, 2017: Medical Physics
https://www.readbyqxmd.com/read/29135903/micturition-syncope-in-childhood-how-to-recognize-and-manage-it
#10
Pierluigi Marzuillo, Stefano Guarino, Vincenzo Tipo, Andrea Apicella, Anna Grandone, Mario Diplomatico, Cesare Polito, Emanuele Miraglia Del Giudice, Angela La Manna, Laura Perrone
Frequently, general pediatricians could face a patient with syncope, which represents approximately 1% to 3% of emergency visits. Micturition syncope is a transient loss of consciousness with onset immediately before, during, or after micturition. Literature evidence indicates that healthy young men are a population with major risk for presenting micturition syncope, with a peak of incidence around 40 to 50 years of age. Usually, this syncope occurs in the morning, after wake-up, or, more generally, when the male patients assume the orthostatic position after a period of supine position in a warm bed...
November 14, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29135810/can-urodynamic-parameters-predict-sling-revision-for-voiding-dysfunction-in-women-undergoing-synthetic-midurethral-sling-placement
#11
Brian J Linder, Emanuel C Trabuco, John B Gebhart, Christopher J Klingele, John A Occhino, Daniel S Elliott, Deborah J Lightner
OBJECTIVE: The objective of the study was to evaluate the utility of urodynamic studies performed before primary midurethral sling placement for stress urinary incontinence in predicting the need for subsequent sling release for voiding dysfunction. METHODS: The health records of women managed with primary synthetic midurethral sling placement at Mayo Clinic (Rochester, MN) from January 1, 2002, to December 31, 2012, were reviewed. The primary outcome was surgical sling release for postoperative voiding dysfunction (ie, prolonged retention, elevated postvoid residual volumes with new voiding symptoms, or de novo onset or worsening of overactive bladder symptoms)...
November 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29135409/double-inlay-plus-ventral-onlay-buccal-mucosa-graft-for-simultaneous-penile-and-bulbar-urethral-stricture
#12
Luciano A Favorito, Paulo P Conte, Ulisses G Sobrinho, Rodrigo G Martins, Tomas Accioly
OBJECTIVES: Buccal mucosa grafts and fascio-cutaneous flaps are frequently used in long anterior urethral strictures (1). The inlay and onlay buccal mucosa grafts are easier to perform, do not need urethral mobilization and generally have good long-term results (2-4). In the present video, we present a case where we used a double buccal mucosa graft technique in a simultaneous penile and bulbar urethral stricture. MATERIALS AND METHODS: A 54 year-old male patient was submitted to appendectomy where a urethral catheter was used for two days in May 2015...
November 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29135141/-effectiveness-of-omnic-and-omnic-ocas-in-patients-with-lower-urinary-tract-symptoms-secondary-to-benign-prostatic-hyperplasia-multi-center-observing-program
#13
B U Shalekenov, Y A Kuandykov, S B Shalekenov
AIM: To investigate the effectiveness and safety of six-month treatment course of Omnic and Omnic Ocas in patients with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) in a routine urology practice in Kazakhstan. DESIGN: This was a multicenter prospective observational program involving the collection of data from patients with LUTS caused by BPH, who received Omnic Ocas or Omnic as the first line treatment. MATERIALS AND METHODS: The program comprised 1513 patients with a verified diagnosis of LUTS/BPH, who received Omnic Ocas or Omnic (tamsulosin) administered by urologists at hospitals in the Republic of Kazakhstan...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29134652/an-overview-of-polyamine-metabolism-in-pancreatic-ductal-adenocarcinoma
#14
REVIEW
Otto Phanstiel
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest major cancers, with a five year survival rate of less than 8%. With current therapies only giving rise to modest life extension, new approaches are desperately needed. Even though targeting polyamine metabolism is a proven anticancer strategy, there are no reports which thoroughly survey the literature describing the role of polyamine biosynthesis and transport in PDAC. This review seeks to fill this void by describing what is currently known about polyamine metabolism in PDAC and identifies new targets and opportunities to treat this disease...
November 14, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29134126/the-urinary-and-serum-levels-of-il-32-in-children-with-febrile-urinary-tract-infections
#15
Alireza Rafiei, Hamid Mohammadjafari, Ayat Ahifar, Abbas Alipour, Araz Mohammad Mirabi
Aim: We assessed the urinary and serum levels of IL-32 in pediatric patients with acute pyelonephritis (APN) with and without renal scarring. Results: We enrolled children aged 2 months to 16 years with APN. Dimercaptosuccinic acid scans and ultrasonography studies were ordered for all patients, and a voiding. A total of 86 children (aged 57 ± 39 months, 74 [86%] female) were enrolled in this study. Group 1 was composed of 19 (16 female) patients, group 2 of 38 (35 female) patients and group 3 of 29 (23 female) patients...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29133940/stimulators-and-activators-of-soluble-guanylate-cyclase-for-urogenital-disorders
#16
REVIEW
Fabiola Z Mónica, Edson Antunes
Lower urinary tract symptoms (LUTS), comprising storage (such as urinary incontinence and urinary frequency), voiding, and postmicturition symptoms, are highly prevalent conditions that affect millions of people worldwide. LUTS have a profound effect on quality of life and are a considerable cost to health care systems. In men specifically, BPH commonly leads to LUTS. Clinical studies also show an association of LUTS with erectile dysfunction (ED). Nitric oxide (NO) has long been recognized as an important nonadrenergic, noncholinergic (NANC) transmitter in bladder, urethra, prostate, and corpus cavernosum smooth muscle...
November 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29133002/clinical-characteristics-of-lumbosacral-spinal-dural-arteriovenous-fistula-davf-comparison-to-thoracic-davf
#17
Toshiki Endo, Takumi Kajitani, Tomoo Inoue, Kenichi Sato, Kuniyasu Niizuma, Hidenori Endo, Yasushi Matsumoto, Teiji Tominaga
OBJECTIVE: Spinal dural arteriovenous fistula (DAVF) occurs at any spinal level but the clinical characteristics of lumbosacral DAVF have not been well documented. Purpose of this study was to evaluate clinical characteristics of lumbosacral DAVF and compare these features to those in thoracic DAVF. METHODS: Twenty-five consecutive patients with 16 thoracic and 9 lumbosacral DAVF were included (mean age, 63.9 years; twenty men). All patients presented with progressive myelopathy...
November 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29132243/protective-effects-of-estradiol-and-dihydrotestosterone-following-spinal-cord-injury
#18
Dale R Sengelaub, Qi Han, Nai-Kui Liu, Melissa Maczuga, Violetta Szalavari, Stephanie Valencia, Xiao-Ming Xu
Spinal cord injury (SCI) results in lesions that destroy tissue and disrupt spinal tracts, producing deficits in locomotor and autonomic function. We previously demonstrated that motoneurons, and the muscles they innervate, show pronounced atrophy after SCI, and these changes are prevented by treatment with testosterone. Here we assessed if the testosterone active metabolites, estradiol and dihydrotestosterone, have similar protective effects after SCI. Young adult female rats received either sham or T9 spinal cord contusion injuries and were treated with estradiol, dihydrotestosterone, both, or nothing via Silastic capsules...
November 13, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29132118/primary-malignant-melanoma-of-the-female-urethra-report-of-a-rare-neoplasm-of-the-urinary-tract
#19
Namita Bhutani, Pradeep Kajal, Devendra Pawar
INTRODUCTION: Melanoma is a malignant tumor that can affect any area of the anatomical economy. Its occurance in the female urethra is extremely rare. We report a case of primary malignant urethral melanoma developed in an elderly female patient. PRESENTATION OF CASE: A 70 years old female presented with dysuria, poor stream, gross haematuria, intermittent blood spots, and a painful mass. On physical examination, there were no suspicious lesions on the skin. On external genital examination, a lesion at the level of the urethral meatus was observed...
November 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29132104/hollow-polydopamine-colloidal-composite-particles-structure-tuning-functionalization-and-applications
#20
Yanbing Wang, Bin Shang, Miao Liu, Feng Shi, Bo Peng, Ziwei Deng
Engineering hollow particles with high complexity in their morphology or composition is highly desirable for both fundamental studies and practical applications. Here, we combine mussel-inspired polydopamine (PDA) chemistry with template-assisted and hydrothermal approaches to explore a general approach for engineering hollow PDA colloidal composite particles with tunable complexities in terms of particle geometry, shell architecture and chemical composition. PDA coating and hydrothermal treatment are carried out sequentially in the same environment, which not only simplifies the experimental procedure but also avoids the use of hazardous core-removers...
October 27, 2017: Journal of Colloid and Interface Science
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