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https://www.readbyqxmd.com/read/29237698/oxys-small-rna-induces-cell-cycle-arrest-to-allow-dna-damage-repair
#1
Shir Barshishat, Maya Elgrably-Weiss, Jonathan Edelstein, Jens Georg, Sutharsan Govindarajan, Meytal Haviv, Patrick R Wright, Wolfgang R Hess, Shoshy Altuvia
To maintain genome integrity, organisms employ DNA damage response, the underlying principles of which are conserved from bacteria to humans. The bacterial small RNA OxyS of Escherichia coli is induced upon oxidative stress and has been implicated in protecting cells from DNA damage; however, the mechanism by which OxyS confers genome stability remained unknown. Here, we revealed an OxyS-induced molecular checkpoint relay, leading to temporary cell cycle arrest to allow damage repair. By repressing the expression of the essential transcription termination factor nusG, OxyS enables read-through transcription into a cryptic prophage encoding kilR The KilR protein interferes with the function of the major cell division protein FtsZ, thus imposing growth arrest...
December 13, 2017: EMBO Journal
https://www.readbyqxmd.com/read/29229829/psma-targeted-polyinosine-polycytosine-vector-induces-prostate-tumor-regression-and-invokes-an-antitumor-immune-response-in-mice
#2
Yael Langut, Alaa Talhami, Samarasimhareddy Mamidi, Alexei Shir, Maya Zigler, Salim Joubran, Anna Sagalov, Efrat Flashner-Abramson, Nufar Edinger, Shoshana Klein, Alexander Levitzki
There is an urgent need for an effective treatment for metastatic prostate cancer (PC). Prostate tumors invariably overexpress prostate surface membrane antigen (PSMA). We designed a nonviral vector, PEI-PEG-DUPA (PPD), comprising polyethylenimine-polyethyleneglycol (PEI-PEG) tethered to the PSMA ligand, 2-[3-(1, 3-dicarboxy propyl)ureido] pentanedioic acid (DUPA), to treat PC. The purpose of PEI is to bind polyinosinic/polycytosinic acid (polyIC) and allow endosomal release, while DUPA targets PC cells. PolyIC activates multiple pathways that lead to tumor cell death and to the activation of bystander effects that harness the immune system against the tumor, attacking nontargeted neighboring tumor cells and reducing the probability of acquired resistance and disease recurrence...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29166315/poly-implants-prosth%C3%A3-se-breast-implants-a-case-series-and-review-of-the-literature
#3
Doron Klein, Eran Hadad, Itay Wiser, Omer Wolf, Ortal Itzhaki Shapira, Shir Fucks, Lior Heller
BACKGROUND: Silicone breast implants from the French manufacturer Poly Implants Prosthèse (PIP) were recalled from the European market after the French regulator has revealed the implants contain non-medical-grade silicone filler. In December 2011, following a large increase in reported rupture rate and a possible cancer risk, the French Ministry of Health recommended consideration of the PIP explantation, regardless of their condition. In 2012, the Israel Ministry of Health recommended to replace the implants only upon suspected implant rupture...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29156148/cm-101-type-i-collagen-targeted-mr-imaging-probe-for-detection-of-liver-fibrosis
#4
Christian T Farrar, Eric M Gale, Richard Kennan, Ian Ramsay, Ricard Masia, Gunisha Arora, Kailyn Looby, Lan Wei, Jayashree Kalpathy-Cramer, Michelle M Bunzel, Chunlian Zhang, Yonghua Zhu, Taro E Akiyama, Michael Klimas, Shirly Pinto, Himashinie Diyabalanage, Kenneth K Tanabe, Valerie Humblet, Bryan C Fuchs, Peter Caravan
Purpose To evaluate the biodistribution, metabolism, and pharmacokinetics of a new type I collagen-targeted magnetic resonance (MR) probe, CM-101, and to assess its ability to help quantify liver fibrosis in animal models. Materials and Methods Biodistribution, pharmacokinetics, and stability of CM-101 in rats were measured with mass spectrometry. Bile duct-ligated (BDL) and sham-treated rats were imaged 19 days after the procedure by using a 1.5-T clinical MR imaging unit. Mice were treated with carbon tetrachloride (CCl4) or with vehicle two times a week for 10 weeks and were imaged with a 7...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29149330/s101-an-inhibitor-of-proliferating-t-cells-rescues-mice-from-superantigen-induced-shock
#5
Alexei Shir, Shoshana Klein, Idit Sagiv-Barfi, Tamar Geiger, Maya Zigler, Yael Langut, Nufar Edinger, Alexander Levitzki
Superantigens (SAg) are extremely potent bacterial toxins, which evoke a virulent immune response, inducing non-specific T-cell proliferation, rapid cytokine release and lethal toxic shock, for which there is no effective treatment. We previously developed a small molecule, S101, which potently inhibits proliferating T-cells (Sagiv-Barfi et al, Bioorg Med Chem (2010) 18:6404-6413). In a severe mouse model of toxic shock, a single injection of S101 given together with superantigen challenge, rescued 100% of the mice...
November 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29109176/candidalysin-drives-epithelial-signaling-neutrophil-recruitment-and-immunopathology-at-the-vaginal-mucosa
#6
Jonathan P Richardson, Hubertine M E Willems, David L Moyes, Saeed Shoaie, Katherine S Barker, Shir Lynn Tan, Glen E Palmer, Bernhard Hube, Julian R Naglik, Brian M Peters
Unlike other forms of candidiasis, vulvovaginal candidiasis, caused primarily by the fungal pathogen Candida albicans, is a disease of immunocompetent and otherwise healthy women. Despite its prevalence, the fungal factors responsible for initiating symptomatic infection remain poorly understood. One of the hallmarks of vaginal candidiasis is the robust recruitment of neutrophils to the site of infection, which seemingly do not clear the fungus, but rather exacerbate disease symptomatology. Candidalysin, a newly discovered peptide toxin secreted by C...
November 6, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29108830/vitamin-d-and-systemic-lupus-erythematosus-the-hype-and-the-hope
#7
REVIEW
Yehuda Shoenfeld, Roberto Giacomelli, Shir Azrielant, Onorina Berardicurti, John A Reynolds, Ian N Bruce
Over the past 20years, much has been written about the potential role of vitamin D in on adverse health outcomes. In recent years, evidence has accumulated regarding the effect of vitamin D on the immune system, and its different cells. Some studies have noted lower vitamin D concentrations in patients with SLE. These epidemiological data still not answer the question: is vitamin D deficiency the cause or the effect? To answer this, we will discuss the association between vitamin D deficiency and SLE and review the evidence from interventional studies...
November 3, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29104257/direct-feeding-at-the-breast-is-associated-with-breast-milk-feeding-duration-among-preterm-infants
#8
Shiran Pinchevski-Kadir, Shir Shust-Barequet, Michal Zajicek, Mira Leibovich, Tzipi Strauss, Leah Leibovitch, Iris Morag
BACKGROUND: In spite of high rates of initiating breast milk feeding (BMF) among preterm infants, a significant rate of discontinuation occurs shortly after discharge. AIM: To investigate the effect of mode (direct feeding at the breast vs. expressing) and exclusivity (breast milk combined with formula vs. breast milk only) as well as maternal perceptions on the duration of BMF among preterm infants. METHODS: The study included mothers whose infants were born before 32 weeks gestation, between January 2012 and August 2015 at Sheba Medical Center (SMC)...
November 1, 2017: Nutrients
https://www.readbyqxmd.com/read/29074498/ferritin-is-secreted-via-two-distinct-non-classical-vesicular-pathways
#9
Marianna Truman-Rosentsvit, Dina Berenbaum, Lior Spektor, Lyora A Cohen, Shirly Belizowsky-Moshe, Lena Lifshitz, Jing Ma, Wei Li, Ellina Kesselman, Inbal Abutbul-Ionita, Dganit Danino, Lucia Gutierrez, Huihui Li, Kuanyu Li, Huifang Lou, Maria Regoni, Maura Poli, Fabian Glaser, Tracey A Rouault, Esther G Meyron-Holtz
Ferritin turnover plays a major role in tissue iron homeostasis and ferritin misfunction is associated with impaired iron homeostasis and neurodegenerative diseases. In most eukaryotes, ferritin is considered an intracellular protein that stores iron in a non-toxic and bio-available form. In insects, ferritin is a classically secreted protein and plays a major role in systemic iron distribution. Mammalian ferritin lacks the signal peptide for classical ER-Golgi secretion but is found in serum and is secreted via a non-classical lysosomal secretion pathway...
October 26, 2017: Blood
https://www.readbyqxmd.com/read/29071332/effect-of-chewing-vs-swallowing-ticagrelor-on-platelet-inhibition-in-patients-with-st-segment-elevation-myocardial-infarction-a-randomized-clinical-trial
#10
Elad Asher, Shir Tal, Israel Mazin, Arsalan Abu-Much, Avi Sabbag, Moshe Katz, Ehud Regev, Fernando Chernomordik, Victor Guetta, Amit Segev, Dan Elian, Israel Barbash, Paul Fefer, Michael Narodistky, Roy Beigel, Shlomi Matetzky
Importance: Dual anti-platelet therapy represents standard care for treating patients with ST-segment elevation myocardial infarction (STEMI). Ticagrelor is a direct-acting P2Y12 inhibitor and, unlike clopidogrel and prasugrel, does not require metabolic activation. Objective: To evaluate whether chewing a loading dose (LD) of ticagrelor, 180 mg, vs traditional oral administration of an equal dose enhances platelet inhibition at 30 minutes and 1 hour after LD administration in patients with STEMI...
October 25, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29047716/dynamical-range-and-stability-enhancement-in-electrically-fused-microknot-optical-resonators
#11
Alexandra Logvinova, Gal Gottlieb, Shir Shahal, Moti Fridman, Yoav Linzon
Microknot resonators (MKRs), locally fused using a two-probe technique, have exhibited significantly improved optical performance and mechanical stability. They have been operated with low losses both in situ and as transferred devices. We found consistently more than threefold dynamical range enhancement, which remained stable in time, in electrically fused MKRs. These devices can be harbored in next-generation optical sensors, actuators, and optomechanical applications incorporating MKR-assisted microstructures taking advantage of this simple and robust fusing technique...
July 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29043816/axial-confocal-tomography-of-capillary-contained-colloidal-structures
#12
Shir R Liber, Ganit Indech, Ernest B van der Wee, Alexander V Butenko, Thomas E Kodger, Peter J Lu, Andrew B Schofield, David A Weitz, Alfons van Blaaderen, Eli Sloutskin
Confocal microscopy is widely used for three-dimensional (3D) sample reconstructions. Arguably, the most significant challenge in such reconstructions is posed by the resolution along the optical axis being significantly lower than in the lateral directions. In addition, the imaging rate is lower along the optical axis in most confocal architectures, prohibiting reliable 3D reconstruction of dynamic samples. Here, we demonstrate a very simple, cheap, and generic method of multiangle microscopy, allowing high-resolution high-rate confocal slice collection to be carried out with capillary-contained colloidal samples in a wide range of slice orientations...
October 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29039408/the-presentation-of-personalized-medical-information-and-its-impact-on-health-related-choices
#13
Shirly Bar-Lev, Dizza Beimel
No abstract text is available yet for this article.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29038547/a-novel-fer-fert-targeting-compound-selectively-evokes-metabolic-stress-and-necrotic-death-in-malignant-cells
#14
Yoav Elkis, Moshe Cohen, Etai Yaffe, Shirly Satmary-Tusk, Tal Feldman, Elad Hikri, Abraham Nyska, Ariel Feiglin, Yanay Ofran, Sally Shpungin, Uri Nir
Disruption of the reprogrammed energy management system of malignant cells is a prioritized goal of targeted cancer therapy. Two regulators of this system are the Fer kinase, and its cancer cell specific variant, FerT, both residing in subcellular compartments including the mitochondrial electron transport chain. Here, we show that a newly developed inhibitor of Fer and FerT, E260, selectively evokes metabolic stress in cancer cells by imposing mitochondrial dysfunction and deformation, and onset of energy-consuming autophagy which decreases the cellular ATP level...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29037903/novelties-in-the-field-of-autoimmunity-1st-saint-petersburg-congress-of-autoimmunity-the-bridge-between-east-and-west
#15
REVIEW
Shani Dahan, Yahel Segal, Abdulla Watad, Shir Azrielant, Asaf Shemer, Dror Maymon, Yuri I Stroev, Polina A Sobolevskaya, Elena A Korneva, Miri Blank, Boris Gilburd, Ora Shovman, Howard Amital, Michael Ehrenfeld, Amir Tanay, Shay Kivity, Elon Pras, Joav Chapman, Jan Damoiseaux, Ricard Cervera, Chaim Putterman, Iziaslav Shapiro, Luc Mouthon, Roberto Periconne, Nicola Bizzaro, Omry Koren, Gabriela Riemekasten, Valeriy A Chereshnev, Vadim I Mazurov, Mark Goloviznin, Victor Gurevich, Leonid P Churilov, Yehuda Shoenfeld
No abstract text is available yet for this article.
October 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29036853/smooth-leader-or-sharp-follower-playing-the-mirror-game-with-a-robot
#16
Shir Kashi, Shelly Levy-Tzedek
BACKGROUND: The increasing number of opportunities for human-robot interactions in various settings, from industry through home use to rehabilitation, creates a need to understand how to best personalize human-robot interactions to fit both the user and the task at hand. In the current experiment, we explored a human-robot collaborative task of joint movement, in the context of an interactive game. OBJECTIVE: We set out to test people's preferences when interacting with a robotic arm, playing a leader-follower imitation game (the mirror game)...
October 9, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28973513/non-random-length-distribution-of-individual-telomeres-in-immunodeficiency-centromeric-instability-and-facial-anomalies-syndrome-type-i
#17
Shira Sagie, Omer Edni, Joseph Weinberg, Shir Toubiana, Tal Kozlovski, Tzviel Frostig, Nirit Katzin, Irit Bar-Am, Sara Selig
Mutations in the de novo DNA methyltransferase DNMT3B lead to Immunodeficiency, Centromeric Instability and Facial anomalies (ICF) syndrome, type I. This syndrome is characterized, among other hypomethylated genomic loci, by severe subtelomeric hypomethylation that is associated with abnormally short telomere length. While it was demonstrated that the mean telomere length is significantly shorter in ICF type I cells, it is unknown whether all telomeres are equally vulnerable to shortening. To study this question we determined by combined telomere-FISH and spectral karyotyping the relative length of each individual telomere in lymphoblastoid cell lines (LCLs) generated from multiple ICF syndrome patients and control individuals...
November 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28972281/quantifying-guest-exchange-in-supramolecular-systems
#18
Liat Avram, Anthony D Wishard, Bruce C Gibb, Amnon Bar-Shir
The ability to accurately determine and quantitatively evaluate kinetic phenomena associated with supramolecular assemblies, in real time, is key to a better understanding of their defined architectures and diverse functionalities. Therefore, analytical tools that can precisely assess a wide range of exchange rates within such systems are of considerable importance. This study demonstrates the ability to use an NMR approach based on saturation transfer for the determination of rates of guest exchange from molecular capsules...
October 3, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28971604/an-integrin-antagonist-mk-0429-decreases-proteinuria-and-renal-fibrosis-in-the-zsf1-rat-diabetic-nephropathy-model
#19
Xiaoyan Zhou, Ji Zhang, Robin Haimbach, Wei Zhu, Rosemary Mayer-Ezell, Margarita Garcia-Calvo, Elizabeth Smith, Olga Price, Yanqing Kan, Emanuel Zycband, Yonghua Zhu, Maarten Hoek, Jason M Cox, Lijun Ma, David E Kelley, Shirly Pinto
Multiple integrins have been implicated in modulating renal function. Modulation of integrin function can lead to pathophysiological processes associated with diabetic nephropathy such as alterations in the glomerular filtration barrier and kidney fibrosis. The complexity of these pathophysiological changes implies that multiple integrin subtypes might need to be targeted to ameliorate the progression of renal disease. To address this hypothesis, we investigated the effects of MK-0429, a compound that was originally developed as an αvβ3 inhibitor for the treatment of osteoporosis, on renal function and fibrosis...
October 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28964501/enrichment-isolation-and-biodegradation-potential-of-long-branched-chain-alkylphenol-degrading-non-ligninolytic-fungi-from-wastewater
#20
Ranjith Kumar Rajendran, Chu-Ching Lin, Shir-Ly Huang, Roland Kirschner
4-t-Octylphenol (4-t-OP) has become a serious environmental concern due to the endocrine disruption in animals and humans. The biodegradation of 4-t-OP by pure cultures has been extensively investigated only in bacteria and wood-decaying fungi. In this study we isolated and identified 14 filamentous fungal strains from wastewater samples in Taiwan using 4-t-OP as a sole carbon and energy source. The isolates were identified based on sequences from different DNA regions. Of 14 fungal isolates, 10 strains grew effectively on solid medium with a wide variety of endocrine disrupting chemicals as the sole carbon and energy source...
September 27, 2017: Marine Pollution Bulletin
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