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https://www.readbyqxmd.com/read/28096334/role-of-cct-chaperonin-in-the-disassembly-of-mitotic-checkpoint-complexes
#1
Sharon Kaisari, Danielle Sitry-Shevah, Shirly Miniowitz-Shemtov, Adar Teichner, Avram Hershko
The mitotic checkpoint system prevents premature separation of sister chromatids in mitosis and thus ensures the fidelity of chromosome segregation. When this checkpoint is active, a mitotic checkpoint complex (MCC), composed of the checkpoint proteins Mad2, BubR1, Bub3, and Cdc20, is assembled. MCC inhibits the ubiquitin ligase anaphase promoting complex/cyclosome (APC/C), whose action is necessary for anaphase initiation. When the checkpoint signal is turned off, MCC is disassembled, a process required for exit from checkpoint-arrested state...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28091805/correlation-between-systemic-lupus-erythematosus-and-malignancies-a-cross-sectional-population-based-study
#2
Shir Azrielant, Shmuel Tiosano, Abdulla Watad, Naim Mahroum, Aaron Whitby, Doron Comaneshter, Arnon D Cohen, Howard Amital
Autoimmune conditions reflect dysregulation of the immune system; this may be of clinical significance in the development of several malignancies. Previous studies show an association between systemic lupus erythematosus (SLE) and the development of malignancies; however, their investigations into the development of specific malignancies are inconsistent, and their external validity may be questionable. The main objective of this study is to investigate the association between the presence of SLE and various malignancies, in a large-scale population-based study...
January 14, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28080315/we-know-who-likes-us-but-not-who-competes-against-us
#3
Noah Eisenkraft, Hillary Anger Elfenbein, Shirli Kopelman
Research on dyadic meta-accuracy suggests that people can accurately judge how their acquaintances feel toward them. However, existing studies have focused exclusively on positive feelings, such as liking. We present the first research on dyadic meta-accuracy for competition, a common dynamic among work colleagues. Data from the sales staff at a car dealership and students working on project teams suggest that the prevailing model of dyadic meta-accuracy breaks down for judgments of competition. For liking, projecting one's own feelings promotes dyadic meta-accuracy because colleagues tend to reciprocate each other's liking...
January 1, 2017: Psychological Science
https://www.readbyqxmd.com/read/28063725/despite-awareness-of-recommendations-why-do-health-care-workers-not-immunize-pregnant-women
#4
Anat Gesser-Edelsburg, Yaffa Shir-Raz, Samah Hayek, Sharon Aassaraf, Lior Lowenstein
Studies indicate uncertainty surrounding vaccination safety and efficacy for pregnant women, causing a central problem for health authorities. In this study, approximately 26% of participants do not recommend the tetanus, diphtheria, and acellular pertussis and influenza vaccines to their patients, although being aware of the health ministry recommendations. We found significant statistical discrepancies between the knowledge about the recommendations and their actual implementation, revealing the concerns of health care workers regarding vaccine safety...
January 4, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28060352/a-simple-way-to-measure-alterations-in-reward-seeking-behavior-using-drosophila-melanogaster
#5
Shir Zer, Julia Ryvkin, Harel J Wilner, Hila Zak, Anat Shmueli, Galit Shohat-Ophir
We describe a protocol for measuring ethanol self-administration in fruit flies (Drosophila melanogaster) as a proxy for changes in reward states. We demonstrate a simple way to tap into the fly reward system, modify experiences related to natural reward, and use voluntary ethanol consumption as a measure for changes in reward states. The approach serves as a relevant tool to study the neurons and genes that play a role in experience-mediated changes of internal state. The protocol is composed of two discrete parts: exposing the flies to rewarding and nonrewarding experiences, and assaying voluntary ethanol consumption as a measure of the motivation to obtain a drug reward...
December 15, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28059370/polarization-dependence-of-asymmetric-off-resonance-long-period-fiber-gratings
#6
Gilad Masri, Shir Shahal, Avi Klein, Hamootal Duadi, Moti Fridman
We present the polarization dependence of strong asymmetric long period fiber gratings written on tapered fibers. We found that for off-resonance conditions the spectral response and the output mode strongly depend on the input state of polarization. We utilize this dependence to obtain a mode selective device and demonstrate radially polarized and azimuthally polarized fiber lasers based on these asymmetric long period fiber gratings.
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28032914/pleomorphic-mantle-cell-lymphoma-morphologically-mimicking-diffuse-large-b-cell-lymphoma-common-cyclin-d1-negativity-and-a-simple-immunohistochemical-algorithm-to-avoid-the-diagnostic-pitfall
#7
Wen-Yu Chuang, Hung Chang, Gwo-Jyh Chang, Tzu-Hao Wang, Yu-Sun Chang, Tong-Hong Wang, Chi-Ju Yeh, Shir-Hwa Ueng, Hui-Ping Chien, Chiu-Yueh Chang, Yung-Liang Wan, Chuen Hsueh
AIMS: To characterize the clinicopathologic and genetic features of pleomorphic mantle cell lymphoma (PMCL) which morphologically mimics diffuse large B-cell lymphoma (DLBCL). METHODS AND RESULTS: We systematically screened 500 B-cell lymphomas morphologically compatible with DLBCL using an immunohistochemical algorithm of three markers (CD5, cyclin D1 and SOX11). Ten cases of PMCL were identified for further study, and surprisingly four (40%) of them were cyclin D1-negative...
December 29, 2016: Histopathology
https://www.readbyqxmd.com/read/28031488/cd74-is-a-novel-transcription-regulator
#8
Naama Gil-Yarom, Lihi Radomir, Lital Sever, Matthias P Kramer, Hadas Lewinsky, Chamutal Bornstein, Ronnie Blecher-Gonen, Zohar Barnett-Itzhaki, Vita Mirkin, Gilgi Friedlander, Lev Shvidel, Yair Herishanu, Elias J Lolis, Shirly Becker-Herman, Ido Amit, Idit Shachar
CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor. Macrophage migration inhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic intracellular domain (CD74-ICD), which regulates cell survival. In the present study, we characterized the transcriptional activity of CD74-ICD in chronic lymphocytic B cells. We show that following CD74 activation, CD74-ICD interacts with the transcription factors RUNX (Runt related transcription factor) and NF-κB and binds to proximal and distal regulatory sites enriched for genes involved in apoptosis, immune response, and cell migration...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27987401/biodegradation-of-the-endocrine-disrupter-4-tert-octylphenol-by-the-yeast-strain-candida-rugopelliculosa-rrky5-via-phenolic-ring-hydroxylation-and-alkyl-chain-oxidation-pathways
#9
Ranjith Kumar Rajendran, Shir-Ly Huang, Chu-Ching Lin, Roland Kirschner
4-(1,1,3,3-tetramethylbutane)-phenol (4-tert-OP) is one of the most prevalent endocrine disrupting pollutants. Information about bioremediation of 4-tert-OP remains limited, and no study has been reported on the mechanism of 4-tert-OP degradation by yeasts. The yeast Candida rugopelliculosa RRKY5 was proved to be able to utilize 4-methylphenol, bisphenol A, 4-ethylphenol, 4-tert-butylphenol, 4-tert-OP, 4-tert-nonylphenol, isooctane, and phenol under aerobic conditions. The optimum conditions for 4-tert-OP degradation were 30°C, pH 5...
February 2017: Bioresource Technology
https://www.readbyqxmd.com/read/27987102/characteristics-of-mesenteric-lymphadenitis-in-comparison-with-those-of-acute-appendicitis-in-children
#10
Itai Gross, Yael Siedner-Weintraub, Shir Stibbe, David Rekhtman, Daniel Weiss, Natalia Simanovsky, Dan Arbell, Saar Hashavya
: Mesenteric lymphadenitis (ML) is considered as one of the most common alternative diagnosis in a child with suspected acute appendicitis (AA). In this retrospective study, patients diagnosed with ML (n = 99) were compared in terms of demographic, clinical, and laboratory findings to patients diagnosed with AA (n = 102). This comparison was applied for both lymph nodes smaller and larger than 10 mm. When compared to patients with AA, patients with ML had significantly longer duration of symptoms prior to emergency department (ED) presentation (2...
February 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27941786/transcriptional-programs-that-control-expression-of-the-autoimmune-regulator-gene-aire
#11
Yonatan Herzig, Shir Nevo, Chamutal Bornstein, Miriam R Brezis, Sharon Ben-Hur, Aya Shkedy, Michal Eisenberg-Bord, Ben Levi, Michael Delacher, Yael Goldfarb, Eyal David, Leehee Weinberger, Sergey Viukov, Shifra Ben-Dor, Matthieu Giraud, Jacob H Hanna, Achim Breiling, Frank Lyko, Ido Amit, Markus Feuerer, Jakub Abramson
Aire is a transcriptional regulator that induces promiscuous expression of thousands of genes encoding tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs). While the target genes of Aire are well characterized, the transcriptional programs that regulate its own expression have remained elusive. Here we comprehensively analyzed both cis-acting and trans-acting regulatory mechanisms and found that the Aire locus was insulated by the global chromatin organizer CTCF and was hypermethylated in cells and tissues that did not express Aire...
February 2017: Nature Immunology
https://www.readbyqxmd.com/read/27919369/informing-the-development-of-an-internet-based-chronic-pain-self-management-program
#12
Amédé Gogovor, Regina Visca, Claudine Auger, Lucie Bouvrette-Leblanc, Iphigenia Symeonidis, Lise Poissant, Mark A Ware, Yoram Shir, Natacha Viens, Sara Ahmed
BACKGROUND: Self-management can optimize health outcomes for individuals with chronic pain (CP), an increasing fiscal and social burden in Canada. However, self-management is rarely integrated into the regular care (team activities and medical treatment) patients receive. Health information technology offers an opportunity to provide regular monitoring and exchange of information between patient and care team. OBJECTIVE: To identify information needs and gaps in chronic pain management as well as technology features to inform the development of an Internet-based self-management program...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27918636/4d-printing-of-shape-memory-based-personalized-endoluminal-medical-devices
#13
Matt Zarek, Nicola Mansour, Shir Shapira, Daniel Cohn
The convergence of additive manufacturing and shape-morphing materials is promising for the advancement of personalized medical devices. The capability to transform 3D objects from one shape to another, right off the print bed, is known as 4D printing. Shape memory thermosets can be tailored to have a range of thermomechanical properties favorable to medical devices, but processing them is a challenge because they are insoluble and do not flow at any temperature. This study presents here a strategy to capitalize on a series of medical imaging modalities to construct a printable shape memory endoluminal device, exemplified by a tracheal stent...
December 5, 2016: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/27858895/awareness-of-primary-spontaneous-hemorrhagic-angiosarcoma-of-the-breast-associated-with-kasabach-merritt-syndrome-in-a-pregnant-woman-by-enhanced-magnetic-resonance-imaging-a-care-compliant-case-report
#14
Wei-Ming Lin, Yu-Hsiang Juan, Yu-Ching Lin, Shir-Hwa Ueng, Yung-Feng Lo, Yun-Chung Cheung
INTRODUCTION: Primary breast angiosarcoma with spontaneous intratumoral bleeding associating with Kasabach-Merritt Syndrome is rarely reported. CASE FINDINGS/PATIENT CONCERNS: We herein present such a case in a 30-year-old pregnant woman who was initially diagnosed to hemangioma at her early gestation. However, the sudden rapid tumor growth was aware of the attention and intended for receiving the breast enhanced magnetic resonance imaging. DIAGNOSES AND INTERVENTIONS: The dynamic MRI enhancement showed inhomogenous enhancement at the periphery of the lobulated tumor on both early and delayed scans, otherwise a large hematoma was revealed at the center...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27856072/the-behind-the-scenes-activity-of-parental-decision-making-discourse-regarding-childhood-vaccination
#15
Anat Gesser-Edelsburg, Nathan Walter, Yaffa Shir-Raz, Oshrat Sassoni Bar-Lev, Shira Rosenblat
BACKGROUND: Vaccine compliance has long been a cause for concern for health authorities throughout the world. However very little effort has been made to examine parental discourse during the decision-making process. METHODS: An online survey was conducted (N = 437) to examine predictors of parents' attitudes regarding childhood vaccination. RESULTS: Hesitant parents were 4 times more likely to conduct intrafamily discussion regarding vaccination compared with provaccination parents (Exp[B] = 4...
November 14, 2016: American Journal of Infection Control
https://www.readbyqxmd.com/read/27810925/cd72-negatively-regulates-b-lymphocyte-responses-to-the-lupus-related-endogenous-toll-like-receptor-7-ligand-sm-rnp
#16
Chizuru Akatsu, Kenro Shinagawa, Nobutaka Numoto, Zhihong Liu, Ayse Konuskan Ucar, Mohammad Aslam, Shirly Phoon, Takahiro Adachi, Koji Furukawa, Nobutoshi Ito, Takeshi Tsubata
Toll-like receptor 7 (TLR7) plays an essential role in development of systemic lupus erythematosus by co-stimulating B cells reactive to the endogenous TLR7 ligand Sm/ribonucleoprotein (RNP), a crucial lupus self-antigen. However, how the TLR7-mediated autoimmune response is regulated is not yet known. In this study, we demonstrate that CD72, an inhibitory B cell co-receptor known to prevent development of lupus, recognizes Sm/RNP at the extracellular C-type lectin-like domain (CTLD) and specifically inhibits B cell response to Sm/RNP...
November 14, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27810359/the-testis-specific-usp26-is-a-deubiquitinating-enzyme-of-the-ubiquitin-ligase-mdm2
#17
Shirly Lahav-Baratz, Yelena Kravtsova-Ivantsiv, Shay Golan, Aaron Ciechanover
Murine double minute-2 (Mdm2) is one of the E3-ligases of the androgen receptor besides being the major regulator of the p53 tumor suppressor. The testis-specific USP26 was demonstrated to regulate the androgen receptor. In the present study we examined possible association between the deubiquitinating enzyme - ubiquitin specific protease 26 (USP26), and the oncoprotein E3 ligase - (Mdm-2). We analyzed the half-life time of USP26 in HEK293 cells. In a cell-free system we asked whether USP26 can be ubiquitinated by HeLa extract...
January 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27803347/dr-fitzcharles-et-al-reply
#18
Mary-Ann Fitzcharles, Peter A Ste-Marie, Emmanouil Rampakakis, John S Sampalis, Yoram Shir
No abstract text is available yet for this article.
November 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27766560/dynamics-of-flair-volume-changes-in-glioblastoma-and-prediction-of-survival
#19
Rachel Grossman, Nir Shimony, Dror Shir, Tal Gonen, Razi Sitt, Tali Jonas Kimchi, Carmit Ben Harosh, Zvi Ram
BACKGROUND: The extent of tumor resection (EOTR) calculated by enhanced T1 changes in glioblastomas has been previously reported to predict survival. However, fluid-attenuated inversion recovery (FLAIR) volume may better represent tumor burden. In this study, we report the first assessment of the dynamics of FLAIR volume changes over time as a predictive variable for post-resection overall survival (OS). METHODS: Contemporary data from 103 consecutive patients with complete imaging and clinical data who underwent resection of newly diagnosed glioblastoma followed by the Stupp protocol between 2010 and 2013 were analyzed...
October 20, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27741281/high-ancient-genetic-diversity-of-human-lice-pediculus-humanus-from-israel-reveals-new-insights-into-the-origin-of-clade-b-lice
#20
Nadia Amanzougaghene, Kosta Y Mumcuoglu, Florence Fenollar, Shir Alfi, Gonca Yesilyurt, Didier Raoult, Oleg Mediannikov
The human head louse, Pediculus humanus capitis, is subdivided into several significantly divergent mitochondrial haplogroups, each with particular geographical distributions. Historically, they are among the oldest human parasites, representing an excellent marker for tracking older events in human evolutionary history. In this study, ancient DNA analysis using real-time polymerase chain reaction (qPCR), combined with conventional PCR, was applied to the remains of twenty-four ancient head lice and their eggs from the Roman period which were recovered from Israel...
2016: PloS One
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