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https://www.readbyqxmd.com/read/29896150/recovery-of-repressed-memories-in-fibromyalgia-patients-treated-with-hyperbaric-oxygen-case-series-presentation-and-suggested-bio-psycho-social-mechanism
#1
Shai Efrati, Amir Hadanny, Shir Daphna-Tekoah, Yair Bechor, Kobi Tiberg, Nimrod Pik, Gil Suzin, Rachel Lev-Wiesel
Fibromyalgia Syndrome (FMS) is a condition considered to represent a prototype of central sensitization syndrome, characterized by chronic widespread pain and along with symptoms of fatigue, non-restorative sleep and cognitive difficulties. FMS can be induced by trauma, infection or emotional stress with cumulative evidence that dissociation is relatively frequent in FMS patients. Two randomized controlled trials have shown that hyperbaric oxygen therapy (HBOT) can induce neuroplasticity and be effective in patients suffering from FMS...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29848125/hope-and-self-efficacy-are-associated-with-better-satisfaction-with-life-in-people-with-als
#2
Shir Galin, Irit Heruti, Noa Barak, Marc Gotkine
The psychological phenotype in amyotrophic lateral sclerosis (ALS) is less negative than in other neurodegenerative diseases, manifested by a lower prevalence of psychopathology, such as anxiety and major depression, and a higher perceived quality of life by patients, irrespective of physical impairment. We hypothesized that positive psychological factors such as hope, optimism, and self-efficacy in people with ALS (PALS) were key determinants of satisfaction with life (SWL), despite physical impairment, and were protective against psychopathology...
May 31, 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29802907/sesame-an-unrecognized-trigger-of-food-protein-induced-enterocolitis-syndrome
#3
Adi Ovadia, Amit Nahum, Diana Tasher, Shirli Abiri, Larisa Epov, Aharon Kessel, Ilan Dalal
No abstract text is available yet for this article.
May 23, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29761050/plasma-proteomic-analysis-of-systemic-lupus-erythematosus-patients-using-liquid-chromatography-tandem-mass-spectrometry-with-label-free-quantification
#4
Rashmi Madda, Shih-Chang Lin, Wei-Hsin Sun, Shir-Ly Huang
Context: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with unknown etiology. Objective: Human plasma is comprised of over 10 orders of magnitude concentration of proteins and tissue leakages. The changes in the abundance of these proteins have played an important role in various human diseases. Therefore, the research objective of this study is to identify the significantly altered expression levels of plasma proteins from SLE patients compared with healthy controls using proteomic analysis...
2018: PeerJ
https://www.readbyqxmd.com/read/29759914/symptom-cluster-of-emotional-distress-fatigue-and-cognitive-difficulties-among-young-and-older-breast-cancer-survivors-the-mediating-role-of-subjective-stress
#5
Inbar Levkovich, Miri Cohen, Shirly Alon, Iryna Kuchuk, Bella Nissenbaum, Ella Evron, Simon Pollack, Georgeta Fried
OBJECTIVES: To examine the nature of the symptom cluster of emotional distress, fatigue, and cognitive difficulties in young and older breast cancer survivors (BCS); To assess the mediating role of subjective stress and coping strategies (emotional control and meaning-focused coping) in the association between age and symptom cluster. MATERIALS AND METHODS: Participants were 170 BCS, stages I-III, 1-12 months post-chemotherapy, filled-out the Fatigue, Emotional Control, Meaning-focused Coping, Emotional Distress and the Cognitive Difficulties Questionnaires...
May 11, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29749376/corylin-increases-the-sensitivity-of-hepatocellular-carcinoma-cells-to-chemotherapy-through-long-noncoding-rna-rad51-as1-mediated-inhibition-of-dna-repair
#6
Chin-Chuan Chen, Chi-Yuan Chen, Shir-Hwa Ueng, Chuen Hsueh, Chau-Ting Yeh, Jar-Yi Ho, Li-Fang Chou, Tong-Hong Wang
Corylin, a biologically active agent extracted from Psoralea corylifolia L. (Fabaceae), promotes bone differentiation and inhibits inflammation. Currently, few reports have addressed the biological functions that are regulated by corylin, and to date, no studies have investigated its antitumor activity. In this study, we used cell functional assays to analyze the antitumor activity of corylin in hepatocellular carcinoma (HCC). Furthermore, whole-transcriptome assays were performed to identify the downstream genes that were regulated by corylin, and gain-of-function and loss-of-function experiments were conducted to examine the regulatory roles of the above genes...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29746000/pericarditis-among-giant-cell-arteritis-patients-from-myth-to-reality
#7
Shmuel Tiosano, Yehuda Adler, Shir Azrielant, Yarden Yavne, Omer Gendelman, Dana Ben-Ami Shor, Doron Comaneshter, Guy Shalom, Arnon D Cohen, Howard Amital
BACKGROUND: Giant cell arteritis (GCA) is an inflammatory disease of unknown etiology affecting adults age > 50 years. GCA (also known as temporal arteritis) is a vasculitis of large and medium-size vessels that involves the extracranial branches of the carotid artery. Common manifestations include constitutional symptoms, headache, jaw claudication, scalp tenderness, and vision loss. Cardiac involvement in GCA is considered to be as low as 5%, and < 30 cases of pericarditis among GCA patients have been reported in the literature...
May 10, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29740329/mechanisms-underlying-the-risk-to-develop-drug-addiction-insights-from-studies-in-drosophila-melanogaster
#8
REVIEW
Julia Ryvkin, Assa Bentzur, Shir Zer-Krispil, Galit Shohat-Ophir
The ability to adapt to environmental changes is an essential feature of biological systems, achieved in animals by a coordinated crosstalk between neuronal and hormonal programs that allow rapid and integrated organismal responses. Reward systems play a key role in mediating this adaptation by reinforcing behaviors that enhance immediate survival, such as eating or drinking, or those that ensure long-term survival, such as sexual behavior or caring for offspring. Drugs of abuse co-opt neuronal and molecular pathways that mediate natural rewards, which under certain circumstances can lead to addiction...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29722856/long-term-clinical-outcomes-of-magnetically-navigated-rotor-ablation-as-an-adjunct-to-conventional-pulmonary-vein-isolation
#9
Gunjan Shukla, John Zimmerman, Zoya Shir, Roshan Shah, Edmund Hasanaj
Aims: The objective of this study is to evaluate the outcomes of magnetically guided ablation of atrial fibrillation (AF) rotors in conjunction with magnetically guided pulmonary vein isolation (PVI) in a large consecutive series of patients. Methods and results: A total of 110 consecutive patients with drug-refractory AF underwent rotor ablation followed by conventional PVI and ablation of other spontaneous arrhythmias, all of which were performed with remote magnetic navigation (RMN)...
May 1, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29706567/dgat2-inhibition-alters-aspects-of-triglyceride-metabolism-in-rodents-but-not-in-non-human-primates
#10
David G McLaren, Seongah Han, Beth Ann Murphy, Larissa Wilsie, Steven J Stout, Haihong Zhou, Thomas P Roddy, Judith N Gorski, Daniel E Metzger, Myung K Shin, Dermot F Reilly, Heather H Zhou, Marija Tadin-Strapps, Steven R Bartz, Anne-Marie Cumiskey, Thomas H Graham, Dong-Ming Shen, Karen O Akinsanya, Stephen F Previs, Jason E Imbriglio, Shirly Pinto
Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the final step in triglyceride (TG) synthesis and has been shown to play a role in regulating hepatic very-low-density lipoprotein (VLDL) production in rodents. To explore the potential of DGAT2 as a therapeutic target for the treatment of dyslipidemia, we tested the effects of small-molecule inhibitors and gene silencing both in vitro and in vivo. Consistent with prior reports, chronic inhibition of DGAT2 in a murine model of obesity led to correction of multiple lipid parameters...
June 5, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29701724/fused-microknot-optical-resonators-in-folded-photonic-tapers-for-in-liquid-durable-sensing
#11
Alexandra Logvinova, Shir Shahal, Moti Fridman, Yoav Linzon
Optical microknot fibers (OMFs) serve as localized devices, where photonic resonances (PRs) enable self-interfering elements sensitive to their environment. However, typical fragility and drifting of the knot severely limit the performance and durability of microknots as sensors in aqueous settings. Herein we present the fabrication, electrical fusing, preparation, and persistent detection of volatile liquids in multiple wetting⁻dewetting cycles of volatile compounds and quantify the persistent phase shifts with a simple model relating to the ambient liquid, enabling durable in-liquid sensing employing OMF PRs...
April 26, 2018: Sensors
https://www.readbyqxmd.com/read/29681474/ejaculation-induced-by-the-activation-of-crz-neurons-is-rewarding-to-drosophila-males
#12
Shir Zer-Krispil, Hila Zak, Lisha Shao, Shir Ben-Shaanan, Lea Tordjman, Assa Bentzur, Anat Shmueli, Galit Shohat-Ophir
The reward system is a collection of circuits that reinforce behaviors necessary for survival [1, 2]. Given the importance of reproduction for survival, actions that promote successful mating induce pleasurable feeling and are positively reinforced [3, 4]. This principle is conserved in Drosophila, where successful copulation is naturally rewarding to male flies, induces long-term appetitive memories [5], increases brain levels of neuropeptide F (NPF, the fly homolog of neuropeptide Y), and prevents ethanol, known otherwise as rewarding to flies [6, 7], from being rewarding [5]...
May 7, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29673988/sustainable-approach-in-phlorotannin-recovery-from-macroalgae
#13
Shir Reen Chia, Pau Loke Show, Siew-Moi Phang, Tau Chuan Ling, Hwai Chyuan Ong
In this present study, alcohol/salt liquid biphasic system was used to extract phlorotannin from brown macroalgae. Liquid biphasic system is a new green technology that integrated with various processes into one-step, by concentrating, separating and purifying the bioproduct in a unit operation. The solvent used is non-toxic and there is potential for solvent recovery which is beneficial to the environment. Phlorotannin is a bioactive compound that has gained much attention due to its health beneficial effect...
April 16, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29649222/detecting-hierarchical-levels-of-connectivity-in-a-population-of-acacia-tortilis-at-the-northern-edge-of-the-species-global-distribution-combining-classical-population-genetics-and-network-analyses
#14
Yael S Rodger, Gili Greenbaum, Micha Silver, Shirli Bar-David, Gidon Winters
Genetic diversity and structure of populations at the edge of the species' spatial distribution are important for potential adaptation to environmental changes and consequently, for the long-term survival of the species. Here, we combined classical population genetic methods with newly developed network analyses to gain complementary insights into the genetic structure and diversity of Acacia tortilis, a keystone desert tree, at the northern edge of its global distribution, where the population is under threat from climatic, ecological, and anthropogenic changes...
2018: PloS One
https://www.readbyqxmd.com/read/29577055/perianal-mucinous-adenocarcinoma-diagnosed-by-histological-study-of-anorectal-abscess-with-fistula
#15
Shir Li Jee, Hizami Amin-Tai, Nik Qisti Fathi, Mohd Faisal Jabar
Perianal mucinous adenocarcinoma (PMA) is an oncologic rarity that poses a diagnostic and therapeutic dilemma for treating clinicians because there are few reported cases and an absence of definitive guidelines. We report a patient who had been treated with local surgery for recurrent perianal abscess with fistula for 3 years. Biopsy of the indurated tissue overlying his surgical scars revealed PMA. Neoadjuvant concurrent chemoradiotherapy followed by abdominoperineal resection was planned to address the locally advanced disease and ongoing sepsis...
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29527860/recurrent-pericarditis-is-immunotherapy-the-answer
#16
EDITORIAL
Shir Azrielant, Yehuda Shoenfeld, Yehuda Adler
No abstract text is available yet for this article.
March 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29522808/behavioral-reconsolidation-interference-with-episodic-memory-within-subjects-is-elusive
#17
Daniel A Levy, Rotem Mika, Cecilia Radzyminski, Shir Ben-Zvi, Roni Tibon
In studies of behavioral reconsolidation interference, reactivation of a consolidated memory using some form of reminder is followed by the presentation of new information that can cause interference with that memory. Under these conditions, the interference not only impairs retrieval by indirect processes such as cue interference, but supposedly disrupts the original memory trace directly. Almost all studies of behavioral reconsolidation interference in episodic memory in humans have employed between-subjects paradigms, and deduced reminder effects from intrusion errors...
April 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29518272/calcium-fluoride-nanocrystals-tracers-for-in-vivo-19-f-magnetic-resonance-imaging
#18
Idan Ashur, Hyla Allouche-Arnon, Amnon Bar-Shir
Inorganic nanocrystals (NCs) have been extensively developed for a variety of uses. The ability to obtain high-resolution NMR signals from the core nuclei of NCs in solution could offer new opportunities in materials sciences and MR imaging. Herein, we demonstrate that small, water-soluble 19 F-ionic NCs can average out homonuclear dipolar interactions, enabling one to obtain high-resolution 19 F NMR signals in solution that reflect the MR properties of F- in the crystal core. Decorating 19 F-NC surfaces with a biocompatible poly(ethylene glycol) coating maintains colloidal stability in water while preserving the NC high-resolution 19 F NMR properties, even after further functionalization...
March 8, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29510994/tight-junction-protein-claudin-2-promotes-self-renewal-of-human-colorectal-cancer-stem-like-cells
#19
Sophie Paquet-Fifield, Shir Lin Koh, Lesley Cheng, Laura Marie Beyit, Carolyn E Shembrey, Christina Moelck, Corina Behrenbruch, Marina Papin, Meritxell Gironella, Sophie Guelfi, Ramona Nasr, Fanny Grillet, Michel Prudhomme, Jean-François Bourgaux, Antoni Castells, Jean-Marc Pascussi, Alexander G Heriot, Alain Puisieux, Melissa J Davis, Julie Pannequin, Andrew F Hill, Erica K Sloan, Frédéric Hollande
Post-treatment recurrence of colorectal cancer (CRC), the third most lethal cancer worldwide, is often driven by a subpopulation of cancer stem cells (CSCs). The tight junction (TJ) protein claudin-2 is overexpressed in human CRC where it enhances cell proliferation, colony formation, and chemoresistance in vitro. While several of these biological processes are features of the CSC phenotype, a role for claudin-2 in the regulation of these has not been identified. Here we report that elevated claudin-2 expression in stage II/III colorectal tumors is associated with poor recurrence-free survival following 5-FU-based chemotherapy, an outcome in which CSC play an instrumental role...
March 6, 2018: Cancer Research
https://www.readbyqxmd.com/read/29484537/establishment-of-two-basal-like-breast-cancer-cell-lines-with-extremely-low-tumorigenicity-from-taiwanese-premenopausal-women
#20
Wen-Ling Kuo, Shir-Hwa Ueng, Chun-Hsing Wu, Li-Yu Lee, Yun-Shien Lee, Ming-Chin Yu, Shin-Cheh Chen, Chi-Chang Yu, Chi-Neu Tsai
The research of carcinogenetic mechanisms of breast cancer in different ethnic backgrounds is an interesting field, as clinical features of breast cancers vary among races. High premenopausal incidence is distinctive in East-Asian breast cancer. However, human cell lines derived from Asian primary breast tumor are rare. To provide alternative cell line models with a relevant genetic background, we aimed to establish breast cancer cell lines from Taiwanese patients of Han-Chinese ethnicity. Fresh tissue from mammary tumors were digested into organoids, plated and grown in basal serum-free medium of human mammary epithelial cells (HuMEC) with supplements...
April 2018: Human Cell
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