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Rachel Grossman, Nir Shimony, Dror Shir, Tal Gonen, Razi Sitt, Tali Jonas Kimchi, Carmit Ben Harosh, Zvi Ram
BACKGROUND: The extent of tumor resection (EOTR) calculated by enhanced T1 changes in glioblastomas has been previously reported to predict survival. However, fluid-attenuated inversion recovery (FLAIR) volume may better represent tumor burden. In this study, we report the first assessment of the dynamics of FLAIR volume changes over time as a predictive variable for post-resection overall survival (OS). METHODS: Contemporary data from 103 consecutive patients with complete imaging and clinical data who underwent resection of newly diagnosed glioblastoma followed by the Stupp protocol between 2010 and 2013 were analyzed...
October 20, 2016: Annals of Surgical Oncology
Nadia Amanzougaghene, Kosta Y Mumcuoglu, Florence Fenollar, Shir Alfi, Gonca Yesilyurt, Didier Raoult, Oleg Mediannikov
The human head louse, Pediculus humanus capitis, is subdivided into several significantly divergent mitochondrial haplogroups, each with particular geographical distributions. Historically, they are among the oldest human parasites, representing an excellent marker for tracking older events in human evolutionary history. In this study, ancient DNA analysis using real-time polymerase chain reaction (qPCR), combined with conventional PCR, was applied to the remains of twenty-four ancient head lice and their eggs from the Roman period which were recovered from Israel...
2016: PloS One
Kristian K Jensen, Marija Tadin-Strapps, Sheng-Ping Wang, James Hubert, Yanqing Kan, Yong Ma, David G McLaren, Stephen F Previs, Kithsiri B Herath, Ablatt Mahsut, Andy Liaw, Shubing Wang, Steven J Stout, CarolAnn Keohan, Gail Forrest, David Coelho, Satya Yendluri, Stephanie Williams, Martin Koser, Steven Bartz, Karen O Akinsanya, Shirly Pinto
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription factors SREBP-1 and -2. SREBPs regulate the expression of genes involved in fatty acid and cholesterol biosynthesis, and LDL-C clearance through the regulation of LDLR and PCSK9 expression. To further test the potential of SCAP as a novel target for treatment of dyslipidemia, we used short interfering RNAs (siRNA) to inhibit hepatic SCAP expression and assess the effect on PCSK9, LDLR and lipids in mice and rhesus monkeys...
October 5, 2016: Journal of Lipid Research
Noa Eliakim-Raz, Roi Babaoff, Dafna Yahav, Shirly Yanai, Hila Shaked, Jihad Bishara
BACKGROUND: The clinical characteristics of internal medicine ward (IMW) patients with candidemia are unclear. The aim of this study was to define the clinical characteristics of candidemic IMW patients and to study the incidence, species distribution, and outcomes of these patients compared to surgical and intensive care unit (ICU) candidemic patients. METHODS: A retrospective cohort of candidemic patients in IMWs, general surgery wards, and an ICU at Beilinson Hospital during the period 2007-2014 was analyzed...
September 20, 2016: International Journal of Infectious Diseases: IJID
Shir Bergson, Inbal Itzhak, Talya Wasserman, Anastasia Gelgor, Inna Kalt, Ronit Sarid
Kaposi's sarcoma-associated herpesvirus (KSHV) is implicated in the etiology of several human malignancies. KSHV open reading frame (orf) 35 encodes a conserved gammaherpesvirus protein with an, as yet, unknown function. Employing the bacterial artificial chromosome (BAC) system, we generated a recombinant viral clone that fails to express ORF35 (BAC16-ORF35-stop) but preserves intact adjacent and overlapping reading frames. Using this construct, we studied the role of this previously uncharacterized gene product during lytic reactivation of KSHV...
September 15, 2016: Virology
G Fatima Shirly Anitha, Lakshmi Velmurugan, Shanthi Sangareddi, Krishnamurthy Nedunchelian, Vinoth Selvaraj
BACKGROUND AND AIMS: Noninvasive ventilation (NIV) is an emerging popular concept, which includes bi-level positive airway pressure or continuous positive airway pressure (CPAP). In settings with scarce resources for NIV machines, CPAP can be provided through various indigenous means and one such mode is flow inflating device - Jackson-Rees circuit (JR)/Bain circuit. The study analyses the epidemiology, various clinical indications, predictors of CPAP failure, and stresses the usefulness of flow inflating device as an indigenous way of providing CPAP...
August 2016: Indian Journal of Critical Care Medicine
Dana Chen, Yaron Orenstein, Rada Golodnitsky, Michal Pellach, Dorit Avrahami, Chaim Wachtel, Avital Ovadia-Shochat, Hila Shir-Shapira, Adi Kedmi, Tamar Juven-Gershon, Ron Shamir, Doron Gerber
Transcription factors (TFs) alter gene expression in response to changes in the environment through sequence-specific interactions with the DNA. These interactions are best portrayed as a landscape of TF binding affinities. Current methods to study sequence-specific binding preferences suffer from limited dynamic range, sequence bias, lack of specificity and limited throughput. We have developed a microfluidic-based device for SELEX Affinity Landscape MAPping (SELMAP) of TF binding, which allows high-throughput measurement of 16 proteins in parallel...
2016: Scientific Reports
Yun-Chung Cheung, Yu-Hsiang Juan, Yu-Ching Lin, Yung-Feng Lo, Hsiu-Pei Tsai, Shir-Hwa Ueng, Shin-Cheh Chen
BACKGROUND: Mammography screening is a cost-efficient modality with high sensitivity for detecting impalpable cancer with microcalcifications, and results in reduced mortality rates. However, the probability of finding microcalcifications without associated cancerous masses varies. We retrospectively evaluated the diagnosis and cancer probability of the non-mass screened microcalcifications by dual-energy contrast-enhanced spectral mammography (DE-CESM). PATIENTS AND METHODS: With ethical approval from our hospital, we enrolled the cases of DE-CESM for analysis under the following inclusion criteria: (1) referrals due to screened BI-RADS 4 microcalcifications; (2) having DE-CESM prior to stereotactic biopsy; (3) no associated mass found by sonography and physical examination; and (4) pathology-based diagnosis using stereotactic vacuum-assisted breast biopsy...
2016: PloS One
Abdulla Watad, Shmuel Tiosano, Shir Azrielant, Aaron Whitby, Doron Comaneshter, Arnon D Cohen, Yehuda Shoenfeld, Howard Amital
OBJECTIVES: Several reports have indicated an association between systemic lupus erythematosus (SLE) and low levels of vitamin D. We examined several blood work parameters in SLE patients and controls and performed an extensive data analysis in order to investigate the links between blood levels of calcium, vitamin D, and SLE disease. METHODS: 4,278 SLE patients and 16,443 age and sex-matched controls were selected from a national health insurer database in Israel...
August 31, 2016: Clinical and Experimental Rheumatology
Tuan Ngoc Nguyen, Chen-Wei Yeh, Po-Chun Tsai, Kyoung Lee, Shir-Ly Huang
Pseudomonas nitroreducens TX1 is of special interest because of its ability to utilize 0.05% to 20% octylphenol polyethoxylates (OPEOn) as sole carbon source. In this study, a library containing 30,000 Tn5-insertion mutants of the wild-type strain TX1 was constructed and screened for the OPEOn utilization and 93 mutants were found to be unable to grow on OPEOn In total 42 separate disrupted genes were identified and the proteins encoded by the genes were then classified into various categories, namely information storage and processing (14...
September 2, 2016: Applied and Environmental Microbiology
Rinat Gabbay-Benziv, E Albert Reece, Fang Wang, Amnon Bar-Shir, Chris Harman, Ozhan M Turan, Peixin Yang, Sifa Turan
BACKGROUND: The mouse embryo is ideal for studying human cardiac development. However, laboratory discoveries do not easily translate into clinical findings partially because of histological diagnostic techniques that induce artifacts and lack standardization. AIM: To present a step-wise approach using 17.6T MRI, for evaluation of mice embryonic heart and accurate identification of congenital heart defects. SUBJECTS: 17.5-embryonic days embryos from low-risk (non-diabetic) and high-risk (diabetic) model dams...
August 26, 2016: Magnetic Resonance Imaging
Daniel Shir, Zachary S Ballard, Aydogan Ozcan
Mechanical flexibility and the advent of scalable, low-cost, and high-throughput fabrication techniques have enabled numerous potential applications for plasmonic sensors. Sensitive and sophisticated biochemical measurements can now be performed through the use of flexible plasmonic sensors integrated into existing medical and industrial devices or sample collection units. More robust sensing schemes and practical techniques must be further investigated to fully realize the potentials of flexible plasmonics as a framework for designing low-cost, embedded and integrated sensors for medical, environmental, and industrial applications...
July 2016: IEEE Journal of Selected Topics in Quantum Electronics
Shir Li Jee, Razman Jarmin, Kin Foong Lim, Krishnan Raman
BACKGROUND: In patients with acute biliary pancreatitis (ABP), cholecystectomy is mandatory to prevent further biliary events, but the precise timing of cholecystectomy for mild to moderate disease remain a subject of ongoing debate. The aim of this study is to assess the outcomes of early versus delayed cholecystectomy. We hypothesize that early cholecystectomy as compared to delayed cholecystectomy reduces recurrent biliary events without a higher peri-operative complication rate. METHODS: Patients with mild to moderate ABP were prospectively randomized to either an early cholecystectomy versus a delayed cholecystectomy group...
August 13, 2016: Asian Journal of Surgery
Yair Amichai-Hamburger, Shir Etgar
This study investigated the relationship between smartphone multitasking and romantic intimacy. Participants currently in a romantic relationship (N = 128; 98 women; M age = 26.7 years, SD = 4.3) filled out two sets of questionnaires: The Emotional Intimacy Scale, measuring romantic intimacy, and the mobile phone interference in life scale, measuring multitasking on a smartphone. Participants filled out each questionnaire twice, once in relation to themselves and once in relation to their partner (for the partner questionnaire, statements were altered from the first person to the third person singular, he/she instead of I)...
August 5, 2016: Psychological Reports
Zohar Bloom-Ackermann, Nitai Steinberg, Gili Rosenberg, Yaara Oppenheimer-Shaanan, Dan Pollack, Shir Ely, Nimrod Storzi, Asaf Levy, Ilana Kolodkin-Gal
Toxin-antitoxin modules are gene pairs encoding a toxin and its antitoxin, and are found on the chromosomes of many bacteria, including pathogens. Here, we characterize the specific contribution of the TxpA and YqcG toxins in elimination of defective cells from developing Bacillus subtilis biofilms. Upon nutrient limitation, defective cells accumulated in the biofilm breaking its symmetry. Deletion of the toxins resulted in accumulation of morphologically abnormal cells, and interfered with the proper development of the multicellular community...
July 23, 2016: Environmental Microbiology
Shir Hofstetter, Naama Friedmann, Yaniv Assaf
Human brain imaging revealed that the brain can undergo structural plasticity following new learning experiences. Most magnetic resonance imaging (MRI) uncovered morphometric alternation in cortical density after the long-term training of weeks to months. A recent diffusion tensor imaging (DTI) study has found changes in diffusion indices after 2 h of training, primarily in the hippocampus. However, whether a short learning experience can induce microstructural changes in the neocortex is still unclear. Here, we used diffusion MRI, a method sensitive to tissue microstructure, to study cortical plasticity...
July 23, 2016: Brain Structure & Function
Jordi Perez, Sara Olivier, Emmanouil Rampakakis, Manuel Borod, Yoram Shir
Context. The McGill University Health Center (MUHC) Cancer Pain Clinic offers an interdisciplinary approach to cancer pain management for patients. The core team includes a nurse clinician specialist in oncology and palliative care, a palliativist, an anaesthetist, and a radiation oncologist. This tailored approach includes pharmacological and nonpharmacological therapies offered concurrently in an interdisciplinary fashion. Objectives. Description of the interdisciplinary MUHC cancer pain approach and analysis of treatments and outcomes...
2016: Pain Research & Management: the Journal of the Canadian Pain Society
Laor Orshan, Shirly Elbaz, Yossi Ben-Ari, Fouad Akad, Ohad Afik, Ira Ben-Avi, Debora Dias, Dan Ish-Shalom, Liora Studentsky, Irina Zonstein
BACKGROUND: Zoonotic cutaneous leishmaniasis has long been endemic in Israel. In recent years reported incidence of cutaneous leishmaniasis increased and endemic transmission is being observed in a growing number of communities in regions previously considered free of the disease. Here we report the results of an intensive sand fly study carried out in a new endemic focus of Leishmania major. The main objective was to establish a method and to generate a data set to determine the exposure risk, sand fly populations' dynamics and evaluate the efficacy of an attempt to create "cordon sanitaire" devoid of active jird burrows around the residential area...
July 2016: PLoS Neglected Tropical Diseases
Scott P Salowe, Lei Zhang, Hratch J Zokian, Jennifer J Gesell, Deborah L Zink, Judyann Wiltsie, Xi Ai, Michael Kavana, Shirly Pinto
PCSK9 plays a significant role in regulating low-density lipoprotein (LDL) cholesterol levels and has become an important drug target for treating hypercholesterolemia. Although a member of the serine protease family, PCSK9 only catalyzes a single reaction, the autocleavage of its prodomain. The maturation of the proprotein is an essential prerequisite for the secretion of PCSK9 to the extracellular space where it binds the LDL receptor and targets it for degradation. We have found that a construct of proPCSK9 where the C-terminal domain has been truncated has sufficient stability to be expressed and purified from Escherichia coli for the in vitro study of autoprocessing...
July 7, 2016: Journal of Biomolecular Screening
Shir Shahal, Avi Klein, Gilad Masri, Moti Fridman
We present fusing of a fiber micro-knot by a CO<sub>2</sub> laser beam. We demonstrate tuning of the coupling strength and tuning of the spectral resonance of the micro-knot by the fusing process. The experimental results reveal that fusing the fiber micro-knots increases the coupling efficiency and improves the robustness and the stability of the micro-knots.
June 10, 2016: Applied Optics
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