Shravan Leonard-Murali, Chetana Bhaskarla, Ghanshyam S Yadav, Sudeep K Maurya, Chenna R Galiveti, Joshua A Tobin, Rachel J Kann, Eishan Ashwat, Patrick S Murphy, Anish B Chakka, Vishal Soman, Paul G Cantalupo, Xinming Zhuo, Gopi Vyas, Dara L Kozak, Lindsey M Kelly, Ed Smith, Uma R Chandran, Yen-Michael S Hsu, Udai S Kammula
Immune checkpoint inhibition has shown success in treating metastatic cutaneous melanoma but has limited efficacy against metastatic uveal melanoma, a rare variant arising from the immune privileged eye. To better understand this resistance, we comprehensively profile 100 human uveal melanoma metastases using clinicogenomics, transcriptomics, and tumor infiltrating lymphocyte potency assessment. We find that over half of these metastases harbor tumor infiltrating lymphocytes with potent autologous tumor specificity, despite low mutational burden and resistance to prior immunotherapies...
April 16, 2024: Nature Communications