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Uveal melanoma

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https://www.readbyqxmd.com/read/29142760/outcomes-of-primary-endoresection-for-choroidal-melanoma
#1
Andre A C Vidoris, Andre Maia, Marcia Lowen, Melina Morales, Jordan Isenberg, Bruno F Fernandes, Rubens N Belfort
Purpose: To review long time treatment results in patients with small or medium sized choroidal melanoma who underwent surgical tumor endoresection as a primary treatment when plaque radiotherapy was unable and patients declined enucleation. Materials and methods: Patients were evaluated for best corrected visual acuity (BCVA), and underwent biomicroscopy, indirect ophthalmoscopy, retinography and ultrasound as well as the usual systemic workup. Study inclusion required the absence of scleral invasion or metastasis and an anterior margin not exceeding the pars plana or the ciliary body...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29141225/a-comprehensive-patient-derived-xenograft-collection-representing-the-heterogeneity-of-melanoma
#2
Clemens Krepler, Katrin Sproesser, Patricia Brafford, Marilda Beqiri, Bradley Garman, Min Xiao, Batool Shannan, Andrea Watters, Michela Perego, Gao Zhang, Adina Vultur, Xiangfan Yin, Qin Liu, Ioannis N Anastopoulos, Bradley Wubbenhorst, Melissa A Wilson, Wei Xu, Giorgos Karakousis, Michael Feldman, Xiaowei Xu, Ravi Amaravadi, Tara C Gangadhar, David E Elder, Lauren E Haydu, Jennifer A Wargo, Michael A Davies, Yiling Lu, Gordon B Mills, Dennie T Frederick, Michal Barzily-Rokni, Keith T Flaherty, Dave S Hoon, Michael Guarino, Joseph J Bennett, Randall W Ryan, Nicholas J Petrelli, Carol L Shields, Mizue Terai, Takami Sato, Andrew E Aplin, Alexander Roesch, David Darr, Steve Angus, Rakesh Kumar, Ensar Halilovic, Giordano Caponigro, Sebastien Jeay, Jens Wuerthner, Annette Walter, Matthias Ocker, Matthew B Boxer, Lynn Schuchter, Katherine L Nathanson, Meenhard Herlyn
Therapy of advanced melanoma is changing dramatically. Following mutational and biological subclassification of this heterogeneous cancer, several targeted and immune therapies were approved and increased survival significantly. To facilitate further advancements through pre-clinical in vivo modeling, we have established 459 patient-derived xenografts (PDX) and live tissue samples from 384 patients representing the full spectrum of clinical, therapeutic, mutational, and biological heterogeneity of melanoma...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29122287/radiologic-and-histopathologic-correlation-of-different-growth-patterns-of-metastatic-uveal-melanoma-to-the-liver
#3
Albert Liao, Pardeep Mittal, David H Lawson, Jenny J Yang, Eszter Szalai, Hans E Grossniklaus
PURPOSE: The purpose of this study was to correlate magnetic resonance imaging (MRI) radiographic results with histopathologic growth patterns of metastatic uveal melanoma (UM) to the liver. DESIGN: Clinicopathologic correlation. PARTICIPANTS: Patients with metastatic UM to the liver. METHODS: A retrospective review of MRI images of patients with metastatic UM to the liver at a single institution between 2004 and 2016 was performed...
November 6, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29121185/molecular-characteristics-of-conjunctival-melanoma-using-whole-exome-sequencing
#4
Swarup S Swaminathan, Matthew G Field, David Sant, Gaofeng Wang, Anat Galor, Sander R Dubovy, J William Harbour, Carol L Karp
Importance: Conjunctival melanoma (CM) is a highly aggressive ocular cancer for which treatment options are limited; the molecular pathogenesis is poorly understood. Objective: To identify the molecular characteristics of CM using next-generation whole-exome sequencing (WES). Design, Setting, and Participants: Whole-exome sequencing was performed on tumor DNA extracted from the archived specimens of 5 patients with CM who had been treated with surgical excision between 2006 and 2011...
November 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29116399/intravitreal-bevacizumab-for-neovascular-glaucoma-in-uveal-melanoma-treated-by-proton-beam-therapy
#5
Amir Mahdjoubi, Marie Najean, Stéphanie Lemaitre, Sylvain Dureau, Rémi Dendale, Christine Levy, Livia Lumbroso-Le Rouic, Laurence Desjardins, Nathalie Cassoux
BACKGROUND: To evaluate the efficacy of bevacizumab on reduction of the enucleation rate and control of intraocular pressure (IOP) in neovascular glaucoma (NVG)-complicating proton beam therapy for UM and to identify the determinants of the efficacy of bevacizumab. METHODS: Retrospective comparative study of patients with rubeosis following proton therapy for uveal melanoma. Patients were divided into two groups: a bevacizumab group and a control group which comprised two subgroups: panretinal photocoagulation (PRP)/cryotherapy and observation subgroups...
November 7, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29109715/specific-detection-of-serum-antibodies-against-bkpyv-a-small-dna-tumour-virus-in-patients-affected-by-choroidal-nevi
#6
Silvia Pietrobon, Ilaria Bononi, Francesca Lotito, Paolo Perri, Sara Violanti, Elisa Mazzoni, Fernanda Martini, Mauro G Tognon
Ocular or choroidal nevus (CN) is a rare benign neoplastic lesion of the eye. The cause of CN onset/progression, which arises from the transformation of ocular melanocytes, is not known. A fraction of CN patients may develop uveal melanoma. The objective of this study was to investigate the association between CN and BK polyomavirus (BKPyV), a small DNA tumor virus. Serum IgG antibodies which react with BKPyV antigens were analyzed. An indirect E.L.I.S.A. using synthetic peptides that mimic BKPyV antigens was employed...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29109346/-a-case-of-metastatic-uveal-melanoma-of-the-liver-and-digestive-tract
#7
Mami Hachiya, Kenichi Satoh, Shinichiro Takami, Shinichiro Uetake, Seiji Arihiro, Atsushi Hokari, Tomohisa Ishikawa, Ichiro Takagi, Hisao Tajiri, Masayuki Saruta
Metastasis of uveal melanoma of the digestive tract is rare. We report a case of a patient with metastatic uveal melanoma of the liver and digestive tract. A 68-year-old man was admitted with primary complaint of appetite loss and fatigue. Abdominal computed tomography revealed a 13-cm diameter tumor in the right lobe of the liver. We diagnosed him with metastatic uveal melanoma. We performed a liver tumor biopsy and diagnosed metastatic melanoma;we found distant metastases in the stomach, duodenum, and rectum on endoscopic biopsy...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29105334/genetic-prognostication-in-uveal-melanoma
#8
REVIEW
Mehmet Dogrusöz, Martine J Jager
Uveal melanoma (UM) is a rare tumour with a high propensity to metastasize. Although no effective treatment for metastases yet exists, prognostication in UM is relevant for patient counselling, planning of follow-up and stratification in clinical trials. Besides conventional clinicopathologic characteristics, genetic tumour features with prognostic significance have been identified. Non-random chromosome aberrations such as monosomy 3 and gain of chromosome 8q are strongly correlated with metastatic risk, while gain of chromosome 6p indicates a low risk...
November 4, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29100322/expression-of-ezh2-in-uveal-melanomas-patients-and-associations-with-prognosis
#9
Ying Cheng, Ying Li, Xin Huang, Wenbin Wei, Yi Qu
Purpose: To analyze the prognostic value and potential target for therapeutic intervention of enhancer of zeste homologue 2 (EZH2) in uveal melanomas (UM) patients. Method: We analyzed EZH2 expression in 89 primary UM patients by immuno- histochemistry to observe the clinicopathological and prognostic value of EZH2. Results: The high levels of mitoses count and Ki67 labeling index had significant correlation with overexpression EZH2 (R = 0...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098521/the-results-of-stricter-inclusion-criteria-in-an-immunomagnetic-detection-study-of-micrometastatic-cells-in-bone-marrow-of-uveal-melanoma-patients-relevance-for-dormancy
#10
Nils Eide, Ragnar S Faye, Hanne K Høifødt, Leiv Sandvik, Geir A Qvale, Rowan Faber, Peter Jebsen, Gunnar Kvalheim, Øystein Fodstad
Approximately 50% of uveal melanoma patients develop metastases. We want to evaluate the effect of stricter criteria on our data from our previous study correlating survival and bone marrow (BM) micrometastasis results using our immunomagnetic separation (IMS) method. Mononuclear cell fractions (MNC) isolated from BM were examined for tumour cells and the patients were classified as BM positive (BM+) or BM negative (BM-). The study originally included 328 consecutive patients with uveal melanoma from 1997 to 2006...
November 2, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29095823/long-non-coding-rna-fth1p3-facilitates-uveal-melanoma-cell-growth-and-invasion-through-mir-224-5p
#11
Xiaoli Zheng, Hongwei Tang, Xiaofeng Zhao, Yamei Sun, Yanfang Jiang, Yonghua Liu
Growing evidences indicated that Long noncoding RNAs (lncRNAs) played important roles in tumor initiation and progression. However, the function and mechnism of lncRNA ferritin heavy chain 1 pseudogene 3 (FTH1P3) remain unknown in uveal melanoma. We showed that the expression level of FTH1P3 was upregulated in uveal melanoma cell lines and tissues. Elevated expression of FTH1P3 promoted uveal melanoma cell proliferation, cell cycle and migration. Moreover, we found that FTH1P3 was a direct target gene of miR-224-5p in uveal melanoma cell...
2017: PloS One
https://www.readbyqxmd.com/read/29076951/cisplatin-dacarbazine-and-vinblastine-as-first-line-chemotherapy-for-liver-metastatic-uveal-melanoma-in-the-era-of-immunotherapy-a-single-institution-phase-ii-study
#12
Giovanni Schinzari, Ernesto Rossi, Alessandra Cassano, Vincenzo Dadduzio, Michela Quirino, Monica Pagliara, Maria A Blasi, Carlo Barone
No standard therapy is established for metastatic uveal melanoma. Liver involvement in uveal melanoma may lead to organ impairment, which represents a common cause of death. Tumor shrinkage might improve survival by delaying hepatic failure. Since the combination of cisplatin, vinblastine, dacarbazine allowed a high response rate in metastatic cutaneous melanoma, we explored efficacy and safety of this regimen in unresectable liver metastases of uveal melanoma. In the present phase II study we administered intravenously cisplatin (80 mg/mq, day 1), dacarbazine (250 mg/mq/day, days 1-3), vinblastine (2 mg maximum, day 1) every 21 days as first line treatment for patients with unresectable metastases of uveal melanoma and BRAF wild type...
December 2017: Melanoma Research
https://www.readbyqxmd.com/read/29071269/iodine-125-brachytherapy-for-uveal-melanoma-a-systematic-review-of-radiation-dose
#13
REVIEW
Jose J Echegaray, Nikolaos E Bechrakis, Nakul Singh, Claudine Bellerive, Arun D Singh
AIM: To investigate whether lower radiation doses may yield similar outcome measures to those from the COMS trial. METHODS: A literature review of English language articles was performed using the PubMed database of the U.S. National Library of Medicine and the Cochrane Central Register of Controlled Trials using the following keywords: uveal melanoma, choroidal melanoma, primary uveal malignant melanoma, iodine-125 brachytherapy, local recurrence, local treatment failure, and local tumor control...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29071267/uveal-melanoma-cell-seeding-after-transretinal-tumor-biopsy
#14
Konrad R Koch, Ahmed M Hishmi, Monika Ortmann, Ludwig M Heindl
BACKGROUND/AIMS: To report a case and the histopathology of uveal melanoma cell seeding following transretinal tumor biopsy for a suspected uveal lesion. METHODS: Interventional case report. RESULTS: A 66-year-old male presented with a pigmented perilimbal episcleral lesion overlying an intraocular mass at the pars plana, 3.5 years after transretinal biopsy and ruthenium plaque brachytherapy for a choroidal melanoma at the posterior pole. The patient underwent enucleation of the eye...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29061454/malignant-peripheral-nerve-sheath-tumor-in-a-patient-with-bap1-tumor-predisposition-syndrome-case-report
#15
Megan C Kaszuba, Jose S Pulido, Andrew L Folpe, Pavel N Pichurin, McKinsey L Goodenberger, Robert J Spinner
BACKGROUND: Germline pathogenic variants in BRCA1-associated protein-1 (BAP1), a nuclear ubiquitin carboxy-terminal hydrolase with evidence suggestive of independent tumor suppressor function, predispose affected families to uveal melanoma, cutaneous melanoma, renal cell carcinoma, malignant mesothelioma, and possibly a range of other tumors and malignancies as part of the BAP1 tumor predisposition syndrome (BAP1-TPDS), a recently recognized hereditary cancer syndrome. CASE DESCRIPTION: A 50 year old female patient presented with a malignant peripheral nerve sheath tumor of the left fifth metatarsal head...
October 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29059951/fully-automated-blink-detection-for-uveal-melanoma-radiotherapy
#16
Melih Cavusculu, Imam Samil Yetik, Mete Yeginer
Uveal melanoma is a widespread neoplasm in the eye that cause vision defects. The disease may result in loss of eye, even loss of life with a risk of metastasis to other tissues. There have been proposed various treatment methods to overcome the disease including enucleation and radiotherapy. Radiotherapy treatment is certainly preferable since it avoids the loss of eye. The treatment is applied with radioactive beam directed to the tumor, and thus the eye must be kept steady usually with local anesthesia. However, anesthesia has many health risks; therefore it is preferable to perform this operation without it...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059311/sox10-expression-as-well-as-braf-and-gnaq-11-mutations-distinguish-pigmented-ciliary-epithelium-neoplasms-from-uveal-melanomas
#17
Taisuke Mori, Aoi Sukeda, Shigeki Sekine, Shinsuke Shibata, Eijitsu Ryo, Hideyuki Okano, Shigenobu Suzuki, Nobuyoshi Hiraoka
Purpose: Adenocarcinomas or adenomas derived from pigmented ciliary epithelium (APCE) are exceptionally rare ocular tumors. These tumors have pigmented and epithelioid features, and some APCEs are negative for keratin markers and positive for melanocytic markers. It is especially difficult to distinguish APCEs from uveal melanoma (UM). Accordingly, we examined protein expression and genetic mutations associated with APCE to facilitate diagnosis. Methods: Five APCE and 11 UM samples were obtained from patients during surgical resection at our institute...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29059310/letter-to-the-editor-comparison-of-alternative-tumor-size-classifications-for-posterior-uveal-melanomas
#18
J William Harbour, Manuel Paez-Escamilla
No abstract text is available yet for this article.
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049740/phenotypic-plasticity-in-uveal-melanoma-is-not-restricted-to-a-tumor-subpopulation-and-is-unrelated-to-cancer-stem-cell-characteristics
#19
Rachel E Doherty, Karen Sisley, David W Hammond, Ian G Rennie, Neil A Cross
Purpose: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults and approximately half of those diagnosed will die of metastasis. This study investigates whether UM progression is driven by a subpopulation of stem-like cells, termed "cancer stem cells" (CSCs). Methods: Expression of postulated stem cell markers aldehyde dehydrogenase (ALDH), CD44, and CD133 was analyzed in UM cell lines and primary UM short-term cultures (STCs) established from tumor samples...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29049739/cataract-avoidance-with-proton-therapy-in-ocular-melanomas
#20
Juliette Thariat, Sophie Jacob, Jean-Pierre Caujolle, Celia Maschi, Stéphanie Baillif, Gaelle Angellier, Thibaud Mathis, Laurence Rosier, Adela Carnicer, Joel Hérault, Julia Salleron
Purpose: The lens is a radiosensitive organ. Any dose of cephalic irradiation can give rise to radiation-induced cataracts. Contrary to other forms of radiotherapy, proton therapy (PT) can spare all or part of the lens due to accurate dose deposition. We investigated whether a lens-sparing approach was relevant to avoid cataracts in uveal melanoma patients. Methods: Patients were referred for PT from onco-ophthalmologists of private and academic institutions. Patients without preexisting cataracts or implants were entered in a prospective database...
October 1, 2017: Investigative Ophthalmology & Visual Science
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