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Uveal melanoma

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https://www.readbyqxmd.com/read/28231293/photoacoustic-imaging-features-of-intraocular-tumors-retinoblastoma-and-uveal-melanoma
#1
Guan Xu, Yafang Xue, Zeynep Gürsel Özkurt, Naziha Slimani, Zizhong Hu, Xueding Wang, Kewen Xia, Teng Ma, Qifa Zhou, Hakan Demirci
The purpose of this study is to examine the capability of photoacoustic (PA) imaging (PAI) in assessing the unique molecular and architectural features in ocular tumors. A real-time PA and ultrasonography (US) parallel imaging system based on a research US platform was developed to examine retinoblastoma in mice in vivo and human retinoblastoma and uveal melanoma ex vivo. PA signals were generated by optical illumination at 720, 750, 800, 850, 900 and 950 nm delivered through a fiber optical bundle. The optical absorption spectra of the tumors were derived from the PA images...
2017: PloS One
https://www.readbyqxmd.com/read/28230715/a-multireferral-centre-retrospective-cohort-analysis-on-the-experience-in-treatment-of-metastatic-uveal-melanoma-and-utilization-of-sequential-liver-directed-treatment-and-immunotherapy
#2
Malinda Itchins, Paolo A Ascierto, Alexander M Menzies, Meredith Oatley, Serigne Lo, Dariush Douraghi-Zadeh, Timmothy Harrington, Richard Maher, Antonio M Grimaldi, Alexander Guminski
Metastatic uveal melanoma is a rare malignancy with a poor prognosis. To date, systemic therapy has been ineffective; however, there are few data on the benefits of anti-CTLA4 or anti-PD-1 antibodies in sequence with liver-directed therapy. A retrospective cohort analysis was carried out on 37 consecutive patients managed in a tertiary referral centre examining the safety and efficacy of treatment; patterns of care; and impact on survival. The sequential treatment with transarterial chemotherapy (TAC), systemic immunotherapy (IT) and systemic chemotherapy was reviewed...
February 22, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28229253/the-biology-of-uveal-melanoma
#3
Adriana Amaro, Rosaria Gangemi, Francesca Piaggio, Giovanna Angelini, Gaia Barisione, Silvano Ferrini, Ulrich Pfeffer
Uveal melanoma (UM), a rare cancer of the eye, is distinct from cutaneous melanoma by its etiology, the mutation frequency and profile, and its clinical behavior including resistance to targeted therapy and immune checkpoint blockers. Primary disease is efficiently controlled by surgery or radiation therapy, but about half of UMs develop distant metastasis mostly to the liver. Survival of patients with metastasis is below 1 year and has not improved in decades. Recent years have brought a deep understanding of UM biology characterized by initiating mutations in the G proteins GNAQ and GNA11...
February 22, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28228113/validation-of-an-ngs-mutation-detection-panel-for-melanoma
#4
Anne Reiman, Hugh Kikuchi, Daniela Scocchia, Peter Smith, Yee Wah Tsang, David Snead, Ian A Cree
BACKGROUND: Knowledge of the genotype of melanoma is important to guide patient management. Identification of mutations in BRAF and c-KIT lead directly to targeted treatment, but it is also helpful to know if there are driver oncogene mutations in NRAS, GNAQ or GNA11 as these patients may benefit from alternative strategies such as immunotherapy. METHODS: While polymerase chain reaction (PCR) methods are often used to detect BRAF mutations, next generation sequencing (NGS) is able to determine all of the necessary information on several genes at once, with potential advantages in turnaround time...
February 22, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28223438/dysregulated-gpcr-signaling-and-therapeutic-options-in-uveal-melanoma
#5
Vivian Chua, Dominic Lapadula, Clinita Randolph, Jeffrey L Benovic, Philip Wedegaertner, Andrew E Aplin
: Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults and arises from the transformation of melanocytes in the uveal tract. Even after treatment of the primary tumor, up to 50% of patients succumb to metastatic disease. The liver is the predominant organ of metastasis. There is an important need to provide effective treatment options for advanced stage UM. In order to provide the preclinical basis for new treatments, it is important to understand the molecular underpinnings of the disease...
February 21, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28218368/intravitreal-dexamethasone-implant-ozurdex%C3%A2-for-exudative-retinal-detachment-after-proton-beam-therapy-for-choroidal-melanoma
#6
Ariane Malclès, Anh-Minh Nguyen, Thibaud Mathis, Jean-Daniel Grange, Laurent Kodjikian
PURPOSE: To evaluate the efficacy and safety of intravitreal 0.7-mg dexamethasone implant (DEX-I) (Ozurdex®) in the treatment of extensive exudative retinal detachment (RD) associated with uveal melanoma treated using proton beam therapy (PBT). METHODS: Data from 10 patients with exudative RD after PBT treated with intravitreal injection of 0.7-mg DEX-I were reviewed retrospectively. The main outcome measures were resolution of exudative RD, visual acuity, and safety profile...
February 8, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28203054/uveal-melanoma-epidemiology-etiology-and-treatment-of-primary-disease
#7
REVIEW
Benjamin A Krantz, Nikita Dave, Kimberly M Komatsubara, Brian P Marr, Richard D Carvajal
Uveal melanoma (UM) is the most common intraocular malignancy and arises from melanocytes in the iris, ciliary body, or choroid. Early diagnosis and local treatment is crucial, as survival correlates with primary tumor size. However, approximately 50% of patients will develop metastatic disease with 6-12 months' survival from metastatic diagnosis. Genomic analyses have led to the development of gene-expression profiles that effectively predict metastatic progression; unfortunately, no adjuvant therapy has been shown to prolong survival to date...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28203052/early-experiences-of-planning-stereotactic-radiosurgery-using-3d-printed-models-of-eyes-with-uveal-melanomas
#8
Alena Furdová, Miron Sramka, Andrej Thurzo, Adriana Furdová
OBJECTIVE: The objective of this study was to determine the use of 3D printed model of an eye with intraocular tumor for linear accelerator-based stereotactic radiosurgery. METHODS: The software for segmentation (3D Slicer) created virtual 3D model of eye globe with tumorous mass based on tissue density from computed tomography and magnetic resonance imaging data. A virtual model was then processed in the slicing software (Simplify3D(®)) and printed on 3D printer using fused deposition modeling technology...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28192844/-potentials-and-limitations-of-the-detection-of-circulating-melanoma-cells
#9
J Lüke, S Grisanti, A Tura
The detection and characterisation of circulating melanoma cells (CMC) is a non-invasive procedure with a low complication rate and can potentially distinguish choroidal nevi from uveal melanomas and help to initiate early adequate therapy. It has the perspective to select and monitor treatment. This technique may lead to new insights into the metastasis process itself and help to detect specific targets for future therapies. This article introduces the different techniques for CMC detection; their potentials and limitations are discussed...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28185660/treatment-plan-optimization-and-robustness-of-106-ru-eye-plaque-brachytherapy-using-a-novel-software-tool
#10
Gerd Heilemann, Lukas Fetty, Martin Dulovits, Matthias Blaickner, Nicole Nesvacil, Dietmar Georg, Roman Dunavoelgyi
BACKGROUND AND PURPOSE: To analyze treatment plan robustness and plan optimization strategies of (106)Ru eye plaque brachytherapy using a novel software tool. MATERIALS AND METHODS: A treatment planning software was developed that allows to calculate dose-volume metrics. Plaque misplacements were simulated and evaluated with respect to the effect on tumor coverage and dose changes in critical structures. Two treatment plan optimization approaches were analyzed: (a) reducing plaque size and (b) shifting the plaque away from organs-at-risk (OAR)...
February 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28163118/local-failure-after-episcleral-brachytherapy-for-posterior-uveal-melanoma-patterns-risk-factors-and-management
#11
Claudine Bellerive, Hassan A Aziz, James Bena, Allan Wilkinson, John H Suh, Thomas Plesec, Arun D Singh
IMPORTANCE: A small percentage of patients with uveal melanoma will experience local recurrence following brachytherapy. An understanding of the recurrence patterns can improve early recognition and management of local treatment failure. OBJECTIVE: To evaluate the patterns, the risk factors and the management of recurrence following brachytherapy in patients with posterior uveal melanoma. DESIGN: Retrospective cohort study. SETTING: Multispecialty tertiary care center...
February 2, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28159971/the-prognostic-value-of-ajcc-staging-in-uveal-melanoma-is-enhanced-by-adding-chromosome-3-and-8q-status
#12
Mehmet Dogrusöz, Mette Bagger, Sjoerd G van Duinen, Wilma G Kroes, Claudia A L Ruivenkamp, Stefan Böhringer, Klaus Kaae Andersen, Gregorius P M Luyten, Jens F Kiilgaard, Martine J Jager
Purpose: The American Joint Committee on Cancer (AJCC) staging system has been validated for use as a prognostic parameter in uveal melanoma (UM). We studied whether adding information regarding chromosome 3 and 8q status further enhances the prognostic value of this staging system. Methods: We retrospectively studied a cohort of 522 patients who had been treated for UM in two different centers between 1999 and 2015. The mean follow-up time was 47.7 months. Cumulative incidence curves were generated and regression analyses were performed for different combinations of AJCC staging and chromosome status...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28159770/ultrasonic-mirror-image-from-ruthenium-plaque-facilitates-calculation-of-uveal-melanoma-treatment-dose
#13
Charlotte Alfast Espensen, Peter Koch Jensen, Lotte Stubkjær Fog, Ane Lindegaard Appelt, Kristian Klemp, Hans Callø Fledelius, Lena Specht, Jens Folke Kiilgaard
BACKGROUND/AIMS: To present a new method to determine dose depth and the distance from the concave side of the plaque to the tumour base in patients with uveal melanoma treated with ruthenium-106 based on ultrasonic mirror image. METHODS: We used the mirror image associated with ultrasound during plaque brachytherapy to determine intraobserver reproducibility and interobserver agreement between two surgeons. 230 eyes with primary uveal melanoma were included in a retrospective analysis to determine the distance from the plaque to the tumour base using ultrasound...
February 3, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28159633/ring-melanoma-of-the-anterior-chamber-angle-as-a-mimicker-of-pigmentary-glaucoma
#14
Anni Stadigh, Päivi Puska, Eija Vesti, Ari Ristimäki, Joni A Turunen, Tero T Kivelä
A 19-year-old man noticed blurred vision in his right eye. He had an intraocular pressure (IOP) of 60 mmHg, versus 12 mmHg in the fellow eye. He was initially diagnosed with an atypical, advanced pigmentary glaucoma. The IOP did not respond to maximal medication, deep sclerectomy, goniopuncture, and two cyclophotocoagulations. Sixteen months after presentation, malignancy was first suspected, and the eye was enucleated. A ring melanoma of the anterior chamber angle was confirmed by the histopathological examination...
January 31, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28159380/cytogenetic-abnormalities-in-uveal-melanoma-based-on-tumor-features-and-size-in-1059-patients-the-2016-w-richard-green-lecture
#15
Carol L Shields, Emil Anthony T Say, Murat Hasanreisoglu, Jarin Saktanasate, Brendan M Lawson, Jeffrey E Landy, Anjali U Badami, Meera D Sivalingam, Arman Mashayekhi, Jerry A Shields, Arupa Ganguly
PURPOSE: To determine the risks for altered cytogenetic profile based on melanoma features and size. DESIGN: Retrospective case series. PARTICIPANTS: A total of 1059 patients with uveal melanoma. METHODS: Fine-needle aspiration biopsy (FNAB) of tumor for DNA amplification and whole genome array-based assay. MAIN OUTCOME MEASURES: Risk for cytogenetic abnormalities based on features and size: small (≤3 mm thickness), medium (>3-<8 mm), and large (≥8 mm)...
January 31, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28144882/efficacy-and-toxicity-of-transarterial-chemoembolization-therapy-using-cisplatin-and-gelatin-sponge-in-patients-with-liver-metastases-from-uveal-melanoma-in-an-asian-population
#16
Yoshitsugu Shibayama, Kenjiro Namikawa, Miyuki Sone, Akira Takahashi, Arata Tsutsumida, Shunsuke Sugawara, Yasuaki Arai, Yukiko Aihara, Shigenobu Suzuki, Juichiro Nakayama, Shinichi Imafuku, Naoya Yamazaki
BACKGROUND: Although both immune-checkpoint inhibitors and targeted therapies such as MEK inhibitors have been evaluated in metastatic uveal melanoma, the efficacy of these therapies is modest to date. The purpose of this study was to evaluate the efficacy and toxicity of transarterial chemoembolization (TACE) therapy for liver metastasis from uveal melanoma in an Asian population. METHODS: We retrospectively assessed the clinical data of patients with liver metastases from uveal melanoma who received TACE therapy using cisplatin (70 mg/m(2)) and gelatin sponge between 1997 and 2008...
January 31, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28144756/percutaneous-isolated-hepatic-perfusion-as-a-treatment-for-isolated-hepatic-metastases-of-uveal-melanoma-patient-outcome-and-safety-in-a-multi-centre-study
#17
Thomas J Vogl, Silvia A Koch, Gösta Lotz, Bernhard Gebauer, Winfried Willinek, Christoph Engelke, Roland Brüning, Martin Zeile, Frank Wacker, Arndt Vogel, Boris Radeleff, Jan-Erik Scholtz
PURPOSE: Percutaneous isolated hepatic perfusion (PIHP) with Melphalan has been developed as a treatment for patients with isolated hepatic metastases of uveal melanoma. We discuss patient outcome and safety in a retrospective multi-centre study. MATERIALS AND METHODS: Between 2012 and 2016 18 patients with un-resectable isolated hepatic metastases of uveal melanoma received single or repeated PIHP with Melphalan (n = 35) at seven sites. Progression-free time, overall survival time (OS) and tumour response by means of RECIST 1...
January 31, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28141766/choroidal-nevus-a-review-of-prevalence-features-genetics-risks-and-outcomes
#18
Jason L Chien, Kareem Sioufi, Thamolwan Surakiatchanukul, Jerry A Shields, Carol L Shields
PURPOSE OF REVIEW: To review the prevalence, clinical features, imaging findings, cytogenetics, and risks and outcomes of choroidal nevus. RECENT FINDINGS: Choroidal nevus is a benign melanocytic tumor, often discovered incidentally on ophthalmic examination. This lesion is generally well circumscribed and pigmented. The prevalence of choroidal nevus in postequatorial region in United States adults (≥40 years old) is approximately 5%. Choroidal nevus is associated with higher lifetime unopposed estrogen and greater BMI...
January 30, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28140525/nanobodies-against-surface-biomarkers-enable-the-analysis-of-tumor-genetic-heterogeneity-in-uveal-melanoma-patient-derived-xenografts
#19
Ronan Crépin, David Gentien, Angeline Duché, Audrey Rapinat, Cecile Reyes, Fariba Némati, Gérald Massonnet, Didier Decaudin, Selma Djender, Sandrine Moutel, Klervi Desrumeaux, Nathalie Cassoux, Sophie Piperno-Neumann, Sebastian Amigorena, Franck Perez, Sergio Roman Roman, Ario de Marco
Monoclonal antibodies specific for biomarkers expressed on the surface of uveal melanoma (UM) cells would simplify the immune-capture and genomic characterization of heterogeneous tumor cells originated from patient derived xenografts (PDXs). Antibodies against four independent tumor antigens were isolated by panning a nanobody synthetic library. Such antibodies enabled flow-cytometry-based sorting of distinct cell sub-populations from UM PDXs and to analyze their genomic features. The complexity and specificity of the biochemical and genomic biomarker combinations mirrored the UM tumor polyclonality...
January 31, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28138035/co-targeting-hgf-cmet-signaling-with-mek-inhibitors-in-metastatic-uveal-melanoma
#20
Hanyin Cheng, Vivian Chua, Connie Liao, Timothy J Purwin, Mizue Terai, Ken Kageyama, Michael A Davies, Takami Sato, Andrew E Aplin
Metastatic uveal melanoma (UM) patients usually die within one year of diagnosis, emphasizing an urgent need to develop new treatment strategies. The liver is the most common site of metastasis. Mitogen-activated protein kinase kinase (MEK) inhibitors improve survival in V600 BRAF-mutated cutaneous melanoma patients but have limited efficacy in UM patients. Our previous work showed that HGF signaling elicits resistance to MEK inhibitors in metastatic UM. In this study, we demonstrate that expression of two BH3-only family proteins, Bim-EL and BMF, contributes to HGF-mediated resistance to MEK inhibitors...
January 30, 2017: Molecular Cancer Therapeutics
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