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Choroidal melanoma

A F Brovkina, Y N Khionidi
Complications and the frequency of their occurrence as the criteria of eye preservation after brachytherapy (BT) are presented in literature with inconsistencies due to the assessment being done after varied follow-up periods (1 month to 5-10 years). The evaluation of complications occurring after applying radioiodine can be found in literature. The complications after BT beta particle emitting ophthalmic applicators are seldom discussed in articles. PURPOSE: to examine the frequency of complications, the characteristics of their development after choroidal melanoma (CM) brachytherapy with ruthenium ophthalmic applicators (OA) during long-term follow-up and determine the possibility of their prevention...
2018: Vestnik Oftalmologii
Pietro Diana, Charoen Mankongpaisarnrung, Michael B Atkins, Jay C Zeck, Aline Charabaty
We report a 62-year-old white woman with metastatic choroidal melanoma who developed immune checkpoint inhibitor (ICI)-induced enteritis and grade 3 diarrhea refractory to steroids and infliximab. Her diarrhea quickly resolved after infusion of vedolizumab, and the patient was able to taper down steroids. Vedolizumab's mechanism of action and its gut specificity have the potential to reverse immune-induced enterocolitis without neutralizing or reversing the therapeutic benefit of ICI on the malignancy.
2018: ACG Case Reports Journal
Qu-Knafo Lise, Auregan-Giocanti Audrey
Purpose: To report a case of bilateral panuveitis with multifocal choroiditis associated with a systemic sarcoidosis unmasked by pembrolizumab. Case report: A 68-years old woman with a history of metastatic melanoma treated by pembrolizumab consulted for bilateral blurred vision. The ophthalmologic examination revealed a bilateral anterior uveitis with cells in the anterior chamber and granulomatous keratic precipitates, vitreous cells and multifocal choroiditis confirmed by indocyanine green angiography...
April 2017: American Journal of Ophthalmology Case Reports
Mamunur Rashid, Jorma Heikkonen, Arun D Singh, Tero T Kivelä
PURPOSE: To build multivariate models to assess correctly and efficiently the contribution of tumor characteristics on the rate of regression of choroidal melanomas after brachytherapy in a way that adjusts for confounding and takes into account variation in tumor regression patterns. DESIGN: Modeling of longitudinal observational data. PARTICIPANTS: Ultrasound images from 330 of 388 consecutive choroidal melanomas (87%) irradiated from 2000 through 2008 at the Helsinki University Hospital, Helsinki, Finland, a national referral center...
February 27, 2018: Ophthalmology
Ilkay Kilic Muftuoglu, Raouf Gaber, Dirk-Uwe Bartsch, Amit Meshi, Michael Goldbaum, William R Freeman
PURPOSE: Our purpose was to compare the characteristics of the retinal and choroidal lesions including choroidal nevus, choroidal melanoma and congenital hypertrophy of the retina pigment epithelium using conventional color fundus photography (CFP) and multicolor imaging (MCI). METHODS: The paired images of patients with retinal or choroidal lesions were assessed for the visibility of lesion's border, halo and drusen using a grading scale (0-2). The area of the lesion was measured on both imaging modalities...
February 28, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Raksha Rao, Elif B Turkoglu, Emil A T Say, Carol L Shields
PURPOSE: To evaluate the natural history of myelinated retinal nerve fiber layer (MRNFL) through clinical features and enhanced depth imaging optical coherence tomography. METHODS: This is a retrospective, noncomparative, case series of patients who underwent thorough clinical examination to document associated ocular and systemic features. Enhanced depth imaging optical coherence tomography was performed when MRNFL was located posteriorly and accessible to imaging...
February 13, 2018: Retina
Ido Didi Fabian, Andrew W Stacey, Lamis Al Harby, Amit K Arora, Mandeep S Sagoo, Victoria M L Cohen
AIMS: To investigate the outcomes of primary photodynamic therapy (PDT) for pigmented posterior pole cT1a choroidal melanoma. METHODS: Retrospective interventional consecutive case series of 26 patients (26 eyes) with pigmented posterior pole cT1a choroidal melanoma, who were treated with 3 sessions of PDT and followed-up thereafter. RESULTS: Included were 11 males and 15 females that presented at a median age of 66 years (mean: 64) with transformed naevi (n=11) or suspicious lesions (n=15) with ≥3 risk factors for growth, with lipofuscin in all...
February 13, 2018: British Journal of Ophthalmology
Abhilasha Maheshwari, Paul T Finger
PURPOSE: To present our 12-year experience with low energy photon, slotted eye plaque radiation therapy. DESIGN: Retrospective interventional case series METHODS: SETTING: The New York Eye Cancer Center. STUDY POPULATION: Fifty-two consecutive patients with uveal melanomas near, touching or surrounding the optic disc. INTERVENTION: Slotted eye plaque radiation therapy. MAIN OUTCOME MEASURES: change in visual acuity, local tumor control, radiation side effects, eye salvage and systemic metastases...
January 31, 2018: American Journal of Ophthalmology
Fariba Ghassemi, Reza Mirshahi, Kaveh Fadakar, Siamak Sabour
Synopsis: In optical coherence tomography angiography, the choroidal vascular flow rate in choroidal melanoma is significantly lower than that in choroidal nevus. Objective: The objective of this study was to describe the choriocapillaris and retinal features imaged by optical coherence tomography angiography (OCTA) in eyes with choroidal nevus from small malignant choroidal melanoma. Methods: In this retrospective, noninvasive, observational study, 11 patients diagnosed with small choroidal mass (five with choroidal nevus and six with malignant melanoma) who underwent dilated fundus examination, ocular ultrasonography and OCTA images were compared...
2018: Clinical Ophthalmology
Marcelino Hermida-López, Lorenzo Brualla
PURPOSE: Brachytherapy with106 Ru/106 Rh plaques offers good outcomes for small-to-medium choroidal melanomas and retinoblastomas. The dose measurement of the plaques is challenging, due to the small range of the emitted beta particles and steep dose gradients involved. The scarce publications on film dosimetry of106 Ru/106 Rh plaques used solid phantoms. This work aims to develop a practical method for measuring the absorbed dose distribution in water produced by106 Ru/106 Rh plaques using EBT3 radiochromic film...
February 5, 2018: Medical Physics
Inder K Daftari, Jeanne M Quivey, Jennifer S Chang, Kavita K Mishra
PURPOSE: The purpose of this study is to explore the feasibility of the use of titanium fiducial markers to minimize the metallic artifact seen with tantalum markers which causes significant distortion on postoperative orbital CT scans. METHOD: We designed and constructed the titanium markers in the shop of Crocker Nuclear Laboratory, UC Davis, CA. The markers were placed on an eyeball phantom. The eyeball was inserted into the Rando phantom in the orbital space...
January 29, 2018: Medical Physics
Yi-Chieh Tsai, Chun-Yuan Kuo, Jia-Wei Lin, Shun-Tai Yang, Shih-Chung Lai, Jo-Ting Tsai
Radiosurgery serves an important function in the treatment of patients with intraocular tumors and preserves visual function via organ conservation. Therefore, it is important to ensure the safety and precision of GK-SRS as a primary treatment for intraocular tumors. The present case study described a 57-year-old female with uveal melanoma treated with GK-SRS. Retrobulbar anesthesia following fixation of the treated eye, via the suture of two of the extraocular muscles to the stereotactic frame, was performed to immobilize the eye during treatment...
January 2018: Oncology Letters
Natasha M van Poppelen, Jolanda Vaarwater, Hardeep S Mudhar, Karen Sisley, Ian G Rennie, Paul Rundle, Tom Brands, Quincy C C van den Bosch, Hanneke W Mensink, Annelies de Klein, Emine Kiliç, Robert M Verdijk
PURPOSE: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Iris melanoma comprises 4% to 10% of all UMs and has a lower mortality rate. The genetic changes in iris melanoma are not as well characterized as ciliary body or choroidal melanoma. The aim of this study was to gain more insight into the genetic background of iris melanoma and iris nevi. DESIGN: Multicenter, retrospective case series. PARTICIPANTS: Patients diagnosed with iris melanoma or iris nevi who underwent surgical intervention as primary or secondary treatment...
January 19, 2018: Ophthalmology
Debarshi Mustafi, Bertil Damato, Jesse L Berry
We report a case of multifocal choroidal melanoma in the same eye, separated in presentation by 20 years. A 57-year-old Caucasian male initially presented with a choroidal melanoma of the right eye that was treated with transpupillary thermotherapy. Due to recurrence, the patient underwent proton beam therapy with subsequent tumor regression. A second small choroidal lesion was noted in the right eye during his surveillance examinations that was closely monitored and demonstrated stable dimensions and features suggestive of a choroidal nevus...
December 2017: Ocular Oncology and Pathology
Hidetsugu Mori, Kanji Takahashi
Purpose: Retinal pigment epithelium (RPE) adenocarcinoma is a very rare malignant intraocular tumor. Herein we describe the histopathological features of RPE adenocarcinoma. Case: A 36-year-old male was referred to our clinic because of floaters in his left eye. The initial diagnosis was malignant melanoma of the choroid. We resected the tumor and studied it histopathologically. The tumor tissue was investigated by light microscopy including immunohistochemistry using antibodies against S-100, HMB-45, EMA, and AE-1...
December 2017: Ocular Oncology and Pathology
Chris B Komanski, Shaina M Rubino, Jacob C Meyer, Craig M Greven
Choroidal melanoma is the most common primary intraocular malignancy, yet metastatic disease remains the most common malignancy of the eye. Differentiating these entities is essential as treatment, systemic associations, and prognosis vary dramatically between the two. Established diagnostic criteria are accurate for the diagnosis of uveal melanoma. Yet, metastatic disease may be misdiagnosed as a uveal melanoma in rare cases. We report a case of metastatic clear-cell renal cell carcinoma masquerading as uveal melanoma...
November 2017: Ocular Oncology and Pathology
Eszter Szalai, Jill R Wells, Hans E Grossniklaus
Aim: The aim of this study was to assess morphological risk factors associated with optic nerve invasion of choroidal melanoma and to identify possible mechanisms of optic nerve invasion. Methods: Medical charts and histology slides of patients with primary choroidal melanoma who were treated by enucleation/exenteration and whose pathology showed optic nerve invasion were reviewed. Results: Twenty-one patients (mean age: 65.67 ± 14.72 years) with primary uveal melanoma arising from the choroid were included in this analysis...
November 2017: Ocular Oncology and Pathology
Zujaja Tauqeer, Frederick A Jakobiec, Suzanne K Freitag, Michael K Yoon, Natalie Wolkow
PURPOSE: To present 2 patients in whom orbital radiation preceded the development of periorbital extranodal marginal zone lymphoma by more than a decade and to investigate the likelihood of this representing irradiation-induced malignancy. METHODS: Retrospective chart review and histopathologic study with immunohistochemistry of 2 cases. RESULTS: The first patient was a 58-year-old woman who developed an orbital mass within the vicinity of the lateral rectus muscle 17 years after external beam proton radiation therapy for an inferotemporal choroidal melanoma...
January 9, 2018: Ophthalmic Plastic and Reconstructive Surgery
Hasan Danish, Matthew J Ferris, Ehsan Balagamwala, Jeffrey M Switchenko, Kirtesh R Patel, Maria Choudhary, Caroline Craven, Pia Mendoza, John Suh, Chris Bergstrom, Hans E Grossniklaus, Thomas M Aaberg, Arun Singh, Ian R Crocker, Mohammad K Khan
For the treatment of choroidal melanoma, palladium-103 (Pd) and ruthenium-106 (Ru) plaque brachytherapy shows reduced toxicity compared with the historical standard iodine-125. No report has directly compared the clinical outcomes between Pd and Ru, and the reasons for the selection of one over the other remain purely theoretical. Patients with choroidal melanoma with apical tumor height up to 5 mm were included. Patients from Emory University were treated with Pd between 1993 and 2012. Patients from Cleveland Clinic were treated with Ru between 2005 and 2010...
April 2018: Melanoma Research
Brijesh Takkar, Kabiruddin Molla, Pradeep Venkatesh
Optic disc melanocytoma (ODM) has been considered as a benign tumor with few reports of malignant transformation. We present swept-source optical coherence tomography (SSOCT) imaging of a case of ODM. As attaining histopathology is impossible in most cases, we discuss the possibility of using SSOCT as a tool for ruling out choroidal invasion or juxtapapillary melanoma.
January 2018: Indian Journal of Ophthalmology
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