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Choroidal melanoma

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https://www.readbyqxmd.com/read/29772919/erythema-nodosum-as-the-initial-presentation-of-nivolumab-induced-sarcoidosis-like-reaction
#1
Alexandre Laroche, Evelyn Alarcon Chinchilla, Emilie Bourgeault, Marc-André Doré
BACKGROUND: We report a case of nivolumab-related sarcoidosis-like syndrome that initially presented with erythema nodosum. Sarcoidosis development has been described in single and combination immunotherapy. CASE PRESENTATION: A 68-year-old white woman with metastatic ocular amelanotic choroid melanoma was treated with nivolumab. The patient developed histologically confirmed erythema nodosum lesions and pulmonary granuloma sarcoidosis. Nivolumab was discontinued and the patient started ipilimumab therapy...
May 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29772048/palladium-103-brachytherapy-for-choroidal-melanoma-in-a-pregnant-woman
#2
Ekaterina Semenova, Paul T Finger, Nina Kalach, Walter Choi
The authors present a case of a pregnant woman with uveal melanoma treated with plaque brachytherapy. Her calculated fetal radiation dose was significantly below accepted levels. The use of the authors' novel, custom-made lead chin shield further diminished irradiation of the fetus. This patient had uncomplicated treatment course, delivered a healthy child full term, achieved local tumor control, and maintained 20/25 vision at 1-year follow-up. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:364-368.].
May 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29765944/uveal-melanoma-5-year-update-on-incidence-treatment-and-survival-seer-1973-2013
#3
Mary E Aronow, Allan K Topham, Arun D Singh
Purpose: To analyze trends in incidence, treatment, and survival of uveal melanoma in the United States from 1973 to 2013 using the Surveillance, Epidemiology, and End Results database. Materials and Methods: Patients were identified using International Classification of Disease for Oncology codes: C69.3 (choroid), C69.4 (ciliary body and iris), and C69.2 (retina). Trends in age-adjusted incidence, treatment (surgery or radiation), and 5-year relative survival were calculated...
April 2018: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29755268/cytogenetic-results-of-choroidal-nevus-growth-into-melanoma-in-55-consecutive-cases
#4
Carol L Shields, Maria Pefkianaki, Arman Mashayekhi, Jerry A Shields, Arupa Ganguly
Purpose: To investigate the cytogenetic results of choroidal nevus with photographically-documented transformation into choroidal melanoma. Methods: Retrospective analysis of 55 consecutive patients who underwent fine needle aspiration biopsy (FNAB) for DNA isolation and whole genome array based assay for chromosomes 3, 6, and 8 analysis prior to plaque radiotherapy. Tumors with abnormalities in chromosomes 3 and 8 were considered high-risk for metastasis. Results: At diagnosis of choroidal nevus the mean patient age was 57 years (median 57, range 10-83 years)...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29747872/early-ultrasonographic-tumor-regression-after-linear-accelerator-stereotactic-fractionated-photon-radiotherapy-of-choroidal-melanoma-as-a-predictor-for-metastatic-spread
#5
Christoph Mitsch, Martin Zehetmayer, Andreas Gleiss, Dietmar Georg, Karin Dieckmann, Richard Pötter, Ramzi Sayegh, Ursula Schmidt-Erfurth, Roman Dunavoelgyi
BACKGROUND AND PURPOSE: During extended follow-up (of up to 15 years), approximately fifty percent of patients with choroidal melanoma will develop metastatic disease and eventually die. Thus, continuing research on prognostic factors, early detection and treatment is necessary. Height regression rates both after plaque brachytherapy and proton beam irradiation have been shown to have prognostic value. The purpose of this study was to analyze the influence of early tumor regression rate after treatment of choroidal melanoma with LINAC stereotactic fractionated radiotherapy (SFRT) as an independent risk factor for metastasis...
May 8, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29746413/intravitreal-anti-vascular-endothelial-growth-factor-treatment-at-2-month-intervals-reduces-foveal-avascular-zone-enlargement-and-vision-loss-in-radiation-maculopathy-a-pilot-study
#6
Alejandra Daruich, Alexandre Matet, Ann Schalenbourg, Leonidas Zografos
PURPOSE: To evaluate, in eyes with radiation maculopathy, the effect of 2-month-interval anti-vascular endothelial growth factor therapy on best-corrected visual acuity and foveal avascular zone (FAZ) enlargement using optical coherence tomography angiography. METHODS: Consecutive treatment-naive patients with radiation maculopathy after proton beam irradiation for choroidal melanoma were retrospectively included. Clinical and optical coherence tomography angiography data at baseline and the 6-month visit were recorded...
May 3, 2018: Retina
https://www.readbyqxmd.com/read/29738013/atypical-posterior-scleritis-mimicking-choroidal-melanoma
#7
Heba M Alsharif, Saad A Al-Dahmash
We report a case of atypical posterior scleritis mimicking amelanotic choroidal melanoma. A 30-year-old healthy Filipino man, with a history of painless subacute loss of vision in his left eye over 5 months, was referred to our institute for further workup and management. On examination, visual acuity of the left eye was 20/200. Anterior segment examination yielded unremarkable results, with injected conjunctiva and quiet episcleral blood vessels, while fundus examination revealed non-pigmented nasal choroidal mass, with significant subretinal fluid resembling amelanotic choroidal melanoma...
May 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29715140/depression-in-choroidal-melanoma-patients-treated-with-proton-beam-radiotherapy
#8
Marilita M Moschos, Giannis A Moustafa, Anastasios Lavaris, Christos Damaskos, Konstantinos Laios, Ekaterini Karathanou, Dimitrios S Ladas, Ioannis Asproudis, Nikolaos Garmpis, Christos Kalogeropoulos
AIM: To determine depression in patients with choroidal melanoma (CM) treated with proton beam radiotherapy. PATIENTS AND METHODS: This was a cross-sectional study including 50 patients with CM (50% males, mean age=49.88±6.34 years) and 46 age- and sex-matched healthy controls (52% males, mean age=48.60±8.05 years). Participants completed the Patient Health Questionnaire-9 (PHQ-9) and the Zung Self-Rating Depression Scale (SDS) questionnaires. RESULTS: There was a considerable difference in visual acuity as logarithm of the minimum angle of resolution (logMAR) between the patient and control groups (1...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29707895/gamma-irradiation-of-ocular-melanoma-and-lymphoma-cells-in-the-presence-of-gold-nanoparticles-in-vitro-study
#9
Mozhgan Rezaei Kanavi, Somayeh Asadi, Sahar Balagholi, Fatemeh Alikarami, Hassan Nosrati, Hamid Ahmadieh
The aim of this work was to determine whether conjugation of cultivated choroidal melanoma and Burkitt's lymphoma cells with gold nanoparticles (GNPs) is beneficial for these series of ocular cancer patients. GNPs are radiosensitizers and can sensitize tumors to radiotherapy.This application has been examined in several tumor types, but not in choroidal melanoma. This study shows the results of in vitro study on the choroidal melanoma and also Burkitt's lymphoma cells in the presence of GNPs during continuous gamma irradiation...
April 29, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29687085/orbital-melanocytoma-when-a-tumor-becomes-a-relieving-surprise
#10
Haytham E Nasr, Mohamed A Nouh, Rania A Ahmed, Abdelrahman M Elhusseiny
Purpose: Melanocytomas are rare pigmented tumors that arise form melanocytes and have been reported in the central nervous system. Orbital melanocytomas "also known as blue nevus" are rarely reported. The occurrence of choroidal melanoma and orbital melanocytomas has never been described. Observations: This is a case of orbital melanocytoma in a 34 year old female who presented with left proptosis and ecchymosis. She has the right eye enucleated to treat a large choroidal melanoma, 6 years earlier...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29681297/predicting-choroidal-melanoma-regression-after-brachytherapy
#11
EDITORIAL
Bertil Damato
No abstract text is available yet for this article.
May 2018: Ophthalmology
https://www.readbyqxmd.com/read/29680322/dose-response-in-choroidal-melanoma
#12
Alex De Caluwé, Karolien Termote, Dirk Van Gestel, Erik Van Limbergen
PURPOSE: In choroidal melanoma the radiation threshold dose for local control remains largely unknown. The present study examined a group of patients that received a wide range of minimum tumor dose in order to investigate a dose-response relationship. A literature review is performed to compare our results with available evidence in brachytherapy and charged particle external beam radiotherapy. MATERIALS AND METHODS: A retrospective study was conducted on all choroidal melanomas treated with Strontium-90 (Sr-90) at the University Hospital of Leuven between 1983 and 2012...
April 18, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29672247/management-of-chronic-hypotony-following-bilateral-uveitis-in-a-patient-treated-with-pembrolizumab-for-cutaneous-metastatic-melanoma
#13
Gerard Reid, Paul Lorigan, Heinrich Heimann, Marta Hovan
PURPOSE: To describe the presentation and management of severe ocular adverse events following treatment with pembrolizumab for cutaneous metastatic melanoma. METHODS: Interventional case report. RESULTS: A 73-year-old Caucasian man receiving pembrolizumab treatment for metastatic melanoma presented with panuveitis and subsequent profound hypotony, choroidal effusions, and optic disk swelling bilaterally. Oral prednisolone controlled intraocular inflammation...
April 19, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29663723/intraocular-metastasis-of-medullary-thyroid-carcinoma-investigated-by-transscleral-fine-needle-aspiration-a-case-report-and-review-of-the-literature
#14
Małgorzata Gajdzis, Nathalie Cassoux, Maria Lesnik, Caroline Hoffmann, Nathalie Badois, Paweł Gajdzis, Jerzy Klijanienko
Medullary thyroid carcinoma occurs in a sporadic setting and may also be inherited in an autosomal dominant fashion, which is related with germline mutations of the RET gene. Metastases are often present at the time of a diagnosis-most frequently within the cervical lymph nodes, followed by the liver, lungs, and bones. Intraocular metastases are extremely rare. We present a case of choroidal metastasis as a first presentation of disease progression in a patient with Multiple Endocrine Neoplasia type 2A syndrome (MEN2A) who had undergone thyroidectomy 33 years earlier for medullary thyroid carcinoma...
April 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29659412/photodynamic-therapy-as-primary-treatment-for-small-choroidal-melanoma
#15
Elif B Turkoglu, Renelle Pointdujour-Lim, Arman Mashayekhi, Carol L Shields
PURPOSE: To report outcomes of photodynamic therapy (PDT) as primary treatment for small amelanotic choroidal melanoma. METHODS: Retrospective interventional case series of 12 patients with small choroidal melanoma treated with standard-fluence PDT (83 seconds; 50 J/cm) using verteporfin. OUTCOME MEASURES: Tumor regression, subretinal fluid resolution, best-corrected visual acuity, and PDT complications. RESULTS: There were 12 eyes with melanoma, demonstrating amelanotic (10 [83%]) or lightly pigmented (n = 2, 17%) appearance...
April 13, 2018: Retina
https://www.readbyqxmd.com/read/29659389/fdg-pet-ct-focal-uptake-on-an-ocular-prosthesis
#16
Alessandra Repetto, Carolina Igua, Pablo Sopena, Pilar Bello
We present a case of an unexpected focally increased radiotracer uptake in an artificial eye in an FDG-PET/CT scan that was performed on a woman with a history of choroidal melanoma. It is crucial to know the type of prosthesis used and the timing of replacement for a correct interpretation of the findings. Recently, an FDG PET/CT was proposed to monitor the vascularity of the prosthesis instead of gadolinium MRI or of Tc bone scintigraphy.
April 13, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29655645/proton-beam-irradiation-a-safe-procedure-in-post-equatorial-extraocular-extension-from-uveal-melanoma
#17
Ira Seibel, Aline I Riechardt, Katharina Erb-Eigner, Alexander Böker, Dino Cordini, Jens Heufelder, Antonia M Joussen
PURPOSE: This study was performed to show long-term outcomes concerning metastasis rates and local recurrence rates after primary proton beam therapy in uveal melanoma with posterior extraocular extension (EOE) with the main focus on optic nerve invasion. DESIGN: Retrospective case series METHODS: All patients treated with primary proton beam therapy for choroidal or ciliary body melanoma with posterior EOE between July 1998 and August 2010 were included. EOE was either detected upon sonography at primary examination or during the surgical application of tantalum clips onto the sclera...
April 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29643777/a-case-of-retinal-detachment-with-unique-optical-coherence-tomography-findings-after-gamma-knife%C3%A2-radiosurgery-treatment-for-choroidal-melanoma
#18
Daisaku Kimura, Teruyo Kida, Takaki Sato, Masanori Fukumoto, Ryohsuke Kohmoto, Shota Kojima, Hiroshi Mizuno, Hitoshi Sakaguchi, Jun Sugasawa, Tsunehiko Ikeda
Purpose: To report a case of retinal detachment with unique optical coherence tomography (OCT) findings after Gamma Knife® (GK; Elekta Instrument AB, Stockholm, Sweden) treatment for choroidal melanoma (CM). Case Report: A 48-year-old woman underwent GK therapy for CM in her right eye from the macula to the temporal side. While the tumor subsequently shrank, the patient developed radiation retinopathy, which was treated with laser photocoagulation. The tumor lesions later subsided; however, her visual acuity (VA) decreased 8 years after the initial treatment...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29625478/genetic-risk-factors-for-radiation-vasculopathy
#19
Thanos D Papakostas, Margaux A Morrison, Anne Marie Lane, Caroline Awh, Margaret M DeAngelis, Evangelos S Gragoudas, Ivana K Kim
Purpose: The purpose of this study was to perform a genome-wide scan for polymorphisms associated with risk of vision loss from radiation complications in patients treated with proton beam irradiation for choroidal melanoma. Methods: We identified a cohort of 126 patients at high risk of radiation complications due to tumor location within 2 disc diameters of the optic nerve and/or fovea who provided a blood sample to the Massachusetts Eye and Ear Uveal Melanoma Repository...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625446/quantitative-evaluation-of-vascular-microcirculation-using-contrast-enhanced-ultrasound-imaging-in-rabbit-models-of-choroidal-melanoma
#20
Min Gao, Jinhua Tang, Kun Liu, Ming Yang, Haiyun Liu
Purpose: We investigated the application of contrast-enhanced ultrasound (CEUS) to quantify vascular perfusion in two animal models of choroidal melanoma. Methods: B16F10 and choroidal melanoma cell line (OCM1) melanoma xenografts were implanted into the cyclodialysis cleft of rabbits' right eyes. Fundus photography, indocyanine green angiography (ICGA), B-mode ultrasound, and CEUS were used to examine the tumors. Standard vascular parameters of CEUS imaging were evaluated, including the area under the receiver operating characteristic curve (AUC), peak intensity (IMAX), mean transit time (mTT), rise time, and time to peak...
March 1, 2018: Investigative Ophthalmology & Visual Science
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