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Choroidal melanoma

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https://www.readbyqxmd.com/read/28730794/athens-eye-hospital-ocular-oncology-multidisciplinary-team-providing-combined-treatments-for-patients-with-choroidal-melanoma-3-years-results
#1
Anastasios Anastasakis, Panagiotis Zafeirakis, Charalampos Livir-Rallatos, Gerasimos Livir-Rallatos
No abstract text is available yet for this article.
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28730793/athens-eye-hospital-ocular-oncology-multidisciplinary-team-providing-combined-treatments-for-patients-with-choroidal-melanoma-3-years-results
#2
Anastasios Anastasakis, Panagiotis Zafeirakis, Charalampos Livir-Rallatos, Gerasimos Livir-Rallatos, Mutlu Hayran
No abstract text is available yet for this article.
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28728906/surgical-management-of-strabismus-following-choroidal-melanoma-plaque-brachytherapy
#3
Shatha H Alfreihi, Stacy L Pineles, Tara A McCannel, Angelica M Prada, Federico G Velez
PURPOSE: To characterize intraoperative findings, surgical approach, and postoperative outcomes in patients undergoing strabismus surgery following plaque brachytherapy for ocular melanoma. METHODS: The records of all patients who underwent plaque brachytherapy for choroidal melanoma between May 2007 and June 2016 were reviewed retrospectively to identify those who subsequently required strabismus surgery. RESULTS: Of the 461 patients who underwent plaque brachytherapy during the study period, 13 (2...
July 17, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28725254/interacts-interventional-radiotherapy-active-teaching-school-guidelines-for-quality-assurance-in-choroidal-melanoma-interventional-radiotherapy-brachytherapy-procedures
#4
REVIEW
Luca Tagliaferri, Monica Maria Pagliara, Luca Boldrini, Carmela Grazia Caputo, Luigi Azario, Maura Campitelli, Maria Antonietta Gambacorta, Daniela Smaniotto, Vincenzo Frascino, Francesco Deodato, Alessio Giuseppe Morganti, György Kovács, Vincenzo Valentini, Maria Antonietta Blasi
Eye plaque brachytherapy represents a safe and effective therapeutic approach for choroidal melanoma, combining clinical outcomes with an eye and visual preservation. As it represents a complex procedure, a specific quality assurance program is strongly suggested to improve patients and operators safety, and to reduce possible complications linked to surgical procedure and radiation exposure. The aim of this paper is to describe the INTERACTS (Interventional Radiotherapy Active Teaching School) guidelines for quality assurance in choroidal melanoma interventional radiotherapy (brachytherapy) used in our institution...
June 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28721444/neovascular-glaucoma-after-proton-beam-therapy-of-choroidal-melanoma-incidence-and-risk-factors
#5
Aline I Riechardt, Daniel Pilger, Dino Cordini, Ira Seibel, Enken Gundlach, Annette Hager, Antonia M Joussen
PURPOSE: To analyze the risk factors for the development of neovascular glaucoma (NVG) of patients with choroidal melanoma after proton beam therapy (PBT). METHOD: Clinical case series, retrospective study. We evaluated 629 consecutive patients receiving proton beam therapy for the treatment of a choroidal melanoma at the oncology service at Charité, Berlin and Helmholtz-Zentrum, Berlin between 05/1998 and 11/2008 regarding the development and risk factors of NVG...
July 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28719046/retinal-pigment-epithelium-adenoma-in-vitreous-fluid-cytology
#6
Sandhya John, Madelyn Lew
Ocular cytology specimens are relatively uncommon, adding to the difficulty of their evaluation by cytopathologists. While melanomas account for a majority of primary intraocular pigmented lesions, other diagnostic considerations must be included in the differential. This brief report highlights a case of a pigmented ocular lesion in a 24-year-old man and key morphologic, immunohistochemical, and clinical differences between melanoma, melanocytoma, choroidal nevus, and retinal pigment epithelium (RPE) adenoma...
July 18, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28706436/the-presence-of-kynurenine-aminotransferases-in-the-human-cornea-evidence-from-bioinformatics-analysis-of-gene-expression-and-immunohistochemical-staining
#7
Anna Matysik-Woźniak, Anselm Jünemann, Waldemar A Turski, Artur Wnorowski, Krzysztof Jóźwiak, Roman Paduch, Etsuo Okuno, Joanna Moneta-Wielgoś, Tomasz Chorągiewicz, Ryszard Maciejewski, Robert Rejdak
PURPOSE: Kynurenine aminotransferases (KATs) catalyze the synthesis of kynurenic acid (KYNA), a compound of significant biological activity. The aim of this study is to investigate the presence and distribution of KAT immunoreactivity in the healthy human cornea. METHODS: Data on gene expression in human eye structures were extracted from public microarray experiments using Genevestigator software. Immunohistochemistry was conducted using polyclonal antibodies against KAT I, II, and III on sections of eight enucleated eyes from patients with choroidal melanoma...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28704910/late-developing-metastatic-malignant-melanoma-in-the-thoracic-spine-originating-from-choroidal-melanoma
#8
Jun Kyu Hwang, Kyung Hyun Kim, Ji Sup Kim, Sung Jun Ahn, Sung Uk Kuh
A 54-year-old woman visited Gangnam Severance Hospital for left side flank pain. She had a history of total removal of malignant melanoma on the left eye ball 20 years prior. No evaluation had been performed since then. A paravertebral mass at thoracic ninth level (T9) was discovered on spinal magnetic resonance imaging, and pathology confirmed malignant melanoma. Following positron emission tomography-computed tomography, no other metastasis was discovered. After removal of the paravertebral mass, palliative chemotherapy (dacabarzine + tamoxifene) was administered in 3 cycles over 2 months...
June 2017: Korean Journal of Spine
https://www.readbyqxmd.com/read/28700778/frequent-gnaq-gna11-and-eif1ax-mutations-in-iris-melanoma
#9
Simone L Scholz, Inga Möller, Henning Reis, Daniela Süßkind, Johannes A P van de Nes, Sonia Leonardelli, Bastian Schilling, Elisabeth Livingstone, Tobias Schimming, Annette Paschen, Antje Sucker, Rajmohan Murali, Klaus-Peter Steuhl, Dirk Schadendorf, Henrike Westekemper, Klaus G Griewank
Purpose: The most common malignant intraocular tumors with a high mortality in adults are uveal melanomas. Uveal melanomas arise most frequently in the choroid or ciliary body (97%) and rarely in the iris (3%). Whereas conjunctival and posterior uveal (ciliary body and choroidal) melanomas have been studied in more detail genetically, little data exist regarding iris melanomas. Methods: In our study, we genetically analyzed 19 iris melanomas, 8 ciliary body melanomas, 3 ring melanomas, and 4 iris nevi...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28692599/cavitary-choroidal-metastasis-from-clear-cell-renal-cell-carcinoma
#10
Bernadete Ayres, Tanya McClendon, Hakan Demirci
PURPOSE: To report the clinical, funduscopic, and echographic features of a choroidal metastatic tumor from a clear cell renal cell carcinoma presenting with intralesional cavitation. CASE REPORT: An 81-year-old man with history of clear cell renal cell carcinoma presented with blurred vision. A clinical examination including standardized ultrasound was performed, which revealed a choroidal mass with cystic-like cavitation. The patient underwent brachytherapy with regression of the tumor...
July 7, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28690979/presentation-treatment-and-prognosis-of-secondary-melanoma-within-the-orbit
#11
Anna M Rose, Sophie Cowen, Channa N Jayasena, David H Verity, Geoffrey E Rose
BACKGROUND: Ocular melanoma is a rare but often deadly malignancy that arises in the uvea, conjunctiva, or orbit. Uveal melanoma is the most common type, with conjunctival melanoma being the second most frequently observed. Melanoma accounts for 5-10% of metastatic or secondary orbital malignancies, but only a minute proportion of primary orbital neoplasia. The aim of this study was to characterize the clinical presentation, treatment, and prognosis in patients presenting with melanoma metastatic to, or secondary within, the orbit...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28650890/solitary-choroidal-metastasis-from-lung-adenocarcinoma-on-fdg-pet-ct
#12
Zu-Gui Li
Solitary choroidal metastasis as an initial presentation of lung cancer is rare. A 67-year-old woman who initially presented with a 3-month history of blurred vision in the right eye was suggestive of choroidal melanoma on MRI. Preoperatively, a pulmonary mass was found on x-ray. She was referred for an FDG PET/CT imaging, which revealed a choroidal lesion with minimal FDG uptake in right eye and increased FDG activity in the known lung mass. A pathological diagnosis of metastatic lung adenocarcinoma was made after enucleation of the right eyeball...
June 24, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28647462/optical-coherence-tomography-angiography-of-macular-features-after-proton-beam-radiotherapy-for-small-choroidal-melanoma
#13
Alexandre Sellam, Florence Coscas, Livia Lumbroso-Le Rouic, Rémi Dendale, Marco Lupidi, Gabriel Coscas, Laurence Desjardins, Nathalie Cassoux
PURPOSE: To describe the macular features of patients treated with proton beam therapy for choroidal melanoma (CM), using the optical coherence tomography-angiography (OCTA). DESIGN: Retrospective case-control study. METHODS: This study included patients treated with proton beam radiotherapy (PBR) for a small CM. Only patients that had received 100% of the dose 60 GyEBR to the macular area were included in the analysis. All the patients have undergone a full ophthalmological examination including: visual acuity, OCT B-scan and OCTA...
June 21, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28611640/visual-loss-from-choroidal-melanoma-mimicking-neurological-syndromes
#14
Karim Hammamji, Ehud Reich, Amit Arora, Victoria M L Cohen, Mandeep S Sagoo
Melanoma of the eye is rare, but can mimic a range of disorders. This report highlights 2 cases of choroidal melanoma with vision loss mimicking neurological diagnoses. The first patient is a 41-year-old white male with a known history of multiple sclerosis and a previous episode of optic neuritis in the right eye, who presented with a 6-month history of decreased vision in the same eye, and occasional photopsiae. He was treated with 2 courses of oral steroids for presumed recurrent optic neuritis. After a temporary improvement in his symptoms, his vision worsened, following which he had a head MRI, which revealed a solid intraocular mass...
January 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/28599417/overexpression-of-the-anti-apoptotic-protein-bag3-in-human-choroidal-melanoma-a-case-report
#15
Tatsuya Yunoki, Yoshiaki Tabuchi, Takashi Kondo, Yoko Ishii, Atsushi Hayashi
Bcl-2-associated athanogene 3 (BAG3), a co-chaperone of heat shock protein 70 (HSP70), exerts anti-apoptotic effects in various malignant tumors. However, relationships between choroidal melanoma and BAG3 are poorly studied. This study investigated the expression of BAG3 in a case of human choroidal melanoma. Funduscopy, computed tomography, and single-photon emission computed tomography with the intravenous injection of N-isopropyl-p-[(123)I] iodoamphetamine strongly indicated choroidal melanoma in a 68-year-old woman...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28599335/-current-diagnosis-of-choroidal-nevi
#16
J Lüke, S Grisanti, A Tura
Despite the diversity of techniques for documentation and diagnostics of choroidal nevi, the differential diagnosis, especially regarding small uveal melanomas, remains difficult. In many cases, frequent controls to exclude growth or for the detection of an unchanged appearance are recommended. This article reviews-under consideration of the actual literature-different diagnostic techniques for documentation and differentiation of choroidal nevi.
June 9, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28597076/juxtapapillary-and-circumpapillary-choroidal-melanoma-globe-sparing-treatment-outcomes-with-iodine-125-notched-plaque-brachytherapy
#17
John V Hegde, Tara A McCannel, Colin A McCannel, James Lamb, Pin-Chieh Wang, Darlene Veruttipong, Robert Almanzor, D Jeffrey Demanes, Mitchell Kamrava
PURPOSE: Managing juxtapapillary and circumpapillary choroidal melanoma with brachytherapy is challenging because of technical complications with accurate plaque placement and high radiation toxicity given tumor proximity to the optic nerve. We evaluated our center's experience using ultrasound-guided, Iodine (I)-125 notched plaque brachytherapy for treating choroidal melanoma contiguous with (juxtapapillary) and at least partially surrounding the optic disc (circumpapillary). METHODS: All cases of choroidal melanoma treated with I-125 notched plaque brachytherapy at our center from September 2003-December 2013 were retrospectively reviewed...
June 9, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28596284/prognostic-biopsy-of-choroidal-melanoma-an-optimised-surgical-and-laboratory-approach
#18
Martina Angi, Helen Kalirai, Azzam Taktak, Rumana Hussain, Carl Groenewald, Bertil E Damato, Heinrich Heimann, Sarah E Coupland
BACKGROUND: Accurate survival prognostication for patients with uveal melanoma (UM) enables effective patient counselling and permits personalised systemic surveillance for the early detection of metastases and, in high-risk patients, enrolment in any trials of systemic adjuvant therapy. The aim of this work is to determine the success of prognostic UM tumour biopsy using an improved surgical approach and optimised sample handling workflow. METHODS: Patients with UM treated by primary radiotherapy between 2011 and 2013 and who underwent a prognostic biopsy with cytology, multiplex ligation-dependent probe amplification and/or microsatellite analysis were included...
June 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28579218/choroidal-nevus-or-melanoma-choroidal-neovascularisation-as-a-confounder-in-choroidal-nevus
#19
O Subira, H Brosa, D Lorenzo, J M Caminal
No abstract text is available yet for this article.
May 31, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28572063/pattern-of-local-recurrence-after-i-125-episcleral-brachytherapy-for-uveal-melanoma-in-a-spanish-referral-ocular-oncology-unit
#20
Sara Sánchez-Tabernero, Ciro García-Alvarez, Ma Fe Muñoz-Moreno, Patricia Diezhandino, Pilar Alonso-Martínez, Jesus M de Frutos-Baraja, Francisco López-Lara, Maria A Saornil
PURPOSE: To describe the time, frequency, and clinical characteristics of treatment failure after I-125 brachytherapy in patients with uveal melanoma treated and followed in a Spanish referral ocular oncology unit. DESIGN: Prospective, consecutive, interventional case series. METHODS: Patients diagnosed with uveal melanoma from 1995 to 2016 and treated with episcleral brachytherapy were included. Demographic data collection, ophthalmic evaluation, ultrasound scan, and systemic studies were performed at baseline, every six months thereafter for five years, and subsequently at annual intervals...
May 29, 2017: American Journal of Ophthalmology
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