keyword
https://read.qxmd.com/read/38508102/relapse-after-electric-barrier-induced-voluntary-abstinence-a-review
#21
REVIEW
Kenichiro Negishi, Ida Fredriksson, Jennifer M Bossert, Abraham Zangen, Yavin Shaham
Relapse to drug use during abstinence is a defining feature of addiction. To date, however, results from studies using rat relapse/reinstatement models have yet to result in FDA-approved medications for relapse prevention. To address this translational gap, we and others have developed rat models of relapse after voluntary abstinence from drug self-administration. One of these models is the electric barrier conflict model. Here, we introduce the model, and then review studies on behavioral and neuropharmacological mechanisms of cue-induced relapse and incubation of drug seeking (time-dependent increase in drug seeking during abstinence) after electric barrier-induced abstinence...
March 19, 2024: Current Opinion in Neurobiology
https://read.qxmd.com/read/38504566/histaminergic-system-and-vestibular-function-in-normal-and-pathological-conditions
#22
JOURNAL ARTICLE
Brahim Tighilet, Jessica Trico, Emna Marouane, Andreas Zwergal, Christian Chabbert
Most neurotransmitter systems are represented in the central and peripheral vestibular system and are thereby involved both in normal vestibular signal processing and the pathophysiology of vestibular disorders. However, there is a special relationship between the vestibular system and the histaminergic system. The purpose of this review is to document how the histaminergic system interferes with normal and pathological vestibular function. In particular, we will discuss neurobiological mechanisms such as neuroinflammation that involve histamine to modulate and allow restoration of balance function in the situation of a vestibular insult...
March 19, 2024: Current Neuropharmacology
https://read.qxmd.com/read/38504012/dorsal-ca3-overactivation-mediates-witnessing-stress-induced-recognition-memory-deficits-in-adolescent-male-mice
#23
JOURNAL ARTICLE
Xiao Liu, Rui Liu, Ya-Xin Sun, Hong-Li Wang, Han Wang, Ting Wang, Yu-Nu Ma, Xue-Xin Li, Qi Wang, Yun-Ai Su, Ji-Tao Li, Tian-Mei Si
Witnessing violent or traumatic events is common during childhood and adolescence and could cause detrimental effects such as increased risks of psychiatric disorders. This stressor could be modeled in adolescent laboratory animals using the chronic witnessing social defeat (CWSD) paradigm, but the behavioral consequences of CWSD in adolescent animals remain to be validated for cognitive, anxiety-like, and depression-like behaviors and, more importantly, the underlying neural mechanisms remain to be uncovered...
March 19, 2024: Neuropsychopharmacology
https://read.qxmd.com/read/38502148/viloxazine-extended-release-capsules-as-an-emerging-treatment-for-attention-deficit-hyperactivity-disorder-in-children-and-adolescents
#24
REVIEW
Vladimir Maletic, Gregory W Mattingly, Jami Earnest
INTRODUCTION: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention and/or hyperactivity and impulsivity. Viloxazine extended-release (ER) capsules (Qelbree®) is a US Food and Drug Administration-approved nonstimulant treatment option for children, adolescents, and adults with ADHD. AREAS COVERED: This review manuscript summarizes the neurobiology of ADHD and currently available treatment options before discussing viloxazine pharmacology, efficacy, safety, and tolerability data from phase II and III trials in children and adolescents (6-17 years old)...
March 19, 2024: Expert Review of Neurotherapeutics
https://read.qxmd.com/read/38500272/boltzmann-s-theorem-revisited-inaccurate-time-to-action-clocks-in-affective-disorders
#25
JOURNAL ARTICLE
Sari Goldstein Ferber, Aron Weller, Hermona Soreq
Timely goal-oriented behavior is essential for survival and is shaped by experience. In this paper, a multileveled approach was employed, ranging from the polymorphic level through thermodynamic molecular, cellular, intracellular, extracellular, non-neuronal organelles and electrophysiological waves, attesting for signal variability. By adopting Boltzmann's theorem as a thermodynamic conceptualization of brain work, we found deviations from excitation-inhibition balance and wave decoupling, leading to wider signal variability in affective disorders compared to healthy individuals...
March 18, 2024: Current Neuropharmacology
https://read.qxmd.com/read/38500267/the-effective-perospirone-augmentation-with-clonazepam-for-treatment-resistant-burning-mouth-syndrome-a-case-report
#26
Motoko Watanabe, Chihiro Takao, Chizuko Maeda, Gayatri Nayanar, Risa Tominaga, Yasuyuki Kimura, Trang Thi Huyen Tu, Takahiko Nagamine, Akira Toyofuku
Burning mouth syndrome (BMS) is characterized by burning sensations in the oral region without corresponding abnormalities and is often accompanied by uncomfortable sensations. Herein, we present cases of BMS in which the remaining uncomfortable sensations improved with perospirone augmentation with clonazepam. Case 1: A 61-year-old man complained of a burning pain in his tongue, a sensation of dryness and discomfort as if his tongue was sticking to a palatal plate. With the diagnosis of BMS, psychopharmacotherapy was initiated with amitriptyline...
March 18, 2024: Neuropsychopharmacology Reports
https://read.qxmd.com/read/38499720/dnmt3a1-regulates-hippocampus-dependent-memory-via-the-downstream-target-nrp1
#27
JOURNAL ARTICLE
Janina Kupke, Julien Klimmt, Franziska Mudlaff, Maximilian Schwab, Pavlo Lutsik, Christoph Plass, Carsten Sticht, Ana M M Oliveira
Epigenetic factors are well-established players in memory formation. Specifically, DNA methylation is necessary for the formation of long-term memory in multiple brain regions including the hippocampus. Despite the demonstrated role of DNA methyltransferases (Dnmts) in memory formation, it is unclear whether individual Dnmts have unique or redundant functions in long-term memory formation. Furthermore, the downstream processes controlled by Dnmts during memory consolidation have not been investigated. In this study, we demonstrated that Dnmt3a1, the predominant Dnmt in the adult brain, is required for long-term spatial object recognition and contextual fear memory...
March 18, 2024: Neuropsychopharmacology
https://read.qxmd.com/read/38499719/insular-cortex-subregions-have-distinct-roles-in-cued-heroin-seeking-after-extinction-learning-and-prolonged-withdrawal-in-rats
#28
JOURNAL ARTICLE
Matthew S McGregor, Caitlin V Cosme, Ryan T LaLumiere
Evidence indicates that the anterior (aIC), but not posterior (pIC), insular cortex promotes cued reinstatement of cocaine seeking after extinction in rats. It is unknown whether these subregions also regulate heroin seeking and whether such involvement depends on prior extinction learning. To address these questions, we used baclofen and muscimol (BM) to inactivate the aIC or pIC bilaterally during a seeking test after extinction or prolonged withdrawal from heroin. Male Sprague-Dawley rats in the extinction groups underwent 10+ days of heroin self-administration, followed by 6+ days of extinction sessions, and subsequent cued or heroin-primed reinstatement...
March 18, 2024: Neuropsychopharmacology
https://read.qxmd.com/read/38494338/association-between-the-early-repolarization-pattern-and-nocturnal-suicide-attempts
#29
JOURNAL ARTICLE
Hiroshi Kameyama, Kenichi Sugimoto, Fumitoshi Kodaka, Kenji Okuno, Takahiro Masaki, Kazutaka Nukariya, Masahiro Shigeta
AIM: Numerous recent reports have highlighted the association between mental disorders and electrocardiographic findings. The early repolarization pattern (ERP) on electrocardiogram has been linked with a history of suicide attempts and attention deficit hyperactivity disorder, and associations with impulsivity have also been reported. It is known that suicidal intent is more common at night. Patients who have a mental disorder and ERP may have a higher likelihood of impulsivity, potentially increasing the risk of suicide at night...
March 17, 2024: Neuropsychopharmacology Reports
https://read.qxmd.com/read/38494124/neuro-modulatory-impact-of-felodipine-against-experimentally-induced-parkinson-s-disease-possible-contribution-of-pink1-parkin-mitophagy-pathway
#30
JOURNAL ARTICLE
Hadeer O Abou-Hany, Mohamed El-Sherbiny, Sally Elshaer, Eman Said, Tarek Moustafa
Parkinson's disease (PD) is a prevalent neurodegenerative disorder, characterized by motor and psychological dysfunction. Palliative treatment and dopamine replenishment therapy are the only available therapeutic options. Calcium channel blockers (CCBs) have been reported to protect against several neurodegenerative disorders. The current study was designed to evaluate the neuroprotective impact of Felodipine (10 mg/kg, orally) as a CCB on motor and biochemical dysfunction associated with experimentally induced PD using rotenone (2...
March 15, 2024: Neuropharmacology
https://read.qxmd.com/read/38494123/resveratrol-evokes-neuroprotective-effects-and-improves-foot-stance-following-kainate-induced-excitotoxic-damage-to-the-mouse-spinal-cord
#31
JOURNAL ARTICLE
Benjamín Zylberberg, Martina Poodts, Julieta Roncoroni, M Florencia Coronel, Graciela L Mazzone
Excitotoxicity, characterized by over-activation of glutamate receptors, is a major contributor to spinal cord injury (SCI) pathophysiology, resulting in neuronal death and loss of locomotor function. In our previous in vitro studies, we showed that excitotoxicity induced by the glutamate analogue kainate (KA) leads to a significant reduction in the number of neurons, providing a model for SCI. Our current objective was to assess the neuroprotective role of resveratrol (RESV), a natural polyphenol, following KA-induced SCI...
March 15, 2024: Neuropharmacology
https://read.qxmd.com/read/38492884/ginkgolide-b-can-alleviate-spinal-glymphatic-system-dysfunction-and-provide-neuroprotection-in-pdn-rats-by-inhibiting-matrix-metalloproteinase-9
#32
JOURNAL ARTICLE
Jiang Li, Shuaiying Jia, Yuehan Song, Wenmei Xu, Jingyan Lin
The glymphatic system plays a crucial role in maintaining optimal central nervous system (CNS) function by facilitating the removal of metabolic wastes. Aquaporin-4 (AQP4) protein, predominantly located on astrocyte end-feet, is a key pathway for metabolic waste excretion. β-Dystroglycan (β-DG) can anchor AQP4 protein to the end-feet membrane of astrocytes and can be cleaved by matrix metalloproteinase (MMP)-9 protein. Studies have demonstrated that hyperglycemia upregulates MMP-9 expression in the nervous system, leading to neuropathic pain...
March 14, 2024: Neuropharmacology
https://read.qxmd.com/read/38492883/pgc-1%C3%AE-in-the-hippocampus-mediates-depressive-like-and-stress-coping-behaviours-and-regulates-excitatory-synapses-in-the-dentate-gyrus-in-mice
#33
JOURNAL ARTICLE
Yuhui Deng, Xin Liang, Yue Li, Lin Jiang, Jin Wang, Jing Tang, Jing Li, Yuhan Xie, Kai Xiao, Peilin Zhu, Yijing Guo, Yanmin Luo, Yong Tang
Decreased hippocampal synaptic plasticity is an important pathological change in stress-related mood disorders, including major depressive disorder. However, the underlying mechanism is unclear. PGC-1α, a transcriptional coactivator, is a key factor in synaptic plasticity. We investigated the relationships between changes in hippocampal PGC-1α expression and depressive-like and stress-coping behaviours, and whether they are related to hippocampal synapses. Adeno-associated virus was used to alter hippocampal PGC-1α expression in male C57BL/6 mice...
March 14, 2024: Neuropharmacology
https://read.qxmd.com/read/38490299/roles-of-mechanosensitive-ion-channel-piezo1-in-the-pathogenesis-of-brain-injury-after-experimental-intracerebral-hemorrhage
#34
JOURNAL ARTICLE
Min Qi, Ran Liu, Fan Zhang, Zhipeng Yao, Meng-Liang Zhou, Xiaochun Jiang, Shizhang Ling
Secondary brain injury after intracerebral hemorrhage (ICH) is the main cause of poor prognosis in ICH patients, but the underlying mechanisms remain less known. The involvement of Piezo1 in brain injury after ICH was studied in a mouse model of ICH. ICH was established by injecting autologous arterial blood into the basal ganglia in mice. After vehicle, Piezo1 blocker, GsMTx4, Piezo1 activator, Yoda-1, or together with mannitol (tail vein injection) was injected into the left lateral ventricle of mouse brain, Piezo1 level and the roles of Piezo1 in neuronal injury, brain edema, and neurological dysfunctions after ICH were determined by the various indicated methods...
March 13, 2024: Neuropharmacology
https://read.qxmd.com/read/38486390/armodafinil-as-a-potential-pharmacological-treatment-for-attention-deficit-hyperactivity-disorder-in-adults-a-review
#35
JOURNAL ARTICLE
Reyna Lamas-Aguilar, Araceli Diaz-Ruiz, Luz Navarro, Raúl Miranda-Ojeda, María de Los Ángeles Martínez-Cárdenas, Alfonso Mata-Bermudez, Camilo Rios
INTRODUCTION: Armodafinil is a psychostimulant that promotes alertness, and it has been shown to improve attention, memory, and fatigue in healthy adults and adults with neurodevelopmental conditions that share symptoms with Attention Deficit Hyperactivity Disorder (ADHD). It is generally well tolerated and safe, and most of the adverse events reported are considered not serious. However, the available evidence on the efficacy of armodafinil for the treatment of ADHD in adults is scarce...
March 14, 2024: Current Neuropharmacology
https://read.qxmd.com/read/38486389/a-mechanistic-review-on-protective-effects-of-mangosteen-and-its-xanthones-against-hazardous-materials-and-toxins
#36
JOURNAL ARTICLE
Roghayeh Yahyazadeh, Vafa Baradaran Rahimi, Ahmad Yahyazadeh, Vahid Reza Askari
Due to its pharmacological properties, α-Mangostin, mainly found in Garcinia mangostana (G. mangostana) L. (Mangosteen, queen of fruits), treats wounds, skin infections, and many other disorders. In fact, α-Mangostin and other xanthonoid, including β-Mangostin and γ-Mangostin, are found in G. mangostana, which have various advantages, namely neuroprotective, anti-proliferative, antinociceptive, antioxidant, pro-apoptotic, anti-obesity, anti-inflammatory, and hypoglycemic through multiple signaling mechanisms, for instance, extracellular signal-regulated kinase1/2 (ERK 1/2), mitogenactivated Protein kinase (MAPK), nuclear factor-kappa B (NF-kB), transforming growth factor beta1 (TGF-β1) and AMP-activated protein kinase (AMPK)...
March 14, 2024: Current Neuropharmacology
https://read.qxmd.com/read/38486051/in-memoriam-brian-e-leonard-phd-dsc-mria
#37
EDITORIAL
John F Cryan
No abstract text is available yet for this article.
March 14, 2024: Neuropsychopharmacology
https://read.qxmd.com/read/38484736/good-heavens-finally-a-landslide-analysis-of-basal-ganglia-circuitry-in-teleosts
#38
JOURNAL ARTICLE
Mario F Wullimann
Tanimoto et al.1 report essential information on teleostean basal ganglia circuitry. This analysis opens gateways into studying neurophysiology, neuropharmacology, and behavior in zebrafish, guided by this complex functional neural system common to all vertebrates.
March 8, 2024: Cell Reports
https://read.qxmd.com/read/38483732/perioperative-levels-of-il8-and-il18-but-not-il6-are-associated-with-nucleus-basalis-magnocellularis-atrophy-three-months-after-surgery
#39
JOURNAL ARTICLE
Maria Heinrich, Claudia Spies, Friedrich Borchers, Insa Feinkohl, Tobias Pischon, Arjen J C Slooter, Clarissa von Haefen, Norman Zacharias, Georg Winterer, Florian Lammers-Lietz
Past studies have observed that brain atrophy may accelerate after surgical procedures. Furthermore, an association of systemic inflammation with neurodegeneration has been described. We hypothesize that postoperative interleukin (IL) levels in circulation as well as the perioperative change in interleukin levels are associated with increased postoperative atrophy in the Nucleus basalis magnocellularis (of Meynert, NBM) which is the major source of cortical acetylcholine. We analyzed data from the BioCog cohort which included patients ≥ 65 years presenting for elective major surgery (≥ 60min)...
March 14, 2024: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/38480911/clinical-decision-support-for-bipolar-depression-using-large-language-models
#40
JOURNAL ARTICLE
Roy H Perlis, Joseph F Goldberg, Michael J Ostacher, Christopher D Schneck
Management of depressive episodes in bipolar disorder remains challenging for clinicians despite the availability of treatment guidelines. In other contexts, large language models have yielded promising results for supporting clinical decisionmaking. We developed 50 sets of clinical vignettes reflecting bipolar depression and presented them to experts in bipolar disorder, who were asked to identify 5 optimal next-step pharmacotherapies and 5 poor or contraindicated choices. The same vignettes were then presented to a large language model (GPT4-turbo; gpt-4-1106-preview), with or without augmentation by prompting with recent bipolar treatment guidelines, and asked to identify the optimal next-step pharmacotherapy...
March 13, 2024: Neuropsychopharmacology
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