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Neuropharmacology

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https://www.readbyqxmd.com/read/29784925/acrylamide-acute-neurotoxicity-in-adult-zebrafish
#1
Melissa Faria, Tamar Ziv, Cristian Gómez-Canela, Shani Ben-Lulu, Eva Prats, Karen Adriana Novoa-Luna, Arie Admon, Benjamin Piña, Romà Tauler, Leobardo Manuel Gómez-Oliván, Demetrio Raldúa
Acute exposure to acrylamide (ACR), a type-2 alkene, may lead to a ataxia, skeletal muscles weakness and numbness of the extremities in human and laboratory animals. In the present manuscript, ACR acute neurotoxicity has been characterized in adult zebrafish, a vertebrate model increasingly used in human neuropharmacology and toxicology research. At behavioral level, ACR-treated animals exhibited "depression-like" phenotype comorbid with anxiety behavior. At transcriptional level, ACR induced down-regulation of regeneration-associated genes and up-regulation of oligodendrocytes and reactive astrocytes markers, altering also the expression of genes involved in the presynaptic vesicle cycling...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29782640/drug-gut-microbiota-interactions-implications-for-neuropharmacology
#2
REVIEW
Jacinta Walsh, Brendan T Griffin, Gerard Clarke, Niall P Hyland
The fate and activity of drugs are frequently dictated not only by the host per se but also by the microorganisms present in the gastrointestinal tract. The gut microbiome is known to, both directly and indirectly, affect drug metabolism. More evidence now hints at the impact that drugs can have on the function and composition of the gut microbiome. Both microbiota-mediated alterations in drug metabolism and drug-mediated alterations in the gut microbiome can have beneficial or detrimental effects on the host...
May 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29767995/structure-activity-relationships-and-therapeutic-potentials-of-5-ht7-receptor-ligands-an-update
#3
Maria N Modica, Enza Lacivita, Sebastiano Intagliata, Loredana Salerno, Giuseppe Romeo, Valeria Pittala, Marcello Leopoldo
Serotonin 5-HT7 receptor (5-HT7R) has been the subject of intense research efforts because of its presence in brain areas such as hippocampus, hypothalamus, and cortex. Preclinical data link the 5-HT7R to a variety of central nervous system processes such as regulation of circadian rhythms, mood, cognitions, pain processing, and mechanisms of addiction. 5-HT7R blockade has antidepressant effects and may ameliorate cognitive deficits associated with schizophrenia. 5-HT7R has been recently shown to modulate neuronal morphology, excitability, and plasticity, thus contributing to shape brain networks during development and to remodel neuronal wiring in the mature brain...
May 16, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29755370/effects-of-ethanol-on-sensory-inputs-to-the-medial-giant-interneurons-of-crayfish
#4
Matthew E Swierzbinski, Jens Herberholz
Crayfish are capable of two rapid, escape reflexes that are mediated by two pairs of giant interneurons, the lateral giants (LG) and the medial giants (MG), which respond to threats presented to the abdomen or head and thorax, respectively. The LG has been the focus of study for many decades and the role of GABAergic inhibition on the escape circuit is well-described. More recently, we demonstrated that the LG circuit is sensitive to the acute effects of ethanol and this sensitivity is likely mediated by interactions between ethanol and the GABAergic system...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29743967/neuropharmacological-potential-and-delivery-prospects-of-thymoquinone-for-neurological-disorders
#5
REVIEW
Md Jakaria, Duk-Yeon Cho, Md Ezazul Haque, Govindarajan Karthivashan, In-Su Kim, Palanivel Ganesan, Dong-Kug Choi
Thymoquinone (TQ) is an active ingredient isolated from Nigella sativa and has various pharmacological activities, such as protection against oxidative stress, inflammation, and infections. In addition, it might be a potential neuropharmacological agent because it exhibits versatile potential for attenuating neurological impairments. It features greater beneficial effects in toxin-induced neuroinflammation and neurotoxicity. In various models of neurological disorders, it demonstrates emergent functions, including safeguarding various neurodegenerative diseases and other neurological diseases, such as stroke, schizophrenia, and epilepsy...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29743859/recent-updates-on-neuropharmacological-effects-of-luteolin
#6
Gaurav Gupta, Juhi Tiwari, Rajiv Dahiya, Rakesh Kumar Sharma, Anurag Mishra, Kamal Dua
No abstract text is available yet for this article.
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29743852/n1-benzenesulfonyl-2-pyrazoline-hybrids-in-neurological-disorders-syntheses-biological-screening-and-computational-studies
#7
Avinash C Tripathi, Savita Upadhyay, Sarvesh Paliwal, Shailendra K Saraf
A novel series of 1,3,5-trisubstituted-2-pyrazolines (5a-5t ) was prepared via Claisen Schmidt condensation, followed by heterocyclization with hydrazine hydrate, substitution of N1 hydrogen of 2-pyrazoline nucleus with 4-chlorobenzenesulfonylchloride, applying conventional and green chemistry approaches. Among the two, microwave assisted organic synthesis (MAOS) emerged as a better synthetic tool in terms of faster reaction rate and high yield. Various physicochemical and spectral studies were conducted to characterize the synthesized derivatives including- IR, Mass, 1 H-NMR, 13 C-NMR and elemental analysis...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29740317/-moringa-oleifera-seed-extract-alleviates-scopolamine-induced-learning-and-memory-impairment-in-mice
#8
Juan Zhou, Wu-Shuang Yang, Da-Qin Suo, Ying Li, Lu Peng, Lan-Xi Xu, Kai-Yue Zeng, Tong Ren, Ying Wang, Yu Zhou, Yun Zhao, Li-Chao Yang, Xin Jin
The extract of Moringa oleifera seeds has been shown to possess various pharmacological properties. In the present study, we assessed the neuropharmacological effects of 70% ethanolic M. oleifera seed extract (MSE) on cognitive impairment caused by scopolamine injection in mice using the passive avoidance and Morris water maze (MWM) tests. MSE (250 or 500 mg/kg) was administered to mice by oral gavage for 7 or 14 days, and cognitive impairment was induced by intraperitoneal injection of scopolamine (4 mg/kg) for 1 or 6 days...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29706888/antinociceptive-and-anxiolytic-and-sedative-effects-of-methanol-extract-of-anisomeles-indica-an-experimental-assessment-in-mice-and-computer-aided-models
#9
Md Josim Uddin, A S M Ali Reza, Md Abdullah-Al-Mamun, Mohammad S H Kabir, Mst Samima Nasrin, Sharmin Akhter, Md Saiful Islam Arman, Md Atiar Rahman
Anisomeles indica (L.) kuntze is widely used in folk medicine against various disorders including allergy, sores, inflammation, and fever. This research investigated the antinociceptive, anxiolytic and sedative effects of A. indica methanol extract. The antinociceptive activity was assessed with the acetic acid-induced writhing test and formalin-induced flicking test while sedative effects with open field and hole cross tests and anxiolytic effects with elevated plus maze (EPM) and thiopental-induced sleeping time tests were assayed...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29692706/the-relationship-between-dopamine-neurotransmitter-dynamics-and-the-blood-oxygen-level-dependent-bold-signal-a-review-of-pharmacological-functional-magnetic-resonance-imaging
#10
REVIEW
Tyler J Bruinsma, Vidur V Sarma, Yoonbae Oh, Dong Pyo Jang, Su-Youne Chang, Greg A Worrell, Val J Lowe, Hang Joon Jo, Hoon-Ki Min
Functional magnetic resonance imaging (fMRI) is widely used in investigations of normal cognition and brain disease and in various clinical applications. Pharmacological fMRI (pharma-fMRI) is a relatively new application, which is being used to elucidate the effects and mechanisms of pharmacological modulation of brain activity. Characterizing the effects of neuropharmacological agents on regional brain activity using fMRI is challenging because drugs modulate neuronal function in a wide variety of ways, including through receptor agonist, antagonist, and neurotransmitter reuptake blocker events...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29677541/tert-butyl-4-1-phenyl-1h-pyrazol-4-yl-methyl-piperazine-1-carboxylate-lqfm104-new-piperazine-derivative-with-antianxiety-and-antidepressant-like-effects-putative-role-of-serotonergic-system
#11
Dayane Moreira da Silva, Germán Sanz, Boniek Gontijo Vaz, Flávio Silva de Carvalho, Luciano Morais Lião, Danillo Ramos de Oliveira, Lorrane Kelle da Silva Moreira, Carina Sofia Cardoso, Adriane Ferreira de Brito, Daiany Priscilla Bueno da Silva, Fabio Fagundes da Rocha, Ianca Gontijo Cavalcante Santana, Pablinny Moreira Galdino, Elson Alves Costa, Ricardo Menegatti
The piperazine derivatives correspond to an extensive chemical class of compounds with numerous neuropharmacological activities, including antidepressant (e.g., nefazodone, trazodone) and anxiolytic (e.g., buspirone) properties. Therefore, aiming to identify a new antidepressant and antianxiety lead-compound, our group designed, synthesized, and investigated the effects of a new piperazine compound, namely, LQFM104, on the behavior of mice. Male albino Swiss mice were treated with LQFM104 prior to predictive behavioral tests as open field (OFT), elevated plus maze (EPM), forced swimming (FST), and tail suspension tests (TST)...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29658840/neuropharmacological-and-molecular-docking-studies-of-xanthones-from-swertia-corymbosa
#12
Ganesan Mahendran, Ramachandran Vijayan
Anxiety represents a public health problem consistently found to be the most prevalent class of mental disorders among people of all ages. Xanthones possess many biological properties, including neuroprotective, antioxidant or antidepressant-like. In this study, we aimed to investigate anxiolytic-like antidepressant and anticonvulsant properties of isolated xanthones from Swertia corymbosa. We evaluated anxiolytic-like activity of compounds 1-3 in the mouse elevated plus maze (EPM) and open field test (OF)...
April 2018: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/29627297/neuropharmacological-effects-of-essential-oil-from-the-leaves-of-croton-conduplicatus-kunth-and-possible-mechanisms-of-action-involved
#13
Raimundo Gonçalves de Oliveira Júnior, Christiane Adrielly Alves Ferraz, Juliane Cabral Silva, Roxana Braga de Andrade Teles, Mariana Gama E Silva, Tâmara Coimbra Diniz, Uiliane Soares Dos Santos, Ana Valéria Vieira de Souza, Carlos Eduardo Pereira Nunes, Marcos José Salvador, Vitor Prates Lorenzo, Lucindo José Quintans Junior, Jackson Roberto Guedes da Silva Almeida
ETHNOPHARMACOLOGICAL RELEVANCE: Croton conduplicatus Kunth (Euphorbiaceae) is a Brazilian aromatic medicinal plant, widely known as "quebra-faca". In folk medicine, its leaves and stem-barks are used as a natural analgesic for the treatment of headaches. AIM OF THE STUDY: In this study, we describe for the first time the neuropharmacological potential of the essential oil obtained from the leaves of Croton conduplicatus (EO) in experimental models of pain, anxiety and insomnia...
April 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29604984/neuropharmacology
#14
Alan Winston, Hadi Manji
With virologically suppressive antiretroviral therapy, immune system recovery is now achievable for persons living with HIV (PLWH). This immune recovery is associated with dramatic reductions in acquired immune deficiency syndrome (AIDS) defining illnesses including HIV dementia. However, milder form of cognitive disturbances are widely reported in PLWH despite effective antiretroviral therapy. The underlying pathogenic mechanisms of these cognitive disturbances remain elusive, with many potential pathogenic mechanisms including residual brain damage prior to the initiation of antiretroviral therapy and neuroinflammation and ongoing immune system disturbances despite antiretroviral therapy...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29599720/ethnopharmacology-a-bibliometric-analysis-of-a-field-of-research-meandering-between-medicine-and-food-science
#15
Andy Wai Kan Yeung, Michael Heinrich, Atanas G Atanasov
Background: The research into bioactive natural products of medicinal plants has a long tradition, but ethnopharmacology as a well-defined field of research has a relatively short history, only dating back 50 years. Aims: With the fast development of this field and its global importance especially in the fast developing economies of Asia it is timely to assess the most influential articles (as measured by citations) and to identify important drivers and research trends in this field. Methods: Scopus was searched to identify relevant articles which were assessed by all three authors...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29568270/unifying-theories-of-psychedelic-drug-effects
#16
REVIEW
Link R Swanson
How do psychedelic drugs produce their characteristic range of acute effects in perception, emotion, cognition, and sense of self? How do these effects relate to the clinical efficacy of psychedelic-assisted therapies? Efforts to understand psychedelic phenomena date back more than a century in Western science. In this article I review theories of psychedelic drug effects and highlight key concepts which have endured over the last 125 years of psychedelic science. First, I describe the subjective phenomenology of acute psychedelic effects using the best available data...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29555857/role-of-the-5-ht-2a-receptor-in-self-and-other-initiated-social-interaction-in-lysergic-acid-diethylamide-induced-states-a-pharmacological-fmri-study
#17
Katrin H Preller, Leonhard Schilbach, Thomas Pokorny, Jan Flemming, Erich Seifritz, Franz X Vollenweider
Distortions of self-experience are critical symptoms of psychiatric disorders and have detrimental effects on social interactions. In light of the immense need for improved and targeted interventions for social impairments, it is important to better understand the neurochemical substrates of social interaction abilities. We therefore investigated the pharmacological and neural correlates of self- and other-initiated social interaction. In a double-blind, randomized, counterbalanced, crossover study 24 healthy human participants (18 males and 6 females) received either (1) placebo + placebo, (2) placebo + lysergic acid diethylamide (LSD; 100 μg, p...
April 4, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29532180/serotonergic-psychedelics-experimental-approaches-for-assessing-mechanisms-of-action
#18
Clinton E Canal
Recent, well-controlled - albeit small-scale - clinical trials show that serotonergic psychedelics, including psilocybin and lysergic acid diethylamide, possess great promise for treating psychiatric disorders, including treatment-resistant depression. Additionally, fresh results from a deluge of clinical neuroimaging studies are unveiling the dynamic effects of serotonergic psychedelics on functional activity within, and connectivity across, discrete neural systems. These observations have led to testable hypotheses regarding neural processing mechanisms that contribute to psychedelic effects and therapeutic benefits...
March 13, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29530454/neuropharmacological-evaluation-on-four-traditional-herbs-used-as-nervine-tonic-and-commonly-available-as-shankhpushpi-in-india
#19
Neeraj K Sethiya, Alok Nahata, Pawan Kumar Singh, S H Mishra
OBJECTIVE: The present study was undertaken to evaluate the neuropharmacological effect of four herbs commonly identified as source of Shankhpushpi. BACKGROUND: Shankhpushpi is an Ayurvedic drug, widely used for its actions on the central nervous system, especially to improve intellect and boost memory. Four botanicals viz. Canscora decussata Schult. (CD), Clitorea ternatea Linn. (CT), Convolvulus pluricaulis Choisy. (CP) and Evolvulus alsinoides Linn. (EA) are considered as sources of Shankhpushpi by Indian practitioners on the basis of their morphological descriptions given in ancient texts...
March 9, 2018: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29521237/closed-loop-neuropharmacology-for-epilepsy-distant-dream-or-future-reality
#20
Irene Aicua-Rapun, Pascal Andre, Jan Novy
Epilepsy is considered the most frequent severe neurological condition but most patients treated with medication become seizure free. The management of treatment however is highly empirical, mainly relying on observation. A closed-loop therapy for epilepsy would be very valuable for more efficient treatment regimens. Here we discuss monitoring treatment (therapeutic drug monitoring) and the potential developments in this field, as well as providing a review of potential biomarkers that could be used to monitor the disease activity...
March 8, 2018: Current Neuropharmacology
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