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Comparative oncology

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https://www.readbyqxmd.com/read/29220380/hexokinase-2-hk2-the-tumor-promoter-in-glioma-is-downregulated-by-mir-218-bmi1-pathway
#1
Hui Liu, Nan Liu, Yingduan Cheng, Weilin Jin, Pengxing Zhang, Xin Wang, Hongwei Yang, Xiaoshan Xu, Zhen Wang, Yanyang Tu
In cancer, glycolysis driving enzymes and their regulating microRNAs are one of the key focus of oncology research lately. The glycolytic enzyme hexokinase 2 (HK2) is crucial for the Warburg effect in human glioma, the most common malignant brain tumor. In the present study, we studied the tumorigenic role of HK2 in glioma, and clarified the mechanism of miR-218 induced HK2 regulation in glioma development. The HK2 expression in patient derived glioma and non neoplastic brain tissue was quantified. The HK2 silenced U87 and U251 cell lines were assessed for their proliferation, migration and invasive potential in vitro, while the tumor forming potential of U87 cells was evaluated in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/29218670/systematic-review-of-robotic-low-anterior-resection-for-rectal-cancer
#2
Christoph Holmer, Martin E Kreis
BACKGROUND: Potential advantages of robotic surgery, such as 3-dimensional high-definition vision, wrist-like movements of instruments, stable camera holding, motion filter for tremor-free surgery, and improved ergonomics, may provide better clinical, oncological, and functional outcomes in rectal cancer surgery, as suggested in many comparative studies. However, there has not been a systematic review specific to LAR/TME for rectal cancer that includes both robotic versus laparoscopic and robotic versus open comparative studies...
December 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29218610/feasibility-of-whole-body-diffusion-weighted-mri-for-detection-of-primary-tumour-nodal-and-distant-metastases-in-women-with-cancer-during-pregnancy-a-pilot-study
#3
Sileny N Han, Frédéric Amant, Katrijn Michielsen, Frederik De Keyzer, Steffen Fieuws, Kristel Van Calsteren, Raphaëla C Dresen, Mina Mhallem Gziri, Vincent Vandecaveye
OBJECTIVES: To evaluate the feasibility of whole-body diffusion-weighted MRI (WB-DWI/MRI) for detecting primary tumour, nodal and distant metastases in pregnant women with cancer. METHODS: Twenty pregnant patients underwent WB-DWI/MRI in additional to conventional imaging. Reproducibility of WB-DWI/MRI between two readers was evaluated using Cohen's κ statistics and accuracy was compared to conventional imaging for assessing primary tumour site, nodal and visceral metastases...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29218255/oncology-section-edge-task-force-on-urogenital-cancer-a-systematic-review-of-clinical-measures-for-incontinence
#4
Alicia Jeffrey, Shana E Harrington, Alexandra Hill, Amanda Roscow, Meryl Alappattu
Background: Compared to the general population, women and men with urogenital and colorectal cancer experience higher rates of urinary and fecal incontinence. Although a variety of measures exist to assess these areas, currently, there are no guidelines recommending which outcomes rehabilitation professionals should administer to examine these impairments in those with cancer. Purpose: To identify outcome measures for assessing urinary and fecal incontinence and evaluate their psychometric data and applicability to the cancer population...
July 2017: Rehabilitation Oncology
https://www.readbyqxmd.com/read/29217729/bone-marrow-solid-core-biopsy-needle-a-critical-assessment-of-the-utility-benefits-and-limitations-of-the-instruments-employed-in-current-day-haematology-and-oncology
#5
REVIEW
Anwarul Islam
The optimal clinical evaluation of the bone marrow requires an examination of air-dried and well-stained films of the aspirated tissue along with a histopathological evaluation of adequately processed and properly stained core biopsy specimens. A bone marrow evaluation can be essential in establishing a diagnosis, determining the efficacy of treatment in haematological disorders and to monitor haematological status of patients following bone marrow/stem cell transplantation. It is also an essential component of the staging process for newly diagnosed malignancies...
December 7, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29216650/-have-multimodal-and-perioperative-therapeutic-strategies-changed-the-survival-after-oncological-oesophageal-surgery-in-the-last-two-decades-a-retrospective-cohort-analysis-over-23-years
#6
Philipp Lingohr, Julia Zender, Cornelius van Beekum, Jonas Dohmen, Hanno Matthaei, Nico Schaefer, Jörg C Kalff, Tim Oliver Vilz
Background Esophageal malignoma is among the most frequent causes for cancer-related deaths. The only definite curative therapy is esophagectomy embedded in various multimodal treatment regimens. The aim of this study was to evaluate long-term development after esophageal surgery in the last two decades in order to observe possible trends and their influence on short, medium and long term survival. Patients and Methods Cases of 301 patients who underwent esophagectomy between 1989 and 2012 were analysed retrospectively...
December 7, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29215819/prevalence-of-malnutrition-in-hospitalized-patients-a-multicenter-cross-sectional-study
#7
Min Chang Kang, Ji Hoon Kim, Seung Wan Ryu, Jae Young Moon, Je Hoon Park, Jong Kyung Park, Jong Hoon Park, Hyun Wook Baik, Jeong Meen Seo, Myoung Won Son, Geun Am Song, Dong Woo Shin, Yeon Myung Shin, Hong Yup Ahn, Han Kwang Yang, Hee Chul Yu, Ik Jin Yun, Jae Gil Lee, Jae Myeong Lee, Jung Hwa Lee, Tae Hee Lee, Haejun Yim, Hyun Jeong Jeon, Kyuwhan Jung, Mi Ran Jung, Chi Young Jeong, Hee Sook Lim, Suk Kyung Hong
BACKGROUND: Malnutrition is associated with many adverse clinical outcomes. The present study aimed to identify the prevalence of malnutrition in hospitalized patients in Korea, evaluate the association between malnutrition and clinical outcomes, and ascertain the risk factors of malnutrition. METHODS: A multicenter cross-sectional study was performed with 300 patients recruited from among the patients admitted in 25 hospitals on January 6, 2014. Nutritional status was assessed by using the Subjective Global Assessment (SGA)...
January 8, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29214343/correction-to-surgical-and-oncological-outcomes-after-complete-mesocolic-excision-in-right-sided-colon-cancer-compared-with-conventional-surgery-a-retrospective-single-institution-study
#8
Tommaso Zurleni, Alberto Cassiano, Elson Gjoni, Andrea Ballabio, Giovanni Serio, Luca Marzoli, Francesco Zurleni
The publisher regrets that some errors were introduced during the production process. The errors are now presented correctly in this article.
December 7, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29213299/cervical-cancer-patients-presentation-and-survival-in-the-only-oncology-referral-hospital-ethiopia-a-retrospective-cohort-study
#9
Muluken Gizaw, Adamu Addissie, Sefonias Getachew, Wondimu Ayele, Israel Mitiku, Ulrike Moelle, Tigist Yusuf, Mathias Begoihn, Mathewos Assefa, Ahmedin Jemal, Eva Johanna Kantelhardt
Background: Women infected with Human Immune Deficiency Virus (HIV) are assumed to be at higher risk of developing Cervical Cancer (CC). This is due to a rapid progression of pre-invasive to invasive lesions. However, evidences suggest, due to the availability of antiretroviral therapy (ART) and care services; an improved survival and treatment outcome of CC patients (CCPs) with HIV infection is expected. Objective: The aim of this study is to examine the clinical characteristics and survival of of CCPs registered at the radiotherapy center of Tikur Anbessa Specialized Hospital (TASH), Addis Ababa University, Ethiopia...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29212179/impact-of-cavitron-ultrasonic-surgical-aspirator-cusa-and-bipolar-radiofrequency-device-habib-4x-based-hepatectomy-for-hepatocellular-carcinoma-on-tumour-recurrence-and-disease-free-survival
#10
Kai-Wen Huang, Po-Huang Lee, Tomokazu Kusano, Isabella Reccia, Kumar Jayant, Nagy Habib
Background: The aim of this study was to evaluate the oncological outcomes of hepatocellular carcinoma patients undergoing liver resection using cavitron ultrasonic surgical aspirator (CUSA) or radiofrequency (RF) based device Habib-4X.
. Study Design: We prospectively analyzed the data of 280 patients who underwent liver resection for hepatocellular carcinoma at our institution from 2010-2012 with follow up till August 2016. The CUSA was used in the 163 patients whilst Habib-4X in 117 patients...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211407/long-term-results-of-the-implantation-of-the-ams-800-artificial-sphincter-for-post-prostatectomy-incontinence-a-single-center-experience
#11
Carlos Alberto Ricetto Sacomani, Stênio de Cássio Zequi, Walter Henriques da Costa, Bruno Santos Benigno, Rodrigo Sousa Madeira Campos, Wilson Bachega, Gustavo Cardoso Guimarães
OBJECTIVES: Report the long-term outcomes of the AMS 800 artificial sphincer (AS) for the treatment post-prostatectomy incontinence (PPI) in a single center in Brazil. MATERIALS AND METHODS: Clinical data from patients who underwent the procedure were retrieved from the medical records of individuals with more than 1 year of follow-up from May 2001 to January 2016. Continence status (number of pads that was used), complications (erosion or extrusion, urethral atrophy, and infection), malfunctions, and need for secondary implantation were evaluated...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29211298/prognostic-relevance-of-early-radiologic-response-to-induction-chemotherapy-in-pediatric-rhabdomyosarcoma-a-report-from-the-international-society-of-pediatric-oncology-malignant-mesenchymal-tumor-95-study
#12
Bas Vaarwerk, Johanna H van der Lee, Willemijn B Breunis, Daniel Orbach, Julia C Chisholm, Nathalie Cozic, Meriel Jenney, Rick R van Rijn, Kieran McHugh, Soledad Gallego, Heidi Glosli, Christine Devalck, Mark N Gaze, Anna Kelsey, Christophe Bergeron, Michael C G Stevens, Odile Oberlin, Veronique Minard-Colin, Johannes H M Merks
BACKGROUND: Early response to induction chemotherapy is used in current European guidelines to evaluate the efficacy of chemotherapy and subsequently to adapt treatment in pediatric patients with rhabdomyosarcoma (RMS). However, existing literature on the prognostic value of early radiologic response on survival is contradictory; here the prognostic value is analyzed with data from the International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumor 95 (MMT-95) study. METHODS: This study examined 432 Intergroup Rhabdomyosarcoma Study Grouping III (macroscopic residue) patients enrolled in the SIOP MMT-95 study with a response assessment after 3 courses of chemotherapy (a 2-dimensional assessment)...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29209832/minimally-invasive-esophagectomy-a-propensity-score-matched-analysis-of-semiprone-versus-prone-position
#13
Maarten F J Seesing, Lucas Goense, Jelle P Ruurda, Misha D P Luyer, Grard A P Nieuwenhuijzen, Richard van Hillegersberg
BACKGROUND: The preferred surgical approach for esophageal cancer is a minimally invasive transthoracic esophagectomy with a two-field lymph node dissection. The thoracoscopic phase may be performed either in prone- or in left lateral decubitus (LLD) position. Prone positioning has been associated with better pulmonary outcomes compared to LLD positioning; however, conversion to a classic thoracotomy is more difficult. The semiprone position has been proposed as an alternative approach...
December 5, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29209529/patient-reported-pain-severity-pain-interference-and-health-status-in-hr-her2-advanced-metastatic-breast-cancer
#14
Robert Wood, Debanjali Mitra, Jonathan de Courcy, Shrividya Iyer
Introduction: Patient-reported pain severity and related impact in advanced/metastatic breast cancer (ABC/MBC) are not well documented. The objective of this study was to assess pain and general health status in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) ABC/MBC. Methods: Data were collected in the USA and Europe in a real-world, cross-sectional study. Patients were recruited at oncology practices and completed validated questionnaires; pain severity and interference were assessed using the Brief Pain Inventory (BPI) and general health status using the EuroQoL-5D (EQ-5D-3L)...
2017: ESMO Open
https://www.readbyqxmd.com/read/29208673/biomarkers-of-primary-resistance-to-trastuzumab-in-her2-positive-metastatic-gastric-cancer-patients-the-amnesia-case-control-study
#15
Filippo Pietrantonio, Giovanni Fucà, Federica Morano, Annunziata Gloghini, Simona Corso, Giuseppe Aprile, Federica Perrone, Ferdinando De Vita, Elena Tamborini, Gianluca Tomasello, Ambra V Gualeni, Elena Ongaro, Adele Busico, Elisa Giommoni, Chiara C Volpi, Maria Maddalena Laterza, Salvatore Corallo, Michele Prisciandaro, Maria Antista, Alessandro Pellegrinelli, Lorenzo Castagnoli, Serenella Maria Pupa, Giancarlo Pruneri, Filippo G De Braud, Silvia Giordano, Chiara Cremolini, Maria Di Bartolomeo
PURPOSE: Refining the selection of HER2 positive metastatic gastric cancer patients candidates for trastuzumab is a challenge of precision oncology. Preclinical studies have suggested several genomic mechanisms of primary resistance, leading to activation of tyrosine kinase receptors other than HER2 or downstream signaling pathways. EXPERIMENTAL DESIGN: We carried out this multicenter, prospective, case-control study to demonstrate the negative predictive impact of a panel of candidate genomic alterations (AMNESIA panel), including EGFR/MET/KRAS/PI3K/PTEN mutations and EGFR/MET/KRAS amplifications...
December 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29206892/progestin-associated-shift-of-meningioma-mutational-landscape
#16
M Peyre, S Gaillard, C de Marcellus, M Giry, F Bielle, C Villa, A L Boch, H Loiseau, B Baussart, L Cazabat, M L Raffin-Sanson, M Sanson, M Kalamarides
Background: Meningiomas are the most common primary tumor of the central nervous system. The relationship between meningioma and progestins is frequently mentioned but has not been elucidated. Patients and methods: We identified 40 female patients operated for a meningioma after long-term progestin therapy and performed targeted next generation sequencing in order to decipher the mutational landscape of hormone-related meningiomas. A published cohort of 530 meningiomas in women was used as a reference population...
November 30, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29206790/aspirin-for-prophylaxis-against-venous-thromboembolism-after-orthopaedic-oncologic-surgery
#17
Gregory M Mendez, Yash M Patel, Daniel A Ricketti, John P Gaughan, Richard D Lackman, Tae Won B Kim
BACKGROUND: Patients who undergo orthopaedic oncologic surgical procedures are at increased risk of developing a venous thromboembolism (VTE). Guidelines from surgical societies are shifting to include aspirin as a postoperative VTE prophylactic agent. The purpose of this study was to review our experience using aspirin as postoperative VTE prophylaxis for orthopaedic oncologic surgical procedures. METHODS: This study was a retrospective review of patients diagnosed with a primary malignant soft-tissue or bone tumor or metastatic carcinoma...
December 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29205758/transanal-endoscopic-microsurgery-a-new-zealand-experience
#18
Ian Bloomfield, Roelof Van Dalen, Simione Lolohea, Linus Wu
BACKGROUND: Transanal endoscopic microsurgery (TEMS) is a proven alternative therapy to either radical surgery or endoscopic mucosal resection for rectal neoplasms. It has proven benefits with lower morbidity and mortality compared with total mesorectal excision, and a lower local recurrence rate when compared to endoscopic mucosal techniques. METHODS: A retrospective data collection of TEMS procedures performed through Waikato District Health Board, New Zealand, from 2010 to 2015 was conducted...
December 3, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29205358/prognostic-impact-of-postoperative-pulmonary-complications-following-salvage-esophagectomy-after-definitive-chemoradiotherapy
#19
Masaru Hayami, Masayuki Watanabe, Naoki Ishizuka, Shinji Mine, Yu Imamura, Akihiko Okamura, Takanori Kurogochi, Kotaro Yamashita
BACKGROUND: Postoperative complications after esophagectomy for esophageal cancer have a negative effect on patients' survival. Although postoperative complications are more frequently observed after salvage esophagectomy than after planned esophagectomy, the effects of postoperative complications on long-term oncologic outcomes after salvage esophagectomy remain unclear. METHODS: This retrospective study of 70 esophageal cancer patients after definitive chemoradiotherapy (dCRT) compared long-term outcomes between those with and without complications...
December 4, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29205351/oncologic-effects-of-preoperative-biliary-drainage-in-resectable-hilar-cholangiocarcinoma-percutaneous-biliary-drainage-has-no-adverse-effects-on-survival
#20
Xu-Feng Zhang, Eliza W Beal, Katiuscha Merath, Cecilia G Ethun, Ahmed Salem, Sharon M Weber, Thuy Tran, George Poultsides, Andre Y Son, Ioannis Hatzaras, Linda Jin, Ryan C Fields, Matthew Weiss, Charles Scoggins, Robert C G Martin, Chelsea A Isom, Kamron Idrees, Harveshp D Mogal, Perry Shen, Shishir K Maithel, Carl R Schmidt, Timothy M Pawlik
BACKGROUND AND OBJECTIVES: The objective of the current study was to define long-term survival of patients with resectable hilar cholangiocarcinoma (HCCA) after preoperative percutaneous transhepatic biliary drainage (PTBD) versus endoscopic biliary drainage (EBD). METHODS: Between 2000 and 2014, 240 patients who underwent curative-intent resection for HCCA were identified at 10 major hepatobiliary centers. Postoperative morbidity and mortality, as well as disease-specific survival (DSS) and recurrence-free survival (RFS) were analyzed among patients...
December 4, 2017: Journal of Surgical Oncology
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