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thyroid incidentaloma

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https://www.readbyqxmd.com/read/27758132/a-novel-thyroid-hormone-receptor-beta-gene-mutation-g251v-in-a-thai-patient-with-resistance-to-thyroid-hormone-coexisting-with-pituitary-incidentaloma
#1
Chutintorn Sriphrapradang, Panudda Srichomkwun, Samuel Refetoff, Sunee Mamanasiri
We report a patient with resistance to thyroid hormone beta caused by a novel <i>THRB</i> gene mutation and coexisting pituitary microadenoma. A 41-year-old Thai woman presented with elevated serum thyroid hormone levels and non-suppressed TSH. MRI showed a 4x2-mm pituitary adenoma. Five of her relatives had similar thyroid tests abnormalities, but a sister had Graves' disease. TPO and TG antibodies were positive in all affected family members except for a 4.5 year-old. Lack of thyrotoxic symptoms and TSH suppression by T3, indicated incidentaloma rather than a TSH-secreting pituitary adenoma...
October 19, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27696232/correlation-of-braf-mutation-and-suvmax-levels-in-thyroid-cancer-patients-incidentally-detected-in-18-f-fluorodeoxyglucose-positron-emission-tomography
#2
Aysenur Ozderya, Sule Temizkan, Aylin Ege Gul, Sule Ozugur, Mehmet Sargin, Kadriye Aydin
The prognostic importance of (18)F-fluorodeoxyglucose avidity in primary thyroid tumor and molecular basis responsible for its mechanism has not yet been well characterized. In this study, we aimed to evaluate the correlation between the maximum standardized uptake levels and B-type Raf kinase mutation positivity in incidentally detected papillary thyroid cancer patients during (18)F-fluorodeoxyglucose positron emission tomography examination. We retrospectively evaluated 6873 (18)F-fluorodeoxyglucose-positron emission tomography scans of consecutive subjects from a database search for tumor staging in 2014 at our hospital Nuclear Medicine Center...
October 1, 2016: Endocrine
https://www.readbyqxmd.com/read/27612034/the-incidence-of-thyroid-cancer-in-focal-hypermetabolic-thyroid-lesions-an-18f-fdg-pet-ct-study-in-more-than-6000-patients
#3
Martin Barrio, Johannes Czernin, Michael W Yeh, Miguel F Palma Diaz, Pawan Gupta, Martin Allen-Auerbach, Christiaan Schiepers, Ken Herrmann
BACKGROUND: The clinical significance of incidental thyroid abnormalities discovered in fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) (FDG PET/CT) studies remains controversial. The aim of this large retrospective study was to (a) determine the prevalence of focal F-FDG thyroid uptake on whole-body F-FDG PET/CT studies carried out for nonthyroid cancers and (b) to test whether intense focal F-FDG thyroid uptake is associated with malignancy. MATERIALS AND METHODS: A total of 11 921 F-FDG PET/CT studies in 6216 patients carried out at our institution between January 2012 and December 2014 were analyzed...
December 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27571130/fluorine-18-fluorodeoxyglucose-avid-thyroid-incidentalomas-on-pet-ct-scan-in-cancer-patients-how-sinister-are-they
#4
Aamna Hassan, Saima Riaz, Waleed Zafar
OBJECTIVE: To evaluate the prevalence of malignancy in incidental thyroidal uptake on PET with fluorine-18 deoxyglucose integrated with computed tomography (F-FDG PET/CT) in Pakistani cancer patients and to assess the role of standardized uptake value (SUV) in deciding which lesions to investigate further. METHOD: We retrospectively reviewed all patients who underwent F-FDG PET/CT scans over a period of 59 months and further analysed those with visually increased thyroidal uptake...
October 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27513265/the-incidence-of-18f-fdg-pet-ct-thyroid-incidentalomas-andthe-prevalence-of-malignancy-a-prospective-study
#5
Mine Şencan Eren, Özhan Özdoğan, Arzu Gedik, Mehmet Ceylan, Merih Güray Durak, Mustafa Seçil, Mehmet Ali Koçdor, Abdurrahman Çömlekçi, Hatice Durak
BACKGROUND/AIM: To determine the prevalence of malignancy in thyroid incidentalomas (TIs) detected by fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). MATERIALS AND METHODS: 18F-FDG PET/CT images were evaluated prospectively for the presence of thyroid uptake. The patients with a TI were evaluated by an endocrinologist according to the predefined diagnostic algorithm. The final diagnosis was obtained clinically and/or by pathology...
2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27504349/diagnostic-dilemma-in-a-thyroid-incidentaloma-second-primary-versus-metastatic-nodule
#6
Abid Ali Mirza, Esha Pai, Kodaganur Gopinath Srinivas, Shankarappa Amarendra, K S Gopinath
With the increasing use of 18F-Fluro-Deoxyglucose (FDG) Positron Emission Tomography (PET) the number of thyroid incidentalomas is on the rise. Focal thyroid incidentalomas identified by FDG-PET have been reported to have a high incidence of malignancy. Neuroendocrine tumours of the thyroid are rare entities. The most common neuroendocrine tumour of the thyroid is medullary carcinoma. A thyroid nodule in a patient with a known neuroendocrine tumour must be differentiated from a primary medullary carcinoma which can present as a diagnostic challenge to the clinician...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27424217/simultaneous-pet-mri-vs-pet-ct-in-oncology-a-systematic-review
#7
C Riola-Parada, L García-Cañamaque, V Pérez-Dueñas, M Garcerant-Tafur, J L Carreras-Delgado
OBJECTIVE: The aim of this review was to evaluate the diagnostic performance of simultaneous PET/MRI in oncology compared with that of PET/CT, based upon the available evidence. MATERIAL AND METHODS: A systematic search was performed in the Medline and Embase databases to identify original clinical articles published up to 21 January 2016, in order to compare simultaneous PET/MRI and PET/CT in oncology patients. RESULTS: A total of 57 articles were obtained that included various diseases: head and neck cancer (5), lung cancer and lung nodules (13), colorectal cancer (1), liver lesions (2), abdominal incidentalomas (1), neuroendocrine tumours (2), thyroid carcinoma (2), breast cancer (3), gynaecological cancer (2), prostate cancer (4), lymphoma (2), multiple myeloma (1), bone metastases (3), intracranial tumours (2), paediatric oncology (1) and various tumours (13)...
September 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/27230389/charting-a-course-through-the-ceas-diagnosis-and-management-of-medullary-thyroid-cancer
#8
Christopher W Rowe, Cino Bendinelli, Shaun McGrath
Medullary thyroid cancer (MTC) is an uncommon thyroid cancer that requires a high index of suspicion to facilitate diagnosis of early-stage disease amenable to surgical cure. The challenges of diagnosis, as well as management in the setting of persistent disease, are explored in the context of a case presenting with the incidental finding of elevated carcinoembryonic antigen (CEA) and an (18) F-fluorodeoxyglucose positron emission tomography ((18) F-FDG-PET)-positive thyroid incidentaloma detected following treatment of colorectal cancer...
September 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27146775/positron-emission-tomography-thyroid-incidentaloma-is-it-different-in-indian-subcontinent
#9
R Vaish, R Venkatesh, D A Chaukar, A D Deshmukh, N C Purandare, A K D'cruz
BACKGROUND: Positron emission tomography (PET) forms an integral part in work-up and follow-up of various malignancies. With the increased use of PET in oncology, finding of an incidental focal thyroid uptake (incidentaloma) is not unusual and presents a diagnostic challenge. AIM: The aim of the following study is to evaluate the frequency and radio-pathologic correlation of focal 18-fluoro deoxyglucose uptake (FDG) on PET within the thyroid from a large series...
January 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/27028799/developing-a-registry-for-thyroid-incidentalomas-lessons-learned-and-the-path-forward
#10
Louise Davies, Erin Pichiotino, William C Black, Anna N A Tosteson
BACKGROUND: Incidentalomas are findings on an imaging test done for other reasons, for which there are no matching symptoms in the patient. They are common in the adrenal gland, pancreas, liver, and thyroid, among other sites. Incidentalomas are a problem because we have a limited understanding of their natural history: it is difficult to know how much of a threat they pose to individual patients. An observational registry that would allow a systematic study of thyroid incidentalomas could reveal their natural history and the effect of detection on patients' lives, as well as document the cost to the healthcare system...
May 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/26963467/clinical-significance-of-thyroid-incidentalomas-identified-by-18f-fdg-pet-ct-correlation-of-ultrasonograpy-findings-with-cytology-results
#11
Özgür Demir, Naziyet Köse, Elgin Özkan, Uğur Ünlütürk, Gülseren Aras, Murat Faik Erdoğan
AIM: The aim of this study was to investigate the clinical importance of incidental focal or diffuse fluorine-18 fluorodeoxyglucose (F-FDG) uptake in the thyroid gland on positron emission tomography (PET)/computed tomography (CT) and to evaluate the additive value of thyroid ultrasonography (US) in defining the malignancy potential of thyroid incidentalomas. PATIENTS AND METHODS: A total of 1450 patients, who had undergone a PET/CT scan for staging or restaging of various malignancies, were screened retrospectively and 52 (3...
July 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/26919607/thyroid-nodules-detected-by-contrast-enhanced-magnetic-resonance-angiography-prevalence-and-clinical-significance
#12
Hyun Kyung Lim, Sung Tae Park, Hongil Ha, Seo-youn Choi
BACKGROUND AND PURPOSE: Incidental thyroid lesions are frequently found on contrast-enhanced magnetic resonance (CE-MR) angiography. The purpose of this study is to determine the prevalence of thyroid incidentalomas detected by CE-MR angiography and to evaluate their clinical significance by correlation with ultrasound (US) and cytopathological results. MATERIALS AND METHODS: We retrospectively reviewed 3,299 consecutive CE-MR angiography examinations performed at our institution between January 2010 and March 2013...
2016: PloS One
https://www.readbyqxmd.com/read/26904704/the-importance-of-exclusion-of-obstructive-sleep-apnea-during-screening-for-adrenal-adenoma-and-diagnosis-of-pheochromocytoma
#13
Alicia C Weeks, Michelle E Kimple, Dawn Belt Davis
Context. As catecholamine elevation is a key element in the diagnosis of pheochromocytoma, more commonplace causes of sympathetic excess, such as obstructive sleep apnea (OSA), should be excluded as standard practice prior to diagnosis. This is essential to avoid misdiagnosis of adrenal incidentalomas identified in the estimated 42 million Americans with OSA, with greater than 4 million projected to undergo a computed tomography study annually. Case Description. A 56-year-old woman presented with a several year history of paroxysmal hypertension, palpitations, and diaphoresis...
July 2015: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/26556493/-do-not-always-puncture-a-thyroid-nodule
#14
REVIEW
Bart Dorgelo, Johannes W A Smit, Thera P Links
The incidence of thyroid cancer is increasing, especially the papillary subtype. This increase can be mainly attributed to the detection of small - mostly indolent - papillary thyroid cancers as a consequence of the higher sensitivity of diagnostic techniques and the more frequent use of diagnostic applications. Two patients are described with (non-)palpable thyroid nodules to illustrate the risk of overdiagnostics and overtreatment. A thyroid incidentaloma detected on ultrasound, CT or MRI does not require further diagnostic procedures as standard...
2015: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/26508893/management-of-a-thyroid-incidentaloma-in-a-patient-with-cancer-a-case-report
#15
Charles Dearman, Esme J Hill, Jamie M Franklin, Greg P Sadler, Lai Mun Wang, Michael A Silva, Ricky A Sharma
The routine use of (18)F-fluorodeoxyglucose-positron emission tomography (PET)/computed tomography scans for staging and assessment of treatment response for cancer has resulted in a large number of thyroid abnormalities being detected as incidental findings ("incidentalomas"). Since most PET/CT scans are performed in the setting of a known nonthyroid malignancy, the need for "incidentalomas" to be further investigated and managed depends on the stage, prognosis, and current treatment plan for the known malignancy...
2015: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/26376643/incidentalomas-during-imaging-for-primary-hyperparathyroidism-incidence-and-clinical-outcomes
#16
P Prasad, C Clout, E Lorenz, B J Harrison, S P Balasubramanian
BACKGROUND: Imaging for pre-operative localisation of parathyroid glands in primary hyperparathyroidism is now routine. This has led to the detection of incidental lesions (incidentalomas) in other organs, the nature of which is not well characterised. The aim of this study was to determine the incidence, characteristics and outcomes in patients who had incidental findings on parathyroid imaging. METHODS: Records of patients who underwent imaging for primary hyperparathyroidism over 2 years were reviewed to identify incidental lesions detected on parathyroid imaging...
2015: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26346886/can-elastography-predict-growth-of-incidental-thyroid-nodules-a-pilot-two-year-follow-up-study
#17
Anne Krejbjerg, Inge Bülow Pedersen, Peter Laurberg
The objective of this study was to examine the ultrasonography (US) and ultrasound elastography (USE) features of thyroid incidentalomas in a population exposed to iodine deficiency and to investigate whether baseline elasticity scores (ES) predicted changes in thyroid nodule US characteristics. We conducted a two-year follow-up pilot study of thyroid incidentalomas by US and USE. One sonographer performed the US and USE examination on the same apparatus at baseline and at follow-up. We evaluated 83 incidental thyroid nodules detected in a population study...
September 2016: Ultrasonic Imaging
https://www.readbyqxmd.com/read/26335604/risk-stratification-of-thyroid-incidentalomas-found-on-pet-ct-the-value-of-iodine-content-on-noncontrast-computed-tomography
#18
Dongwoo Kim, Sang Hyun Hwang, Jongtae Cha, Kwanhyeong Jo, Narae Lee, Mijin Yun
BACKGROUND: The Hounsfield unit (HU) ratio of thyroid nodules was assessed compared to the contralateral thyroid lobe on noncontrast computed tomography (CT) to stratify further the risk of malignancy in thyroid incidentalomas found on 18F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/CT (PET/CT). METHODS: This retrospective analysis included 82 patients who had thyroid incidentalomas on PET/CT in 2011. On PET/CT, the maximal standardized uptake value ratios of the thyroid nodule compared to liver (T/BSUV) and the HU ratios of the thyroid nodule compared to contralateral thyroid lobe (T/BHU) were calculated...
November 2015: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/26205646/incidental-thyroid-lesions-on-fdg-pet-ct-a-prevalence-study-and-proposition-of-management
#19
M Adas, G Adas, B Koc, F Ozulker
AIM: Thyroid incidentaloma is defined as an unsuspected, asymptomatic thyroid lesion that is discovered on an imaging study. The purpose of this study is to determine incidentally identified thyroid lesions by FDG-PET/CT in cancer patients by virtue of preoperative staging and to pay attention how should be the management of these patients with thyroid lesion. METHODS: From January 2011 to January 2013, 2654 patients underwent FDG-PET/CT in our institution. Among them, 34 patients had thyroid incidentaloma...
September 2015: Minerva Endocrinologica
https://www.readbyqxmd.com/read/26160694/benign-and-malignant-thyroid-incidentalomas-are-rare-in-routine-clinical-practice-a-review-of-97-908-imaging-studies
#20
Abhineet Uppal, Michael G White, Sapna Nagar, Briseis Aschebrook-Kilfoy, Paul J Chang, Peter Angelos, Edwin L Kaplan, Raymon H Grogan
PURPOSE: Thyroid nodules incidentally identified on imaging are thought to contribute to the increasing incidence of thyroid cancer. We aim to determine the true rate of incidental thyroid nodule reporting, malignancy rates of these nodules, and to compare these findings with rates of detection by dedicated radiology review. METHODS: A cross-sectional analysis was done to determine the prevalence of thyroid nodules in radiologist reports by analyzing all reports for CT, PET, and MRI scans of the head, neck, and chest as well as neck ultrasounds performed at a tertiary care center from 2007 to 2012...
September 2015: Cancer Epidemiology, Biomarkers & Prevention
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