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https://www.readbyqxmd.com/read/27910781/inhibition-of-dimethylbenz-a-anthracene-dmba-croton-oil-induced-mouse-skin-tumorigenesis-by-gmelina-arborea-with-potential-anti-inflammatory-activity
#1
Lincy Lawrence, Seema Menon, Divya Menon K, Vipin P Sivaram, Jose Padikkala
In traditional Indian medicine, the plant Gmelina arborea Linn. (GA) is described to have the ability to relieve edema. The present study evaluates the anticancer property of GA stem bark against 7,12-dimethylbenz(a) anthracene (DMBA)-croton oil-induced skin tumorigenesis along with the evaluation of anti-inflammatory activity. The observed inhibition of inflammation in carrageenan-induced (41.8%) and formalin-induced (34.07%) models may be due to inhibition of prostaglandins (PGs). Skin papilloma was induced by a single topical application of DMBA (470 nmol/200 µL acetone), followed by repeated application of croton oil (1% in 200 µL acetone)...
2016: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/27904397/antibacterial-activity-of-indian-borage-plectranthus-amboinicus-benth-leaf-extracts-in-food-systems-and%C3%A2-against-natural-microflora-in-chicken-meat
#2
Sandeep Kumar Gupta, Pradeep Singh Negi
The ability of acetone and ethyl acetate extracts of the leaves of a traditional Indian medicinal plant, Indian borage (Plectranthus amboinicus Benth) to prevent spoilage of artificially inoculated model food systems (cabbage and papaya) and natural microflora of chicken meat was evaluated. These extracts were able to reduce the bacterial counts in all food systems; however, the effective concentration varied with the complexity of the system (cabbage<papaya<chicken). A probable mode of action of extracts was investigated by analyzing the changes they cause in bacterial cell wall and leakage of nucleic acid from bacterial cells...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27888157/curcumin-use-in-pulmonary-diseases-state-of-the-art-and-future-perspectives
#3
REVIEW
Diana Lelli, Amirhossein Sahebkar, Thomas P Johnston, Claudio Pedone
Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa). It has been used for centuries in Ayurveda (Indian traditional medicine) for the treatment of several diseases. Over the last several decades, the therapeutic properties of curcumin have slowly been elucidated. It has been shown that curcumin has pleiotropic effects, regulating transcription factors (e.g., NF-kB), cytokines (e.g., IL6, TNF-alpha), adhesion molecules (e.g., ICAM-1), and enzymes (e.g., MMPs) that play a major role in inflammation and cancerogenesis...
November 22, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27881265/importance-of-economic-evaluation-in-health-care-an-indian-perspective
#4
Amit Dang, Nishkarsh Likhar, Utkarsh Alok
Health economic studies provide information to decision makers for efficient use of available resources for maximizing health benefits. Economic evaluation is one part of health economics, and it is a tool for comparing costs and consequences of different interventions. Health technology assessment is a technique for economic evaluation that is well adapted by developed countries. The traditional classification of economic evaluation includes cost-minimization, cost-effectiveness analysis, cost-utility analysis, and cost-benefit analysis...
May 2016: Value in Health Regional Issues
https://www.readbyqxmd.com/read/27877231/chemomodulatory-potential-of-bartogenic-acid-against-dmba-croton-oil-induced-two-step-skin-carcinogenesis-in-mice
#5
Chandragouda R Patil, Bhavin M Sonara, Umesh B Mahajan, Kalpesh R Patil, Dipak D Patil, Ramchandra B Jadhav, Sameer N Goyal, Shreesh Ojha
Barringtonia racemosa fruits are believed to be useful in cancer treatment in Ayurveda, the Indian system of medicine. In present study, bartogenic acid (BA), a triterpenoid constituent of Barringtonia fruits was evaluated for its cytotoxicity property using the human skin carcinoma cell line (SCC-13) and human peripheral blood mononuclear cells (PBMC). The chemopreventive efficacy of BA was evaluated against the DMBA/Croton oil-induced skin carcinogenesis in mice.BA was orally administered at the doses of 1, 2 or 4 mg/kg/day or applied topically every day for 12 weeks following DMBA application...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27856571/draft-genome-sequence-of-lactobacillus-plantarum-kanjika-2007-isolated-from-kanjika-a-south-indian-traditional-food
#6
G Divyashri, K Rajagopal, S G Prapulla
The draft genome sequence of Lactobacillus plantarum Kanjika 2007, isolated from the South Indian staple, medicinal, and traditional food kanjika, is reported here. The whole genome consists of 3.16 Mb with a G+C content of 44.7% and 3,009 protein-coding genes, 78 tRNAs, and 4rRNAs (5S-23S-16S).
November 17, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27828673/building-inclusive-health-innovation-systems-lessons-from-india
#7
Dinesh Abrol, T Sundararaman, Harilal Madhavan, K J Joseph
This article presents an overview of the changes that are taking place within the public and private health innovation systems in India including delivery of medical care, pharmaceutical products, medical devices, and Indian traditional medicine. The nature of the flaws that exist in the health innovation system is pinpointed. The response by the government, the health, technology and medical institutions, and the evolving industry is addressed on a national level. The article also discusses how the alignment of policies and institutions was developed within the scope of national health innovation systems, and how the government and the industry are dealing with the challenges to integrate health system, industry, and social policy development processes...
November 3, 2016: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/27822251/immunostimulatory-effect-of-the-aqueous-leaf-extract-of-phyllanthus-niruri-on-the-specific-and-nonspecific-immune-responses-of-oreochromis-mossambicus-peters
#8
M Muthulakshmi, P A Subramani, R D Michael
Plant derived immunostimulants are a promising alternative to chemotherapeutics and also perhaps vaccines. In the present study, we examined the immunostimulating properties of aqueous leaf extract of Phyllanthus niruri, an Indian traditional medicinal herb, on neutrophil activation and antibody response of Oreochromis mossambicus (Peters). Serial ten-fold diluted doses of P. niruri ranging from 0.002 mg to 20 mg were administered to two groups of O. mossambicus (n=8). One group of fishes was administered with sheep red blood cells and the primary and secondary antibody responses were estimated using direct haemagglutination assay...
2016: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/27816659/ethnopharmacological-appraisal-of-culturally-important-medicinal-plants-and-polyherbal-formulas-used-against-communicable-diseases-in-rodrigues-island
#9
Anne Kathie Samoisy, Fawzi Mahomoodally
ETHNOPHARMACOLOGICAL RELEVANCE: The tropical island of Rodrigues is one of three islands that constitute the Mascarene archipelago in the Indian Ocean. Currently considered as a biodiversity hotspot, the island has also a resilient history in the use of traditional medicine. However, there has been no ethnopharmacological study to document quantitatively such traditional practice against communicable diseases (CD), which currently accounts for 6.61% annual death and 30.7% attendances in public hospitals...
November 2, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27774424/anti-arthritic-activity-of-a-classical-ayurvedic-formulation-vatari-guggulu-in-rats
#10
Madhavi G Patel, Kilambi Pundarikakshudu
In India, Vatari Guggulu has been traditionally used in the Ayurvedic system of medicine to treat rheumatoid arthritis (RA). The current study was undertaken to evaluate anti-arthritic activity of alcoholic extract of Vatari Guggulu in rats. Arthritis was induced by administration of formaldehyde (2%v/v) or Complete Freund's Adjuvant (CFA) into the sub-plantar surface of left hind paw of the animals. The extract was administered to the rats by oral gavages in different doses. Joint swelling was measured in formaldehyde induced arthritis...
October 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27774419/evaluation-of-anti-inflammatory-activity-of-selected-medicinal-plants-used-in-indian-traditional-medication-system-in%C3%A2-vitro-as-well-as-in%C3%A2-vivo
#11
Rafik U Shaikh, Mahesh M Pund, Rajesh N Gacche
The present study was carried out to evaluate in vivo and in vitro anti-inflammatory potential of selected medicinal plants used in Indian traditional medication. The sequentially extracted plant samples as, Cissus quadrangularis, Plumbago zeylanica, Terminalia bellarica and Terminalia chebula in water, ethanol and hexane were evaluated in-vitro for COX-1 and 2 inhibitory and antioxidant activities. The in vivo anti-inflammatory activity of selected samples showing promising COX-2 inhibition was assessed using carrageenan and Phorbol Myristate Acetate (PMA) induced mice edema animal model...
October 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27761078/postprandial-antihyperglycemic-and-antioxidant-activities-of-acalypha-indica-linn-stem-extract-an-in-vivo-study
#12
Charles Lekhya Priya, K V Bhaskara Rao
BACKGROUND: α-glucosidase inhibitors controls postprandial hyperglycemia (PPHG) by lowering sharp rise in blood glucose levels after ingestion of carbohydrate rich meal in type 2 diabetic (T2D) individuals. Acalypha indica commonly known as Indian copper leaf is used in traditional medicinal system to treat various diseases. In our previous in-vitro investigation, methanolic extract of A. indica stems (AIS) proved to be an effective a-glucosidase inhibitor, antioxidant, and well tolerated in acute and subchronic toxicity studies in albino wistar rats...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27761072/sambar-an-indian-dish-prevents-the-development-of-dimethyl-hydrazine-induced-colon-cancer-a-preclinical-study
#13
Vutturu Ganga Prasad, Neetinkumar Reddy, Albi Francis, Pawan G Nayak, Anoop Kishore, Krishnadas Nandakumar, Mallikarjuna C Rao, Rekha Shenoy
BACKGROUND: Colon cancer (CC) is the third commonly diagnosed cancer and the second leading cause of mortality in the US when compared to India where prevalence is less. Possible reason could be the vegetarian diet comprising spices used in curry powders. Researchers believe that 70% of the cases are associated with diet. Spices have inherited a rich tradition for their flavor and medicinal properties. Researchers have been oriented towards spices present in food items for their antitumorigenic properties...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27757269/anthelmintic-activity-of-a-standardized-extract-from-the-rhizomes-of-acorus-calamus-linn-acoraceae-against-experimentally-induced-cestodiasis-in-rats
#14
Purobi Nath, Arun K Yadav
BACKGROUND: The rhizomes of a herb Acorus calamus Linn. (Acoraceae) have been widely used as a traditional medicine to cure intestinal-helminthic infections in India and South Africa. AIM: This study was undertaken to investigate the in vivo anthelmintic activity of a standardized methanolic extract obtained from the rhizomes A. calamus in a rodent model. MATERIALS AND METHODS: A methanolic extract obtained from rhizomes of A. calamus was characterized for active principle using nuclear magnetic resonance (1)H NMR, (13)C NMR, mass and infrared spectroscopy...
September 2016: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/27752245/therapeutic-potential-and-molecular-mechanisms-of-emblica-officinalis-gaertn-in-countering-nephrotoxicity-in-rats-induced-by-the-chemotherapeutic-agent-cisplatin
#15
Salma Malik, Kapil Suchal, Jagriti Bhatia, Sana I Khan, Swati Vasisth, Ameesha Tomar, Sameer Goyal, Rajeev Kumar, Dharamvir S Arya, Shreesh K Ojha
Emblica officinalis Gaertn. belonging to family Euphorbiaceae is commonly known as Indian gooseberry or "Amla" in India. It is used as a 'rejuvenating herb' in traditional system of Indian medicine. It has been shown to possess antioxidant, anti-inflammatory and anti-apoptotic effects. Thus, on the basis of its biological effects, the present study was undertaken to evaluate the protective effect of the dried fruit extract of the E. Officinalis (EO) in cisplatin-induced nephrotoxicity in rats and also to evaluate the mechanism of its nephroprotection...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27748812/protective-effects-of-centella%C3%A2-asiatica-leaf-extract-on-dimethylnitrosamine%C3%A2-induced-liver-injury-in-rats
#16
Myung-Joo Choi, Hong-Mei Zheng, Jae Min Kim, Kye Wan Lee, Yu Hwa Park, Don Haeng Lee
Oxidative stress in liver injury is a major pathogenetic factor in the progression of liver damage. Centella asiatica (L.) Urban, known in the United States as Gotu kola, is widely used as a traditional herbal medicine in Chinese or Indian Pennywort. The efficacy of Centella asiatica is comprehensive and is used as an anti‑inflammatory agent, for memory improvement, for its antitumor activity and for treatment of gastric ulcers. The present study investigated the protective effects of Centella asiatica on dimethylnitrosamine (DMN)‑induced liver injury in rats...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27744374/the-tribal-tobacco-education-and-policy-initiative-findings-from-a-collaborative-participatory-evaluation
#17
Sheryl Scott, Joanne D'Silva, Carol Hernandez, Nicole Toves Villaluz, Jaime Martinez, Chris Matter
While the reduction in the overall U.S. smoking prevalence has been declared one of the top 10 public health achievements of the past century, the growing disparity in smoking between American Indians and the general population is one of the biggest challenges of the 21st century. Minnesota in particular has very high smoking rates among American Indians (59%). Tribal Nations in Minnesota share a past of attempted cultural genocide and a present of restoring the strength of their cultural teachings, including the prominence of traditional tobacco as a sacred "first medicine...
October 14, 2016: Health Promotion Practice
https://www.readbyqxmd.com/read/27739063/the-natural-camp-elevating-compound-forskolin-in-cancer-therapy-is-it-time
#18
REVIEW
Luigi Sapio, Monica Gallo, Michela Illiano, Emilio Chiosi, Daniele Naviglio, Annamaria Spina, Silvio Naviglio
Cancer is a major public health problem and the second leading cause of mortality around the world. Although continuous advances in the science of oncology and cancer research are now leading to improved outcomes for many cancer patients, novel cancer treatment options are strongly demanded. Naturally occurring compounds from a variety of vegetables, fruits, and medicinal plants have been shown to exhibit various anticancer properties in a number of in vitro and in vivo studies and represent an attractive research area for the development of new therapeutic strategies to fight cancer...
October 14, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27711824/the-effect-of-a-plant-extract-enriched-in-stigmasterol-and-%C3%AE-sitosterol-on-glycaemic-status-and-glucose-metabolism-in-alloxan-induced-diabetic-rats
#19
Ramith Ramu, Prithvi S Shirahatti, Shivasharanappa Nayakavadi, Vadivelan R, Farhan Zameer, Bhadrapura Lakkappa Dhananjaya, Nagendra Prasad Mn
Banana is an extensively cultivated plant worldwide, mainly for its fruit, while its ancillary product, the banana pseudostem, is consumed as a vegetable and is highly recommended for diabetics in the traditional Indian medicine system. The present study was aimed at elucidating the mechanism of antihyperglycaemia exerted by the ethanol extract of banana pseudostem (EE) and its isolated compounds viz., stigmasterol (C1) and β-sitosterol (C2), in an alloxan-induced diabetic rat model. Diabetic rats which were administered with C1, C2 and EE (100 and 200 mg per kg b...
September 14, 2016: Food & Function
https://www.readbyqxmd.com/read/27707902/the-significance-of-ayurvedic-medicinal-plants
#20
Syal Kumar, Gustav J Dobos, Thomas Rampp
Traditional Indian medicine (ayurveda) is becoming increasingly popular, with many chronic conditions responding to it well. Most patients begin to take conventional medications as soon as their diagnoses are made, so ayurvedic treatments are usually undergone alongside and/or after conventional medical approaches. A detailed knowledge of the action of food, spices, and medicinal plants is needed in order to understand their potential influence fully. While societal use of ayurvedic plants and Indian spices is commonplace, without ill effect, the use of more concentrated products made from single plants, often in the form of teas or tablets, is of more concern...
October 5, 2016: Journal of Evidence-based Complementary & Alternative Medicine
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