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https://www.readbyqxmd.com/read/28922612/analysis-of-levodopa-content-in-commercial-mucuna-pruriens-products-using-high-performance-liquid-chromatography-with-fluorescence-detection
#1
Amala Soumyanath, Tanya Denne, Amie Hiller, Shaila Ramachandran, Lynne Shinto
OBJECTIVES: Mucuna pruriens (MP) seeds contain levodopa (up to 2% by weight) and have been used in traditional Indian medicine to treat an illness named "Kampavata," now understood to be Parkinson's disease (PD). Studies have shown MP to be beneficial, and even superior, to levodopa alone in treating PD symptoms. Commercial products containing MP are readily available from online and retail sources to patients and physicians. Products often contain extracts of MP seeds, with significantly higher levodopa content than the seeds...
September 18, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28921713/chebulinic-acid-isolated-from-the-fruits-of-terminalia-chebula-specifically-induces-apoptosis-in-acute-myeloid-leukemia-cells
#2
Stuti Chhabra, Tripti Mishra, Yogesh Kumar, Gatha Thacker, Sanjeev Kanojiya, Naibedya Chattopadhyay, Tadigoppula Narender, Arun Kumar Trivedi
Chebulinic acid, an ellagitannin found in the fruits of Terminalia chebula, has been extensively used in traditional Indian system of medicine. It has shown to have various biological activities including antitumor activity. The present study aims to investigate the cytotoxic potential of chebulinic acid in human myeloid leukemia cells. Interestingly, chebulinic acid caused apoptosis of acute promyelocytic leukemia HL-60 and NB4 cells but not K562 cells. In vitro antitumor effects of chebulinic acid were investigated by using various acute myeloid leukemia cell lines...
September 18, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28914436/chinese-and-indian-women-s-experience-with-alternative-medications-for-menopause-related-symptoms-a-qualitative-analysis
#3
Saw Ohn Mar, Fatehpal Singh Malhi, Syed Hamid Syed Rahim, Myint Myint Soe
OBJECTIVE: To explore women's rationalization for using alternative medications, their experience and view on safety of long-term use. METHODS: Two focus group discussions, involving 5 participants each for Chinese and Indian groups, were conducted separately. Participant's personal information was collected anonymously. The discussion covered 5 areas: determinants for taking medications; reason for choosing alternative medications rather than hormone replacement therapy (HRT); how these medications help them; their view on cost-effectiveness and concerns over long-term use...
September 15, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28899496/neem-azadirachta-indica-an-indian-traditional-panacea-with-modern-molecular-basis
#4
REVIEW
Subash Chandra Gupta, Sahdeo Prasad, Amit K Tyagi, Ajaikumar B Kunnumakkara, Bharat B Aggarwal
BACKGROUND: For centuries, agents derived from natural sources (mother nature), especially plants have been the primary source of medicine. Neem, also referred to as Azadirachta indica is one such plant that has been so named because it provides freedom from all diseases, and used for thousands of years in Indian and African continents. Different parts of the plant including flowers, leaves, seeds and bark have been used to treat both acute and chronic human diseases; and used as insecticide; antimicrobial, larvicidal, antimalarial, antibacterial, antiviral, and spermicidal...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28876177/ancient-indian-concepts-about-phenomenology-biology-and-therapeutics-of-epilepsy
#5
Ravindra Arya
This article discusses etiology, pathogenesis, symptoms, and treatment of epilepsy, as described in Charaka Samhitā (translation: Charaka's Compendium) and Sushruta Samhitā, the two core texts of Ayurveda, an ancient system of medicine. Ayurveda emphasized amnesia and loss of consciousness as core features of epileptic seizures (Sanskrit: apasmar; translation: apa negation, smaran memory) and recognized that seizures occur due to a disturbance in brain function or flow of "humors" to the brain. Semiology of various seizure types was well described...
September 6, 2017: Journal of the History of the Neurosciences
https://www.readbyqxmd.com/read/28875835/the-biological-potentialsof-indian-traditional-medicine-curcumin-for-treating-human-diseases
#6
C S Sumathi
Curcumin is an active compound extracted from the rhizomes of Curcuma longa L. (Turmeric). It possesses a di phenolic structure and there are three important fractions of curcumin namely curcumin, mono-desmethoxycurcumin and bis-desmethoxycurcumin. Curcumin is having high medicinal value. It is widely in Ayurveda, Siddha and Unani medicine formulations to treat various diseases. It is effective against microbial pathogens like bacteria, virus and fungi. It is highly potent and kills cancerous cells. Curcumin exhibits antioxidant activity and reduces lipoperoxidation...
August 30, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28867893/incubating-integrative-medicine-in-india-through-pmo-s-atal-incubator-scheme-of-niti-aayog
#7
EDITORIAL
Akshay Anand, Rahul Tyagi, Paramvir Kaur
BACKGROUND: Incubation centers are considered important tools to advance in a field of activity with multidisciplinary approach. The idea of incubation emerged long time back but it is actively pursued by funding agencies as a medium to propel community development. India's fast developing economy had limited tryst with Integrative Medicine until Indian Prime Minister, Narendra Modi, role modelled for Yoga in Chandigarh on the occasion of International Yoga Day. Integrative Medicine is a growing field and widely accepted as a cost-effective problem solving method that simplifies the management of incurable and complex disorders where modern medicine has little to offer...
July 2017: Annals of Neurosciences
https://www.readbyqxmd.com/read/28858391/pterocarpus-santalinus-l-regulated-ultraviolet-b-irradiation-induced-procollagen-reduction-and-matrix-metalloproteinases-expression-through-activation-of-tgf-%C3%AE-smad-and-inhibition-of-the-mapk-ap-1-pathway-in-normal-human-dermal-fibroblasts
#8
Wei Gao, Pei Lin, Eunson Hwang, Yushuai Wang, Zhengfei Yan, Hien T T Ngo, Tae-Hoo Yi
Ultraviolet light-induced reactive oxygen species (ROS) damage human skin and prematurely cause aging. A growing body of research is focusing on considering plants and plant-derived compounds as anti-photoaging therapeutic material. Pterocarpus santalinus L., as an Indian traditional medicine, possesses antidiabetic, anti-inflammatory and antioxidative effects. Here, we studied the anti-photoaging effects of ethanolic extract of P. santalinus L. heartwood (EPS) on ultraviolet radiation B (UVB)-irradiated normal human dermal fibroblasts (NHDFs)...
August 31, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28855820/in-vitro-alpha-amylase-inhibition-and-in-vivo-antioxidant-potential-of-momordica-dioica-seeds-in-streptozotocin-induced-oxidative-stress-in-diabetic-rats
#9
P Sailaja Rao, G Krishna Mohan
Momordica dioica Roxb. Commonly known as "Kakora" in Telugu, is used in the Indian traditional system of medicine for the treatment of diabetes. The aim of this study was to investigate the antidiabetic activity of methanolic extract of M. dioica seeds (MEMD) in streptozotocin (STZ) induced diabetic rats. The in vitro α-amylase inhibitory activity of the MEMD was done by spectrophotometric method. Diabetes was induced by STZ (45 mg/kg; i.p), MEMD (100 & 200 mg/kg; b.wt) and standard drug metformin (50 mg/kg; b...
September 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28843234/neem-seed-oil-induces-apoptosis-in-mcf-7-and-mda-mb-231-human-breast-cancer-cells
#10
Ramesh Sharma, Shweta Kaushik, Hari Shyam, Satish Agarwal, Anil Kumar Balapure
Background: In traditional Indian medicine, azadirachta indica (neem) is known for its wide range of medicinal properties. Various parts of neem tree including its fruit, seed, bark, leaves, and root have been shown to possess antiseptic, antiviral, antipyretic, anti-inflammatory, antiulcer, antimalarial, antifungal and anticancer activity. Materials and Methods: MCF-7 and MDA MB-231 cells were exposed to various concentrations of 2% ethanolic solution of NSO (1-30 μl/ml) and further processed for cell viability, cell cycle and apoptosis analysis...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28836997/ethnomedicinal-plants-used-by-local-inhabitants-of-jakholi-block-rudraprayag-district-western-himalaya-india
#11
Ankit Singh, Mohan C Nautiyal, Ripu M Kunwar, Rainer W Bussmann
BACKGROUND: Ethnomedicinal knowledge of the Indian Himalayas is very interesting because of the wide range of medicinal plants used in traditional medical practice. However, there is a danger of knowledge being lost because the knowledge sharing is very limited and passed on orally. The present study is the first ethnomedicinal study in Jakholi area of Rudraprayag district of Northwestern India. The aim of present study was to identify traditional medicinal plants used by the inhabitants to treat different ailments and document the associated knowledge of these medicinal plants...
August 24, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28835129/preclinical-renal-chemo-protective-potential-of-prunus-amygdalus-batsch-seed-coat-via-alteration-of-multiple-molecular-pathways
#12
Preeti Pandey, Prakash Chandra Bhatt, Mahfoozur Rahman, Dinesh Kumar Patel, Firoz Anwar, Fahad Al-Abbasi, Amita Verma, Vikas Kumar
Prunus amygdalus Batsch (almond) is a classical nutritive traditional Indian medicine. Along with nutritive with anti-oxidant properties, it is, clinically, used in the treatment of various diseases with underlying anti-oxidant mechanism. This study is an effort to scrutinise the renal protective effect of P. amygdalus Batsch or green almond (GA) seed coat extract and its underlying mechanism in animal model of Ferric nitrilotriacetate (Fe-NTA) induced renal cell carcinoma (RCC). RCC was induced in Swiss Albino Wistar rats by intraperitoneal injection of Fe-NTA...
August 24, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28832626/the-effect-of-bacopa-monnieri-on-gene-expression-levels-in-sh-sy5y-human-neuroblastoma-cells
#13
How-Wing Leung, Gabriel Foo, Gokulakrishna Banumurthy, Xiaoran Chai, Sujoy Ghosh, Tora Mitra-Ganguli, Antonius M J VanDongen
Bacopa monnieri is a plant used as a nootropic in Ayurveda, a 5000-year-old system of traditional Indian medicine. Although both animal and clinical studies supported its role as a memory enhancer, the molecular and cellular mechanism underlying Bacopa's nootropic action are not understood. In this study, we used deep sequencing (RNA-Seq) to identify the transcriptome changes upon Bacopa treatment on SH-SY5Y human neuroblastoma cells. We identified several genes whose expression levels were regulated by Bacopa...
2017: PloS One
https://www.readbyqxmd.com/read/28829812/use-of-traditional-eye-medicine-and-self-medication-in-rural-india-a-population-based-study
#14
Noopur Gupta, Praveen Vashist, Radhika Tandon, Sanjeev K Gupta, Mani Kalaivani, S N Dwivedi
OBJECTIVE: To determine the type and nature of traditional eye medicine (TEM), their sources and use and practices related to self-medication for ophthalmic diseases in a rural Indian population. METHODS: A population-based, cross-sectional study was conducted in 25 randomly selected clusters of Rural Gurgaon, Haryana, India as part of CORE (Cornea Opacity Rural Epidemiological) study. In addition to comprehensive ophthalmic examination, health-seeking behavior and use of self-medication and TEM was assessed in the adult population using a semi-structured questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28808384/molecular-authentication-of-the-traditional-medicinal-plant-lakshman-booti-smithia-conferta-sm-and-its-adulterants-through-dna-barcoding
#15
Suraj D Umdale, Parthraj R Kshirsagar, Manoj M Lekhak, Nikhil B Gaikwad
BACKGROUND: Smithia conferta Sm. is an annual herb widely used in Indian traditional medical practice and commonly known as "Lakshman booti" in Sanskrit. Morphological resemblance among the species of genus Smithia Aiton. leads to inaccurate identification and adulteration. This causes inconsistent therapeutic effects and also affects the quality of herbal medicine. AIM: This study aimed to generate potential barcode for authentication of S. conferta and its adulterants through DNA barcoding technique...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28806968/cardamom-powder-supplementation-prevents-obesity-improves-glucose-intolerance-inflammation-and-oxidative-stress-in-liver-of-high-carbohydrate-high-fat-diet-induced-obese-rats
#16
Md Mizanur Rahman, Mohammad Nazmul Alam, Anayt Ulla, Farzana Akther Sumi, Nusrat Subhan, Trisha Khan, Bishwajit Sikder, Hemayet Hossain, Hasan Mahmud Reza, Md Ashraful Alam
BACKGROUND: Cardamom is a well-known spice in Indian subcontinent, used in culinary and traditional medicine practices since ancient times. The current investigation was untaken to evaluate the potential benefit of cardamom powder supplementation in high carbohydrate high fat (HCHF) diet induced obese rats. METHOD: Male Wistar rats (28 rats) were divided into four different groups such as Control, Control + cardamom, HCHF, HCHF + cardamom. High carbohydrate and high fat (HCHF) diet was prepared in our laboratory...
August 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28783743/andrographis-paniculata-chu%C3%A4-n-x%C3%A4-n-li%C3%A3-n-for-symptomatic-relief-of-acute-respiratory-tract-infections-in-adults-and-children-a-systematic-review-and-meta-analysis
#17
Xiao-Yang Hu, Ruo-Han Wu, Martin Logue, Clara Blondel, Lily Yuen Wan Lai, Beth Stuart, Andrew Flower, Yu-Tong Fei, Michael Moore, Jonathan Shepherd, Jian-Ping Liu, George Lewith
INTRODUCTION: Antimicrobial resistance (AMR) is a substantial threat to public health. Safe and effective alternatives are required to reduce unnecessary antibiotic prescribing. Andrographis Paniculata (A. Paniculata, Chuān Xīn Lián) has traditionally been used in Indian and Chinese herbal medicine for cough, cold and influenza, suggesting a role in respiratory tract infections (RTIs). This systematic review aimed to evaluate the clinical effectiveness and safety of A. Paniculata for symptoms of acute RTIs (ARTIs)...
2017: PloS One
https://www.readbyqxmd.com/read/28757226/preparation-and-physicochemical-characterization-of-ingredients-of-indian-traditional-medicine-mahamrutyunjaya-rasa
#18
Pallavi Rai, Sadhana J Rajput
BACKGROUND: Mahamrutyunjaya rasa is an ayurvedic formulation used in the treatment of cardiac disorders. It contains the purified roots of Visa (Aconitum ferox), Brihati (Solanum indicum), fruits of Pippali Kana (Piper longum), Marica (Piper nigrum), Gandhaka (Sulfur), Hingula (Cinnabar) and Tankana (Sodium metaborate) as per Bhaishajya Ratnavali. The purification (shodhana) process changes the physiochemical properties of the raw materials which need to be studied and understood. OBJECTIVE: The present work aims to perform a comprehensive physicochemical characterization of raw materials, intermediates and the final product obtained during purification, using modern analytical techniques...
July 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28749102/an-exploration-of-phytochemicals-from-simaroubaceae
#19
REVIEW
Biba Vikas, B S Akhil, S R Suja, K Sujathan
Natural products such as plants, animals and minerals have been the basis of treatment of human diseases. Herbal remedies have been used for the treatment of many ailments. Many compounds have been derived from the plant species mentioned in the ancient texts of Indian system of medicine for the treatment of a number of ailments. The R and D thrust in the pharmaceutical sector is focused on development of new drugs, innovative/indigenous processes for known drugs and development of plant based drugs through investigation of leads from the traditional systems of medicine...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28730515/selective-induction-of-dna-damage-g2-abrogation-and-mitochondrial-apoptosis-by-leaf-extract-of-traditional-medicinal-plant-wrightia-arborea-in-k562-cells
#20
T Lakshmipriya, T Soumya, P R Jayasree, P R Manish Kumar
Plants have proved to be an important source of anti-cancer drugs. Wrightia arborea, an Indian Ayurvedic medicinal plant, is used traditionally to treat a variety of ailments. This study evaluates the antiproliferative/apoptotic potential of Wrightia arborea leaf extracts, prepared in different organic solvents, on cancer cell lines. MTT assay, light and fluorescence microscopy, flow cytometry, DNA laddering, alkaline comet assay, and western blotting were some of the techniques used for evaluation. Combinations of camptothecin, either with CHK1 inhibitor-PD407824 or with W...
July 20, 2017: Protoplasma
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