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https://www.readbyqxmd.com/read/28214539/lumbee-traditional-medicine-neuroprotective-activities-of-medicinal-plants-used-to-treat-parkinson-s-disease-related-symptoms
#1
Aurélie de Rus Jacquet, Michael Timmers, Sin Ying Ma, Andrew Thieme, George P McCabe, Jay Hansford C Vest, Mary Ann Lila, Jean-Christophe Rochet
ETHNOPHARMACOLOGICAL RELEVANCE: Parkinson's disease (PD) is a neurodegenerative disorder characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta and the presence in surviving neurons of Lewy body inclusions enriched with aggregated forms of the presynaptic protein α-synuclein (aSyn). Although current therapies provide temporary symptomatic relief, they do not slow the underlying neurodegeneration in the midbrain. In this study, we analyzed contemporary herbal medicinal practices used by members of the Lumbee tribe to treat PD-related symptoms, in an effort to identify safe and effective herbal medicines to treat PD...
February 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28211838/work-satisfaction-burnout-and-gender-based-inequalities-among-ophthalmologists-in-india-a-survey
#2
Akshay Gopinathan Nair, Pooja Jain, Aniruddha Agarwal, Vandana Jain
BACKGROUND: Ophthalmology is a rapidly evolving branch of medicine and advancing technology has raised the bar of patient expectations and outcomes. However, studies that assess physician stress and satisfaction especially in developing countries are limited in literature. OBJECTIVE: This index study aims at looking at the levels of job satisfaction, burnout and perception of gender disparity among ophthalmologists in India. METHODS: An Internet-based survey was sent out to ophthalmologists...
February 17, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28207892/triethylene-glycol-an-active-component-of-ashwagandha-withania-somnifera-leaves-is-responsible-for-sleep-induction
#3
Mahesh K Kaushik, Sunil C Kaul, Renu Wadhwa, Masashi Yanagisawa, Yoshihiro Urade
Insomnia is the most common sleep complaint which occurs due to difficulty in falling asleep or maintaining it. Most of currently available drugs for insomnia develop dependency and/or adverse effects. Hence natural therapies could be an alternative choice of treatment for insomnia. The root or whole plant extract of Ashwagandha (Withania somnifera) has been used to induce sleep in Indian system of traditional home medicine, Ayurveda. However, its active somnogenic components remain unidentified. We investigated the effect of various components of Ashwagandha leaf on sleep regulation by oral administration in mice...
2017: PloS One
https://www.readbyqxmd.com/read/28205343/association-of-chloride-intracellular-channel-4-and-indian-hedgehog-proteins-with-survival-of-patients-with-pancreatic-ductal-adenocarcinoma
#4
Qiong Zou, Zhulin Yang, Daiqiang Li, Ziru Liu, Yuan Yuan
Pancreatic cancer is the fourth most common cause of cancer-related mortality. Novel molecular biomarkers need to be identified for personalized medicine and to improve survival. The aim of this study was to examine chloride intracellular channel 4 (CLIC4) and Indian Hedgehog (Ihh) expression in benign and malignant lesions of the pancreas and to examine the eventual association between CLIC4 and Ihh expression, with clinicopathological features and prognosis of pancreatic cancer. A retrospective study of specimens collected from January 2000 to December 2011 at the Department of Pathology of the Second and Third Xiangya Hospitals, Central South University was undertaken to explore this question...
February 16, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28202601/cell-scientist-to-watch-arun-shukla
#5
(no author information available yet)
Arun Shukla received his master's degree in Biotechnology from the Jawaharlal Nehru University in New Delhi, and joined the lab of Nobel laureate Hartmut Michel at the Max Planck Institute of Biophysics in Frankfurt, Germany, for his PhD. He then moved to the United States for his postdoctoral work with Robert Lefkowitz at Duke University (Durham, NC) in a very close collaboration with Brian Kobilka (Stanford University, CA). Arun became an Assistant Professor in the Department of Medicine at Duke University in 2011, before returning to India in April 2014 as an Assistant Professor at the Indian Institute of Technology (IIT) in Kanpur as a Wellcome Trust DBT India Alliance Intermediate Fellow...
February 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28197028/gross-morphological-study-of-the-renal-pelvicalyceal-patterns-in-human-cadaveric-kidneys
#6
T S R Anjana, Elangovan Muthian, Sivakami Thiagarajan, Sumathi Shanmugam
INTRODUCTION: The knowledge of detailed calyceal anatomy is essential for performing urologic procedures such as percutaneous nephrolithotomy, percutaneous nephrostomy, flexible ureterorenoscopy, endopyelotomy, and retrograde renal surgery. This study was performed to analyze the various patterns of pelvicalyceal system in the South Indian population, and compare these with previously published studies in different populations. METHODS: The study was conducted in 100 kidney specimens...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28194337/development-of-statistics-as-a-discipline-for-clinical-research-past-present-and-future
#7
REVIEW
Chitra Lele
This article traces the history and evolution of statistics in the era of evidence based medicine, and focuses on the Indian perspective of this growth of statistics as a discipline for clinical research. Statistics will assume a more inter disciplinary form. Use of software other than SAS likely to grow further. In India, innovative statistical methods will help propel the development of biosimilars. The future is exciting with statistics being used for real world evidence, development of biosimilars, mining of adverse event data and becoming a core function in medicinal product development and lifecycle maintenance...
January 2017: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/28194332/regulatory-environment-for-clinical-research-recent-past-and-expected-future
#8
REVIEW
Amita Bhave, Suresh Menon
In the past few years, there have been numerous updates to policy and guidelines governing the conduct of clinical research in India. These measures were taken by regulators considering safety of Indian patients as the topmost priority although the overall regulatory environment became challenging. However, in the recent past, Indian regulations have evolved positively to favorably support clinical research in India while appropriately balancing patient safety as well. These regulatory changes are expected to bring newer innovative medicines to Indian patients at an earliest...
January 2017: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/28162117/setting-foundations-for-developing-disaster-response-metrics
#9
Mahshid Abir, Sue Anne Bell, Neha Puppala, Osama Awad, Melinda Moore
There are few reported efforts to define universal disaster response performance measures. Careful examination of responses to past disasters can inform the development of such measures. As a first step toward this goal, we conducted a literature review to identify key factors in responses to 3 recent events with significant loss of human life and economic impact: the 2003 Bam, Iran, earthquake; the 2004 Indian Ocean tsunami; and the 2010 Haiti earthquake. Using the PubMed (National Library of Medicine, Bethesda, MD) database, we identified 710 articles and retained 124 after applying inclusion and exclusion criteria...
February 6, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28162105/molecular-insights-into-cancer-therapeutic-effects-of-the-dietary-medicinal-phytochemical-withaferin-a
#10
Chandra Sekhar Chirumamilla, Claudina Pérez-Novo, Xaveer Van Ostade, Wim Vanden Berghe
Despite the worldwide research efforts to combat cancer, it remains a leading cause of death. Although various specific kinase inhibitors already have been approved for clinical cancer treatment, occurrence of intrinsic or acquired resistance and intermittent response over longer periods limits long-term success of single kinase-targeted therapies. In this respect, there is a renewed interest in polypharmaceutical natural compounds, which simultaneously target various hyperactivated kinases involved in tumour-inflammation, angiogenesis, cell survival, proliferation, metastasis and angiogenesis...
February 6, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28160866/withania-somnifera-chemotype-nmitli-101r-significantly-increases-the-efficacy-of-antileishmanial-drugs-by-generating-strong-ifn-%C3%AE-and-il-12-mediated-immune-responses-in-leishmania-donovani-infected-hamsters
#11
Chandra Dev Pati Tripathi, Pramod Kumar Kushawaha, Rajender Singh Sangwan, Chitra Mandal, Shailja Misra-Bhattacharya, Anuradha Dube
BACKGROUND: Withania somnifera (L.) Dunal (Solanaceae), commonly known as Ashwagandha, is one of the most important medicinal plant in the traditional Indian medical systems. Pharmacological studies have established that root extracts of W. somnifera contain several bioactive constituents called withanolides. The plant has long been used for its several beneficial properties and recently as an immunomodulator. HYPOTHESIS/PURPOSE: A combination therapy including a potential and safe immunostimulant with lower doses of effective drug, which can reduce the parasitic burden and simultaneously can produce an enhancement of adaptive immunity, has proven to be significantly a more effective approach than immunotherapy or drug therapy alone...
January 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28149832/critical-analysis-of-cardiovascular-and-central-nervous-system-fixed-dose-combinations-available-in-indian-market
#12
Krunal Prajapati, Samidh Shah, Mira Desai
INTRODUCTION: Fixed Dose Combinations (FDCs) are being increasingly used to improve compliance and achieve greater benefits of the two or more active ingredients given together than the corresponding individual drug components given separately. AIM: To analyse the rationality of Cardiovascular (CV) and Central Nervous System (CNS) FDCs available in Indian market. MATERIALS AND METHODS: CVS and CNS FDCs, enlisted in Indian Drug Review, 2014, were analysed by a pretested validated eight point criteria tool...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28139894/physiological-oral-melanin-pigmentation-in-a-south-african-sample-a-clinical-study
#13
Aubrey Masilana, Razia A G Khammissa, Johan Lemmer, Liviu Feller
AIM: Physiological oral melanin pigmentation is genetically determined, more frequently affecting people with darker skin. It can involve any oral mucosal site, but predominantly the gingiva. The aim of the present study was to determine the prevalence and to characterize the clinical features of physiological oral melanin pigmentation in a South African population sample. METHODS: A trainee in the discipline of periodontology and oral medicine interviewed all participants and examined the oral soft tissues...
January 31, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28123275/role-of-forensic-odontology-in-the-indian-armed-forces-an-unexplored-arena
#14
REVIEW
Karandeep Singh Arora, Prabhpreet Kaur
Forensic odontology (FO) is a branch of forensic medicine that in the interest of justice deals with proper handling and examination of dental evidence. Teeth can survive in most conditions encountered at death and during decomposition, even when the body is exposed to extreme forces and/or temperatures. FO is being practiced worldwide since 1775, after which it has not only become an integral part of the judicial system of the developed countries but also been adopted by the armed forces and investigative agencies of these countries...
September 2016: Journal of Forensic Dental Sciences
https://www.readbyqxmd.com/read/28120232/molecular-targets-of-the-phytocannabinoids-a-complex-picture
#15
Paula Morales, Dow P Hurst, Patricia H Reggio
For centuries, hashish and marihuana, both derived from the Indian hemp Cannabis sativa L., have been used for their medicinal, as well as, their psychotropic effects. These effects are associated with the phytocannabinoids which are oxygen containing C21 aromatic hydrocarbons found in Cannabis sativa L. To date, over 120 phytocannabinoids have been isolated from Cannabis. For many years, it was assumed that the beneficial effects of the phytocannabinoids were mediated by the cannabinoid receptors, CB1 and CB2...
2017: Progress in the Chemistry of Organic Natural Products
https://www.readbyqxmd.com/read/28115974/lippia-javanica-burm-f-spreng-traditional-and-commercial-uses-and-phytochemical-and-pharmacological-significance-in-the-african-and-indian-subcontinent
#16
REVIEW
Alfred Maroyi
Lippia javanica occurs naturally in central, eastern, and southern Africa and has also been recorded in the tropical Indian subcontinent. The potential of L. javanica as herbal or recreational tea and herbal medicine and its associated phytochemistry and biological properties are reviewed. The extensive literature survey revealed that L. javanica is used as herbal tea and has ethnomedicinal applications such as in colds, cough, fever, malaria, wounds, diarrhoea, chest pains, bronchitis, and asthma. Multiple classes of phytochemicals including volatile and nonvolatile secondary metabolites such as alkaloids, amino acids, flavonoids, iridoids, and triterpenes as well as several minerals have been identified from L...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28110985/a-profile-of-indian-health-service-emergency-departments
#17
Kenneth Bernard, Kohei Hasegawa, Ashley Sullivan, Carlos Camargo
STUDY OBJECTIVE: The Indian Health Service provides health care to eligible American Indians and Alaskan Natives. No published data exist on emergency services offered by this unique health care system. We seek to determine the characteristics and capabilities of Indian Health Service emergency departments (EDs). METHODS: All Indian Health Service EDs were surveyed about demographics and operational characteristics for 2014 with the National Emergency Department Inventory survey (available at http://www...
January 19, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28107845/usage-of-complementary-and-alternative-medicine-a-survey-among-indian-dental-professionals
#18
M Suganya, M Vikneshan, U Swathy
OBJECTIVE: CAM therapies are used along with standard medical care. Though there are various medical evidences to prove the effectiveness of CAM therapies in managing medical problems, the evidence for the dental application are still lacking in India. This could be attributed to the non-availability or the insufficient knowledge regarding the use of CAM in dentistry. Hence it is necessary to obtain the baseline knowledge regarding the use of CAM therapies among dentists. METHOD: Cross sectional questionnaire based survey...
February 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28104972/utilization-study-of-antihypertensives-in-a-south-indian-tertiary-care-teaching-hospital-and-adherence-to-standard-treatment-guidelines
#19
Supratim Datta
AIM: Hypertension represents a major health problem primarily because of its role in contributing to the initiation and progression of major cardiovascular diseases. Concerns pertaining to hypertension and its sequelae can be substantially addressed and consequent burden of disease reduced by early detection and appropriate therapy of elevated blood pressure. This cross-sectional observational study aims at analyzing the utilization pattern of antihypertensives used for the treatment of hypertension at a tertiary care hospital in perspective of standard treatment guidelines...
December 2016: Journal of Basic and Clinical Pharmacy
https://www.readbyqxmd.com/read/28104546/dying-in-intensive-care-units-of-india-commentaries-on-policies-and-position-papers-on-palliative-and-end-of-life-care
#20
REVIEW
Jaydeep Sengupta, Suhita Chopra Chatterjee
PURPOSE: This study critically examines the available policy guidelines on integration of palliative and end-of-life care in Indian intensive care units to appraise their congruence with Indian reality. MATERIALS AND METHODS: Six position statements and guidelines issued by the Indian Society for Critical Care Medicine and the Indian Association of Palliative Care from 2005 till 2015 were examined. The present study reflects upon the recommendations suggested by these texts...
December 24, 2016: Journal of Critical Care
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