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https://www.readbyqxmd.com/read/26793746/mass-spectrometric-detection-of-biomarkers-for-early-assessment-of-intraamniotic-fluid-infection
#1
Consuelo Cháfer-Pericás, Vedran Stefanovic, Ángel Sánchez-Illana, Javier Escobar, María Cernada, Elena Cubells, Antonio Núñez-Ramiro, Sture Andersson, Máximo Vento, Julia Kuligowski
This data article contains information on glutathione sulfonamide (GSA) structural confirmation and purity after synthesis, as well as mass spectrometry acquisition parameters for the determination of GSA and other biomarkers for the early assessment of intraamniotic fluid infection in amniotic fluid samples (Cháfer-Pericás et al., 2015) [1]. GSA standards were synthesized and structural confirmation was carried out employing time-of-flight mass spectrometry (TOF-MS); purity was assessed by high performance liquid chromatography (HPLC) with UV detection...
December 2015: Data in Brief
https://www.readbyqxmd.com/read/26456057/novel-biomarkers-in-amniotic-fluid-for-early-assessment-of-intraamniotic-infection
#2
Consuelo Cháfer-Pericás, Vedran Stefanovic, Ángel Sánchez-Illana, Javier Escobar, María Cernada, Elena Cubells, Antonio Núñez-Ramiro, Sture Andersson, Máximo Vento, Julia Kuligowski
Intra-amniotic infection/inflammation (IAI) is associated with preterm birth, short and long-term adverse clinical outcomes and oxidative stress. The diagnosis of IAI is based on histological and clinical findings; however, often these results are unspecific. Therefore, efforts have been directed towards validating reliable methods for patients lacking overt clinical symptoms. In this study, amniotic fluid (AF) samples were prospectively collected from 23 women grouped into two categories (with or without IAI) following clinical, microbiological and histological criteria...
December 2015: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/26428501/acute-chorioamnionitis-and-funisitis-definition-pathologic-features-and-clinical-significance
#3
REVIEW
Chong Jai Kim, Roberto Romero, Piya Chaemsaithong, Noppadol Chaiyasit, Bo Hyun Yoon, Yeon Mee Kim
Acute inflammatory lesions of the placenta consist of diffuse infiltration of neutrophils at different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and chorionic vasculitis and represent a host response (maternal or fetal) to a chemotactic gradient in the amniotic cavity. While acute chorioamnionitis is evidence of a maternal host response, funisitis and chorionic vasculitis represent fetal inflammatory responses. Intraamniotic infection generally has been considered to be the cause of acute chorioamnionitis and funisitis; however, recent evidence indicates that "sterile" intraamniotic inflammation, which occurs in the absence of demonstrable microorganisms induced by "danger signals," is frequently associated with these lesions...
October 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26408085/outside-in-acute-fetal-systemic-inflammation-in-very-preterm-chronically-catheterized-sheep-fetuses-is-not-driven-by-cells-in-the-fetal-blood
#4
Matthew W Kemp, Timothy J Molloy, Haruo Usuda, Eleanor Woodward, Yuichiro Miura, Matthew S Payne, Demelza J Ireland, Alan H Jobe, Suhas G Kallapur, Sarah J Stock, Owen B Spiller, John P Newnham, Masatoshi Saito
BACKGROUND: The preterm birth syndrome (delivery before 37 weeks gestation) is a major contributor to the global burden of perinatal morbidity and death. The cause of preterm birth is complex, multifactorial, and likely dependent, at least in part, on the gestational age of the fetus. Intrauterine infection is frequent in preterm deliveries that occur at <32 weeks gestation; understanding how the fetus responds to proinflammatory insult will be an important step towards early preterm birth prevention...
February 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26294950/leptotrichia-buccalis-a-novel-cause-of-chorioamnionitis
#5
Marcela C Smid, Sarah K Dotters-Katz, Rongpong Plongla, Kim A Boggess
Intra-amniotic Leptotrichia buccalis has not been previously associated with adverse pregnancy outcome. We report a case of chorioamnionitis and pregnancy loss associated with this primarily oral commensal. We review Leptotrichia buccalis and other oral commensals that have been identified in cases of intraamniotic infection.
April 15, 2015: Infectious Disease Reports
https://www.readbyqxmd.com/read/25993616/cervical-microbiota-in-women-with-preterm-prelabor-rupture-of-membranes
#6
Marian Kacerovsky, Filip Vrbacky, Radka Kutova, Lenka Pliskova, Ctirad Andrys, Ivana Musilova, Ramkumar Menon, Ronald Lamont, Jana Nekvindova
OBJECTIVE: To analyze the cervical microbiota in women with preterm prelabor rupture of membranes (PPROM) by pyrosequencing and to document associations between cervical microbiota, cervical inflammatory response, microbial invasion of the amniotic cavity (MIAC), histological chorioamnionitis, and intraamniotic infection (IAI). STUDY DESIGN: Sixty-one women with singleton pregnancies complicated by PPROM were included in the study. Specimens of cervical and amniotic fluid were collected on admission...
2015: PloS One
https://www.readbyqxmd.com/read/25953932/prevention-and-treatment-strategy-in-pregnant-women-with-group-b-streptococcal-infection
#7
G Tevdorashvili, D Tevdorashvili, M Andghuladze, M Tevdorashvili
Group B streptococcus (GBS; Streptococcus agalactiae) are encapsulated gram-positive cocci belonging to Lancefield group B, that frequently colonizes the human genital and gastrointestinal tracts. It is an important cause of illness in three categories of population: infants, pregnant women, and adults with underlying medical conditions. In pregnant women and postpartum women, GBS is a frequent cause of asymptomatic bacteriuria, urinary tract infection, upper genital tract infection (i.e. intraamniotic infection or chorioamnionitis), postpartum endometritis (8%), pneumonia (2%), puerperal sepsis (2%), and bacteremia without a focal site (31%)...
April 2015: Georgian Medical News
https://www.readbyqxmd.com/read/25775872/the-evaluation-of-the-predictive-value-of-tnf-alpha-concentration-in-maternal-serum-in-the-prediction-of-neonatal-and-maternal-infection
#8
Tomasz Łukaszewski, Krzysztof Drews, Agnieszka Seremak-Mrozikiewicz, Piotr Sieroszewski, Magdalena Barlik, Hubert Wolski, Marzena Wleklak
INTRODUCTION: The consequences of uncomplicated PPROM are serious, and the presence of overt intraamniotic infection (IAI) is associated with a significant increase in both, the maternal and fetal morbidity and mortality rate. TNF-alpha is a cytokine involved in systemic inflammation and plays an important role in modulating the acute phase reaction. AIM: The aim of this study was to evaluate the predictive value of TNF-alpha levels in maternal serum within 6 hours after pprom and in the period of up to 12 hours after delivery in the prediction of neonatal and maternal infection...
January 2015: Ginekologia Polska
https://www.readbyqxmd.com/read/25760552/fluconazole-treatment-of-intrauterine-candida-albicans-infection-in-fetal-sheep
#9
Gunlawadee Maneenil, Matthew S Payne, Paranthaman Senthamarai Kannan, Suhas G Kallapur, Boris W Kramer, John P Newnham, Yuichiro Miura, Alan H Jobe, Matthew W Kemp
BACKGROUND: Intrauterine Candida albicans infection causes severe fetal inflammatory responses and fetal injury in an ovine model. We hypothesized that intra-amniotic antifungal therapy with fluconazole would decrease the adverse fetal effects of intra-amniotic C. albicans in sheep. METHODS: Sheep received an intra-amniotic injection of 10(7) colony-forming units C. albicans. After 2 d, animals were then randomized to: (i) intra-amniotic and fetal intraperitoneal saline with delivery after 24 h (3 d C...
June 2015: Pediatric Research
https://www.readbyqxmd.com/read/25648771/intra-amniotic-pharmacological-blockade-of-inflammatory-signalling-pathways-in-an-ovine-chorioamnionitis-model
#10
COMPARATIVE STUDY
D J Ireland, M W Kemp, Y Miura, M Saito, J P Newnham, J A Keelan
Intrauterine inflammation (IUI) associated with infection is the major cause of preterm birth (PTB) at <32 weeks' gestation and accounts for ∼40% of all spontaneous PTBs. Pharmacological strategies to prevent PTB and improve fetal outcomes will likely require both antimicrobial and anti-inflammatory therapies. Here we investigated the effects of two cytokine-suppressive anti-inflammatory drugs (CSAIDs), compounds that specifically target inflammatory signalling pathways, in an ovine model of lipopolysaccharide (LPS)-induced chorioamnionitis...
May 2015: Molecular Human Reproduction
https://www.readbyqxmd.com/read/25212978/good-prognosis-of-cerclage-in-cases-of-cervical-insufficiency-when-intra-amniotic-inflammation-infection-is-ruled-out
#11
Vicente Jose Diago Almela, Alicia Martinez-Varea, Alfredo Perales-Puchalt, Ricardo Alonso-Diaz, Alfredo Perales
OBJECTIVE: To determine if absence of sub-clinical intra-amniotic inflammation improves the prognosis of rescue cerclage in cases of bulging membranes. METHODS: Cohort study with all women with bulging membranes admitted into our hospital between 2009 and 2013. Patients underwent amniocentesis to quantify amniotic glucose, leukocytes, IL-6 and leukocyte esterase levels and for microbiological culture. All patients without intra-amniotic inflammation or sub-clinical chorioamnionitis were proposed a physical examination-indicated cervical cerclage...
September 2015: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/25155606/maternal-intravenous-administration-of-azithromycin-results-in-significant-fetal-uptake-in-a-sheep-model-of-second-trimester-pregnancy
#12
Matthew W Kemp, Yuichiro Miura, Matthew S Payne, Alan H Jobe, Suhas G Kallapur, Masatoshi Saito, Sarah J Stock, O Brad Spiller, Demelza J Ireland, Nobuo Yaegashi, Michael Clarke, Dorothee Hahne, Jennifer Rodger, Jeffrey A Keelan, John P Newnham
Treatment of intrauterine infection is likely key to preventing a significant proportion of preterm deliveries before 32 weeks of gestation. Azithromycin (AZ) may be an effective antimicrobial in pregnancy; however, few gestation age-approriate data are available to inform the design of AZ-based treatment regimens in early pregnancy. We aimed to determine whether a single intra-amniotic AZ dose or repeated maternal intravenous (i.v.) AZ doses would safely yield therapeutic levels of AZ in an 80-day-gestation (term is 150 days) ovine fetus...
November 2014: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/25051714/-value-of-probiotic-in-reducing-frequency-of-infectious-complications-in-premature-infants
#13
L A Lo Skiavo, N V Gonchar, A N Suvorov, N P Shabalov, S G Grigor'ev
Fifty five premature infants with very low body weight were observed as inpatients to assess effectiveness of the nursing. The standard program of the care included: adequate primary resuscitation, respiratory support (use of surfactant), thermal mode, early provision of nutrients with full or partial parenteral nutrition, antimicrobial therapy and if possible early enteral nutrition. The patients of the main group (n = 29) along with the standard therapy (the volume of the enteral nutrition of 5 ml or more) were treated orally with liquid probiotic based on E...
2014: Antibiotiki i Khimioterapii︠a︡, Antibiotics and Chemoterapy [sic]
https://www.readbyqxmd.com/read/24770272/effect-of-obesity-on-outcomes-in-nulliparous-women-undergoing-balloon-ripening-for-labor-induction
#14
Maliha A Saylawala, Amanda Horton
INTRODUCTION: The objective of this study was to estimate the effect of maternal obesity on delivery outcomes in nulliparous women undergoing mechanical balloon cervical ripening for induction of labor. METHODS: This was a retrospective cohort study of nulliparous women undergoing induction of labor at term using mechanical balloon cervical ripening. Charts were reviewed to identify nulliparous pregnant women with singleton gestation undergoing labor induction at term and requiring balloon cervical ripening...
May 2014: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/24770182/a-novel-double-cerclage-technique-for-emergency-cerclage-in-women-at-high-risk-for-preterm-birth
#15
Robyn T Bilinski, Joseph J Apuzzio, Jesus R Alvarez-Perez
INTRODUCTION: We report on a series of emergency and reinforcing cerclages using a novel double cerclage technique. METHODS: A 5-year prospective cohort study was conducted on pregnant women with cervical insufficiency managed with our novel double cerclage technique. Eligible patients with cervical dilation of 1-4 cm before 24 weeks of gestation and patients with a failed primary cerclage in situ were included and offered repeat reinforcing cerclage. Patients in preterm labor and intraamniotic infection were excluded...
May 2014: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/24632681/intrauterine-candida-albicans-infection-elicits-severe-inflammation-in-fetal-sheep
#16
Matthew S Payne, Matthew W Kemp, Suhas G Kallapur, Paranthaman Senthamarai Kannan, Masatoshi Saito, Yuichiro Miura, John P Newnham, Sarah Stock, Demelza J Ireland, Boris W Kramer, Alan H Jobe
BACKGROUND: Preventing preterm birth and subsequent adverse neonatal sequelae is among the greatest clinical challenges of our time. Recent studies suggest a role for Candida spp. in preterm birth and fetal injury, as a result of their colonization of either the vagina and/or the amniotic cavity. We hypothesized that intraamniotic Candida albicans would cause a vigorous, acute fetal inflammatory response. METHODS: Sheep carrying singleton pregnancies received single intraamniotic injections of either saline (control) or 10(7) colony-forming units C...
June 2014: Pediatric Research
https://www.readbyqxmd.com/read/24589547/repeated-maternal-intramuscular-or-intraamniotic-erythromycin-incompletely-resolves-intrauterine-ureaplasma-parvum-infection-in-a-sheep-model-of-pregnancy
#17
Matthew W Kemp, Yuichiro Miura, Matthew S Payne, Rory Watts, Smruthi Megharaj, Alan H Jobe, Suhas G Kallapur, Masatoshi Saito, O Brad Spiller, Jeffrey A Keelan, John P Newnham
OBJECTIVE: Ureaplasma spp are the most commonly isolated microorganisms in association with preterm birth. Maternal erythromycin administration is a standard treatment for preterm prelabor rupture of membranes. There is little evidence of its effectiveness in eradicating Ureaplasma spp from the intrauterine cavity and fetus. We used a sheep model of intrauterine Ureaplasma spp infection to investigate the efficacy of repeated maternal intramuscular and intraamniotic erythromycin treatment to eradicate such an infection...
August 2014: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/24372427/-management-of-preterm-prelabor-rupture-of-membranes-with-respect-to-the-inflammatory-complications-our-experiences
#18
REVIEW
M Kacerovský, I Musilová
OBJECTIVE: Preterm prelabor rupture of membranes is responsible for approximately one third of all preterm deliveries. The most common complications associated with this pregnancy pathology are microbial invasion of the amniotic cavity, intraamniotic inflammation, intraamniotic infection and histological chorioamnionitis. This article explains these complicatioss and their relation to the optimal management of preterm prelabor rupture of membranes. DESIGN: Overview study...
December 2013: Ceská Gynekologie
https://www.readbyqxmd.com/read/24337316/ureaplasma-parvum-undergoes-selection-in-utero-resulting-in-genetically-diverse-isolates-colonizing-the-chorioamnion-of-fetal-sheep
#19
Samantha J Dando, Ilias Nitsos, Graeme R Polglase, John P Newnham, Alan H Jobe, Christine L Knox
Ureaplasmas are the microorganisms most frequently isolated from the amniotic fluid of pregnant women and can cause chronic intrauterine infections. These tiny bacteria are thought to undergo rapid evolution and exhibit a hypermutatable phenotype; however, little is known about how ureaplasmas respond to selective pressures in utero. Using an ovine model of chronic intraamniotic infection, we investigated if exposure of ureaplasmas to subinhibitory concentrations of erythromycin could induce phenotypic or genetic indicators of macrolide resistance...
February 2014: Biology of Reproduction
https://www.readbyqxmd.com/read/24294756/-intraamniotic-infection-cause-and-satellite-of-preterm-birth
#20
A Masseva, A Dimitrov, B Marinov, A Nikolov, B Frandeva
Intraamniotic infection (IAI), most commonly presented as chorioamniotitis, plays a major role in the pathogenesis of preterm birth (PTB). In this study, we sought for signs of IAI through clinical and laboratory parameters (leukocyte count, CRP concentration and IL-6 in maternal blood), and compared those to the newborns' infectious condition. Using cervical and vaginal secretion cultures, we determined the probable causing agents of IAI. We also followed up the therapeutic effect from the use of corticosteroids, tocolitics and antibiotics for the treatment of PTB...
2013: Akusherstvo i Ginekologii︠a︡
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