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https://www.readbyqxmd.com/read/28432755/mitochondria-and-ageing-role-in-heart-skeletal-muscle-and-adipose-tissue
#1
REVIEW
Kerstin Boengler, Maik Kosiol, Manuel Mayr, Rainer Schulz, Susanne Rohrbach
Age is the most important risk factor for most diseases. Mitochondria play a central role in bioenergetics and metabolism. In addition, several lines of evidence indicate the impact of mitochondria in lifespan determination and ageing. The best-known hypothesis to explain ageing is the free radical theory, which proposes that cells, organs, and organisms age because they accumulate reactive oxygen species (ROS) damage over time. Mitochondria play a central role as the principle source of intracellular ROS, which are mainly formed at the level of complex I and III of the respiratory chain...
April 21, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28432678/anal-metastasis-of-rectal-cancer-adenocarcinoma-of-squamous-cells-a-case-report-and-literature-review
#2
Shun Sasaki, Masahiko Sugiyama, Yu Nakaji, Ryota Nakanishi, Yuichiro Nakashima, Hiroshi Saeki, Eiji Oki, Yoshinao Oda, Yoshihiko Maehara
Anal metastasis of colorectal cancer is very rare and is usually associated with a history of anal disease, including anal fistula, fissure, hemorrhoidectomy, and anastomotic injury. We report a case of rectal cancer with a synchronous anal metastasis consisting of adenocarcinoma of squamous cells without a history of anal disease. A 60-year-old woman had a chief complaint of melena. She had a 1.5-cm anal tumor on the perianal skin, and a Bollman type 2 rectal tumor on the Ra portion was found on colonoscopy...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28432585/patterns-of-care-and-treatment-outcomes-in-older-adults-with-low-grade-glioma-a-50-year-experience
#3
Ryan S Youland, David A Schomas, Paul D Brown, Ian F Parney, Nadia N I Laack
The purpose of this study was to identify changes in presentation, treatment and outcomes of older patients with low-grade glioma (LGG) over the past 50 years. 94 adults aged 55 or older upon diagnosis of a WHO grade II LGG at Mayo Clinic between 1960 and 2011 were included and grouped by those diagnosed before (group I: 1960-1989) and after (group II: 1990-2011) the routine use of post-operative MRI. Median follow-up was 11.4 years. Pathologic diagnoses included astrocytoma in 55%, mixed oligoastrocytoma in 18% and oligodendroglioma in 27%...
April 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28432461/laparoscopic-surgery-for-t4-colon-cancer-a-systematic-review-and-meta-analysis
#4
Charlotte E L Klaver, Tijmen M Kappen, Wernard A A Borstlap, Willem A Bemelman, Pieter J Tanis
BACKGROUND: In colon cancer, T4 stage is still assumed to be a relative contraindication for laparoscopic surgery considering the oncological safety. The aim of this systematic review with meta-analysis was to evaluate short- and long-term oncological outcomes after laparoscopic surgery for T4 colon cancer, and to compare these with open surgery. METHODS: Using systematic review of literature, studies reporting on radicality of resection, disease-free survival (DFS), and/or overall survival (OS) after laparoscopic surgery for T4 colon cancer were identified, with or without a control group of open surgery...
April 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28432281/the-role-of-non-thermal-atmospheric-pressure-biocompatible-plasma-in-the-differentiation-of-osteoblastic-precursor-cells-mc3t3-e1
#5
Ihn Han, Eun Ha Choi
Non-thermal atmospheric pressure plasma is ionized matter, composed of highly reactive species that include positive ions, negative ions, free radicals, neutral atoms, and molecules. Recent reports have suggested that non-thermal biocompatible plasma (NBP) can selectively kill a variety of cancer cells, and promote stem cell differentiation. However as of yet, the regulation of proliferation and differentiation potential of NBP has been poorly understood.Here, we investigated the effects of NBP on the osteogenic differentiation of precursor cell lines of osteoblasts, MC3T3 E1 and SaOS-2...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28432084/topoisomerase2%C3%AE-and-thymidylate-synthase-expression-in-adrenocortical-cancer
#6
Elisa Roca, Alfredo Berruti, Silviu Sbiera, Ida Rapa, Ester Oneda, Paola Sperone, Cristina L Ronchi, Laura Ferrari, Salvatore Grisanti, Antonina Germano, Barbara Zaggia, Giorgio Scagliotti, Martin Fassnacht, Marco Volante, Massimo Terzolo, Mauro Papotti
Topoisomerase II alpha (TOP2A) and Thymidylate Synthase (TS) are known prognostic parameters in several tumors and also predictors of efficacy of anthracyclines, topoisomerase inhibitors and fluoropirimidines, respectively. Expression of TOP2A and TS mRNA was assessed in 98 patients with adrenocortical carcinoma (ACC) and protein expression was assessed by immunohistochemistry in a subset of 39 tumors. Ninety-two patients were radically resected for stage II-III disease and 38 of them received adjuvant mitotane...
April 21, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28431473/structures-and-bioactivities-of-seven-flavonoids-from-osmanthus-fragrans-jinqiu-essential-oil-extraction-residues
#7
Jiang-Lian Zhou, Xian-Ying Fang, Jing-Qiu Wang, Lin-Guo Zhao, Yi Li, Feng Tang, Yong-De Yue
Osmanthus fragrans are well-known for their fragrance, but it is wasteful if to discard O. fragrans flower after extracting their essential oils. In this paper, we found that O. fragrans flower residues were rich in flavonoids. Six flavonoids and one phenylethanoid glycoside were isolated from the ethanol extract of O. fragrans flower residues, identified as quercetin (1), rutin (2), verbascoside (3), genistin (4), kaempferol (5), isorhamnetin (6) and naringin (7). In bioactivity study, kaempferol (IC50 = 1...
April 21, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28431258/cage-and-linear-structured-polysiloxane-epoxy-hybrids-for-coatings-surface-property-and-film-permeability
#8
Yanli Ma, Ling He, Mengjun Jia, Lingru Zhao, Yanyan Zuo, Pingan Hu
Three polysiloxane/epoxy hybrids obtained by evolving cage- or linear-structured polysiloxane into poly glycidyl methacrylate (PGMA) matrix are compared used as coatings. One is the cage-structured hybrid of P(GMA/MA-POSS) copolymer obtained by GMA and methacrylisobutyl polyhedral oligomeric silsesquioxane (MA-POSS) via free radical polymerization, the other two are PGMA/NH2-POSS and PGMA/NH2-PDMS hybrids by cage-structured aminopropyllsobutyl POSS (NH2-POSS) or linear-structured diamino terminated poly(dimethylsiloxane) (NH2-PDMS) to cure PGMA...
April 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28431175/minepath-org-a-free-interactive-pathway-analysis-web-server
#9
Lefteris Koumakis, Panos Roussos, George Potamias
Minepath (www.minepath.org) is a web-based platform that elaborates on, and radically extends the identification of differentially expressed sub-paths in molecular pathways. Besides the network topology, the underlying MinePath algorithmic processes exploit exact gene-gene molecular relationships (e.g. activation, inhibition) and are able to identify differentially expressed pathway parts. Each pathway is decomposed into all its constituent sub-paths, which in turn are matched with corresponding gene expression profiles...
April 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28430661/the-role-of-postoperative-radiotherapy-port-in-combined-small-cell-lung-cancer-c-sclc
#10
Yu Men, Yang Luo, Yirui Zhai, Jun Liang, Qinfu Feng, Dongfu Chen, Zefen Xiao, Zongmei Zhou, Zhouguang Hui, Luhua Wang
PURPOSE: To explore the value of radiotherapy in C-SCLC patients, especially in those receiving a radical resection. RESULTS: The differences of survivals between the postoperative radiotherapy (PORT) and non-PORT groups were not statistically significant. But analyzing the benefits in subgroups, PORT significantly improved OS (p = 0.015), DFS (p = 0.026), LRFS (p = 0.008) and DMFS (p = 0.030) in stage III patients. For the patients with N2 stage, all survivals of the PORT group were also statistically significantly higher than non-PORT group (p = 0...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430612/diosmetin-exerts-anti-oxidative-anti-inflammatory-and-anti-apoptotic-effects-to-protect-against-endotoxin-induced-acute-hepatic-failure-in-mice
#11
You Yang, Xiao-Bao Gong, Li-Gua Huang, Zhen-Xu Wang, Rong-Zhen Wan, Peng Zhang, Qing-Yan Zhang, Zhu Chen, Bao-Shun Zhang
To investigate the effects and mechanism of diosmetin on acute hepatic failure (AHF), an AHF murine model was established through administration of lipopolysaccharides/D-galactosamine (LPS/D-GalN). In vitro, diosmetin scavenged free radicals. In vivo, diosmetin decreased mortality among mice, blocked the development of histopathological changes and hepatic damage, and suppressed levels of inflammatory mediators and cytokines. In addition, diosmetin prevented the expression of phosphorylated IKK, IκBα, and NF-κB p65 in the NF-κB signaling pathway, and JNK and p38 in the MAPK signaling pathway...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430417/charge-separation-mechanisms-in-ordered-films-of-self-assembled-donor-acceptor-dyad-ribbons
#12
Jenna L Logsdon, Patrick E Hartnett, Jordan N Nelson, Michelle A Harris, Tobin J Marks, Michael R Wasielewski
Orthogonal attachment of polar and nonpolar side-chains to a zinc porphyrin-perylenediimide dyad (ZnP-PDI, 1a) is shown to result in self-assembly of ordered supramolecular ribbons in which the ZnP and PDI molecules form segregated π-stacked columns. Following photoexcitation of the ordered ribbons, ZnP(+•)-PDI(-•) radical ion pairs form in <200 fs and subsequently produce a 30 ± 3% yield of free charge carriers that live for about 100 μs. Elongating the side chains on ZnP and PDI in 1b enhances the order of the films, but does not result in an increase in free charge carrier yield...
April 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28430285/electrochemical-synthesis-of-phosphorus-doped-graphene-quantum-dots-for-free-radical-scavenging
#13
Yan Li, Sen Li, Yingmin Wang, Jun Wang, Hui Liu, Xinqian Liu, Lifeng Wang, Xiaoguang Liu, Wendong Xue, Ning Ma
In this work, phosphorus-doped graphene quantum dots (P-GQDs) with a high phosphorus doping content (>7 at%) are synthesized via an electrochemical approach. Sodium phytate (C6H6Na12O24P6), a green food antioxidant additive, is used as the electrolyte for providing both a phosphorus source and an electrolysis environment. The obtained P-GQDs exhibit excellent scavenging activity of free radicals, such as hydroxyl radicals (˙OH) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). Combined with Raman, FT-IR, and XPS spectral analyses, the reason for high phosphorus content and the mechanism of free radical scavenging of P-GQDs are investigated in our work...
April 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28429417/immobilization-methods-for-the-rapid-total-chemical-synthesis-of-proteins-on-microtiter-plates
#14
Robert Zitterbart, Michael Krumrey, Oliver Seitz
The chemical synthesis of proteins typically involves the solid-phase peptide synthesis of unprotected peptide fragments that are stitched together in solution by native chemical ligation (NCL). The process is slow, and throughput is limited because of the need for repeated high performance liquid chromatography purification steps after both solid-phase peptide synthesis and NCL. With an aim to provide faster access to functional proteins and to accelerate the functional analysis of synthetic proteins by parallelization, we developed a method for the high performance liquid chromatography-free synthesis of proteins on the surface of microtiter plates...
April 21, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28429097/immunomodulatory-and-therapeutic-role-of-cinnamomum-verum-extracts-in-collagen-induced-arthritic-balb-c-mice
#15
Mirza Muhammad Fahd Qadir, Attya Bhatti, Muhammad Usman Ashraf, Mansur Abdullah Sandhu, Sidrah Anjum, Peter John
ETHNOPHARMACOLOGICAL RELEVANCE: Cinnamomum verum (CV), also known as 'Dalchini', is the dry bark of the Cinnamomum verum (L.) plant, and has been used as a traditional Pakistani medicine to alleviate pain and inflammation in patients suffering from arthritic rheumatism. It contains alkaloids, triterpenes, Cinnamaldehyde and other volatile oils. The aim of the present study was to investigate the underlying biological effect of ethyl alcohol (EtOH) and methyl alcohol (MeOH) extracts from CV on collagen type-II induced arthritic (CIA) mice...
April 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28428114/epigenetics-the-third-pillar-of-nitric-oxide-signaling
#16
REVIEW
Samantha Socco, Rhea C Bovee, Marianne B Palczewski, Jason R Hickok, Douglas D Thomas
Nitric oxide (NO), the endogenously produced free radical signaling molecule, is generally thought to function via its interactions with heme-containing proteins, such as soluble guanylyl cyclase (sGC), or by the formation of protein adducts containing nitrogen oxide functional groups (such as S-nitrosothiols, 3-nitrotyrosine, and dinitrosyliron complexes). These two types of interactions result in a multitude of down-stream effects that regulate numerous functions in physiology and disease. Of the numerous purported NO signaling mechanisms, epigenetic regulation has gained considerable interest in recent years...
April 17, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28428001/cholesterol-and-related-sterols-autoxidation
#17
REVIEW
Chiara Zerbinati, Luigi Iuliano
Cholesterol is a unique lipid molecule providing the building block for membranes, hormone, vitamin D and bile acid synthesis. Metabolism of cholesterol involves several enzymes acting on the sterol nucleus or the iso-octyl tail. In the recent years, research interest has been focused on oxysterols, cholesterol derivatives generated by the addition of oxygen to the cholesterol backbone. Oxysterols can be produced enzymatically or by autoxidation. Autoxidation of cholesterol proceeds through type I or type II mechanisms...
April 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28428000/selected-oxidative-stress-biomarkers-in-antenatal-diagnosis-as-11-14-gestational-weeks
#18
Marek Pietryga, Piotr Dydowicz, Kinga Toboła, Marta Napierała, Izabela Miechowicz, Anna Gąsiorowska, Maciej Brązert, Ewa Florek
The primary objective in modern obstetrics and prenatal diagnosis is to predict risks of congenital abnormalities. The aim of the research was to assess the correlation between selected oxidative stress biomarkers with the risk of foetal chromosomal aberration evaluated at the first trimester screening. A series of studies show that balanced free radical activity and oxidative homeostasis are essential for proper bodily growth and function. Reactive oxygen species (ROS) may be one of the factors associated with disruption of cell cycle and tissue development, thus leading to developmental abnormalities...
April 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28427682/effects-and-mechanism-of-diclofenac-degradation-in-aqueous-solution-by-us-zn-0
#19
Ting Huang, Guangming Zhang, Shan Chong, Yucan Liu, Nan Zhang, Shunyan Fang, Jia Zhu
A system of ultrasound radiation coupled with Zn(0) was applied to degrade diclofenac. The effects of initial pH, dosage of Zn(0) and ultrasound density were investigated. To further explore the mechanism of the microcosmic reaction, the fresh and used Zn(0) powders were characterized by SEM, XRD and XPS. Radical scavengers were used to determine the oxidation performance of strong oxidizing free radicals on diclofenac, including hydroxyl radicals and superoxide radicals. The results showed that the optimum removal of diclofenac reached to over 85% at pH of 2...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427673/sonocatalytic-rapid-degradation-of-congo-red-dye-from-aqueous-solution-using-magnetic-fe-0-polyaniline-nanofibers
#20
Raghunath Das, Madhumita Bhaumik, Somnath Giri, Arjun Maity
Nano-sized magnetic Fe(0)/polyaniline (Fe(0)/PANI) nanofibers were used as an effective material for sonocatalytic degradation of organic anionic Congo red (CR) dye. Fe(0)/PANI, was synthesized via reductive deposition of nano-Fe(0) onto the PANI nanofibers at room temperature. Prepared catalyst was characterized using HR-TEM, FE-SEM, XRD, FTIR instruments. The efficacy of catalyst in removing CR was assessed colorimetrically using UV-visible spectroscopy under different experimental conditions such as % of Fe(0) loading into the composite material, solution pH, initial concentration of dye, catalyst dosage, temperature and ultrasonic power...
July 2017: Ultrasonics Sonochemistry
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