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https://www.readbyqxmd.com/read/29778019/phoenix-dactylifera-protects-against-oxidative-stress-and-hepatic-injury-induced-by-paracetamol-intoxication-in-rats
#1
Gamal A Salem, Ahmed Shaban, Hussain A Diab, Wesam A Elsaghayer, Manal D Mjedib, Aomassad M Hnesh, Ravi P Sahu
The current studies were sought to determine effects of antioxidant potential of aqueous and methanolic extracts of Phoenix dactylifera leaves (PLAE and PLME) against the widely-used analgesic paracetamol (PCM) induced hepatotoxicity. Groups of rats were treated with or without PCM (1500 mg/kg), PLAE and PLME (300 mg/kg) and n-acetylcysteine (NAC, 50 mg/kg) followed by assessments of liver function tests, oxidative stress, antioxidant defenses, and hepatotoxicity. We observed that PCM significantly elevated serum liver markers, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and bilirubin compared to control (untreated) group...
May 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29777453/peri-operative-blood-transfusion-does-not-influence-overall-and-disease-free-survival-after-radical-gastrectomy-for-stage-ii-iii-gastric-cancer-a-propensity-score-matching-analysis
#2
Hua Xiao, Wu Liu, Hu Quan, Yongzhong Ouyang
OBJECTIVE: Whether peri-operative blood transfusions (BTF) negatively impact long-term survival after gastrectomy for gastric cancer (GC) remains controversial. The aim of this retrospective study was to investigate independent predictive factors of BTF and the potential impact of BTF on overall survival (OS) and disease-free survival (DFS) in patients who underwent radical gastrectomy for stage II/III GC. METHODS: Of 1020 patients who underwent gastrectomy for stage II/III GC from November 2010 to December 2015, 231 (22...
May 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29775710/dual-ph-sensitive-supramolecular-micelles-from-star-shaped-pdmaema-based-on-%C3%AE-cyclodextrin-for-drug-release
#3
Zaishuai Zhou, Feng Guo, Nairong Wang, Meng Meng, Guiying Li
Star-shaped poly(2-(dimethylamino)ethyl methacrylate) based on β-cyclodextrin (β-CD-(PDMAEMA)7 ) was synthesized by means of atomic transfer radical polymerization (ATRP). Dual pH-sensitive supramolecular micelles were formed from β-CD-(PDMAEMA)7 and benzimidazole modified poly(ε-caprolactone) (BM-PCL) through the host-guest interactions between β-CD and benzimidazole. The supramolecular micelles have regular spherical structure with hydrophobic β-CD/BM-PCL as the core and pH-sensitive PDMAEMA as the shell...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29775063/copper-catalyzed-selective-1-2-dialkylation-of-n-heteroarenes-via-a-radical-addition-reduction-process-application-for-the-construction-of-alkylated-dihydroazaarenes-derivatives
#4
Qiu Sun, Yuan-Yuan Zhang, Jing Sun, Ying Han, Xiaodong Jia, Chao-Guo Yan
A highly efficient Cu-catalyzed 1,2-difunctionalization of various N-heteroarenes were developed with ether and alkyl hal-ide at ambient temperature. This transformation involves the combination of oxidative coupling by Cu/TBHP and reduc-tion process by DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). This method provides an efficient way to prepare various substituted dihydroazaarenes derivatives via a free-radical process.
May 18, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29774505/mitigating-peroxynitrite-mediated-mitochondrial-dysfunction-in-aged-rat-brain-by-mitochondria-targeted-antioxidant-mitoq
#5
Arpan Kumar Maiti, B C Spoorthi, Nimai Chandra Saha, Ashis Kumar Panigrahi
Although reactive oxygen species mediated oxidative stress is a well-documented mechanism of aging, recent evidences indicate involvement of nitrosative stress in the same. As mitochondrial dysfunction is considered as one of the primary features of aging, the present study was designed to understand the involvement of nitrosative stress by studying the impact of a mitochondria-targeted antioxidant MitoQ, a peroxynitrite (ONOO- ) scavenger, on mitochondrial functions. Four groups of rats were included in this study: Group I: Young-6 months (-MitoQ), Group II: Aged-22 months (- MitoQ), Group III: Young-6 months (+ MitoQ), Group IV: Aged-22 months (+ MitoQ)...
May 17, 2018: Biogerontology
https://www.readbyqxmd.com/read/29774145/evaluation-of-attenuative-effect-of-tert-butylhydroquinone-against-diazinon-induced-oxidative-stress-on-hematological-indices-in-male-wistar-rats
#6
Saman Sargazi, Hamidreza Galavi, Sadegh Zarei
Diazinon is an organophosphate toxicant that has been identified to induce oxidative stress within biological systems through altering biochemical and hematological indices, by generating free radicals while deteriorating the cellular antioxidant defense system. The present study was designed to evaluate the effectiveness of tert-butylhydroquinone (TBHQ), a synthetic food additive, in serving as an antioxidant against sub-lethal diazinon-induced oxidative stress in male Wistar rats. Animals were randomly divided into 4 groups: Control (treated with corn oil as a vehicle), diazinon (10 mg/kg/day), TBHQ (0...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29773789/light-induced-formation-of-partially-reduced-oxygen-species-limits-the-lifetime-of-photosystem-1-based-biocathodes
#7
Fangyuan Zhao, Steffen Hardt, Volker Hartmann, Huijie Zhang, Marc M Nowaczyk, Matthias Rögner, Nicolas Plumeré, Wolfgang Schuhmann, Felipe Conzuelo
Interfacing photosynthetic proteins specifically photosystem 1 (PS1) with electrodes enables light-induced charge separation processes for powering semiartificial photobiodevices with, however, limited long-term stability. Here, we present the in-depth evaluation of a PS1/Os-complex-modified redox polymer-based biocathode by means of scanning photoelectrochemical microscopy. Focalized local illumination of the bioelectrode and concomitant collection of H2 O2 at the closely positioned microelectrode provide evidence for the formation of partially reduced oxygen species under light conditions...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29773787/iodine-catalyzed-diazo-activation-to-access-radical-reactivity
#8
Pan Li, Jingjing Zhao, Lijun Shi, Jin Wang, Xiaodong Shi, Fuwei Li
Transition-metal-catalyzed diazo activation is a classical way to generate metal carbene, which are valuable intermediates in synthetic organic chemistry. An alternative iodine-catalyzed diazo activation is disclosed herein under either photo-initiated or thermal-initiated conditions, which represents an approach to enable carbene radical reactivity. This metal-free diazo activation strategy were successfully applied into olefin cyclopropanation and epoxidation, and applying this method to pyrrole synthesis under thermal-initiated conditions further demonstrates the unique reactivity using this method over typical metal-catalyzed conditions...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29773477/selenium-bioaccumulation-and-associated-nutraceutical-properties-in-calocybe-indica-mushroom-cultivated-on-se-enriched-wheat-straw
#9
Himanshi Rathore, Abhishek Sharma, Shalinee Prasad, Satyawati Sharma
Calocybe indica was cultivated on wheat straw enriched with various concentrations of sodium selenite (Na2 SeO3 ), (2.5-40 μg/ml). The content of selenium (Se) in fruit bodies increased linearly by increasing the amount of Na2 SeO3 , although the biomass yield inhibited above 5 μg/ml. The fruit bodies accumulated inorganic Se into organic forms by integrating the Se into proteins (56%-68%), polysaccharides (22%-29%), and nucleic acids (1.4%-2.7%). Maximum protein content (25.31 g/100 g) was observed in fruit bodies harvested from the substrate enriched with 10 μg/ml Se...
May 15, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29773377/mechanically-viscoelastic-nanoreinforced-hybrid-hydrogels-composed-of-polyacrylamide-sodium-carboxymethylcellulose-graphene-oxide-and-cellulose-nanocrystals
#10
Anuj Kumar, Kummara Madhusudana Rao, Sung Soo Han
Polyacrylamide-sodium carboxymethylcellulose (PMC) hybrid hydrogels reinforced with graphene oxide (GO) and/or cellulose nanocrystals (CNCs) were prepared via in situ free-radical polymerization. In this work, GO nanosheets were freshly synthesized by modified Hummer's method alongwith the aqueous suspension of CNCs by acid-hydrolysis. In addition, the effect of GO content (1.5 wt%) and CNCs (from 2.5 wt% to 10.0 wt%) was investigated in these quaternary hydrogels. The results showed good pseudo-plastic behavior, self-healing ability, mechanical performance, and shape-recovery behavior of the hybrid hydrogels reinforced with GO and CNCs content...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773364/homogeneous-synthesis-of-cellulose-acrylate-g-poly-n-alkyl-acrylate-solid-solid-phase-change-materials-via-free-radical-polymerization
#11
Yong-Qiang Qian, Na Han, Yi-Wen Bo, Lin-Li Tan, Long-Fei Zhang, Xing-Xiang Zhang
A novel solid-solid phase change materials, namely, cellulose acrylate-g-poly (n-alkyl acrylate) (CA-g-PAn) (n = 14, 16 and 18) were successfully synthesized by free radical polymerization in N, N-dimethylacetamide (DMAc). The successful grafting was confirmed by fourier transform infrared spectra (FT-IR) and nuclear magnetic resonance (NMR). The properties of the CA-g-PAn copolymers were investigated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA). The phase change temperatures and the melting enthalpies of CA-g-PAn copolymers are in the range of 10...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773167/optimal-dosage-and-early-intervention-of-l-ascorbic-acid-inhibiting-k-2-cr-2-o-7-induced-renal-tubular-cell-damage
#12
Tzeng-Jih Lin, Yeou-Lih Huang, Jung-San Chang, Kuan-Ting Liu, Meng-Chi Yen, Fen-Wei Chen, Yueh-Lun Shih, Jo-Chi Jao, Po-Chi Huang, I-Jeng Yeh
Chromium poisoning can cause renal failure and death. Chromium intoxication may be managed using L-ascorbic acid (vitamin C) therapy. However, the evidence supporting the effectiveness of this treatment is insufficient, and the mechanism of action has not been clarified in renal cells. In this study, our results showed that the optimal regimen of L-ascorbic acid therapy in human epithelial renal proximal tubule cells, HK-2 cells, was 30 μg/mL. Supplementation of L-ascorbic acid with 30 μg/mL and within 8 h of chromium intoxication (K2 Cr2 O7, Cr6+ ) was effective to inhibit renal tubular cell damage by blocking generation of free radicals, cell apoptosis, and autophagy...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29772777/oxidative-stress-in-preeclampsia-and-placental-diseases
#13
REVIEW
Rajaa Aouache, Louise Biquard, Daniel Vaiman, Francisco Miralles
Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At the cellular level, preeclampsia has largely been associated with the release of free radicals by the placenta. Placenta-borne oxidative and nitrosative stresses are even sometimes considered as the major molecular determinants of the maternal disease. In this review, we present the recent literature evaluating free radical production in both normal and pathological placentas (including preeclampsia and other major pregnancy diseases), in humans and animal models...
May 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29772765/protein-carbamylation-a-marker-reflecting-increased-age-related-cell-oxidation
#14
Julia Carracedo, Rafael Ramírez-Carracedo, Irene Martínez de Toda, Carmen Vida, Matilde Alique, Mónica De la Fuente, Rafael Ramírez-Chamond
Carbamylation is a post-translational modification of proteins that may partake in the oxidative stress-associated cell damage, and its increment has been recently proposed as a "hallmark of aging". The molecular mechanisms associated with aging are related to an increased release of free radicals. We have studied whether carbamylated proteins from the peripheral blood of healthy subjects are related to oxidative damage and aging, taking into account the gender and the immune profile of the subjects...
May 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29772758/antioxidant-capacity-of-rigenase-%C3%A2-a-specific-aqueous-extract-of-triticum-vulgare
#15
Immacolata Antonucci, Gabriella Fiorentino, Patrizia Contursi, Massimiliano Minale, Rodolfo Riccio, Salvatore Riccio, Danila Limauro
Reactive species of oxygen (ROS), responsible for oxidative stress, accumulate in various tissues damaged by burns, decubitus ulcers, and vascular lesions. Antioxidants play an important and well-documented role in healing of chronic and acute wounds. Rigenase® , a specific extract of Triticum vulgare manufactured by Farmaceutici Damor, is employed in products used for the regeneration of tissue injuries. In this work, we show that Rigenase® exhibits a scavenging effect toward free radicals, thus pointing to its relevant antioxidant activity...
May 17, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29772693/facile-synthesis-of-magnetic-photocatalyst-ag-bivo%C3%A2-mn-1-x-zn-x-fe%C3%A2-o%C3%A2-and-its-highly-visible-light-driven-photocatalytic-activity
#16
Taiping Xie, Hui Li, Chenglun Liu, Longjun Xu
Ag/BiVO₄/Mn1-x Znx Fe₂O₄ was synthesized with a dip-calcination in situ synthesis method. This work was hoped to provide a simple method to synthesis three-phase composite. The phase structure, optical properties and magnetic feature were confirmed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectrometer (XPS), transmission electron microscopy (TEM), ultraviolet-visible diffuse reflectance spectrophotometer (UV-vis DRS), and vibrating sample magnetometer (VSM)...
May 16, 2018: Materials
https://www.readbyqxmd.com/read/29772689/fabrication-and-characterization-of-nanoenergetic-hollow-spherical-hexanitrostibene-hns-derivatives
#17
Xiong Cao, Peng Deng, Shuangqi Hu, Lijun Ren, Xiaoxia Li, Peng Xiao, Yu Liu
The spherization of nanoenergetic materials is the best way to improve the sensitivity and increase loading densities and detonation properties for weapons and ammunition, but the preparation of spherical nanoenergetic materials with high regularization, uniform size and monodispersity is still a challenge. In this paper, nanoenergetic hollow spherical hexanitrostibene (HNS) derivatives were fabricated via a one-pot copolymerization strategy, which is based on the reaction of HNS and piperazine in acetonitrile solution...
May 16, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29772679/antioxidant-and-ace-inhibitory-activity-of-enzymatic-hydrolysates-from-ruditapes-philippinarum
#18
Yue Yu, Fengjiao Fan, Di Wu, Cuiping Yu, Zhenyu Wang, Ming Du
Ruditapes philippinarum proteins were hydrolyzed by trypsin, neutrase, and pepsin. The antioxidant activities and ACE inhibitory activity of hydrolysates were analyzed and the antioxidant activities were related to their molecular weight distribution and amino acid compositions. Results indicated the hydrolysis of proteins led to an increase in small peptides and free amino acids. The antioxidant activities of Ruditapes philippinarum hydrolysates against DPPH radical scavenging, inhibition on linoleic acid peroxidation, and reducing power showed that the neutrase hydrolysate exhibited the strongest antioxidant activity...
May 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29772322/free-omental-flap-for-tissue-defect-coverage-after-resection-of-complicated-venous-malformation-in-the-area-of-the-knee
#19
Nicla Settembre, Mario D'Oria, Lucie DekerlE, Charbel Saba, Zakariyae Bouziane, Serguei Malikov
Venous malformations are the most common slow-flow vascular malformations; they are not prone to volume decrease over time and invasive treatment is usually required. There are two main techniques to address the definitive therapy of these lesions: sclerotherapy and surgical excision, each with its own advantages and disadvantages. We report the case of a 56 year-old man who came to our attention with persistent pain after multiple unsuccessful attempts to treat a large venous malformation located in the area of the right knee...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29772225/maternal-one-carbon-metabolism-through-increased-oxidative-stress-and-disturbed-angiogenesis-can-influence-placental-apoptosis-in-preeclampsia
#20
REVIEW
Vaishali V Kasture, Deepali P Sundrani, Sadhana R Joshi
Adequate maternal nutrition is critical for a healthy pregnancy outcome and poor maternal nutrition is known to be associated with pregnancy complications like preeclampsia. We have earlier demonstrated that there is an imbalance in the levels of micronutrients (folate and vitamin B12 ) along with low levels of long chain polyunsaturated fatty acids (LCPUFA) and high homocysteine levels in women with preeclampsia. Homocysteine is known to be involved in the formation of free radicals leading to increased oxidative stress...
May 14, 2018: Life Sciences
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