keyword
MENU ▼
Read by QxMD icon Read
search

CTC

keyword
https://www.readbyqxmd.com/read/28333541/extracolonic-findings-at-screening-ct-colonography-prevalence-benefits-challenges-and-opportunities
#1
B Dustin Pooler, David H Kim, Perry J Pickhardt
OBJECTIVE: Extracolonic findings at screening CT colonography (CTC) represent imaging findings incidentally detected outside the colon and rectum. Confusion regarding rates reported in the literature fuels controversy over the relative benefits versus harms of extracolonic findings. CONCLUSION: From an evidence-based approach, this article reviews the prevalence and benefits of and challenges raised by extracolonic findings, as well as opportunities to further leverage the effect of screening CTC...
March 23, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28333072/detection-of-circulating-tumor-cells-using-negative-enrichment-immunofluorescence-and-an-in-situ-hybridization-system-in-pancreatic-cancer
#2
Yu Xu, Tai Qin, Jing Li, Xiuchao Wang, Chuntao Gao, Chao Xu, Jihui Hao, Jingcheng Liu, Song Gao, He Ren
Pancreatic cancer (PC) is the most lethal type of gastrointestinal cancer, and early detection and monitoring is an urgent problem. Circulating tumor cells (CTCs) are emerging as a non-invasive biomarker for tumor detection. However, the low sensitivity is a main problem in the traditional CellSearch System for detecting CTCs, especially in patients with PC. In this study, we used negative enrichment (NE), immunofluorescence and in situ hybridization (FISH) of chromosome 8 (NE-iFISH) to capture and identify CTCs in PC patients...
March 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28332571/profiling-protein-expression-in-circulating-tumour-cells-using-microfluidic-western-blotting
#3
Elly Sinkala, Elodie Sollier-Christen, Corinne Renier, Elisabet Rosàs-Canyelles, James Che, Kyra Heirich, Todd A Duncombe, Julea Vlassakis, Kevin A Yamauchi, Haiyan Huang, Stefanie S Jeffrey, Amy E Herr
Circulating tumour cells (CTCs) are rare tumour cells found in the circulatory system of certain cancer patients. The clinical and functional significance of CTCs is still under investigation. Protein profiling of CTCs would complement the recent advances in enumeration, transcriptomic and genomic characterization of these rare cells and help define their characteristics. Here we describe a microfluidic western blot for an eight-plex protein panel for individual CTCs derived from estrogen receptor-positive (ER+) breast cancer patients...
March 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28327799/prevalence-and-factors-associated-with-syphilis-in-a-reference-center
#4
Natália Carolina Rodrigues Colombo Gomes, Denise Andrade Pereira Meier, Flávia Meneguetti Pieri, Elaine Alves, Silvia Paulino Ribeiro Albanese, Edvilson Cristiano Lentine, Ricardo Alexandre Arcêncio, Elma Mathias Dessunti
INTRODUCTION: The implementation of the rapid test (RT) for syphilis increases access of vulnerable populations to early diagnosis and treatment, impacting the outcomes of infection. We aimed to assess the prevalence of and factors associated with syphilis in a Center for Testing and Counseling (CTC). METHODS: We conducted a cross-sectional study at a Reference Center for sexually transmitted disease (STD) and acquired immune deficiency syndrome in Londrina, Northern Paraná State, Southern Brazil...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28321147/detection-of-circulating-tumour-cells-in-urothelial-cancers-and-clinical-correlations-comparison-of-two-methods
#5
Emanuela Fina, Andrea Necchi, Stefano Bottelli, Carolina Reduzzi, Sara Pizzamiglio, Chiara Iacona, Maria Grazia Daidone, Paolo Verderio, Vera Cappelletti
Circulating tumour cells (CTC) are identified exploiting their protein/gene expression patterns or distinct size compared to blood cells. Data on CTC in bladder cancer (BC) are still scarce. We comparatively analyzed CTC enrichment by AdnaTest ProstateCancerSelect (AT) and ScreenCell®Cyto (SC) kits, combined with identification by EPCAM, MUC1, and ERBB2 expression and by cytological criteria, respectively, in 19 nonmetastatic (M0) and 47 metastatic (M+) BC patients, at baseline (T0) and during treatment (T1)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28316063/endothelial-long-non-coding-rnas-regulated-by-oxidized-ldl
#6
Krishna K Singh, Pratiek N Matkar, Yi Pan, Adrian Quan, Vijay Gupta, Hwee Teoh, Mohammed Al-Omran, Subodh Verma
Oxidized low-density lipoprotein (oxLDL) plays a central role in the pathogenesis of atherosclerosis, in part via an effect to promote endothelial dysfunction. In the present study, we evaluated the expression profiles of long non-coding RNAs (lncRNAs) and protein-coding mRNAs in endothelial cells following oxLDL stimulation. LncRNAs and mRNAs from human umbilical vein endothelial cells (HUVECs) were profiled with the Arraystar Human lncRNA Expression Microarray V3.0 following 24 h of oxLDL treatment (100 µg/mL)...
March 18, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28315180/inflammation-based-indexes-and-clinicopathologic-features-are-strong-predictive-values-of-preoperative-circulating-tumor-cell-detection-in-gastric-cancer-patients
#7
L Zheng, K Zou, C Yang, F Chen, T Guo, B Xiong
PURPOSE: Circulating tumor cell (CTC) count and the host inflammatory response are two independent predictors for patients with various malignant disease. Several inflammation-based indicators have been demonstrated to have prognostic value in many malignant solid tumors, including systemic immune-inflammation index (SII), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and prognostic nutrition index (PNI). The aim of this study was to evaluate the predictive value of the inflammation-based indexes including SII, NLR PLR, and PNI for CTC detection of gastric cancer patients before surgery...
March 17, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28314286/safety-and-tolerance-of-d-l-methadone-in-combination-with-chemotherapy-in-patients-with-glioma
#8
Julia Onken, Claudia Friesen, Peter Vajkoczy, Martin Misch
BACKGROUND/AIM: D,L-Methadone increases sensitivity toward chemotherapy of different tumor cell populations. We evaluated the safety and tolerance of additional use of D,L-methadone in patients with glioma in combination with chemotherapy. PATIENTS AND METHODS: The dosage, duration of therapy and side-effects related to D,L-methadone were recorded in 27 patients. Toxicity was assessed accordingly to the Common Toxicity Criteria (CTC) of the National Cancer Institute...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28301753/identification-and-quantitation-of-circulating-tumor-cells
#9
Siddarth Rawal, Yu-Ping Yang, Richard Cote, Ashutosh Agarwal
Circulating tumor cells (CTCs) are shed from the primary tumor into the circulatory system and act as seeds that initiate cancer metastasis to distant sites. CTC enumeration has been shown to have a significant prognostic value as a surrogate marker in various cancers. The widespread clinical utility of CTC tests, however, is still limited due to the inherent rarity and heterogeneity of CTCs, which necessitate robust techniques for their efficient enrichment and detection. Significant recent advances have resulted in technologies with the ability to improve yield and purity of CTC enrichment as well as detection sensitivity...
March 6, 2017: Annual Review of Analytical Chemistry
https://www.readbyqxmd.com/read/28299514/prognostic-and-predictive-value-of-circulating-tumor-cells-and-cxcr4-expression-as-biomarkers-for-a-cxcr4-peptide-antagonist-in-combination-with-carboplatin-etoposide-in-small-cell-lung-cancer-exploratory-analysis-of-a-phase-ii-study
#10
Ravi Salgia, R Waide Weaver, Michael McCleod, John R Stille, S Betty Yan, Stephanie Roberson, John Polzer, Amy Flynt, Eyas Raddad, Victoria L Peek, Sameera R Wijayawardana, Suzane L Um, Steve Gross, Mark C Connelly, Carrie Morano, Madeline Repollet, Renouard Sanders, Kurt Baeten, David D'Haese, David R Spigel
Background Circulating tumor cells (CTCs) and chemokine (C-X-C motif) receptor 4 (CXCR4) expression in CTCs and tumor tissue were evaluated as prognostic or predictive markers of CXCR4 peptide antagonist LY2510924 plus carboplatin-etoposide (CE) versus CE in extensive-stage disease small cell lung cancer (ED-SCLC). Methods This exploratory analysis of a phase II study evaluated CXCR4 expression in baseline tumor tissue and peripheral blood CTCs and in post-treatment CTCs. Optimum cutoff values were determined for CTC counts and CXCR4 expression in tumors and CTCs as predictors of survival outcome...
March 15, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28295408/circulating-tumor-cells-as-a-marker-for-progression-free-survival-in-metastatic-castration-na%C3%A3-ve-prostate-cancer
#11
Andreas Josefsson, Anna Linder, Despina Flondell Site, Giacomo Canesin, Anna Stiehm, Aseem Anand, Anders Bjartell, Jan-Erik Damber, Karin Welén
BACKGROUND: Analysis of circulating tumor cells (CTC) is a promising prognostic marker in castration-resistant prostate cancer (CRPC). The aim of this study was to investigate CTC detection and phenotyping as prognostic biomarkers for response to primary androgen deprivation therapy (ADT) of metastatic prostate cancer (PC). METHODS: PC patients presenting with a prostate specific antigen (PSA) >80 ng/ml and/or metastatic disease, intended for ADT were enrolled in the study...
March 10, 2017: Prostate
https://www.readbyqxmd.com/read/28289866/the-role-of-circulating-tumor-cells-in-evaluation-of-prognosis-and-treatment-response-in-advanced-non-small-cell-lung-cancer
#12
Jia Zhou, Fei Dong, Fang Cui, Rui Xu, Xiaokui Tang
PURPOSE: Non-small-cell lung cancer (NSCLC) lacks validated biomarkers to predict the prognosis and treatment response. This study investigated whether circulating tumor cells (CTCs) detectable could reminder high risk of distant metastasis, provide prognostic information, and early indicate the response to the conventional therapy in patients with advanced NSCLC. PATIENTS AND METHODS: In this single-center prospective study, blood samples for CTC analysis were obtained from 59 patients with previously untreated, stage III or IV NSCLC both before and after administration of two cycles of chemotherapy...
March 13, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28286287/incidence-of-capecitabine-related-cardiotoxicity-in-different-treatment-schedules-of-metastatic-colorectal-cancer-a-retrospective-analysis-of-the-cairo-studies-of-the-dutch-colorectal-cancer-group
#13
Johannes J M Kwakman, Lieke H J Simkens, Linda Mol, Wouter E M Kok, Miriam Koopman, Cornelis J A Punt
BACKGROUND: The frequency of capecitabine-related cardiotoxicity has been reported to be low but includes serious adverse events. We conducted a retrospective analysis of the incidence and severity of capecitabine-related cardiotoxicity in different regimens in the treatment of metastatic colorectal cancer in three randomised phase 3 studies. METHODS: We used data of cardiac events reported in the CAIRO, CAIRO2 and CAIRO3 studies of the Dutch Colorectal Cancer Group (DCCG) and analysed the incidence and severity of cardiac events in the different treatment regimens of the trials which all included the use of capecitabine...
March 9, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28285199/nanosphere-based-one-step-strategy-for-efficient-and-nondestructive-detection-of-circulating-tumor-cells
#14
Ling-Ling Wu, Cong-Ying Wen, Jiao Hu, Man Tang, Chu-Bo Qi, Na Li, Cui Liu, Lan Chen, Dai-Wen Pang, Zhi-Ling Zhang
Detecting viable circulating tumor cells (CTCs) without disruption to their functions for in vitro culture and functional study could unravel the biology of metastasis and promote the development of personalized anti-tumor therapies. However, existing CTC detection approaches commonly include CTC isolation and subsequent destructive identification, which damages CTC viability and functions and generates substantial CTC loss. To address the challenge of efficiently detecting viable CTCs for functional study, we develop a nanosphere-based cell-friendly one-step strategy...
March 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28274569/predictive-value-of-circulating-tumor-cells-ctcs-captured-by-microfluidic-device-in-patients-with-epithelial-ovarian-cancer
#15
Maria Lee, Eun Jae Kim, Youngnam Cho, Sunshin Kim, Hyun Hoon Chung, Noh Hyun Park, Yong-Sang Song
OBJECTIVE: To test an electrically conductive chip, incorporating a nanoroughened microfluidic platform for the capture of circulating tumor cells (CTCs), and assess its clinical merit in instances of epithelial ovarian cancer (EOC). METHODS: A total of 54 patients with EOC recruited between August 2014 and May 2015 were enrolled in this prospective study. CTCs in peripheral blood were detected in advance of primary tumor resection and before initiating adjuvant chemotherapy for recurrent disease...
March 5, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28271383/global-protein-expression-profile-response-of-planktonic-aeromonas-hydrophila-exposed-to-chlortetracycline
#16
Wanxin Li, Zujie Yao, Xiangyu Zhang, Fang Huang, Wenxiong Lin, Xiangmin Lin
The antibiotics resistance phenomena of Aeromonas hydrophila has become serious economic and public health problems for the world aquaculture industry and human health care. In this study, to investigate the instinct antibiotics adaptive mechanism of this pathogen, iTRAQ (Isobaric Tags for Relative and Absolute Quantitation) based quantitative proteomics technologies were performed to compare the differential expression of A. hydrophila in planktonic status in response to chlortetracycline (CTC) stress and then identified total 1552 proteins including 285 altered proteins with 90 increasing and 195 decreasing abundance proteins...
April 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28271309/mutational-studies-on-single-circulating-tumor-cells-isolated-from-the-blood-of-inflammatory-breast-cancer-patients
#17
Catherine Bingham, Sandra V Fernandez, Patricia Fittipaldi, Paul W Dempsey, Karen J Ruth, Massimo Cristofanilli, R Katherine Alpaugh
PURPOSE: The molecular characterization of circulating tumor cells (CTCs) is critical to identify the key drivers of cancer metastasis and devising therapeutic approaches, particularly for inflammatory breast cancer (IBC) which is usually diagnosed at advance stages and progresses rapidly. METHODS: Genomic alterations in tumor tissue samples were studied using Foundation One™. Single CTCs were isolated using CellSearch followed by single-cell isolation by DEPArray™...
March 7, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28270290/application-of-low-tube-voltage-70-kv-and-advanced-modeled-iterative-reconstruction-in-the-third-generation-dual-source-ct-to-ct-colonography
#18
Jingjuan Liu, Weidong Pan, Huadan Xue, Bin Li, Xuan Wang, Hao Sun, Yun Wang, Wei Liu, Zhengyu Jin
Objective To explore the feasibility of reducing radiation dose of CT colonography (CTC) while preserving image quality using the third-generation dual-source CT at 70 kV tube voltage with advanced modeled iterative reconstruction (ADMIRE). Methods This prospective study consecutively included 53 patients. All patients underwent CTC at 120 kV in supine position with filtered back projection reconstruction and at 70 kV in prone position with ADMIRE with the same scan range. Radiation dose and image quality were compared between these two protocols...
February 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28262832/data-driven-discovery-of-extravasation-pathway-in-circulating-tumor-cells
#19
S Yadavalli, S Jayaram, S S Manda, A K Madugundu, D S Nayakanti, T Z Tan, R Bhat, A Rangarajan, A Chatterjee, H Gowda, J P Thiery, P Kumar
Circulating tumor cells (CTCs) play a crucial role in cancer dissemination and provide a promising source of blood-based markers. Understanding the spectrum of transcriptional profiles of CTCs and their corresponding regulatory mechanisms will allow for a more robust analysis of CTC phenotypes. The current challenge in CTC research is the acquisition of useful clinical information from the multitude of high-throughput studies. To gain a deeper understanding of CTC heterogeneity and identify genes, pathways and processes that are consistently affected across tumors, we mined the literature for gene expression profiles in CTCs...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28262378/emissions-estimates-of-carbon-tetrachloride-for-1992-2014-in-china
#20
Pengju Bie, Xuekun Fang, Zhifang Li, Ziyuan Wang, Jianxin Hu
Discrepancies in emission estimates of carbon tetrachloride (CCl4, CTC), between bottom-up and top-down methods, have been shown since the 1990s at both the global and regional scale. This study estimates the emissions of China from 1992 to 2014 based on emission functions and aggregated activity information given reasonable uncertainties. The results show that emissions increase from 7.3 Gg/yr (5.6-9.1 Gg/yr at 95% confidential interval) to 14.0 (9.1-19.5) Gg/yr with a growth rate of 6.7 (1.9-11.4) %/yr during 1992-2002 and then decrease to a minimum of 4...
March 2, 2017: Environmental Pollution
keyword
keyword
17941
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"