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https://www.readbyqxmd.com/read/29780561/triple-action-pt-iv-derivatives-of-cisplatin-a-new-class-of-potent-anticancer-agents-that-overcome-resistance
#1
Emanuele Petruzzella, Roman Sirota, Irene Solazzo, Valentina Gandin, Dan Gibson
A series of triple action Pt(iv) prodrugs was designed to test the hypothesis that multi-action compounds, where each bioactive moiety intervenes in several cellular processes, might be more effective than a single agent at killing cancer cells. In particular, "triple action" Pt(iv) derivatives of cisplatin, where the axial ligands are inhibitors of cyclooxygenase (COXi), histone deacetylase (HDACi) or pyruvate dehydrogenase kinase (PDKi) were developed. All compounds, ctc-[Pt(NH3 )2 (COXi)(PDKi)Cl2 ], ctc-[Pt(NH3 )2 (COXi)(HDACi)Cl2 ] and ctc-[Pt(NH3 )2 (HDACi)(PDKi)Cl2 ], where COXi = aspirin or ibuprofen, PDKi = dichloroacetate and HDACi = valproate or phenylbutyrate, were significantly more cytotoxic than cisplatin against all cell lines of an in-house panel of human cancer cells...
May 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29779327/-comparison-of-the-efficacy-of-decitabine-combined-with-micro-transplantation-or-priming-regimen-as-consolidation-treatment-for-older-patients-with-acute-myeloid-leukemia
#2
W Y Li, Y F Feng, X Ma, H Y Qiu, C C Fu, X W Tang, Y Han, D P Wu, A N Sun
Objective: To probe the feasibility of decitabine (DAC) combined with micro-transplantation as consolidation treatment for older patients with acute myeloid leukemia (AML). Methods: Between November 2012 and September 2015, 37 consecutive patients with AML ≥60 years of age were analyzed. Of them, 19 patients received consolidation therapy with DAC followed by micro-transplantation (microtransplant group). Another 18 ones (chemo group) were treated with DAC plus priming regimen as consolidation chemotherapy in the same period...
April 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29778154/effects-of-chlortetracycline-cu-and-their-combination-on-the-performance-and-microbial-community-dynamics-in-swine-manure-anaerobic-digestion
#3
Rui Wang, Junya Zhang, Jibao Liu, Dawei Yu, Hui Zhong, Yawei Wang, Meixue Chen, Juan Tong, Yuansong Wei
Swine manure was typical for the combined pollution of heavy metals and antibiotics. The effects of widely used veterinary antibiotic chlortetracycline (CTC), Cu and their combination on swine manure anaerobic digestion performance and microbial community have never been investigated. Thus, four 2L anaerobic digestion reactors were established including reactor A (control), B (CTC spiked by 0.5g/kg dry weight, dw), C (Cu spiked by 5g/kg dw) and D (combination of CTC, 0.5g/kg dw, and Cu, 5g/kg dw), and dynamics of bacterial and archaeal community structure was investigated using high throughput sequencing method...
May 2018: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29777956/how-do-gender-relations-affect-the-working-lives-of-close-to-community-health-service-providers-empirical-research-a-review-and-conceptual-framework
#4
Rosalind Steege, Miriam Taegtmeyer, Rosalind McCollum, Kate Hawkins, Hermen Ormel, Maryse Kok, Sabina Rashid, Lilian Otiso, Mohsin Sidat, Kingsley Chikaphupha, Daniel Gemechu Datiko, Rukhsana Ahmed, Rachel Tolhurst, Woedem Gomez, Sally Theobald
Close-to-community (CTC) providers have been identified as a key cadre to progress universal health coverage and address inequities in health service provision due to their embedded position within communities. CTC providers both work within, and are subject to, the gender norms at community level but may also have the potential to alter them. This paper synthesises current evidence on gender and CTC providers and the services they deliver. This study uses a two-stage exploratory approach drawing upon qualitative research from the six countries (Bangladesh, Indonesia, Ethiopia, Kenya, Malawi, Mozambique) that were part of the REACHOUT consortium...
May 5, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29773122/cost-effectiveness-of-the-controlled-temperature-chain-for-the-hepatitis-b-virus-birth-dose-vaccine-in-various-global-settings-a-modelling-study
#5
Nick Scott, Anna Palmer, Christopher Morgan, Olufunmilayo Lesi, C Wendy Spearman, Mark Sonderup, Margaret Hellard
BACKGROUND: The controlled temperature chain (CTC) strategy allows vaccines to be kept outside the cold chain for a short period of time. In remote rural areas, the CTC strategy for the hepatitis B virus (HBV) birth dose vaccination could improve its geographical coverage and timeliness of delivery, but with additional outreach costs. We assessed the cost-effectiveness of the CTC strategy for the HBV birth dose across six world regions and 72 countries according to their HBV prevalence, delivery costs, and birth dose coverage and timing...
June 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29770264/calcified-triticeous-cartilage-detected-on-digital-panoramic-radiographs-in-a-sample-of-lebanese-population
#6
Georges Aoun, Ibrahim Nasseh
Objective: Triticeous cartilage is a small ovoid structure belonging to the laryngeal skeleton. When calcified, it becomes visible on panoramic radiographs and be mistaken for a carotid artery calcification (CAC) associated with cerebrovascular accidents. This study aimed to estimate the prevalence of calcified triticeous cartilage (CTC) detected by means of digital panoramic radiographs in a sample of Lebanese population. Materials and Methods: Digital panoramic radiographs of 500 Lebanese adult patients (281 females and 219 males) with a mean age of 47...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29764586/-relationship-between-fgfr1-gene-regulation-of-circulating-tumor-cells-and-clinical-features-of-non-small-cell-lung-cancer
#7
Lei Liu, Cheng Huang, Li Li, Naixin Liang, Shanqing Li
BACKGROUND: The methods of detection for recurrence and metastasis in patients with non-small cell lung cancer (NSCLC) have hysteresis and one-sidedness. This study summarizes the relationship between the circulating tumor cell (CTC) in peripheral blood, expression of fibroblast growth factor receptor 1 (FGFR1) and clinic pathological features in 30 patients with NSCLC so as to provide new ideas for the detection of tumor recurrence and metastasis. METHODS: To analyze the clinical data and CTC detection data of 30 cases of NSCLC in Department of Thoracic Surgery, Peking Union Medical College Hospital from November 2016 to June 2017...
May 20, 2018: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/29762619/isolation-and-genome-sequencing-of-individual-circulating-tumor-cells-using-hydrogel-encapsulation-and-laser-capture-microdissection
#8
Emily S Park, Justin P Yan, Richard A Ang, Jeong Hyun Lee, Xiaoyan Deng, Simon P Duffy, Kevin Beja, Matti Annala, Peter C Black, Kim N Chi, Alexander W Wyatt, Hongshen Ma
Circulating tumor cells (CTCs) are malignant cells released into the bloodstream with the potential to form metastases in secondary sites. These cells, acquired non-invasively, represent a sample of highly relevant tumor tissue that is an alternative to difficult and low-yield tumor biopsies. In recent years, there has been growing interest in genomic profiling of CTCs to enable longitudinal monitoring of the tumor's adaptive response to therapy. However, due to their extreme rarity, genotyping CTCs has proved challenging...
May 15, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29761359/ct-colonography-size-reduction-of-submerged-colorectal-polyps-due-to-electronic-cleansing-and-ct-window-settings
#9
Christian Bräuer, Philippe Lefere, Stefaan Gryspeerdt, Helmut Ringl, Ali Al-Mukhtar, Paul Apfaltrer, Dominik Berzaczy, Barbara Füger, Julia Furtner, Christina Müller-Mang, Matthias Pones, Martina Scharitzer, Ramona Woitek, Anno Graser, Michael Weber, Thomas Mang
OBJECTIVES: To assess whether electronic cleansing (EC) of tagged residue and different computed tomography (CT) windows influence the size of colorectal polyps in CT colonography (CTC). METHODS: A database of 894 colonoscopy-validated CTC datasets of a low-prevalence cohort was retrospectively reviewed to identify patients with polyps ≥6 mm that were entirely submerged in tagged residue. Ten radiologists independently measured the largest diameter of each polyp, two-dimensionally, before and after EC in colon, bone, and soft-tissue-windows, in randomised order...
May 14, 2018: European Radiology
https://www.readbyqxmd.com/read/29759554/the-identification-and-isolation-of-ctcs-a-biological-rubik-s-cube
#10
REVIEW
Cristina Mansilla, Elena Soria, Natalia Ramírez
Liquid biopsy represents an alternative to conventional biopsies for the evaluation of tumors mainly due to its easy sampling. One of the main applications is the enumeration of Circulating Tumor Cells (CTCs) to evaluate tumor progression or response to treatment. The analysis of the functional characteristics of CTCs could give us much more information about their role in order to establish a more personalized treatment for the patients. The major issue that has to be solved is the isolation of the CTC population...
June 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29759193/highly-sensitive-detection-and-mutational-analysis-of-lung-cancer-circulating-tumor-cells-using-integrated-combined-immunomagnetic-beads-with-a-droplet-digital-pcr-chip
#11
Wanlei Gao, Ting Huang, Haojun Yuan, Jun Yang, Qinghui Jin, Chunping Jia, Guoxin Mao, Jianlong Zhao
Circulating tumor cells (CTCs) have become an important biomarker for liquid biopsy to monitor tumor progression and indicate response to therapies. Many epithelial cellular adhesion molecule (EpCAM) dependent CTC isolation methods have been developed, which have a limitation for low EpCAM expressed tumor cells. In an effort to overcome these drawbacks, we developed combined immunomagnetic beads (EpCAM, Mucin1 and epidermal growth factor receptor) to sensitively isolate CTCs for immunofluorescence analysis and genetic characterization...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29753882/circulating-tumor-microemboli-progress-in-molecular-understanding-and-enrichment-technologies
#12
REVIEW
Muhammad Umer, Ramanathan Vaidyanathan, Nam-Trung Nguyen, Muhammad J A Shiddiky
Circulating tumor cells (CTCs) and their clusters, also known as circulating tumor microemboli (CTM), have emerged as valuable tool that can provide mechanistic insights into the tumor heterogeneity, clonal evolution, and stochastic events within the metastatic cascade. However, recent investigations have hinted that CTM may not be mere aggregates of tumor cells but cells comprising CTM exhibit distinct phenotypic and molecular characteristics in comparison to single CTCs. Moreover, in many cases CTM demonstrated higher metastatic potential and resistance to apoptosis as compared to their single cell counterparts...
May 10, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29752570/polyethyleneimine-capped-bimetallic-au-pt-nanoclusters-are-a-viable-fluorescent-probe-for-specific-recognition-of-chlortetracycline-among-other-tetracycline-antibiotics
#13
Na Xu, Lei Meng, Hong-Wei Li, Da-Yong Lu, Yuqing Wu
A highly selective method has been developed for the fluorometric determination of chlortetracycline (CTC) among other tetracycline antibiotics (TCs). It is making use of fluorescent Au/Pt nanoclusters (NCs) capped with polyethyleneimine (Au/PtNCs@PEI). The nanoprobe, with a green emission peaking at 512 nm, was synthesized by an environmentally friendly hydrothermal method. The capped NCs have a large Stokes shift (∼150 nm), are insensitive to extreme pH values and high ionic strength, and are excellently photostable under UV irradiation...
May 11, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29748004/pd-l1-expression-in-circulating-tumor-cells-of-advanced-non-small-cell-lung-cancer-patients-treated-with-nivolumab
#14
Nicolas Guibert, Myriam Delaunay, Amélie Lusque, Nadia Boubekeur, Isabelle Rouquette, Estelle Clermont, Jean Mourlanette, Sandrine Gouin, Inge Dormoy, Gilles Favre, Julien Mazieres, Anne Pradines
BACKGROUND: Inhibitors of the PD-1/PD-L1 immune checkpoint have become a standard of care in non-small cell lung cancer (NSCLC). Patient selection, currently based on PD-L1 expression on tumor tissue, is limited by its temporal and spatial heterogeneity. We hypothesized that liquid biopsy with PD-L1 analysis on circulating tumor cells (CTCs) might overcome this limitation. METHODS: Blood samples were prospectively collected from patients with advanced NSCLC before nivolumab treatment and at the time of progression...
June 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29746918/circulating-tumor-cells-in-stage-iv-melanoma-patients
#15
Carolyn S Hall, Merrick Ross, Jessica B Bowman Bauldry, Joshua Upshaw, Mandar G Karhade, Richard Royal, Sapna Patel, Anthony Lucci
BACKGROUND: Management of stage IV melanoma patients remains a challenge. In spite of promising new therapies, many patients develop resistance and progression. The aim of this pilot study was to determine if CTCs are associated with shortened (180-day) progression-free survival (PFS) following a baseline CTC assessment in stage IV melanoma patients. METHODS: A baseline CTC assessment was performed in 93 stage IV melanoma patients using a commercially available immunomagnetic system...
May 7, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29741566/circulating-tumor-cell-increase-as-a-biomarker-of-disease-progression-in-metastatic-castration-resistant-prostate-cancer-patients-with-low-baseline-ctc-counts
#16
D Lorente, D Olmos, J Mateo, D Dolling, D Bianchini, G Seed, P Flohr, M Crespo, I Figueiredo, S Miranda, H I Scher, L W M M Terstappen, J S de Bono
Background: The development of treatment response and surrogate biomarkers for advanced prostate cancer care is an unmet clinical need. Patients with baseline circulating tumor cell counts (BLCTCs)<5/7.5 mL represent a good prognosis subgroup, but are non-evaluable for response assessment (decrease in CTCs). The aim of the study is to determine the value of any increase in CTCs (CTC Progression) as an indicator of progression in prostate cancer patients with low pre-treatment CTCs (<5)...
May 7, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29739347/elevated-serum-ras-p21-is-an-independent-prognostic-factor-in-metastatic-breast-cancer
#17
Malgorzata Banys-Paluchowski, Tanja Fehm, Wolfgang Janni, Bahriye Aktas, Peter A Fasching, Sabine Kasimir-Bauer, Karin Milde-Langosch, Klaus Pantel, Brigitte Rack, Sabine Riethdorf, Erich-Franz Solomayer, Isabell Witzel, Volkmar Müller
BACKGROUND: An important component of the RAS signalling pathway, the RAS p21 oncogene, is frequently hyperactivated in breast cancer. Its expression in tumor tissue has been linked to poor clinical outcome. This study was designed to evaluate the clinical relevance of RAS p21 levels in peripheral blood in a large cohort of metastatic breast cancer patients. METHODS: Two hundred fifty-one patients with metastatic breast cancer were enrolled in this prospective, multicentre, open-label, non-randomized study...
May 8, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29731846/the-clinical-value-of-detecting-circulating-tumour-cells-in-the-peripheral-blood-of-nasopharyngeal-carcinoma-patients
#18
Zhuo Chen, Lu Xu, Xinhua Xu, Chen Yuan
The aim of the present study as to analyse the associations between circulating tumour cells (CTCs) and the clinical parameters of nasopharyngeal carcinoma (NPC). Peripheral blood (7.5 ml) from 68 first-diagnosed NPC patients was collected to detect and identify CTCs by cluster of differentiation (CD)45 immunomagnetic separation. Immunofluorescent staining of cytokeratin-18, CD45 and DAPI, and fluorescence in situ hybridization were combined with the centromere of chromosome 8 (CEP8) probe method to analyse the associations between CTCs and clinical parameters...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29725990/gene-expression-analysis-of-immunomagnetically-enriched-circulating-tumor-cell-fraction-in-castration-resistant-prostate-cancer
#19
Markéta Škereňová, Veronika Mikulová, Otakar Čapoun, David Švec, Katarína Kološtová, Viktor Soukup, Hana Honová, Tomáš Hanuš, Tomáš Zima
BACKGROUND: Molecular characterization of tumors could be a key to therapeutic decision-making with regards to targeted therapies in castration-resistant prostate cancer (CRPC). A convenient solution may be non-invasive liquid biopsy testing of circulating tumor cells (CTCs). For this reason, CTC-enriched samples obtained by immunomagnetic separation (AdnaTest® ) were studied as a source material for high-throughput gene expression analysis using BioMark™. PATIENTS AND METHODS: CTC-enriched samples from 41 CRPC patients previously determined to be CTC positive using the AdnaTest® were retrospectively re-analysed for androgen receptor (AR) messenger RNA (mRNA), using the updated AdnaTest® ...
May 3, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29721202/circulating-tumor-cells-tumor-derived-extracellular-vesicles-and-plasma-cytokeratins-in-castration-resistant-prostate-cancer-patients
#20
Afroditi Nanou, Frank A W Coumans, Guus van Dalum, Leonie L Zeune, David Dolling, Wendy Onstenk, Mateus Crespo, Mariane Sousa Fontes, Pasquale Rescigno, Gemma Fowler, Penny Flohr, Christoph Brune, Stefan Sleijfer, Johann S de Bono, Leon W M M Terstappen
Purpose: The presence of Circulating Tumor Cells (CTCs) in Castration-Resistant Prostate Cancer (CRPC) patients is associated with poor prognosis. In this study, we evaluated the association of clinical outcome in 129 CRPC patients with CTCs, tumor-derived Extracellular Vesicles (tdEVs) and plasma levels of total (CK18) and caspase-cleaved cytokeratin 18 (ccCK18). Experimental Design: CTCs and tdEVs were isolated with the CellSearch system and automatically enumerated...
April 10, 2018: Oncotarget
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