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https://www.readbyqxmd.com/read/29298188/sphingosine-kinase-1-regulates-inflammation-and-contributes-to-acute-lung-injury-in-pneumococcal-pneumonia-via-the-sphingosine-1-phosphate-receptor-2
#1
Birgitt Gutbier, Stefanie M Schönrock, Carolin Ehrler, Rainer Haberberger, Kristina Dietert, Achim D Gruber, Wolfgang Kummer, Laura Michalick, Wolfgang M Kuebler, Andreas C Hocke, Kolja Szymanski, Eleftheria Letsiou, Anja Lüth, Fabian Schumacher, Burkhard Kleuser, Timothy J Mitchell, Wilhelm Bertrams, Bernd Schmeck, Denise Treue, Frederick Klauschen, Torsten T Bauer, Mario Tönnies, Norbert Weissmann, Stefan Hippenstiel, Norbert Suttorp, Martin Witzenrath
OBJECTIVES: Severe pneumonia may evoke acute lung injury, and sphingosine-1-phosphate is involved in the regulation of vascular permeability and immune responses. However, the role of sphingosine-1-phosphate and the sphingosine-1-phosphate producing sphingosine kinase 1 in pneumonia remains elusive. We examined the role of the sphingosine-1-phosphate system in regulating pulmonary vascular barrier function in bacterial pneumonia. DESIGN: Controlled, in vitro, ex vivo, and in vivo laboratory study...
January 2, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29178318/thyroid-cancer-patients-receiving-an-interdisciplinary-team-based-care-approach-itca-thyca-appear-to-display-better-outcomes-program-evaluation-results-indicating-a-need-for-further-integrated-care-and-support
#2
Melissa Henry, Saul Frenkiel, Gabrielle Chartier, Richard Payne, Christina MacDonald, Martin Black, Alexander Mlynarek, Anthony Zeitouni, Karen Kost, Carmen Loiselle, Antoinette Ehrler, Zeev Rosberger, Michael Tamilia, Kelly Chang, Cecilia de la Mora, Camille Arbaud, Michael Hier
BACKGROUND: Thyroid cancer (ThyCa) is generally associated with a favorable prognosis and excellent surgical outcomes. Consequently, its treatment is medically focused and current guidelines recommend interdisciplinary care including access to a nurse for complex cases alone. To date, no studies have evaluated the need for and impact of an Interdisciplinary Team Based Care Approach(ITCA-ThyCa) for general Thyroid Cancer patients, including a dedicated nurse as part of a larger interdisciplinary team, as well as patient-reported outcomes, as is recommended worldwide in cancer care...
November 25, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29132435/vasculotide-reduces-pulmonary-hyperpermeability-in-experimental-pneumococcal-pneumonia
#3
Birgitt Gutbier, Xiaohui Jiang, Kristina Dietert, Carolin Ehrler, Jasmin Lienau, Paul Van Slyke, Harold Kim, Van C Hoang, Jason T Maynes, Daniel J Dumont, Achim D Gruber, Norbert Weissmann, Timothy J Mitchell, Norbert Suttorp, Martin Witzenrath
BACKGROUND: Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality worldwide. Despite effective antimicrobial therapy, CAP can induce pulmonary endothelial hyperpermeability resulting in life-threatening lung failure due to an exaggerated host-pathogen interaction. Treatment of acute lung injury is mainly supportive because key elements of inflammation-induced barrier disruption remain undetermined. Angiopoietin-1 (Ang-1)-mediated Tie2 activation reduces, and the Ang-1 antagonist Ang-2 increases, inflammation and endothelial permeability in sepsis...
November 13, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29039368/connecting-parents-to-a-pediatric-emergency-department-designing-a-mobile-app-based-on-patient-centred-care-principles
#4
Frederic Ehrler, Johan N Siebert, Jessica Rochat, Franck Schneider, Annick Galetto, Alain Gervaix, Christian Lovis
INTRODUCTION: Patient centred care fosters a holistic approach of care switching the focus from a disease perspective to a patient's experience perspective. Patient centred care is of particular importance in the context of paediatric emergency medicine. Indeed, parents entering a paediatric emergency department (PED) are usually under stress caused by their children's illness, the unfamiliar setting of the PED and delays of care. All these factors can deteriorate their experience as well as the relationships between healthcare providers, the patients and their parents...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28920081/modeling-the-performance-limitations-and-prospects-of-perovskite-si-tandem-solar-cells-under-realistic-operating-conditions
#5
Moritz H Futscher, Bruno Ehrler
Perovskite/Si tandem solar cells have the potential to considerably out-perform conventional solar cells. Under standard test conditions, perovskite/Si tandem solar cells already outperform the Si single junction. Under realistic conditions, however, as we show, tandem solar cells made from current record cells are hardly more efficient than the Si cell alone. We model the performance of realistic perovskite/Si tandem solar cells under real-world climate conditions, by incorporating parasitic cell resistances, nonradiative recombination, and optical losses into the detailed-balance limit...
September 8, 2017: ACS Energy Letters
https://www.readbyqxmd.com/read/28830854/a-mobile-device-app-to-reduce-medication-errors-and-time-to-drug-delivery-during-pediatric-cardiopulmonary-resuscitation-study-protocol-of-a-multicenter-randomized-controlled-crossover-trial
#6
Johan N Siebert, Frederic Ehrler, Christian Lovis, Christophe Combescure, Kevin Haddad, Alain Gervaix, Sergio Manzano
BACKGROUND: During pediatric cardiopulmonary resuscitation (CPR), vasoactive drug preparation for continuous infusions is complex and time-consuming. The need for individual specific weight-based drug dose calculation and preparation places children at higher risk than adults for medication errors. Following an evidence-based and ergonomic driven approach, we developed a mobile device app called Pediatric Accurate Medication in Emergency Situations (PedAMINES), intended to guide caregivers step-by-step from preparation to delivery of drugs requiring continuous infusion...
August 22, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28554878/adherence-to-aha-guidelines-when-adapted-for-augmented-reality-glasses-for-assisted-pediatric-cardiopulmonary-resuscitation-a-randomized-controlled-trial
#7
Johan N Siebert, Frederic Ehrler, Alain Gervaix, Kevin Haddad, Laurence Lacroix, Philippe Schrurs, Ayhan Sahin, Christian Lovis, Sergio Manzano
BACKGROUND: The American Heart Association (AHA) guidelines for cardiopulmonary resuscitation (CPR) are nowadays recognized as the world's most authoritative resuscitation guidelines. Adherence to these guidelines optimizes the management of critically ill patients and increases their chances of survival after cardiac arrest. Despite their availability, suboptimal quality of CPR is still common. Currently, the median hospital survival rate after pediatric in-hospital cardiac arrest is 36%, whereas it falls below 10% for out-of-hospital cardiac arrest...
May 29, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28479546/smartphones-to-access-to-patient-data-in-hospital-settings-authentication-solutions-for-shared-devices
#8
Frederic Ehrler, Katherine Blondon, Dominique Baillon-Bigotte, Christian Lovis
Although mobile devices become more and more common in clinicians' hands, transforming them into an institutional tool to access electronic health record information at the patient's bedside still raises many questions. One of these questions is the provenance of mobile devices when these are deployed at an institutional level. Some advocate the use of personal devices, known as BYOD, for its lower cost, others favor the use of institutional devices which allow a standardization of the development, deployment and support processes...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28423834/communication-of-children-symptoms-in-emergency-classification-of-the-terminology
#9
Jessica Rochat, Johan Siebert, Annick Galetto, Christian Lovis, Frédéric Ehrler
The significant part of non-urgent visits to the emergency highlight the necessity to advise people on the actions to take according to their symptoms. Although information sources are accessible through different channels their content often employs medical terminologies that are difficult to understand by laypersons. Our goal is to provide a terminology of the most common symptoms in pediatric emergency adapted to laypersons. This terminology is organized in a hierarchy by the mean of a card-sorting study...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28396080/laser-driven-formation-of-transient-local-ferromagnetism-in-ferh-thin-films
#10
A A Ünal, A Parabas, A Arora, J Ehrler, C Barton, S Valencia, R Bali, T Thomson, F Yildiz, F Kronast
The antiferromagnetic to ferromagnetic phase transition in FeRh can be induced globally by either heating the material above its phase transition temperature or applying a combination of external stimuli (such as mechanical strain, electric/magnetic fields) on the material preheated close to its transition temperature. On the other hand, to locally induce this phase transition is more desirable for applications and requires a confined source of energy such as a focused laser beam. Here we combine laser excitation with X-ray magnetic imaging to determine the effect of laser heating on the local and transient magnetization of FeRh using time-resolved photoelectron emission microscopy...
April 4, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28261671/a-silicon-singlet-fission-tandem-solar-cell-exceeding-100-external-quantum-efficiency-with-high-spectral-stability
#11
Luis M Pazos-Outón, Ju Min Lee, Moritz H Futscher, Anton Kirch, Maxim Tabachnyk, Richard H Friend, Bruno Ehrler
After 60 years of research, silicon solar cell efficiency saturated close to the theoretical limit, and radically new approaches are needed to further improve the efficiency. The use of tandem systems raises this theoretical power conversion efficiency limit from 34% to 45%. We present the advantageous spectral stability of using voltage-matched tandem solar cells with respect to their traditional series-connected counterparts and experimentally demonstrate how singlet fission can be used to produce simple voltage-matched tandems...
February 10, 2017: ACS Energy Letters
https://www.readbyqxmd.com/read/28148473/a-mobile-device-app-to-reduce-time-to-drug-delivery-and-medication-errors-during-simulated-pediatric-cardiopulmonary-resuscitation-a-randomized-controlled-trial
#12
RANDOMIZED CONTROLLED TRIAL
Johan N Siebert, Frederic Ehrler, Christophe Combescure, Laurence Lacroix, Kevin Haddad, Oliver Sanchez, Alain Gervaix, Christian Lovis, Sergio Manzano
BACKGROUND: During pediatric cardiopulmonary resuscitation (CPR), vasoactive drug preparation for continuous infusion is both complex and time-consuming, placing children at higher risk than adults for medication errors. Following an evidence-based ergonomic-driven approach, we developed a mobile device app called Pediatric Accurate Medication in Emergency Situations (PedAMINES), intended to guide caregivers step-by-step from preparation to delivery of drugs requiring continuous infusion...
February 1, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27758141/first-episode-of-acute-low-back-pain-an-exploratory-cluster-analysis-approach-for-early-detection-of-unfavorable-recovery
#13
Brigitte Wirth, Marco Ehrler, Barry Kim Humphreys
PURPOSE: To identify recovery patterns in patients with a first episode of acute low back pain (LBP) and to define risk factors for unfavorable outcome. METHODS: One hundred and eight patients (55 male, 53 female; mean age = 40.8, SD 14.2 years) rated pain (NRS) and disability [Oswestry Disability Index (ODI)] before the first treatment and 1 week, 1, 3, 6, and 12 months later. Hierarchical cluster analysis identified recovery patterns based on NRS data. Clusters were compared for age, NRS and ODI at baseline, pain reduction in the first week, gender, radicular signs and traumatic onset using one-way ANOVA (post hoc Bonferroni) and χ(2) tests...
October 19, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27713114/influence-of-pedometer-position-on-pedometer-accuracy-at-various-walking-speeds-a-comparative-study
#14
COMPARATIVE STUDY
Frederic Ehrler, Chloé Weber, Christian Lovis
BACKGROUND: Demographic growth in conjunction with the rise of chronic diseases is increasing the pressure on health care systems in most OECD countries. Physical activity is known to be an essential factor in improving or maintaining good health. Walking is especially recommended, as it is an activity that can easily be performed by most people without constraints. Pedometers have been extensively used as an incentive to motivate people to become more active. However, a recognized problem with these devices is their diminishing accuracy associated with decreased walking speed...
October 6, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27676838/assessment-of-therapeutic-education-in-135-lower-limb-amputees
#15
Chloé Blum, Solange Ehrler, Marie-Eve Isner
OBJECTIVE: Therapeutic patient education (TPE) is a continuous process for chronic disease. TPE enables patients to improve and acquire the skills that are necessary for self-care and self-management. We wanted to determine the place of self-care in patients following lower limb amputation by evaluating prosthetic and limb management and prosthesis use. MATERIAL/PATIENTS AND METHODS: To this aim, we involved 135 trans-tibial amputees between May 2011 and December 2013 who were fitted with contact silicone socket prosthesis with distal lock...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27577371/addressing-the-complexity-of-mobile-app-design-in-hospital-setting-with-a-tailored-software-development-life-cycle-model
#16
Frederic Ehrler, Christian Lovis, Katherine Blondon
Recent studies on workflow processes in hospital settings have shown that, since the introduction of EHRs, care-providers spend an increasing amount of their time on documentation rather than on bedside patient care. In order to improve the bedside work process and facilitate bedside documentation, we are developing an evidence-based mobile app for healthcare providers. In this paper, we present a tailored software development life cycle model that we created and validated during the design and development of this smartphone application...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27332296/improving-drugs-administration-safety-in-pediatric-resuscitation-using-mobile-technology
#17
Hamdi Hagberg, Johan Siebert, Alain Gervaix, Peter Daehne, Christian Lovis, Sergio Manzano, Frederic Ehrler
The fast preparation of drugs during pediatric resuscitation is of utmost importance. The influence of the patient's weight on the drug doses requires to perform complex calculations and is a source of errors. A technological solution could be a real help in avoiding these kinds of mistakes. Relying on a user centered approach we have developed an application supporting drug preparation. It has been tested in simulations with predefined scenario. The developed tool consists of a screen displaying a list of drug that can be administered...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27332295/individual-nomad-clinical-assistant-supporting-nurses-at-the-point-of-care
#18
Yvann Argentin, Florent Gluck, Christian Lovis, Frederic Ehrler
Accessing patients' data at the point of care has the potential to ease the workflow of nurses and to improve the documentation. We have launched an initiative to develop a mobile assistant focused on managing nurses' daily intervention. The design has required the involvement of many stakeholder and has followed a user centered design process. The evaluation is planned in two stages with an increasing level of ecology. The solution is a client server application displaying a contextualized view on nurses' interventions...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27332258/improving-patients-experience-in-peadiatric-emergency-waiting-room
#19
Frederic Ehrler, Johan Siebert, Rolf Wipfli, Cyrille Duret, Alain Gervaix, Christian Lovis
When visiting the emergency department, the perception of the time spent in the waiting room before the beginning of the care, may influence patients' experience. Based on models of service evaluation, highlighting the importance of informing people about their waiting process and their place in the queue, we have developed an innovative information screen aiming at improving perception of time by patients. Following an iterative process, a group of experts including computer scientists, ergonomists and caregivers designed a solution adapted to the pediatric context...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27255612/how-regrouping-alerts-in-computerized-physician-order-entry-layout-influences-physicians-prescription-behavior-results-of-a-crossover-randomized-trial
#20
Rolf Wipfli, Frederic Ehrler, Georges Bediang, Mireille Bétrancourt, Christian Lovis
BACKGROUND: As demonstrated in several publications, low positive predictive value alerts in computerized physician order entry (CPOE) induce fatigue and may interrupt physicians unnecessarily during prescription of medication. Although it is difficult to increase the consideration of medical alerts by physician through an improvement of their predictive value, another approach consists to act on the way they are presented. The interruption management model inspired us to propose an alternative alert display strategy of regrouping the alerts in the screen layout, as a possible solution for reducing the interruption in physicians' workflow...
2016: JMIR Human Factors
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