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Tim3 NK cell

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https://www.readbyqxmd.com/read/27458246/antitumor-effect-of-programmed-death-1-pd-1-blockade-in-humanized-the-nog-mhc-double-knockout-mouse
#1
Tadashi Ashizawa, Akira Iizuka, Chizu Nonomura, Ryota Kondou, Chie Maeda, Haruo Miyata, Takashi Sugino, Koichi Mitsuya, Nakamasa Hayashi, Yoko Nakasu, Kouji Maruyama, Ken Yamaguchi, Ikumi Katano, Mamoru Ito, Yasuto Akiyama
PURPOSE: Humanized mouse models using NOD/Shi-scid-IL2rγ(null) (NOG) and NOD/LtSz-scid IL2rγ(null) (NSG) mouse are associated with several limitations, such as long incubation time for stem cell engraftment and the development of xenograft versus host disease in mice injected with peripheral blood mononuclear cells (PBMCs). To solve problems, we used humanized major histocompatibility class I- and class II-deficient NOG mice (referred to as NOG-dKO) to evaluate the antitumor effect of anti-programmed death-1 (PD-1) antibody...
July 25, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27344341/modulation-of-innate-immunity-in-the-tumor-microenvironment
#2
REVIEW
Elena Gonzalez-Gugel, Mansi Saxena, Nina Bhardwaj
A recent report from the Center for Disease Control identified melanoma as being among the highest causes of cancer-related mortalities in the USA. While interventions such as checkpoint blockade have made substantial impact in terms of improving response rates and overall survival, a significant number of patients fail to respond to treatment or become resistant to therapy. A better understanding of the tumor microenvironment in these patients becomes imperative for identifying immune suppressive mechanisms that impact the development of effective anti-tumor immune responses...
October 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27192116/the-ido1-selective-inhibitor-epacadostat-enhances-dendritic-cell-immunogenicity-and-lytic-ability-of-tumor-antigen-specific-t-cells
#3
Caroline Jochems, Massimo Fantini, Romaine I Fernando, Anna R Kwilas, Renee N Donahue, Lauren M Lepone, Italia Grenga, Young-Seung Kim, Martin W Brechbiel, James L Gulley, Ravi A Madan, Christopher R Heery, James W Hodge, Robert Newton, Jeffrey Schlom, Kwong Y Tsang
Epacadostat is a novel inhibitor of indoleamine-2,3-dioxygenase-1 (IDO1) that suppresses systemic tryptophan catabolism and is currently being evaluated in ongoing clinical trials. We investigated the effects of epacadostat on (a) human dendritic cells (DCs) with respect to maturation and ability to activate human tumor antigen-specific cytotoxic T-cell (CTL) lines, and subsequent T-cell lysis of tumor cells, (b) human regulatory T cells (Tregs), and (c) human peripheral blood mononuclear cells (PBMCs) in vitro...
May 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/26157174/impaired-nk-cell-activation-and-chemotaxis-toward-dendritic-cells-exposed-to-complement-opsonized-hiv-1
#4
Rada Ellegård, Elisa Crisci, Jonas Andersson, Esaki M Shankar, Sofia Nyström, Jorma Hinkula, Marie Larsson
Mucosa resident dendritic cells (DCs) may represent one of the first immune cells that HIV-1 encounters during sexual transmission. The virions in body fluids can be opsonized with complement factors because of HIV-mediated triggering of the complement cascade, and this appears to influence numerous aspects of the immune defense targeting the virus. One key attribute of host defense is the ability to attract immune cells to the site of infection. In this study, we investigated whether the opsonization of HIV with complement (C-HIV) or a mixture of complement and Abs (CI-HIV) affected the cytokine and chemokine responses generated by DCs, as well as their ability to attract other immune cells...
August 15, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/25251283/broad-spectrum-activity-of-a-lectin-like-bacterial-serine-protease-family-on-human-leukocytes
#5
Jorge Luis Ayala-Lujan, Vidhya Vijayakumar, Mei Gong, Rachel Smith, Araceli E Santiago, Fernando Ruiz-Perez
The serine protease autotransporter from Enterobacteriaceae (SPATE) family, which number more than 25 proteases with apparent diverse functions, have been phylogenetically divided into two distinct classes, designated 1 and 2. We recently demonstrated that Pic and Tsh, two members of the class-2 SPATE family produced by intestinal and extraintestinal pathogenic E. coli, were able to cleave a number of O-glycosylated proteins on neutrophils and lymphocytes resulting in impaired leukocyte functions. Here we show that most members of the class-2 SPATE family have lectin-like properties and exhibit differential protease activity reliant on glycoprotein type and cell lineage...
2014: PloS One
https://www.readbyqxmd.com/read/25220367/expression-of-coinhibitory-receptors-on-t-cells-in-the-microenvironment-of-usual-vulvar-intraepithelial-neoplasia-is-related-to-proinflammatory-effector-t-cells-and-an-increased-recurrence-free-survival
#6
Edith M G van Esch, Mariette I E van Poelgeest, Simone Kouwenberg, E Michelle Osse, J Baptist M Z Trimbos, Gert Jan Fleuren, Ekaterina S Jordanova, Sjoerd H van der Burg
Human papillomavirus-induced usual-type vulvar intraepithelial neoplasia (uVIN) are infiltrated by immune cells but apparently not cleared. A potential explanation for this is an impaired T cell effector function by an immunesuppressive milieu, coinfiltrating regulatory T cells or the expression of coinhibitory molecules. Here, the role of these potential inhibitory mechanisms was evaluated by a detailed immunohistochemical analysis of T cell infiltration in the context of FoxP3, Tbet, indoleamine 2,3-dioxygenase, programmed cell death 1, T cell immunoglobulin mucin 3 (TIM3), natural killer cell lectin-like receptor A (NKG2A) and galectins-1, -3 and -9...
February 15, 2015: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/24651720/peripheral-blood-tim-3-positive-nk-and-cd8-t-cells-throughout-pregnancy-tim-3-galectin-9-interaction-and-its-possible-role-during-pregnancy
#7
Matyas Meggyes, Eva Miko, Beata Polgar, Barbara Bogar, Balint Farkas, Zsolt Illes, Laszlo Szereday
PROBLEM: The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with a conserved structure and important immunological functions. Identification of Galectin-9 as a ligand for TIM-3 has established the Galectin-9/TIM-3 pathway as an important negative regulator of Th1 immunity and tolerance induction. Data about the TIM-3/Gal-9 pathway in the pathogenesis of human diseases is emerging, but their possible role during human pregnancy is not precisely known...
2014: PloS One
https://www.readbyqxmd.com/read/23554257/tim3-expression-by-leukemic-and-non-leukemic-myeloblasts
#8
Christine G Roth, Kelly Garner, Stephen Ten Eyck, Michael Boyiadzis, Lawrence P Kane, Fiona E Craig
BACKGROUND: T-cell immunoglobulin mucin-3 (TIM3) has recently been described as an acute myeloid leukemia (AML) stem cell antigen expressed on leukemic myeloblasts, but not on normal hematopoietic stem cells. TIM3 is also expressed by monocytes, natural killer cells, and several T cell subsets; however, normal myeloblasts have not been well-characterized or compared to AML. A specific flow cytometric marker capable of separating leukemic myeloblasts from non-neoplastic myeloblasts would be diagnostically useful, especially in the post-chemotherapy setting...
May 2013: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/15557145/novel-insights-on-human-nk-cells-immunological-modalities-revealed-by-gene-expression-profiling
#9
COMPARATIVE STUDY
Jacob Hanna, Pamela Bechtel, Yufeng Zhai, Fadi Youssef, Karen McLachlan, Ofer Mandelboim
As part of the innate immune system, human NK cells play a critical role early in the systemic host defense against pathogens and tumor cells. Recent studies suggest a more complex view of NK cell behavior, as different functions and tissue localizing capabilities seem to be preferentially assigned to distinct subpopulations of NK cells, CD56(dim)CD16(+) or CD56(bright)CD16(-). In this study, we used oligonucleotide microarrays to compare the expression profile of approximately 20,000 genes in three NK cell subpopulations: peripheral blood-derived CD56(dim)CD16(+), CD56(bright)CD16(-), and in vitro-activated CD16(+) NK cells...
December 1, 2004: Journal of Immunology: Official Journal of the American Association of Immunologists
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