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https://www.readbyqxmd.com/read/27909656/outcomes-of-demineralized-bone-matrix-enriched-with-concentrated-bone-marrow-aspirate-in-lumbar-fusion
#1
Remi M Ajiboye, Mark A Eckardt, Jason T Hamamoto, Benjamin Plotkin, Michael D Daubs, Jeffrey C Wang
BACKGROUND: Multiple studies have demonstrated that a significant amount of variability exists in various demineralized bone matrix (DBM) formulations, which casts doubts on its reliability in consistently promoting fusion. Bone marrow aspirate (BMA) is a cellular based graft that contains mesenchymal stem cells (MSCs) and growth factors can confer osteogenic and osteoinductive potential to DBM. The goal of this study was to describe the outcome of DBM enriched with concentrated BMA in patients undergoing combined lumbar interbody and posterolateral fusion...
2016: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/27904089/structure-cytotoxicity-relationship-of-methacrylate-based-resin-monomers-as-evaluated-by-an-anti-oxidant-responsive-element-luciferase-reporter-assay
#2
Miki Egashira, Takahiro Suzuki, Ai Orimoto, Tohru Obata, Hiroshi Nakamura, Motohiro Tanaka, Takao Kanamori, Tatsushi Kawai
To investigate the chemical structure-cytotoxicity relationship of methacrylate-based resin monomers, we studied their effects on anti-oxidant responsive element (ARE)-mediated transcription. HepG2 cells stably expressing an ARE-regulated luciferase reporter gene were cultured for 6 h with various concentrations of several resin monomers and subjected to a luciferase assay. The doseresponse curves observed for hydrophobic monomers with different hydrocarbon chains (MMA, EMA, PMA and BMA) began to rise at concentrations between 0...
2016: Dental Materials Journal
https://www.readbyqxmd.com/read/27862377/merging-pedigree-databases-to-describe-and-compare-mating-practices-and-gene-flow-between-pedigree-dogs-in-france-sweden-and-the-uk
#3
S Wang, G Leroy, S Malm, T Lewis, E Strandberg, W F Fikse
Merging pedigree databases across countries may improve the ability of kennel organizations to monitor genetic variability and health-related issues of pedigree dogs. We used data provided by the Société Centrale Canine (France), Svenska Kennelklubben (Sweden) and the Kennel Club (UK) to study the feasibility of merging pedigree databases across countries and describe breeding practices and international gene flow within the following four breeds: Bullmastiff (BMA), English setter (ESE), Bernese mountain dog (BMD) and Labrador retriever (LBR)...
November 10, 2016: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/27858891/pediatric-visceral-leishmaniasis-in-northwest-of-iran
#4
Babak Abdinia, Mohammad Oliaei-Motlagh, Amir Teimouri-Dereshki
Leishmaniasis is one of the major health problems in Iran. Although the incidence of visceral leishmaniasis (VL) is reported almost everywhere, the northwestern Iran is one of the major endemic regions.To do this study, clinical, laboratory as well as disease characteristics of children admitted to Children Cure and Health Hospital, Tabriz University of Medical Sciences, were examined as the reference hospital for the treatment of VL in northwestern Iran.In this study, 156 children hospitalized in a pediatric hospital from 2000 to 2015 for VL were included...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27834489/british-medical-association-bma-patient-information-awards
#5
(no author information available yet)
No abstract text is available yet for this article.
November 11, 2016: Journal of Visual Communication in Medicine
https://www.readbyqxmd.com/read/27834271/bma-relinquishes-ability-to-take-strike-action-over-junior-contract
#6
Abi Rimmer
No abstract text is available yet for this article.
November 10, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27829312/cudc-907-promotes-bone-marrow-adipocytic-differentiation-through-inhibition-of-histone-deacetylase-and-regulation-of-cell-cycle
#7
Dalia Ali, Hassan Alshammari, Radhakrishnan Vishnubalaji, Elna Paul Chalisserry, Rimi Hamam, Musaed Alfayez, Moustapha Kassem, Abdullah Aldahmash, Nehad M Alajez
The role of bone marrow adipocytes (BMA) in overall energy metabolism and their effects on bone mass is currently an area of intensive investigation. BMA differentiate from bone marrow stromal cells (BMSCs), however, the molecular mechanisms regulating BMA differentiation are not fully understood. Herein, we investigated the effect of CUDC-907, identified by screening an epigenetics small-molecule library, on adipocytic differentiation of human BMSCs, and determined its molecular mechanism of action. hMSCs exposed to CUDC-907 (500 nM) exhibited enhanced adipocytic differentiation (~2...
November 9, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27827558/interaction-of-bioactive-compounds-on-capillary-inner-surfaces-bearing-a-dense-thermoresponsive-polymer-brush
#8
Takuya Koriyama, Yosuke Takayama, Chiho Hisatsune, Taka-Aki Asoh, Akihiko Kikuchi
To confirm the modification of a dense thermoresponsive polymer brush on a silica surface by surface-initiated (SI) atom transfer radical polymerization (ATRP), poly(N-isopropylacrylamide) (PNIPAAm) was polymerized from a free ATRP initiator and an ATRP initiator immobilized silica particle (SiP) via ATRP under various initiator concentrations. The obtained PNIPAAm exhibited a well-controlled molecular weight and modification of the concentrated PNIPAAm brush on the SiP surface was confirmed. Based on the optimal ATRP conditions, the PNIPAAm- and poly(NIPAAm-co-butyl methacrylate [BMA]) (PIB)-grafted capillary lumen were prepared by SI-ATRP and used as capillary columns for micro high-performance liquid chromatography for the modulation of biomolecular interactions...
November 21, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27823105/nursingstandard-com
#9
(no author information available yet)
1 NHS nurses fear that the decision by junior doctors to abandon strike action could mean nurses are next in line to have new work contracts imposed on them by the government. Read more rcni.com/BMA-strike-off.
October 5, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27818475/sector-based-assessment-of-infarct-size-on-late-gadolinium-enhancement-mri-in-a-mouse-model-of-acute-myocardial-infarction
#10
Cheongsoo Park, Eun-Hye Park, Kiyuk Chang, Kwan Soo Hong
Scoring of myocardial infarction (MI) disease extent in cardiac magnetic resonance (CMR) images has been generally presented in terms of area-based infarct size. However, gradual thinning of the infarcted wall and compensatory hypertrophy of the noninfarcted remote wall during left ventricular (LV) remodeling after MI complicate the accuracy of infarct size measurement. In this study, we measured and compared infarct sizes in mice on late gadolinium enhancement (LGE) images using area-, length-, and radial sector-based methods...
November 4, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27802598/reduced-blood-cell-adhesion-on-polypropylene-substrates-by-a-simple-surface-zwitterionization
#11
Sheng-Han Chen, Yung Chang, Kazuhiko Ishihara
To conquer thrombogenic reactions of hydrocarbon-based biomaterials in clinical blood treatment, we introduce a model study of a surface zwitterionization of polypropylene (PP) substrate using a set of well-defined copolymers for controlling the adhesion of blood cells in vitro. Random and block copolymers containing zwitterionic units of 2-methacryloyloxyethyl phosphorylcholine (MPC), [3-(methacryloylamino)propyl] dimethyl(3-sulfopropyl)ammonium hydroxide inner salt (SBAA), or non-ionic units of 2-hydroxyethyl methacrylate (HEMA) with a controlled hydrophobic segment of 70% n-butyl methacrylate (BMA) units in these polymers were synthesized by reversible addition-fragmentation chain transfer polymerization...
November 1, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27788908/performing-a-better-bone-marrow-aspiration
#12
REVIEW
Mayo F Friedlis, Christopher J Centeno
Bone marrow aspiration (BMA) is increasingly being used to harvest stem cells for use in regenerative medicine. The focus of BMA in interventional orthopedics is to maximize the yield of mesenchymal stem cells. The authors present an improved method for BMA that involves fluoroscope or ultrasound guidance combined with anesthesia; in the authors' experience, it produces the highest possible stem cell yield and is well tolerated by patients. The authors provide a step-by-step guide to the process, along with a discussion of technical and other considerations and quick reference guides for ultrasound- and fluoroscope-guided BMA...
November 2016: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27780815/bma-calls-for-national-prescription-drug-helpline
#13
Zosia Kmietowicz
No abstract text is available yet for this article.
October 25, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27769462/green-synthesis-of-mesoporous-molecular-sieve-incorporated-monoliths-using-room-temperature-ionic-liquid-and-deep-eutectic-solvents
#14
Li-Shun Zhang, Qing-Li Zhao, Xin-Xin Li, Xi-Xi Li, Yan-Ping Huang, Zhao-Sheng Liu
A hybrid monolith incorporated with mesoporous molecular sieve MCM-41 of uniform pore structure and high surface area was prepared with binary green porogens in the first time. With a mixture of room temperature ionic liquids and deep eutectic solvents as porogens, MCM-41 was modified with 3-(trimethoxysilyl) propyl methacrylate (γ-MPS) and the resulting MCM-41-MPS was incorporated into poly (BMA-co-EDMA) monoliths covalently. Because of good dispersibility of MCM-41-MPS in the green solvent-based polymerization system, high permeability and homogeneity for the resultant hybrid monolithic columns was achieved...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27734341/prognostic-risk-factors-in-patients-with-bone-metastasis-from-colorectal-cancer
#15
Fangqi Liu, Jiang Zhao, Jie Xie, Li Xie, Ji Zhu, Sanjun Cai, Hongtu Zheng, Ye Xu
The morbidity of bone metastasis (BM) from colorectal cancer (CRC) is increasing more than ever; however, insufficient research on BM from CRC leads to reduced awareness of the issue. Therefore, the aim of this study was to evaluate the clinical features and prognostic risk factors of CRC patients with BM. Clinical data were retrospectively analyzed for a total of 242 CRC patients with BM. Of the 242 CRC patients with BM, 52 (21.5 %) had bone metastasis alone (BMA) and 190 (78.5 %) had both bone and visceral metastasis (BM&VM)...
October 12, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27731629/collaborative-action-of-surface-chemistry-and-topography-in-the-regulation-of-mesenchymal-and-epithelial-markers-and-the-shape-of-cancer-cells
#16
Junsheng Li, Barbara Kwiatkowska, Hao Lu, Maren Voglstätter, Erika Ueda, Michael Grunze, Jonathan Sleeman, Pavel A Levkin, Irina Nazarenko
Malignant transformation is associated with enhancement of cell plasticity, which allows cancer cells to survive under different conditions by adapting to their microenvironment during growth and metastatic spread. Much effort has been devoted to understanding the molecular mechanisms of these processes. Although the importance of the extracellular matrix and of surface properties in these mechanisms is evident, the direct impact of distinct physical and chemical surfaces characteristics on cell fate remains unclear...
October 12, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27722360/electron-and-nuclear-dynamics-following-ionisation-of-modified-bismethylene-adamantane
#17
Morgane Vacher, Fabio E A Albertani, Andrew J Jenkins, Iakov Polyak, Michael J Bearpark, Michael A Robb
We have simulated the coupled electron and nuclear dynamics using the Ehrenfest method upon valence ionisation of modified bismethylene-adamantane (BMA) molecules where there is an electron transfer between the two π bonds. We have shown that the nuclear motion significantly affects the electron dynamics after a few fs when the electronic states involved are close in energy. We have also demonstrated how the non-stationary electronic wave packet determines the nuclear motion, more precisely the asymmetric stretching of the two π bonds, illustrating "charge-directed reactivity"...
September 14, 2016: Faraday Discussions
https://www.readbyqxmd.com/read/27714525/a-comparison-of-adherence-timeframes-using-missed-dose-items-and-their-associations-with-viral-load-in-routine-clinical-care-is-longer-better
#18
H M Crane, R M Nance, J A C Delaney, R J Fredericksen, A Church, J M Simoni, R D Harrington, S Dhanireddy, S A Safren, M E McCaul, W B Lober, P K Crane, I B Wilson, M J Mugavero, M M Kitahata
Questions remain regarding optimal timeframes for asking about adherence in clinical care. We compared 4-, 7-, 14-, 30-, and 60-day timeframe missed dose items with viral load levels among 1099 patients on antiretroviral therapy in routine care. We conducted logistic and linear regression analyses examining associations between different timeframes and viral load using Bayesian model averaging (BMA). We conducted sensitivity analyses with subgroups at increased risk for suboptimal adherence (e.g. patients with depression, substance use)...
October 6, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27702818/paired-high-content-analysis-of-prostate-cancer-cells-in-bone-marrow-and-blood-characterizes-increased-androgen-receptor-expression-in-tumor-cell-clusters
#19
Peter Kuhn, Anders Carlsson, Madelyn S Luttgen, Kevin Keomanee Dizon, Patricia Troncoso, Paul Corn, Anand Kolatkar, James B Hicks, Christopher Logothetis, Amado J Zurita
PURPOSE: Recent studies demonstrate that prostate cancer clones from different metastatic sites are dynamically represented in the blood of patients over time, suggesting that the paired evaluation of tumor cells in circulation and bone marrow, the primary target for prostate cancer metastasis, may provide complementary information. EXPERIMENTAL DESIGN: We adapted our single-cell high-content liquid biopsy platform to bone marrow aspirates (BMA), to concurrently identify and characterize prostate cancer cells in patients' blood and bone and thus discern features associated to tumorigenicity and dynamics of metastatic progression...
October 4, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27695438/increased-bone-marrow-adiposity-in-a-context-of-energy-deficit-the-tip-of-the-iceberg
#20
Olfa Ghali, Nathalie Al Rassy, Pierre Hardouin, Christophe Chauveau
Elevated bone marrow adiposity (BMA) is defined as an increase in the proportion of the bone marrow (BM) cavity volume occupied by adipocytes. This can be caused by an increase in the size and/or number of adipocytes. BMA increases with age in a bone-site-specific manner. This increase may be linked to certain pathophysiological situations. Osteoporosis or compromised bone quality is frequently associated with high BMA. The involvement of BM adipocytes in bone loss may be due to commitment of mesenchymal stem cells to the adipogenic pathway rather than the osteogenic pathway...
2016: Frontiers in Endocrinology
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