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https://www.readbyqxmd.com/read/29035643/role-of-bone-modifying-agents-in-metastatic-breast-cancer-an-american-society-of-clinical-oncology-cancer-care-ontario-focused-guideline-update
#1
Catherine Van Poznak, Mark R Somerfield, William E Barlow, J Sybil Biermann, Linda D Bosserman, Mark J Clemons, Sukhbinder K Dhesy-Thind, Melissa S Dillmon, Andrea Eisen, Elizabeth S Frank, Reshma Jagsi, Rachel Jimenez, Richard L Theriault, Theodore A Vandenberg, Gary C Yee, Beverly Moy
Purpose To update, in collaboration with Cancer Care Ontario (CCO), key recommendations of the American Society of Clinical Oncology (ASCO) guideline on the role of bone-modifying agents (BMAs) in metastatic breast cancer. This focused update addressed the new data on intervals between dosing and the role of BMAs in control of bone pain. Methods A joint ASCO-CCO Update Committee conducted targeted systematic literature reviews to identify relevant studies. Results The Update Committee reviewed three phase III noninferiority trials of dosing intervals, one systematic review and meta-analysis of studies of de-escalation of BMAs, and two randomized trials of BMAs in control of pain secondary to bone metastases...
October 16, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29020744/fastbma-scalable-network-inference-and-transitive-reduction
#2
Ling-Hong Hung, Kaiyuan Shi, Migao Wu, William Chad Young, Adrian E Raftery, Ka Yee Yeung
Inferring genetic networks from genome-wide expression data is extremely demanding computationally. We have developed fastBMA, a distributed, parallel, and scalable implementation of Bayesian model averaging (BMA) for this purpose. fastBMA also includes a computationally efficient module for eliminating redundant indirect edges in the network by mapping the transitive reduction to an easily solved shortest-path problem. We evaluated the performance of fastBMA on synthetic data and experimental genome-wide time series yeast and human datasets...
October 1, 2017: GigaScience
https://www.readbyqxmd.com/read/28978632/bma-calls-for-urgent-meeting-with-health-secretary-over-gp-crisis
#3
Jacqui Wise
No abstract text is available yet for this article.
October 4, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28976432/the-efficiency-of-bone-marrow-aspiration-for-the-harvest-of-connective-tissue-progenitors-from-the-human-iliac-crest
#4
Thomas E Patterson, Cynthia Boehm, Chizu Nakamoto, Richard Rozic, Esteban Walker, Nicolas S Piuzzi, George F Muschler
BACKGROUND: The rational design and optimization of tissue engineering strategies for cell-based therapy requires a baseline understanding of the concentration and prevalence of osteogenic progenitor cell populations in the source tissues. The aim of this study was to (1) define the efficiency of, and variation among individuals in, bone marrow aspiration as a means of osteogenic connective tissue progenitor (CTP-O) harvest compared with harvest from iliac cancellous bone, and (2) determine the location of CTP-Os within native cancellous bone and their distribution between the marrow-space and trabecular-surface tissue compartments...
October 4, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28935678/bma-urges-more-career-flexibility-and-better-occupational-support-to-fight-workforce-crisis
#5
Abi Rimmer
No abstract text is available yet for this article.
September 21, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28901869/the-expulsion-of-south-africa-and-rhodesia-from-the-commonwealth-medical-association-1947-70
#6
John Stewart
In 1970 the medical associations of South Africa and Rhodesia (now, Zimbabwe) were expelled from the Commonwealth Medical Association. The latter had been set up, as the British Medical Commonwealth Medical Conference, in the late 1940s by the British Medical Association (BMA). These expulsions, and the events leading up to them, are the central focus of this article. The BMA's original intention was to establish an organisation bringing together the medical associations of the constituent parts of the expanding Commonwealth...
October 2017: Medical History
https://www.readbyqxmd.com/read/28891421/bone-marrow-aspiration-for-regenerative-orthopedic-intervention-technique-with-ultrasound-guidance-for-needle-placement
#7
Shane A Shapiro, Jennifer R Arthurs
AIM: We review relevant anatomy of the iliac crest, and describe an interventional technique to maximize harvesting of desired progenitor cells with ultrasound to guide safe trochar placement. MATERIALS & METHODS: We validated the technique on both sides of the pelvis in four human cadavers. RESULTS: Using ultrasound guidance, 32 BMA needles were placed in a safe zone along various portions of the iliac crest. CONCLUSION: Ultrasound guidance can improve accuracy of bone marrow aspirations form the iliac crest...
September 11, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28890971/quantitative-interpretation-of-impedance-spectroscopy-data-on-porous-lsm-electrodes-using-x-ray-computed-tomography-and-bayesian-model-based-analysis
#8
Giuseppe F Brunello, William K Epting, Juwana de Silva, Paul A Salvador, Shawn Litster, Harry O Finklea, Yueh-Lin Lee, Kirk R Gerdes, David S Mebane
It is broadly understood that strontium-doped lanthanum manganate (LSM) cathodes for solid oxide fuel cells (SOFCs) have two pathways for the reduction of oxygen: a surface-mediated pathway culminating in oxygen incorporation into the electrolyte at the triple-phase boundary (TPB), and a bulk-mediated pathway involving oxygen transfer across the electrode-electrolyte interface. Patterned electrode and thin film experiments have shown that both pathways are active in LSM. Porous electrode geometries more commonly found in SOFCs have not been amenable for precise measurement of active electrode width because of the difficulty in precisely measuring the electrode geometry...
September 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28890905/single-versus-multiple-site-harvesting-techniques-for-bone-marrow-concentrate-evaluation-of-aspirate-quality-and-pain
#9
Kristin Oliver, Tariq Awan, Matthew Bayes
BACKGROUND: Bone marrow concentrate (BMC) is growing in popularity as an alternative treatment option in orthopaedics. The regenerative capacity of BMC has been linked to the number of mesenchymal stem cells (MSCs) present in the graft at the time of its clinical application. MSC counts in bone marrow aspirate (BMA) are affected by harvest technique, but controversy exists over which aspiration method optimizes cellular yield while taking patient comfort and risk into consideration. PURPOSE: To compare a single- versus multiple-site bone marrow aspiration technique to determine which would generate a sufficient volume of high-quality BMA for concentration into a BMC graft...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28882855/over-half-of-gps-are-prepared-to-close-their-lists-to-new-patients-says-bma
#10
Abi Rimmer
No abstract text is available yet for this article.
September 7, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28877909/scottish-government-must-act-to-fill-consultant-vacancies-says-bma
#11
Abi Rimmer
No abstract text is available yet for this article.
September 6, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28844196/atypical-femoral-fracture-associated-with-bone-modifying-agent-for-bone-metastasis-of-breast-cancer-a-report-of-two-cases
#12
Daisuke Tateiwa, Hidetatsu Outani, Saya Iwasa, Yoshinori Imura, Takaaki Tanaka, Kazuya Oshima, Norifumi Naka, Nobuhito Araki
Atypical femoral fractures (AFFs) are recently observed as a complication of long-term bone-modifying agent (BMA; bisphosphonate or denosumab) therapy for bone metastases. We describe the cases of two women diagnosed with breast cancer who developed incomplete AFF associated with BMAs prescribed for bone metastases. Radiographs of their femurs revealed thickening of the lateral subtrochanteric cortex, and tomosynthesis revealed a visible fracture line in the thickened cortex. They were initially treated with conservative management; however, the incomplete fracture resulted in a complete fracture...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28839367/simultaneous-quantitation-of-six-aconitum-alkaloids-and-three-flavonoids-in-the-herb-couple-of-radix-aconiti-lateralis-radix-glycyrrhizae-fuzi-gancao-by-uhplc-esi-ms-ms
#13
Xiao Fu, Rongrong Lu, Songsong Zhao
BACKGROUND: Fuzi-Gancao herb couple is one of the commonly used herb couples involved in the traditional Chinese medicine formulations, with radix aconiti lateralis (Fuzi in Chinese) and radix glycyrrhizae (Gancao in Chinese) as a ratio of 1:1. Alkaloids and flavonoids were considered as the main active ingredients of Fuzi-Gancao herb couple. However, no analytical methods have been reported to quantitatively analyze these activity ingredients in Fuzi-Gancao herb couple simultaneously...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28830856/bma-laments-disappointing-pace-of-increase-in-gp-numbers
#14
Abi Rimmer
No abstract text is available yet for this article.
August 22, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28821476/bma-calls-for-tougher-action-on-food-industry-to-curb-childhood-obesity
#15
Abi Rimmer
No abstract text is available yet for this article.
August 18, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28816829/treatment-outcome-of-metastatic-spine-tumor-in-lung-cancer-patients-did-the-treatments-improve-their-outcomes
#16
Hiroshi Uei, Yasuaki Tokuhashi, Masafumi Maseda
STUDY DESIGN: A retrospective, single-center study. OBJECTIVE: Investigation of the changes in the treatment outcomes of patients with lung cancer-derived metastatic spine tumors SUMMARY OF BACKGROUND DATA.: Metastatic spine tumors derived from lung cancer had been progressive, and their prognosis is poor. It has recently been reported that the use of molecularly targeted drugs and bone-modifying agents (BMA) improved the treatment outcomes of patients with lung cancer, but no detailed information about the treatment of metastatic spine tumors has been reported...
August 14, 2017: Spine
https://www.readbyqxmd.com/read/28808602/high-lumbar-noninstrumented-fusion-rates-using-lamina-autograft-and-nanoss-bone-marrow-aspirate
#17
Nancy E Epstein
BACKGROUND: Patients with marked osteoporosis and/or obesity/morbid obesity and severe multilevel lumbar stenosis and other pathology often undergo multilevel laminectomies with non instrumented posterolateral fusions (PLF). The other pathology may include combinations of degenerative spondylolisthesis/lysis, foraminal/far lateral discs, and/or synovial cysts requiring more extensive facet resections. Presently, spine surgeons often use bone graft expanders to supplement the lamina autograft harvested in the course of laminectomy/decompressions for the PLF mass...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28808601/high-posterior-cervical-fusion-rates-with-iliac-autograft-and-nanoss-bone-marrow-aspirate
#18
Nancy E Epstein
BACKGROUND: Patients with severe cervical multilevel stenosis and an adequate lordotic curvature often undergo multilevel laminectomies with posterior instrumented fusions. Although the "gold standard" for the fusion mass remains iliac crest autograft, many require additional volume provided by bone graft expanders. Here, we studied the fusion rates for 32 patients undergoing multilevel cervical laminectomy and vertex/rod/eyelet/titanium cable fusions utilizing lamina/iliac autograft and the bone graft expander Nanoss (RTI Surgical, Alachua, FL, USA) with autogenous bone marrow aspirate (BMA)...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28754698/plans-for-major-nhs-cuts-are-shrouded-in-secrecy-warns-bma
#19
Abi Rimmer
No abstract text is available yet for this article.
July 28, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28750725/hydroxyapatite-collagen-scaffold-with-autologous-bone-marrow-aspirate-for-mandibular-condylar-reconstruction
#20
Debraj Howlader, U Vignesh, Dichen P Bhutia, Rahul Pandey, Sumit Kumar, Tulika Chandra, Divya Mehrotra
PURPOSE: This study was designed with the aim to assess the efficiency of hydroxyapatite/collagen (HA/Col) bio-scaffold with bone marrow aspirate (BMA) to reconstruct mandibular condyle in patients with temporomandibular joint (TMJ) ankylosis. MATERIALS AND METHODS: Seven pediatric patients with TMJ ankylosis, who visited our outpatient clinic and whose parents opted for this procedure, were included in this study. After a history and clinical examination for TMJ movements, computed tomography (CT) scans were obtained...
September 2017: Journal of Cranio-maxillo-facial Surgery
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