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https://www.readbyqxmd.com/read/29691811/chemico-calorimetric-analysis-of-amorphous-granules-manufactured-via-continuous-granulation-process
#1
Mridul Majumder, Saeid Rajabnezhad, Ali Nokhodchi, Mohammed Maniruzzaman
The current study explores the first case of the implementation of solution calorimetry (SolCal) in order to determine the amorphous content of crystalline benzoyl-methoxy-methylindol-acetic acid (BMA)-a model poorly soluble drug, in the amorphous granules prepared via single-step continuous twin-screw dry granulations (TSG). Amorphous magnesium aluminometasilicate (Neusilin®) (US2) was used as a novel inorganic carrier via a TwinLab 10 mm twin-screw extruder. The BMA/US2 blends were processed at 180 °C and varying drug: carrier ratios of 1:4, 1:2...
April 24, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29666109/gmc-should-lose-right-to-appeal-fitness-to-practise-decisions-says-bma
#2
Abi Rimmer
No abstract text is available yet for this article.
April 17, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29655936/dynamic-causal-modelling-on-infant-fnirs-data-a-validation-study-on-a-simultaneously-recorded-fnirs-fmri-dataset
#3
Chiara Bulgarelli, Anna Blasi, Simon Arridge, Samuel Powell, Carina de Klerk, Victoria Southgate, Sabrina Brigadoi, William Penny, Sungho Tak, Antonia Hamilton
Tracking the connectivity of the developing brain from infancy through childhood is an area of increasing research interest, and fNIRS provides an ideal method for studying the infant brain as it is compact, safe and robust to motion. However, data analysis methods for fNIRS are still underdeveloped compared to those available for fMRI. Dynamic causal modelling (DCM) is an advanced connectivity technique developed for fMRI data, that aims to estimate the coupling between brain regions and how this might be modulated by changes in experimental conditions...
April 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29615390/bma-registers-interest-in-bawa-garba-s-appeal-against-erasure
#4
Clare Dyer
No abstract text is available yet for this article.
April 3, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29602078/increasing-the-anticancer-performance-of-bufalin-buf-by-introducing-an-endosome-escaping-polymer-and-tumor-targeting-peptide-in-the-design-of-a-polymeric-prodrug
#5
Xiao-Jing Shi, Yan-Yan Qiu, Hui Yu, Cheng Liu, Yu-Xia Yuan, Pei-Hao Yin, Tao Liu
A well-defined multifunctional brush-type polymeric prodrug covalently linked with an anticancer drug (bufalin, BUF), a tumor-targeting peptide (RGD), and an endosome-escaping polymer, poly(N,N-diethylaminoethyl methacrylate-co-butyl methacrylate (P(DEA-co-BMA)), was developed. Its anticancer performance against colon cancer was investigated in vitro and in vivo. Reversible addition-fragmentation transfer (RAFT) polymerization of oligo(ethylene glycol) monomethyl ether methacrylate (OEGMA), 2-((3-(tert-butoxy)-3-oxopropyl)thio)ethyl methacrylate (BSTMA), and 2-(2-bromoisobutyryloxy)ethylmethacrylate (BIEM) afforded the multifunctional random copolymer, P(OEGMA-co-BSTMA-co-BIEM), in which hydrophilic POEGMA can stabilize nanoparticles in water, PBSTMA can be converted into carboxyl groups, and PBIEM can be employed as a macromolecular atom radical transfer polymerization (ATRP) initiator...
March 19, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29599267/maintain-funding-to-cover-gps-indemnity-costs-says-bma
#6
Abi Rimmer
No abstract text is available yet for this article.
March 29, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29582606/-preparation-of-monolithic-fibers-with-deep-eutectic-solvent-for-solid-phase-microextraction-of-polycyclic-aromatic-hydrocarbons-in-lake-water
#7
Na Chen, Yijun Zhang, Wanli Zhao, Jun Chen, Yuping Zhang
A monolithic fiber of poly(butyl methacrylate-ethylene glycol dimethacrylate)[poly(BMA-EDMA)] was prepared using deep eutectic solvent (DES) of choline chloride-ethanediol as a porogen. The prepared fibers were applied to direct extraction of three polycyclic aromatic hydrocarbons (PAHs) in lake water samples by solid phase microextraction (SPME). The extracts were determined by ultra performance liquid chromatography (UPLC). The fiber without DES was prepared at the same time. Both fibers (with and without DES) were compared with a commercial polydimethylsiloxane (PDMS) fiber...
January 8, 2018: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29581471/using-spatial-mark-recapture-for-conservation-monitoring-of-grizzly-bear-populations-in-alberta
#8
John Boulanger, Scott E Nielsen, Gordon B Stenhouse
One of the challenges in conservation is determining patterns and responses in population density and distribution as it relates to habitat and changes in anthropogenic activities. We applied spatially explicit capture recapture (SECR) methods, combined with density surface modelling from five grizzly bear (Ursus arctos) management areas (BMAs) in Alberta, Canada, to assess SECR methods and to explore factors influencing bear distribution. Here we used models of grizzly bear habitat and mortality risk to test local density associations using density surface modelling...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29572357/bma-and-government-reach-agreement-on-doctors-bonus-scheme
#9
Abi Rimmer
No abstract text is available yet for this article.
March 23, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29549079/bma-urges-government-to-reverse-public-health-cuts
#10
Gareth Iacobucci
No abstract text is available yet for this article.
March 16, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29547459/biological-rationale-for-the-use-of-vertebral-whole-bone-marrow-in-spinal-surgery
#11
Francesca Salamanna, Simona Cepollaro, Deyanira Contartese, Gianluca Giavaresi, Giovanni Barbanti Brodano, Cristiana Griffoni, Alessandro Gasbarrini, Milena Fini
STUDY DESIGN: Laboratory study. OBJECTIVE: Mesenchymal stem cells (MSCs) derived from whole bone marrow aspirate (BMA) and MSCs derived from density-gradient centrifugation were isolated from vertebral bodies and cultured under either hypoxic or normoxic conditions to evaluate their biological characteristics and HOX and TALE signature able to improve spinal surgery procedures. SUMMARY OF BACKGROUND DATA: The use of spinal fusion procedures has increased over the last decades; however, failed fusion still remains an important problem...
March 15, 2018: Spine
https://www.readbyqxmd.com/read/29540363/bma-is-deeply-concerned-by-35-rise-in-spending-on-private-providers-in-three-years
#12
Jacqui Thornton
No abstract text is available yet for this article.
March 14, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29523581/government-must-introduce-incentives-to-retain-older-gps-says-bma
#13
Abi Rimmer
No abstract text is available yet for this article.
March 9, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29519785/plans-to-restrict-access-to-drugs-will-put-vulnerable-patients-at-risk-bma-argues
#14
Gareth Iacobucci
No abstract text is available yet for this article.
March 8, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29507292/fear-extinction-requires-infralimbic-cortex-projections-to-the-basolateral-amygdala
#15
Daniel W Bloodgood, Jonathan A Sugam, Andrew Holmes, Thomas L Kash
Fear extinction involves the formation of a new memory trace that attenuates fear responses to a conditioned aversive memory, and extinction impairments are implicated in trauma- and stress-related disorders. Previous studies in rodents have found that the infralimbic prefrontal cortex (IL) and its glutamatergic projections to the basolateral amygdala (BLA) and basomedial amygdala (BMA) instruct the formation of fear extinction memories. However, it is unclear whether these pathways are exclusively involved in extinction, or whether other major targets of the IL, such as the nucleus accumbens (NAc) also play a role...
March 6, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29464518/erp-source-analysis-guided-by-fmri-during-familiar-face-processing
#16
Maria A Bobes, Agustin Lage-Castellanos, Ela I Olivares, Jhoanna Perez Hidalgo-Gato, Jaime Iglesias, Ana Maria Castro-Laguardia, Pedro Valdes-Sosa
Event related potentials (ERPs) provide precise temporal information about cognitive processing, but with poor spatial resolution, while functional magnetic resonance imaging (fMRI) reliably identifies brain areas involved, but with poor temporal resolution. Here we use fMRI to guide source localization of the ERPs at different times for studying the temporal dynamics of the neural system for recognizing familiar faces. fMRI activation areas were defined in a previous experiment applying the same paradigm used for ERPs...
February 20, 2018: Brain Topography
https://www.readbyqxmd.com/read/29463503/many-ccgs-are-failing-to-boost-mental-health-funding-bma-warns
#17
Gareth Iacobucci
No abstract text is available yet for this article.
February 20, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29463496/scottish-gps-resign-from-bma-in-protest-at-new-contract
#18
Gareth Iacobucci
No abstract text is available yet for this article.
February 20, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29456240/novel-synthetic-bisindolylmaleimide-alkaloids-inhibit-stat3-activation-by-binding-to-the-sh2-domain-and-suppress-breast-xenograft-tumor-growth
#19
Xia Li, Hongguang Ma, Lin Li, Yifan Chen, Xiao Sun, Zizheng Dong, Jing-Yuan Liu, Weiming Zhu, Jian-Ting Zhang
Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in malignant tumors and plays important roles in multiple aspects of cancer aggressiveness. Thus, targeting STAT3 promises to be an attractive strategy for the treatment of advanced metastatic tumors. Bisindolylmaleimide alkaloid (BMA) has been shown to have anti-cancer activities and was thought to suppress tumor cell growth by inhibiting protein kinase C. In this study, we show that a newly synthesized BMA analog, BMA097, is effective in suppressing tumor cell and xenograft growth and in inducing spontaneous apoptosis...
February 19, 2018: Oncogene
https://www.readbyqxmd.com/read/29449209/don-t-distract-from-true-issues-facing-young-doctors-bma-tells-pay-body
#20
Abi Rimmer
No abstract text is available yet for this article.
February 15, 2018: BMJ: British Medical Journal
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