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https://www.readbyqxmd.com/read/28718394/multiple-possible-inaccuracies-cast-doubt-on-a-recent-report-suggesting-selective-serotonin-reuptake-inhibitors-to-be-toxic-and-ineffective
#1
Fredrik Hieronymus, Alexander Lisinski, Jakob Näslund, Elias Eriksson
According to a systematic review on the use of selective serotonin reuptake inhibitors (SSRIs) in adult depression that was recently published in BMC Psychiatry, the results of which have been widely disseminated in lay media, these drugs increase the risk for serious adverse events (SAEs) while exerting poor antidepressant efficacy. A cursory analysis, however, suggests the analysis of SAEs conducted by the authors to be marred by both methodological inaccuracies and blatant errors. After having corrected for these apparent mistakes, we conducted a sensitivity analysis in which we also accounted for a possible moderating effect of age; while this suggests SSRIs to be safe drugs in the non-elderly, they do confirm what is already known, that is, that they may enhance the risk for SAEs in the old...
July 18, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28712981/judo-practice-in-early-age-promotes-high-level-of-bone-mass-acquisition-of-growing-boys-skeleton
#2
Kawther Missawi, Mohamed Zouch, Hamada Chaari, Yosra Chakroun, Zouhair Tabka, Elyès Bouajina
The current study aimed to exhibit effects of judo training for at least 2 yr on bone mass parameters in growing boys. Our population was composed of one hundred and thirty boys in tanner stage 1 and aged 10.52 ± 0.86 yr. Eleven judo players were therefore, excluded from the study because they do not have participate regularly to the judo training sessions during the last 2 yr. The resting sample was divided into two groups: 50 judo players (JU group) and 69 controls (C group). Bone mineral density (BMD), bone mineral content (BMC), and bone area (BA) were evaluated by using dual-photon X-ray absorptiometry on weight-bearing sites: the whole body, lumbar spine (L2-L4), legs, femoral necks and hips and on the non-weight bearing sites: arms and radiuses...
July 13, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28711659/exercise-initiated-after-the-onset-of-insulin-resistance-improves-trabecular-microarchitecture-and-cortical-bone-biomechanics-of-the-tibia-in-hyperphagic-otsuka-long-evans-tokushima-fatty-rats
#3
Laura C Ortinau, Melissa A Linden, Rebecca K Dirkes, R Scott Rector, Pamela S Hinton
The present study extends our previous findings that exercise, which prevents the onset of insulin resistance and type 2 diabetes (T2D), also prevents the detrimental effects of T2D on whole-bone and tissue-level strength. Our objective was to determine whether exercise improves bone's structural and material properties if insulin resistance is already present in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The OLETF rat is hyperphagic due to a loss-of-function mutation in cholecystokinin-1 receptor (CCK-1 receptor), which leads to progressive obesity, insulin resistance and T2D after the majority of skeletal growth is complete...
July 12, 2017: Bone
https://www.readbyqxmd.com/read/28709981/relative-toxicity-for-indoor-semi-volatile-organic-compounds-based-on-neuronal-death
#4
Kevin Fournier, Emmanuel Baumont, Philippe Glorennec, Nathalie Bonvallot
BACKGROUND: Semi Volatile Organic Compounds (SVOCs) are contaminants commonly found in dwellings as a result of their use as plasticizers, flame retardants, or pesticides in building materials and consumer products. Many SVOCs are suspected of being neurotoxic, based on mammal experimentation (impairment of locomotor activity, spatial learning/memory or behavioral changes), raising the question of cumulative risk assessment. The aim of this work is to estimate the relative toxicity of such SVOCs, based on neuronal death...
July 11, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28709408/erratum-to-screening-for-chronic-kidney-disease-of-uncertain-aetiology-in-sri-lanka-usability-of-surrogate-biomarkers-over-dipstick-proteinuria
#5
(no author information available yet)
No abstract text is available yet for this article.
July 14, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28708710/bone-accrual-in-children-and-adolescent-nonelite-swimmers-a-2-year-longitudinal-study
#6
Andy C Collins, Kenneth D Ward, Barbara S McClanahan, Deborah L Slawson, Christopher Vukadinovich, Kamra E Mays, Nancy Wilson, George Relyea
OBJECTIVE: To examine differences in bone mass between children and adolescents swimming competitively at nonelite levels (locally and regionally) and nonathletes and to assess changes in bone mass in these 2 groups over 24 months after taking into consideration several known confounders of bone mass. DESIGN: Observational prospective study. PARTICIPANTS: White nonelite swimmers (n = 128) and nonathletes (n = 106) 8 to 18 years of age from Memphis, Tennessee, USA...
July 11, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28701179/a-study-on-relationship-between-elderly-sarcopenia-and-inflammatory-factors-il-6-and-tnf-%C3%AE
#7
Ai-Lin Bian, Hui-Ying Hu, Yu-Dong Rong, Jian Wang, Jun-Xiong Wang, Xin-Zi Zhou
BACKGROUND: This report aims to study the relationship between sarcopenia of elderly in community and inflammatory factors IL-6 and TNF-α. METHODS: A total of 441 elders who undertook physical examinations were included into this study. The age of these subjects were >60, in which 235 subjects were male and 206 subjects were female. According to the diagnostic standards of sarcopenia set by EWGSOP and AWGS, these subjects were divided into two groups: sarcopenia, and non-sarcopenia groups...
July 12, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28686536/dietary-protein-intake-above-the-current-rda-and-bone-health-a-systematic-review-and-meta-analysis
#8
Taylor C Wallace, Cara L Frankenfeld
Dietary intake of protein is fundamental for optimal acquisition and maintenance of bone across all life stages; however, it has been hypothesized that intakes above the current recommended dietary allowance (RDA) might be beneficial for bone health. We utilized the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines when preparing and reporting this systematic review and meta-analysis. A literature search strategy through April 11, 2017, was developed for the following 3 databases: PubMed, Ovid Medline, and Agricola...
July 7, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28686309/absence-of-calcitriol-causes-increased-lactational-bone-loss-and-lower-milk-calcium-but-does-not-impair-post-lactation-bone-recovery-in-cyp27b1-null-mice
#9
Brittany R Gillies, Brittany A Ryan, Brett A Tonkin, Ingrid J Poulton, Yue Ma, Beth J Kirby, René St-Arnaud, Natalie A Sims, Christopher S Kovacs
We hypothesized that adaptation to calcium supply demands of pregnancy and lactation do not require calcitriol. Adult Cyp27b1 null mice lack calcitriol and have hypocalcemia, hypophosphatemia, and rickets. We studied wild-type (WT) and null sister pairs raised on a calcium, phosphorus and lactose-enriched "rescue" diet that prevents hypocalcemia and rickets. Bone mineral content (BMC) increased >30% in pregnant nulls, declined 30% during lactation, and increased 30% by 4 weeks post-weaning. WT showed less marked changes...
July 7, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28685886/longitudinal-adaptations-of-bone-mass-geometry-and-metabolism-in-adolescent-male-athletes-the-pro-bone-study
#10
Dimitris Vlachopoulos, Alan R Barker, Esther Ubago-Guisado, Ioannis G Fatouros, Karen M Knapp, Craig A Williams, Luis Gracia-Marco
Adolescence is a crucial period for bone development and exercise can enhance bone acquisition during this period of life. However, it is not known how the different loading sports practised can affect bone acquisition in adolescent male athletes. Therefore, the purpose of the present study was to determine the 1 year longitudinal bone acquisition among adolescent males involved in osteogenic (football) and non-osteogenic sports (swimming and cycling) and compared to active controls. 116 adolescent males aged 12-14 years at baseline were monitored 1 year: 37 swimmers, 37 footballers, 29 cyclists and 14 active controls...
July 7, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28678833/bone-mass-of-female-dance-students-prior-to-professional-dance-training-a-cross-sectional-study
#11
Tânia Amorim, George S Metsios, Matthew Wyon, Alan M Nevill, Andreas D Flouris, José Maia, Eduardo Teixeira, José Carlos Machado, Franklim Marques, Yiannis Koutedakis
BACKGROUND: Professional dancers are at risk of developing low bone mineral density (BMD). However, whether low BMD phenotypes already exist in pre-vocational dance students is relatively unknown. AIM: To cross-sectionally assess bone mass parameters in female dance students selected for professional dance training (first year vocational dance students) in relation to aged- and sex-matched controls. METHODS: 34 female selected for professional dance training (10...
2017: PloS One
https://www.readbyqxmd.com/read/28674855/carnosic-acid-attenuates-rankl-induced-oxidative-stress-and-osteoclastogenesis-via-induction-of-nrf2-and-suppression-of-nf-%C3%AE%C2%BAb-and-mapk-signalling
#12
Dinesh Thummuri, V G M Naidu, Pradip Chaudhari
Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor, which plays an important role in the cellular defense against oxidative stress by induction of anti-oxidant and cytoprotective enzymes. In the current study, we sought to investigate the osteoprotective effect of carnosic acid (CA), a phenolic (catecholic) diterpene. It is widely identified for its electrophilic nature under oxidative stress conditions and thus anticipated to counter osteoporosis by facilitation of Nrf2 signalling...
July 4, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28673521/addiction-consultation-services-linking-hospitalized-patients-to-outpatient-addiction-treatment
#13
Paul Trowbridge, Zoe M Weinstein, Todd Kerensky, Payel Roy, Danny Regan, Jeffrey H Samet, Alexander Y Walley
BACKGROUND: Approximately 15% of hospitalized patients have an active substance use disorder (SUD). Starting treatment for SUD, including medications, during acute hospitalizations can engage patients in addiction care. In July 2015, the Boston Medical Center Addiction Consult Service (ACS), began providing inpatient diagnostic, management, and discharge linkage consultations. We describe this implementation. METHODS: The ACS staff recorded SUDs diagnoses and medication recommendations and tracked follow-up data for affiliated outpatient office-based addiction clinics and methadone maintenance programs...
August 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28672287/association-between-linear-growth-and-bone-accrual-in-a-diverse-cohort-of-children-and-adolescents
#14
Shana E McCormack, Diana L Cousminer, Alessandra Chesi, Jonathan A Mitchell, Sani M Roy, Heidi J Kalkwarf, Joan M Lappe, Vicente Gilsanz, Sharon E Oberfield, John A Shepherd, Karen K Winer, Andrea Kelly, Struan F A Grant, Babette S Zemel
Importance: Prevention of osteoporosis in adulthood begins with optimizing bone health in early life. The longitudinal association between growth and bone accretion during childhood is not fully understood. Objectives: To assess the acquisition of whole-body (WB) and skeletal site-specific bone mineral content (BMC) relative to linear growth in a healthy, diverse, longitudinal cohort of children, adolescents, and young adults and to test for differences related to sex and African American race...
July 3, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28670535/effect-of-antithyroid-therapies-on-bone-and-body-composition-a-prospective-randomized-clinical-study-comparing-antithyroid-drugs-with-radioiodine-therapy
#15
Shekhar Kansara, Narendra Kotwal, K V S Hari Kumar, Yashpal Singh, Vimal Upreti, Amit Nachankar
BACKGROUND: Thyrotoxicosis is associated with loss of body weight and bone mineral content (BMC). Antithyroid drugs (ATD) and radioiodine therapy (RIT) are the common options for the management of thyrotoxicosis. We evaluated the effect of ATD and RIT on BMC and body composition. MATERIALS AND METHODS: In this prospective study, we randomized 60 patients of thyrotoxicosis (20-50 years, treatment naïve, males) to receive either ATD (Group 1) using carbimazole or RIT (Group 2)...
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28663856/early-biomarker-for-radiation-induced-wounds-day-one-post-irradiation-assessment-using-hemoglobin-concentration-measured-from-diffuse-optical-reflectance-spectroscopy
#16
Lee C L Chin, Elina K Cook, Darren Yohan, Anthony Kim, Carolyn Niu, Brian C Wilson, Stanley K Liu
Normal tissue radiation toxicities are evaluated subjectively and cannot predict the development of severe side-effects. Using a hand-held diffuse reflectance optical spectroscopy probe, we measured optical parameters in mouse skin 1-4 days after irradiation. Using a radiation toxicity model and a therapeutic mitigator described previously [BMC Cancer14, 614 (2014)], we found that hemoglobin (Hb) levels increased sharply 24 h after irradiation only in the irradiated group without the mitigator. This group also had the largest peak wound areas after 14 days...
March 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28657185/patterns-of-use-and-toxicity-of-new-para-halogenated-substituted-cathinones-4-cmc-clephedrone-4-cec-4-chloroethcatinone-and-4-bmc-brephedrone
#17
Marc Grifell, Mireia Ventura, Xoán Carbón, Pol Quintana, Liliana Galindo, Álvaro Palma, Ivan Fornis, Cristina Gil, Magi Farre, Marta Torrens
OBJECTIVE: This paper aims to present results of the analysis of clephedrone (4-CMC), 4-chloroethcathinone (4-CEC), and brephedrone (4-BMC) on recreational drug markets and a systematic review of all the available information concerning these substances. MATERIAL AND METHODS: Samples collected by the drug checking service of the Spanish harm reduction NGO-Energy Control were analyzed and systematic research was conducted. Between June 2014 and October 2016, 1,471 samples with at least one NPS were analyzed, 397 of which contained cathinones...
May 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28645697/clinical-high-resolution-mapping-of-the-proteoglycan-bound-water-fraction-in-articular-cartilage-of-the-human-knee-joint
#18
Mustapha Bouhrara, David A Reiter, Kyle W Sexton, Christopher M Bergeron, Linda M Zukley, Richard G Spencer
PURPOSE: We applied our recently introduced Bayesian analytic method to achieve clinically-feasible in-vivo mapping of the proteoglycan water fraction (PgWF) of human knee cartilage with improved spatial resolution and stability as compared to existing methods. MATERIALS AND METHODS: Multicomponent driven equilibrium single-pulse observation of T1 and T2 (mcDESPOT) datasets were acquired from the knees of two healthy young subjects and one older subject with previous knee injury...
June 20, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28642655/the-influence-of-passive-tobacco-exposure-and-physical-exercise-on-bone-tissue-of-young-rats
#19
Regina Celi Trindade Camargo, Regiane Rocha Costalonga, Mário Jefferson Quirino Louzada, Rômulo Araújo Fernandes, José Carlos Silva Camargo, Jacqueline Bexiga Urban
OBJECTIVE: The objective of this study is to investigate the effect of passive smoking during pregnancy and associated with swimming on bone area growth, bone mineral density (BMD), and bone mineral content (BMC). METHODS: The offspring was grouped by control matrices (G1) and passive smokers (G2). The offspring was regrouped in eight subgroups, with exposure to smoking (2x/day) and physical exercise (1 session/day), respecting the group of matrices in: sedentary control (G1CS and G2CS), swimming control (G1CN and G2CN), sedentary passive smoker (G1FS and G2FS), and passive smoker swimmer (G1FN and G2FN)...
March 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28639702/bone-marrow-aspirate-clot-a-technical-complication-or-a-smart-approach-for-musculoskeletal-tissue-regeneration
#20
REVIEW
F Salamanna, D Contartese, N Nicoli Aldini, G Barbanti Brodano, C Griffoni, A Gasbarrini, M Fini
One of the methods employed to improve healing of damaged tissues is the use of cellular based therapies. A number of regenerative medicine based strategies, from in vitro expanded mesenchymal stem cells (MSCs) to "one-step" procedures using bone marrow (BM) in toto (BM aspirate; BMA) or BM concentrate (BMC), have been developed. Recently, orthopedic researchers focused their attention on the clinical therapeutic potential of BMC and BMA for musculoskeletal regeneration. BMA is reported as an excellent source of cells and growth factors...
June 22, 2017: Journal of Cellular Physiology
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