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https://www.readbyqxmd.com/read/28095920/accuracy-of-who-immunological-criteria-in-identifying-virological-failure-among-hiv-infected-adults-on-first-line-antiretroviral-therapy-in-mwanza-north-western-tanzania
#1
Daniel W Gunda, Benson R Kidenya, Stephen E Mshana, Semvua B Kilonzo, Bonaventura C T Mpondo
BACKGROUND: Optimal HIV treatment monitoring remains a big challenge in resource limited settings. Guidelines recommend the use of clinical and immunological criteria in resource limited settings due to unavailability of viral load monitoring; however their utility is questionable. This study aimed at assessing the accuracy of immunological criteria in detecting treatment failure among HIV infected Tanzanian adults receiving first line ART. METHODS: A clinic based cross sectional study was conducted between February and July 2011 at Bugando Medical centre (BMC) HIV care and treatment clinic (CTC) involving HIV infected patients aged 18 years and above, receiving first line ART; followed up for at least 1 year...
January 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28077378/peripheral-skeleton-bone-strength-is-positively-correlated-with-total-and-dairy-protein-intakes-in-healthy-postmenopausal-women
#2
Claire Durosier-Izart, Emmanuel Biver, Fanny Merminod, Bert van Rietbergen, Thierry Chevalley, François R Herrmann, Serge L Ferrari, René Rizzoli
BACKGROUND: Bone mineral content (BMC) and bone mineral density (BMD) are positively correlated with dietary protein intakes, which account for 1-8% of BMC and BMD variances. However, the relation between bone strength and microstructure, which are variables that are not captured by areal bone mineral density (aBMD), and dietary protein intakes, particularly from specific dietary sources, has not been clearly established. OBJECTIVE: We investigated the association between the peripheral skeleton-predicted failure load and stiffness, bone microstructure, and dietary protein intakes from various origins (animal, divided into dairy and nondairy, and vegetable origins) in healthy postmenopausal women...
January 11, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28074252/high-dietary-sodium-intake-is-associated-with-low-bone-mass-in-postmenopausal-women-korea-national-health-and-nutrition-examination-survey-2008-2011
#3
S-J Kwon, Y-C Ha, Y Park
: The present cross-sectional study performed using data from the Korea National Health and Nutrition Examination Survey in 9526 women older than 18 years of age demonstrates that high sodium intake is associated with lower bone mineral density and sodium intake ≥2000 mg/day is a risk factor for osteoporosis in postmenopausal women. INTRODUCTION: Several studies have reported that large amount of dietary sodium intake is highly associated with elevated urinary calcium...
January 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28070986/predicting-severity-of-disease-causing-variants
#4
Abhishek Niroula, Mauno Vihinen
Most diseases, including those of genetic origin, express a continuum of severity. Clinical interventions for numerous diseases are based on the severity of the phenotype. Predicting severity due to genetic variants could facilitate diagnosis and choice of therapy. Although computational predictions have been used as evidence for classifying the disease-relevance of genetic variants, special tools for predicting disease severity in large scale are missing. Here, we manually curated a dataset containing variants leading to severe and less severe phenotypes and studied the abilities of variation impact predictors to distinguish between them...
January 9, 2017: Human Mutation
https://www.readbyqxmd.com/read/28052241/modeling-dynamics-and-function-of-bone-marrow-cells-in-mouse-liver-regeneration
#5
Elisa Pedone, Vlad-Aris Olteanu, Lucia Marucci, Maria Isabel Muñoz-Martin, Sameh A Youssef, Alain de Bruin, Maria Pia Cosma
In rodents and humans, the liver can efficiently restore its mass after hepatectomy. This is largely attributed to the proliferation and cell cycle re-entry of hepatocytes. On the other hand, bone marrow cells (BMCs) migrate into the liver after resection. Here, we find that a block of BMC recruitment into the liver severely impairs its regeneration after the surgery. Mobilized hematopoietic stem and progenitor cells (HSPCs) in the resected liver can fuse with hepatocytes, and the hybrids proliferate earlier than the hepatocytes...
January 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28047327/su-f-t-279-impact-of-beam-energy-drifts-on-imrt-delivery-accuracy
#6
S Goddu, G Kamal, A Herman, S Edwards, S Yaddanapudi, S Oddiraju, B Cai, D Rangaraj, S Mutic
PURPOSE: According to TG-40 percent-depth-dose (PDD) tolerance is ±2% but TG-142 is ±1%. Now the question is, which one is relevant in IMRT era? The primary objective of this study is to evaluate dosimetric impact of beam-energy-drifts on IMRT-delivery. METHODS: Beam-energy drifts were simulated by adjusting Linac's bending-magnet-current (BMC) followed by tuning the pulse-forming network and adjusting gun-current. PDD change of -0.6% and +1.2% were tested. Planar-dosimetry measurements were performed using an ionization-chamber-array in solid-water phantoms...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046868/su-g-tep1-10-predicting-photon-percentage-depth-dose-from-profile-due-to-changes-in-beam-quality
#7
S Lebron, D Kahler, C Liu
PURPOSE: To predict photon percentage depth dose (PDD) from profile due to a change in flattened (FF) and flattening-filter-free (FFF) beam quality. METHODS: 6MV photon beam PDDs and profiles in a 3D water tank (3DW) and profiles in an ionization chamber array (ICP) were collected for different field sizes and depths with FF and FFF beams in a Versa HD (Elekta Ltd.). The energy was adjusted by changing the bending magnet current (BMC) ±15% from the clinical beam (6MV) in 5% increments...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28034589/bone-variables-in-active-overweight-obese-men-and-sedentary-overweight-obese-men
#8
Georges El Khoury, Hassane Zouhal, Geneviève Cabagno, César El Khoury, Maroun Rizkallah, Ghassan Maalouf, Rawad El Hage
The aim of this study was to compare bone variables in active overweight/obese men and sedentary overweight/obese men. Thirty-seven active overweight/obese men and 45 sedentary overweight/obese men participated in this study. Weight and height were measured, and body mass index was calculated. Body composition and bone variables (bone mineral content [BMC], bone mineral density [BMD], geometric indices of hip bone strength, and trabecular bone score) were measured by DXA. Physical activity level, daily calcium intake, daily protein intake, and sleep duration were measured by validated questionnaires...
December 26, 2016: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28017952/-effect-of-exercise-and-sports-activity-on-bone-health-during-the-period-of-adolescence-to-young-adulthood
#9
Takeru Kato
Physical activity may play an important role in maximizing bone mass during adolescence to young adulthood and may have long-lasting benefits on bone health. Because peak bone mass is thought to be attained by the end of the third decade, the early adult years may be the final opportunity for its augmentation. High-impact weight-bearing exercise during youth may provide lifelong benefits in terms of bone mineral content, structure and strength, and consequently reduce fracture risk. Weight-bearing exercise in youth affects bone, and these effects may be preserved as BMC, geometric and structural advantages even after 40 years...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28017941/-a-role-of-exercise-and-sports-in-the-prevention-of-osteoporosis
#10
Jun Iwamoto
Physical activity plays an important role in maintaining or enhancing bone health. Jumping exercise increases bone mineral content(BMC)in prepubescent children(premenarcheal girls). Bone mineral density(BMD)is higher in adolescent athletes who are engaged in weight-bearing activities. Jumping exercise, muscle strengthening exercise, and weight-bearing plus muscle strengthening exercises increase BMD in young adults and premenopausal women. Walking, aerobic weight-bearing exercise, muscle strengthening exercise, and weight-bearing plus muscle strengthening exercises maintain or increase BMD in postmenopausal women...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28013361/bone-mass-and-strength-are-significantly-improved-in-mice-overexpressing-human-wnt16-in-osteocytes
#11
Imranul Alam, Austin M Reilly, Mohammed Alkhouli, Rita L Gerard-O'Riley, Charishma Kasipathi, Dana K Oakes, Weston B Wright, Dena Acton, Amie K McQueen, Bhavmik Patel, Kyung-Eun Lim, Alexander G Robling, Michael J Econs
Recently, we demonstrated that osteoblast-specific overexpression of human WNT16 increased both cortical and trabecular bone mass and structure in mice. To further identify the cell-specific role of Wnt16 in bone homeostasis, we created transgenic (TG) mice overexpressing human WNT16 in osteocytes using Dmp1 promoter (Dmp1-hWNT16 TG) on C57BL/6 (B6) background. We analyzed bone phenotypes and serum bone biomarkers, performed gene expression analysis and measured dynamic bone histomorphometry in Dmp1-hWNT16 TG and wild-type (WT) mice...
December 24, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/28012889/analysis-of-risk-factors-for-secondary-new-vertebral-compression-fracture-following-percutaneous-vertebroplasty-in-patients-with-osteoporosis
#12
Jung Sik Bae, Jeong Hyun Park, Ki Joon Kim, Hyeun Sung Kim, Il-Tae Jang
OBJECTIVE: To analyze the risk factors for secondary new vertebral compression fracture(SNVCF) following percutaneous vertebroplasty in patients with osteoporosis. MATERIALS AND METHODS: We investigated medical records and radiologic images from patients receiving percutaneous vertebroplasty(PV) due to osteoporotic vertebral compression fracture, between October 2009 and September 2014. We checked patients' age, past medical history and bone mineral content(BMC) using computed tomogram(CT)...
December 21, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/28005635/longitudinal-body-composition-changes-in-ncaa-division-i-college-football-players
#13
Eric T Trexler, Abbie E Smith-Ryan, J Bryan Mann, Pat A Ivey, Katie R Hirsch, Meredith G Mock
Trexler, ET, Smith-Ryan, AE, Mann, JB, Ivey, PA, Hirsch, KR, and Mock, MG. Longitudinal body composition changes in NCAA Division I college football players. J Strength Cond Res 31(1): 1-8, 2017-Many athletes seek to optimize body composition to fit the physical demands of their sport. American football requires a unique combination of size, speed, and power. The purpose of the current study was to evaluate longitudinal changes in body composition in Division I collegiate football players. For 57 players (mean ± SD, age = 19...
January 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28003538/whey-protein-supplementation-and-higher-total-protein-intake-do-not-influence-bone-quantity-in-overweight-and-obese-adults-following-a-36-wk-exercise-and-diet-intervention
#14
Christian S Wright, Aoibheann M McMorrow, Eileen M Weinheimer-Haus, Wayne W Campbell
BACKGROUND: Controversy exists concerning the effects of higher total protein intake (TPro) on bone health, which may be associated with reduced bone mineral density (BMD). However, whey protein (WP) may induce bone formation because of its basic component, milk basic protein. OBJECTIVE: This study assessed the effects of WP supplementation, TPro, and change in TPro (postsupplementation - presupplementation) on BMD and bone mineral content (BMC; total body, lumbar spine, total femur, and femoral neck) in overweight and class I obese middle-aged adults following an exercise intervention...
December 21, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/28002915/autologous-bone-marrow-concentrate-combined-with-platelet-rich-plasma-enhance-bone-allograft-potential-to-induce-spinal-fusion
#15
G Vadalà, A Di Martino, F Russo, M C Tirindelli, L De Felice, F Agostini, R Papalia, V Denaro
Bone marrow cells concentrate (BMCs) is a source of osteoprogenitor cells and platelet-rich plasma (PRP) is a source of growth factors. The objective of the study was to determine whether BMC and PRP could increase the potential of bone allograft to induce posterolateral-lumbar spinal fusion compared to the bone allograft alone. A prospective nonrandomized radiographic study has been conduced on 10 patients with posterolateral instrumented fusion for degenerative lumbar disease with 1-year follow-up using CT scan...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28002902/bone-marrow-concentrated-cells-and-stromal-vascular-fraction-cells-injections-for-osteoarthritis-treatment-a-systematic-review
#16
G Vadalà, R Papalia, L La Verde, F Russo, V Denaro, M A Rosa
The aim of this systematic review is to examine current clinical evidences supporting the intraarticular injection of bone marrow concentrate cells (BMC) and adipose-derived stromal vascular fraction cells (SVF) for the treatment of osteoarthritis (OA). The research was performed on PubMed (Medline), EMBASE and Cochrane Library considering the English literature. Only clinical trials have been included. The systematic research identified twelve clinical trials. Articles included in the study, were one of level II, four of level III, six of level IV and one level V...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27999850/omega-3-fatty-acids-and-vitamin-d-in-immobilisation-part-a-modulation-of-appendicular-mass-content-composition-and-structure
#17
E L Bostock, C I Morse, K Winwood, I M McEwan, G L Onambélé
OBJECTIVES: Muscle size decreases in response to short-term limb immobilisation. This study set out to determine whether two potential protein-sparing modulators (eicosapentaenoic acid and vitamin D) would attenuate immobilisation-induced changes in muscle characteristics. DESIGN: The study used a randomised, double-blind, placebo-controlled design. SETTING: The study took part in a laboratory setting. PARTICIPANTS: Twenty-four male and female healthy participants, aged 23...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27984432/incidence-of-a-bifid-mandibular-condyle-in-dry-mandibles
#18
Silviya Yanakieva Nikolova, Diana Hristova Toneva, Nikolai Elenkov Lazarov
BACKGROUND: A bifid mandibular condyle (BMC) is a rare anatomical variation with an etiology not fully understood. Although there are numerous case reports regarding it, purposeful epidemiological investigations on the BMC frequency among different groups are scarce. This study aims to investigate the incidence and laterality of BMC among series of adult males from Bulgaria and perform a morphometric analysis of it. MATERIALS AND METHODS: A series of 500 dry intact mandibles from adult males was investigated...
December 14, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27964724/antimicrobial-resistance-pattern-a-report-of-microbiological-cultures-at-a-tertiary-hospital-in-tanzania
#19
Nyambura Moremi, Heike Claus, Stephen E Mshana
BACKGROUND: Antimicrobial resistance has been declared by the World Health Organization as a threat to the public health. The aim of this study was to analyze antimicrobial resistance patterns of the common pathogens occurring at the Bugando Medical Centre (BMC), Mwanza, Tanzania to provide data for antimicrobial stewardship programmes. METHODS: A total of 3330 microbiological culture results scripts representing non-repetitive specimens reported between June 2013 and May 2015 were retrieved and analyzed for pathogens and their susceptibility patterns using STATA-11 software...
December 13, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27943601/surgical-repair-of-annulus-defect-with-biomimetic-multilamellar-nano-microfibrous-scaffold-in-a-porcine-model
#20
R Kang, H Li, Z Xi, S Ringgard, A Baatrup, K Rickers, M Sun, D Q S Le, M Wang, L Xie, Y Xie, M Chen, C Bünger
Annulus defect is associated with reherniation and disc degeneration after discectomy; currently there is no effective treatment that addresses this problem. The annulus is a hierarchical lamellar structure, where each lamella consists of aligned collagen fibers, which are parallel and tilted at 30° to the spinal axis. In this study, a biomimetic biodegradable scaffold consisting multi-lamella nano/microfibers, sharing nano-topography and micro-porosity similar to the native lamellar structure, was assessed in a porcine model, aided by sealing with fascia and medical glue and subsequent suture fixation...
December 11, 2016: Journal of Tissue Engineering and Regenerative Medicine
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