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https://www.readbyqxmd.com/read/28645697/clinical-high-resolution-mapping-of-the-proteoglycan-bound-water-fraction-in-articular-cartilage-of-the-human-knee-joint
#1
Mustapha Bouhrara, David A Reiter, Kyle W Sexton, Christopher M Bergeron, Linda M Zukley, Richard G Spencer
PURPOSE: We applied a recently introduced method to achieve clinically-feasible in-vivo mapping of the proteoglycan water fraction (PgWF) of human knee cartilage with improved spatial resolution and stability as compared to existing methods. MATERIAL AND METHODS: Multicomponent driven equilibrium single-pulse observation of T1 and T2 (mcDESPOT) datasets were acquired from the knees of two healthy young subjects and one older subject with previous knee injury. Each dataset was processed using Bayesian Monte Carlo (BMC) analysis incorporating a two-component tissue model...
June 20, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28642655/the-influence-of-passive-tobacco-exposure-and-physical-exercise-on-bone-tissue-of-young-rats
#2
Regina Celi Trindade Camargo, Regiane Rocha Costalonga, Mário Jefferson Quirino Louzada, Rômulo Araújo Fernandes, José Carlos Silva Camargo, Jacqueline Bexiga Urban
OBJECTIVE: The objective of this study is to investigate the effect of passive smoking during pregnancy and associated with swimming on bone area growth, bone mineral density (BMD), and bone mineral content (BMC). METHODS: The offspring was grouped by control matrices (G1) and passive smokers (G2). The offspring was regrouped in eight subgroups, with exposure to smoking (2x/day) and physical exercise (1 session/day), respecting the group of matrices in: sedentary control (G1CS and G2CS), swimming control (G1CN and G2CN), sedentary passive smoker (G1FS and G2FS), and passive smoker swimmer (G1FN and G2FN)...
March 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28639702/bone-marrow-aspirate-clot-a-technical-complication-or-a-smart-approach-for-musculoskeletal-tissue-regeneration
#3
REVIEW
F Salamanna, D Contartese, N Nicoli Aldini, G Barbanti Brodano, C Griffoni, A Gasbarrini, M Fini
One of the methods employed to improve healing of damaged tissues is the use of cellular based therapies. A number of regenerative medicine based strategies, from in vitro expanded mesenchymal stem cells (MSCs) to "one-step" procedures using bone marrow (BM) in toto (BM aspirate; BMA) or BM concentrate (BMC), have been developed. Recently, orthopedic researchers focused their attention on the clinical therapeutic potential of BMC and BMA for musculoskeletal regeneration. BMA is reported as an excellent source of cells and growth factors...
June 22, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28638864/protective-effect-of-vanillic-acid-on-ovariectomy-induced-osteoporosis-in-rats
#4
Yong Gui Wang, Liang Bo Jiang, Bo Gou
BACKGROUND: The need for an anti-osteoporotic agent is in high demand since osteoporosis contributes to high rates of disability or impairment (high osteoporotic fracture), morbidity and mortality. Hence, the present study is designed to evaluate the protective effects of vanillic acid (VA) against bilateral ovariectomy-induced osteoporosis in female Sprague-Dawley (SD) rats. MATERIALS AND METHODS: Forty healthy female adult SD rats were separated in to four groups with sham-operated control with bilateral laprotomy (Sham; n = 10), bilateral overiectomy (OVX; n = 10) group, OVX rats were orallay administrated with 50 mg/kg b...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28630697/the-effect-of-position-on-the-precision-of-dual-energy-x-ray-absorptiometry-and-correlation-with-body-condition-score-in-dogs-and-cats
#5
Charlotte R Bjørnvad, Mie E Nielsen, Susanna E M Hansen, Dorte H Nielsen
Dual-energy X-ray absorptiometry (DEXA) has been used to assess body composition in dogs and cats in several studies, but studies are difficult to compare for several reasons. The aim of the present study was to evaluate whether positioning of dogs or cats in either dorsal or ventral recumbency during DEXA scanning influences results. Dogs and cats that were brought to the University Hospital for Companion Animals for euthanasia during the period 15 September-6 November 2015 were consecutively recruited if owners signed a written consent...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28623425/effects-of-a-20-week-high-intensity-strength-and-sprint-training-program-on-tibial-bone-structure-and-strength-in-middle-aged-and-older-male-sprint-athletes-a-randomized-controlled-trial
#6
T H Suominen, M T Korhonen, M Alén, A Heinonen, A Mero, T Törmäkangas, H Suominen
This randomized, controlled, high-intensity strength and sprint training trial in middle-aged and older male sprint athletes showed significant improvements in mid-tibial structure and strength. The study reveals the adaptability of aging bone, suggesting that through a novel, intensive training stimulus it is possible to strengthen bones during aging. INTRODUCTION: High-load, high-speed and impact-type exercise may be an efficient way of improving bone strength even in old age. We evaluated the effects of combined strength and sprint training on indices of bone health in competitive masters athletes, who serve as a group of older people who are likely to be able to participate in vigorous exercise of this kind...
June 16, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28619053/who-needs-registered-reports
#7
EDITORIAL
Miranda Robertson
Registered Reports, an article format initiated to help promote transparency and reproducibility in the preclinical and social sciences, are spreading into the biological literature. The format is now offered by BMC Biology, in a spirit of experiment.
June 15, 2017: BMC Biology
https://www.readbyqxmd.com/read/28608467/discourses-of-joint-commissioning
#8
Ailsa Cameron, Emer Brangan, John Gabbay, Jonathan H Klein, Catherine Pope, Lesley Wye
Increasing attention has focused on the role of joint commissioning in health and social care policy and practice in England. This paper provides an empirical examination of the three discourses of joint commissioning developed from an interpretative analysis of documents by Dickinson et al. (2013; BMC Health Services Research, 13) and applied to data from our study exploring the role of knowledge in commissioning in England. Based on interviews with 92 participants undertaken between 2011 and 2013, our analysis confirms that the three discourses of prevention or empowerment or efficiency are used by professionals from across health and social care organisations to frame their experiences of joint commissioning...
June 12, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28608321/a-comparison-of-principal-component-analysis-partial-least-squares-and-reduced-rank-regressions-in-the-identification-of-dietary-patterns-associated-with-bone-mass-in-ageing-australians
#9
Yohannes Adama Melaku, Tiffany K Gill, Anne W Taylor, Robert Adams, Zumin Shi
PURPOSE: The relative advantages of dietary analysis methods, particularly in identifying dietary patterns associated with bone mass, have not been investigated. We evaluated principal component analysis (PCA), partial least-squares (PLS) and reduced-rank regressions (RRR) in determining dietary patterns associated with bone mass. METHODS: Data from 1182 study participants (45.9% males; aged 50 years and above) from the North West Adelaide Health Study (NWAHS) were used...
June 12, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28592609/tracking-of-vitamin-d-status-from-childhood-to-early-adulthood-and-its-association-with-peak-bone-mass
#10
Kun Zhu, Wendy H Oddy, Patrick Holt, Wendy Chan She Ping-Delfos, Jenny Mountain, Stephen Lye, Craig Pennell, Prue H Hart, John P Walsh
Background: To our knowledge, there are few longitudinal studies of vitamin D status from childhood to early adulthood, and it is uncertain whether vitamin D predicts peak bone mass in young adults.Objectives: The purpose of this longitudinal study was to evaluate the long-term stability of vitamin D status from ages 6 to 20 y in healthy individuals and to study associations between serum 25-hydroxyvitamin D [25(OH)D] at different developmental stages and bone mass measured at age 20 y.Design: Participants were offspring of the Western Australian Pregnancy Cohort (Raine) study...
June 7, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28589417/bone-loss-with-antiepileptic-drug-therapy-a-twin-and-sibling-study
#11
B Shiek Ahmad, S J Petty, A Gorelik, T J O'Brien, K D Hill, J J Christie, P N Sambrook, J D Wark
Changes in areal bone mineral density (aBMD) and other predictors of bone loss were evaluated in 48 same-sex twin/age-matched sibling pairs discordant for antiepileptic drug (AED) use. AED users had reduced BMD at the hip regions. Prolonged AED users had greater aBMD loss, predicting a higher risk of bone fragility. INTRODUCTION: To investigate the longitudinal associations of bone mineral measures with antiepileptic drug (AED) use, including enzyme-inducing (EIAED) and non-enzyme-inducing (NEIAED) types, and other predictors of bone loss in a study of 48 same-sex twin/age-matched sibling pairs (40 female, 8 male) discordant for AED use...
June 6, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28583879/long-term-effects-of-maternal-calcium-supplementation-on-childhood-growth-differ-between-males-and-females-in-a-population-accustomed-to-a-low-calcium-intake
#12
Kate Anna Ward, Landing Jarjou, Ann Prentice
The importance of adequate calcium intakes for healthy growth and bone development has long been recognised. Recent evidence suggests that calcium supplementation may have sex-specific effects on bone growth in childhood. The aim was to describe the long-term effects of calcium supplementation in pregnant Gambian women with a low calcium intake (ISCRTN96502494) on offspring height, weight, bone and body composition in childhood, and whether the effects differ by sex. Children of mothers who participated in the original calcium supplementation trial were measured at age 8-12years using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography...
June 2, 2017: Bone
https://www.readbyqxmd.com/read/28580516/indian-girls-have-higher-bone-mineral-content-per-unit-of-lean-body-than-boys-through-puberty
#13
Anuradha V Khadilkar, Neha Sanwalka, M Zulf Mughal, Shashi Chiplonkar, Vaman Khadilkar
Our aim is to describe changes in the muscle-bone unit assessed as a ratio of bone mineral content (BMC) to lean body mass (LBM) through puberty at total body and various skeletal sites in Indian boys and girls. A cross-sectional study was conducted (888 children, 480 boys, aged 5-17 years) in Pune, India. Pubertal staging was assessed. BMC, LBM and fat percentage at the arms, legs, android, gynoid and total body (less the head) were assessed by dual energy X-ray absorptiometry. The amount of BMC per unit LBM (BMC/LBM) was computed...
June 3, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28580404/the-associations-of-exposure-to-combined-hormonal-contraceptive-use-on-bone-mineral-content-and-areal-bone-mineral-density-accrual-from-adolescence-to-young-adulthood-a-longitudinal-study
#14
Stefan A Jackowski, Adam D G Baxter-Jones, Ashlee J McLardy, Roger A Pierson, Carol D Rodgers
BACKGROUND: The association of long term combined hormone based contraceptives (CHC) use on bone mineral content (BMC) and areal bone mineral density (aBMD) development remains controversial, as it appears that the relationship may be age-dependent. The purpose of this study was to investigate the long-term associations of CHC exposure on the accrual of bone parameters from adolescence into young-adulthood. METHODS: 110 women (67 exposed to CHC) were drawn from the Pediatric Bone Mineral Accrual Study (PBMAS)...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28577285/the-influence-of-birth-weight-and-length-on-bone-mineral-density-and-content-in-adolescence-the-troms%C3%A3-study-fit-futures
#15
Tore Christoffersen, Luai A Ahmed, Anne Kjersti Daltveit, Elaine M Dennison, Elin K Evensen, Anne-Sofie Furberg, Luis Gracia-Marco, Guri Grimnes, Ole-Andreas Nilsen, Berit Schei, Grethe S Tell, Dimitris Vlachopoulous, Anne Winther, Nina Emaus
The influence of birth weight and length on bone mineral parameters in adolescence is unclear. We found a positive association between birth size and bone mineral content, attenuated by lifestyle factors. This highlights the impact of environmental stimuli and lifestyle during growth. PURPOSE: The influence of birth weight and length on bone mineral density and content later in life is unclear, especially in adolescence. This study evaluated the impact of birth weight and length on bone mineral density and content among adolescents...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28571584/spotlight-on-landmark-oncology-trials-the-latest-evidence-and-novel-trial-designs
#16
EDITORIAL
Helena Earl, Stefano Molica, Piotr Rutkowski
The era of precision oncology is marked with prominent successes in the therapy of advanced soft tissue sarcomas, breast cancer, ovarian cancer and haematological neoplasms, among others. Moreover, recent trials of immune checkpoint inhibitors in melanoma, non-small cell lung carcinoma, and head and neck cancers have significantly influenced the therapeutic landscape by providing promising evidence for immunotherapy efficacy in the adjuvant setting in high-risk locoregional disease. To speed up the introduction of targeted therapy for cancer patients, novel phase II trials are being designed, and may likely form the basis for the 'landmark trials' of the future...
June 2, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28561262/quantification-of-regional-variations-in-glenoid-trabecular-bone-architecture-and-mineralization-using-clinical-computed-tomography-images
#17
Bong-Jae Jun, Amit Vasanji, Eric T Ricchetti, Eric Rodriguez, Naveen Subhas, Zong-Ming Li, Joseph P Iannotti
The purpose of this study was to demonstrate feasibility of a clinical CT imaging and analysis technique to quantify regional variations in trabecular bone architecture and mineralization of glenoid bones. Specifically, our objective was to determine to what extent clinical CT imaging of intact upper extremities can describe variations of trabecular bone architectures at anatomic and peri-implant regions by comparing trabecular bone architectures as measured by high-resolution, micro CT imaging of same excised glenoid bones...
May 31, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28549462/development-of-a-snp-panel-dedicated-to-parentage-assignment-in-french-sheep-populations
#18
F Tortereau, C R Moreno, G Tosser-Klopp, B Servin, J Raoul
BACKGROUND: The efficiency of breeding programs partly relies on the accuracy of the estimated breeding values which decreases when pedigrees are incomplete. Two reproduction techniques are mainly used by sheep breeders to identify the sires of lambs: animal insemination and natural matings with a single ram per group of ewes. Both methods have major drawbacks, notably time-consuming tasks for breeders, and are thus used at varying levels in breeding programs. As a consequence, the percentage of known sires can be very low in some breeds and results in less accurate estimated breeding values...
May 26, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28548246/comparison-of-three-different-types-of-scaffolds-preseeded-with-human-bone-marrow-mononuclear-cells-on-the-bone-healing-in-a-femoral-critical-size-defect-model-of-the-athymic-rat
#19
Maren Janko, Julian Sahm, Alexander Schaible, Jan C Brune, Marlene Bellen, Katrin Schröder, Caroline Seebach, Ingo Marzi, Dirk Henrich
Large bone defects often pose major difficulties in orthopedic surgery. The application of long term cultured stem cells combined with a scaffold lead to a significant improvement of bone healing in recent experiments but is strongly restricted by EU-law. Bone marrow mononuclear cells (BMC), however, can be isolated and transplanted within few hours and have been proven effective in experimental models of bone healing. The effectivity of the BMC supported therapy might be influenced by the type of scaffold...
May 26, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28545934/cure-modeling-in-real-time-prediction-how-much-does-it-help
#20
Gui-Shuang Ying, Qiang Zhang, Yu Lan, Yimei Li, Daniel F Heitjan
Various parametric and nonparametric modeling approaches exist for real-time prediction in time-to-event clinical trials. Recently, Chen (2016 BMC Biomedical Research Methodology 16) proposed a prediction method based on parametric cure-mixture modeling, intending to cover those situations where it appears that a non-negligible fraction of subjects is cured. In this article we apply a Weibull cure-mixture model to create predictions, demonstrating the approach in RTOG 0129, a randomized trial in head-and-neck cancer...
May 22, 2017: Contemporary Clinical Trials
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