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https://www.readbyqxmd.com/read/29346436/bone-marrow-concentrate-promotes-bone-regeneration-with-a-suboptimal-dose-of-rhbmp-2
#1
Kazuhiro Egashira, Yoshinori Sumita, Weijian Zhong, Takashi I, Seigo Ohba, Kazuhiro Nagai, Izumi Asahina
Bone marrow concentrate (BMC), which is enriched in mononuclear cells (MNCs) and platelets, has recently attracted the attention of clinicians as a new optional means for bone engineering. We previously reported that the osteoinductive effect of bone morphogenetic protein-2 (BMP-2) could be enhanced synergistically by co-transplantation of peripheral blood (PB)-derived platelet-rich plasma (PRP). This study aims to investigate whether BMC can effectively promote bone formation induced by low-dose BMP-2, thereby reducing the undesirable side-effects of BMP-2, compared to PRP...
2018: PloS One
https://www.readbyqxmd.com/read/29345171/comparison-of-bioelectrical-impedance-analysis-and-dual-energy-x-ray-absorptiometry-for-estimating-bone-mineral-content
#2
Tori M Stone, Jonathan E Wingo, Brett S Nickerson, Michael R Esco
The purpose of this study was to validate single-frequency hand-to-foot bioelectrical impedance analysis (HFBIA) for estimating bone mineral content (BMC) using dual energy X-ray absorptiometry (DXA) as the criterion measure in healthy, men and women aged 18-40 y. A total of 80 men and women participated. Bone mineral content was estimated on the same day using HFBIA and DXA. HFBIA device provided higher mean BMC values in men and the entire sample, but not in women. A smaller standard error of estimate was observed in women (0...
January 18, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29342321/contributions-of-material-properties-and-structure-to-increased-bone-fragility-for-a-given-bone-mass-in-the-ucd-t2dm-rat-model-of-type-2-diabetes
#3
Claire Acevedo, Meghan Sylvia, Eric Schaible, James L Graham, Kimber L Stanhope, Lionel N Metz, Bernd Gludovatz, Ann V Schwartz, Robert O Ritchie, Tamara N Alliston, Peter J Havel, Aaron J Fields
Adults with type 2 diabetes (T2D) have a higher fracture risk for a given bone quantity, but the mechanisms remain unclear. Using a rat model of polygenic obese T2D, we demonstrate that diabetes significantly reduces whole-bone strength for a given bone mass (micro-CT-derived BMC), and we quantify the roles of T2D-induced deficits in material properties versus bone structure, i.e., geometry and microarchitecture. Lumbar vertebrae and ulnae were harvested from 6-month-old lean Sprague-Dawley rats, obese Sprague-Dawley rats, and diabetic obese UCD-T2DM rats (diabetic for 69 ± 7 days; blood glucose >200 mg/dl)...
January 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29342064/minimally-manipulated-bone-marrow-concentrate-compared-with-microfracture-treatment-of-full-thickness-chondral-defects-a-one-year-study-in-an-equine-model
#4
Constance R Chu, Lisa A Fortier, Ashley Williams, Karin A Payne, Taralyn M McCarrel, Megan E Bowers, Diego Jaramillo
BACKGROUND: Microfracture is commonly performed for cartilage repair but usually results in fibrocartilage. Microfracture augmented by autologous bone marrow concentrate (BMC) was previously shown to yield structurally superior cartilage repairs in an equine model compared with microfracture alone. The current study was performed to test the hypothesis that autologous BMC without concomitant microfracture improves cartilage repair compared with microfracture alone. METHODS: Autologous sternal bone marrow aspirate (BMA) was concentrated using a commercial system...
January 17, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29332861/epicardial-fat-thickness-and-bone-mineral-content-the-healthy-twin-study-in-korea
#5
Dong-Won Lee, Min Soo Cho, Eun Yeong Choe, Seung Woo Park, Yun-Mi Song, Sang-Chol Lee, Joohon Sung
BACKGROUND: The conventional concept of positive association between general obesity and bone health was challenged in recent studies reporting the different effects of specific fat deposition on bone health. In the present study, we investigated the association between epicardial fat and bone health. METHODS: We measured echocardiographic epicardial fat thickness (EFT) and bone mineral content (BMC) in a twin-family cohort of Koreans (n = 1,198; 525 men, 460 pre- and 213 post-menopausal women)...
January 13, 2018: Journal of Epidemiology
https://www.readbyqxmd.com/read/29322320/is-there-a-relationship-between-the-load-distribution-on-the-tibial-plateau-and-hip-knee-ankle-angle-after-tka
#6
Takao Kaneko, Norihiko Kono, Yuta Mochizuki, Hiroyasu Ikegami, Yoshiro Musha
INTRODUCTION: This study asked whether differences in coronal alignment after total knee arthroplasty (TKA) affect the load distribution on the tibial plateau. The aim of this study was to investigate the correlation between coronal alignment and the load distribution on the tibial plateau after TKA, using three-dimensional multi-detector-row-computed tomography (3D-MDCT). MATERIALS AND METHODS: In this study, we performed 84 cementless TKA with porous tantalum modular tibial component (PTMT) and divided into three groups based on post-operative hip-knee-ankle (HKA) angle: varus alignment group (n = 22), (176° ≧) neutral alignment group (n = 45), (180° ± 3°), and valgus alignment group (n = 17) (184° ≦)...
January 10, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29302709/sports-participation-in-high-school-and-college-leads-to-high-bone-density-and-greater-rates-of-bone-loss-in-young-men-results-from-a-population-based-study
#7
Maggie M Minett, Lee Weidauer, Howard E Wey, Teresa L Binkley, Tianna M Beare, Bonny L Specker
Estimated lifetime risk of an osteoporotic fracture in men over the age of 50 years is substantial and lifestyle factors such as physical activity may explain variation in bone mass and bone loss associated with aging. Men (n = 253) aged 20-66 years were followed for 7.5 years and factors that influence changes in means and rates of change in bone mass, density, and size using dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) were investigated; in particular, seasons of sports participation during high school and college...
January 4, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29285628/diversity-of-activity-participation-determines-bone-mineral-content-in-the-lower-limbs-of-pre-pubertal-children-with-developmental-coordination-disorder
#8
S S M Fong, D Vackova, A W M Choi, Y T Y Cheng, T T T Yam, X Guo
This study examined the relationships between activity participation and bone mineralization in children with developmental coordination disorder. Limited participation in physical, recreational, social, and skill-based and self-improvement activities contributed to lower bone mineral content. For improved bone health, these children should participate in a variety of activities, not only physical activities. INTRODUCTION: Limited activity participation in children with developmental coordination disorder (DCD) may have a negative impact on bone mineral accrual...
December 28, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29282554/soccer-helps-build-strong-bones-during-growth-a-systematic-review-and-meta-analysis
#9
REVIEW
Gabriel Lozano-Berges, Ángel Matute-Llorente, Alejandro González-Agüero, Alejandro Gómez-Bruton, Alba Gómez-Cabello, Germán Vicente-Rodríguez, José A Casajús
The aim of this study was to analyze the effects of soccer practice on bone in male and female children and adolescents. MEDLINE, PubMed, SPORTDiscus and Web of Science databases were searched for scientific articles published up to and including October 2016. Twenty-seven studies were included in this systematic review (13 in the meta-analysis). The meta-analysis was performed by using OpenMeta[Analyst] software. It is well documented that soccer practice during childhood provides positive effects on bone mineral content (BMC) and density (BMD) compared to sedentary behaviors and other sports, such as tennis, weightlifting, or swimming...
December 28, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29251685/a-new-condition-in-mcardle-disease-poor-bone-health-benefits-of-an-active-lifestyle
#10
Irene Rodríguez-Gómez, Alfredo Santalla, Jorge Díez-Bermejo, Diego Munguía-Izquierdo, Luis M Alegre, Gisela Nogales-Gadea, Joaquin Arenas, Miguel Ángel Martín, Alejandro Lucía, Ignacio Ara
INTRODUCTION-PURPOSE: McArdle disease (muscle glycogen phosphorylase deficiency) is a genetic condition associated with exercise intolerance, but how it affects lean mass (LM) and bone mineral content (BMC) and density (BMD) in patients is unknown. We compared these variables between McArdle patients and age-/sex-matched healthy controls and assessed their potential association with physical activity levels in patients. METHODS: A case-control, cross-sectional design was used to examine LM, BMC, and BMD by using dual-energy x-ray absorptiometry in 136 young adults of both sexes (36 McArdle patients (33 ± 15 yr) and 103 controls (34 ± 11 yr))...
January 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29224068/hi-plex-for-simple-accurate-and-cost-effective-amplicon-based-targeted-dna-sequencing
#11
Bernard J Pope, Fleur Hammet, Tu Nguyen-Dumont, Daniel J Park
Hi-Plex is a suite of methods to enable simple, accurate, and cost-effective highly multiplex PCR-based targeted sequencing (Nguyen-Dumont et al., Biotechniques 58:33-36, 2015). At its core is the principle of using gene-specific primers (GSPs) to "seed" (or target) the reaction and universal primers to "drive" the majority of the reaction. In this manner, effects on amplification efficiencies across the target amplicons can, to a large extent, be restricted to early seeding cycles. Product sizes are defined within a relatively narrow range to enable high-specificity size selection, replication uniformity across target sites (including in the context of fragmented input DNA such as that derived from fixed tumor specimens (Nguyen-Dumont et al...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29218776/is-the-consumption-of-snail-meat-actually-healthy-an-analysis-of-the-osteotropic-influence-of-snail-meat-as-a-sole-source-of-protein-in-growing-rats
#12
R P Radzki, M Bieńko, P Polak, K Szkucik, M Ziomek, M Ostapiuk, J Bieniaś
The study was aimed at determining the osteotropic effects of diets containing snail meat as a sole protein source. In our experiment, we tested three different diets incorporating snail meat originating from Helix pomatia (HP), Cornu.aspesa maxima (CAM) and Cornu.aspersum aspersum (CAA) and compared these to a control diet (CON) in which casein was the source of protein. In all diets, the protein content amounted to 10%, as calculated on a dry weight basis. In the study, forty male Wistar rats with an initial body mass of 50 ± 2 g were randomly placed within the control and three experimental groups...
December 7, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29218051/sphingosine-1-phosphate-and-c-c-chemokine-receptor-2-dependent-activation-of-cd4-plasmacytoid-dendritic-cells-in-the-bone-marrow-contributes-to-signs-of-sepsis-induced-immunosuppression
#13
Anna Smirnov, Stephanie Pohlmann, Melanie Nehring, Shafaqat Ali, Ritu Mann-Nüttel, Stefanie Scheu, Anne-Charlotte Antoni, Wiebke Hansen, Manuela Büettner, Miriam J Gardiasch, Astrid M Westendorf, Florian Wirsdörfer, Eva Pastille, Marcel Dudda, Stefanie B Flohé
Sepsis is the dysregulated response of the host to systemic, mostly bacterial infection, and is associated with an enhanced susceptibility to life-threatening opportunistic infections. During polymicrobial sepsis, dendritic cells (DCs) secrete enhanced levels of interleukin (IL) 10 due to an altered differentiation in the bone marrow and contribute to the development of immunosuppression. We investigated the origin of the altered DC differentiation using murine cecal ligation and puncture (CLP), a model for human polymicrobial sepsis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29215830/-study-of-migration-and-distribution-of-bone-marrow-cells-transplanted-animals-with-b16-melanoma
#14
A F Poveshchenko, A O Solovieva, K E Zubareva, D N Strunkin, O B Gricyk, O V Poveshchenko, A V Shurlygina, V I Konenkov
Purpose. Reveal features migration and distribution of syngeneic bone marrow cells (BMC) and subpopulations (MSC) after transplantation into the recipient carrier B16 melanoma bodies. Methods. We used mouse male and female C57BL/6 mice. Induction of Tumor Growth: B16 melanoma cells implanted subcutaneously into right hind paw of female C57BL/6 mice at a dose of 2.5 x 105 cells / mouse. migration study in vivo distribution and BMC and MSC was performed using genetic markers - Y-chromosome specific sequence line male C57Bl/6 syngeneic intravenous transplantation in females using the polymerase chain reaction (PCR) in real time on Authorized Termal Cycler - Light Cycler 480 II / 96 (Roche)...
April 2017: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/29211791/body-size-and-hosts-of-triatoma-infestans-populations-affect-the-size-of-bloodmeal-contents-and-female-fecundity-in-rural-northwestern-argentina
#15
Ricardo E Gürtler, María Del Pilar Fernández, María Carla Cecere, Joel E Cohen
Human sleeping quarters (domiciles) and chicken coops are key source habitats of Triatoma infestans-the principal vector of the infection that causes Chagas disease-in rural communities in northern Argentina. Here we investigated the links among individual bug bloodmeal contents (BMC, mg), female fecundity, body length (L, mm), host blood sources and habitats. We tested whether L, habitat and host blood conferred relative fitness advantages using generalized linear mixed-effects models and a multimodel inference approach with model averaging...
December 6, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29208679/the-time-trial-effect-of-timing-of-stem-cell-delivery-following-st-elevation-myocardial-infarction-on-the-recovery-of-global-and-regional-left-ventricular-function-final-2-year-analysis
#16
Jay H Traverse, Timothy D Henry, Carl J Pepine, James T Willerson, Atul R Chugh, Phillip C Yang, David Zhao, Stephen G Ellis, John R Forder, Emerson C Perin, Marc S Penn, Antonis K Hatzopoulos, Jeffrey W Chambers, Kenneth Baran, Ganesh Raveendran, Adrian P Gee, Doris A Taylor, Lem Moyé, Ray F Ebert, Robert D Simari
Rationale: The TIME trial was the first cell therapy trial sufficiently powered to determine if timing of cell delivery following ST-elevation myocardial infarction (STEMI) affects recovery of left ventricular (LV) function. Objective: To report the 2-year clinical and cardiac magnetic resonance imaging (cMRI) results and their modification by microvascular obstruction (MVO). Methods and Results: TIME was a randomized, double-blind, placebo-controlled trial comparing 150 million bone marrow mononuclear cells (BMC) vs...
December 5, 2017: Circulation Research
https://www.readbyqxmd.com/read/29208404/naringin-prevents-bone-loss-in-a-rat-model-of-type-1-diabetes-mellitus
#17
M Rivoira, V Rodríguez, G Picotto, R Battaglino, N Tolosa de Talamoni
The aim of this work was to know whether naringin (NA) could prevent the bone complications in a model of streptozotocin (STZ) induced diabetes. Rats were divided in: 1) controls, 2) STZ-rats, 3) STZ-rats treated with 40 mg NA/kg, and 4) STZ-rats treated with 80 mg NA/kg. BMD and BMC were performed by DEXA. Bone histomorphometry and histology as well as TRAP staining were done in tibia. Osteocalcin (OCN) was determined in bone and serum. Glutathione content and SOD and catalase activities were assayed in bone marrow from femur...
December 2, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29207479/growth-and-bone-mineralization-of-very-preterm-infants-at-term-corrected-age-in-relation-to-different-nutritional-intakes-in-the-early-postnatal-period
#18
Michelle N Körnmann, Viola Christmann, Charlotte J W Gradussen, Laura Rodwell, Martin Gotthardt, Johannes B Van Goudoever, Arno F J Van Heijst
Preterm infants often have a reduced bone mineral content (BMC) with increased risk of metabolic bone disease. After birth it is difficult to supply calcium (Ca) and phosphorus (P) comparable to the high fetal accretion rate. It is not known whether high supplementation of minerals in the early postnatal period improves growth and bone mineralization. The aim of this study was to evaluate growth and bone mineralization at term corrected age (TCA) in very and extremely preterm infants who received different enteral Ca and P intakes during the first 10 days of life...
December 2, 2017: Nutrients
https://www.readbyqxmd.com/read/29202833/correction-to-diabetes-related-information-seeking-behaviour-a-systematic-review
#19
Silke Kuske, Tim Schiereck, Sandra Grobosch, Andrea Paduch, Sigrid Droste, Sarah Halbach, Andrea Icks
During the production process for this article [1] some errors were introduced into Table 2. The correct version of Table 2 can be found below; the original article [1] has also been updated with the correct version of Table 2. BMC apologises to the authors and to readers for this error.
December 4, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29192796/the-effect-of-weight-loss-on-body-composition-serum-bone-markers-and-adipokines-in-prepubertal-obese-children-after-1-year-intervention
#20
Joanna Gajewska, Jadwiga Ambroszkiewicz, Witold Klemarczyk, Magdalena Chełchowska, Halina Weker, Katarzyna Szamotulska
Purpose/Aim: The influence of weight loss on bone turnover and bone quality in childhood remains controversial, but it may implicate interactions between adiposity and bone metabolism. Therefore, we studied the relationships between bone markers and adipokines during weight loss in obese children. MATERIALS AND METHODS: We determined serum leptin, soluble leptin receptor, adiponectin, bone alkaline phosphatase (BALP), C-terminal telopeptide of type I collagen (CTX-I), osteocalcin (OC), carboxylated-OC (Gla-OC), undercarboxylated-OC (Glu-OC), sclerostin, body composition, and bone mineral density (BMD) in 40 obese prepubertal children before and after therapy...
December 1, 2017: Endocrine Research
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