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https://www.readbyqxmd.com/read/28893629/obesity-and-type-2-diabetes-not-a-diet-high-in-fat-sucrose-and-cholesterol-negatively-impacts-bone-outcomes-in-the-hyperphagic-otsuka-long-evans-tokushima-fatty-rat
#1
Laura C Ortinau, Melissa A Linden, Rebecca Dirkes, R Scott Rector, Pamela S Hinton
BACKGROUND: Obesity and type 2 diabetes (T2D) increase fracture risk; however, the association between obesity/T2D may be confounded by consumption of a diet high in fat, sucrose, and cholesterol (HFSC). OBJECTIVE: The study objective was to determine the main and interactive effects of obesity/T2D and a HFSC diet on bone outcomes using hyperphagic Otuska Long Evans Tokushima Fatty (OLETF) rats and normophagic Long Evans Tokushima Otsuka (LETO) controls. METHODS: At 8weeks of age, male OLETF and LETO rats were randomized to either a control (CON, 10 en% from fat as soybean oil) or HFSC (45 en% from fat as soybean oil/lard, 17 en% sucrose, and 1wt%) diet, resulting in four treatment groups...
September 9, 2017: Bone
https://www.readbyqxmd.com/read/28891353/development-of-an-inhalation-unit-risk-factor-for-ethylene-dibromide
#2
Heather R Schaefer, Jessica L Myers
The Texas Commission on Environmental Quality (TCEQ) follows standard scientific methods to develop up-to-date toxicity factors for chemicals emitted in the state of Texas. An inhalation unit risk factor (URF) was developed for ethylene dibromide (EDB, CAS 106-93-4) based on an increased incidence of nasal cavity adenocarcinomas observed in female rats in a 2-year inhalation cancer bioassay conducted by the National Toxicology Program (NTP). The NTP study provided evidence of several EDB-induced tumors in male and female rats and in female mice...
September 11, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28890923/publication-activity-in-medical-education-research-a-descriptive-analysis-of-submissions-to-the-gms-zeitschrift-f%C3%A3-r-medizinische-ausbildung-in-2007-2015
#3
Jan Matthes, Marianne Giesler, Michaela Wagner-Menghin, Monika Himmelbauer, Ingrid Preusche, Katrin Schüttpelz-Brauns
Objectives: The significance of medical education research has increased internationally. In this context we investigated whether, and if so, how the quantity and quality of scientific papers reviewed and/or published by the GMS Zeitschrift für Medizinische Ausbildung (GMS Z Med Ausbild) changed. Methods: The quantity and ratio of original papers, project reports and reviews submitted to or published in the GMS Z Med Ausbild were analysed. Published scientific articles were investigated in regard to the quality features "study type" and "mode of data collection" as well as the background (university affiliation) of the last authors...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28890905/single-versus-multiple-site-harvesting-techniques-for-bone-marrow-concentrate-evaluation-of-aspirate-quality-and-pain
#4
Kristin Oliver, Tariq Awan, Matthew Bayes
BACKGROUND: Bone marrow concentrate (BMC) is growing in popularity as an alternative treatment option in orthopaedics. The regenerative capacity of BMC has been linked to the number of mesenchymal stem cells (MSCs) present in the graft at the time of its clinical application. MSC counts in bone marrow aspirate (BMA) are affected by harvest technique, but controversy exists over which aspiration method optimizes cellular yield while taking patient comfort and risk into consideration. PURPOSE: To compare a single- versus multiple-site bone marrow aspiration technique to determine which would generate a sufficient volume of high-quality BMA for concentration into a BMC graft...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28890310/evaluating-the-american-college-of-surgeons-national-surgical-quality-improvement-project-risk-calculator-results-from-the-u-s-extrahepatic-biliary-malignancy-consortium
#5
Eliza W Beal, Ezra Lyon, Joe Kearney, Lai Wei, Cecilia G Ethun, Sylvester M Black, Mary Dillhoff, Ahmed Salem, Sharon M Weber, Thuy B Tran, George Poultsides, Rivfka Shenoy, Ioannis Hatzaras, Bradley Krasnick, Ryan C Fields, Stefan Buttner, Charles R Scoggins, Robert C G Martin, Chelsea A Isom, Kamron Idrees, Harveshp D Mogal, Perry Shen, Shishir K Maithel, Timothy M Pawlik, Carl R Schmidt
BACKGROUND: The objective of this study is to evaluate use of the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) online risk calculator for estimating common outcomes after operations for gallbladder cancer and extrahepatic cholangiocarcinoma. METHODS: Subjects from the United States Extrahepatic Biliary Malignancy Consortium (USE-BMC) who underwent operation between January 1, 2000 and December 31, 2014 at 10 academic medical centers were included in this study...
September 7, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28886923/the-effect-of-12-month-participation-in-osteogenic-and-non-osteogenic-sports-on-bone-development-in-adolescent-male-athletes-the-pro-bone-study
#6
Dimitris Vlachopoulos, Alan R Barker, Esther Ubago-Guisado, Francisco B Ortega, Peter Krustrup, Brad Metcalf, Jose Castro Pinero, Jonatan R Ruiz, Karen M Knapp, Craig A Williams, Luis A Moreno, Luis Gracia-Marco
OBJECTIVES: Research investigating the longitudinal effects of the most popular sports on bone development in adolescent males is scarce. The aim is to investigate the effect of 12-month participation in osteogenic and non-osteogenic sports on bone development. DESIGN: A 12-month study was conducted in adolescent males involved in football, swimming and cycling and compared with an active control group. METHODS: 116 adolescent males (13.1±0...
September 1, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28885590/ethnopharmacology-and-therapeutic-value-of-bridelia-micrantha-hochst-baill-in-tropical-africa-a-comprehensive-review
#7
REVIEW
Alfred Maroyi
Bridelia micrantha is traditionally used in tropical Africa to treat a wide range of human and animal diseases. The aim of this study was to summarise the research that has been done on the ethnomedicinal uses, phytochemistry and pharmacological properties of B. micrantha so as to understand its importance and potential value in primary healthcare systems. The literature search for information on ethnomedicinal uses and pharmacological activities of B. micrantha was undertaken using databases such as Web of Science, Scopus, Google Scholar, Science Direct, BioMed Central (BMC), PubMed and Springerlink...
September 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28885096/infant-hydrocephalus-in-sub-saharan-africa-the-reality-on-the-tanzanian-side-of-the-lake
#8
Maria M Santos, Derick K Rubagumya, Imani Dominic, Amos Brighton, Soledad Colombe, Philip O'Donnell, Micaella R Zubkov, Roger Härtl
OBJECTIVE Infant hydrocephalus is estimated to affect more than 100,000 new infants each year in sub-Saharan Africa (SSA). Bugando Medical Centre (BMC), a government-funded and patient cost-shared referral center, serves over 13 million people in the Lake and Western regions of Tanzania. The goals of this study were to characterize the infant population affected by hydrocephalus who presented to BMC and were treated with a ventriculoperitoneal shunt (VPS) to determine the rate of early complications associated with this surgical procedure and to assess its potential risk factors...
September 8, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28877645/bone-marrow-cavity-segmentation-using-graph-cuts-with-wavelet-based-texture-feature
#9
Hironori Shigeta, Tomohiro Mashita, Junichi Kikuta, Shigeto Seno, Haruo Takemura, Masaru Ishii, Hideo Matsuda
Emerging bioimaging technologies enable us to capture various dynamic cellular activities in vivo. As large amounts of data are obtained these days and it is becoming unrealistic to manually process massive number of images, automatic analysis methods are required. One of the issues for automatic image segmentation is that image-taking conditions are variable. Thus, commonly, many manual inputs are required according to each image. In this paper, we propose a bone marrow cavity (BMC) segmentation method for bone images as BMC is considered to be related to the mechanism of bone remodeling, osteoporosis, and so on...
August 25, 2017: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/28875297/breathing-motion-compensated-robotic-guided-stereotactic-body-radiation-therapy-patterns-of-failure-analysis
#10
Susanne Stera, Panagiotis Balermpas, Mark K H Chan, Stefan Huttenlocher, Stefan Wurster, Christian Keller, Detlef Imhoff, Dirk Rades, Jürgen Dunst, Claus Rödel, Guido Hildebrandt, Oliver Blanck
PURPOSE: We retrospectively evaluated the patterns of failure for robotic guided real-time breathing-motion-compensated (BMC) stereotactic body radiation therapy (SBRT) in the treatment of tumors in moving organs. PATIENTS AND METHODS: Between 2011 and 2016, a total of 198 patients with 280 lung, liver, and abdominal tumors were treated with BMC-SBRT. The median gross tumor volume (GTV) was 12.3 cc (0.1-372.0 cc). Medians of mean GTV BEDα/β =10  Gy (BED = biological effective dose) was 148...
September 5, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28872422/bone-turnover-markers-and-lean-mass-in-pubescent-boys-comparison-between-elite-soccer-players-and-controls
#11
Ammar Nebigh, Mohamed Elfethi Abed, Rihab Borji, Sonia Sahli, Slaheddine Sellami, Zouhair Tabka, Haithem Rebai
The aim of this study was to examine the relationship between bone mass and bone turnover markers with lean mass in pubescent soccer players. Two groups participated in this study 65 elite young soccer players that trained from 6 to 8 hours per week and 60 controls. Bone mineral density (BMD), bone mineral content (BMC) in the whole body, lower limbs, lumbar spine, and femoral neck, biochemical markers of osteocalcin (OC), bone-specific alkaline phosphatase (BAP), C-telopeptide type I collagen (CTX) and total lean mass were assessed...
September 5, 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28866895/attendance-of-older-patients-with-bone-metastases-at-a-multidisciplinary-bone-metastases-clinic-an-8-year-experience
#12
Leah Drost, Vithusha Ganesh, Bo Angela Wan, Albert Yee, Michael Ford, Joel Finkelstein, Elizabeth David, Selina Chow, Edward Chow, Leigha Rowbottom
BACKGROUND: Bone metastases clinic (BMC) is a multidisciplinary clinic where patients with bony metastases are assessed in conjunction by orthopedic surgery, radiation oncology, interventional radiology, and palliative medicine teams. The objective of the study was to determine the number of older adult (OA) referrals made to BMC and to examine their case dispositions. METHODS: Patients who were referred to the BMC from 2007 to 2015 were included in the study. Demographic information including gender, age, Karnofsky Performance Status (KPS), primary cancer site and reason for referral, as well as case dispositions were recorded for each patient...
July 11, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28866763/bone-health-is-maintained-while-fat-mass-is-reduced-in-pre-pubertal-children-with-obesity-participating-in-a-1-year-family-centered-lifestyle-intervention
#13
Tamara R Cohen, Tom J Hazell, Catherine A Vanstone, Celia Rodd, Hope A Weiler
Diet and physical activity (PA) influence bone health in children. This study tested whether increasing milk and milk products and weight-bearing types of PA favorably changed bone outcomes assessed by dual-energy X-ray absorptiometry (DXA) and bone biomarkers in children with obesity participating in a 1-year family-centered lifestyle intervention. Children were randomized to one of three groups: Control (Ctrl; no intervention), Standard treatment (StnTx: two servings milk and milk products/day; meet PA guidelines plus weight-bearing PA three times/week), or Modified treatment (ModTx: four servings milk and milk products/day; meet PA guidelines plus daily weight-bearing PA)...
September 2, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28865823/insufficient-evidence-supports-the-use-of-low-level-laser-therapy-to-accelerate-tooth-movement-prevent-orthodontic-relapse-and-modulate-acute-pain-during-orthodontic-treatment
#14
Adrian Farsaii, Thikriat Al-Jewair
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Efficacy of low-level laser therapy in accelerating tooth movement, preventing relapse and managing acute pain during orthodontic treatment in humans: A systematic review. Sonesson M, De Geer E, Subraian J, Petrén S. BMC Oral Health 2017;17:11. SOURCE OF FUNDING: No funding was obtained for this study TYPE OF STUDY/DESIGN: Systematic review.
September 2017: Journal of Evidence-based Dental Practice
https://www.readbyqxmd.com/read/28851830/experimental-and-statistical-reevaluation-provides-no-evidence-for-drosophila-courtship-song-rhythms
#15
David L Stern, Jan Clemens, Philip Coen, Adam J Calhoun, John B Hogenesch, Ben J Arthur, Mala Murthy
From 1980 to 1992, a series of influential papers reported on the discovery, genetics, and evolution of a periodic cycling of the interval between Drosophila male courtship song pulses. The molecular mechanisms underlying this periodicity were never described. To reinitiate investigation of this phenomenon, we previously performed automated segmentation of songs but failed to detect the proposed rhythm [Arthur BJ, et al. (2013) BMC Biol 11:11; Stern DL (2014) BMC Biol 12:38]. Kyriacou et al. [Kyriacou CP, et al...
August 29, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28841820/a-weighted-string-kernel-for-protein-fold-recognition
#16
Saghi Nojoomi, Patrice Koehl
BACKGROUND: Alignment-free methods for comparing protein sequences have proved to be viable alternatives to approaches that first rely on an alignment of the sequences to be compared. Much work however need to be done before those methods provide reliable fold recognition for proteins whose sequences share little similarity. We have recently proposed an alignment-free method based on the concept of string kernels, SeqKernel (Nojoomi and Koehl, BMC Bioinformatics, 2017, 18:137). In this previous study, we have shown that while Seqkernel performs better than standard alignment-based methods, its applications are potentially limited, because of biases due mostly to sequence length effects...
August 25, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28835898/chronic-effects-of-resistance-training-in-breast-cancer-survivors
#17
REVIEW
Wanderson Divino Nilo Dos Santos, Paulo Gentil, Rafael Felipe de Moraes, João Batista Ferreira Júnior, Mário Hebling Campos, Claudio Andre Barbosa de Lira, Ruffo Freitas Júnior, Martim Bottaro, Carlos Alexandre Vieira
Objective. To analyse effects of resistance training (RT) in breast cancer survivors (BCS) and how protocols and acute variables were manipulated. Methods. Search was made at PubMed, Science Direct, and LILACS. All articles published between 2000 and 2016 were considered. Studies that met the following criteria were included: written in English, Spanish, or Portuguese; BCS who have undergone surgery, chemotherapy, and/or radiotherapy; additional RT only; analysis of muscle performance, body mass composition (BMC), psychosocial parameters, or blood biomarkers...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28818662/organic-matter-quality-structures-benthic-fatty-acid-patterns-and-the-abundance-of-fungi-and-bacteria-in-temperate-lakes
#18
Robert Taube, Lars Ganzert, Hans-Peter Grossart, Gerd Gleixner, Katrin Premke
Benthic microbial communities (BMCs) play important roles in the carbon cycle of lakes, and benthic littoral zones in particular have been previously highlighted as biogeochemical hotspots. Dissolved organic matter (DOM) presents the major carbon pool in lakes, and although the effect of DOM composition on the pelagic microbial community composition is widely accepted, little is known about its effect on BMCs, particularly aquatic fungi. Therefore, we investigated the composition of benthic littoral microbial communities in twenty highly diverse lakes in northeast Germany...
August 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28818045/bmc-ecology-image-competition-2017-the-winning-images
#19
EDITORIAL
Christopher Foote, Chris T Darimont, Michel Baguette, Simon Blanchet, Luke M Jacobus, Dominique Mazzi, Josef Settele
For the fifth year, BMC Ecology is proud to present the winning images from our annual image competition. The 2017 edition received entries by talented shutterbug-ecologists from across the world, showcasing research that is increasing our understanding of ecosystems worldwide and the beauty and diversity of life on our planet. In this editorial we showcase the winning images, as chosen by our Editorial Board and guest judge Chris Darimont, as well as our selection of highly commended images. Enjoy!
August 18, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28817419/the-association-of-fat-and-lean-tissue-with-whole-body-and-spine-bone-mineral-density-is-modified-by-hiv-status-and-sex-in-children-and-youth
#20
Denise L Jacobson, Jane C Lindsey, Brent A Coull, Kathleen Mulligan, Priya Bhagwat, Grace M Aldrovandi
BACKGROUND: HIV-infected (HIV-pos) male children/youth showed lower bone mineral density at sexual maturity than HIV-uninfected (HIV-neg) females. It is not known whether complications of HIV disease, including abnormal body fat distribution, contribute to lower bone accrual in male HIV-pos adolescents. METHODS: In a cross-sectional study, we evaluated the relationship between body composition (fat and lean mass) and bone mass in HIV-pos and HIV-neg children/youth and determined if it is modified by HIV status and sex...
August 16, 2017: Pediatric Infectious Disease Journal
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