keyword
MENU ▼
Read by QxMD icon Read
search

Bmc

keyword
https://www.readbyqxmd.com/read/28431003/intracoronary-autologous-bone-marrow-cell-transfer-after-myocardial-infarction-the-boost-2-randomised-placebo-controlled-clinical-trial
#1
Kai C Wollert, Gerd P Meyer, Jochen Müller-Ehmsen, Carsten Tschöpe, Vernon Bonarjee, Alf Inge Larsen, Andreas E May, Klaus Empen, Emmanuel Chorianopoulos, Ulrich Tebbe, Johannes Waltenberger, Heiko Mahrholdt, Benedikta Ritter, Jens Pirr, Dieter Fischer, Mortimer Korf-Klingebiel, Lubomir Arseniev, Hans-Gert Heuft, Jan E Brinchmann, Diethelm Messinger, Bernd Hertenstein, Arnold Ganser, Hugo A Katus, Stephan B Felix, Meinrad P Gawaz, Kenneth Dickstein, Heinz-Peter Schultheiss, Dennis Ladage, Simon Greulich, Johann Bauersachs
Aims: Intracoronary infusion of autologous nucleated bone marrow cells (BMCs) enhanced the recovery of left ventricular ejection fraction (LVEF) after ST-segment elevation myocardial infarction (STEMI) in the randomised-controlled, open-label BOOST trial. We reassessed the therapeutic potential of nucleated BMCs in the randomised placebo-controlled, double-blind BOOST-2 trial conducted in 10 centres in Germany and Norway. Methods and results: Using a multiple arm design, we investigated the dose-response relationship and explored whether γ-irradiation which eliminates the clonogenic potential of stem and progenitor cells has an impact on BMC efficacy...
April 19, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28420294/smart-recognising-the-value-of-existing-practice-and-introducing-recent-developments-leaving-no-stone-unturned-in-the-assessment-and-treatment-of-the-pdoc-patient
#2
H Gill-Thwaites, K E Elliott, R Munday
Over the last 25 years there have been a number of papers highlighting the issues of high rates of misdiagnosis in prolonged disorders of consciousness (PDOC) (Andrews, K., Murphy, L., Munday, R., & Littlewood, C. (1996). Misdiagnosis of the vegetative state: Retrospective study in a rehabilitation unit. BMJ, 313(7048), 13-16; Childs, N. L., Mercer, W. N., & Childs, H. W. (1993). Accuracy of diagnosis of persistent vegetative state. Neurology, 43(8), 1465-1467). Surprisingly, these rates still remain at the same level despite defined criteria for diagnosis (Schnakers, C...
April 18, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28419547/perinatal-dna-methylation-at-cdkn2a-is-associated-with-offspring-bone-mass-findings-from-the-southampton-women-s-survey
#3
Elizabeth M Curtis, Robert Murray, Philip Titcombe, Eloïse Cook, Rebecca Clarke-Harris, Paula Costello, Emma Garratt, Joanna D Holbrook, Sheila Barton, Hazel Inskip, Keith M Godfrey, Christopher G Bell, Cyrus Cooper, Karen A Lillycrop, Nicholas C Harvey
Poor intrauterine and childhood growth has been linked with the risk of osteoporosis in later life, a relationship which may in part be mediated through altered epigenetic regulation of genes. We previously identified a region within the promoter of the long non-coding RNA ANRIL encoded by the CDKN2A locus, at which differential DNA methylation at birth showed correlations with offspring adiposity. Given the common lineage of adipocytes and osteoblasts, we investigated the relationship between perinatal CDKN2A methylation and bone mass at ages 4 and 6 years...
April 17, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28419380/%C3%AE-carboxysome-bioinformatics-identification-and-evolution-of-new-bacterial-microcompartment-protein-gene-classes-and-core-locus-constraints
#4
Manuel Sommer, Fei Cai, Matthew Melnicki, Cheryl A Kerfeld
Carboxysomes are bacterial microcompartments (BMCs) that enhance CO2 fixation in all cyanobacteria. Structurally, carboxysome shell proteins are classified according to the type of oligomer formed: hexameric (BMC-H), trimeric (BMC-T) and pentameric (BMC-P) proteins. To understand the forces driving the evolution of the carboxysome shell, we conducted a bioinformatic study of genes encoding β-carboxysome shell proteins, taking advantage of the recent large increase in sequenced cyanobacterial genomes. In addition to the four well-established BMC-H (CcmK1-4) classes, our analysis reveals two new CcmK classes, which we name CcmK5 and CcmK6...
April 17, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28409543/ccr-2-neutralization-augments-murine-fresh-bmc-activation-by-staphylococcus-aureus-via-two-distinct-mechanisms-at-the-level-of-ros-production-and-cytokine-response
#5
Ajeya Nandi, Biswadev Bishayi
CCR-2 signaling regulates recruitment of monocytes from the bone marrow into the bloodstream and then to sites of infection. We sought to determine whether CCL-2/CCR-2 signaling is involved in the killing of Staphylococcus aureus by murine bone marrow cells (BMCs). The intermittent link of reactive oxygen species (ROS)-NF-κB/p38-MAPK-mediated CCL-2 production in CCR-2 signaling prompted us to determine whether neutralization of CCR-2 augments the response of murine fresh BMCs (FBMCs) after S. aureus infection...
May 2017: Innate Immunity
https://www.readbyqxmd.com/read/28407038/emmaw-computing-minimal-absent-words-in-external-memory
#6
Alice Heliou, Solon P Pissis, Simon J Puglisi
Motivation: The biological significance of minimal absent words has been investigated in genomes of organisms from all domains of life. For instance, three minimal absent words of the human genome were found in Ebola virus genomes (Silva et al., Bioinf., 2015). There exists an O(n)-time and O(n)-space algorithm for computing all minimal absent words of a sequence of length n on a fixed-sized alphabet based on suffix arrays (Barton et al., BMC Bioinf., 2014). A standard implementation of this algorithm, when applied to a large sequence of length n, requires more than 20n bytes of RAM...
April 12, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28400678/key-role-of-stat4-deficiency-in-the-hematopoietic-compartment-in-insulin-resistance-and-adipose-tissue-inflammation
#7
Anca D Dobrian, Kaiwen Ma, Lindsey M Glenn, Margaret A Hatcher, Bronson A Haynes, Eric J Lehrer, Mark H Kaplan, Jerry L Nadler
Visceral adipose tissue (AT) inflammation is linked to the complications of obesity, including insulin resistance (IR) and type 2 diabetes. Recent data from our lab showed that germline deficiency in STAT4 reduces inflammation and improves IR in obese mice. The objective of this study was to determine the contribution of selective STAT4 deficiency in subsets of hematopoietic cells to IR and AT inflammation. To determine the contribution of hematopoietic lineage, we sublethally irradiated Stat4(-/-)C57Bl6 mice and reconstituted them with bone marrow cells (BMC) from Stat4(+/+)C57Bl6 congenic donors...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28396902/progressive-skeletal-benefits-of-physical-activity-when-young-as-assessed-at-the-midshaft-humerus-in-male-baseball-players
#8
S J Warden, A M Weatherholt, A S Gudeman, D C Mitchell, W R Thompson, R K Fuchs
Physical activity benefits the skeleton, but there is contrasting evidence regarding whether benefits differ at different stages of growth. The current study demonstrates that physical activity should be encouraged at the earliest age possible and be continued into early adulthood to gain most skeletal benefits. INTRODUCTION: The current study explored physical activity-induced bone adaptation at different stages of somatic maturity by comparing side-to-side differences in midshaft humerus properties between male throwing athletes and controls...
April 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28391397/changes-in-arm-tissue-composition-with-slowly-progressive-weight-lifting-among-women-with-breast-cancer-related-lymphedema
#9
Xiaochen Zhang, Justin C Brown, Electra D Paskett, Babette S Zemel, Andrea L Cheville, Kathryn H Schmitz
BACKGROUND: Studies in breast cancer-related lymphedema (BRCL) have exclusively examined total arm volume, but not the specific tissue composition that contributes to total volume. We evaluated baseline differences in arm tissue composition [fat mass, lean mass, bone mineral content (BMC), and bone mineral density (BMD)] between the affected and unaffected arms in women with BRCL. We compared changes in arm tissue composition and self-reported lymphedema symptoms after 1 year of weight-lifting versus control...
April 8, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28381233/structural-integrity-and-viability-of-fredericella-sultana-statoblasts-infected-with-tetracapsuloides-bryosalmonae-myxozoa-under-diverse-treatment-conditions
#10
Ahmed Abd-Elfattah, Mansour El-Matbouli, Gokhlesh Kumar
Fredericella sultana is an invertebrate host of Tetracapsuloides bryosalmonae, the causative agent of proliferative kidney disease in salmonids. The bryozoan produces seed-like statoblasts to facilitate its persistence during unfavourable conditions. Statoblasts from infected bryozoans can harbor T. bryosalmonae and give rise to infected bryozoan colonies when conditions improve. We aimed in the present study to evaluate the integrity and viability of T. bryosalmonae-infected statoblasts after a range of harsh treatment conditions...
April 5, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28374175/extensive-bmi-gain-in-puberty-is-associated-with-lower-increments-in-bone-mineral-density-in-estonian-boys-with-overweight-and-obesity-a-3-year-longitudinal-study
#11
Eva Mengel, Vallo Tillmann, Liina Remmel, Pille Kool, Priit Purge, Evelin Lätt, Jaak Jürimäe
The aim of this 3-year prospective study was to examine changes in bone mineral characteristics during pubertal maturation in boys with different BMI values at the beginning of puberty and with different BMI increments during puberty. 26 boys with overweight and obesity (OWB) and 29 normal weight boys (NWB) were studied yearly for 3 years from the age of 11 years to measure the changes in different bone mineral characteristics. The OWB group was further divided into two subgroups according to extensive or non-extensive BMI increment during 3-year period...
April 3, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28365851/the-functional-muscle-bone-unit-in-children-with-cerebral-palsy
#12
I Duran, F Schütz, S Hamacher, O Semler, C Stark, J Schulze, J Rittweger, E Schoenau
Our results suggest that the prevalence of bone health deficits in children with CP was overestimated, when using only age- and height-adjusted bone mineral content (BMC) and areal bone mineral density (aBMD). When applying the functional muscle-bone unit diagnostic algorithm (FMBU-A), the prevalence of positive results decreased significantly. We recommend applying the FMBU-A when assessing bone health in children with CP. INTRODUCTION: The prevalence of bone health deficits in children with cerebral palsy (CP) might be overestimated because age- and height-adjusted reference percentiles for bone mineral content (BMC) and areal bone mineral density (aBMD) assessed by dual-energy X-ray absorptiometry (DXA) do not consider reduced muscle activity...
April 1, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28365850/acute-bone-changes-after-lower-limb-amputation-resulting-from-traumatic-injury
#13
D A Bemben, V D Sherk, W J J Ertl, M G Bemben
Bone health is critical for lower limb amputees, affecting their ability to use a prosthesis and their risk of osteoporosis. We found large losses in hip bone mineral density (BMD) and in amputated bone strength in the first year of prosthesis use, suggesting a need for load bearing interventions early post-amputation. INTRODUCTION: Large deficits in hip areal BMD (aBMD) and residual limb volumetric BMD (vBMD) occur after lower limb amputation; however, the time course of these bone quality changes is unknown...
April 1, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28361713/the-joint-nettab-integrative-bioinformatics-2015-meeting-aims-topics-and-outcomes
#14
EDITORIAL
Paolo Romano, Ralf Hofestädt, Matthias Lange, Domenica D'Elia
The 15(th) International NETTAB workshop and the 11(th) Integrative Bioinformatics Symposium were held together in Bari, on October 14-16, 2016, as Joint NETTAB/IB 2015 Meeting. A special topic for the meeting was "Bioinformatics for ncRNA", but the traditional topics of both meetings series were also included in the event.About 60 scientific contributions were presented, including six keynote lectures, one special guest lecture, and many oral communications and posters. A "Two-Day Hands-on Tutorial" event was organised before the workshop...
March 23, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28359868/heterologous-expression-of-the-halothiobacillus-neapolitanus-carboxysomal-gene-cluster-in-corynebacterium-glutamicum
#15
Meike Baumgart, Isabel Huber, Iman Abdollahzadeh, Thomas Gensch, Julia Frunzke
Compartmentalization represents a ubiquitous principle used by living organisms to optimize metabolic flux and to avoid detrimental interactions within the cytoplasm. Proteinaceous bacterial microcompartments (BMCs) have therefore created strong interest for the encapsulation of heterologous pathways in microbial model organisms. However, attempts were so far mostly restricted to Escherichia coli. Here, we introduced the carboxysomal gene cluster of Halothiobacillus neapolitanus into the biotechnological platform species Corynebacterium glutamicum...
March 27, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28359065/evaluating-weight-status-and-sex-as-moderators-of-the-association-of-serum-leptin-with-bone-mineral-density-in-children-and-adolescents%C3%A2
#16
Sara A Armaiz-Flores, Nichole R Kelly, Ovidiu A Galescu, Andrew P Demidowich, Anne M Altschul, Sheila M Brady, Van S Hubbard, Courtney K Pickworth, Marian Tanofsky-Kraff, Lauren B Shomaker, James C Reynolds, Jack A Yanovski
BACKGROUND/AIMS: Animal studies suggest that leptin may adversely affect bone mineral density (BMD). Clinical studies have yielded conflicting results. We therefore investigated associations between leptin and bone parameters in children. METHODS: 830 healthy children (age = 11.4 ± 3.1 years; 75% female; BMI standard deviation score [BMIz] = 1.5 ± 1.1) had fasting serum leptin measured with ELISA and body composition by dual-energy X-ray absorptiometry. The main effects for leptin and BMIz plus leptin's interactions with sex and BMIz were examined using hierarchical linear regressions for appendicular, pelvis, and lumbar spine BMD as well as bone mineral content (BMC), and bone area (BA)...
March 30, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28358858/a-preclinical-evaluation-of-alternative-site-for-islet-allotransplantation
#17
Chengshi Wang, Xiaojiong Du, Sirong He, Yujia Yuan, Pengfei Han, Dan Wang, Younan Chen, Jingping Liu, Bole Tian, Guang Yang, Shounan Yi, Fabao Gao, Zhihui Zhong, Hongxia Li, Jingqiu Cheng, Yanrong Lu
The bone marrow cavity (BMC) has recently been identified as an alternative site to the liver for islet transplantation. This study aimed to compare the BMC with the liver as an islet allotransplantation site in diabetic monkeys. Diabetes was induced in Rhesus monkeys using streptozocin, and the monkeys were then divided into the following three groups: Group1 (islets transplanted in the liver with immunosuppressant), Group 2 (islets transplanted in the tibial BMC), and Group 3 (islets transplanted in the tibial BMC with immunosuppressant)...
2017: PloS One
https://www.readbyqxmd.com/read/28351842/minute-myocardial-injury-as-measured-by-high-sensitive-troponin-t-serum-levels-predicts-the-response-to-intracoronary-infusion-of-bone-marrow-derived-mononuclear-cells-in-patients-with-stable-chronic-post-infarction-heart-failure-insights-from-the-topcare-chd
#18
Brigitte Luu, David M Leistner, Eva Herrmann, Florian H Seeger, Joerg Honold, Stephan Fichtlscherer, Andreas M Zeiher, Birgit Assmus
Rationale: Cell-based therapies are a promising option in patients with chronic post-infarction heart failure (ICM). However, the responses following intracoronary infusion of autologous bone marrow-derived mononuclear cells (BMC) are heterogeneous, which may be related to impaired cell retention in patients with ICM. Ischemic injury is associated with upregulation of prototypical chemoattractant cytokines mediating retention and homing of circulating cells. The development of ultrasensitive tests to measure troponin-T serum levels (hs-TnT) revealed the presence of ongoing minute myocardial injury even in patients with stable ICM...
March 28, 2017: Circulation Research
https://www.readbyqxmd.com/read/28348457/validation-of-dual-energy-x-ray-absorptiometry-to-predict-body-composition-of-channel-catfish-ictalurus-punctatus
#19
Maria S Johnson, Randall J Watts, Hugh S Hammer, Tim R Nagy, Stephen A Watts
Dual-energy X-ray absorptiometry (DXA) provides a noninvasive way to determine lean tissue mass (LTM), fat mass (FM), bone mineral content (BMC), and bone mineral density (BMD) in humans and small mammals. Live channel catfish (n=74, 78g - 1200 g) were anesthetized and scanned in both a lateral position and a dorsa-ventral position. Six individual fish (300g - 600g) were scanned five times each to determine precision by the coefficient of variation. Precision was good for LTM (0.75-1.06%) and for BMC and BMD (2-2...
February 2017: Journal of the World Aquaculture Society
https://www.readbyqxmd.com/read/28338379/head-neck-trunk-and-pelvis-tissue-mass-predictions-for-young-adults-using-anthropometric-measures-and-dxa
#20
Danielle L Gyemi, Charles Kahelin, Nicole C George, David M Andrews
Accurate prediction of wobbling mass (WM), fat mass (FM), lean mass (LM) and bone mineral content (BMC) of living people using regression equations developed from anthropometric measures (lengths, circumferences, breadths, skinfolds) has previously been reported, but only for the extremities. Multiple linear stepwise regression was used to generate comparable equations for the head, neck, trunk and pelvis of young adults (38 males, 38 females). Equations were validated using actual tissue masses from an independent sample of 13 males and 13 females by manually segmenting full body Dual-energy X-ray Absorptiometry scans...
March 24, 2017: Journal of Applied Biomechanics
keyword
keyword
17929
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"