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https://www.readbyqxmd.com/read/28202954/in-vitro-characterization-and-concerted-function-of-three-core-enzymes-of-a-glycyl-radical-enzyme-associated-bacterial-microcompartment
#1
Jan Zarzycki, Markus Sutter, Niña Socorro Cortina, Tobias J Erb, Cheryl A Kerfeld
Many bacteria encode proteinaceous bacterial microcompartments (BMCs) that encapsulate sequential enzymatic reactions of diverse metabolic pathways. Well-characterized BMCs include carboxysomes for CO2-fixation, and propanediol- and ethanolamine-utilizing microcompartments that contain B12-dependent enzymes. Genes required to form BMCs are typically organized in gene clusters, which promoted their distribution across phyla by horizontal gene transfer. Recently, BMCs associated with glycyl radical enzymes (GREs) were discovered; these are widespread and comprise at least three functionally distinct types...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28201952/mortality-among-people-living-with-hiv-on-antiretroviral-treatment-in-bali-indonesia-incidence-and-predictors
#2
Sri Utami, Anak Agung Sagung Sawitri, Luh Putu Lila Wulandari, I Wayan Gede Artawan Eka Putra, Putu Ayu Swandewi Astuti, Dewa Nyoman Wirawan, Louise Causer, Bradley Mathers
Indonesia has the third highest number of people living with HIV/AIDS (PLWH) and the greatest increase in proportion of AIDS-related mortality in the Asia Pacific region between 2005 and 2013. Longitudinal mortality data among PLWH in Indonesia are limited. We conducted a retrospective cohort study from medical records of antiretroviral treatment (ART) recipients attending Badung General Hospital (BGH) and Bali Medica Clinic (BMC) between 2006 and 2014. We explored incidence of mortality by Kaplan-Meier analysis and identified predictors using a Cox proportional hazard model...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28197890/relationships-among-diet-physical-activity-and-dual-plane-dual-energy-x-ray-absorptiometry-bone-outcomes-in-pre-pubertalgirls
#3
Jie Ren, Lynn S Brann, Kay S Bruening, Tamara A Scerpella, Jodi N Dowthwaite
: In pre-pubertal girls, nutrient intakes and non-aquatic organized activity were evaluated as factors in vertebral body bone mass, structure, and strength. Activity, vitamin B12, and dietary fiber predicted bone outcomes most consistently. Exercise and vitamin B12 appear beneficial, whereas high fiber intake appears to be adverse for vertebral body development. PURPOSE: Childhood development sets the baseline for adult fracture risk. Most studies evaluate development using postero-anterior (PA) dual-energy X-ray absorptiometry (DXA) areal bone mineral density, bone mineral content, and bone mineral apparent density...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28194186/safety-and-effectiveness-of-bone-marrow-cell-concentrate-in-the-treatment-of-chronic-critical-limb-ischemia-utilizing-a-rapid-point-of-care-system
#4
Venkatesh Ponemone, Saniya Gupta, Dalip Sethi, Manish Suthar, Monika Sharma, Richard J Powell, Kenneth Lee Harris, Nungshi Jungla, Priyadarshini Arambam, Upendra Kaul, Ashok Seth, Suhail Bukhari
Critical limb ischemia (CLI) is the end stage of lower extremity peripheral vascular disease (PVD) in which severe obstruction of blood flow results in ischemic rest pain, ulcers and/or gangrene, and a significant risk of limb loss. This open-label, single-arm feasibility study evaluated the safety and therapeutic effectiveness of autologous bone marrow cell (aBMC) concentrate in revascularization of CLI patients utilizing a rapid point-of-care device. Seventeen (17) no-option CLI patients with ischemic rest pain were enrolled in the study...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28193243/bite-size-research-bmc-research-notes-goes-back-to-its-roots
#5
EDITORIAL
Dirk Krüger, Diana M Marshall
Since it first launched in 2008, BMC Research Notes has been a place where researchers can publish short notes and observations, research outputs which are useful for the community but which can end up hidden in the lab notebook or as a footnote in a dataset. In order to re-affirm the importance of publishing these kinds of outputs, the journal is renewing its focus on publishing note articles as well as other potentially dark data such as short null results. Publishing these articles is useful for many researchers, therefore we are also expanding the scope to all scientific and clinical disciplines including health sciences, life sciences, physical sciences, mathematics and all engineering disciplines...
February 14, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28187947/partial-restoration-of-cftr-function-in-cftr-null-mice-following-targeted-cell-replacement-therapy
#6
Pascal Duchesneau, Rickvinder Besla, Mathieu F Derouet, Li Guo, Golnaz Karoubi, Amanda Silberberg, Amy P Wong, Thomas K Waddell
Cystic fibrosis (CF) is a fatal recessive genetic disorder caused by a mutation in the gene encoding CF transmembrane conductance regulator (CFTR) protein. Alteration in CFTR leads to thick airway mucus and bacterial infection. Cell therapy has been proposed for CFTR restoration, but efficacy has been limited by low engraftment levels. In our previous studies, we have shown that using a pre-conditioning regimen in combination with optimization of cell number and time of delivery, we could obtain greater bone marrow cell (BMC) retention in the lung...
February 8, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28181695/later-age-at-onset-of-independent-walking-is-associated-with-lower-bone-strength-at-fracture-prone-sites-in-older-men
#7
Alex Ireland, Stella Muthuri, Joern Rittweger, Judith E Adams, Kate A Ward, Diana Kuh, Rachel Cooper
Later age at onset of independent walking is associated with lower leg bone strength in childhood and adolescence. However it is unknown whether these associations persist into older age, or whether they are evident at axial (central) or upper limb sites. Therefore we examined walking age obtained at 2y and bone outcomes obtained by dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) scans at 60-64y in a nationally-representative cohort study of British people, the MRC National Survey of Health and Development...
February 9, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28179628/the-impact-of-hand-foot-and-mouth-disease-control-policies-in-singapore-a-qualitative-analysis-of-public-perceptions
#8
Karen Siegel, Alex R Cook, Hanh La
Hand foot and mouth disease (HFMD) is a widespread pediatric disease in Asia. Most cases are relatively mild and caused by Coxsackie viruses, but in epidemics caused by Enterovirus 71, severe complications can occur. In response to the deaths of dozens of children in a 1997 outbreak (Podin in BMC Public Health 6:180,1 Abubakar in Virus Res 61(1):1-9,2 WHO in3), Singapore practices childcare centre surveillance, case-isolation, and short-term closure of centres. We conducted 44 in-depth interviews with teachers, principals, and parents at four childcare centres in Singapore to better understand experiences with current control policies...
February 8, 2017: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28174268/failure-to-reproduce-period-dependent-song-cycles-in-drosophila-is-due-to-poor-automated-pulse-detection-and-low-intensity-courtship
#9
Charalambos P Kyriacou, Edward W Green, Arianna Piffer, Harold B Dowse
Stern has criticized a body of work from several groups that have independently studied the so-called "Kyriacou and Hall" courtship song rhythms of male Drosophila melanogaster, claiming that these ultradian ∼60-s cycles in the interpulse interval (IPI) are statistical artifacts that are not modulated by mutations at the period (per) locus [Stern DL (2014) BMC Biol 12:38]. We have scrutinized Stern's raw data and observe that his automated song pulse-detection method identifies only ∼50% of the IPIs found by manual (visual and acoustic) monitoring...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28159946/lean-body-mass-in-urban-north-indian-adolescents-and-its-relation-with-bone-health
#10
Raman K Marwaha, M K Garg, Kuntal Bhadra, Namita Mahalle, Ambrish Mithal, Nikhil Tandon
OBJECTIVE: To prepare percentile charts of lean body mass (LBM) among Indian urban children and adolescents; and to evaluate gender differences in LBM, and its relation with pubertal status. DESIGN: Cross-sectional school-based survey. SETTING: School in city of Delhi, India. PARTICIPANTS: 1403 apparently healthy children and adolescents (826 boys) with mean (SD) age 13.2(2.7) years. OUTCOME MEASURES: Lean body mass assessed by dual energy absorptiometry in urban Indian adolescents according to age group and gender...
February 2, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28157487/comparison-of-body-composition-and-adipokine-levels-between-thin-and-normal-weight-prepubertal-children
#11
Jadwiga Ambroszkiewicz, Joanna Gajewska, Katarzyna Szamotulska, Grażyna Rowicka, Witold Klemarczyk, Magdalena Chełchowska
OBJECTIVE: Thinness can have substantial consequences for child development and health. Adipokines, including leptin and adiponectin, play a significant role in the regulation of important metabolic functions. The aim of this study was to investigate associations between body composition and serum leptin and adiponectin levels in thin and normal-weight children. METHODS: The authors examined 100 healthy prepubertal children, who were divided into two subgroups: thin (n=50) and normal-weight children (n=50)...
February 1, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28156659/novel-tool-utilized-as-a-trigger-for-advance-care-planning-in-hospitalized-oncology-patients
#12
Sandhya Rao, Diane Sarnacki, Alexandra Dobie, Karla Damus, Gretchen Gignac
: 22 Background: Study Purpose: reduce inpatient oncology readmissions; determine if there is a need to standardize trigger for Advance Care Planning in the inpatient oncology population. METHODS: Investigational Quality Improvement Study January-June 2014. Retrospective chart review of oncology readmissions on the BMC Hematology and Oncology service during a 6 month period, January-June 2013 (N = 68). Data abstracted included: demographics (age, race/ethnicity, primary language, education, marital status, ECOG); type and stage of cancer; type of consults (palliative, spiritual, social services, integrative, PT/OT, hospice, visiting nurse)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28155668/bioinformatics-and-systems-biology-research-update-from-the-15-th-international-conference-on-bioinformatics-incob2016
#13
Christian Schönbach, Chandra Verma, Peter J Bond, Shoba Ranganathan
The International Conference on Bioinformatics (InCoB) has been publishing peer-reviewed conference papers in BMC Bioinformatics since 2006. Of the 44 articles accepted for publication in supplement issues of BMC Bioinformatics, BMC Genomics, BMC Medical Genomics and BMC Systems Biology, 24 articles with a bioinformatics or systems biology focus are reviewed in this editorial. InCoB2017 is scheduled to be held in Shenzen, China, September 20-22, 2017.
December 22, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28155656/2016-update-on-apbionet-s-annual-international-conference-on-bioinformatics-incob
#14
EDITORIAL
Christian Schönbach, Chandra Verma, Lawrence Jin Kiat Wee, Peter John Bond, Shoba Ranganathan
InCoB became since its inception in 2002 one of the largest annual bioinformatics conferences in the Asia-Pacific region with attendance ranging between 150 and 250 delegates depending on the venue location. InCoB 2016 in Singapore was attended by almost 220 delegates. This year, sessions on structural bioinformatics, sequence and sequencing, and next-generation sequencing fielded the highest number of oral presentation. Forty-four out 96 oral presentations were associated with an accepted manuscript in supplemental issues of BMC Bioinformatics, BMC Genomics, BMC Medical Genomics or BMC Systems Biology...
December 22, 2016: BMC Genomics
https://www.readbyqxmd.com/read/28155130/rapid-isolation-of-murine-primary-hepatocytes-for-chromosomal-analysis
#15
Kentaro Ariyoshi, Yohei Fujishima, Tomisato Miura, Yi Shang, Shizuko Kakinuma, Shimada Yoshiya, Kosuke Kasai, Akifumi Nakata, Akira Tachibana, Mitsuaki A Yoshida
Primary hepatocyte culture is a crucial tool for investigations of liver function and for evaluating the toxic effects of drugs. In addition, chromosomal analysis of hepatocytes could also prove useful for understanding the mechanisms of hepatocarcinogenesis. However, cultivation of primary hepatocytes for chromosome analysis has been hampered by the specific equipment and skill required to perform the in situ perfusion step necessary for isolation of primary hepatocytes. In the present study, we aimed to establish a simple and efficient method of isolating hepatocytes suitable for chromosome analysis...
February 2, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28153040/bicpams-software-for-biological-data-analysis-with-pattern-based-biclustering
#16
Rui Henriques, Francisco L Ferreira, Sara C Madeira
BACKGROUND: Biclustering has been largely applied for the unsupervised analysis of biological data, being recognised today as a key technique to discover putative modules in both expression data (subsets of genes correlated in subsets of conditions) and network data (groups of coherently interconnected biological entities). However, given its computational complexity, only recent breakthroughs on pattern-based biclustering enabled efficient searches without the restrictions that state-of-the-art biclustering algorithms place on the structure and homogeneity of biclusters...
February 2, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28132908/administration-of-an-activin-receptor-iib-ligand-trap-protects-male-juvenile-rhesus-macaques-from-simian-immunodeficiency-virus-associated-bone-loss
#17
Wen Guo, Karol M Pencina, Karyn O'Connell, Monty Montano, Liming Peng, Susan Westmoreland, Julie Glowacki, Shalender Bhasin
: HIV-infected individuals are at an increased risk of osteoporosis despite effective viral suppression. Observations that myostatin null mice have increased bone mass led us to hypothesize that simian immunodeficiency virus (SIV)-associated bone loss may be attenuated by blocking myostatin/TGFβ signaling. In this proof-of-concept study, pair-housed juvenile male rhesus macaques were inoculated with SIVmac239. Four weeks later, animals were treated with vehicle or Fc-conjugated soluble activin receptor IIB (ActR2B·Fc, iv...
January 26, 2017: Bone
https://www.readbyqxmd.com/read/28130750/pegylated-interferon-%C3%AE-ribavirin-therapy-enhances-bone-mineral-density-in-children-with-chronic-genotype-4-hcv-infection
#18
Ahmed Megahed, Nanees Salem, Abeer Fathy, Tarik Barakat, Mona Abd El Latif Alsayed, Suzy Abd El Mabood, Khaled R Zalata, Ahmed F Abdalla
BACKGROUND: The impact of chronic hepatitis C (CHC) on bone mineral density (BMD) has been well studied in adults with a relative paucity of data in children, especially concerning effect of treatment with pegylated interferon (PEG-IFN) plus ribavirin (RV). In the current work, we assessed prospectively changes in BMD in children with CHC before, during, and after treatment. METHODS: Forty-six consecutive children with noncirrhotic genotype 4 CHC were subjected to dual-energy X-ray absorptiometry at baseline, 24 weeks, 48 weeks of therapy and 24 weeks after treatment...
January 27, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28127757/donor-bone-marrow-cells-are-essential-for-inkt-cell-mediated-foxp3-treg-cell-expansion-in-a-murine-model-of-transplantation-tolerance
#19
Satoshi Miyairi, Toshihito Hirai, Rumi Ishii, Masayoshi Okumi, Shinichi Nunoda, Kenji Yamazaki, Yasuyuki Ishii, Kazunari Tanabe
Mixed chimerism induction is the most reliable method for establishing transplantation tolerance. We previously described a novel treatment using a suboptimal dose of anti-CD40 ligand (anti-CD40L) and liposomal formulation of a ligand for invariant natural killer T cells administered to sub-lethally irradiated recipient mice after donor bone marrow cell (BMC) transfer. Recipient mice treated with this regimen showed expansion of a Foxp3-positive regulatory T(Treg) cell phenotype, and formation of mixed chimera...
January 26, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28127386/the-surgical-pathology-laboratory-in-mwanza-tanzania-a-survey-on-the-reproducibility-of-diagnoses-after-the-first-years-of-autonomous-activity
#20
R Tumino, P F Rambau, F Callea, L Leoncini, R Monaco, J Kahima, V Stracca Pansa, L Viberti, D Amadori, P Giovenali, K A Mteta
BACKGROUND: In 2000, an Italian non-governmental organisation (NGO) began a 9-year project to establish a surgical pathology laboratory at the Bugando Medical Centre (BMC) in Mwanza, Tanzania, a country with a low Human Development Index (HDI), and as of 2009, the laboratory was operating autonomously. The present survey aims to evaluate the reproducibility of histological and cytological diagnoses assigned in the laboratory's early years of autonomous activity. We selected a random sample of 196 histological and cytological diagnoses issued in 2010-2011 at the BMC surgical pathology laboratory...
2017: Infectious Agents and Cancer
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