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https://www.readbyqxmd.com/read/27871416/bone-marrow-aspirate-concentrate-for-bone-healing-in-foot-and-ankle-surgery
#1
REVIEW
Joshua S Harford, Travis J Dekker, Samuel B Adams
Autologous bone marrow aspirate concentrate (BMAC) has become a popular orthobiologic to augment bone healing. The potential benefit comes from osteoprogenitor cells and growth factors that can lead to new bone formation in the setting of foot and ankle arthrodesis procedures. BMAC has an excellent safety record and has demonstrated efficacy in animal models of bone healing. Although scant, the literature on the use of BMAC in foot and ankle surgery does demonstrate promise for this orthobiologic adjuvant.
December 2016: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/27864076/electric-field-as-a-potential-directional-cue-in-homing-of-bone-marrow-derived-mesenchymal-stem-cells-to-cutaneous-wounds
#2
Eliza Zimolag, Julia Borowczyk-Michalowska, Sylwia Kedracka-Krok, Bozena Skupien-Rabian, Elzbieta Karnas, Slawomir Lasota, Jolanta Sroka, Justyna Drukala, Zbigniew Madeja
Bone marrow-derived cells are thought to participate and enhance the healing process contributing to skin cells or releasing regulatory cytokines. Directional cell migration in a weak direct current electric field (DC-EF), known as electrotaxis, may be a way of cell recruitment to the wound site. Here we examined the influence of electric field on bone marrow adherent cells (BMACs) and its potential role as a factor attracting mesenchymal stem cells to cutaneous wounds. We observed that in an external EF, BMAC movement was accelerated and highly directed with distinction of two cell populations migrating toward opposite poles: mesenchymal stem cells migrated toward the cathode, whereas macrophages toward the anode...
November 15, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27813021/bone-marrow-aspirate-concentrate-for-the-treatment-of-osteochondral-lesions-of-the-talus-a-systematic-review-of-outcomes
#3
REVIEW
Jorge Chahla, Mark E Cinque, Jason M Shon, Daniel J Liechti, Lauren M Matheny, Robert F LaPrade, Thomas O Clanton
BACKGROUND: The goal of this perform a systematic review on the outcomes of bone marrow aspirate concentrate (BMAC) for the treatment of chondral defects and osteoarthritis (OA) of the talus. RESULTS: The systematic search performed identified 47 studies after duplicates were removed. After inclusion criteria were applied four studies were considered for insightful analysis for the treatment of focal chondral defects in the foot and ankle with the use of BMAC. Three studies were retrospective and one study was prospective in nature...
December 2016: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/27810548/immediate-transoral-allogeneic-bone-grafting-for-large-mandibular-defects-less-morbidity-more-bone-a-paradigm-in-benign-tumor-mandibular-reconstruction
#4
James C Melville, Nader N Nassari, Issa A Hanna, Jonathan W Shum, Mark E Wong, Simon Young
PURPOSE: Reconstruction of hard tissue continuity defects caused by ablative tumor surgery has been traditionally reconstructed with autogenous bone grafts or microvascular free flaps. Although results have been predictable from these 2 methods of reconstruction, the morbidity associated with bone harvest is quite serious for the patient. Predictable results have been obtained with using a combination of 100% cadaver bone, bone marrow aspirate concentrate (BMAC), and recombinant human bone morphogenic protein in immediate reconstruction for benign tumor extirpations through the extraoral approach...
October 6, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27768215/refixation-allograft-and-adjuvant-cell-therapy-to-treat-nonunion-of-the-femoral-neck-in-a-child
#5
Marina Magnani, Giovanni Trisolino, Stefano Stilli
INTRODUCTION: Idiopathic posttraumatic nonunion is a rare condition in children; the treatment of this complication is still controversial in this peculiar population. CASE REPORT: We report a case of a subcapital type II femoral neck fracture, in a 12-year-old boy, which was initially treated by internal fixation and subsequently went on to a nonunion at the femoral neck, in absence of infection or other disease.1 year after index surgery we performed surgical debridement and refixation with plate and bone allograft, added with autologous bone marrow aspiration concentrate (BMAC) and platelet-rich fibrin (PRF)...
October 15, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/27761221/the-basic-science-of-bone-marrow-aspirate-concentrate-in-chondral-injuries
#6
James Holton, Mohamed Imam, Jonathan Ward, Martyn Snow
There has been great interest in bone marrow aspirate concentrate (BMAC) as a cost effective method in delivering mesenchymal stem cells (MSCs) to aid in the repair and regeneration of cartilage defects. Alongside MSCs, BMAC contains a range of growth factors and cytokines to support cell growth following injury. However, there is paucity of information relating to the basic science underlying BMAC and its exact biological role in supporting the growth and regeneration of chondrocytes. The focus of this review is the basic science underlying BMAC in relation to chondral damage and regeneration...
September 19, 2016: Orthopedic Reviews
https://www.readbyqxmd.com/read/27566242/a-prospective-single-blind-placebo-controlled-trial-of-bone-marrow-aspirate-concentrate-for-knee-osteoarthritis
#7
Shane A Shapiro, Shari E Kazmerchak, Michael G Heckman, Abba C Zubair, Mary I O'Connor
BACKGROUND: Bone marrow aspirate concentrate (BMAC) is increasingly used as a regenerative therapy for musculoskeletal pathological conditions despite limited evidence-based support. HYPOTHESIS: BMAC will prove feasible, safe, and efficacious for the treatment of pain due to mild to moderate degenerative joint disease of the knee. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2. METHODS: In this prospective, single-blind, placebo-controlled trial, 25 patients with bilateral knee pain from bilateral osteoarthritis were randomized to receive BMAC into one knee and saline placebo into the other...
August 26, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27515308/identification-and-validation-of-multiple-cell-surface-markers-of-clinical-grade-adipose-derived-mesenchymal-stromal-cells-as-novel-release-criteria-for-good-manufacturing-practice-compliant-production
#8
Emily T Camilleri, Michael P Gustafson, Amel Dudakovic, Scott M Riester, Catalina Galeano Garces, Christopher R Paradise, Hideki Takai, Marcel Karperien, Simon Cool, Hee-Jeong Im Sampen, A Noelle Larson, Wenchun Qu, Jay Smith, Allan B Dietz, Andre J van Wijnen
BACKGROUND: Clinical translation of mesenchymal stromal cells (MSCs) necessitates basic characterization of the cell product since variability in biological source and processing of MSCs may impact therapeutic outcomes. Although expression of classical cell surface markers (e.g., CD90, CD73, CD105, and CD44) is used to define MSCs, identification of functionally relevant cell surface markers would provide more robust release criteria and options for quality control. In addition, cell surface expression may distinguish between MSCs from different sources, including bone marrow-derived MSCs and clinical-grade adipose-derived MSCs (AMSCs) grown in human platelet lysate (hPL)...
August 11, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27489409/autologous-bone-marrow-mesenchymal-cell-induced-chondrogenesis-mcic
#9
REVIEW
Sung Woo Huh, Asode Ananthram Shetty, Saif Ahmed, Dong Hwan Lee, Seok Jung Kim
Degenerative and traumatic articular cartilage defects are common, difficult to treat, and progressive lesions that cause significant morbidity in the general population. There have been multiple approaches to treat such lesions, including arthroscopic debridement, microfracture, multiple drilling, osteochondral transplantation and autologous chondrocyte implantation (ACI) that are currently being used in clinical practice. Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC) is a single-staged arthroscopic procedure...
July 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/27474386/one-stage-cartilage-repair-using-a-hyaluronic-acid-based-scaffold-with-activated-bone-marrow-derived-mesenchymal-stem-cells-compared-with-microfracture-five-year-follow-up
#10
Alberto Gobbi, Graeme P Whyte
BACKGROUND: Articular cartilage injury is frequently encountered, yet treatment options capable of providing durable cartilage repair are limited. PURPOSE: To investigate the medium-term clinical outcomes of cartilage repair using a 1-stage technique of a hyaluronic acid-based scaffold with activated bone marrow aspirate concentrate (HA-BMAC) and compare results with those of microfracture. A secondary aim of this study was to identify specific patient demographic factors and cartilage lesion characteristics that are associated with superior outcomes...
July 29, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27379780/tissue-bioengineering-in-the-treatment-of-osteochondritis-dissecans-of-the-talus-in-children-with-open-physis-preliminary-results
#11
Gherardo Pagliazzi, Matteo Baldassarri, Luca Perazzo, Francesca Vannini, Francesco Castagnini, Roberto Buda
BACKGROUND: Juvenile osteochondritis dissecans of the talus (JOCDT) is a focal idiopathic lesion primarily of the subchondral bone leading to subsequent cartilaginous damage. The majority of the papers dealing with JOCDT reported heterogeneous case studies of patients treated with different cartilage repair techniques. The purpose of this paper is to retrospectively review both clinical and radiologic results among 7 patients affected by JOCDT treated with arthroscopic bone marrow aspirate concentrate (BMAC) transplantation with the 1-step technique...
July 2, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27379241/bone-marrow-aspirate-in-the-treatment-of-chondral-injuries
#12
REVIEW
James Holton, Mohamed A Imam, Martin Snow
The ability of mesenchymal stem cells (MSCs) to transdifferentiate into a desired cell lineage has captured the imagination of scientists and clinicians alike. The limited ability for chondrocytes to regenerate in chondral injuries has raised the concept of using MSCs to help regenerate and repair damaged tissue. The expansion of cells in a laboratory setting to be delivered back to the patient is too costly for clinical use in the present tough economic climate. This process is slow with due to the complexity of trying to imitate the natural environment and biological stimulation of chondral cell replication and proliferation...
2016: Frontiers in Surgery
https://www.readbyqxmd.com/read/27093877/emotional-response-to-a-therapeutic-technique-the-social-broad-minded-affective-coping
#13
Natasha Holden, James Kelly, Mary Welford, Peter J Taylor
OBJECTIVES: It has been suggested that savouring positive memories can generate positive emotions. Increasing positive emotion can have a range of benefits including reducing attention to and experiences of threat. This study investigated individuals' emotional reactions to a guided mental imagery task focussing on positive social memory called the 'social Broad Minded Affective Coping (BMAC)' technique. The study examined possible predictors of individuals' responses to this intervention...
April 20, 2016: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/27041895/can-bone-marrow-aspirate-concentrate-change-the-mineralization-pattern-of-the-anterior-maxilla-treated-with-xenografts-a-preliminary-study
#14
André Antonio Pelegrine, Marcelo Lucchesi Teixeira, Marcelo Sperandio, Thiago Sousa Almada, Karl Erik Kahnberg, Paulo José Pasquali, Antonio Carlos Aloise
OBJECTIVE: To evaluate bony reconstruction of the atrophic anterior maxilla using particulate grafts with or without autologous bone marrow aspirate concentrate (BMAC). MATERIALS AND METHODS: Eight patients with atrophy of the anterior maxilla due to teeth loss were selected and split into groups according to the type of material used: Control Group (CG) (n = 4) - particulate xenograft only and Test Group (TG) (n = 4) - a combination of particulate xenograft and BMAC...
January 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/26873608/synthesis-and-characterization-of-in-situ-forming-anionic-hydrogel-as-vitreous-substitutes
#15
Jue Liang, Jessica J Struckhoff, Hongwei Du, Paul D Hamilton, Nathan Ravi
The natural vitreous is a biological hydrogel consisting primarily of a collagen and anionic hyaluronate. It is surgically removed in many ocular diseases and replaced with fluids, gases, or silicone oils. We have been interested in developing synthetic hydrogels as vitreous substitutes. In this study, we combined the stiffness and hydrophobicity of polymethacrylamide (PMAM) and the anionic nature of polymethacrylate (PMAA) to make copolymers that would mimic the natural vitreous. We used bis-methacryloyl cystamine (BMAC) to introduce thiol groups for reversible crosslink...
February 13, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/26798765/concentrated-bone-marrow-aspirate-for-the-treatment-of-chondral-injuries-and-osteoarthritis-of-the-knee-a-systematic-review-of-outcomes
#16
Jorge Chahla, Chase S Dean, Gilbert Moatshe, Cecilia Pascual-Garrido, Raphael Serra Cruz, Robert F LaPrade
BACKGROUND: Bone marrow aspirate concentrate (BMAC) has emerged as a novel treatment for pathology of the knee. Despite containing a limited number of stem cells, BMAC serves as a source of growth factors that are thought to play an important role as a result of their anabolic and anti-inflammatory effects. To our knowledge, there is no systematic review regarding the outcomes of bone marrow aspirate concentrate used for the treatment of chondral defects and osteoarthritis of the knee...
January 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/26781131/operative-treatment-of-fifth-metatarsal-jones-fractures-zones-ii-and-iii-in-the-nba
#17
Martin O'Malley, Bridget DeSandis, Answorth Allen, Matthew Levitsky, Quinn O'Malley, Riley Williams
BACKGROUND: Proximal fractures of the fifth metatarsal (zone II and III) are common in the elite athlete and can be difficult to treat because of a tendency toward delayed union, nonunion, or refracture. The purpose of this case series was to report our experience in treating 10 NBA players, determine the healing rate, return to play, refracture rate, and role of foot type in these athletes. METHODS: The records of 10 professional basketball players were retrospectively reviewed...
May 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/26574602/bone-marrow-concentrate-improves-early-cartilage-phase-maturation-of-a-scaffold-plug-in-the-knee-a-comparative-magnetic-resonance-imaging-analysis-to-platelet-rich-plasma-and-control
#18
COMPARATIVE STUDY
Aaron J Krych, Danyal H Nawabi, Nadja A Farshad-Amacker, Kristofer J Jones, Travis G Maak, Hollis G Potter, Riley J Williams
BACKGROUND: Limited information exists on the clinical use of a synthetic osteochondral scaffold plug for cartilage restoration in the knee. PURPOSE/HYPOTHESIS: The purpose of this study was to compare the early magnetic resonance imaging (MRI) appearance, including quantitative T2 values, between cartilage defects treated with a scaffold versus a scaffold with platelet-rich plasma (PRP) or bone marrow aspirate concentrate (BMAC). The hypothesis was that the addition of PRP or BMAC would result in an improved cartilage appearance...
January 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/26556393/electrically-elicited-muscle-torque-comparison-between-2500-hz-burst-modulated-alternating-current-and-monophasic-pulsed-current
#19
RANDOMIZED CONTROLLED TRIAL
Wayne Scott, Cheryl Adams, Shantelle Cyr, Brianna Hanscom, Kevin Hill, Jeffrey Lawson, Colin Ziegenbein
STUDY DESIGN: Single-blind, block-randomization crossover design. OBJECTIVE: To compare the knee extensor muscle torque production elicited with 2500-Hz burst-modulated alternating current (BMAC) and with a monophasic pulsed current (MPC) at the maximum tolerated stimulation intensity. BACKGROUND: Neuromuscular electrical stimulation (NMES) is often used for strengthening the quadriceps following knee surgery. Strength gains are dependent on muscle torque production, which is primarily limited by discomfort...
December 2015: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/26543482/maxillary-sinus-augmentation-combining-bio-oss-with-the-bone-marrow-aspirate-concentrate-a-histomorphometric-study-in-humans
#20
Paulo José Pasquali, Marcelo Lucchesi Teixeira, Thiago Altro de Oliveira, Luis Guilherme Scavone de Macedo, Antonio Carlos Aloise, André Antonio Pelegrine
Purpose. To investigate the regenerative results obtained with the association of bone marrow aspirate concentrate using the Bone Marrow Aspirate Concentrate (BMAC) method to a xenogeneic bone graft (Bio-Oss) in sinus floor elevation. Materials and Methods. Using a randomized controlled study design in eight consecutive patients (age of 55.4 ± 9.2 years), 16 sinus floor lift procedures were performed with Bio-Oss alone (control group, CG, n = 8) or combined with bone marrow aspirate concentrate obtained via the BMAC method (test group, TG, n = 8)...
2015: International Journal of Biomaterials
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