Huijun Yang, Shen Song, Jiacheng Li, Yandong Li, Jie Feng, Quan Sun, Xueting Qiu, Ziwei Chen, Xue Bai, Xinchang Liu, Hong Lian, Lihui Liu, Yongping Bai, Guogang Zhang, Yu Nie
Mammalian cardiomyocytes (CMs) undergo maturation during postnatal heart development to meet the increased demands of growth. Here, we found that omentin-1, an adipokine, facilitates CM cell cycle arrest and metabolic maturation. Deletion of omentin-1 causes mouse heart enlargement and dysfunction in adulthood and CM maturation retardation in juveniles, including delayed cell cycle arrest and reduced fatty acid oxidation. Through RNA sequencing, molecular docking analysis, and proximity ligation assays, we found that omentin-1 regulates CM maturation by interacting directly with bone morphogenetic protein 7 (BMP7)...
June 21, 2023: Cellular and Molecular Life Sciences: CMLS