Addison E Barnett, Ahmad Ozair, Anas S Bamashmos, Hong Li, David S Bosler, Gabrielle Yeaney, Assad Ali, David M Peereboom, Justin D Lathia, Manmeet S Ahluwalia
Introduction : Sex differences in glioblastoma (GBM) have been observed in incidence, genetic and epigenetic alterations, and immune response. These differences have extended to the methylation of the MGMT promoter, which critically impacts temozolomide resistance. However, the association between sex, MGMT methylation, and survival is poorly understood, which this study sought to evaluate. Methods : A retrospective cohort study was conducted and reported following STROBE guidelines, based on adults with newly diagnosed GBM who received their first surgical intervention at Cleveland Clinic (Ohio, USA) between 2012 and 2018...
March 31, 2024: Cancers