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JOURNAL ARTICLE
Qi Li, Dominique Lafrance, Moishe Liberman, Charles Leduc, Emmanuel Charbonney, Polina Titova, Hélène Manganas, Michaël Chassé
IMPORTANCE: Lung biopsies are sometimes performed in mechanically ventilated patients with acute hypoxemic respiratory failure (AHRF) of unknown etiology to guide patient management. While surgical lung biopsies (SLB) offer high diagnostic rates, they may also cause significant complications. Transbronchial forceps lung biopsies (TBLB) are less invasive but often produce non-contributive specimens. Transbronchial lung cryobiopsies (TBLC) yield specimens of potentially better quality than TBLB, but due to their novel implementation in the intensive care unit (ICU), their accuracy and safety are still unclear...
April 22, 2024: Journal of Intensive Care Medicine
#2
JOURNAL ARTICLE
Vladimir L Cousin, Tiphaine Corbisier, Peter C Rimensberger, Angelo Polito, Alice Bordessoule
Severe bronchiolitis patients are often supported with non-invasive ventilation (NIV). In case of NIV failure, we recently started to use non-invasive neurally adjusted ventilatory assist ventilation (NIV-NAVA) with a total face mask interface (TFM) and report now our experience with this modality of respiratory support. Retrospective study was made from October 2022 to May 2023 at the Geneva University Hospital Paediatric Intensive Care Unit. Inclusion criteria were children, aged from 0 to 6 months, with severe bronchiolitis with initial NIV failure and switch to NIV-NAVA-TFM...
April 6, 2024: European Journal of Pediatrics
#3
JOURNAL ARTICLE
R L McKinney, L Wallström, S E Courtney, R Sindelar
Patient-triggered modes of ventilation are currently the standard of practice in the care of term and preterm infants. Maintaining spontaneous breathing during mechanical ventilation promotes earlier weaning and possibly reduces ventilator-induced diaphragmatic dysfunction. A further development of assisted ventilation provides support in proportion to the respiratory effort and enables the patient to have full control of their ventilatory cycle. In this paper we will review the literature on two of these modes of ventilation: neurally adjusted ventilatory assist (NAVA) and proportional assist ventilation (PAV), propose future studies and suggest clinical applications of these modes...
March 26, 2024: Seminars in Perinatology
#4
JOURNAL ARTICLE
Anitha T, Gopu G, Arun Mozhi Devan P, Maher Assaad
Mechanical ventilation techniques are vital for preserving individuals with a serious condition lives in the prolonged hospitalization unit. Nevertheless, an imbalance amid the hospitalized people demands and the respiratory structure could cause to inconsistencies in the patient's inhalation. To tackle this problem, this study presents an Iterative Learning PID Controller (ILC-PID), a unique current cycle feedback type controller that helps in gaining the correct pressure and volume. The paper also offers a clear and complete examination of the primarily efficient neural approach for generating optimal inhalation strategies...
2024: PloS One
#5
JOURNAL ARTICLE
Damian Ratano, Binghao Zhang, Jose Dianti, Dimitrios Georgopoulos, Laurent J Brochard, Timothy C Y Chan, Ewan C Goligher
BACKGROUND: Lung- and diaphragm-protective (LDP) ventilation may prevent diaphragm atrophy and patient self-inflicted lung injury in acute respiratory failure, but feasibility is uncertain. The objectives of this study were to estimate the proportion of patients achieving LDP targets in different modes of ventilation, and to identify predictors of need for extracorporeal carbon dioxide removal (ECCO2 R) to achieve LDP targets. METHODS: An in silico clinical trial was conducted using a previously published mathematical model of patient-ventilator interaction in a simulated patient population (n = 5000) with clinically relevant physiological characteristics...
February 28, 2024: Intensive Care Medicine Experimental
#6
REVIEW
Michel Toussaint, Olivier van Hove, Dimitri Leduc, Lise Ansay, Nicolas Deconinck, Brigitte Fauroux, Sonia Khirani
BACKGROUND: Home mechanical ventilation (HMV) is the treatment for chronic hypercapnic alveolar hypoventilation. The proportion and evolution of paediatric invasive (IMV) and non-invasive (NIV) HMV across the world is unknown, as well as the disorders and age of children using HMV. METHODS: Search of Medline/PubMed for publications of paediatric surveys on HMV from 2000 to 2023. RESULTS: Data from 32 international reports, representing 8815 children (59% boys) using HMV, were analysed...
February 16, 2024: Thorax
#7
JOURNAL ARTICLE
Jona B Bernal, Joshua D R Downer, Vanessa H J Lin
No abstract text is available yet for this article.
January 23, 2024: Journal of Physiology
#8
JOURNAL ARTICLE
Grace Poole, Christopher Harris, Sandeep Shetty, Theodore Dassios, Allan Jenkinson, Anne Greenough
BACKGROUND: Neurally adjusted ventilatory assist (NAVA) is a mode of mechanical ventilation that delivers oxygen pressures in proportion to electrical signals of the diaphragm. The proportional assistance can be adjusted by the clinician to reduce the patient's work of breathing. Several case series of infants with congenital diaphragmatic hernias (CDH) have shown that NAVA may reduce oxygenation index and mean airway pressures. To date, no clinical trial has compared NAVA to standard methods of mechanical ventilation for babies with CDH...
January 20, 2024: Trials
#9
JOURNAL ARTICLE
Vaia Stamatopoulou, Evangelia Akoumianaki, Katerina Vaporidi, Efstathios Stamatopoulos, Eumorfia Kondili, Dimitrios Georgopoulos
BACKGROUND: During control mechanical ventilation (CMV), the driving pressure of the respiratory system (ΔPrs ) serves as a surrogate of transpulmonary driving pressure (ΔPlung ). Expiratory muscle activity that decreases end-expiratory lung volume may impair the validity of ΔPrs to reflect ΔPlung . This prospective observational study in patients with acute respiratory distress syndrome (ARDS) ventilated with proportional assist ventilation (PAV+), aimed to investigate: (1) the prevalence of elevated ΔPlung , (2) the ΔPrs -ΔPlung relationship, and (3) whether dynamic transpulmonary pressure (Plungsw ) and effort indices (transdiaphragmatic and respiratory muscle pressure swings) remain within safe limits...
January 12, 2024: Critical Care: the Official Journal of the Critical Care Forum
#10
JOURNAL ARTICLE
V Seenu Reddy, David M Stout, Robert Fletcher, Andrew Barksdale, Manesh Parikshak, Chanice Johns, Marc Gerdisch
OBJECTIVE: The study objective was to report early outcomes of integrating Hypotension Prediction Index-guided hemodynamic management within a cardiac enhanced recovery pathway on total initial ventilation hours and length of stay in the intensive care unit. METHODS: A multicenter, historical control, observational analysis of implementation of a hemodynamic management tool within enhanced recovery pathways was conducted by identifying cardiac surgery cases from 3 sites during 2 time periods, August 1 to December 31, 2019 (preprogram), and April 1 to August 31, 2021 (program)...
December 2023: JTCVS open
#11
JOURNAL ARTICLE
Daniel H Arellano, Roberto Brito, Caio C A Morais, Pablo Ruiz-Rudolph, Abraham I J Gajardo, Dannette V Guiñez, Marioli T Lazo, Ivan Ramirez, Verónica A Rojas, María A Cerda, Juan N Medel, Victor Illanes, Nivia R Estuardo, Alejandro R Bruhn, Laurent J Brochard, Marcelo B P Amato, Rodrigo A Cornejo
BACKGROUND: Internal redistribution of gas, referred to as pendelluft, is a new potential mechanism of effort-dependent lung injury. Neurally-adjusted ventilatory assist (NAVA) and proportional assist ventilation (PAV +) follow the patient's respiratory effort and improve synchrony compared with pressure support ventilation (PSV). Whether these modes could prevent the development of pendelluft compared with PSV is unknown. We aimed to compare pendelluft magnitude during PAV + and NAVA versus PSV in patients with resolving acute respiratory distress syndrome (ARDS)...
December 20, 2023: Annals of Intensive Care
#12
JOURNAL ARTICLE
Carlos Ferrando, Albert Carramiñana, Patricia Piñeiro, Lucia Mirabella, Savino Spadaro, Julián Librero, Fernando Ramasco, Gaetano Scaramuzzo, Oriol Cervantes, Ignacio Garutti, Ana Parera, Marta Argilaga, Gracia Herranz, Carmen Unzueta, Marc Vives, Kevin Regi, Marta Costa-Reverte, María Sonsoles Leal, Jesús Nieves-Alonso, Esther García, Aurelio Rodríguez-Pérez, Roberto Fariña, Sergio Cabrera, Elisabeth Guerra, Lucia Gallego-Ligorit, Alba Herrero-Izquierdo, J Vallés-Torres, Silvia Ramos, Daniel López-Herrera, Manuel De La Matta, Sertcakacilar Gokhan, Evrim Kucur, Ana Mugarra, Marina Soro, Laura García, José Alfonso Sastre, Pilar Aguirre, Claudia Jimena Salazar, María Carolina Ramos, Diego Rolando Morocho, Ramón Trespalacios, Félix Ezequiel-Fernández, Angella Lamanna, Leonarda Pia Cantatore, Donato Laforgia, Soledad Bellas, Carlos López, Ricard Navarro-Ripoll, Samira Martínez, Jordi Vallverdú, Adriana Jacas, María José Yepes-Temiño, Francisco Javier Belda, Gerardo Tusman, Fernando Suárez-Sipmann, Jesús Villar
BACKGROUND: It is uncertain whether individualisation of the perioperative open-lung approach (OLA) to ventilation reduces postoperative pulmonary complications in patients undergoing lung resection. We compared a perioperative individualised OLA (iOLA) ventilation strategy with standard lung-protective ventilation in patients undergoing thoracic surgery with one-lung ventilation. METHODS: This multicentre, randomised controlled trial enrolled patients scheduled for open or video-assisted thoracic surgery using one-lung ventilation in 25 participating hospitals in Spain, Italy, Turkey, Egypt, and Ecuador...
December 5, 2023: Lancet Respiratory Medicine
#13
JOURNAL ARTICLE
Lu Dai, Bixia Xie
Accurately prescribing supramaximal interval training facilitates targeting desired physiological adaptations. This study compared the homogeneity of adaptations in cardiorespiratory parameters to supramaximal [i.e., intensities beyond maximal aerobic speed (MAS)] interval interventions prescribed using anaerobic speed reserve (ASR), the speed attained at the end of 30-15 Intermittent Fitness Test (VIFT ), and MAS. Using repeated-measures factorial design, and during the off-season phase of the athletes' yearly training cycle, thirty national-level soccer players (age = 19 ± 1...
December 2023: Journal of Sports Science & Medicine
#14
JOURNAL ARTICLE
Karine Lacombe, Thomas Hueso, Raphael Porcher, Arsene Mekinian, Thibault Chiarabini, Sophie Georgin-Lavialle, Florence Ader, Julien Saison, Guillaume Martin-Blondel, Nathalie De Castro, Fabrice Bonnet, Charles Cazanave, Anne Francois, Pascal Morel, Olivier Hermine, Valerie Pourcher, Marc Michel, Xavier Lescure, Nora Soussi, Phillipe Brun, Fanny Pommeret, Pierre Sellier, Stella Rousset, Lionel Piroth, Jean-Marie Michot, Gabriel Baron, Xavier de Lamballerie, Xavier Mariette, Pierre-Louis Tharaux, Matthieu Resche-Rigon, Philippe Ravaud, Tabassome Simon, Pierre Tiberghien
OBJECTIVE: To evaluate the efficacy of covid-19 convalescent plasma to treat patients admitted to hospital for moderate covid-19 disease with or without underlying immunodeficiency (CORIPLASM trial). DESIGN: Open label, randomised clinical trial. SETTING: CORIMUNO-19 cohort (publicly supported platform of open label, randomised controlled trials of immune modulatory drugs in patients admitted to hospital with moderate or severe covid-19 disease) based on 19 university and general hospitals across France, from 16 April 2020 to 21 April 2021...
2023: BMJ Med
#15
JOURNAL ARTICLE
Alison Protain, Kimberly Firestone, Saima Hussain, Daniel Lubarsky, Howard Stein
BACKGROUND: Neonates with apnea of prematurity (AOP) clinically deteriorate because continuous positive airway pressure (CPAP) provides inadequate support during apnea. Neurally adjusted ventilatory assist (NAVA) provides proportional ventilator support from the electrical activity of the diaphragm. When the NAVA level is 0 cmH2 O/mcV (NAVA-PAP), patients receive CPAP when breathing and backup ventilation when apneic. This study evaluates NAVA-PAP and time spent in backup ventilation...
2023: Frontiers in Pediatrics
#16
JOURNAL ARTICLE
Y G Li, S L Chang, J F Xie, X Y Ye, L Wang, Y C Li, Y Li, X L Li
Objective: To investigate the clinical characteristics and risk factors of critical burn patients complicated with invasive fungal infection. Methods: A retrospective case series study was conducted. From January 2017 to December 2022, 88 critical burn patients combined with invasive fungal infection who met the inclusion criteria were admitted to Zhengzhou First People's Hospital, including 61 males and 27 females, aged 26-74 years. Data on invasive fungal infection sites and the detection of pathogens in patients were recorded...
July 20, 2023: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
#17
JOURNAL ARTICLE
Chendong Ma, Lihua Zhou, Fei Yang, Bin Li, Caixia Li, Aili Yu, Liankui Wu, Haibo Yin, Junyan Wang, Lixia Geng, Xiulian Wang, Jun Zhang, Na Zhuo, Kaiquan Wang, Yun Su, Fei Wang, Yujun Li, Lipeng Zhang
OBJECTIVE: To investigate the development present situation of the department of critical care medicine in Inner Mongolia Autonomous Region (hereinafter referred to as Inner Mongolia), in order to promote the standardized and homogeneous development of critical care medicine in Inner Mongolia, and also provide a reference for discipline construction and resource allocation. METHODS: A survey study was conducted in comprehensive intensive care unit (ICU) of tertiary and secondary hospitals in Inner Mongolia by online questionnaire survey and telephone data verification...
September 2023: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
#18
JOURNAL ARTICLE
Guanghui Zheng, Yijun Shi, Jialu Sun, Siqi Wang, Xiang Li, Hong Lv, Guojun Zhang
AIMS: To evaluate the effect of antibiotic prophylaxis(AP) in the prognosis of Post-neurosurgical meningitis(PNM) patients. METHODS: A cohort analysis was performed using the clinical database in Beijing Tiantan Hospital and Capital Medical University. Data were collected on patients with the diagnosis of PNM (n = 3931) during 2012.01 to 2022.04. The microbial distribution, types of AP, and 42 and 90 days survival analysis of AP patients were evaluated using probable statistical methods...
October 4, 2023: European Journal of Medical Research
#19
JOURNAL ARTICLE
Sarah A Angus, Joshua L Taylor, Leah M Mann, Alexandra M Williams, Eric J Stöhr, Jason S Au, Andrew William Sheel, Paolo B Dominelli
Intrathoracic pressure (ITP) swings that permit spontaneous ventilation have physiological implications for the heart. We sought to determine the effect of respiration on cardiac output ( <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"> <mml:semantics><mml:mover><mml:mi>Q</mml:mi> <mml:mo>̇</mml:mo></mml:mover> <mml:annotation>$\dot Q$</mml:annotation></mml:semantics> </mml:math> ) during semi-supine cycle exercise using a proportional assist ventilator to minimize ITP changes and lower the work of breathing (Wb )...
September 29, 2023: Journal of Physiology
#20
JOURNAL ARTICLE
Mengyu Wu, Xiaohong Zhang, Yu Jiang, Yun Guo, Wenjing Zhang, Hong He, Yanhua Yin
PURPOSE: To evaluate the effects of different mechanical ventilation modes on critical patients. METHODS: PubMed, Embase, Web of science, and Cochrane Library databases were searched from their inception to November 15, 2022 for randomized controlled trials on the application of different mechanical ventilation modes in critical patients. Two researchers independently screened the literature, extracted data, and assessed the risk of bias in the included studies...
2023: Frontiers in Medicine
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