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cancers of female GU tract

Ling Ma, Jinrong Qiu, Yaodong Zhang, Tianzhu Qiu, Biao Wang, Wensen Chen, Xiao Li, Jing Sun, Ke Wang, Xiangcheng Li, Yanhong Gu, Yongqian Shu, Xiaofeng Chen
Background: Biliary tract cancers (BTCs) are uncommon but fatal, with a low 5-year survival rate after surgical resection. This study was designed to investigate the prognostic factors for operable BTC. Methods: Baseline demographics at diagnosis were retrospectively evaluated in 341 BTC patients undergoing radical surgery at The First Affiliated Hospital of Nanjing Medical University from January 2011 to December 2015. The association between prognostic factors and overall survival (OS) was determined by multivariate analysis using the Cox proportional hazards regression model...
2018: OncoTargets and Therapy
Xin-En Huang, Xiao-Chun Yan, Lin Wang, Zhu-Qing Ji, Li Li, Meng-Yan Liu, Ting Qian, Hui-Ling Shen, Han-Gang Gu, Yong Liu, Ming Gu, Li-Chun Deng
OBJECTIVE: To assess the safety and effectiveness of thalidomide (produced by CHANGZHOU PHARMACEUTICAL FACTORY CO.LTD) combined with chemotherapy in treating patients with advanced colorectal cancer. METHOD: A consecutive cohort of pretreated patients with advanced colorectal cancer were treated with thalidomide combined with chemotherapy. And chemotherapy for patients with advanced colorectal cancer were administered according to the condition of patients. Thalidomide was orally administered at a dosage of 50mg/day to 150 mg/day before sleeping for at least 14 days...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Ali Mahdavinezhad, Seyed Habibollah Mousavi-Bahar, Jalal Poorolajal, Reza Yadegarazari, Mohammad Jafari, Nooshin Shabab, Massoud Saidijam
Bladder cancer (BC) ranks the second most common genitourinary tract malignant tumor with high mortality and 70% recurrence rate worldwide. MiRNAs expression has noticeable role in bladder tumorigenesis. The purpose of this study was to assess miR-200c, miR-30b and miR-141 in tissue samples of patients with BC and healthy adjacent tissue samples and their association with muscle invasion, grade and the size of the tumor. Transurethral resection tissue samples were collected from thirty- five newly diagnosed untreated patients with BC from 2013 to 2014...
2015: International Journal of Molecular and Cellular Medicine
Fu-jun Zhao, Philip S Li, Nian-qing Lü, Richard Lee, Yi-feng Peng, Feng Cheng, Zheng Li, Hao-qin Xu, Mark Barone, Marc Goldstein, Shu-jia Xia
Increasingly accumulated results from randomized controlled trials and other clinical studies have demonstrated that male circumcision reduces the risks of acquisition and transmission of HIV, HPV, HSV-2, and other sexually transmitted infections, and thus has a potential role in preventing cervical cancer, penile cancer and prostate cancer. The prevalence of male circumcision in China is currently less than 5%. The clinical evaluation studies and randomized controlled trials of the Shang Ring device showed excellent safety profiles, extremely high acceptability, and satisfaction among the participants and service providers in Africa and China...
November 2014: Zhonghua Nan Ke Xue, National Journal of Andrology
Yasmin M Abaza, Carlos Alemany
Primary urethral cancer is rare and accounts for only 0.003% of all malignancies arising from the female genitourinary tract. Due to the rarity of this disease, no consensus exists regarding the optimal therapeutic approach. Nanoparticle albumin-bound-paclitaxel has been shown to be effective in the treatment of a number of malignancies including metastatic breast, pancreatic, and bladder cancer. We present a 67-year-old woman with advanced metastatic urethral adenocarcinoma resistant to two lines of chemotherapy (ifosfamide/paclitaxel/cisplatin and irinotecan/5-fluorouracil/leucovorin) that showed a dramatic response to nanoparticle albumin-bound-paclitaxel...
2014: Case Reports in Urology
Katie H Stowers, Amber D Hartman, Jillian Gustin
BACKGROUND: Perineal pain is a frequent complaint of patients with advanced cancer (colorectal, genitourinary, prostate), and often quite difficult to manage with significant impact on quality of life. Calcium channel blockers (CCBs) are potent inhibitors of intestinal smooth muscle contraction and have been shown to impact tone and motility of the gastrointestinal tract. As such, they have been used in various pain syndromes of the lower gastrointestinal tract, such as chronic anal fissure, to promote healing and improve pain...
September 2014: Journal of Palliative Medicine
Jean-Baptiste Guy, Jane-Chloé Trone, François Casteillo, Fabien Forest, Cécile Pacaut, Coralie Moncharmont, Sophie Espenel, Alexis Vallard, Julien Langrand Escure, Olivier Collard, Michel Peoc'h, Nicolas Magné
Carcinosarcoma, also known as mixed mesodermal tumor or malignant mixed Mullerian tumor (MMMT) is a pathological entity combining a sarcomatous and a carcinomatous component. Found in thoracic, digestive, genitourinary, liver or skin locations, the most common location is the female genital tract. In gynecological tumors, carcinosarcoma accounts for about 2-5% of endometrial cancers, and 1% of ovarian cancers. To date, there is no consensus on the therapeutic strategy. It relies mostly on maximum cytoreductive surgery...
July 2014: Bulletin du Cancer
Christiane Kraft, Gundolf Schuettfort, Yvonne Weil, Vanessa Tirneci, Alexander Kasper, Barbara Haberichter, Jan Schwonberg, Marc Schindewolf, Edelgard Lindhoff-Last, Birgit Linnemann
BACKGROUND: Inferior vena cava thrombosis (IVCT) is a rare event, and studies detailing its underlying aetiologies are scarce. METHODS: One hundred and forty-one IVCT patients (57% females, median age 47 years) were analysed with a focus on malignancy-related thrombosis and compared with 141 age- and sex-matched control patients with isolated lower-extremity deep vein thrombosis. RESULTS: Malignancies were more prevalent among IVCT patients compared with the control group (39% vs...
September 2014: Thrombosis Research
Malihe Hasanzadeh, Hamid Reza Naderi, Azamossadat Hoseine Hoshyar, Shima Shabane, Soodabeh Shahidsales
BACKGROUND: Tuberculosis (TB) is still a major worldwide concern. There is no pathognomonic clinical feature or imaging findings for definite diagnosis of extra pulmonary TB. Therefore, TB involvement of Gastrointestinal or Genitourinary tract can be easily confused with peritoneal carcinomatosis and advanced ovarian carcinoma. Our aim is to emphasize the importance of considering the disease based upon the epidemiologic clues of the patients, while interpreting the positive results for a suspicious ovarian malignancy...
February 2014: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Zefiryn Cybulski, Iwona Urbaniak, Andrzej Roszak, Alicja Grabiec, Zofia Talaga, Piotr Klimczak
AIM: The main goal of this investigation was to evaluate the influence of positive Staphylococcus aureus culture from the genital tract on patients receiving radiation therapy, suffering from carcinoma of the uterus. The other aim was to observe radiation therapy complications. BACKGROUND: Radiation therapy of patients suffering from cervical cancer can be connected with inflammation of the genitourinary tract. MATERIALS AND METHODS: In years 2006-2010 vaginal swabs from 452 patients were examined...
2012: Reports of Practical Oncology and Radiotherapy
O N Alema, D O Martin, T R Okello
BACKGROUND: Upper gastrointestinal bleeding (UGIB) is a common emergency medical condition that may require hospitalization and resuscitation, and results in high patient morbidity. Upper gastrointestinal endoscopy is the preferred investigative procedure for UGIB because of its accuracy, low rate of complication, and its potential for therapeutic interventions. OBJECTIVE: To determine the endoscopic findings in patients presenting with UGIB and its frequency among these patients according to gender and age in Lacor hospital, northern Uganda...
December 2012: African Health Sciences
Yong Gao, Yisha He, Jing Xu, Lin Xu, Jiangbo Du, Chen Zhu, Haiyong Gu, Hongxia Ma, Zhibin Hu, Guangfu Jin, Xiaofei Chen, Hongbing Shen
A recently published genome-wide association study (GWAS) in European populations identified several loci at 4q21, 4q23 and 12q24 that were associated with risk of upper aerodigestive tract (UADT) cancers, including esophageal squamous cell carcinoma (ESCC). In the current study, we conducted a case-control study in a Chinese population including 2,139 ESCC cases and 2,273 controls to evaluate the associations of six reported single nucleotide polymorphisms (SNPs) (rs1494961, rs1229984, rs1789924, rs971074, rs671 and rs4767364) with risk of ESCC...
June 2013: Human Genetics
Michael D Harwich, Myrna G Serrano, Jennifer M Fettweis, João M P Alves, Mark A Reimers, Gregory A Buck, Kimberly K Jefferson
BACKGROUND: Bacteria of the genus Sneathia are emerging as potential pathogens of the female reproductive tract. Species of Sneathia, which were formerly grouped with Leptotrichia, can be part of the normal microbiota of the genitourinary tracts of men and women, but they are also associated with a variety of clinical conditions including bacterial vaginosis, preeclampsia, preterm labor, spontaneous abortion, post-partum bacteremia and other invasive infections. Sneathia species also exhibit a significant correlation with sexually transmitted diseases and cervical cancer...
2012: BMC Genomics
Mohammad Ahmadi, Hossein Ranjbaran, Marzeih Momeninejad Amiri, Jamshid Nozari, Mohammad Reza Mirzajani, Mohammad Azadbakht, Seyed Jalal Hosseinimehr
BACKGROUND: Bladder cancer is one the most common malignancies of the genitourinary tract. The present study aimed to assess the epidemiology, of bladder cancer in Mazandaran, a large province in northern Iran as high-incidence cancer area, during a 2-year period. METHODS: The data for this study were obtained from the population-based cancer registry of the Vice-Chancellory for Health Affairs of Mazandaran University of Medical Sciences and Mazandaran hospitals between March 1, 2010 and March 1, 2011...
2012: Asian Pacific Journal of Cancer Prevention: APJCP
Johannes Falke, Rianne J M Lammers, Harm C Arentsen, Miroslav Ravic, Raffaella Pozzi, Erik B Cornel, Henk Vergunst, Theo M de Reijke, J Alfred Witjes
PURPOSE: Imiquimod, a toll like receptor 7 (TLR-7) agonist, is effective as a topical treatment for skin malignancies. TMX-101 is a liquid formulation of imiquimod. In this study we establish a safety profile of TMX-101 in patients with nonmuscle invasive bladder cancer. MATERIALS AND METHODS: We conducted a multicenter phase 1 dose escalation study in patients with nonmuscle invasive bladder cancer. Patients were included in 1 of 4 dose groups (0.05%, 0.1%, 0.2% or 0...
June 2013: Journal of Urology
Ashok Srinivasan, Zhengming Gu, Teresa Smith, Markus Morgenstern, Anusha Sunkara, Guolian Kang, Deo K Srivastava, Aditya H Gaur, Wing Leung, Randall T Hayden
BACKGROUND: : The data on human rhinovirus, coronavirus, bocavirus, metapneumovirus, Chlamydophila pneumoniae, Mycoplasma pneumoniae and Bordetella pertussis infections in children with cancer is limited. METHODS: : We sought to determine prospectively the prevalence of respiratory pathogens in these children, using multiplexed-polymerase chain reaction. RESULTS: : We enrolled 253 children with upper or lower respiratory tract infection (LRTI) during a 1-year period...
March 2013: Pediatric Infectious Disease Journal
Lisa A Kachnic, Kathryn Winter, Robert J Myerson, Michael D Goodyear, John Willins, Jacqueline Esthappan, Michael G Haddock, Marvin Rotman, Parag J Parikh, Howard Safran, Christopher G Willett
PURPOSE: A multi-institutional phase 2 trial assessed the utility of dose-painted intensity modulated radiation therapy (DP-IMRT) in reducing grade 2+ combined acute gastrointestinal and genitourinary adverse events (AEs) of 5-fluorouracil (5FU) and mitomycin-C (MMC) chemoradiation for anal cancer by at least 15% compared with the conventional radiation/5FU/MMC arm from RTOG 9811. METHODS AND MATERIALS: T2-4N0-3M0 anal cancer patients received 5FU and MMC on days 1 and 29 of DP-IMRT, prescribed per stage: T2N0, 42 Gy elective nodal and 50...
May 1, 2013: International Journal of Radiation Oncology, Biology, Physics
Charles H Kirsch, Michael Goodman, Natia Esiashvili
OBJECTIVES: We analyzed outcomes of pediatric rhabdomyosarcoma (RMS) of the female genitourinary (GU) tract using the Surveillance Epidemiology and End Result database. MATERIALS AND METHODS: Females (0 to 19 years of age) diagnosed with RMS of GU sites between 1973 and 2006 were included in the analysis as 2 groups, 0 to 9 and 10 to 19-year-olds. They were compared for primary site distribution, stage, histology, and therapy. Kaplan-Meier method was used for survival analysis by histology, stage, and primary sites...
February 2014: American Journal of Clinical Oncology
Sheng Chen, Yu-Ling Cheng, Shi-Ting Li, Yao-Jun Ni, Biao Gu
OBJECTIVE: To investigate the effect of chemoradiotherapy after surgery on III A stage non-small cell lung cancer (NSCLC). METHODS: A total of 156 NSCLC patients undergoing total pneumonectomy or pulmonary lobectomy were included in this study. The chemotherapy group (n=75) received the protocol of cisplatin (DDP) + gemcitabine (GEM) / docetaxel (DOC) / vinorelbine (NVB); the radiotherapy + chemotherapy group (n=81) received sequential chemoradiotherapy. The response rate, local control rate in 1 to 2 years, overall survival (OS), progression-free survival (PFS) and adverse reactions were evaluated...
October 2012: Asian Pacific Journal of Tropical Medicine
Stefanos Bonovas, Georgios K Nikolopoulos, Pantelis G Bagos
BACKGROUND: Fibrates comprise a class of well-established antilipidemic agents that significantly reduce cardiovascular events. Given the concerns of cancer with fibrate therapy, we undertook a systematic review and meta-analysis to investigate the effects of fibrates on cancer outcomes. METHODS: We systematically searched Medline, Scopus, SCI Expanded, and the Cochrane Library for studies published up to 2012. We included randomized controlled trials (RCTs) that evaluated a fibrate therapy compared with placebo, had a minimum duration of two years, and reported data on the incidence of and/or deaths from cancer during the trial...
2012: PloS One
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