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https://www.readbyqxmd.com/read/29770290/current-surgical-strategies-and-techniques-of-aortic-valve-diseases-in-children
#1
REVIEW
Kun Wang, Huifeng Zhang, Bing Jia
While the long-term outcome of surgical aortic valvotomy (SAV) appears to be better than that of balloon aortic valvuloplasty (BAV) as the primary procedure of aortic valve stenosis, the surgical strategies and techniques of treating aortic valve disease in children in other situations remain controversial. Valve repair should be first considered while replacement is still unavoidable in some cases, and new repair techniques developed by innovative surgeons are gradually becoming adopted. Some complex repair procedures such as cusp extension, leaflet replacement/reconstruction have provided satisfactory outcomes...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29741481/urgent-balloon-aortic-valvuloplasty-in-patients-with-cardiogenic-shock-related-to-severe-aortic-stenosis-time-matters
#2
Nicolas Debry, Patrick Kone, Flavien Vincent, Gilles Lemesle, Cédric Delhaye, Guillaume Schurtz, Hugues Spillemaeker, Sina Porouchani, Augustin Coisne, Jean-Luc Auffray, Arnaud Sudre, Nicolas Lamblin, Laurent Bonello, Eric Van Belle
AIMS: To assess outcomes of balloon aortic valvuloplasty (BAV) as a rescue therapy in patients with cardiogenic shock (CS) related to severe aortic stenosis (AS). METHODS AND RESULTS: Forty-four consecutive patients, n=31 with hypotensive-CS (HCS) and n=13 with non-hypotensive CS (NHCS) due to acutely decompensated severe AS, from two centres were treated with emergency BAV. Composite primary endpoint was mortality or recurrent CS at 1-year follow-up. These patients (77...
May 8, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29736364/the-long-road-to-the-left-main-a-multidisciplinary-approach-to-the-revascularization-of-complex-left-main-coronary-artery-disease
#3
Scott Donald, Hilary Bews, Chantal Asselin, Basem Elbarouni, David Allen, Malek Kass, Siuchan Sookhoo, Davinder S Jassal
Severe aortic stenosis (AS) is considered a contraindication to the use of mechanical circulatory support (MCS) devices, including the Impella heart pump (Abiomed, Aachen, Germany). We describe a case in which a 72-year-old female with severe AS and peripheral vascular disease (PVD) presented with retractable ischemia in the setting of a non-ST elevation myocardial infarction (NSTEMI). Using a coordinated multidisciplinary approach, our case is the first to combine iliac angioplasty, balloon aortic valvuloplasty (BAV), and the insertion of an Impella CP device in the setting of severe AS to facilitate successful coronary artery revascularization in a non-surgical patient...
March 6, 2018: Curēus
https://www.readbyqxmd.com/read/29701363/david-operation-in-the-bicuspid-aortic-valve-population
#4
Pedro Magro, Marta Marques, Miguel Abecacis
INTRODUCTION: Bicuspid aortic valve (BAV) is the single most common cardiac congenital mal-formation with a prevalence of 1-2%. It is frequently associated with aortic disease including annular ectasia. Increasing evidence suggests that valve-sparing root re-implantation surgery combined with primary aortic valve repair can be performed with good midterm results in patients with BAV. METHODS: Our objective is to compare the short and long term results of David procedure in BAV patients with aortic root ectasia...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29695249/aortic-flow-patterns-and-wall-shear-stress-maps-by-4d-flow-cardiovascular-magnetic-resonance-in-the-assessment-of-aortic-dilatation-in-bicuspid-aortic-valve-disease
#5
José Fernando Rodríguez-Palomares, Lydia Dux-Santoy, Andrea Guala, Raquel Kale, Giuliana Maldonado, Gisela Teixidó-Turà, Laura Galian, Marina Huguet, Filipa Valente, Laura Gutiérrez, Teresa González-Alujas, Kevin M Johnson, Oliver Wieben, David García-Dorado, Arturo Evangelista
BACKGROUND: In patients with bicuspid valve (BAV), ascending aorta (AAo) dilatation may be caused by altered flow patterns and wall shear stress (WSS). These differences may explain different aortic dilatation morphotypes. Using 4D-flow cardiovascular magnetic resonance (CMR), we aimed to analyze differences in flow patterns and regional axial and circumferential WSS maps between BAV phenotypes and their correlation with ascending aorta dilatation morphotype. METHODS: One hundred and one BAV patients (aortic diameter ≤ 45 mm, no severe valvular disease) and 20 healthy subjects were studied by 4D-flow CMR...
April 26, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29684119/aortic-stiffness-in-adolescent-turner-and-marfan-syndrome-patients
#6
Michal Schäfer, Lorna P Browne, Uyen Truong, James J Jaggers, Max B Mitchell, Ladonna Malone, Gareth Morgan, Kathryn Chatfield, Daniel McLennan, Harma Turbendian, Danial Vargas, Brian Fonseca, Michael DiMaria, Anar Shah, Margaret P Ivy, Alex J Barker, Kendall S Hunter, Neil Wilson, D Dunbar Ivy, David N Campbell
OBJECTIVES: Turner syndrome (TS) and Marfan syndrome (MFS) are partially characterized by aortopathies with a risk of developing severe aortic dilation, stiffness and consequent dissection and aneurysm formation. The incidence of a bicuspid aortic valve (BAV) is also increased in TS. We investigated aortic stiffness in teenage TS and MFS patients and evaluated to what degree stiffness in TS patients is augmented by the presence of a BAV. METHODS: Fifty-seven patients with TS (n = 37) and MFS (n = 20), as well as 22 controls with similar age and size distribution underwent evaluation of thoracic aortic stiffness using phase-contrast magnetic resonance imaging...
April 19, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29671812/enlightening-the-association-between-bicuspid-aortic-valve-and-aortopathy
#7
REVIEW
Froso Sophocleous, Elena Giulia Milano, Giulia Pontecorboli, Pierpaolo Chivasso, Massimo Caputo, Cha Rajakaruna, Chiara Bucciarelli-Ducci, Costanza Emanueli, Giovanni Biglino
Bicuspid aortic valve (BAV) patients have an increased incidence of developing aortic dilation. Despite its importance, the pathogenesis of aortopathy in BAV is still largely undetermined. Nowadays, intense focus falls both on BAV morphology and progression of valvular dysfunction and on the development of aortic dilation. However, less is known about the relationship between aortic valve morphology and aortic dilation. A better understanding of the molecular pathways involved in the homeostasis of the aortic wall, including the extracellular matrix, the plasticity of the vascular smooth cells, TGFβ signaling, and epigenetic dysregulation, is key to enlighten the mechanisms underpinning BAV-aortopathy development and progression...
April 19, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29656818/the-aortic-root-does-not-dilate-over-time-after-replacement-of-the-aortic-valve-and-ascending-aorta-in-patients-with-bicuspid-or-tricuspid-aortic-valves
#8
Sonya K Hui, Chun-Po Steve Fan, Shakira Christie, Christopher M Feindel, Tirone E David, Maral Ouzounian
OBJECTIVE: Whether the aortopathy associated with bicuspid aortic valve (BAV) disease occurs secondary to genetic or hemodynamic factors remains controversial. In this article we describe the natural history of the aortic root in patients with bicuspid versus tricuspid aortic valves (TAVs) after replacement of the aortic valve and ascending aorta. METHODS: From 1990 to 2010, 406 patients (269 BAV, 137 TAV) underwent aortic valve and ascending aorta replacement at a single institution...
March 13, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29653232/gata6-loss-of-function-mutation-contributes-to-congenital-bicuspid-aortic-valve
#9
Ying-Jia Xu, Ruo-Min Di, Qi Qiao, Xiu-Mei Li, Ri-Tai Huang, Song Xue, Xing-Yuan Liu, Juan Wang, Yi-Qing Yang
Congenital bicuspid aortic valve (BAV), the most common form of birth defect in humans, is associated with substantial morbidity and mortality. Increasing evidence demonstrates that genetic risk factors play a key role in the pathogenesis of BAV. However, BAV is a genetically heterogeneous disease and the genetic determinants underpinning BAV in an overwhelming majority of patients remain unknown. In the present study, the coding exons and flanking introns of the GATA6 gene, which encodes a zinc-finger transcription factor essential for the normal development of the aortic valves, were sequenced in 152 unrelated patients with congenital BAV...
April 10, 2018: Gene
https://www.readbyqxmd.com/read/29625867/balloon-aortic-valvuloplasty-for-congenital-aortic-stenosis-a-14-year-single-centre-review
#10
Benjamin Auld, Lindsay Carrigan, Cameron Ward, Robert Justo, Nelson Alphonso, Ben Anderson
BACKGROUND: The approach to intervention for congenital aortic valve stenosis (AS) differs depending upon centre bias toward a primary catheter or surgical approach. We therefore investigated associations with freedom from re-intervention (FFI) in the cohort of children who underwent primary balloon aortic valvuloplasty (BAV) for congenital AS in our centre. METHODS: All patients who underwent BAV as a primary procedure in the period between 2001 and 2015 in a single service were included...
March 1, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29579303/impact-of-the-bicuspid-aortic-valve-on-aortic-root-haemodynamics-three-dimensional-computed-fluid-dynamics-simulation
#11
Denis Berdajs, Selim Mosbahi, Friedrich S Eckstein, Dominique Charbonnier, Enrico Ferrari, Ludwig K von Segesser
OBJECTIVES: The aim was to evaluate the impact of a bicuspid aortic valve (BAV) on local shear stress and on the pressure profile on the elements of the aortic root (AoR). METHODS: The experiment setup included a BAV with aortic valve stenosis (n = 5 pigs, 67 ± 3.5 kg) and insufficiency (n = 5 pigs, 66.7 ± 4.4 kg). By implanting 6 high-fidelity microsonometric crystals in each AoR, we determined the 3-dimensional (3D) geometry of the AoR. Experimental and geometric data were used to create a 3D time- and pressure-dependent computed fluid dynamic model of the AoR with the BAV...
March 22, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29572685/-statement-and-recommendation-of-the-professional-association-of-german-ophthalmologists-bva-the-german-ophthalmological-society-dog-and-the-german-retina-society-rg-on-central-serous-chorioretinopathy-situation-january-2018
#12
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
March 23, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29571667/impella-support-following-emergency-percutaneous-balloon-aortic-valvuloplasty-in-patients-with-severe-aortic-valve-stenosis-and-cardiogenic-shock
#13
Konstantinos Karatolios, Georgios Chatzis, Ulrich Luesebrink, Birgit Markus, Holger Ahrens, Dimitris Tousoulis, Bernhard Schieffer
BACKGROUND: To investigate the feasibility and outcomes of Impella 2.5 support in patients with severe aortic valve stenosis (AS) and cardiogenic shock (CS) who underwent emergency percutaneous balloon aortic valvuloplasty (BAV) with or without percutaneous coronary intervention (PCI). METHODS AND RESULTS: We retrospectively analyzed a consecutive series of patients with severe AS and CS who underwent Impella 2.5 support following emergency BAV with or without subsequent PCI...
March 20, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29567669/gata6-regulates-aortic-valve-remodeling-and-its-haploinsufficiency-leads-to-rl-type-bicuspid-aortic-valve
#14
Lara Gharibeh, Hiba Komati, Yohan Bossé, Munir Boodhwani, Mahyar Heydarpour, Megan Fortier, Romina Hassandazeh, Janet Ngu, Patrick Mathieu, Simon Body, Mona Nemer
Background -Bicuspid aortic valve (BAV), the most common congenital heart defect affecting 1-2% of the population, is a major risk factor for premature aortic valve disease and accounts for the majority of valve replacement. The genetic basis and the mechanisms of BAV etiology and pathogenesis remain largely undefined. Methods -Cardiac structure and function was assessed in mice lacking a Gata6 allele. Human GATA6 gene variants were analyzed in 452 BAV cases from the BAV consortium and 1849 controls from the Framingham GWAS study...
March 22, 2018: Circulation
https://www.readbyqxmd.com/read/29566797/variations-in-practice-patterns-and-consistency-with-published-guidelines-for-balloon-aortic-and-pulmonary-valvuloplasty-an-analysis-of-data-from-the-impact-registry
#15
Andrew C Glatz, Kevin F Kennedy, Jonathan J Rome, Michael L O'Byrne
OBJECTIVES: The authors sought to study variation in the practice of balloon aortic (BAV) and pulmonary valvuloplasty (BPV). BACKGROUND: The IMPACT (IMProving Adult and Congenital Treatment) registry provides an opportunity to study practice variation in transcatheter interventions for congenital heart disease. METHODS: The authors studied BAV and BPV in the IMPACT registry from January 1, 2011, to September 30, 2015, using hierarchical multivariable models to measure hospital-level variation in: 1) the distribution of indications for intervention; and 2) in cases with "high resting gradient" as the indication, consistency with published guidelines...
March 26, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29561783/bicuspid-aortic-valve-stenosis-and-the-effect-of-vitamin-k2-on-calcification-using-18-f-sodium-fluoride-positron-emission-tomography-magnetic-resonance-the-basik2-rationale-and-trial-design
#16
Frederique E C M Peeters, Manouk J W van Mourik, Steven J R Meex, Jan Bucerius, Simon M Schalla, Suzanne C Gerretsen, Casper Mihl, Marc R Dweck, Leon J Schurgers, Joachim E Wildberger, Harry J G M Crijns, Bas L J H Kietselaer
BASIK2 is a prospective, double-blind, randomized placebo-controlled trial investigating the effect of vitamin K2 (menaquinone-7;MK7) on imaging measurements of calcification in the bicuspid aortic valve (BAV) and calcific aortic valve stenosis (CAVS). BAV is associated with early development of CAVS. Pathophysiologic mechanisms are incompletely defined, and the only treatment available is valve replacement upon progression to severe symptomatic stenosis. Matrix Gla protein (MGP) inactivity is suggested to be involved in progression...
March 21, 2018: Nutrients
https://www.readbyqxmd.com/read/29552617/aortic-valve-anatomy-and-outcomes-after-transcatheter-aortic-valve-implantation-in-bicuspid-aortic-valves
#17
Chiara De Biase, Antonios Mastrokostopoulos, Raphael Philippart, Louis Marie Desroche, Stephanie Blanco, Kamel Rehal, Nicolas Dumonteil, Didier Tchetche
This original clinical research study id focused on description of baseline anatomy and outcomes after transcatheter aortic valve implantation (TAVI) in patients presenting with severe aortic stenosis (AS) and bicuspid aortic valve (BAV). We compared this BAV population with a population of patients with AS and tricuspid aortic valves after a propensity score matching developed by a multivariate logistic regression according to a non-parsimonious approach. Baseline anatomical characteristics were obtained by transthoracic echocardiography (TTE) and multi-sliced computed tomography (MSCT) and compared by chi-square and t-student tests...
April 2018: Data in Brief
https://www.readbyqxmd.com/read/29544877/structural-modeling-reveals-microstructure-strength-relationship-for-human-ascending-thoracic-aorta
#18
James R Thunes, Julie A Phillippi, Thomas G Gleason, David A Vorp, Spandan Maiti
High lethality of aortic dissection necessitates accurate predictive metrics for dissection risk assessment. The not infrequent incidence of dissection at aortic diameters <5.5 cm, the current threshold guideline for surgical intervention (Nishimura et al., 2014), indicates an unmet need for improved evidence-based risk stratification metrics. Meeting this need requires a fundamental understanding of the structural mechanisms responsible for dissection evolution within the vessel wall. We present a structural model of the repeating lamellar structure of the aortic media comprised of elastic lamellae and collagen fiber networks, the primary load-bearing components of the vessel wall...
February 8, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29541607/the-role-of-echocardiography-in-transcatheter-aortic-valve-implantation
#19
REVIEW
Toshinari Onishi, Kaoruko Sengoku, Yasuhiro Ichibori, Isamu Mizote, Koichi Maeda, Toru Kuratani, Yoshiki Sawa, Yasushi Sakata
Transcatheter aortic valve implantation (TAVI) is an effective and less invasive treatment for the increasing population of individuals with severe aortic stenosis (AS). Echocardiography is crucial in the assessment of AS patients from pre- to post-procedure. Transthoracic echocardiography (TTE) may be used to assess patient suitability for TAVI, as well as evaluate the severity of AS, the aortic valve complex, aortic valve morphology, mitral regurgitation (MR), and left ventricular function. Transesophageal echocardiography (TEE) is usually used as an intra-procedural monitoring tool to provide feedback during the procedure, to assess prosthetic valve function, and to detect complications rapidly before and after balloon aortic valvuloplasty (BAV) or transcatheter heart valve (THV) deployment...
February 2018: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29532388/mosquito-associated-viruses-in-china
#20
Han Xia, Yujuan Wang, Evans Atoni, Bo Zhang, Zhiming Yuan
Mosquitoes are classified into approximately 3500 species and further grouped into 41 genera. Epidemiologically, they are considered to be among the most important disease vectors in the world and they can harbor a wide variety of viruses. Several mosquito viruses are considered to be of significant medical importance and can cause serious public health issues throughout the world. Such viruses are Japanese encephalitis virus (JEV), dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV). Others are the newly recognized mosquito viruses such as Banna virus (BAV) and Yunnan orbivirus (YNOV) with unclear medical significance...
March 12, 2018: Virologica Sinica
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