Luciana Santos de Oliveira, Thayna Queiroz Menezes da Silva, Erikles Macedo Barbosa, Jeane Martinha Dos Anjos Cordeiro, Luciano Cardoso Santos, Patrícia Costa Henriques, Bianca Reis Santos, Daniela de Oliveira Gusmao, Isabella Oliveira de Macedo, Raphael Escorsim Szawka, Juneo Freitas Silva
Background: Hypothyroidism causes ovarian dysfunction and infertility in women, in addition to being associated with hyperprolactinemia and reduced hypothalamic expression of kisspeptin (Kp). However, it remains unknown whether and how Kp is able to reverse the ovarian dysfunction caused by hypothyroidism. Methods: Hypothyroidism was induced in adult female Wistar rats using 6-propyl-2-thiouracil for 3 months. In the last month, half of the animals received Kp10. Blood samples were collected for dosage of free thyroxine, thyrotropin (TSH), luteinizing hormone (LH), prolactin (PRL), progesterone (P4 ), and estradiol (E2 ), and uteruses and ovaries were collected for histomorphometry...
August 16, 2022: Thyroid: Official Journal of the American Thyroid Association