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https://www.readbyqxmd.com/read/27760016/estradiol-reduces-connexin43-gap-junctions-in-the-uterus-during-adenomyosis-in-cows
#1
A J Korzekwa, M Łupicka, B M Socha, A A Szczepańska
Adenomyosis is defined as the presence of glandular foci external to the endometrium of the uterus, either in the myometrium or/and perimetrium, depending on the progress of this dysfunction. To date, we showed that steroids secretion and prolactin expression and proliferative processes are disturbed during uterine adenomyosis in cows. During endometriosis in eutopic endometrium in women, gap junctions are down regulated. The transmembrane gap junction protein, connexin (Cx43) is necessary for endometrial morphological, biochemical and angiogenic functions...
September 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27688161/prenatal-alcohol-exposure-and-pair-feeding-differentially-impact-puberty-and-reproductive-development-in-female-rats-role-of-the-kisspeptin-system
#2
Joanna Helena Sliwowska, Wendy L Comeau, Tamara S Bodnar, Linda Ellis, Joanne Weinberg
BACKGROUND: Reproductive maturation is initiated with the onset of puberty, which activates the hypothalamic-pituitary-gonadal axis and coincidences with increased expression of the hormone kisspeptin within the hypothalamus. Maturational events are sensitive to environmental factors, including alcohol, which is known to delay reproductive development. We hypothesized that, similar to alcohol's adverse effects during reproductive maturation, prenatal alcohol exposure (PAE) would alter pubertal markers, sex hormone profiles, and kisspeptin expression in the hypothalamus...
September 30, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27629133/comparison-of-uterine-endometrial-and-ovarian-blood-flow-by-transvaginal-color-doppler-ultrasound-in-ovulatory-and-anovulatory-cycles
#3
Ozan Dogan, Ahmet Yildiz, Osman Temizkan, Cigdem Pulatoglu
OBJECTIVES: Blood flow to uterus and ovaries is demonstrated to be altered during mensturation. Studies has been published stating that blood flow differs also in ovulatory and anovulatory cycles. In this study, using color Doppler ultrasound, we aim to compare uterine, endometrial and ovarian blood flow during ovulatory and anovulatory cycles. MATERIAL AND METHODS: Women volunteers who are aged between 18-40 had no endocrinological problem and not recieving exogenous hormone therapy were included to study...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/27591979/prolactin-role-in-the-bovine-uterus-during-adenomyosis
#4
M Łupicka, B M Socha, A A Szczepańska, A J Korzekwa
Adenomyosis is uterine dysfunction defined as the presence of endometrial glands within the myometrium. It is suggested that adenomyosis is estrogen-dependent pathology, and prolactin (PRL) also affects its development. In the uterus of ruminants, PRL stimulates gland proliferation and function. We hypothesized that in the bovine uterus, the expression of PRL and its receptors (PRLRs) during adenomyosis is disturbed and modulated by estradiol (E2). Uterine tissues were collected postmortem from cows; epithelial, stromal, and myometrial cells were isolated; and cultured and treated with E2...
January 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27508025/effects-of-pterostilbene-on-treating-hyperprolactinemia-and-related-mechanisms
#5
Haoru Zhang, Changhua Wang, Xiaokun Li, Yong Zhang
Hyperprolactinemia (HPRL) frequently causes primary menopause and reproductive disorders. Pterostilbene is known to have anti-inflammation and modulation on cell apoptosis. However, its role in treating HPRL and potential mechanisms remain unclear yet. Healthy female virgin SD rats were randomly assigned into control, HPRL model group, bromocriptine treatment group, and low (20 mg/kg) and high (40 mg/kg) pterostilbene treatment groups. All groups except control ones received metoclopramide hydrochloride injection for generating HPRL model...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27503621/first-evidence-of-a-menstruating-rodent-the-spiny-mouse%C3%A2-acomys%C3%A2-cahirinus
#6
Nadia Bellofiore, Stacey J Ellery, Jared Mamrot, David W Walker, Peter Temple-Smith, Hayley Dickinson
BACKGROUND: Advances in research relating to menstruation and associated disorders (eg, endometriosis and premenstrual syndrome) have been hindered by the lack of an appropriate animal model. Menstruation, the cyclical shedding of the decidualized endometrium in the absence of pregnancy, is believed to be limited to 78 higher-order primates (human beings and Old World monkeys), 4 species of bat, and the elephant shrew. This represents only 1.5% of the known 5502 mammalian species and <0...
August 5, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27470501/a-role-for-the-endocannabinoid-system-in-premature-luteal-regression-and-progesterone-withdrawal-in-lipopolysaccharide-induced-early-pregnancy-loss-model
#7
Julieta Aylen Schander, Fernando Correa, María Victoria Bariani, Julieta Blanco, Cora Cymeryng, Federico Jensen, Manuel Luis Wolfson, Ana María Franchi
STUDY QUESTION: What is the role of the endocannabinoid system (eCS) in the alterations of the endocrine system in a murine model of lipopolysaccharide (LPS)-induced miscarriage? SUMMARY ANSWER: In 7-days pregnant wild type, but not cannabinoid receptor type 1 knock-out (CB1-KO) mice, LPS increased COX-2 expression and prostaglandin F2α (PGF2α) production in the uterus leading to lower expression of prolactin receptor in the ovary and a marked regression of corpora lutea (CL), suggesting that the eCS mediates the deleterious effects of LPS on reproductive events...
July 28, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27449513/genome-wide-association-mapping-for-female-infertility-in-inbred-mice
#8
Ji-Long Liu, Tong-Song Wang, Miao Zhao
The genetic factors underlying female infertility in humans are only partially understood. Here, we performed a genome-wide association study of female infertility in 25 inbred mouse strains by using publicly available SNP data. As a result, a total of four SNPs were identified after chromosome-wise multiple test correction. The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 (SKI family transcriptional corepressor 2). The second SNP rs30415957 resides in the intron of Plce1 (phospholipase C epsilon 1)...
2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27256631/in-vivo-xenoestrogenic-actions-of-cadmium-and-arsenic-in-anterior-pituitary-and-uterus
#9
Sonia A Ronchetti, Gisela V Novack, María S Bianchi, Melisa C Crocco, Beatriz H Duvilanski, Jimena P Cabilla
Cadmium (Cd) and arsenic (iAs) are toxic metals ubiquitously present in the environment. Both pollutants exert nonmonotonic dose responses, being mostly cytotoxic at high concentrations but mimicking estrogen (E2) effects at low doses. Xenoestrogenic activity of Cd and iAs has been demonstrated in different hormone-dependent tumor cell lines; however, their actions in vivo remain largely unknown. Here, we investigated whether in vivo administration of low doses of Cd and iAs through drinking water would display xenoestrogenic effects in the anterior pituitary gland and uterus of ovariectomized rats...
July 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27226312/polyamine-mediated-effects-of-prolactin-dictate-emergence-from-mink-obligate-embryonic-diapause
#10
Jane C Fenelon, Arnab Banerjee, Pavine Lefèvre, Fanélie Gratian, Bruce D Murphy
Embryonic diapause is an evolutionary strategy to ensure that offspring are born when maternal and environmental conditions are optimal for survival. In many species of carnivores, obligate embryonic diapause occurs in every gestation. Reciprocal embryo transplant studies indicate that embryo arrest during diapause is conferred by uterine conditions and is due to a lack of specific factors necessary for continued development. In previous studies, global gene expression analysis revealed reduced uterine expression during diapause of a cluster of genes in the mink that regulate the abundance of polyamines, including ornithine decarboxylase 1 (ODC1)...
July 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/26987819/uterine-prx2-restrains-decidual-differentiation-through-inhibiting-lipolysis-in-mice
#11
Yufei Jiang, Shuangbo Kong, Bo He, Bingyan Wang, Haibin Wang, Jinhua Lu
Uterine decidualization, characterized as extensive stromal cell proliferation, differentiation and polyploidization, is a crucial event for successful pregnancy and is tightly regulated by many different molecules and pathways. Prx2, an evolutionarily conserved homeobox transcription factor expressed in both embryos and adults, plays an important role during mesenchymal cell differentiation. However, it remains unclear what the exact function of Prx2 is in the uterine stromal cells, one type of mesenchymal cells...
August 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/26985002/a-prolactin-family-paralog-regulates-placental-adaptations-to-a-physiological-stressor
#12
Pengli Bu, Sheikh M Khorshed Alam, Pramod Dhakal, Jay L Vivian, Michael J Soares
The prolactin (PRL) family of hormones and cytokines participates in the regulation of optimal reproductive performance in the mouse and rat. Members of the PRL family are expressed in the anterior pituitary, uterus, and/or placenta. In the present study, we investigated the ontogeny of PRL family 7, subfamily b, member 1 (PRL7B1; also called PRL-like protein-N, PLP-N) expression in the developing mouse placenta and established a mouse model for investigating the biological function of PRL7B1. Transcripts for Prl7b1 were first detected on Gestation Day (d) 8...
May 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/26946522/expression-of-17-hydroxysteroid-dehydrogenase-and-the-effects-of-lh-fsh-and-prolactin-on-oestrone-and-17-oestradiol-secretion-in-the-endometrium-of-pigs-during-early-pregnancy-and-the-oestrous-cycle
#13
B Wojciechowicz, G Kotwica, K Zglejc, E Waszkiewicz, A Franczak
The endometrium of pregnant and cyclic pigs is a source of oestrone (E1) and 17β-oestradiol (E2). However, the roles of LH, FSH and prolactin (PRL) as regulators of endometrial steroidogenesis, and the presence of 17β-hydroxysteroid dehydrogenase (17β-HSD) in the porcine endometrium, remain unknown. Therefore, in the present study we examined 17β-HSD expression and the effects of LH, FSH and PRL on E1 and E2 release in vitro in endometrial explants harvested from gravid pigs on Days 10-11 (embryo migration within the uterus), 12-13 (maternal recognition of pregnancy) and 15-16 (beginning of implantation) and compared them with results obtained in non-gravid pigs...
March 7, 2016: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/26811345/endocrine-disruption-and-oxidative-stress-implications-of-artemether-lumefantrine-combination-therapy-in-the-ovary-and-uterus-of-rats
#14
A O Abolaji, O A Adesanoye, I Awogbindin, E O Farombi
In the current study, we evaluated the endocrine disruption effect and oxidative stress implication of therapeutic dose of artemether-lumefantrine combination therapy on the ovary and uterus of rats. In this respect, female rats were divided into four groups: animals were per orally treated with tween 80 (control), artemether (4 mg kg(-1) body weight), lumefantrine (24 mg kg(-1) body weight) and artemether-lumefantrine (artemether, 4 mg kg(-1) body weight and lumefantrine, 24 mg kg(-1) body weight). We found that therapeutic doses of the drugs did not change the levels of ovarian hydrogen peroxide (H2O2) and malondialdehyde (MDA), but increased uterine levels of H2O2 and MDA and reduced ovarian and uterine levels of reduced glutathione...
January 25, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/26578367/long-term-exposure-to-electromagnetic-radiation-from-mobile-phones-and-wi-fi-devices-decreases-plasma-prolactin-progesterone-and-estrogen-levels-but-increases-uterine-oxidative-stress-in-pregnant-rats-and-their-offspring
#15
Murat Yüksel, Mustafa Nazıroğlu, Mehmet Okan Özkaya
UNLABELLED: We investigated the effects of mobile phone (900 and 1800 MHz)- and Wi-Fi (2450 MHz)-induced electromagnetic radiation (EMR) exposure on uterine oxidative stress and plasma hormone levels in pregnant rats and their offspring. Thirty-two rats and their forty newborn offspring were divided into the following four groups according to the type of EMR exposure they were subjected to: the control, 900, 1800, and 2450 MHz groups. Each experimental group was exposed to EMR for 60 min/day during the pregnancy and growth periods...
May 2016: Endocrine
https://www.readbyqxmd.com/read/26327279/reversibility-of-dopamine-receptor-antagonist-induced-hyperprolactinemia-and-associated-histological-changes-in-tg-rash2-wild-type-mice
#16
Gopala Krishna, Shivaputhrappa Ganiger, Kamala Kannan, Gopa Gopalakrishnan, Saryu Goel
The purpose of this study was to better understand the biological effects of increased prolactin levels induced in mice by dopamine D2 receptor antagonist molindone treatment. Toxicokinetics, prolactin levels, and reproductive tissue histology were evaluated in Tg rasH2 wild-type mice treated orally with molindone at 0, 5, 15, and 50mg/kg/day for 6 months, followed by a 2-month posttreatment recovery period. A greater than dose-proportional increase in molindone exposure ([AUC]0‒24) was observed on Day 180 for both sexes...
December 2015: Reproductive Toxicology
https://www.readbyqxmd.com/read/26247969/folate-deficiency-could-restrain-decidual-angiogenesis-in-pregnant-mice
#17
Yanli Li, Rufei Gao, Xueqing Liu, Xuemei Chen, Xinggui Liao, Yanqing Geng, Yubin Ding, Yingxiong Wang, Junlin He
The mechanism of birth defects induced by folate deficiency was focused on mainly in fetal development. Little is known about the effect of folate deficiency on the maternal uterus, especially on decidual angiogenesis after implantation which establishes vessel networks to support embryo development. The aim of this study was to investigate the effects of folate deficiency on decidual angiogenesis. Serum folate levels were measured by electrochemiluminescence. The status of decidual angiogenesis was examined by cluster designation 34 (CD34) immunohistochemistry and the expression of angiogenic factors, including vascular endothelial growth factor A (VEGFA), placental growth factor (PLGF), and VEGF receptor 2 (VEGFR2) were also tested...
August 4, 2015: Nutrients
https://www.readbyqxmd.com/read/26239213/chlorpromazine-induced-hyperprolactinemia-on-rat-s-uterus
#18
Zahra Zamani, Samad Zare, Rajabali Sadrkhanlou, Abbas Ahmadi, Elham Movahed
BACKGROUND: Hyperprolactinemia is a common side effect of antipsychotic drugs that requires further investigation. The current study was designed to evaluate dose-dependent effect of chlorpromazine (CPZ) on hormonal changes and uterine horn histological structure in rats. Moreover, the mammary glands were analyzed to show hyperprolactinemia-induced histological changes. METHODS: Albino Wistar rats (n = 32) were divided into four groups. The first group was set as a control...
2015: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/26177656/uterine-size-and-ovarian-size-in-adolescents-with-functional-hypothalamic-amenorrhoea
#19
Zana Bumbuliene, Jelena Klimasenko, Diana Sragyte, Jolita Zakareviciene, Grazina Drasutiene
INTRODUCTION: Functional hypothalamic amenorrhoea (FHA) is a condition characterised by the absence of menses due to suppression of the hypothalamic-pituitary-ovarian axis. OBJECTIVE: The purpose of the study was to estimate uterine and ovarian sizes in adolescents with FHA and to compare these results with findings in peers having regular menstrual cycles. DESIGN: Prospective case-controlled study. SETTINGS: Vilnius University Hospital Santariskiu Klinikos, Lithuania...
October 2015: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/25796285/arginine-supplementation-between-41-and-146-days-of-pregnancy-reduces-uterine-blood-flow-in-dairy-heifers
#20
C Yunta, K A Vonnahme, B R Mordhost, D M Hallford, C O Lemley, C Parys, A Bach
We hypothesized that arginine (Arg) supplementation during early pregnancy could foster placental vascularization. The objective of this study was to evaluate the effects of Arg supplementation on uterine artery hemodynamics between 40 and 140 days of gestation. At 41 days of gestation, 17 Holstein heifers (448 ± 73.9 kg) were surgically fitted with a catheter in the peritoneal cavity. After surgery, nine heifers received a daily intraperitoneal infusion of 40 mg of Arg/kg of body weight (BW; ARG), whereas the remaining eight heifers received a daily intraperitoneal infusion of saline solution at equivalent volumes as ARG heifers relative to BW (CTRL)...
July 1, 2015: Theriogenology
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