keyword
https://read.qxmd.com/read/38547092/oxidative-study-a-pilot-prospective-observational-cohort-study-protocol-examining-the-influence-of-peri-reperfusion-hyperoxemia-and-immune-dysregulation-on-early-allograft-dysfunction-after-orthotopic-liver-transplantation
#1
JOURNAL ARTICLE
Elizabeth A Wilson, Anna Woodbury, Kirsten M Williams, Craig M Coopersmith
Early allograft dysfunction (EAD) is a functional hepatic insufficiency within a week of orthotopic liver transplantation (OLT) and is associated with morbidity and mortality. The etiology of EAD is multifactorial and largely driven by ischemia reperfusion injury (IRI), a phenomenon characterized by oxygen scarcity followed by paradoxical oxidative stress and inflammation. With the expanded use of marginal allografts more susceptible to IRI, the incidence of EAD may be increasing. This necessitates an in-depth understanding of the innate molecular mechanisms underlying EAD and interventions to mitigate its impact...
2024: PloS One
https://read.qxmd.com/read/38542516/gender-specific-renoprotective-pathways-in-%C3%AE-mupa-transgenic-mice-subjected-to-acute-kidney-injury
#2
JOURNAL ARTICLE
Heba Abd Alkhaleq, Shadi Hamoud, Israel Hacker, Tony Karram, Ahmad Fokra, Aviva Kabala, Zaid Abassi
Acute kidney injury (AKI) is a serious health concern with high morbidity and high mortality worldwide. Recently, sexual dimorphism has become increasingly recognized as a factor influencing the severity of the disease. This study explores the gender-specific renoprotective pathways in αMUPA transgenic mice subjected to AKI. αMUPA transgenic male and female mice were subjected to ischemia-reperfusion (I/R)-AKI in the presence or absence of orchiectomy, oophorectomy, and L-NAME administration. Blood samples and kidneys were harvested 48 h following AKI for the biomarkers of kidney function, renal injury, inflammatory response and intracellular pathway sensing of or responding to AKI...
March 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542129/sex-specific-effects-of-estradiol-and-progesterone-in-ischemic-kidney-injury
#3
JOURNAL ARTICLE
Nadezda V Andrianova, Anna A Brezgunova, Marina I Buyan, Ciara I Makievskaya, Andrey I Buyan, Kseniia S Cherkesova, Irina B Pevzner, Ljubava D Zorova, Dmitry B Zorov, Egor Y Plotnikov, Vasily A Popkov
The positive effects of female sex hormones, particularly estradiol and progesterone, have been observed in treatment of various pathologies. Acute kidney injury (AKI) is a common condition in hospitalized patients in which the molecular mechanisms of hormone action are poorly characterized. In this study, we investigated the influence of estradiol and progesterone on renal cells during ischemic injury. We performed both in vivo experiments on female and male rats and in vitro experiments on renal tubular cells (RTCs) obtained from the kidneys of intact animals of different sexes...
March 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38539867/beyond-mortality-exploring-the-influence-of-plant-phenolics-on-modulating-ferroptosis-a-systematic-review
#4
REVIEW
Nemanja Živanović, Marija Lesjak, Nataša Simin, Surjit K S Srai
Ferroptosis is a recently discovered type of programmed cell death that is mechanistically different from other types of programmed cell death such as apoptosis, necroptosis, and autophagy. It is characterized by the accumulation of intracellular iron, overproduction of reactive oxygen species, depletion of glutathione, and extensive lipid peroxidation of lipids in the cell membrane. It was discovered that ferroptosis is interconnected with many diseases, such as neurodegenerative diseases, ischemia/reperfusion injury, cancer, and chronic kidney disease...
March 10, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539832/antioxidant-systems-as-modulators-of-ferroptosis-focus-on-transcription-factors
#5
REVIEW
Carolina Punziano, Silvia Trombetti, Elena Cesaro, Michela Grosso, Raffaella Faraonio
Ferroptosis is a type of programmed cell death that differs from apoptosis, autophagy, and necrosis and is related to several physio-pathological processes, including tumorigenesis, neurodegeneration, senescence, blood diseases, kidney disorders, and ischemia-reperfusion injuries. Ferroptosis is linked to iron accumulation, eliciting dysfunction of antioxidant systems, which favor the production of lipid peroxides, cell membrane damage, and ultimately, cell death. Thus, signaling pathways evoking ferroptosis are strongly associated with those protecting cells against iron excess and/or lipid-derived ROS...
February 28, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38537579/bet-inhibitor-nanotherapy-halts-kidney-damage-and-reduces-chronic-kidney-disease-progression-after-ischemia-reperfusion-injury
#6
JOURNAL ARTICLE
Maria Laura Saiz, Laura Lozano-Chamizo, Aida Bernardo Florez, Marzia Marciello, Paula Diaz-Bulnes, Viviana Corte-Iglesias, Cristian Ruiz Bernet, Raul R Rodrigues-Diez, Cristina Martin-Martin, Mar Rodriguez-Santamaria, Ivan Fernandez-Vega, Ramon M Rodriguez, Carmen Diaz-Corte, Beatriz Suarez-Alvarez, Marco Filice, Carlos Lopez-Larrea
Targeting epigenetic mechanisms has emerged as a potential therapeutic approach for the treatment of kidney diseases. Specifically, inhibiting the bromodomain and extra-terminal (BET) domain proteins using the small molecule inhibitor JQ1 has shown promise in preclinical models of acute kidney injury (AKI) and chronic kidney disease (CKD). However, its clinical translation faces challenges due to issues with poor pharmacokinetics and side effects. Here, we developed engineered liposomes loaded with JQ1 with the aim of enhancing kidney drug delivery and reducing the required minimum effective dose by leveraging cargo protection...
March 26, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38530256/tolerogenic-cd11c-dendritic-cells-regulate-cd4-tregs-in-replacing-delayed-ischemic-preconditioning-to-alleviate-ischemia-reperfusion-acute-kidney-injury
#7
JOURNAL ARTICLE
Pingping Wang, Chunyao Li, Tao Peng, Longzhu Ruan, Aijie Wu, Jiaojiao Zhu, Wenlu Shi, Menghua Chen, Ting Zhang
Ischemia-reperfusion injury (IRI) is one of the primary clinical causes of acute kidney injury (AKI). The key to IRI lies in immune-inflammatory damage, where dendritic cells (DCs) play a central role in eliciting immune responses within the context of inflammation induced by ischemia-reperfusion. Our previous study has confirmed that delayed ischemic preconditioning (DIPC) can reduce the kidney injury by mediating DCs to regulate T-cells. However, the clinical feasibility of DIPC is limited, as pre-clamping of the renal artery is not applicable for the prevention and treatment of ischemia-reperfusion acute kidney injury (I/R-AKI) in clinical patients...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38526145/hyaluronidase-inhibitor-sha2-75-alleviates-ischemia-reperfusion-induced-acute-kidney-injury
#8
JOURNAL ARTICLE
Yang Zhang, Huajiang Zhao, Jing Zhang
Hyaluronidases (HAases) are enzymes that degrade hyaluronic acid (HA) in the animal kingdom. The HAases-HA system is crucial for HA homeostasis and plays a significant role in biological processes and extracellular matrix (ECM)-related pathophysiological conditions. This study aims to explore the role of inhibiting the HAases-HA system in acute kidney injury (AKI). We selected the potent inhibitor "sHA2.75" to inhibit HAase activity through mixed inhibitory mechanisms. The ischemia-reperfusion mouse model was established using male BALB/c mice (7-9 weeks old), and animals were subjected to subcapsular injection with 50 mg/kg sHA2...
March 25, 2024: Cell Cycle
https://read.qxmd.com/read/38521405/hypermethylation-leads-to-the-loss-of-hoxa5-resulting-in-jag1-expression-and-notch-signaling-contributing-to-kidney-fibrosis
#9
JOURNAL ARTICLE
Xiao Xiao, Wei Wang, Chunyuan Guo, Jiazhu Wu, Sheng Zhang, Huidong Shi, Sangho Kwon, Jiankang Chen, Zheng Dong
Epigenetic regulations, including DNA methylation, are critical to the development and progression of kidney fibrosis, but the underlying mechanisms remain elusive. Here, we show that fibrosis of the mouse kidney was associated with the induction of DNA methyltransferases and increases in global DNA methylation and was alleviated by the DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine (5-Aza). Genome wide analysis demonstrated the hypermethylation of 94 genes in mouse unilateral ureteral obstruction kidneys, which was markedly reduced by 5-Aza...
March 21, 2024: Kidney International
https://read.qxmd.com/read/38518851/selenium-binding-protein-1-protects-renal-tubular-epithelial-cells-from-ferroptosis-by-upregulating-glutathione-peroxidase-4
#10
JOURNAL ARTICLE
Weihao Zhao, David J Nikolic-Paterson, Ke Li, Yan Li, Yinhong Wang, Xianghui Chen, Zhaoyang Duan, Yuzhan Zhang, Pengfei Liu, Shemin Lu, Rongguo Fu, Lifang Tian
Ferroptosis is a form of programmed cell death involved in various types of acute kidney injury (AKI). It is characterized by inactivation of the selenoprotein, glutathione peroxidase 4 (GPX4), and upregulation of acyl-CoA synthetase long-chain family member 4 (ACSL4). Since urinary selenium binding protein 1 (SBP1/SELENBP1) is a potential biomarker for AKI, this study investigated whether SBP1 plays a role in AKI. First, we showed that SBP1 is expressed in proximal tubular cells in normal human kidney, but is significant downregulated in cases of AKI in association with reduced GPX4 expression and increased ACSL4 expression...
March 20, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38516890/transient-inhibition-of-sodium-glucose-cotransporter-2-after-ischemia-reperfusion-injury-ameliorates-chronic-kidney-disease
#11
JOURNAL ARTICLE
Miguel Ángel Martínez-Rojas, Hiram Balcázar, Isaac González-Soria, Jesús Manuel González-Rivera, Mauricio E Rodríguez-Vergara, Laura A Velazquez-Villegas, Juan Carlos León-Contreras, Rosalba Pérez-Villalva, Francisco Correa, Florencia Rosetti, Norma A Bobadilla
Sodium-glucose cotransporter 2 (SGLT2) inhibitor, dapagliflozin (Dapa), exhibited nephroprotective effects in patients with chronic kidney disease (CKD). We assessed the efficacy of short-term Dapa administration following acute kidney injury (AKI) in preventing CKD. Male Wistar rats were randomly assigned to Sham surgery, bilateral ischemia for 30 minutes (abbreviated as IR), and IR + Dapa groups. Daily treatment with Dapa was initiated just 24 hours after IR and maintained for only 10 days. Initially, rats were euthanized at this point to study early renal repair...
February 22, 2024: JCI Insight
https://read.qxmd.com/read/38511219/parental-obesity-predisposes-offspring-to-kidney-dysfunction-and-increased-susceptibility-to-ischemia-reperfusion-injury-in-a-sex-dependent-manner
#12
JOURNAL ARTICLE
Jussara M do Carmo, John E Hall, Xuemei Dai, Nikaela Aitken, Kylie Larson, Emilio M Luna-Suarez, Zhen Wang, Ana C M Omoto, Alan Mouton, Xuan Li, Luzia N S Furukawa, Viktoria Woronik, Alexandre A da Silva
Although obesity is recognized as a risk factor for cardiorenal and metabolic diseases, the impact of parental obesity on the susceptibility of their offspring to renal injury at adulthood is unknown. We examined the impact of parental obesity on offspring kidney function, morphology, and markers of kidney damage after acute kidney injury (AKI). Offspring from normal (N) diet-fed C57BL/6J parents were fed either N (NN) or a high fat (H) diet (NH) from weaning until adulthood. Offspring from obese H diet-fed parents were fed N (HN) or H diet (HH) after weaning...
March 21, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38509215/extracellular-vesicles-secreted-from-mesenchymal-stem-cells-ameliorate-renal-ischemia-reperfusion-injury-by-delivering-mir-100-5p-targeting-fkbp5-akt-axis
#13
JOURNAL ARTICLE
Guo Chen, Xinyuan Li, Xiang Zhou, Yang Li, Haitao Yu, Xiang Peng, Xuesong Bai, Chunlin Zhang, Zhenwei Feng, Yuhua Mei, Li Li, Yu Liu, Xin Gou, Yuanbin Jiang
The incidence of acute kidney injury (AKI) due to ischemia-reperfusion (IR) injury is increasing. There is no effective treatment for AKI, and because of this clinical challenge, AKI often progresses to chronic kidney disease, which is closely associated with poor patient outcomes and high mortality rates. Small extracellular vesicles from human umbilical cord mesenchymal stem cells (hUCMSC-sEVs) play increasingly vital roles in protecting tissue function from the effects of various harmful stimuli owing to their specific biological features...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38508097/1-phosphate-receptor-agonists-a-promising-therapeutic-avenue-for-ischemia-reperfusion-injury-management
#14
REVIEW
Linyuan Wang, Xiaowen Zhang, Chunyan Ma, Nan Wu
Ischemia-reperfusion injury (IRI) - a complex pathological condition occurring when blood supply is abruptly restored to ischemic tissues, leading to further tissue damage - poses a significant clinical challenge. Sphingosine-1-phosphate receptors (S1PRs), a specialized set of G-protein-coupled receptors comprising five subtypes (S1PR1 to S1PR5), are prominently present in various cell membranes, including those of lymphocytes, cardiac myocytes, and endothelial cells. Increasing evidence highlights the potential of targeting S1PRs for IRI therapeutic intervention...
March 19, 2024: International Immunopharmacology
https://read.qxmd.com/read/38506705/single-cell-rna-sequencing-identifies-response-of-renal-lymphatic-endothelial-cells-to-acute-kidney-injury
#15
JOURNAL ARTICLE
Heidi A Creed, Saranya Kannan, Brittany L Tate, David Godefroy, Priyanka Banerjee, Brett M Mitchell, Ebba Brakenhielm, Sanjukta Chakraborty, Joseph M Rutkowski
SIGNIFICANCE STATEMENT: The renal lymphatic vasculature and the lymphatic endothelial cells that make up this network play important immunomodulatory roles during inflammation. How lymphatics respond to AKI may affect AKI outcomes. The authors used single-cell RNA sequencing to characterize mouse renal lymphatic endothelial cells in quiescent and cisplatin-injured kidneys. lymphatic endothelial cell gene expression changes were confirmed in ischemia-reperfusion injury and in cultured lymphatic endothelial cells, validating renal lymphatic endothelial cells single-cell RNA sequencing data...
February 7, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38505676/protective-effects-of-limb-remote-ischemic-per-conditioning-on-the-heart-injury-induced-by-renal-ischemic-reperfusion-through-the-interaction-of-the-apelin-with-the-ras-inos-pathway
#16
JOURNAL ARTICLE
Sahar Janfeshan, Fatemeh Masjedi, Zeinab Karimi
INTRODUCTION: Remote ischemic conditioning upregulates endogenous protective pathways in response to ischemia-reperfusion injury. This study tested the hypothesis that limb remote ischemic per- conditioning (RIPerC) exerts cardioprotective effects via the renin-angiotensin system (RAS)/inducible nitric oxide synthase (iNOS)/apelin pathway. METHODS: Renal ischemia-reperfusion injury (I/R) was induced by bilateral occlusion of the renal pedicles for 60 minutes, followed by 24 hours of reperfusion; sham-operated rats served as controls...
2024: BioImpacts: BI
https://read.qxmd.com/read/38504554/interleukin-2-anti-interleukin-2-immune-complex-attenuates-cold-ischemia-reperfusion-injury-after-kidney-transplantation-by-increasing-renal-regulatory-t-cells
#17
JOURNAL ARTICLE
Joon Young Jang, Hyung Woo Kim, Ji-Jing Yan, Tae Kyeom Kang, Wook-Bin Lee, Beom Seok Kim, Jaeseok Yang
BACKGROUND: Cold ischemia-reperfusion injury (IRI) is an unavoidable complication of kidney transplantation. We investigated the role of regulatory T cells (Treg) in cold IRI and whether the interleukin (IL)-2/anti-IL-2 antibody complex (IL-2C) can ameliorate cold IRI. METHODS: We developed a cold IRI mouse model using kidney transplantation and analyzed the IL-2C impact on cold IRI in acute, subacute and chronic phases. RESULTS: Treg transfer attenuated cold IRI, while Treg depletion aggravated cold IRI...
March 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38502560/taurine-deficiency-is-a-hallmark-of-injured-kidney-allografts
#18
JOURNAL ARTICLE
Anna Rinaldi, Pietro E Cippà, Ivan Nemazanyy, Dany Anglicheau, Nicolas Pallet
BACKGROUND: Taurine is one of the most abundant amino acids in humans. Low taurine levels are associated with cellular senescence, mitochondrial dysfunction, DNA damage, and inflammation in mouse, all of which can be reversed by supplementation. It is unknown whether taurine metabolism is associated with kidney allograft function and survival. METHODS: We performed urine metabolomic profiling of kidney transplant recipients in the early and late phases after transplantation combined with transcriptomic analysis of human kidney allografts...
March 19, 2024: Transplantation
https://read.qxmd.com/read/38495888/comprehensive-molecular-and-cellular-characterization-of-endoplasmic-reticulum-stress-related-key-genes-in-renal-ischemia-reperfusion-injury
#19
JOURNAL ARTICLE
Hao Zhang, Chaoyue Zheng, Yue Xu, Xiaopeng Hu
BACKGROUND: Renal ischemia-reperfusion injury (RIRI) is an inevitable complication in the process of kidney transplantation and lacks specific therapy. The study aims to determine the underlying mechanisms of RIRI to uncover a promising target for efficient renoprotection. METHOD: Four bulk RNA-seq datasets including 495 renal samples of pre- and post-reperfusion were collected from the GEO database. The machine learning algorithms were utilized to ascertain pivotal endoplasmic reticulum stress genes...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38492877/inhibition-of-both-nox-and-tnf-%C3%AE-exerts-substantial-renoprotective-effects-in-renal-ischemia-reperfusion-injury-rat-model
#20
JOURNAL ARTICLE
Amina A Bayoumi, Enssaf Ahmad Ahmad, Islam A A E-H Ibrahim, Mona F Mahmoud, Mahmoud H Elbatreek
BACKGROUND AND AIMS: Acute kidney injury (AKI) due to renal ischemia-reperfusion injury (RIRI) is associated with high morbidity and mortality, with no renoprotective drug available. Previous research focused on single drug targets, yet this approach has not reached translational success. Given the complexity of this condition, we aimed to identify a disease module and apply a multitarget network pharmacology approach. METHODS: Identification of a disease module with potential drug targets was performed utilizing Disease Module Detection algorithm using NADPH oxidases (NOXs) as seeds...
March 14, 2024: European Journal of Pharmacology
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