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Bile duct cancer treatment

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https://www.readbyqxmd.com/read/29141455/methionine-adenosyltransferases-in-cancers-mechanisms-of-dysregulation-and-implications-for-therapy
#1
Lauren Y Maldonado, Diana Arsene, José M Mato, Shelly C Lu
Methionine adenosyltransferase genes encode enzymes responsible for the biosynthesis of S-adenosylmethionine, the principal biological methyl donor and precursor of polyamines and glutathione. Mammalian cells express three genes - MAT1A, MAT2A, and MAT2B - with distinct expression and functions. MAT1A is mainly expressed in the liver and maintains the differentiated states of both hepatocytes and bile duct epithelial cells. Conversely, MAT2A and MAT2B are widely distributed in non-parenchymal cells of the liver and extrahepatic tissues...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29141394/proximal-resection-margins-more-prognostic-than-distal-resection-margins-in-patients-undergoing-hilar-cholangiocarcinoma-resection
#2
Tae Yoo, Sang-Jae Park, Sung-Sik Han, Seong Hoon Kim, Seung Duk Lee, Tae Hyun Kim, Soon-Ae Lee, Sang Myung Woo, Woo Jin Lee, Eun Kyung Hong
Purpose: Even though the therapeutic gold standard of hilar cholangiocarcinoma(HCCA) resection is cancer-free resection margin(RM), surgical treatment still remains challenging. This study evaluated the prognostic significance of RM status in resected HCCA patients and identified survival prognostic factors. Materials and Methods: We reviewed records of 96 HCCA patients who underwent surgery from 2001 to 2012 and analyzed the RM status and prognostic factors that affecting survival...
November 16, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29121415/efficacy-and-safety-of-trametinib-in-japanese-patients-with-advanced-biliary-tract-cancers-refractory-to-gemcitabine
#3
Masafumi Ikeda, Tatsuya Ioka, Akira Fukutomi, Chigusa Morizane, Akiyoshi Kasuga, Hideaki Takahashi, Akiko Todaka, Takuji Okusaka, Caretha L Creasy, Shelby Gorman, Daniel J Felitsky, Mikiro Kobayashi, Fanghong Zhang, Junji Furuse
Gemcitabine-based therapy remains the mainstay of treatment for patients with biliary tract cancers (BTCs) with no second-line treatment(s) established yet. Aberrant activation of MAPK pathway in patients with BTC indicates its importance in BTC. Trametinib is a potent, highly selective, allosteric non-competitive inhibitor of MEK1/MEK2. In this Phase IIa open-label, single-arm study, we investigated efficacy and safety of trametinib in Japanese patients with advanced BTC refractory to gemcitabine-based therapy...
November 9, 2017: Cancer Science
https://www.readbyqxmd.com/read/29114851/biweekly-cisplatin-and-gemcitabine-in-patients-advanced-biliary-tract-cancer
#4
Daniel H Ahn, Josh Reardon, Chul W Ahn, Manojkumar Bupathi, Sameh Mikhail, Christina Sing-Ying Wu, Tanios Bekaii-Saab
Treatment with cisplatin with gemcitabine (CG) demonstrates a survival benefit in patients with advanced biliary tract cancer (ABTC). However, the weekly administration can add significant toxicities that may prohibit prolonged treatment. Based on previous studies, we implemented a modified biweekly regimen of GC in an attempt to optimize the prescribed regimen with an improved toxicity profile, added convenience to patients while maintaining efficacy. Patients with ABTC were treated with fixed dose rate (FDR) gemcitabine (1000mg/m(2) /min) and cisplatin 20mg/m(2) on days 1 and 15 of every 28-day cycle...
November 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29110582/establishment-of-cholangiocarcinoma-cell-lines-from-patients-in-the-endemic-area-of-liver-fluke-infection-in-thailand
#5
Sunitta Saensa-Ard, Saman Leuangwattanawanit, Laddawan Senggunprai, Nisana Namwat, Sarinya Kongpetch, Yaovalux Chamgramol, Watcharin Loilome, Walaiporn Khansaard, Apinya Jusakul, Auemduan Prawan, Chawalit Pairojkul, Narong Khantikeo, Puangrat Yongvanit, Veerapol Kukongviriyapan
Cholangiocarcinoma is a rare type of cancer which is an increasingly discernible health threat. The disease is usually very difficult in diagnosis and various treatment modalities are typically not effective. Cholangiocarcinoma is a complex and very heterogeneous malignancy characterized by tumor location, different risk factors, molecular profiling, and prognosis. Cancer cell lines represent an important tool for investigation in various aspects of tumor biology and molecular therapeutics. We established two cell lines, KKU-452 and KKU-023, which were derived from patients residing in the endemic area of liver fluke infection in Thailand...
November 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29093418/percutaneous-transhepatic-self-expanding-metallic-stent-placement-for-the-treatment-of-malignant-afferent-loop-obstruction
#6
Naruomi Jinno, Itaru Naitoh, Yoshihito Nagura, Kazutoshi Fujioka, Yusuke Mizuno, Junko Momose, Makoto Ooyama, Kazuki Hayashi, Tomokatsu Miyaki, Makoto Nakamura, Takashi Joh
We report the case of a 71-year-old man with afferent loop obstruction (ALO) after Roux-en-Y reconstruction due to gastric cancer. Computed tomography showed a distended afferent loop and a dilatated bile duct. We could not reach the stricture site in the afferent loop using a gastroscope. We performed percutaneous transhepatic biliary drainage (PTBD) and placed a self-expanding metallic stent (SEMS) in the duodenal stricture through the PTBD route. Although an endoscopic approach is preferable, when PTBD can be performed, percutaneous transhepatic SEMS placement might be an alternative option for treating ALO in cases in which it is not possible to reach the site of stenosis with an endoscope...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29076352/ethnic-disparities-in-cancer-incidence-and-survival-among-the-oldest-old-in-the-united-states
#7
Jessica L Krok-Schoen, Ingrid K Adams, Ryan D Baltic, James L Fisher
OBJECTIVE: To examine potential ethnic disparities in cancer incidence and survival rates among the oldest old using data from the SEER Program. DESIGN: Cases diagnosed with one of the leading four cancer sites (lung and bronchus, colon and rectum, female breast, prostate) and four cancer sites (stomach, liver and intrahepatic bile duct, gallbladder, and cervical) that disproportionally affect Hispanics were reported to one of 18 SEER registries. Differences in cancer incidence were examined for cases aged ≥85 years diagnosed during the most recent 5-year time period (2009-2013) and, to examine changes over time, from 1992 to 2013...
October 27, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/29067113/photodynamic-therapy-for-biliary-tract-organ-via-a-novel-ultra-small-composite-optical-fiberscope
#8
Kazuhiko Kasuya, Kiyoshi Oka, Ryoko Soya, Takaaki Tsuchiya, Takao Itoi, Akihiko Tsuchida
Photodynamic therapy (PDT) is a method used treat tumors via utilizing photodynamic reactions between photosensitive substances with tumor affinity and lasers. For overall bile duct cancers, PDT has been demonstrated to resolve stenosis and improve prognosis; however, when limited to intrahepatic bile duct cancers, modifications to the laser irradiation are necessary as surrounding hepatocytes incorporate a large amount of photosensitive substances. Furthermore, the intrahepatic bile duct is thin, and a guide sheath and thin fiber are necessary to transport laser irradiation probes to the target region...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29063057/clinical-epidemiological-survey-of-gallbladder-carcinoma-in-northwestern-china-2009-2013-2379-cases-in-17-centers
#9
Hao-Xin Shen, Hu-Wei Song, Xin-Jian Xu, Zuo-Yi Jiao, Zhen-Yu Ti, Zhao-Yu Li, Bin Ren, Chen Chen, Li Ma, Ya-Ling Zhao, Guan-Jun Zhang, Jian-Cang Ma, Xi-Lin Geng, Xiao-Di Zhang, Jing-Sen Shi, Lin Wang, Zhi-Min Geng
OBJECTIVE: To analyze the clinical epidemiological characteristics of patients with gallbladder carcinoma recruited from 17 hospitals in five northwestern provinces of China (Shaanxi Province, Gansu Province, Qinghai Province, Ningxia Hui Autonomous Region, and Xinjiang Uygur Autonomous Region) from 2009 to 2013, and to summarize the clinical diagnosis and treatment data of gallbladder carcinoma. METHODS: Clinical information of 2379 patients with gallbladder carcinoma from 17 hospitals in five northwestern provinces of China was retrospectively collected and analyzed using the "Questionnaire for Gallbladder Carcinoma Patients in Northwestern Area of China...
March 25, 2017: Chronic Dis Transl Med
https://www.readbyqxmd.com/read/28974454/sildenafil-protects-against-bile-duct-ligation-induced-hepatic-fibrosis-in-rats-potential-role-for-silent-information-regulator-1-sirt1
#10
Dalia M Abd El Motteleb, Islam A A E-H Ibrahim, Shimaa M Elshazly
Hepatic fibrosis is a potential health problem that may end with life-threatening cirrhosis and primary liver cancer. Recent studies point out to the protective effects of silent information regulator1 (SIRT1), against different models of organs fibrosis. This work aimed to investigate the possible protective effect of sildenafil (SIRT1 activator) against hepatic fibrosis induced by bile duct ligation (BDL). Firstly, three different doses of sildenafil (5, 10, 20mg/kg/day) were investigated; to detect the most protective one against BDL induced liver dysfunction and hepatic fibrosis...
November 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28965488/treatment-of-pruritus-in-a-palliative-care-patient-with-low-dose-paroxetine-a-case-report
#11
Roni Y Kraut
BACKGROUND: Pruritus is a distressing symptom seen in palliative care. There is limited high-quality evidence of pharmaceutical treatments for pruritus in palliative care, including the use of paroxetine. CASE PRESENTATION: I present a case of a 70-year-old caucasian woman with metastatic ovarian cancer who presented with severe pruritus. She had been diagnosed with bile duct obstruction 1 month earlier. Antihistamines and over-the-counter skin creams were first trialed, to no effect...
October 2, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28937265/salvage-radiotherapy-for-locoregionally-recurrent-extrahepatic-bile-duct-cancer-after-radical-surgery
#12
Eunji Kim, Yi-Jun Kim, Kyubo Kim, Changhoon Song, Jae-Sung Kim, Do-Youn Oh, Eun Mi Nam, Eui Kyu Chie
OBJECTIVE: This study evaluated the outcome of salvage radiotherapy for locoregionally recurrent extrahepatic bile duct cancer. METHODS: We performed a retrospective review of 23 extrahepatic bile duct cancer patients who underwent radiotherapy with or without concomitant chemotherapy for isolated locoregional recurrence after radical surgery between August 2001 and September 2013. The median disease-free interval was 11.8 months. Salvage radiotherapy was delivered to the recurrent tumour with or without initial operation bed up to a median dose of 54 Gy (range, 45-60)...
October 9, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28932727/effectiveness-of-cholangioscopy-using-narrow-band-imaging-for-hepatobiliary-malignancies
#13
Ji Woong Jang, Dong Hyo Noh, Kyu-Hyun Paik, Sae Hee Kim, Il-Hyun Paik, Sung Hee Jung
PURPOSE: Recently, cholangioscopy using narrow band imaging (NBI) has been used as a diagnostic modality for better visualization in hepatobiliary malignancies; however, there are few reports on it. Our aim is to evaluate the effectiveness of cholangioscopy using NBI in hepatobiliary malignancies. METHODS: Between January 2007 and December 2016, 152 cholangioscopies using percutaneous approach were conducted in total 123 patients. Among these, 36 patients were suspicious of hepatobiliary malignancies...
September 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28916723/fibroblast-growth-factor-2-fgf2-regulates-cytoglobin-expression-and-activation-of-human-hepatic-stellate-cells-via-jnk-signaling
#14
Misako Sato-Matsubara, Tsutomu Matsubara, Atsuko Daikoku, Yoshinori Okina, Lisa Longato, Krista Rombouts, Le Thi Thanh Thuy, Jun Adachi, Takeshi Tomonaga, Kazuo Ikeda, Katsutoshi Yoshizato, Massimo Pinzani, Norifumi Kawada
Cytoglobin (CYGB) belongs to the mammalian globin family and is exclusively expressed in hepatic stellate cells (HSCs) in the liver. In addition to its gas-binding ability, CYGB is relevant to hepatic inflammation, fibrosis, and cancer because of its antioxidative properties; however, the regulation of CYGB gene expression remains unknown. Here, we sought to identify factors that induce CYGB expression in HSCs and to clarify the molecular mechanism involved. We used the human HSC cell line HHSteC and primary human HSCs isolated from intact human liver tissues...
September 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28913568/piperlongumine-induces-g2-m-phase-arrest-and-apoptosis-in-cholangiocarcinoma-cells-through-the-ros-jnk-erk-signaling-pathway
#15
Sunisa Thongsom, Wipa Suginta, Kyung Jin Lee, Han Choe, Chutima Talabnin
Cholangiocarcinoma (CCA) is an aggressive, metastatic bile duct cancer. CCA is difficult to diagnose, and responds poorly to current radio- and chemo-therapy. Piperlongumine (PL) is a naturally-occurring small molecule selectively toxic to cancer cells by targeting reactive oxygen species (ROS). In this study, we demonstrated the potential anticancer activity of PL in CCA. PL markedly induced death in CCA cell lines in a dose- and time-dependent manner through the activation of caspase-3 and PARP. PL also stimulated ROS accumulation in CCA...
September 14, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28912914/intraductal-ultrasonography-as-a-local-assessment-before-magnetic-compression-anastomosis-for-obstructed-choledochojejunostomy
#16
Hideaki Kawabata, Misuzu Hitomi, Naonori Inoue, Yukino Kawakatsu, Yuji Okazaki, Masatoshi Miyata
Magnetic compression anastomosis (MCA) has been developed as a non-surgical alternative treatment for biliary obstruction without serious complications. A 70-year-old woman who had undergone pancreaticoduodenectomy with modified Child reconstruction for pancreatic head cancer suffered from obstructed choledochojejunostomy with no recurrent findings 4 months after the operation. Cholangiography using the percutaneous transhepatic cholangiographic drainage (PTCD) and fluoroscopy revealed complete obstruction of the upper common bile duct, and the length of the obstruction was 7 mm...
August 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28903446/application-of-embolization-microspheres-in-interventional-therapy-of-malignant-non-hypervascular-tumor-of-liver
#17
Huanzhang Niu, Tingwei Du, Quanping Xiao, Xin Hu, Dongmin Li, Chao Wang, Wanqin Gao, Taohong Xing, Xiangmei Xu
OBJECTIVE: To investigate the efficacy and safety of transarterial embolization (TAE) using embolization microspheres in the treatment of non-hypervascular malignant liver tumors. METHODS: Patients with malignant non-hypervascular liver tumors, who were treated with TAE using embolization microspheres, were selected and analyzed retrospectively. The technical success rate, tumor response, and complications were assessed. RESULTS: Six patients were included in the study: 1 patient each with hepatocellular-cholangiocarcinoma, intrahepatic cholangiocarcinoma, hepatic metastasis after resection of common bile duct carcinoma, liver metastasis from colon cancer, liver metastasis from esophageal cancer, and liver metastasis from pancreatic cancer...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902968/two-step-eus-guided-antegrade-treatment-of-a-difficult-bile-duct-stone-in-a-surgically-altered-anatomy-patient
#18
Yousuke Nakai, Hiroyuki Isayama, Kazuhiko Koike
EUS-guided antegrade (EUS-AG) treatment is a treatment option for bile duct stones (BDS) in surgically altered anatomy patients[1, 2] but can be technically demanding due to the limitation of stone extraction devices[3, 4]. Herein, we presented a case of a difficult BDS successfully removed by two-step EUS-AG treatment after enterobiliary fistula maturation.A 73 year-old male with a history of gastrectomy and Roux-en-Y reconstruction for gastric cancer presented with 12-mm BDS on CT scan (Figure1). This article is protected by copyright...
September 13, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28888976/simple-nanophotosensitizer-fabrication-using-water-soluble-chitosan-for-photodynamic-therapy-in-gastrointestinal-cancer-cells
#19
Young-Il Jeong, Byungyoul Cha, Hye Lim Lee, Yeon Hui Song, Yun Hye Jung, Tae Won Kwak, Changyong Choi, Gyeong-Won Jeong, Jae Woon Nah, Dae Hwan Kang
The polysaccharide chitosan has abundant cationic amine groups, and can form ion-complexes with anionic molecules such as the strong photosensitizer chlorin e6 (Ce6). In this study, water-soluble chitosan (WSC) was used to fabricate Ce6-incorporated nanophotosensitizers (Abbreviated as ChitoCe6 nanophotosensitizer) via a self-assembling process. This was accomplished by dissolving WSC in pure water and then directly mixing the solution with solid Ce6 causing ion complex formation between WSC and Ce6. The resulting nanophotosensitizer was spherical in shape and had a particle size of less than 300nm...
September 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28855998/surgery-is-the-preferred-treatment-for-bile-duct-hamartomas
#20
Xiao-Yu Yang, Hai-Bo Zhang, Bin Wu, Ai-Jun Li, Xiao-Hui Fu
Bile duct hamartoma (BDH) is a rare liver disease with a rising incidence in recent years. A retrospective study on BDH patients between June 2007 and December 2015 was conducted. All the medical records, including clinical, imaging and pathological characteristics, were retrieved. Follow-up data were obtained by telephone communication. The majority of the patients had no symptoms and the laboratory tests were normal. The appearance on ultrasound examination was variable. The lesion exhibited low density on plain computed tomography and no enhancement in 4 cases, and inhomogeneous enhancement in 1 case...
October 2017: Molecular and Clinical Oncology
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