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Cervix utero neoplasia

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https://www.readbyqxmd.com/read/27759820/disparities-in-cancer-epidemiology-and-care-delivery-among-brazilian-indigenous-populations
#1
Pedro Nazareth Aguiar, Gustavo Trautman Stock, Gilberto de Lima Lopes, Michelle Samora de Almeida, Hakaru Tadokoro, Bárbara de Souza Gutierres, Douglas Antônio Rodrigues
Objective: To assess aspects related to cancer in indigenous population. Methods: This is a retrospective study developed in a public university hospital. We included patients with 18 or more years of age, diagnosed with solid tumors, and followed between 2005 and 2015. Clinical features were assessed by descriptive statistics, and survival was evaluated by Kaplan-Meier curves and multivariate Cox regression. Results: Fifty patients were included...
July 2016: Einstein
https://www.readbyqxmd.com/read/22711081/screening-for-cervical-cancer-u-s-preventive-services-task-force-recommendation-statement
#2
Virginia A Moyer
DESCRIPTION: Update of the 2003 U.S. Preventive Services Task Force (USPSTF) recommendation statement on screening for cervical cancer. METHODS: The USPSTF reviewed new evidence on the comparative test performance of liquid-based cytology and the benefits and harms of human papillomavirus (HPV) testing as a stand-alone test or in combination with cytology. In addition to the systematic evidence review, the USPSTF commissioned a decision analysis to help clarify the age at which to begin and end screening, the optimal interval for screening, and the relative benefits and harms of different strategies for screening (such as cytology and co-testing)...
June 19, 2012: Annals of Internal Medicine
https://www.readbyqxmd.com/read/22422943/screening-for-cervical-cancer-u-s-preventive-services-task-force-recommendation-statement
#3
Virginia A Moyer et al.
Description: Update of the 2003 U.S. Preventive Services Task Force (USPSTF) recommendation statement on screening for cervical cancer. Methods: The USPSTF reviewed new evidence on the comparative test performance of liquid-based cytology and the benefits and harms of human papillomavirus (HPV) testing as a stand-alone test or in combination with cytology. In addition to the systematic evidence review, the USPSTF commissioned a decision analysis to help clarify the age at which to begin and end screening, the optimal interval for screening, and the relative benefits and harms of different strategies for screening (such as cytology and co-testing)...
March 14, 2012: Annals of Internal Medicine
https://www.readbyqxmd.com/read/16445652/detection-of-chromosomal-aberrations-by-fluorescence-in-situ-hybridization-in-cervicovaginal-biopsies-from-women-exposed-to-diethylstilbestrol-in-utero
#4
COMPARATIVE STUDY
R A Hajek, D W King, M A Hernández-Valero, R H Kaufman, J C Liang, J A Chilton, C L Edwards, J T Wharton, L A Jones
Epidemiologic studies have associated estrogens with human neoplasms such as those in the endometrium, cervix, vagina, breast, and liver. Perinatal exposure to natural (17beta-estradiol [17beta-E(2)]) and synthetic (diethylstilbestrol [DES]) estrogens induces neoplastic changes in humans and rodents. Previous studies demonstrated that neonatal 17beta-E(2) treatment of mice results in increased nuclear DNA content of cervicovaginal epithelium that precedes histologically evident neoplasia. In order to determine whether this effect was associated with chromosomal changes in humans, the frequencies of trisomy of chromosomes 1, 7, 11, and 17 were evaluated by the fluorescence in situ hybridization (FISH) technique in cervicovaginal tissue from 19 DES-exposed and 19 control women...
January 2006: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/15886059/cervical-neoplasia-during-pregnancy-diagnosis-management-and-prognosis
#5
REVIEW
K Van Calsteren, I Vergote, F Amant
Pregnancy represents an exceptional opportunity for the early diagnosis of cervical cancer since visual inspection, cytological examination and bimanual palpation are considered to be part of routine antenatal care. An abnormal cervical smear should generally be managed as in the non-pregnant state. However, colposcopy and biopsies are mainly intended to exclude invasive disease because a conservative approach is preferred in cases of pre-invasive disease. The only absolute indication for conization in pregnancy is to rule out (micro-)invasive disease or make the diagnosis of invasive carcinoma when such a diagnosis will alter the timing or mode of delivery...
August 2005: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/15512425/not-just-a-cervical-ectropion-three-case-reports-of-diethylstilbestrol-des-exposed-women-presenting-with-vaginal-discharge-and-cervical-ectropion
#6
M Wingfield
Typical changes in the cervix are described in three women following in utero exposure to diethylstilbestrol. It is important that these changes are recognised on colposcopy and appropriate follow-up colposcopy arranged. In the absence or cervical intraepithelial neoplasia, local destructive therapy is not indicated as this may be associated with cervical stenosis.
November 1999: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/11714112/incidence-of-squamous-neoplasia-of-the-cervix-and-vagina-in-women-exposed-prenatally-to-diethylstilbestrol-united-states
#7
E E Hatch, A L Herbst, R N Hoover, K L Noller, E Adam, R H Kaufman, J R Palmer, L Titus-Ernstoff, M Hyer, P Hartge, S J Robboy
OBJECTIVES: Women exposed prenatally to diethylstibestrol (DES) have an excess risk of clear-cell adenocarcinoma of the vagina and cervix, but the effect on the incidence of squamous neoplasia is uncertain. The purpose of the current study was to evaluate the long-term risk of developing high-grade squamous neoplasia of the genital tract among women exposed prenatally to DES. METHODS: A cohort comprising 3,899 DES-exposed and 1,374 unexposed daughters was followed for 13 years (1982 1995) for pathology-confirmed diagnoses of high-grade squamous intraepithelial neoplasia (HSIL) of the genital tract...
November 2001: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/11018391/incidence-of-squamous-neoplasia-of-the-cervix-and-vagina-in-des-exposed-daughters
#8
Hatch, Herbst, Hoover, Noller, Adam, Kaufman, Palmer, Titus-Ernstoff, Hyer, Robboy
PURPOSE: Women exposed to diethylstibestrol (DES) in utero are known to have an excess risk of clear cell adenocarcinoma of the vagina and cervix, in addition to vaginal epithelial changes, but the effect on the incidence of squamous neoplasia is uncertain. This study evaluated the long-term risk of developing high-grade squamous neoplasia of the genital tract among women exposed prenatally to diethylstilbestrol.METHODS: A cohort comprising 3899 DES-exposed and 1374 unexposed daughters was followed for thirteen years (1982-1995) for pathology-confirmed diagnoses of high-grade squamous neoplasia...
October 1, 2000: Annals of Epidemiology
https://www.readbyqxmd.com/read/8332308/role-of-colposcopy-in-the-examination-of-diethylstilbestrol-exposed-women
#9
REVIEW
K L Noller
Both epithelial and structural abnormalities of the lower genital tract are known to occur in women exposed in utero to DES with greater frequency than in the general population. These changes are usually easily identified by pelvic and colposcopic examination. In general, no treatment is suggested for benign changes. DES-exposed women, however, must be carefully followed-up because of the potential, although rare, of the development of clear cell adenocarcinoma and the increased incidence of squamous intraepithelial neoplasia...
March 1993: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/7195532/cervical-intraepithelial-neoplasia-associated-with-exposure-to-diethylstilbestrol-in-utero-a-clinical-and-pathologic-study
#10
J W Orr, H M Shingleton, H Gore, J M Austin, K D Hatch, S J Soong
The anatomic, colposcopic, cytologic, and histologic findings of the cervix in 300 women exposed to diethylstilbestrol (DES) in utero are reported. Structural cervical abnormalities were found in 51.7% of these patients and an abnormal colposcopic examination was present in 50.6%. The initial interpretation of the pathologic specimens revealed that 26.6% of patients had cytologic or histologic evidence of cervical dysplasia. A uniform pathologic review demonstrated that 10.8% of the cytologic specimens and 37...
July 1981: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/4009562/regression-of-cervicovaginal-abnormalities-in-des-exposed-women-a-comparison-of-changes-in-sexually-inactive-women-and-the-effects-of-the-onset-of-sexual-activity
#11
COMPARATIVE STUDY
A R Frank, B A Krumholz, S Deutsch
Sequential colpophotographs were reviewed from a group of 1,139 female progeny exposed to diethylstilbestrol (DES) in utero and who were not yet sexually active on initial examination. Forty had ectopy. For 27 the normalized yearly rate of squamous metaplasia (replacement of columnar epithelium) was 28.8 +/- 3.7% (SEM). For the 18 who became sexually active the normalized yearly rate of squamous metaplasia was 54.6 +/- 6.2%. Thus, the sexually active women demonstrated a more rapid rate of squamous metaplasia; that rate was statistically significant (T = 3...
May 1985: Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/2829071/development-of-cervical-and-vaginal-squamous-cell-neoplasia-as-a-late-consequence-of-in-utero-exposure-to-diethylstilbestrol
#12
REVIEW
J Bornstein, E Adam, K Adler-Storthz, R H Kaufman
During the last 14 years, several articles have given contradictory reports on prevalence rates of squamous cell neoplasia of the cervix and vagina in diethylstilbestrol (DES)-exposed progeny. In 1984, the DES-Adenosis (DESAD) Project found that the incidence of cervical and vaginal intraepithelial neoplasia in DES-exposed daughters was twice as high as in a comparison group of unexposed women. This was also associated with a higher rate of herpes simplex virus and human papillomavirus infections. Possible hypotheses on the etiology of the increased incidence of squamous neoplasia are discussed...
January 1988: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/2680951/epidemiological-studies-of-the-effects-of-diethylstilboestrol
#13
REVIEW
M P Vessey
Herbst and his colleagues first showed in 1971 that girls born to mothers who had taken diethylstilboestrol (DES) during pregnancy were at an increased risk of clear-cell adenocarcinoma of the vagina and cervix. At first it was feared that these girls would have a high probability of developing clear-cell carcinomas, but the latest report from the Registry for Research on Hormonal Transplacental Carcinogenesis of the University of Chicago puts the risk at only 1 per 1000 of those exposed, from birth through to age 34...
1989: IARC Scientific Publications
https://www.readbyqxmd.com/read/2589438/colposcopic-findings-and-intraepithelial-neoplasia-in-diethylstilbestrol-exposed-offspring-the-dutch-experience
#14
T J Helmerhorst, H J Wijnen, P Kenemans, G S Tjioe, H H Dijkhuizen, J J Calame, H G Stolk
Data from two regional diethylstilbestrol clinics for colposcopic evaluation of young women with a history of diethylstilbestrol exposure in utero are presented: A total of 224 subjects with a well-documented history were enrolled in this study. Structural anomalies of the cervix and vagina were found in 30%. Vaginal epithelial changes were colposcopically observed in 65%, including vaginal adenosis in 22%. The prevalence rate of abnormal cytologic findings in the study group was 9%. In half of these patients a low-grade intraepithelial neoplasia of the cervix and vagina was found...
November 1989: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/2040004/carcinogenicity-of-diethylstilbestrol-in-the-wistar-rat-effect-of-postnatal-oral-contraceptive-steroids
#15
R B Baggs, R K Miller, C L Odoroff
Diethylstilbestrol (DES) has been associated with vaginal neoplasia and malformations in humans. We have studied a test population of 504 female Wistar rats given diethylstilbestrol at from 0.0 to 0.5 mg/kg maternal body weight on days 18, 19, and 20 of gestation. Animals were euthanized in extremis, or at 2 years of age. The incidence of vaginal epithelial tumors was dose related. The types of epithelial tumors of the vagina were adenocarcinoma, squamous cell carcinoma, and mixed carcinoma, containing discrete adenomatous and squamous components...
June 15, 1991: Cancer Research
https://www.readbyqxmd.com/read/717453/vaginal-and-cervical-squamous-cell-dysplasia-in-women-exposed-to-diethylstilbestrol-in-utero
#16
COMPARATIVE STUDY
L Burke, D Antonioli, S Rosen
Two hundred and fifty patients were examined because of a history of in utero exposure to diethylstilbestrol (DES) or because of the presence of physical findings suggesting such exposure. One thousand biopsies were examined for the presence of neoplasia and then compared to the colposcopic findings. There were no cases of glandular or squamous cell carcinoma. Fifteen (6 per cent) of the patients had squamous cell dysplasia. The degree of dysplasia was mild in 11 and moderate in only 4 (1.6 per cent) of the women...
November 1, 1978: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/683639/squamous-cell-carcinoma-in-situ-of-the-vagina-and-cervix-after-intrauterine-des-exposure
#17
N P Veridiano, M L Tancer, E A Weiner
Two patients exposed in utero to maternal DES ingestion presented with adenosis. Each developed intraepithelial neoplasia in an area of active metaplastic change. The question is raised whether a continuum exists beginning with DES exposure and proceeding through the occurrence of adenosis and active squamous metaplasia to dysplastic alteration and finally squamous neoplasia. Since the cytologic smear is negative in 50% of cases during the dysplastic phase, it is recommened that all cases of adenosis be followed by colposcopy...
July 1978: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/662229/in-utero-exposure-to-des-evaluation-and-followup-of-199-women
#18
W C Fowler, D A Edelman
Among 199 women from 12 to 30 years of age who had been exposed to DES in utero, the colposcopic evaluation of the vagina and cervix was considered normal for only 13.6%. The incidence of colposcopically detected lesions was not related to the trimester of DES exposure, the patient's age, use of oral contraceptives, or presenting symptoms. Areas of punctation, mosaic patterns, white epithelium, and keratosis were not considered areas of adenosis. Cervical bands, hoods, cock's combs, etc., were considered as part of the cervix...
April 1978: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/485089/induction-of-urogenital-neoplasia-and-abnormalities-from-prenatal-exposure-to-diethylstilbestrol
#19
M L Netzloff
The occurrence of vaginal clear cell adenocarcinoma in young women following exposure in utero to diethylstilbestrol (DES) is now well documented. In addition to this carcinogenic potential. DES has been shown to be teratogenic. In females, the DES-related malformations include vaginal adenosis, transverse ridges of the vagina or cervix and uterine abnormalities. Although no neoplasms have been observed in DES-exposed males, malformations of the epididymis, testes and phallus are relatively common and may result in infertility...
July 1979: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/212185/role-of-exogenous-female-hormones-in-altering-the-risk-of-benign-and-malignant-neoplasms-in-humans
#20
REVIEW
D B Thomas
The epidemiological and clinical evidence for various forms of exogenous estrogens altering the risk of neoplasms of the female genital system, breast, and liver are reviewed and evaluated. It is virtually certain that in utero exposure to diethylstilbestrol can cause clear cell adenocarcinomas of the vagina and cervix. There is strong evidence that various estrogens given for treatment of menopausal symptoms can cause endometrial carcinoma and that sequential oral contraceptives probably also do so. Oral contraceptives very probably reduce the risk of both cystic disease and fibroadenoma of the breast and increase the risk of liver cell adenomas...
November 1978: Cancer Research
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