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OROS methylphenidate

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https://www.readbyqxmd.com/read/29370538/exploring-longitudinal-course-and-treatment-baseline-severity-interactions-in-secondary-outcomes-of-smoking-cessation-treatment-in-individuals-with-attention-deficit-hyperactivity-disorder
#1
Sean X Luo, Melanie Wall, Lirio Covey, Mei-Chen Hu, Jennifer M Scodes, Frances R Levin, Edward V Nunes, Theresa Winhusen
BACKGROUND: A double blind, placebo-controlled randomized trial (NCT00253747) evaluating osmotic-release oral system methylphenidate (OROS-MPH) for smoking-cessation revealed a significant interaction effect in which participants with higher baseline ADHD severity had better abstinence outcomes with OROS-MPH while participants with lower baseline ADHD severity had worse outcomes. OBJECTIVES: This current report examines secondary outcomes that might bear on the mechanism for this differential treatment effect...
January 25, 2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29359460/resolution-of-methylphenidate-osmotic-release-oral-system-induced-hair-loss-in-two-siblings-after-dose-escalation
#2
Ulku Akyol Ardic, Eyup Sabri Ercan
This report describes the cases of two siblings who experienced hair loss after treatment with methylphenidate (MPH) osmotic release oral system (OROS). Hair loss was resolved after discontinuation of the drug, but the children re-initiated treatment, after which hair loss again occurred, but they continued the treatment. After dose escalation, the hair loss resolved. This is the first report to describe resolution of OROS-MPH-induced hair loss after dose escalation.
November 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28988700/differences-in-adverse-event-reporting-rates-of-therapeutic-failure-between-two-once-daily-extended-release-methylphenidate-medications-in-canada-analysis-of-spontaneous-adverse-event-reporting-databases
#3
Laura Park-Wyllie, Judy van Stralen, Genaro Castillon, Stephen E Sherman, Doron Almagor
PURPOSE: Our study evaluated adverse events of therapeutic failure (and specifically reduced duration of action) with the use of a branded product, Osmotic Release Oral System (OROS) methylphenidate, which is approved for the treatment of attention deficit/hyperactivity disorder, and a generic product (methylphenidate, methylphenidate ER-C), which was approved for marketing in Canada based on bioequivalence to OROS methylphenidate. This study was initiated following reports that some US-marketed generic methylphenidate ER products had substantially higher reporting rates of therapeutic failure than did the referenced brands...
October 5, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28980198/randomized-double-blind-placebo-controlled-acute-comparator-trials-of-lisdexamfetamine-and-extended-release-methylphenidate-in-adolescents-with-attention-deficit-hyperactivity-disorder
#4
Jeffrey H Newcorn, Peter Nagy, Ann C Childress, Glen Frick, Brian Yan, Steven Pliszka
BACKGROUND: Psychostimulants are considered first-line pharmacotherapy for youth with attention-deficit/hyperactivity disorder (ADHD), but questions remain regarding the comparative efficacy of amphetamine- and methylphenidate-based agents. OBJECTIVE: Our objective was to describe two acute randomized, double-blind, placebo-controlled, head-to-head studies of lisdexamfetamine dimesylate (LDX) and osmotic-release oral system methylphenidate (OROS-MPH) in adolescents with ADHD...
November 2017: CNS Drugs
https://www.readbyqxmd.com/read/28710695/serum-brain-derived-neurotrophic-factor-levels-in-treatment-na%C3%A3-ve-boys-with-attention-deficit-hyperactivity-disorder-treated-with-methylphenidate-an-8-week-observational-pretest-posttest-study
#5
Aynur Pekcanlar Akay, Halil Resmi, Sevay Alsen Güney, Handan Özek Erkuran, Gonca Özyurt, Enis Sargin, Ahmet Topuzoglu, Ali Evren Tufan
Brain-derived neurotrophic factor (BDNF) is an important neurotrophin in the brain that modulates dopaminergic neurons. In this study, we aimed to investigate the changes in serum BDNF levels of children with attention-deficit/hyperactivity disorder (ADHD) in response to OROS methylphenidate treatment. We also aimed to determine whether there were any pre-post-differences between ADHD subtypes and comorbid psychiatric disorders in serum BDNF levels. Fifty male children with ADHD and 50 male healthy controls within the age range of 6-12 years were recruited to the study...
July 14, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28651152/methylphenidate-disintegration-from-oral-formulations-for-intravenous-use-by-experienced-substance-users
#6
G D Bjarnadottir, M Johannsson, A Magnusson, B O Rafnar, E Sigurdsson, S Steingrimsson, V Asgrimsson, I Snorradottir, H Bragadottir, H M Haraldsson
BACKGROUND AND AIMS: Methylphenidate (MPH) is a prescription stimulant used to treat attention-deficit hyperactivity disorder. MPH is currently the preferred substance among most intravenous (i.v.) substance users in Iceland. Four types of MPH preparations were available in Iceland at the time of study: Immediate-release (IR), sustained-release (SR), osmotic controlled-release oral delivery (OROS) tablet and osmotic-controlled release (OCR). MPH OROS has previously been rated the least desirable by i...
June 13, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28371725/age-related-pharmacotherapy-of-attention-deficit-hyperactivity-disorder-in-slovenia-in-children-and-adolescents-a-population-based-study
#7
M Stuhec, I Locatelli
BACKGROUND: There are no data on age-related pharmacotherapy for Attention Deficit Hyperactivity Disorder (ADHD) medication in children and adolescents in the most European countries. The main aim of this paper was to obtain that data for children and adolescents in Slovenia. METHOD: The number of ADHD drug prescriptions per patient was obtained from the health claims data on prescription drugs of the Health Insurance Institute of Slovenia for the study period (2003-2015)...
May 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28366111/safety-of-treatments-for-adhd-in-adults-pairwise-and-network-meta-analyses
#8
Danielly Chierrito de Oliveira, Patricia Guerrero de Sousa, Camila Borges Dos Reis, Fernanda Stumpf Tonin, Laiza Maria Steimbach, Suzane Virtuoso, Fernando Fernandez-Llimos, Roberto Pontarolo, Andréia Cristina Conegero Sanches
OBJECTIVE: The aim of the study was to analyze evidence comparing the profile of drugs used to treat ADHD in adult patients. METHOD: Systematic searches were conducted in electronic databases. Randomized, double-blind, parallel controlled trials that evaluated the safety of drugs in ADHD were included. The statistical analyses were conducted by pairwise meta-analyses and mixed treatment comparison (MTC). RESULTS: Ten ( n = 3006) trials were included in the analyses...
March 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28328695/effect-of-biperiden-treatment-in-acute-orofacial-and-extremity-dyskinesia-with-methylphenidate-therapy
#9
Elif Acar Arslan, Erhan Arslan, Anil Kilinç, Özkan Göksu
Methylphenidate is a stimulant drug commonly prescribed to individuals with attention-deficit/hyperactivity disorder. The suggested underlying mechanism of acute dyskinesias is dopaminergic transmission increase. We describe a 9-year-old boy with a diagnosis of attention-deficit/hyperactivity disorder admitted to emergency clinic with primarily orofacial and extremity dyskinesia after administration of a first dose of 18 mg OROS (osmotic [controlled] release oral) methylphenidate (Concerta). OROS methylphenidate was discontinued, and the patient's symptoms resolved within 20 minutes after injection of biperiden by intravenous route (0...
March 21, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28281767/the-effect-of-methylphenidate-oros-sup-%C3%A2-sup-on-the-narrative-ability-of-children-with-attention-deficit-hyperactivity-disorder
#10
Tessa L Rausch, Diane L Kendall, Sara T Kover, Elizabeth M Louw, Ursula L Zsilavecz, Anita Van der Merwe
BACKGROUND AND OBJECTIVE: Children with attention-deficit hyperactivity disorder (ADHD) experience difficulty with expressive language, including form (e.g. grammatical construction) and content (e.g. coherence). The current study aimed to investigate the effect of methylphenidate-Osmotic Release Oral System® (MPH-OROS®) on the narrative ability of children with ADHD and language impairment, through the analysis of microstructure and macrostructure narrative elements. METHOD: In a single group off-on medication test design, narratives were obtained from 12 children with ADHD, aged 7-13 years, using wordless picture books...
February 27, 2017: South African Journal of Communication Disorders. die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings
https://www.readbyqxmd.com/read/28280346/trend-characteristics-and-pharmacotherapy-of-adults-diagnosed-with-attention-deficit-hyperactivity-disorder-a-nationwide-survey-in-taiwan
#11
Yu-Shian Cheng, Yu-Chiau Shyu, Sheng-Yu Lee, Shin-Sheng Yuan, Chun-Ju Yang, Kang-Chung Yang, Tung-Liang Lee, Liang-Jen Wang
OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) in adults may result in functional impairment warranting clinical interventions. However, few studies have investigated the diagnosis and treatment rates of adult ADHD in non-Caucasian ethnic groups. This study used nationwide population-based data to investigate the rate of diagnosis, associated characteristics, and pharmacological treatment for adult ADHD in Taiwan. METHODS: Adults (age ≥18 years) newly diagnosed with ADHD (n=5,397) between January 2000 and December 2011 were enrolled from the National Health Insurance database in Taiwan...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27879551/no-superiority-of-treatment-with-osmotic-controlled-release-oral-delivery-system-methylphenidate-over-short-medium-acting-methylphenidate-preparations-in-the-rate-and-timing-of-injuries-in-children-with-attention-deficit-hyperactivity-disorder
#12
Pavel Golubchik, Arad Kodesh, Abraham Weizman
OBJECTIVES: Methylphenidate (MPH) treatment in patients with attention-deficit/hyperactivity disorder (ADHD) is reported to reduce the risk for injuries. In the present study, the rate and timing of injuries were compared among the various MPH preparations (4 and 6-8 vs 12 hour-acting) in children with ADHD. METHODS: This real-world retrospective study covered the years 2011 to 2013. Participants included 2042 youngsters (aged 4-18 years, 13.01 ± 3.2 years; 71...
January 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/27746700/effects-of-maternal-symptom-ratings-and-other-clinical-features-on-short-term-treatment-response-to-oros-methylphenidate-in-children-and-adolescents-with-adhd-in-a-naturalistic-clinical-setting
#13
Esra Cop Tasgin, Ozgur Oner, Pinar Yurtbasi, Kerim Munir
OBJECTIVE: To investigate the effect of Attention Deficit Hyperactivity Disorder (ADHD), antisocial behavior and anxiety/depression ratings of mothers, and child and adolescents' age, gender, ADHD subtype, and comorbidity on one-month drug treatment response to OROS methylphenidate in ADHD in a naturalistic setting. METHODS: The analyses included 223 subjects (191 boys, 32 girls; age 6-15 years, mean: 9.4) treated with OROS methylphenidate (18-72 mg/day, mean: 31 mg/d; 0...
2016: Bulletin of Clinical Psychopharmacology [Klinik Psikofarmakoloji Bülteni]
https://www.readbyqxmd.com/read/27536342/a-randomized-double-blind-cross-over-phase-iv-trial-of-oros-methylphenidate-concerta-%C3%A2-and-generic-novo-methylphenidate-er-c-novo-generic
#14
Angelo Fallu, Farida Dabouz, Melissa Furtado, Leena Anand, Martin A Katzman
OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral disorder with onset during childhood. Multiple aspects of a child's development are hindered, in both home and school settings, with negative impacts on social, emotional, and cognitive functioning. If left untreated, ADHD is commonly associated with poor academic achievement and low occupational status, as well as increased risk of substance abuse and delinquency. The objective of this study was to evaluate adult ADHD subject reported outcomes when switched from a stable dose of CONCERTA(®) to the same dose of generic Novo-methylphenidate ER-C(®)...
August 2016: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/27518196/initiation-and-persistence-of-pharmacotherapy-for-youths-with-attention-deficit-hyperactivity-disorder-in-taiwan
#15
Liang-Jen Wang, Kang-Chung Yang, Sheng-Yu Lee, Chun-Ju Yang, Ting-Shuo Huang, Tung-Liang Lee, Shin-Sheng Yuan, Yu-Chiau Shyu
BACKGROUND: Pharmacotherapy is an effective therapeutic option for attention deficit hyperactivity disorder (ADHD). Understanding the patterns of medication treatment is crucial for clinical practice. This study employed nationwide population-based data to elucidate the initiation and persistence of pharmacotherapy (immediate-release methylphenidate [IR-MPH], osmotic controlled-release formulations of methylphenidate [OROS-MPH] and atomoxetine [ATX]) for youths with ADHD in Taiwan. METHODS: Patients first receiving an ADHD diagnosis at age 18 or younger between January 2000 and December 2009 (n = 112,140; mean age at ADHD diagnosis: 7...
2016: PloS One
https://www.readbyqxmd.com/read/27487193/randomized-6-week-placebo-controlled-study-of-treatment-for-adult-attention-deficit-hyperactivity-disorder-individualized-dosing-of-osmotic-release-oral-system-oros-methylphenidate-with-a-goal-of-symptom-remission
#16
RANDOMIZED CONTROLLED TRIAL
David W Goodman, H Lynn Starr, Yi-Wen Ma, Anthony L Rostain, Steve Ascher, Robert B Armstrong
OBJECTIVE: To evaluate the efficacy and safety of individualized dosing within the approved dose range for osmotic-release oral system (OROS) methylphenidate hydrochloride in adults with attention-deficit/hyperactivity disorder (ADHD). METHODS: A double-blind, 6-week trial was conducted between July 2009 and February 2010 at 35 US sites. Adults with ADHD (DSM-IV diagnostic criteria) and a screening ADHD Investigator Symptom Rating Scale (AISRS) score > 24 were randomly assigned to OROS methylphenidate 18 mg or matching placebo...
January 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27478110/medication-persistence-duration-of-treatment-and-treatment-switching-patterns-among-canadian-patients-taking-once-daily-extended-release-methylphenidate-medications-for-attention-deficit-hyperactivity-disorder-a-population-based-retrospective-cohort-study
#17
Laura Park-Wyllie, Judy Van Stralen, Doron Almagor, Wendy Dobson-Belaire, Katia Charland, Andrew Smith, Jacques Le Lorier
PURPOSE: We conducted a retrospective cohort study to compare medication use patterns of a long-acting extended-release methylphenidate (Osmotic Release Oral System [OROS(®)] methylphenidate, CONCERTA(®)) and Teva-methylphenidate (methylphenidate ER-C), a generic drug determined by the Canadian regulatory authority, Health Canada, to be bioequivalent to OROS(®) methylphenidate. METHODS: We established an OROS(®) methylphenidate-experienced and new-user population cohort to compare medication use patterns, including medication persistence, duration of therapy, and treatment-switching patterns...
August 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27473346/is-emotion-recognition-the-only-problem-in-adhd-effects-of-pharmacotherapy-on-face-and-emotion-recognition-in-children-with-adhd
#18
RANDOMIZED CONTROLLED TRIAL
Esra Demirci, Ayten Erdogan
The objectives of this study were to evaluate both face and emotion recognition, to detect differences among attention deficit and hyperactivity disorder (ADHD) subgroups, to identify effects of the gender and to assess the effects of methylphenidate and atomoxetine treatment on both face and emotion recognition in patients with ADHD. The study sample consisted of 41 male, 29 female patients, 8-15 years of age, who were diagnosed as having combined type ADHD (N = 26), hyperactive/impulsive type ADHD (N = 21) or inattentive type ADHD (N = 23) but had not previously used any medication for ADHD and 35 male, 25 female healthy individuals...
December 2016: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/27390695/comparative-efficacy-of-methylphenidate-and-atomoxetine-in-the-treatment-of-attention-deficit-hyperactivity-disorder-in-children-and-adolescents-a-systematic-review-and-meta-analysis
#19
Golandam Rezaei, Seyed Alireza Hosseini, Ali Akbari Sari, Alireza Olyaeemanesh, Mohamad Hassan Lotfi, Mojtaba Yassini, Reza Bidaki, Bijan Nouri
BACKGROUND: The aim of this study was to directly compare efficacy of atomoxetine and methylphenidate in treatment of children and adolescents 6- 18 years. METHODS: All published, randomized, open label or double blind trials, comparing the efficacy of methylphenidate with atomoxetine in treatment of children diagnosed with ADHD, using DSM-IV criteria were included in this study; ADHD Rating Scale-IV-Parent Version: Investigator Administered and Scored (ADHDRS) scores was used...
2016: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/27005307/a-network-meta-analysis-of-atomoxetine-and-osmotic-release-oral-system-methylphenidate-in-the-treatment-of-attention-deficit-hyperactivity-disorder-in-adult-patients
#20
Chris Bushe, Kathleen Day, Victoria Reed, Kristina Karlsdotter, Lovisa Berggren, Ashley Pitcher, Foula Televantou, Virginia Haynes
The lack of head-to-head clinical studies powered to compare atomoxetine and osmotic release oral system (OROS) methylphenidate necessitates treatment comparison by methods that include indirect evidence such as network meta-analysis (NMA). A NMA assessing the relative treatment effects of atomoxetine and OROS methylphenidate in adults with attention-deficit/hyperactivity disorder (ADHD) was conducted. Studies were identified by systematic literature review. Analyses summarised improvements in efficacy, measured by ADHD-specific scales, using Cohen'sdto calculate the standardised mean difference (SMD), and all cause discontinuations...
May 2016: Journal of Psychopharmacology
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