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Ye Yuan, Judy Major-Girardin, Steven Brown
People utilize multiple expressive modalities for communicating narrative ideas about past events. The three major ones are speech, pantomime, and drawing. The current study used functional magnetic resonance imaging to identify common brain areas that mediate narrative communication across these three sensorimotor mechanisms. In the scanner, participants were presented with short narrative prompts akin to newspaper headlines (e.g., "Surgeon finds scissors inside of patient"). The task was to generate a representation of the event, either by describing it verbally through speech, by pantomiming it gesturally, or by drawing it on a tablet...
June 19, 2018: Journal of Cognitive Neuroscience
Akin Inderson, Marije Slingerland, Arantza Farina Sarasqueta, Wobbe O de Steur, Jurjen J Boonstra
No abstract text is available yet for this article.
May 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Samir Jaber, Catherine Paugam, Emmanuel Futier, Jean-Yves Lefrant, Sigismond Lasocki, Thomas Lescot, Julien Pottecher, Alexandre Demoule, Martine Ferrandière, Karim Asehnoune, Jean Dellamonica, Lionel Velly, Paër-Sélim Abback, Audrey de Jong, Vincent Brunot, Fouad Belafia, Antoine Roquilly, Gérald Chanques, Laurent Muller, Jean-Michel Constantin, Helena Bertet, Kada Klouche, Nicolas Molinari, Boris Jung
BACKGROUND: Acute acidaemia is frequently observed during critical illness. Sodium bicarbonate infusion for the treatment of severe metabolic acidaemia is a possible treatment option but remains controversial, as no studies to date have examined its effect on clinical outcomes. Therefore, we aimed to evaluate whether sodium bicarbonate infusion would improve these outcomes in critically ill patients. METHODS: We did a multicentre, open-label, randomised controlled, phase 3 trial...
June 14, 2018: Lancet
Alix Cooper
Over the past several decades, historians of science have come increasingly to focus on the role of so-called "paper technologies," reorganizing and transforming information through the use of paper and pen, in the emergence of modern science. Taking as a case study an effort by administrators in the seventeenth-century German princely state of Saxe-Gotha to enlist foresters and herb-women to catalog the medicinal plants of the territory, this article analyzes the varied forms of paperwork produced in the process, including an extremely unusual table, and argues that the table represented an effort to produce a synoptic visualization, akin to but not identical to a map, of the location of the territory's herbs...
June 1, 2018: History of Science; An Annual Review of Literature, Research and Teaching
S Ooms, B Nemeth, J J Wever, B Knippenberg, H van Overhagen, R G Statius van Eps
OBJECTIVES: Acute Kidney Injury (AKI) after open aortic repair is subject to multiple patient- and operation-related variables. Hostile neck morphology in open aneurysm repair is thought to contribute to this AKI risk post-operatively. The aim of this study was to evaluate if large neck atheroma is a possible risk factor in the postoperative development of AKI. METHODS: Retrospectively 137 patients were evaluated for neck atheroma and AKI incidence. Atheroma load measurements were performed by two different techniques...
June 14, 2018: Annals of Vascular Surgery
W K Coblentz, M S Akins, N M Esser, R K Ogden, S L Gelsinger
Various forms of overcrowding are common in heifer-rearing operations. Our objectives for this study were to evaluate the effects of overstocking at the feedbunk (100, 133, 160, or 200% of capacity) on the growth performance, feedbunk sorting behaviors, and hygiene of 128 gravid Holstein heifers (475 ± 55.3 kg) consuming an alfalfa haylage and corn silage diet diluted with processed wheat straw at an inclusion rate of 25.2% (DM basis). In this study, heifers were overstocked only at the feedbunk, and not with respect to available freestalls or pen area...
June 13, 2018: Journal of Dairy Science
Zhenjiang Bai, Fang Fang, Zhong Xu, Chunjiu Lu, Xueqin Wang, Jiao Chen, Jian Pan, Jian Wang, Yanhong Li
BACKGROUND: Fibroblast growth factor 23 (FGF23) and insulin-like growth factor binding protein 7 (IGFBP-7) are suggested to be biomarkers for predicting acute kidney injury (AKI). We compared them with proposed AKI biomarker of cystatin C (CysC), and aimed (1) to examine whether concentrations of these biomarkers vary with age, body weight, illness severity assessed by pediatric risk of mortality III score, and kidney function assessed by estimated glomerular filtration rate (eGFR), (2) to determine the association between these biomarkers and AKI, and (3) to evaluate whether these biomarkers could serve as early independent predictors of AKI in critically ill children...
June 15, 2018: BMC Pediatrics
F I Tade, W G Wiles, G Lu, B Bilir, O Akin-Akintayo, J S Lee, D Patil, W Yu, C Ormenisan Gherasim, B Fei, C S Moreno, A O Osunkoya, E J Teoh, S Oka, H Okudaira, M M Goodman, D M Schuster
We investigated if previously demonstrated inhibition of fluciclovine (18 F) in vitro could be replicated in a PC3-Luc xenograft mouse model. Following intratumoral injection of 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), alpha-(methylamino)isobutyric acid (MeAIB) or saline, fluciclovine PET tumor-to-background activity was 43.6 (± 5.4)% and 25.3 (± 5.2)% lower in BCH (n = 6) and MeAIB (n = 5) injected PC3 Luc xenografts, respectively, compared to saline-injected controls (n = 2)...
June 15, 2018: Amino Acids
Maya S Kummrow, Martin Brüne
  Despite the growing knowledge and literature on primate medicine, assessment and treatment of behavioral abnormalities in nonhuman primates (NHPs) is an underdeveloped field. There is ample evidence for similarity between humans and great apes, including basic neurologic physiology and emotional processes, and no substantial argument exists against a concept of continuity for abnormal conditions in NHPs that emerge in response to adverse experiences, akin to human psychopathology. NHPs have served as models for human psychopathologies for many decades, but the acquired knowledge has only hesitantly been applied to primates themselves...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Peter M Krafft
Researchers have recently demonstrated that group performance across tasks tends to be correlated, motivating the use of a single metric for the general collective intelligence of groups akin to general intelligence metrics for individuals. High general collective intelligence is achieved when a group performs well across a wide variety of tasks. A number of factors have been shown to be predictive of general collective intelligence, but there is sparse formal theory explaining the presence of correlations across tasks, betraying a fundamental gap in our understanding of what general collective intelligence is measuring...
June 13, 2018: Topics in Cognitive Science
Mete Akin, Osman Cagin Buldukoglu, Haydar Adanir, Inci Suleymanlar, Dinc Dincer, Bulent Yildirim
Objective: Successful treatment is possible with novel direct-acting oral antiviral agents in solid organ transplant patients with hepatitis C. In this study, the effectiveness and safety of sofosbuvir/ledipasvir ± ribavirin treatment in liver and/or renal transplant patients with chronic hepatitis C were evaluated. Materials and methods: A total of 23 liver and/or renal transplant patients who received sofosbuvir/ledipasvir ± ribavirin for chronic hepatitis C over 12 or 24 weeks were enrolled in the study...
2018: SAGE Open Medicine
P Kurpiers, P Magnard, T Walter, B Royer, M Pechal, J Heinsoo, Y Salathé, A Akin, S Storz, J-C Besse, S Gasparinetti, A Blais, A Wallraff
Sharing information coherently between nodes of a quantum network is fundamental to distributed quantum information processing. In this scheme, the computation is divided into subroutines and performed on several smaller quantum registers that are connected by classical and quantum channels 1 . A direct quantum channel, which connects nodes deterministically rather than probabilistically, achieves larger entanglement rates between nodes and is advantageous for distributed fault-tolerant quantum computation 2 ...
June 2018: Nature
Najah F Ghalyan, David J Miller, Asok Ray
Estimation of a generating partition is critical for symbolization of measurements from discrete-time dynamical systems, where a sequence of symbols from a (finite-cardinality) alphabet may uniquely specify the underlying time series. Such symbolization is useful for computing measures (e.g., Kolmogorov-Sinai entropy) to identify or characterize the (possibly unknown) dynamical system. It is also useful for time series classification and anomaly detection. The seminal work of Hirata, Judd, and Kilminster (2004) derives a novel objective function, akin to a clustering objective, that measures the discrepancy between a set of reconstruction values and the points from the time series...
June 12, 2018: Neural Computation
Sinead H McEvoy, Mitchell C Raeside, Joshua Chaim, Behfar Ehdaie, Oguz Akin
OBJECTIVE: MRI of the prostate is widely used in prostate cancer for local staging. The purpose of this article is to show how preoperative prostate MRI findings may be used as a road map for surgery to preserve the neurovascular bundle, identify risk factors associated with positive surgical margins, and evaluate findings associated with intraoperative complications and functional recovery after surgery. CONCLUSION: Knowledge of surgically relevant imaging findings can increase radiologists' confidence in reporting them to our colleagues...
June 12, 2018: AJR. American Journal of Roentgenology
Marialuisa Aufiero, Ryan Gilmour
The axioms of stereoelectronic theory constitute an atlas to navigate the contours of molecular space. All too rarely lauded, the advent and development of stereoelectronic theory has been one of organic chemistry's greatest triumphs. Inevitably, however, in the absence of a comprehensive treatise, many of the field's pioneers do not receive the veneration that they merit. Rather their legacies are the stereoelectronic pillars that persist in teaching and research. This ubiquity continues to afford practitioners of organic chemistry with an abundance of opportunities for creative endeavor in reaction design, in conceiving novel activation modes, in preorganizing intermediates, or in stabilizing productive transition states and products...
June 12, 2018: Accounts of Chemical Research
Ayse Feyda Nursal, Ercan Turkmen, Suheyla Uzun Kaya, Akin Tekcan, Ozlem Sezer, Sumeyya Deniz Celik, Serbulent Yigit
INTRODUCTION: The most important complication of familial Mediterranean fever (FMF) is secondary amyloidosis, which can lead to kidney failure. Genetic variability in the genes of various components of the renin-angiotensin system may play a role in the pathogenesis of the kidney disorders.  The aim of the present study was to investigate the association between angiotensin converting enzyme (ACE) gene I/D variant and risk of developing FMF-related amyloidosis in Turkish patients. MATERIALS AND METHODS: A total of 240 individuals consisting of 40 patients with FMF-related amyloidosis, 100 FMF patients without amyloidosis, and 100 healthy controls were recruited...
May 2018: Iranian Journal of Kidney Diseases
Jiangyu Yan, Sandro Holzer, Luca Pellegrini, Stephen D Bell
The cellular replicative DNA polymerases cannot initiate DNA synthesis without a priming 3' OH. During DNA replication, this is supplied in the context of a short RNA primer molecule synthesized by DNA primase. The primase of archaea and eukaryotes, despite having varying subunit compositions, share sequence and structural homology. Intriguingly, archaeal primase has been demonstrated to possess the ability to synthesize DNA de novo, a property shared with the eukaryotic PrimPol enzymes. The dual RNA and DNA synthetic capabilities of the archaeal DNA primase have led to the proposal that there may be a sequential hand-off between these synthetic modes of primase...
June 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
Shi-Min Yuan
Acute kidney injury (AKI) is a common complication of pediatric cardiac surgery and is associated with increased morbidity and mortality. Literature of AKI after pediatric cardiac surgery is comprehensively reviewed in terms of incidence, risk factors, biomarkers, treatment and prognosis. The novel RIFLE (pediatric RIFLE for pediatrics), Acute Kidney Injury Network (AKIN) and Kidney Disease Improving Global Outcomes (KDIGO) criteria have brought about unified diagnostic standards and comparable results for AKI after cardiac surgery...
March 30, 2018: Pediatrics and Neonatology
Skandarupan Jayaratnam, Sonia Kua, Caroline deCosta, Richard Franklin
BACKGROUND: Australia has a maternal mortality ratio of 6.8/100000 live births, a rate akin to other developed countries and consistent with the high level care provided within the Australian health care system. With maternal mortality at very low levels assessment of severe maternal morbidity is increasingly being used as an indicator of quality of care and to identify areas for improvement in maternity services. The WHO maternal 'near miss' criteria is a standardised tool has been increasingly used worldwide to assess maternal morbidity and standards of maternity care...
June 11, 2018: BMC Pregnancy and Childbirth
Tobias Becher, Jens Müller, Ibrahim Akin, Stefan Baumann, Katharina Bosch, Ksenija Stach, Martin Borggrefe, Bernd Pötzsch, Dirk Loßnitzer
PURPOSE: Septic shock is commonly associated with hemostatic abnormalities. The endothelium-activated serine protease activated protein C (APC) plays a pivotal role in limiting coagulation and possesses anti-apoptotic and anti-inflammatory properties. We hypothesized that APC levels correlate with established coagulation parameters and provide prognostic information in patients with septic shock. METHODS: We conducted a prospective, observational cohort study in patients with septic shock...
June 2, 2018: Journal of Critical Care
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