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https://www.readbyqxmd.com/read/29678542/effect-of-intravascular-contrast-agent-on-diffusion-and-perfusion-fraction-coefficients-in-the-peripheral-zone-and-prostate-cancer
#1
Yousef Mazaheri, Andreas M Hötker, Amita Shukla-Dave, Oguz Akin, Hedvig Hricak
PURPOSE: To determine whether water diffusion and the perfusion fraction coefficients in prostate peripheral zone (PZ) and prostate cancer (PCa) are affected by intravenous contrast injection and explore the potential mechanism behind previously reported differences between pre- and post-contrast ADC values. METHODS: Our institutional review board waived informed consent for this HIPAA-compliant, retrospective study, which included 32 patients (median age, 63 years; range, 47-77 years) with biopsy-proven, untreated PCa who underwent 3-Tesla MRI, including DW-MRI at b-values 0, 400, 700, 1000 s/mm2 before and after gadolinium injection...
April 17, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29677139/musculoskeletal-model-development-of-the-elbow-joint-with-an-experimental-evaluation
#2
Munsur Rahman, Mohsen Sharifi Renani, Akin Cil, Antonis P Stylianou
A dynamic musculoskeletal model of the elbow joint in which muscle, ligament, and articular surface contact forces are predicted concurrently would be an ideal tool for patient-specific preoperative planning, computer-aided surgery, and rehabilitation. Existing musculoskeletal elbow joint models have limited clinical applicability because of idealizing the elbow as a mechanical hinge joint or ignoring important soft tissue (e.g., cartilage) contributions. The purpose of this study was to develop a subject-specific anatomically correct musculoskeletal elbow joint model and evaluate it based on experimental kinematics and muscle electromyography measurements...
April 20, 2018: Bioengineering
https://www.readbyqxmd.com/read/29676909/-18-f-positron-emitting-trimethine-cyanine-fluorescent-contrast-for-image-guided-prostate-cancer-management
#3
Harikrishna Kommidi, Hua Guo, Fuad Nurili, Yogindra Vedvyas, Moonsoo M Jin, Timothy D McClure, Behfar Ehdaie, Haluk B Sayman, Oguz Akin, Omer Aras, Richard Ting
[18/19 F]-4, an anionic GCPII/PSMA inhibitor for image-guided intervention in prostate cancer, is described. [19 F]-4 is radiolabeled with a radiochemical yield that is ≥27% and a molar activity of 190 ± 50 mCi/μmol in a <1 h, one-step, aqueous isotopic exchange reaction. [19 F]-4 allows PSMA expression to be imaged by fluorescence (FL) and [18 F]-PET. PC3-PIP (PSMA-positive, EC50 = 6.74 ± 1.33 nM) cancers are specifically delineated in mice that bear 3 million (18 mg) PC3-PIP and PC3 (control, PSMA-negative) cells...
April 20, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29676403/combined-endoscopic-transorbital-and-endonasal-repair-of-high-flow-orbital-apex-middle-fossa-cerebrospinal-fluid-leak-with-a-nasoseptal-flap
#4
Brandon Lucke-Wold, Gustavo Mendez, David Cua, Paul Akins, Haley Gillham, Jeremy Ciporen
Background and importance: High flow orbital apex or middle fossa cerebrospinal fluid (CSF) leaks can be life threatening and complex to repair. These leaks associated with large dural defects are most commonly repaired with an open temporalis muscle patch or free flaps, but these flaps do not always stop the leak. Clinical Presentation: A 65-year-old patient presented two years after orbital exenteration and radiation for squamous cell carcinoma. He developed multi-organism meningitis and pneumocephalus secondary to a large high-flow orbital apex/middle fossa CSF leak...
2018: Journal of neuroinflammation and neurodegenerative diseases
https://www.readbyqxmd.com/read/29676023/estimating-the-variance-for-heterogeneity-in-arm-based-network-meta-analysis
#5
Hans-Peter Piepho, Laurence V Madden, James Roger, Roger Payne, Emlyn R Williams
Network meta-analysis can be implemented by using arm-based or contrast-based models. Here we focus on arm-based models and fit them using generalized linear mixed model procedures. Full maximum likelihood (ML) estimation leads to biased trial-by-treatment interaction variance estimates for heterogeneity. Thus, our objective is to investigate alternative approaches to variance estimation that reduce bias compared with full ML. Specifically, we use penalized quasi-likelihood/pseudo-likelihood and hierarchical (h) likelihood approaches...
April 19, 2018: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/29671040/preoperative-right-heart-hemodynamics-predict-postoperative-acute-kidney-injury-after-heart-transplantation
#6
Goksel Guven, Milos Brankovic, Alina A Constantinescu, Jasper J Brugts, Dennis A Hesselink, Sakir Akin, Ard Struijs, Ozcan Birim, Can Ince, Olivier C Manintveld, Kadir Caliskan
PURPOSE: Acute kidney injury (AKI) frequently occurs after heart transplantation (HTx), but its relation to preoperative right heart hemodynamic (RHH) parameters remains unknown. Therefore, we aimed to determine their predictive properties for postoperative AKI severity within 30 days after HTx. METHODS: From 1984 to 2016, all consecutive HTx recipients (n = 595) in our tertiary referral center were included and analyzed for the occurrence of postoperative AKI staged by the kidney disease improving global outcome criteria...
April 18, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29671022/-the-minimally-invasive-chevron-and-akin-osteotomy-mica
#7
REVIEW
Sebastian Altenberger, Stefanie Kriegelstein, Oliver Gottschalk, Florian Dreyer, Alexander Mehlhorn, Anke Röser, Markus Walther
OBJECTIVE: Percutaneous correction of a hallux valgus deformity with or without transfer metatarsalgia. INDICATIONS: Hallux valgus deformity up to 20° intermetatarsal angle, without instability of the first tarsometatarsal joint. CONTRAINDICATIONS: Symptomatic arthritis of the first metatarsophalangeal joint, as well as instability of the first tarsometatarsal joint. SURGICAL TECHNIQUE: Percutaneous performed osteotomy of the distal metatarsal 1 in combination with a medial closing wedge osteotomy of the proximal phalanx of the first toe...
April 18, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29669782/the-respiratory-environment-diverts-the-development-of-antiviral-memory-cd8-t-cells
#8
Hillary L Shane, Katie L Reagin, Kimberly D Klonowski
Our understanding of memory CD8+ T cells has been largely derived from acute, systemic infection models. However, memory CD8+ T cells generated from mucosal infection exhibit unique properties and, following respiratory infection, are not maintained in the lung long term. To better understand how infection route modifies memory differentiation, we compared murine CD8+ T cell responses to a vesicular stomatitis virus (VSV) challenge generated intranasally (i.n.) or i.v. The i.n. infection resulted in greater peak expansion of VSV-specific CD8+ T cells...
April 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29669659/perinatal-risk-factors-for-asthma-in-children-with-allergic-rhinitis-and-grass-pollen-sensitization
#9
S Tolga Yavuz, Stephanie Siebert, Onur Akin, Mutluay Arslan, Ersoy Civelek, Soyhan Bagci
BACKGROUND: Results of epidemiologic studies have determined several risk factors for asthma in school-age children. OBJECTIVE: To examine whether parental and perinatal risk factors, along with infantile feeding patterns, were associated with asthma in children with grass pollen allergy and allergic rhinitis. METHODS: We retrospectively analyzed the data of our cohort, which consisted of children with allergic rhinitis. Only children with grass pollen sensitization were enrolled...
May 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29669352/macrophage-migration-inhibitory-factor-173gc-variant-might-increase-the-risk-of-beh%C3%A3-et-s-disease
#10
Ayse Feyda Nursal, Serbulent Yigit, Ercan Tural, Goknur Kalkan, Mehmet Kemal Tumer, Akin Tekcan
OBJECTIVE: The aim of the present study was to investigate any possible association between macrophage migration inhibitory factor (MIF) -173GC variant and Behçet's Disease (BD) in a group of Turkish patients. SUBJECTS AND METHODS: In this case-control study performed in a university hospital, 111 patients with BD and 100 healthy age-matched controls participated. Genomic DNA was extracted from peripheral lymphocytes. MIF -173GC variant was genotyped using (PCR-RFLP)...
April 18, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29667927/biophysics-of-object-segmentation-in-a-collision-detecting-neuron
#11
Richard Burkett Dewell, Fabrizio Gabbiani
Collision avoidance is critical for survival, including in humans, and many species possess visual neurons exquisitely sensitive to objects approaching on a collision course. Here, we demonstrate that a collision-detecting neuron can detect the spatial coherence of a simulated impending object, thereby carrying out a computation akin to object segmentation critical for proper escape behavior. At the cellular level, object segmentation relies on a precise selection of the spatiotemporal pattern of synaptic inputs by dendritic membrane potential-activated channels...
April 18, 2018: ELife
https://www.readbyqxmd.com/read/29663282/the-frozen-brain-state-of-cryptococcus-gattii-a-globe-trotting-tropical-neurotropic-fungus
#12
Paul T Akins, Brian Jian
Initially reported in tropical regions, Cryptococcus gattii infection is now diagnosed globally. METHODS: case report; Literature review. Although initial reports described outbreaks of pulmonary and central nervous system (CNS) disease in tropical regions such as Australia and New Guinea, it is now clear that Cryptococcus gattii is a global, neurotropic pathogen. In contrast with C. neoformans, C. gattii patients are more likely to present with cryptococcomas in the brain and lungs and are often HIV negative...
April 16, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29662719/the-importance-of-uterosacral-ligament-anatomy-in-overactive-bladder-a-preliminary-study
#13
Cevdet Adıgüzel, Esra Selver Saygılı Yılmaz, Sefa Arlıer, Sevtap Seyfettinoğlu, Gökhan Söker, Gülsüm Uysal, Oğuz Yücel, Akın Sivaslıoğlu
Objective: To evaluate whether uterosacral ligament (USL) thickness measured using magnetic resonance imaging (MRI) was associated with overactive bladder (OAB) in otherwise healthy women. Materials and Methods: The study comprised 27 women with OAB and 27 healthy women (control group) who were followed up at the Obstetrics and Gynecology Department of a tertiary referral center. All subjects were evaluated using pelvic MRI to determine the transverse USL thickness...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29662540/the-impact-of-comorbidities-sex-and-age-on-the-occurrence-of-acute-kidney-injury-among-patients-undergoing-nephron-sparing-surgery
#14
Elias Hellou, Zaher Bahouth, Edmond Sabo, Zaid Abassi, Ofer Nativ
Background: The aim of this study was to report the impact of patients' baseline characteristics on the incidence of acute kidney injury (AKI) after nephron-sparing surgery (NSS) for localized kidney cancer. Patients and methods: Data from our kidney cancer database were retrospectively extracted to include 402 patients who underwent NSS between March 2000 and June 2016, and had sufficient data. Definition of AKI was based on the postoperative serum creatinine levels and estimated glomerular filtration rate (eGFR) magnitude, which were measured during the 72 h after surgery...
March 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29658353/early-initiation-of-zoledronic-acid-does-not-impact-bone-healing-or-clinical-outcomes-of-hallux-valgus-orthomorphia
#15
Lei Yang, Maowei Yang
Objective This prospective randomized controlled study was performed to determine whether early drug use for osteoporosis impacts bone healing after orthomorphic surgery for hallux valgus (HV) in menopausal patients with osteoporosis. Methods This study included 113 consecutive patients with osteoporosis who underwent a combination of Lapidus arthrodesis and Akin osteotomy for treatment of HV. The patients were randomly divided into a zoledronic acid (ZOL) group (5-mg intravenous injection of ZOL, n = 56) and a placebo group (n = 57); both ZOL and placebo were administered 1 week postoperatively...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29658148/biochemical-and-biomechanical-characterization-of-equine-cervical-facet-joint-cartilage
#16
S A O'Leary, J L White, J C Hu, K A Athanasiou
BACKGROUND: The equine cervical facet joint is a site of significant pathology. Located bilaterally on the dorsal spine, these diarthrodial joints work in conjunction with the intervertebral disc to facilitate appropriate spinal motion. Despite the high prevalence of pathology in this joint, the facet joint is understudied and thus lacking in viable treatment options. OBJECTIVE: The goal of this study was to characterise equine facet joint cartilage and provide a comprehensive database describing the morphological, histological, biochemical, and biomechanical properties of this tissue...
April 15, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29657303/sponge-long-non-coding-rnas-are-expressed-in-specific-cell-types-and-conserved-networks
#17
Federico Gaiti, William L Hatleberg, Miloš Tanurdžić, Bernard M Degnan
Although developmental regulation by long non-coding RNAs (lncRNAs) appears to be a widespread feature amongst animals, the origin and level of evolutionary conservation of this mode of regulation remain unclear. We have previously demonstrated that the sponge Amphimedon queenslandica -a morphologically-simple animal-developmentally expresses an array of lncRNAs in manner akin to more complex bilaterians (insects + vertebrates). Here, we first show that Amphimedon lncRNAs are expressed in specific cell types in larvae, juveniles and adults...
March 7, 2018: Non-Coding RNA
https://www.readbyqxmd.com/read/29650978/percutaneous-closure-of-left-atrial-appendage-significantly-affects-lipidome-metabolism
#18
G Yücel, M Behnes, C Barth, A Wenke, B Sartorius, K Mashayekhi, B Yazdani, T Bertsch, J Rusnak, A Saleh, U Hoffmann, C Fastner, S Lang, X Zhou, K Sattler, M Borggrefe, I Akin
Patients with non-valvular atrial fibrillation (AF) and a high risk for oral anticoagulation can be treated by percutaneous implantation of left atrial appendage occlusion devices (LAAC) to reduce the risk of cardio-embolic stroke. This study evaluates whether LAAC may influence lipid metabolism, which has never been investigated before. Patients with successful LAAC were included consecutively. Venous peripheral blood samples of patients were collected immediately before (T0, baseline) and 6 months after (T1, mid-term) LAAC...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29649586/nephrotoxicity-of-piperacillin-tazobactam-combined-with-vancomycin-should-it-be-a-concern
#19
Cafer Balcı, Ömrüm Uzun, Mustafa Arıcı, Sibel Aşçıoğlu Hayran, Deniz Yüce, Serhat Ünal
The combination of piperacillin-tazobactam (pip-tazo) and vancomycin provides a wide spectrum of activity against many pathogens acquired in the health-care setting. However, there have been reports of increased potential for nephrotoxicity with this combination. The aim of this study was to evaluate the nephrotoxic effect of pip-tazo plus vancomycin and compare it with that of pip-tazo and vancomycin alone, and meropenem plus vancomycin, another broad-spectrum combination. A total of 402 patients receiving either antimicrobial regimen for more than 48 hours were evaluated retrospectively in a two-year period...
April 9, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29648786/autonomous-thermal-oxidative-composition-inversion-and-texture-tuning-of-liquid-metal-surfaces
#20
Joel Cutinho, Boyce S Chang, Stephanie Oyola-Reynoso, Jiahao Chen, S Sabrina Akhter, Ian D Tevis, Nelson J Bello, Andrew Martin, Michelle C Foster, Martin M Thuo
Droplets capture an environment-dictated equilibrium state of a liquid material. Equilibrium, however, often necessitates nanoscale interface organization, especially with formation of a passivating layer. Herein, we demonstrate that this kinetics-driven organization may predispose a material to autonomous thermal-oxidative composition inversion (TOCI) and texture reconfiguration under felicitous choice of trigger. We exploit inherent structural complexity, differential reactivity, and metastability of the ultrathin (∼0...
April 16, 2018: ACS Nano
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