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https://www.readbyqxmd.com/read/29451341/validation-of-acute-kidney-injury-according-to-the-modified-kdigo-criteria-in-infants-after-cardiac-surgery-for-congenital-heart-disease
#1
Kentaro Ueno, Shunji Seki, Naohiro Shiokawa, Tomoyuki Matsuba, Akinori Miyazono, Daisuke Hazeki, Yutaka Imoto, Yoshifumi Kawano
AIM: We aimed to validate the incidence of, risk factors for, and postoperative outcomes of acute kidney injury (AKI) according to the modified Kidney Disease Improving Global Outcomes (m-KDIGO) criteria and compare this criteria with both the pediatric Risk, Injury, Failure, Loss, End-stage disease (pRIFLE) and Acute Kidney Injury Network (AKIN) criteria in infants after cardiac surgery. METHODS: We retrospectively enrolled 145 consecutive infants who underwent open-heart surgery at Kagoshima University Hospital...
February 16, 2018: Nephrology
https://www.readbyqxmd.com/read/29449312/prevalence-and-prognostic-impact-of-diabetes-in-takotsubo-syndrome-insights-from-the-international-multicenter-geist-registry
#2
Thomas Stiermaier, Francesco Santoro, Ibrahim El-Battrawy, Christian Möller, Tobias Graf, Giuseppina Novo, Andrea Santangelo, Enrica Mariano, Francesco Romeo, Pasquale Caldarola, Mario Fanelli, Holger Thiele, Natale Daniele Brunetti, Ibrahim Akin, Ingo Eitel
OBJECTIVE: In view of low prevalence rates, diabetes is discussed as a protective factor for the occurrence of Takotsubo syndrome (TTS). Furthermore, it was associated with improved outcome in a small single-center analysis. Therefore, this study assessed the prevalence and prognostic relevance of concomitant diabetes in TTS. RESEARCH DESIGN AND METHODS: A total of 826 patients with TTS were enrolled in an international, multicenter, registry-based study (eight centers in Italy and Germany)...
February 15, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29448393/localized-instabilities-and-spinodal-decomposition-in-driven-systems-in-the-presence-of-elasticity
#3
Esteban Meca, Andreas Münch, Barbara Wagner
We study numerically and analytically the instabilities associated with phase separation in a solid layer on which an external material flux is imposed. The first instability is localized within a boundary layer at the exposed free surface by a process akin to spinodal decomposition. In the limiting static case, when there is no material flux, the coherent spinodal decomposition is recovered. In the present problem, stability analysis of the time-dependent and nonuniform base states as well as numerical simulations of the full governing equations are used to establish the dependence of the wavelength and onset of the instability on parameter settings and its transient nature as the patterns eventually coarsen into a flat moving front...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29447939/the-cardiovascular-robustness-hypothesis-unmasking-young-adults-hidden-risk-for-premature-cardiovascular-death
#4
Lutz E Kraushaar, Alexander Dressel
An undetected high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factor levels is an acknowledged obstacle to CVD prevention. In this paper, we present the hypothesis that the vasculature's robustness against risk factor load will complement conventional risk factor models as a novel stratifier of risk. Figuratively speaking, mortality risk prediction without robustness scoring is akin to predicting the breaking risk of a lake's ice sheet considering load only while disregarding the sheet's bearing strength...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29446482/oncogenesis-as-a-selective-force-adaptive-evolution-in-the-face-of-a-transmissible-cancer
#5
REVIEW
Tracey Russell, Thomas Madsen, Frédéric Thomas, Nynke Raven, Rodrigo Hamede, Beata Ujvari
Similar to parasites, malignant cells exploit the host for energy, resources and protection, thereby impairing host health and fitness. Although cancer is widespread in the animal kingdom, its impact on life history traits and strategies have rarely been documented. Devil facial tumour disease (DFTD), a transmissible cancer, afflicting Tasmanian devils (Sarcophilus harrisii), provides an ideal model system to monitor the impact of cancer on host life-history, and to elucidate the evolutionary arms-race between malignant cells and their hosts...
February 15, 2018: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/29439517/hyperglycemia-alters-the-structure-and-hemodynamics-of-the-developing-embryonic-heart
#6
Taylor B Lawson, Devon E Scott-Drechsel, Venkat Keshav Chivukula, Sandra Rugonyi, Kent L Thornburg, Monica T Hinds
Congenital heart defects (CHDs) represent the most common form of human birth defects; approximately one-third of heart defects involve malformations of the outflow tract (OFT). Maternal diabetes increases the risk of CHD by 3-5 fold. During heart organogenesis, little is known about the effects of hyperglycemia on hemodynamics, which are critical to normal heart development. Heart development prior to septation in the chick embryo was studied under hyperglycemic conditions. Sustained hyperglycemic conditions were induced, raising the average plasma glucose concentration from 70 mg/dL to 180 mg/dL, akin to the fasting plasma glucose of a patient with diabetes...
February 12, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29438225/traits-associated-with-central-pain-augmentation-in-the-knee-pain-in-the-community-kpic-cohort
#7
Kehinde Akin-Akinyosoye, Nadia Frowd, Laura Marshall, Joanne Stocks, Gwen Fernandes, Ana Valdes, Daniel F McWilliams, Weiya Zhang, Michael Doherty, Eamonn Ferguson, David A Walsh
This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n=420) in the Knee Pain and related health In the Community (KPIC) baseline survey undertook pressure pain threshold (PPT) assessments. Items measuring specific traits related to central pain mechanisms were selected from the survey based on expert consensus, face validity, item association to underlying constructs measured by originating host questionnaires, adequate targeting and PPT correlations...
February 9, 2018: Pain
https://www.readbyqxmd.com/read/29432663/transcutaneous-bilirubinometry-should-be-carried-out-in-newborn-infants-at-least-seven-hours-after-phototherapy-finishes
#8
Agah Akin, S Umit Sarici, Murat Ozcan, Melis Akpinar, Demet Altun, Yuksel Yasartekin, Muhittin A Serdar, Dilek Sarici
Bilirubin rebound, which is a reincrease in serum bilirubin levels after the cessation of phototherapy, may develop due to variations in the rates of bilirubin production and clearance. The most commonly used method for testing bilirubin rebound is measuring total serum bilirubin (TSB) levels, because transcutaneous bilirubin (TcB) gives false negative results in newborn infants receiving phototherapy or when phototherapy has just finished. However, TcB is a more preferable method, because TSB is invasive and time consuming...
February 12, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29432392/response-to-letter-by
#9
Paul T Akins, Maria C S Inacio, Heather A Prentice, Kern H Guppy
No abstract text is available yet for this article.
February 9, 2018: Spine
https://www.readbyqxmd.com/read/29432353/practices-in-human-dignity-in-palliative-care-a-qualitative-study
#10
Esra Akin Korhan, Çağatay Üstün, Derya Uzelli Yilmaz
Respecting and valuing an individual's existential dignity forms the basis of nursing and medical practice and of nursing care. The objective of the study was to determine the approach to human dignity that nurses and physicians have while providing palliative care. This qualitative study was performed using a phenomenological research design. In-depth semistructured interviews were conducted in 9 nurses and 5 physicians with human dignity approach in palliative care. Following the qualitative Colaizzi method of analyzing the data, the statements made by the nurses and physicians during the interviews were grouped under 8 categories...
March 2018: Holistic Nursing Practice
https://www.readbyqxmd.com/read/29431748/effects-of-1-hexanol-on-c12e10-micelles-a-molecular-simulations-and-light-scattering-study
#11
Sampsa Vierros, Maria Sammalkorpi
The micelles of the non-ionic C12E10 surfactant and 1-hexanol as an aqueous solution additives are studied toward the purpose of understanding the role of alcohol additives in tuning the characteristics of alkyl-ethoxylate micellar systems. Our dynamic light scattering and cloud point experiments show that the addition of hexanol induces a response similar to an increase of temperature. We associate the change with increased attraction between the micelles at low to moderate hexanol loadings and a potential increase of the aggregate size at a high hexanol-to-surfactant ratio...
February 12, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29428737/the-uba-domain-of-snrk1-promotes-activation-and-maintains-catalytic-activity
#12
Shane Emanuelle, Monika S Doblin, Paul R Gooley, Matthew S Gentry
Sucrose non-fermenting 1-related protein kinase 1 (SnRK1) is a central metabolic regulator and the plant orthologue of the mammalian AMP-activated protein kinase (AMPK); both are energy-sensing heterotrimeric enzymes comprising a catalytic α- and regulatory β- and γ-subunits. α-Subunits contain a serine/threonine kinase domain (KD) at their N-terminus that is immediately followed by a small regulatory domain termed the auto-inhibitory domain (AID) in AMPK and the ubiquitin-associated domain (UBA) in SnRK1...
February 8, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29427966/do-higher-cut-off-values-for-tuberculin-skin-test-increase-the-specificity-and-diagnostic-agreement-with-interferon-gamma-release-assays-in-immunocompromised-bacillus-calmette-gu%C3%A3-rin-vaccinated-patients
#13
Serhat Erol, Fatma Arslan Ciftci, Aydin Ciledag, Akin Kaya, Ozlem Ozdemir Kumbasar
PURPOSE: Immunocompromised patients with latent tuberculosis infection (LTBI) are at high risk of progression to active tuberculosis. Detection and treatment of LTBI in this group of patients are very important to control active tuberculosis. Tuberculin skin test (TST) and interferon gamma release assays (IGRAs) are two methods for detection of LTBI. Diagnostic agreement between two tests are poor especially in Bacillus Calmette-Guérin (BCG) vaccinated immunocompromised patients. In this study, we tried to figure out if the use of a higher cut-off for TST increases diagnostic agreement with IGRAs and TST specificity and or not...
February 7, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29426943/giant-rhyolite-lava-dome-formation-after-7-3-ka-supereruption-at-kikai-caldera-sw-japan
#14
Yoshiyuki Tatsumi, Keiko Suzuki-Kamata, Tetsuo Matsuno, Hiroshi Ichihara, Nobukazu Seama, Koji Kiyosugi, Reina Nakaoka, Kazuo Nakahigashi, Hideaki Takizawa, Kazuki Hayashi, Tatsuro Chiba, Satoshi Shimizu, Mamoru Sano, Hikaru Iwamaru, Haruhisa Morozumi, Hiroko Sugioka, Yojiro Yamamoto
Kikai submarine caldera to the south of the Kyushu Island, SW Japan, collapsed at 7.3 ka during the latest supereruption (>500 km3 of magma) in the Japanese Archipelago. Multi functional research surveys of the T/S Fukae Maru in this caldera, including multi-beam echosounder mapping, remotely operated vehicle observation, multi-channel seismic reflection survey, and rock sampling by dredging and diving, provided lines of evidence for creation of a giant rhyolite lava dome (~32 km3) after the caldera collapse...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29426606/symptomatic-and-functional-recovery-from-major-depressive-disorder-in-the-ibadan-study-of-ageing
#15
Akin Ojagbemi, Taiwo Abiona, Zhehui Luo, Oye Gureje
OBJECTIVES: Very little is known about the association between symptomatic and functional recovery from late-life major depressive disorder (MDD) in sub-Saharan Africa. We investigated factors associated with sustained symptomatic remission (SR) from MDD and the 5-year trajectory of post-MDD physical functioning. DESIGN: 5-year prospective study with three follow-up waves in 2007, 2008, and 2009. SETTING/PARTICIPANTS: Household multistage probability sample of 2,149 Nigerians who were aged 65 years or older...
January 4, 2018: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29416269/transrectal-ultrasound-guided-prostate-rebiopsy-how-many-core-sampling-should-be-applied-to-which-patient
#16
Akın Soner Amasyalı, Uğur Yücetaş, Erkan Erkan, Murat Demiray, Emre Karabay, Cemalettin Murat, Gökhan Toktaş, Erdinç Ünlüer
Background: We investigated the correlation between the sampled number of cores in rebiopsy and the cancer detection rate (CDR). Materials and Methods: Two hundred and twelve patients with normal rectal examination who had undergone rebiopsy in the past 5 years were examined retrospectively. Moreover, 68% of them had undergone 12 cores (Group 1) while 32% had undergone 20 cores (Group 2). Both groups were compared with respect to the CDR. Results: There was no difference between groups in terms of age, total prostate-specific antigen, and prostate volume (P > 0...
January 2018: Urology Annals
https://www.readbyqxmd.com/read/29414920/interventional-left-atrial-appendage-closure-affects-the-metabolism-of-acylcarnitines
#17
Christian Fastner, Michael Behnes, Benjamin Sartorius, Annika Wenke, Siegfried Lang, Gökhan Yücel, Katherine Sattler, Jonas Rusnak, Ahmad Saleh, Christian Barth, Kambis Mashayekhi, Ursula Hoffmann, Martin Borggrefe, Ibrahim Akin
BACKGROUND: Left atrial appendage closure (LAAC) represents the interventional alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF). The metabolism of acylcarnitines was shown to affect cardiovascular diseases. This study evaluates the influence of successful LAAC on the metabolism of acylcarnitines. METHODS: Patients undergoing successful LAAC were enrolled prospectively. Peripheral blood samples for metabolomics measurements were collected immediately before (i...
February 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29411448/host-associated-bacterial-community-succession-during-amphibian-development
#18
Tiffany L Prest, Abigail K Kimball, Jordan G Kueneman, Valerie J McKenzie
Amphibians undergo significant developmental changes during their life cycle, as they typically move from a primarily aquatic environment to a more terrestrial one. Amphibian skin is a mucosal tissue that assembles communities of symbiotic microbiota. However, it is currently not well understood as to where amphibians acquire their skin symbionts, and whether the sources of microbial symbionts change throughout development. In this study, we utilized data collected from four wild boreal toad populations (Anaxyrus boreas); specifically, we sampled the skin bacterial communities during toad development, including eggs, tadpoles, subadults, and adults as well as environmental sources of bacteria (water, aquatic sediment, and soil)...
February 7, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29409298/use-of-a-percutaneous-osteotomy-with-plate-fixation-in-hallux-valgus-correction
#19
Rodrigo Díaz Fernández
BACKGROUND: With hundreds of operative methods described for correction of hallux valgus we can state that the ideal surgical treatment is still controversial. The Bösch technique has been used as a percutaneous way of correcting hallux valgus deformities with the use of a pin fixation. The aim of this study is to evaluate a new method of fixation by using a percutaneous locking plate. METHODS: Between June 2013 and January 2015, 24 consecutive percutaneous subcapital osteotomies of the first metatarsal bone were performed for the treatment of painful hallux valgus deformities in 24 patients...
September 20, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29409293/two-year-outcomes-of-minimally-invasive-hallux-valgus-surgery
#20
Chloe Xiaoyun Chan, Jonathan Zhi-Wei Gan, Hwei Chi Chong, Inderjeet Rikhraj Singh, Sean Yung Chuan Ng, Kevin Koo
BACKGROUND: We report our experience with the Minimally Invasive Chevron Akin (MICA) technique for correcting hallux valgus, and evaluate its effectiveness and associated complications. METHODS: Case series of 13 feet with mild to moderate symptomatic hallux valgus treated surgically from July 2013 to December 2014, with at least 48-months follow-up. Patients were assessed pre-operatively and post-operatively with radiographical measurements (Hallux Valgus Angle (HVA) and Intermetatarsal Angle (IMA)) and clinical scores (American Orthopaedic Foot and Ankle Society (AOFAS), 36-Item Short Form Health Survery (SF-36), Visual Analog Scale (VAS))...
October 13, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
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