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https://www.readbyqxmd.com/read/29161770/twin-models-of-environmental-and-genetic-influences-on-pubertal-development-salivary-testosterone-and-estradiol-in-adolescence
#1
Andrew D Grotzinger, Frank D Mann, Megan W Patterson, Kathrin Herzhoff, Jennifer L Tackett, Elliot M Tucker-Drob, K Paige Harden
OBJECTIVE: Research on sources of variation in adolescent's gonadal hormone levels is limited. We sought to decompose individual differences in adolescent testosterone, estradiol and pubertal status, into genetic and environmental components. DESIGN: A sample of male and female adolescent twins from the greater Austin and Houston areas provided salivary samples, with a subset of participants providing longitudinal data at two waves. PARTICIPANTS: The sample included 902 adolescent twins, 49% female, ages 13-20 years (M = 15...
November 21, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29160862/time-resolved-photoluminescence-microscopy-for-the-analysis-of-semiconductor-based-paint-layers
#2
Daniela Comelli, Alessia Artesani, Austin Nevin, Sara Mosca, Victor Gonzalez, Myriam Eveno, Gianluca Valentini
In conservation, science semiconductors occur as the constituent matter of the so-called semiconductor pigments, produced following the Industrial Revolution and extensively used by modern painters. With recent research highlighting the occurrence of various degradation phenomena in semiconductor paints, it is clear that their detection by conventional optical fluorescence imaging and microscopy is limited by the complexity of historical painting materials. Here, we illustrate and prove the capabilities of time-resolved photoluminescence (TRPL) microscopy, equipped with both spectral and lifetime sensitivity at timescales ranging from nanoseconds to hundreds of microseconds, for the analysis of cross-sections of paint layers made of luminescent semiconductor pigments...
November 21, 2017: Materials
https://www.readbyqxmd.com/read/29160180/incidental-findings-on-fdg-pet-ct-in-head-and-neck-cancer
#3
Christopher J Britt, Austin M Maas, Tabassum A Kennedy, Gregory K Hartig
Objective 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG PET/CT) imaging is common in head and neck cancer and often identifies incidental findings that necessitate additional patient evaluations. Our goal was to assess the frequency and nature of these incidental imaging findings on FDG-PET/CT. Study Design Retrospective cohort study. Setting Tertiary medical center. Subjects and Methods All patients with head and neck cancer who had undergone FDG-PET/CT imaging between January 2014 and June 2015 at our institution were evaluated for incidental findings...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29160065/transformation-of-the-anticancer-drug-doxorubicin-in-the-human-gut-microbiome
#4
Austin Yan, Elizabeth Culp, Julie Perry, Jennifer Lau, Lesley MacNeil, Michael G Surette, Gerard D Wright
Bacteria living in the human gut are implicated in the etiology of several diseases. Moreover, dozens of drugs are metabolized by elements of the gut microbiome, which may have further implications for human health. Here we screened a collection of primary gut isolates for their ability to inactivate the widely used antineoplastic drug doxorubicin and identified a strain of Raoultella planticola as a potent inactivator under anaerobic conditions. We demonstrate that R. planticola deglycosylates doxorubicin to metabolites 7-deoxydoxorubicinol and 7-deoxydoxorubicinolone via a reductive deglycosylation mechanism...
November 21, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29159836/mechanisms-of-calcium-sequestration-by-isolated-malpighian-tubules-of-the-house-cricket-acheta-domesticus
#5
Austin Browne, Michael J O'Donnell
Hemolymph calcium homeostasis in insects is achieved by the Malpighian tubules, primarily by sequestering excess Ca(2+) within internal calcium stores (Ca-rich granules) most often located within type I (principal) tubule cells. Using both the scanning ion-selective electrode technique and the Ramsay secretion assay this study provides the first measurements of basolateral and transepithelial Ca(2+) fluxes across the Malpighian tubules of an Orthopteran insect, the house cricket Acheta domesticus. Ca(2+) transport was specific to midtubule segments, where 97% of the Ca(2+) entering the tubule is sequestered within intracellular calcium stores and the remaining 3% is secreted into the lumen...
November 21, 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/29158551/the-international-rare-diseases-research-consortium-policies-and-guidelines-to-maximize-impact
#6
Hanns Lochmüller, Josep Torrent I Farnell, Yann Le Cam, Anneliene H Jonker, Lilian Pl Lau, Gareth Baynam, Petra Kaufmann, Hugh Js Dawkins, Paul Lasko, Christopher P Austin, Kym M Boycott
The International Rare Diseases Research Consortium (IRDiRC) has agreed on IRDiRC Policies and Guidelines, following extensive deliberations and discussions in 2012 and 2013, as a first step towards improving coordination of research efforts worldwide. The 25 funding members and 3 patient umbrella organizations (as of early 2013) of IRDiRC, a consortium of research funders that focuses on improving diagnosis and therapy for rare disease patients, agreed in Dublin, Ireland in April 2013 on the Policies and Guidelines that emphasize collaboration in rare disease research, the involvement of patients and their representatives in all relevant aspects of research, as well as the sharing of data and resources...
November 20, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29158473/notch1-is-a-mechanosensor-in-adult-arteries
#7
Julia J Mack, Thiago S Mosqueiro, Brian J Archer, William M Jones, Hannah Sunshine, Guido C Faas, Anais Briot, Raquel L Aragón, Trent Su, Milagros C Romay, Austin I McDonald, Cheng-Hsiang Kuo, Carlos O Lizama, Timothy F Lane, Ann C Zovein, Yun Fang, Elizabeth J Tarling, Thomas Q de Aguiar Vallim, Mohamad Navab, Alan M Fogelman, Louis S Bouchard, M Luisa Iruela-Arispe
Endothelial cells transduce mechanical forces from blood flow into intracellular signals required for vascular homeostasis. Here we show that endothelial NOTCH1 is responsive to shear stress, and is necessary for the maintenance of junctional integrity, cell elongation, and suppression of proliferation, phenotypes induced by laminar shear stress. NOTCH1 receptor localizes downstream of flow and canonical NOTCH signaling scales with the magnitude of fluid shear stress. Reduction of NOTCH1 destabilizes cellular junctions and triggers endothelial proliferation...
November 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/29157883/as-the-guard-changed-so-it-changes
#8
EDITORIAL
Austin Leahy
No abstract text is available yet for this article.
December 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29157626/risk-association-of-congenital-anomalies-in-patients-with-ambiguous-genitalia-a-22-year-single-center-experience
#9
Jennifer M Heeley, Abby S Hollander, Paul F Austin, Diane F Merritt, Victoria G Wesevich, Ina E Amarillo
BACKGROUND: Ambiguous genitalia refers to a form of differences of sex development (DSD) wherein the appearance of the external genitalia is atypical. This rare condition presents challenges in decision-making and clinical management. Review of historical data may reveal areas for clinical research to improve care for patients with ambiguous genitalia. OBJECTIVE: This chart review was performed to identify patients with ambiguous genitalia, and to classify them as having 46,XX DSD, 46,XY DSD, or sex chromosome DSD...
November 17, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29156833/targeting-aggressive-prostate-cancer-associated-cd44v6-using-phage-display-selected-peptides
#10
Ying Peng, Austin R Prater, Susan L Deutscher
There is a crucial need to identify new biomarkers associated with aggressive prostate cancer (PCa) including those associated with cancer stem cells (CSCs). CD44v6, generated by alternative splicing of CD44, has been proposed as a CSC biomarker due to its correlation with aggressive PCa disease. We hypothesized that phage display selected peptides that target CD44v6 may serve as theranostic agents for aggressive PCa. Here, a 15 amino acid peptide ("PFT") was identified by affinity selection against a peptide derived from the v6 region of CD44v6...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154270/ubisol-q10-a-nanomicellar-water-soluble-formulation-of-coq10-treatment-inhibits-alzheimer-type-behavioral-and-pathological-symptoms-in-a-double-transgenic%C3%A2-mouse%C3%A2-tgapeswe-%C3%A2-psen1de9-model-of-alzheimer-s-disease
#11
Krithika Muthukumaran, Annie Kanwar, Caleb Vegh, Alexandra Marginean, Austin Elliott, Nicholas Guilbeault, Alexander Badour, Marianna Sikorska, Jerome Cohen, Siyaram Pandey
 Alzheimer's disease (AD) is one of the most common neurodegenerative pathologies for which there are no effective therapies to halt disease progression. Given the increase in the incidence of this disorder, there is an urgent need for pharmacological intervention. Unfortunately, recent clinical trials produced disappointing results. Molecular mechanisms of AD are converging on the notion that mitochondrial dysfunction, oxidative stress, and accumulation of dysfunctional proteins are involved in AD pathology...
November 16, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29153477/biomechanical-adaptations-during-running-differ-based-on-type-of-exercise-and-fitness-level
#12
Lindsay V Slater, Austin S Simpson, Silvia S Blemker, Jay Hertel, Susan A Saliba, Arthur L Weltman, Joseph M Hart
Lower extremity injuries are most common in more active and fit individuals, suggesting that adaptations from neuromuscular fatigue may differ depending on type of exercise and fitness level. The purpose of this study was to compare changes in gait in highly fit and recreationally active individuals before and after two exercise protocols. Lower extremity kinematics and kinetics were measured on the dominant leg during running before and after two exercise protocols (walking/sport) from 0 to 100% of gait in 24 healthy individuals divided into higher (n=13) and lower fitness (n=11) groups...
November 13, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29152995/endorsement-of-social-and-personal-values-predicts-the-desirability-of-men-and-women-as-long-term-partners
#13
Guilherme S Lopes, Nicole Barbaro, Yael Sela, Austin J Jeffery, Michael N Pham, Todd K Shackelford, Virgil Zeigler-Hill
A prospective romantic partner's desirability as a long-term partner may be affected by the values that he or she endorses. However, few studies have examined the effects of "values" on a person's desirability as a long-term partner. We hypothesized that individuals who endorse social values (vs. personal values) will be perceived as more desirable long-term partners (Hypothesis 1) and that the endorsement of social values will be especially desirable in a male (vs. female) long-term partner (Hypothesis 2)...
October 2017: Evolutionary Psychology: An International Journal of Evolutionary Approaches to Psychology and Behavior
https://www.readbyqxmd.com/read/29151367/surveillance-of-the-armed-forces-as-a-sentinel-system-for-detecting-adverse-effects-of-dietary-supplements-in-the-general-population
#14
Harris R Lieberman, Krista G Austin, Emily K Farina
OBJECTIVE: Half the US population takes dietary supplements, but surveillance systems available to regulatory and public health authorities to determine whether specific dietary supplements present a risk are inadequate and numerous severe injuries and deaths have occurred from their consumption. Uniformed military personnel regularly use dietary supplements and are more likely to use potentially dangerous supplements than civilians. Recently, the supplement 1,3-dimethylamylamine (DMAA) was marketed for physical performance-enhancement and weight loss...
November 20, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29146842/genome-sequences-of-19-novel-erwinia-amylovora-bacteriophages
#15
Ian N D Esplin, Jordan A Berg, Ruchira Sharma, Robert C Allen, Daniel K Arens, Cody R Ashcroft, Shannon R Bairett, Nolan J Beatty, Madeline Bickmore, Travis J Bloomfield, T Scott Brady, Rachel N Bybee, John L Carter, Minsey C Choi, Steven Duncan, Christopher P Fajardo, Brayden B Foy, David A Fuhriman, Paul D Gibby, Savannah E Grossarth, Kala Harbaugh, Natalie Harris, Jared A Hilton, Emily Hurst, Jonathan R Hyde, Kayleigh Ingersoll, Caitlin M Jacobson, Brady D James, Todd M Jarvis, Daniella Jaen-Anieves, Garrett L Jensen, Bradley K Knabe, Jared L Kruger, Bryan D Merrill, Jenny A Pape, Ashley M Payne Anderson, David E Payne, Malia D Peck, Samuel V Pollock, Micah J Putnam, Ethan K Ransom, Devin B Ririe, David M Robinson, Spencer L Rogers, Kerri A Russell, Jonathan E Schoenhals, Christopher A Shurtleff, Austin R Simister, Hunter G Smith, Michael B Stephenson, Lyndsay A Staley, Jason M Stettler, Mallorie L Stratton, Olivia B Tateoka, P J Tatlow, Alexander S Taylor, Suzanne E Thompson, Michelle H Townsend, Trever L Thurgood, Brittian K Usher, Kiara V Whitley, Andrew T Ward, Megan E H Ward, Charles J Webb, Trevor M Wienclaw, Taryn L Williamson, Michael J Wells, Cole K Wright, Donald P Breakwell, Sandra Hope, Julianne H Grose
Erwinia amylovora is the causal agent of fire blight, a devastating disease affecting some plants of the Rosaceae family. We isolated bacteriophages from samples collected from infected apple and pear trees along the Wasatch Front in Utah. We announce 19 high-quality complete genome sequences of E. amylovora bacteriophages.
November 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29141612/individual-level-and-community-level-determinants-of-cervical-cancer-screening-among-kenyan-women-a-multilevel-analysis-of-a-nationwide-survey
#16
Fentanesh Nibret Tiruneh, Kun-Yang Chuang, Peter Austin Morton Ntenda, Ying-Chih Chuang
BACKGROUND: Studies on the determinants of cervical cancer screening in sub-Saharan Africa have focused mostly on individual-level characteristics of cervical cancer screening. Therefore, in this study, we included both individual- and community-level indicators to examine the determinants of cervical cancer screening among Kenyan women. METHODS: We analyzed data from the 2014 Kenya Demographic and Health Surveys. Our analysis focused on 9016 married women of reproductive age (15-49 years)...
November 15, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29141457/disparities-associated-with-inpatient-palliative-care-utilization-by-patients-with-metastatic-gynecologic-cancers-a-study-of-3337-women
#17
Emily B Rosenfeld, John K Chan, Austin B Gardner, Natasha Curry, Lejla Delic, Daniel S Kapp
OBJECTIVE: To determine the factors associated with inpatient palliative care (PC) use in patients with metastatic gynecologic cancer. METHODS: Data were obtained from the Nationwide Inpatient Sample (NIS) for patients with metastatic cervical, uterine, and ovarian cancers. Chi-square and multivariate models were used for statistical analyses. RESULTS: Of 67 947 inpatients with metastatic gynecologic cancer, 3337 (5%) utilized PC (median age: 63 years, range: 18-102 years)...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29140950/development-of-clinical-process-measures-for-pediatric-burn-care-understanding-variation-in-practice-patterns
#18
Lewis E Kazis, Robert L Sheridan, Gabriel D Shapiro, Austin F Lee, Matthew H Liang, Colleen M Ryan, Jeffrey C Schneider, Martha Lydon, Marina Soley-Bori, Lily A Sonis, Emily C Dore, Tina Palmieri, David Herndon, Walter Meyer, Petra Warner, Richard Kagan, Frederick J Stoddard, Michael Murphy, Ronald G Tompkins
BACKGROUND: There has been little systematic examination of variation in pediatric burn care clinical practices and its effect on outcomes. As a first step, current clinical care processes need to be operationally defined. The highly specialized burn care units of the Shriners Hospitals for Children system present an opportunity to describe the processes of care. The aim of this study was to develop a set of process-based measures for pediatric burn care and examine adherence to them by providers in a cohort of pediatric burn patients...
November 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29139564/incident-diuretic-drug-use-and-adverse-respiratory-events-among-older-adults-with-copd
#19
Nicholas T Vozoris, Xuesong Wang, Peter C Austin, Denis E O'Donnell, Shawn D Aaron, Teresa M To, Andrea S Gershon
AIMS: Diuretic drugs may theoretically improve respiratory health outcomes in COPD through several possible mechanisms, but they might also lead to respiratory harm. We evaluated the association of incident oral diuretic drug use with respiratory-related morbidity and mortality among older adults with COPD. METHODS: This was a population-based, retrospective cohort study using health administrative data from Ontario, Canada, for the period 2008-2013. We identified adults aged 66 years and older with non-palliative COPD using a validated algorithm...
November 15, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29138301/genomic-variation-and-evolution-of-vibrio-parahaemolyticus-st36-over-the-course-of-a-transcontinental-epidemic-expansion
#20
Jaime Martinez-Urtaza, Ronny van Aerle, Michel Abanto, Julie Haendiges, Robert A Myers, Joaquin Trinanes, Craig Baker-Austin, Narjol Gonzalez-Escalona
Vibrio parahaemolyticus is the leading cause of seafood-related infections with illnesses undergoing a geographic expansion. In this process of expansion, the most fundamental change has been the transition from infections caused by local strains to the surge of pandemic clonal types. Pandemic clone sequence type 3 (ST3) was the only example of transcontinental spreading until 2012, when ST36 was detected outside the region where it is endemic in the U.S. Pacific Northwest causing infections along the U.S. northeast coast and Spain...
November 14, 2017: MBio
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