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https://www.readbyqxmd.com/read/29784967/the-cardiometabolic-burden-of-self-perceived-obesity-a-multilevel-analysis-of-a-nationally-representative-sample-of-korean-adults
#1
Yongjoo Kim, S Bryn Austin, S V Subramanian, Ichiro Kawachi
Emerging evidence has shown that self-perception of overweight/obese status is associated with unfavorable cardiometabolic outcomes, above and beyond actual body weight. Given the lack of research among Asian populations, we examined the association between weight perception and metabolic syndrome (MetS) and cardiometabolic risks among Koreans. Data from the 2010-2015 Korea National Health and Nutrition Examination Survey, including women (N = 12,181) and men (N = 9,448) aged 19-65 years, were analyzed...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784508/il-33-mast-cell-axis-is-central-in-ll-37-induced-bladder-inflammation-and-pain-in-a-murine-interstitial-cystitis-model
#2
M Martin Jensen, Wanjian Jia, Austin J Schults, Xiangyang Ye, Glenn D Prestwich, Siam Oottamasathien
Interstitial cystitis (IC), also known as painful bladder syndrome (PBS), is a debilitating chronic condition that afflicts over 3 million women above the age of 18 in the U.S., and most patients fail to respond to current treatment options. Mast cells have previously been implicated as both a diagnostic and prognostic marker in IC/PBS. Patients with IC/PBS have been shown to have elevated levels of IL-33, a cytokine released in response to tissue insult, in their urine. We hypothesize that mast cell-mediated inflammation induced from IL-33 may play an important role in initiating pain and inflammation in IC/PBS...
May 18, 2018: Cytokine
https://www.readbyqxmd.com/read/29784014/unintentional-sulfonylurea-toxicity-due-to-a-drug-drug-interaction-a-case-report
#3
Keith Gunaratne, Emily Austin, Peter E Wu
BACKGROUND: Sulfonylureas are widely used for type 2 diabetes mellitus, but these medications carry a risk of hypoglycemia. Drug-drug interactions that inhibit sulfonylurea metabolism and thus increase systemic exposure can cause unintentional sulfonylurea toxicity. CASE PRESENTATION: A 56-year-old man presented with severe, recurrent hypoglycemia. He had a history of type 2 diabetes mellitus and was taking the sulfonylurea gliclazide with no prior episodes of hypoglycemia...
May 21, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29782225/a-comparison-of-reproductive-and-energetic-states-in-a-marine-apex-predator-the-tiger-shark-galeocerdo-cuvier
#4
Neil Hammerschlag, Rachel A Skubel, James Sulikowski, Duncan J Irschick, Austin J Gallagher
To fuel the high energetic demands of reproduction, vertebrates employ different tactics of resource use. Large sharks exhibit long gestation periods and have relatively few well-developed young, which likely incurs high energetic costs. However, information on the relationship between the reproductive and energetic states for most shark species is lacking. In the present study, we used a noninvasive approach to assess relationships among reproductive stage, plasma triglyceride levels, body condition, and circulating reproductive hormones in free-ranging female tiger sharks (Galeocerdo cuvier)...
July 2018: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/29780869/cross-sectional-and-longitudinal-atrophy-is-preferentially-associated-with-tau-rather-than-amyloid-%C3%AE-positron-emission-tomography-pathology
#5
Brian A Gordon, Austin McCullough, Shruti Mishra, Tyler M Blazey, Yi Su, John Christensen, Aylin Dincer, Kelley Jackson, Russ C Hornbeck, John C Morris, Beau M Ances, Tammie L S Benzinger
Introduction: Structural magnetic resonance imaging is a marker of gray matter health and decline that is sensitive to impaired cognition and Alzheimer's disease pathology. Prior work has shown that both amyloid β (Aβ) and tau biomarkers are related to cortical thinning, but it is unclear what unique influences they have on the brain. Methods: Aβ pathology was measured with [18 F] AV-45 (florbetapir) positron emission tomography (PET) and tau was assessed with [18 F] AV-1451 (flortaucipir) PET in a population of 178 older adults, of which 123 had longitudinal magnetic resonance imaging assessments (average of 5...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29779472/effect-of-body-weight-on-metabolic-hormones-and-fatty-acid-metabolism-in-follicular-fluid-of-women-undergoing-in-vitro-fertilization-a-pilot-study
#6
Laurice Bou Nemer, Haolin Shi, Bruce Richard Carr, Ruth Ann Word, Orhan Bukulmez
INTRODUCTION: Obesity is an epidemic affecting more than one-third of adults in the United States. Obese women experience decreased fertility, explained in part by oocyte quality. Since follicular fluid (FF) provides an important microenvironment for oocyte growth, we sought to evaluate the effect of increased body weight on FF levels of 11 metabolic hormones and fatty acid metabolism. METHODS: The FF was collected from 25 women (10 normal weight, 10 overweight, and 5 obese) with diminished ovarian reserve undergoing in vitro fertilization (IVF) following a minimal stimulation protocol...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29778098/hydrochlorothiazide-and-risk-of-hearing-disorder-a-case-series
#7
Natnael Belai, Selamawit Gebrehiwet, Yodit Fitsum, Mulugeta Russom
BACKGROUND: Hydrochlorothiazide is not known to cause hearing disorder. The Eritrean Pharmacovigilance Centre, however, has received cases of hearing disorder, including irreversible deafness, associated with hydrochlorothiazide. The aim of this study is, therefore, to assess the causal relationship between hydrochlorothiazide and hearing disorder. METHODS: Data was retrieved from the WHO global adverse drug reaction database, VigiBase™. A search on VigiBase™ was made on August 6, 2017 using "hydrochlorothiazide" as drug substance, and "ototoxicity", "decreased hearing", and "vestibular disorder" as reaction terms...
May 20, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29777152/temporary-microglia-depletion-after-cosmic-radiation-modifies-phagocytic-activity-and-prevents-cognitive-deficits
#8
Karen Krukowski, Xi Feng, Maria Serena Paladini, Austin Chou, Kristen Sacramento, Katherine Grue, Lara-Kirstie Riparip, Tamako Jones, Mary Campbell-Beachler, Gregory Nelson, Susanna Rosi
Microglia are the main immune component in the brain that can regulate neuronal health and synapse function. Exposure to cosmic radiation can cause long-term cognitive impairments in rodent models thereby presenting potential obstacles for astronauts engaged in deep space travel. The mechanism/s for how cosmic radiation induces cognitive deficits are currently unknown. We find that temporary microglia depletion, one week after cosmic radiation, prevents the development of long-term memory deficits. Gene array profiling reveals that acute microglia depletion alters the late neuroinflammatory response to cosmic radiation...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29774232/multiple-origins-of-green-blood-in-new-guinea-lizards
#9
Zachary B Rodriguez, Susan L Perkins, Christopher C Austin
Several species of lizards from the megadiverse island of New Guinea have evolved green blood. An unusually high concentration of the green bile pigment biliverdin in the circulatory system of these lizards makes the blood, muscles, bones, tongue, and mucosal tissues bright green in color, eclipsing the crimson color from their red blood cells. This is a remarkable physiological feature because bile pigments are toxic physiological waste products of red blood cell catabolism and, when chronically elevated, cause jaundice in humans and all other vertebrates...
May 2018: Science Advances
https://www.readbyqxmd.com/read/29773959/conservation-systematics-of-the-shield-backed-trapdoor-spiders-of-the-nigrum-group-mygalomorphae-idiopidae-idiosoma-integrative-taxonomy-reveals-a-diverse-and-threatened-fauna-from-south-western-australia
#10
Michael G Rix, Joel A Huey, Steven J B Cooper, Andrew D Austin, Mark S Harvey
The aganippine shield-backed trapdoor spiders of the monophyletic nigrum -group of Idiosoma Ausserer s. l. are revised, and 15 new species are described from Western Australia and the Eyre Peninsula of South Australia: I. arenaceum Rix & Harvey, sp. n. , I. corrugatum Rix & Harvey, sp. n. , I. clypeatum Rix & Harvey, sp. n. , I. dandaragan Rix & Harvey, sp. n. , I. formosum Rix & Harvey, sp. n. , I. gardneri Rix & Harvey, sp. n. , I. gutharuka Rix & Harvey, sp. n. , I. incomptum Rix & Harvey, sp...
2018: ZooKeys
https://www.readbyqxmd.com/read/29773302/experiences-and-perceptions-of-black-men-who-have-sex-with-men-about-acquiring-hiv-a-qualitative-narrative-perspective
#11
Austin Nation, Catherine M Waters, Carol Dawson-Rose
In the United States, Black men who have sex with men (MSM), between the ages of 18 and 34 years, have the highest rates of new HIV infections. The prevalence of HIV in this population is three to four times higher than their White MSM counterparts. Twelve Black MSM from the Bay Area, nine with HIV and three without HIV, were interviewed regarding their experiences and perceived risks of acquiring HIV. Narrative analysis revealed these themes: (a) tested regularly for HIV, (b) HIV knowledge varied before arriving in San Francisco, (c) condom use typically nonexistent when under the influence of alcohol and other drugs, (d) inability to negotiate sex and condom usage, and (e) sense of anticipation, resignation, and acceptance about acquiring HIV...
April 25, 2018: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/29772956/lumbar-muscle-structure-predicts-operational-postures-in-active-duty-marines
#12
David B Berry, Bahar Shahidi, Ana E Rodríguez-Soto, Jan M Hughes-Austin, Karen R Kelly, Samuel R Ward
Study Design Cross-sectional. Background The relationship between lumbar spine posture and muscle structure is not well understood. Objectives Investigate the predictive capacity of muscle structure on lumbar spine posture in active duty Marines. Methods Fouty-three Marines were scanned using an upright magnetic resonance imaging (MRI) scanner while standing unloaded and standing, sitting, and prone on elbows with body armor. Cobb, horizontal, and sacral angles were measured. Marines were then scanned unloaded in supine using a supine MRI scanner...
May 17, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29772612/activity-and-structure-of-human-acetyl-coa-carboxylase-targeted-by-a-specific-inhibitor
#13
REVIEW
SoRi Jang, Piotr Gornicki, Jasmina Marjanovic, Ethan Bass, Toni Lurcotta, Pedro Rodriguez, Jotham Austin, Robert Haselkorn
We have studied a series of human acetyl CoA-carboxylase (ACC) 1 and ACC2 proteins with deletions and/or Ser to Ala substitutions of the known phosphorylation sites. In vitro dephosphorylation/phosphorylation experiments reveal a substantial level of phosphorylation of human ACCs produced in insect cells. Our results are consistent with AMPK phosphorylation of Ser29, Ser80 , Ser1,201 and Ser1,216 . Phosphorylation of the N-terminal regulatory domain decreases ACC1 activity, while phosphorylation of residues in the ACC central domain has no effect...
May 17, 2018: FEBS Letters
https://www.readbyqxmd.com/read/29770275/plant-fungal-bacterial-and-nitrogen-interactions-in-the-litter-layer-of-a-native-patagonian-forest
#14
Lucía Vivanco, Nicolás Rascovan, Amy T Austin
Plant-microbial interactions in the litter layer represent one of the most relevant interactions for biogeochemical cycling as litter decomposition is a key first step in carbon and nitrogen turnover. However, our understanding of these interactions in the litter layer remains elusive. In an old-growth mixed Nothofagus forest in Patagonia, we studied the effects of single tree species identity and the mixture of three tree species on the fungal and bacterial composition in the litter layer. We also evaluated the effects of nitrogen (N) addition on these plant-microbial interactions...
2018: PeerJ
https://www.readbyqxmd.com/read/29770258/local-higher-order-graph-clustering
#15
Hao Yin, Austin R Benson, Jure Leskovec, David F Gleich
Local graph clustering methods aim to find a cluster of nodes by exploring a small region of the graph. These methods are attractive because they enable targeted clustering around a given seed node and are faster than traditional global graph clustering methods because their runtime does not depend on the size of the input graph. However, current local graph partitioning methods are not designed to account for the higher-order structures crucial to the network, nor can they effectively handle directed networks...
August 2017: KDD: Proceedings
https://www.readbyqxmd.com/read/29770103/outbreak-of-seoul-virus-among-rats-and-rat-owners-united-states-and-canada-2017
#16
J L Kerins, S E Koske, J Kazmierczak, C Austin, K Gowdy, A Dibernardo
What is already known about this topic?: ​: Seoul virus, a type of hantavirus, is carried by Norway rats. Humans become infected through contact with virus shed in rat urine or droppings, or inhalation of virus particles in dust from contaminated bedding. Infected rats do not develop disease, but humans can experience symptoms ranging from mild influenza-like illness to severe disease with kidney failure and death. Although infections have been previously reported in humans after contact with wild rats, Seoul virus infections had not been reported in pet rats in the United States or Canada...
February 1, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770059/assessing-uptake-of-national-hiv-screening-and-testing-guidance-part-2-knowledge-comfort-and-practice
#17
G P Traversy, T Austin, J Yau, K Timmerman
Background: The Public Health Agency of Canada's (PHAC) HIV Screening and Testing Guide (the Guide) provides guidance to health care providers regarding who, when and how often to screen for HIV. HIV screening and testing is important in meeting the Joint United Nations Programme on HIV/AIDS' (UNAIDS) 90-90-90 targets towards HIV elimination. Objective: To determine health care providers' levels of knowledge about and comfort with aspects of HIV testing, and to determine whether their HIV testing practices are consistent with the recommendations in the Guide...
December 7, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770058/assessing-uptake-of-national-hiv-screening-and-testing-guidance-part-1-awareness-use-and-usefulness
#18
G P Traversy, T Austin, J Yau, K Timmerman
Background: In 2013, the Public Health Agency of Canada released the HIV Screening and Testing Guide (the Guide) to support routine HIV screening and testing practices of health care providers in Canada and promote early detection of new HIV cases. Little was known regarding health care providers' awareness and use of the Guide. Objective: To determine Canadian health care providers' awareness, use and perceived usefulness of the Guide. Methods: An open, anonymous online survey, including questions on awareness, use and usefulness, was developed with stakeholders, validated and pre-tested...
December 7, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29767642/regarding-the-joint-statement-from-the-american-college-of-surgeons-committee-on-trauma-acs-cot-and-the-american-college-of-emergency-physicians-acep-regarding-the-clinical-use-of-resuscitative-endovascular-balloon-occlusion-of-the-aorta-reboa
#19
Bryant K Allen, David W Callaway, Michael Gibbs, Erin Noste, Kathryn West, M Austin Johnson, David Caro, Andy Godwin
No abstract text is available yet for this article.
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29767515/correction-to-exploiting-alkylquinone-tautomerization-for-the-total-synthesis-of-calothrixin-a-and-b
#20
Luis M Mori-Quiroz, Madeline M Dekarske, Austin B Prinkki, Michael D Clift
No abstract text is available yet for this article.
May 16, 2018: Journal of Organic Chemistry
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