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https://www.readbyqxmd.com/read/28929511/dermatotoxicology-of-sulfur-mustard-historical-perspectives-from-world-war-i
#1
REVIEW
Austin Jiang, Howard Maibach
Sulfur mustard has been used as a chemical warfare agent for the past century. After its introduction by the Germans in World War I, investigators quickly began studying its impact on the human body including its deleterious effects on skin. This review focuses on two groups in particular who conducted experiments from 1917 to 1918: the United States Army at the American University Experiment Station Laboratories and Torald Sollmann at Western Reserve University. Through this work, these researchers proved far ahead of their time by anticipating dermatologic phenomena not described in the literature until later in the twentieth century...
September 19, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28927983/the-digital-divide-in-adoption-and-use-of-mobile-health-technology-among-caregivers-of-pediatric-surgery-patients
#2
Emma C Hamilton, Faiez Saiyed, Charles C Miller, Arturo Eguia, Alexandra C Fonseca, George P Baum, KuoJen Tsao, Mary T Austin
PURPOSE: The purpose of this study was to identify mobile Health (mHealth) technology utilization among caregivers of pediatric surgery patients. METHODS: We provided a modified version of the 2012 mobile health survey from the Pew Research Center to English and Spanish-speaking caregivers of children aged <18years presenting to pediatric surgical outpatient clinics from June to July of 2016. RESULTS: A total of 171 caregivers completed the survey and included 57 (34%) whites, 30 (18%) blacks, 75 (44%) Hispanics, and 6 (4%) other races...
September 1, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28927978/approaching-zero-implications-of-a-computed-tomography-reduction-program-for-pediatric-appendicitis-evaluation
#3
K Tinsley Anderson, Marisa Bartz-Kurycki, Mary T Austin, Akemi Kawaguchi, Susan D John, Lillian S Kao, KuoJen Tsao
PURPOSE: Because of awareness of iatrogenic radiation exposure, there is a national trend of diminishing computed tomography (CT) use for pediatric suspected appendicitis. The purpose of this study was to evaluate the effects of a CT reduction program for evaluation of appendicitis. METHODS: A multidisciplinary group (emergency medicine, radiology, and surgery) at a children's hospital developed a reduction program which included: ultrasound (U/S) first (2012), magnetic resonance imaging (MRI) second (2014), and standardized U/S reports (2016)...
September 5, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28926501/moral-distress-and-associated-factors-among-baccalaureate-nursing-students-a-multisite-descriptive-study
#4
Lorretta Krautscheid, Deborah A DeMeester, Valorie Orton, Austin Smith, Conor Livingston, Susan M McLennon
AIM: The three study aims were to assess moral distress among senior baccalaureate nursing students, describe ethical dilemmas contributing to their moral distress in practice settings, and identify reasons for inaction when encountering dilemmas. BACKGROUND: Previous studies have linked postlicensure nurses' moral distress to compassion fatigue, frustration, and turnover. Little is known about this phenomenon in students. METHOD: This study employed a descriptive cross-sectional survey design to measure moral distress and reasons for not taking action across three academic sites (N = 267)...
September 19, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28925015/erosive-pustular-dermatosis-of-the-scalp-after-aplasia-cutis-congenita-in-a-9-year-old-patient-a-5-year-follow-up
#5
Raymond Fertig, Austin Maddy, Débora Cadore de Farias, Sandro Simão Corrêa Filho, Marcelo Rigatti, Antonella Tosti
Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory skin disease that occurs mainly in elderly adults with a history of trauma to the scalp, but a few cases of EPDS in children have been reported. We report a rare case of EPDS after aplasia cutis congenita in a child.
September 19, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28922379/elevating-serotonin-pre-partum-alters-the-holstein-dairy-cow-hepatic-adaptation-to-lactation
#6
Samantha R Weaver, Allan S Prichard, Noah L Maerz, Austin P Prichard, Elizabeth L Endres, Lorenzo E Hernández-Castellano, Matthew S Akins, Rupert M Bruckmaier, Laura L Hernandez
Serotonin is known to regulate energy and calcium homeostasis in several mammalian species. The objective of this study was to determine if pre-partum infusions of 5-hydroxytryptophan (5-HTP), the immediate precursor to serotonin synthesis, could modulate energy homeostasis at the level of the hepatocyte in post-partum Holstein and Jersey dairy cows. Twelve multiparous Holstein cows and twelve multiparous Jersey cows were intravenously infused daily for approximately 7 d pre-partum with either saline or 1 mg/kg bodyweight of 5-HTP...
2017: PloS One
https://www.readbyqxmd.com/read/28922207/sweet-sixteen-the-prospective-clinical-trials-of-john-l-cameron-md-the-clinician-scientist-from-alternate-allocation-to-randomized-controlled-trials
#7
Charles J Yeo
: The era of randomized controlled trials was ushered in by the British epidemiologist-statistician Austin Bradford Hill, with his work on the use of streptomycin in patients with tuberculosis. John L. Cameron, can be linked to 16 prospective clinical trials over his career thus far, starting with alternate-allocation trials and transitioning to prospective, randomized, placebo-controlled trials. These trials studied various topics in surgery-from pancreatitis to surgical site infections, to drain trials, a trial in Crohn disease and multiple trials in pancreatic surgery and cancer...
September 15, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28922016/high-degree-of-variability-in-reporting-of-clinical-and-patient-reported-outcomes-after-hip-arthroscopy
#8
Austin V Stone, Cale A Jacobs, T David Luo, Molly C Meadows, Shane J Nho, Allston J Stubbs, Eric C Makhni
BACKGROUND: Hip arthroscopy for the treatment of intra-articular pathology is a rapidly expanding field. Outcome measures should be reported to document the efficacy of arthroscopic procedures; however, the most effective outcome measures are not established. PURPOSE: To evaluate the variability in outcomes reported after hip arthroscopy and to compare the responsiveness of patient-reported outcome (PRO) instruments. STUDY DESIGN: Systematic review...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28918718/who-gets-social-support-who-gives-it-and-how-it-s-related-to-recipient-s-mood
#9
J Austin Williamson, Michael W O'Hara
We sought to identify personal characteristics associated with receiving and perceiving social support, and characteristics of support providers who give the most support and are perceived as the most available. In samples of students ( n = 755) and community adults ( n = 430), we found that people who were younger, female, more extraverted, more conscientious, and more open received and perceived more support. Female providers and romantic partners were associated with more support whereas coworkers were associated with less...
October 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28918268/a-structural-mri-study-of-excoriation-skin-picking-disorder-and-its-relationship-to-clinical-severity
#10
Michael D Harries, Samuel R Chamberlain, Sarah A Redden, Brian L Odlaug, Austin W Blum, Jon E Grant
Excoriation (skin-picking) disorder (SPD) shares symptomology with other obsessive-compulsive and related disorders. Few studies, however, have examined the neurological profile of patients with SPD. This study examined differences in cortical thickness and basal ganglia structural volumes between 20 individuals with SPD and 16 healthy controls using magnetic resonance imaging (MRI). There were no significant differences in demographic variables (age, gender, education and race) between groups. All subjects completed a structural MRI scan and completed a battery of clinical assessments focusing on SPD symptom severity, depression and anxiety symptoms, and quality of life...
September 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28918010/corrigendum-to-extending-the-distributed-lag-model-framework-to-handle-chemical-mixtures-environ-res-156-2017-253-264
#11
Ghalib A Bello, Manish Arora, Christine Austin, Megan K Horton, Robert O Wright, Chris Gennings
No abstract text is available yet for this article.
September 13, 2017: Environmental Research
https://www.readbyqxmd.com/read/28917719/polymorphisms-in-manganese-transporters-show-developmental-stage-and-sex-specific-associations-with-manganese-concentrations-in-primary-teeth
#12
Karin Wahlberg, Manish Arora, Austen Curtin, Paul Curtin, Robert O Wright, Donald R Smith, Roberto G Lucchini, Karin Broberg, Christine Austin
BACKGROUND: Manganese (Mn) is an essential metal that can become neurotoxic at elevated levels with negative consequences on neurodevelopment. We have evaluated the influence of single nucleotide polymorphisms (SNPs) in Mn transporter genes SLC30A10 and SLC39A8 on Mn concentrations in dentine, a validated biomarker that reflects Mn tissue concentrations early in life. METHODS: The study included 195 children with variable environmental Mn exposure. Mn concentrations in dentine representing fetal, early postnatal and early childhood developmental periods were measured using laser ablation-inductively coupled plasma mass spectrometry...
September 13, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28916838/functionally-distinct-tendons-from-elastin-haploinsufficient-mice-exhibit-mild-stiffening-and-tendon-specific-structural-alteration
#13
Jeremy D Eekhoff, Fei Fang, Lindsey G Kahan, M G Espinosa, Austin J Cocciolone, Jessica E Wagenseil, Robert P Mecham, Spencer P Lake
Elastic fibers are present in low quantities in tendon, where they are located both within fascicles near tenocytes and more broadly in the interfascicular matrix. While elastic fibers have long been known to be significant in the mechanics of elastin-rich tissue (i.e. vasculature, skin, lungs), recent studies have suggested a mechanical role for elastic fibers in tendons that is dependent on specific tendon function. However, the exact contribution of elastin to properties of different types of tendons (e...
September 16, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28915293/children-s-health-must-remain-a-focus-in-the-recovery-from-hurricane-harvey
#14
Aaron E Carroll, Austin B Frakt
No abstract text is available yet for this article.
September 15, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28913837/practical-recommendations-for-reporting-fine-gray-model-analyses-for-competing-risk-data
#15
Peter C Austin, Jason P Fine
In survival analysis, a competing risk is an event whose occurrence precludes the occurrence of the primary event of interest. Outcomes in medical research are frequently subject to competing risks. In survival analysis, there are 2 key questions that can be addressed using competing risk regression models: first, which covariates affect the rate at which events occur, and second, which covariates affect the probability of an event occurring over time. The cause-specific hazard model estimates the effect of covariates on the rate at which events occur in subjects who are currently event-free...
September 15, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28912200/development-and-validation-of-electronic-quality-measures-to-assess-care-for-patients-with-transient-ischemic-attack-and-minor-ischemic-stroke
#16
Dawn M Bravata, Laura J Myers, Eric Cheng, Mathew Reeves, Fitsum Baye, Zhangsheng Yu, Teresa Damush, Edward J Miech, Jason Sico, Michael Phipps, Alan Zillich, Jason Johanning, Seemant Chaturvedi, Curt Austin, Jared Ferguson, Bailey Maryfield, Kathy Snow, Susan Ofner, Glenn Graham, Rachel Rhude, Linda S Williams, Greg Arling
BACKGROUND: Despite interest in using electronic health record (EHR) data to assess quality of care, the accuracy of such data is largely unknown. We sought to develop and validate transient ischemic attack and minor ischemic stroke electronic quality measures (eQMs) using EHR data. METHODS AND RESULTS: A random sample of patients with transient ischemic attack or minor ischemic stroke, cared for in Veterans Health Administration facilities (fiscal year 2011), was identified...
September 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28912168/alternative-polyadenylation-of-prelid1-regulates-mitochondrial-ros-signaling-and-cancer-outcomes
#17
Austin E Gillen, Heather M Brechbuhl, Tomomi M Yamamoto, Enos C Kline, Manoj Pillai, Jay Hesselberth, Peter Kabos
Disruption of post-transcriptional gene regulation is a critical step in oncogenesis that can be difficult to observe using traditional molecular techniques. To overcome this limitation, a modified polyadenylation site sequencing (PAS-seq) protocol was used to generate a genome-wide map of alternative polyadenylation (APA) events in human primary breast tumor specimens and matched normal tissue. This approach identified an APA event in the PRELID1 mRNA that enhances its steady state level and translational efficiency, and is a strong breast cancer subtype-dependent predictor of patient clinical outcomes...
September 14, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28911814/the-effect-of-patient-gender-on-outcomes-after-reverse-total-shoulder-arthroplasty
#18
Stephanie E Wong, Austin A Pitcher, David Y Ding, Nicola Cashman, Alan L Zhang, C Benjamin Ma, Brian T Feeley
BACKGROUND: Gender differences may exist for patients undergoing shoulder arthroplasty. Limited data suggest that women may have worse preoperative disability and outcomes. Our objective was to determine whether gender influences preoperative disability and patient-reported outcomes after reverse total shoulder arthroplasty. METHODS: Data were prospectively collected for patients who underwent reverse total shoulder arthroplasty for rotator cuff arthropathy or osteoarthritis with a rotator cuff tear at a single institution between 2009 and 2015...
September 11, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28911318/development-and-optimization-of-a-high-titer-recombinant-lentivirus-system
#19
Austin Storck, James Ludtke, Leisha Kopp, Laura Juckem
To enable simple and effective high titer recombinant lentivirus production, we examined key parameters for the generation of lentivirus including: transfection optimization, media change, incubation time and DNA vector selection. These results illustrate the importance of optimizing transfection processes for high titer recombinant lentivirus production.
September 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28910146/management-of-ards-and-refractory-hypoxemia-a-multicenter-observational-study
#20
Erick H Duan, Neill Kj Adhikari, Frederick D'Aragon, Deborah J Cook, Sangeeta Mehta, Waleed Alhazzani, Ewan Goligher, Emmanuel Charbonney, Yaseen M Arabi, Tim Karachi, Alexis F Turgeon, Lori Hand, Qi Zhou, Peggy Austin, Jan Friedrich, Francois Lamontagne, François Lauzier, Rakesh Patel, John Muscedere, Richard Hall, Pierre Aslanian, Thomas Piraino, Martin Albert, Sean M Bagshaw, Mike Jacka, Gordon Wood, William Henderson, Delbert Dorscheid, Niall D Ferguson, Maureen O Meade
RATIONALE: Clinicians' current practice patterns in the management of acute respiratory distress syndrome (ARDS) and refractory hypoxemia are not well described. OBJECTIVES: To describe mechanical ventilation strategies and treatment adjuncts for adults with ARDS including refractory hypoxemia. METHODS: Prospective cohort study (March 2014-February 2015) of mechanically ventilated adults with moderate-to-severe ARDS requiring FiO2 ≥0.50 in 24 ICUs...
September 14, 2017: Annals of the American Thoracic Society
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