keyword
https://read.qxmd.com/read/37957357/circular-permutation-at-azurin-s-active-site-slows-down-its-folding
#21
JOURNAL ARTICLE
Debanjana Das, Sri Rama Koti Ainavarapu
Circular permutation (CP) is a technique by which the primary sequence of a protein is rearranged to create new termini. The connectivity of the protein is altered but the overall protein structure generally remains unperturbed. Understanding the effect of CP can help design robust proteins for numerous applications such as in genetic engineering, optoelectronics, and improving catalytic activity. Studies on different protein topologies showed that CP usually affects protein stability as well as unfolding rates...
November 13, 2023: Journal of Biological Inorganic Chemistry: JBIC
https://read.qxmd.com/read/37954971/estimation-of-the-spatial-extent-of-the-transient-gain-drop-in-a-microchannel-plate
#22
JOURNAL ARTICLE
Hiroshi Kobayashi, Toshinobu Hondo, Yasuo Kanematsu, Motohiro Suyama, Michisato Toyoda
The gain of the microchannel plate temporally drops after an ion initiates an electron avalanche. Electron multiplication was expected to deplete the charge from the microchannel wall and produce the depleted charge (wall charge). Moreover, it was reported that the gain drop occurred not only in the activated channels, where the electrons are multiplied, but also in the surrounding channels. One mechanism of the gain-drop spatial extension has been considered as that the wall charges in the activated channels change the electric field in the surrounding channels...
2023: Mass Spectrometry
https://read.qxmd.com/read/37929200/numerical-study-of-critical-straight-frown-and-chevron-incisions-in-small-incision-cataract-surgery
#23
JOURNAL ARTICLE
Yang Han, Nan Qi
Introduction: When an intraocular lens (IOL) injector is inserted through a pre-cut corneal incision (e.g., an empirical size of 2.2 mm) during small incision cataract surgery, uncontrollable tearing to the corneal tissue may occur, which is highly associated with the incision shape, size, and location. The goal of this numerical study was to investigate the optimal incision scheme amongst three typical shapes, i.e., straight, frown, and chevron incisions using mechanical modeling and finite element analysis...
2023: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/37922633/hallux-valgus-an-observational-study-on-patient-characteristics-surgical-treatment-and-pre-operative-hrqol-from-the-swedish-foot-and-ankle-register-swefoot
#24
JOURNAL ARTICLE
Ann-Charlott Söderpalm, Fredrik Montgomery, Katarina Nilsson Helander, Maria C Cöster
INTRODUCTION: Hallux valgus (HV) is a common condition with impact on pain, function and HrQoL. International consensus does not exist on operative treatment of HV and population-level data regarding surgical treatment of HV is lacking. In this study we aimed to present base-line data from surgically treated HV patients reported to the Swedish register for foot and ankle surgery (Swefoot) during the period 2014-2021. MATERIAL AND METHODS: In total, 7543 feet in 6770 patients were analyzed regarding patient characteristics, grading of HV, surgical procedures and pre-operative PROMs Euroqol-5 Dimension-3 L (EQ-5D-3 L) and Self-reported Foot and Ankle Score (SEFAS)...
December 2023: Foot
https://read.qxmd.com/read/37915688/giant-sacrococcygeal-teratoma-in-an-infant-a-case-report-with-a-literature-review
#25
JOURNAL ARTICLE
Wirya N Sabir, Sasan M Ahmed, Karzan M Hasan, Bilal A Mohammed, Honar Othman Kareem, Zana B Najmadden, Berun A Abdalla, Rawezh Q Salih, Shvan H Mohammed, Fahmi H Kakamad, Hevar A Azaldeen
INTRODUCTION AND IMPORTANCE: A sacrococcygeal teratoma (SCT) is a rare embryonal tumor that emerges in the sacrococcygeal area. It affects one in every 35 000-40 000 live births. Herein, we report a case of a substantial SCT in a neonate. CASE PRESENTATION: A neonate girl from consanguineous parents was delivered by cesarean section with a large mass (18×17 cm) in the sacrococcygeal area. The baby's birth weight was 5 kg, of which 2.5 belonged to the mass...
November 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/37846094/changes-in-radiographic-alignment-following-metatarsophalangeal-fusion-distal-metatarsal-osteotomy-and-lapidus
#26
JOURNAL ARTICLE
Timothy Dusch, Alexander Guareschi, Andrew Moore, Caroline Hoch, Christopher E Gross, Daniel J Scott
BACKGROUND: The purpose of this study is to evaluate the effect of the different surgical treatments for hallux valgus on various radiographic measures of bunion correction. METHODS: A retrospective cohort study was conducted at a single academic medical center involving 2 fellowship-trained foot and ankle surgeons. One hundred and nineteen feet (110 patients) were included. Procedures included first metatarsophalangeal (MTP) arthrodesis (n = 88), Chevron and/or Scarf osteotomy (n = 23), and Lapidus (n = 8)...
October 16, 2023: Foot & Ankle Specialist
https://read.qxmd.com/read/37817957/co-crystal-sustained-by-%C3%AF-type-halogen-bonding-inter-actions-between-1-4-di-iodo-perchloro-benzene-and-naphthalene
#27
JOURNAL ARTICLE
Eric Bosch, Eric W Reinheimer, Daniel K Unruh, Ryan H Groeneman
The formation and crystal structure of a co-crystal based upon 1,4-di-iodo-perchloro-benzene (C6 I2 Cl4 ) as the halogen-bond donor along with naphthalene (nap) as the acceptor is reported. The co-crystal [systematic name: 1,2,4,5-tetra-chloro-3,6-di-iodo-benzene-naphthalene, (C6 I2 Cl4 )·(nap)] generates a chevron-like structure that is held together primarily by π-type halogen bonds ( i.e . C-I⋯π contacts) between the components. In addition, C6 I2 Cl4 also inter-acts with the acceptor via C-Cl⋯π contacts that help stabilize the co-crystal...
October 1, 2023: Acta Crystallographica. Section E, Crystallographic Communications
https://read.qxmd.com/read/37790831/techniques-and-fixation-of-olecranon-osteotomy-a-systematic-review
#28
JOURNAL ARTICLE
Shawn D Feinstein, Anthony V Paterno, Andrew D Allen, Emily Jewell, Sarah T Wright, Reid W Draeger
PURPOSE: We aimed to characterize the incidence of complications regarding olecranon osteotomy, looking more specifically at the type of osteotomy and the fixation construct used to repair the osteotomy. METHODS: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a comprehensive search was performed. A study was included if it was an adult clinical study, a transverse or chevron olecranon osteotomy was performed, and the study explicitly states the fixation construct used to repair the osteotomy...
September 2023: Journal of hand surgery global online
https://read.qxmd.com/read/37777043/biomechanics-of-subscapularis-v-shaped-tenotomy-compared-to-standard-tenotomy
#29
JOURNAL ARTICLE
Brett D Haislup, Sierra Lindsey, Rae Tarapore, Pooyan Abbasi, Melissa A Wright, Anand M Murthi
INTRODUCTION: Subscapularis function is critical after anatomic total shoulder arthroplasty (aTSA). Recently, however, a technique has been described that features a chevron or V-shaped subscapularis tendon cut (VT). This biomechanical study compared repair of the standard tenotomy (ST), made perpendicular to the subscapularis fibers, to repair of the novel VT using cyclic displacement, creep, construct stiffness, and load to failure. METHODS: This biomechanical study used six pairs of fresh frozen paired cadaveric shoulder specimens...
September 28, 2023: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/37750651/effect-of-scarf-and-chevron-combined-with-akin-on-postoperative-balance-in-patients-with-moderate-to-severe-foot-bunion
#30
JOURNAL ARTICLE
J-D Wu, Z-U Chen, Y-Z Qi, X-Y Li, X-U Pan, M-A Hong, B-R Jin, Z-U Ma
OBJECTIVE: The aim of this study was to analyze the effect of Scarf and Chevron combined with Akin on a postoperative balance of patients with moderate to severe foot bunion. PATIENTS AND METHODS: One hundred (100 feet) patients with moderate to severe bunion cysts treated at our hospital from January 2019 to January 2022 were retrospectively selected as subjects and divided into 2 groups according to their surgical procedure. The control group received Scarf combined with Akin, and the study group received Chevron combined with Akin...
September 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37737775/identifying-origin-of-nonpulmonary-vein%C3%A2-triggers-using-2-stationary-linear%C3%A2-decapolar-catheters-a-novel-algorithm
#31
JOURNAL ARTICLE
Munveer Thind, Martín R Arceluz, Irene Lucena-Padros, Maciej Kubala, Maiwand Mirwais, Weeranun Bode, Maxime Cerantola, Alan Sugrue, Christoffel Van Niekerk, Aaron Vigdor, Neel A Patel, Ahmed B AlSalem, Erica S Zado, Ramanan Kumareswaran, David Lin, Jeffrey S Arkles, Fermin C Garcia, Gustavo S Guandalini, Timothy M Markman, Michael P Riley, Rajat Deo, Robert D Schaller, Saman Nazarian, Sanjay Dixit, Andrew E Epstein, Gregory E Supple, David S Frankel, Cory M Tschabrunn, Pasquale Santangeli, David J Callans, Matthew C Hyman, Francis E Marchlinski
BACKGROUND: Targeting nonpulmonary vein triggers (NPVTs) of atrial fibrillation (AF) after pulmonary vein isolation can be challenging. NPVTs are often single ectopic beats with a surface P-wave obscured by a QRS or T-wave. OBJECTIVES: The goal of this study was to construct an algorithm to regionalize the site of origin of NPVTs using only intracardiac bipolar electrograms from 2 linear decapolar catheters positioned in the postero-lateral right atrium (along the crista terminalis with the distal bipole pair in the superior vena cava) and in the proximal coronary sinus (CS)...
August 16, 2023: JACC. Clinical Electrophysiology
https://read.qxmd.com/read/37718391/management-strategy-and-outcomes-of-sacrococcygeal-teratoma-an-egyptian-multicenter-experience
#32
JOURNAL ARTICLE
Ahmed Elgendy, Amr Abdelhamid AbouZeid, Mohamed El-Debeiky, Mahmoud Mostafa, Mohammed Hamada Takrouney, Mohamed Abouheba, Ahmed Khairi, Sameh Shehata, Sherif M Shehata
OBJECTIVES: Nationwide criteria regarding patients with sacrococcygeal teratoma (SCT) are still lacking in Egypt. We aimed to present a multicenter study regarding the management and outcomes of this tumor to evaluate our national treatment strategy. METHODS: A retrospective analysis including all patients with SCT who were managed at four major Egyptian centers between 2013 and 2023. Clinical data, surgical approaches, and short- and long-term outcomes were discussed...
September 18, 2023: World Journal of Surgical Oncology
https://read.qxmd.com/read/37634477/a-new-chevron-electromagnetic-acoustic-transducer-design-for-generating-shear-horizontal-guided-wave
#33
JOURNAL ARTICLE
Ambuj K Gautam, Ching-Chung Yin, Bishakh Bhattacharya
Guided wave electromagnetic acoustic transducers (EMATs) have a significant role in non-destructive testing and structural health monitoring. It can generate horizontally polarized shear waves propagating axially or circumferentially to characterize the shape and orientation of pipeline defects. This work proposes a new Chevron pattern-like coil structure design with a periodic permanent magnet (PPM) EMAT configuration. This specific design of the EMAT coil can generate a bi-directional shear horizontal wave (SH-wave) and reduce the side lobes...
August 19, 2023: Ultrasonics
https://read.qxmd.com/read/37594477/precision-graphene-nanoribbon-heterojunctions-by-chain-growth-polymerization
#34
JOURNAL ARTICLE
Jinjiang Zhang, Kun Liu, Yao Xiao, Xiuling Yu, Li Huang, Hong-Jun Gao, Ji Ma, Xinliang Feng
Graphene nanoribbons (GNRs) are considered promising candidates for next-generation nanoelectronics. In particular, GNR heterojunctions have received considerable attention due to their exotic topological electronic phases at the heterointerface. However, strategies for their precision synthesis remain at a nascent stage. Here, we report a novel chain-growth polymerization strategy that allows for constructing GNR heterojunction with N=9 armchair and chevron GNRs segments (9-AGNR/cGNR). The synthesis involves a controlled Suzuki-Miyaura catalyst-transfer polymerization (SCTP) between 2-(6'-bromo-4,4''-ditetradecyl-[1,1':2',1''-terphenyl]-3'-yl) boronic ester (M1) and 2-(7-bromo-9,12-diphenyl-10,11-bis(4-tetradecylphenyl)-triphenylene-2-yl) boronic ester (M2), followed by the Scholl reaction of the obtained block copolymer (poly-M1/M2) with controlled Mn (18k) and narrow Đ (1...
August 18, 2023: Angewandte Chemie
https://read.qxmd.com/read/37590289/republication-of-evidence-versus-practice-operative-treatment-preferences-in-hallux-valgus
#35
JOURNAL ARTICLE
Peter C Noback, David P Trofa, J Turner Vosseller
BACKGROUND: There is substantial variability in the operative treatment of hallux valgus despite the existence of high quality evidence to guide treatment decisions. The purpose of this study was to determine the current trends in the treatment of mild, moderate, and severe hallux valgus and if greater degrees of consensus correlate with the presence of higher-level evidence. METHODS: Members of the American Orthopaedic Foot & Ankle Society completed a 14-item survey...
July 2023: Foot & ankle orthopaedics
https://read.qxmd.com/read/37537622/association-between-the-distal-tibiofibular-syndesmosis-morphology-classification-and-ankle-osteoarthritis-a-retrospective-study
#36
JOURNAL ARTICLE
Lei Huang, XiaoHong Zhang, Siyi Yang, Jiwen Qing, Wangyu Wu, Houyin Shi, Dingxuan Wang, Lei Zhang
BACKGROUND: Syndesmosis injury is proposed to contribute to ankle stability and osteoarthritis (OA). However, whether distal tibiofibular syndesmosis structure is closely related to ankle OA is unclear. We hypothesized that different DTS morphology classifications would affect the biomechanics properties in ankle OA. The study aimed to determine the association between the distal tibiofibular syndesmosis (DTS) morphological classification and ankle OA. METHODS: This is a retrospective study examining imaging data of 147 patients (87 males and 60 females) with ankle OA...
August 3, 2023: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/37532939/tdp-43-forms-amyloid-filaments-with-a-distinct-fold-in-type-a-ftld-tdp
#37
JOURNAL ARTICLE
Diana Arseni, Renren Chen, Alexey G Murzin, Sew Y Peak-Chew, Holly J Garringer, Kathy L Newell, Fuyuki Kametani, Andrew C Robinson, Ruben Vidal, Bernardino Ghetti, Masato Hasegawa, Benjamin Ryskeldi-Falcon
The abnormal assembly of TAR DNA-binding protein 43 (TDP-43) in neuronal and glial cells characterizes nearly all cases of amyotrophic lateral sclerosis (ALS) and around half of cases of frontotemporal lobar degeneration (FTLD)1,2 . A causal role for TDP-43 assembly in neurodegeneration is evidenced by dominantly inherited missense mutations in TARDBP, the gene encoding TDP-43, that promote assembly and give rise to ALS and FTLD3-7 . At least four types (A-D) of FTLD with TDP-43 pathology (FTLD-TDP) are defined by distinct brain distributions of assembled TDP-43 and are associated with different clinical presentations of frontotemporal dementia8 ...
August 2, 2023: Nature
https://read.qxmd.com/read/37518614/a-new-species-of-the-fish-louse-genus-dipteropeltis-calman-1912-crustacea-branchiura-from-peru
#38
JOURNAL ARTICLE
Lyra M Gaboardi, Lawrence E Reeves, Germán Augusto Murrieta Morey, Daniel L Stanton, Ryan M Carney
Dipteropeltis is a poorly described genus of fish louse endemic to South America. In a small blackwater region within Loreto, Peru, 13 adult and juvenile specimens of an unidentified species of Dipteropeltis Calman, 1912, as well as one adult specimen of D. hirundo Calman, 1912, were observed and collected. Scanning electron and light micrographs were acquired to examine and measure key features of these specimens. Morphological differences from the two known species of Dipteropeltis, D. hirundo and D. campanaformis Neethling et al...
July 7, 2023: Zootaxa
https://read.qxmd.com/read/37458528/perspectives-and-trends-for-minimally-invasive-surgery-for-hallux-valgus-deformity-in-the-asia-pacific-region
#39
JOURNAL ARTICLE
Chin Yik Tan, Gowreeson Thevendran
BACKGROUND: Evolving evidence and improved instrumentation have led to increasing importance of minimally invasive surgery (MIS) surgery in the treatment of hallux valgus deformity. This study aims to investigate the current trends of the practice of MIS hallux valgus surgery in the Asia Pacific region. METHOD: A survey was sent via email to 30 fellowship-trained foot and ankle surgeons in 11 Asia Pacific countries, all registered with their respective national orthopaedic societies...
2023: Journal of Orthopaedic Surgery
https://read.qxmd.com/read/37457449/structural-analysis-of-si-oet-4-deposits-on-au-111-sio-2-substrates-at-the-nanometer-scale-using-focused-electron-beam-induced-deposition
#40
JOURNAL ARTICLE
Nigel J Mason, Maria Pintea, István Csarnovics, Tamás Fodor, Zita Szikszai, Zsófia Kertész
The focused electron beam-induced deposition (FEBID) process was used by employing a GeminiSEM with a beam characteristic of 1 keV and 24 pA to deposit pillars and line-shaped nanostructures with heights between 9 nm and 1 μm and widths from 5 nm to 0.5 μm. All structures have been analyzed to their composition looking at a desired Si/O/C content measuring a 1:2:0 ratio. The C content of the structure was found to be ∼over 60% for older deposits kept in air (∼at room temperature) and less than 50% for later deposits, only 12 h old...
July 11, 2023: ACS Omega
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