keyword
https://read.qxmd.com/read/38543695/initial-efficacy-of-the-covid-19-mrna-vaccine-booster-and-subsequent-breakthrough-omicron-variant-infection-in-patients-with-b-cell-non-hodgkin-s-lymphoma-a-single-center-cohort-study
#1
JOURNAL ARTICLE
Makoto Saito, Akio Mori, Takashi Ishio, Mirei Kobayashi, Shihori Tsukamoto, Sayaka Kajikawa, Emi Yokoyama, Minoru Kanaya, Koh Izumiyama, Haruna Muraki, Masanobu Morioka, Takeshi Kondo
It has been suggested that the effect of coronavirus disease 2019 (COVID-19) booster vaccination in patients with B-cell non-Hodgkin's lymphoma (B-NHL) is inferior to that in healthy individuals. However, differences according to histological subtype or treatment status are unclear. In addition, there has been less research on patients who subsequently develop breakthrough infections. We investigated the effects of the first COVID-19 booster vaccination for patients with B-NHL and the clinical features of breakthrough infections in the Omicron variant era...
February 21, 2024: Viruses
https://read.qxmd.com/read/38542233/b-cell-activation-biomarkers-in-salivary-glands-are-related-to-lymphomagenesis-in-primary-sj%C3%A3-gren-s-disease-a-pilot-monocentric-exploratory-study
#2
JOURNAL ARTICLE
Dario Bruno, Barbara Tolusso, Gianmarco Lugli, Clara Di Mario, Luca Petricca, Simone Perniola, Laura Bui, Roberta Benvenuto, Gianfranco Ferraccioli, Stefano Alivernini, Elisa Gremese
Primary Sjögren's disease is primarily driven by B-cell activation and is associated with a high risk of developing non-Hodgkin's lymphoma (NHL). Over the last few decades, microRNA-155 (miR-155) has arisen as a key regulator of B-cells. Nevertheless, its role in primary Sjögren's disease remains elusive. Thus, the purpose of this study was (i) to explore miR-155, B-cell activating factor (BAFF)-receptor (BAFF-R), and Interleukin 6 receptor (IL-6R) expression in the labial salivary glands (LSG) of patients with primary Sjögren's disease, aiming to identify potential B-cell activation biomarkers related to NHL development...
March 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541877/a-comprehensive-two-decade-analysis-of-lymphoma-incidence-patterns-in-saudi-arabia
#3
JOURNAL ARTICLE
Ahmed M Basudan, Mohammed Althani, Manal Abudawood, Raed Farzan, Yazeed Alshuweishi, Mohammad A Alfhili
Background: Lymphomas account for approximately 10% of all cancer cases among the Saudi population. Even when separated, Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) are in the top ten most commonly diagnosed cancers among Saudi men and women. Despite the substantial cost of HL and NHL to public health, the resources to assess their impact are insufficient. This study provides a two-decade detailed assessment of lymphoma incidence trends in the Saudi population. Methods: Analysis of the Saudi Cancer Registry (SCR) data for various incidence metrics from 2001 to 2020 was conducted...
March 13, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38538318/extranodal-nk-t-cell-lymphoma-with-localized-relapse-in-bone-marrow-of-lower-leg-detected-using-pet-ct
#4
JOURNAL ARTICLE
Takahisa Nakamura, Hiro Tatetsu, Yusuke Higuchi, Shinya Endo, Shinya Shiraishi, Koichi Kawanaka, Daisuke Imakane, Miyu Sonoda, Rie Furuta, Takafumi Shichijo, Yumi Honda, Kennosuke Karube, Yoshiki Mikami, Kisato Nosaka, Masao Matsuoka, Jun-Ichirou Yasunaga
Extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is a rare subtype of non-Hodgkin lymphoma (NHL) with poor prognosis, particularly in relapsed or refractory patients. Thus, timely detection of relapse and appropriate disease management are crucial. We present two patients with ENKTL, wherein positron emission tomography-computed tomography (PET-CT) with total-body coverage after induction therapy, detected newly relapsed regions in the bone marrow of the lower leg prior to progression. Case 1: A 47-year-old woman with nasal obstruction, showing 18F-fluoro-deoxyglucose (FDG) uptake in the nasal cavity (Lugano stage IE)...
2024: Journal of Clinical and Experimental Hematopathology: JCEH
https://read.qxmd.com/read/38536893/urinary-proteomics-reveals-biological-processes-related-to-acute-kidney-injury-in-bothrops-atrox-envenomings
#5
JOURNAL ARTICLE
Lisele Maria Brasileiro-Martins, Sofia Angiole Cavalcante, Thaís Pinto Nascimento, Alexandre Vilhena Silva-Neto, Marlon Dias Mariano Santos, Amanda C Camillo-Andrade, Juliana de Saldanha da Gama Fischer, Caroline Coelho Ferreira, Lucas Barbosa Oliveira, Marco Aurelio Sartim, Allyson Guimarães Costa, Manuela B Pucca, Fan Hui Wen, Ana Maria Moura-da-Silva, Jacqueline Sachett, Paulo Costa Carvalho, Priscila Ferreira de Aquino, Wuelton M Monteiro
Acute kidney injury (AKI) is a critical systemic complication caused by Bothrops envenoming, a neglected health problem in the Brazilian Amazon. Understanding the underlying mechanisms leading to AKI is crucial for effectively mitigating the burden of this complication. This study aimed to characterize the urinary protein profile of Bothrops atrox snakebite victims who developed AKI. We analyzed three groups of samples collected on admission: healthy subjects (controls, n = 10), snakebite victims who developed AKI (AKI, n = 10), and those who did not evolve to AKI (No-AKI, n = 10)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38532527/management-of-vaccinations-in-patients-with-non-hodgkin-lymphoma
#6
REVIEW
Michele Merli, Andrea Costantini, Silvio Tafuri, Davide Fiore Bavaro, Carla Minoia, Erika Meli, Stefano Luminari, Guido Gini
Vaccinations are fundamental tools in preventing infectious diseases, especially in immunocompromised patients like those affected by non-Hodgkin lymphomas (NHLs). The COVID-19 pandemic made clinicians increasingly aware of the importance of vaccinations in preventing potential life-threatening SARS-CoV-2-related complications in NHL patients. However, several studies have confirmed a significant reduction in vaccine-induced immune responses after anti-CD20 monoclonal antibody treatment, thus underscoring the need for refined immunization strategies in NHL patients...
March 26, 2024: British Journal of Haematology
https://read.qxmd.com/read/38531760/car-t-cell-therapy-a-collaboration-between-authorized-treatment-centers-and-community-oncologists
#7
REVIEW
Michael R Bishop, Gary E Kay
With the approval of the first CAR T-cell products for hematological malignancies in 2017, these autologous cell therapies have changed the treatment paradigm for patients with relapsed or refractory (r/r) non-Hodgkin lymphoma (NHL), who have a poor prognosis and few effective treatment options. Despite the demonstrated clinical benefit in patients with r/r diffuse large B-cell lymphoma, mantle cell lymphoma, and follicular lymphoma, many patients who are eligible for CAR T-cell therapies do not receive them or are treated with CAR T cells as a later line of therapy at advanced stages of disease...
February 22, 2024: Seminars in Oncology
https://read.qxmd.com/read/38531057/impact-of-race-and-social-determinants-of-health-on-outcomes-in-patients-with-aggressive-b-cell-nhl-treated-with-car-t
#8
JOURNAL ARTICLE
Reem Karmali, Rushad Machhi, Narendranath Epperla, Geoffrey Shouse, Jason T Romancik, Tamara K Moyo, Vaishalee P Kenkre, Thomas A Ollila, Lindsey A Fitzgerald, Brian T Hess, Kevin A David, Ishan Roy, Joanna C Zurko, Sayan Mullick Chowdhury, Kaitlin Annunzio, Robert Ferdman, Rahul S Bhansali, Elyse I Harris, Jieqi Liu, Imran A Nizamuddin, Shuo Ma, Jonathan Moreira, Jane N Winter, Barbara Pro, Deborah M Stephens, Alexey V Danilov, Nirav N Shah, Jonathon B Cohen, Stefan K Barta, Pallawi Torka, Leo I Gordon
Healthcare disparities driven by multiple social, economic, and/or environmental factors lead to inequalities in health outcomes. CAR-T cell immunotherapy is an effective therapy for relapsed/refractory B-cell non-Hodgkin lymphoma (r/r B-NHL). However, data are limited on the impact of the convergence of race and social determinants of health on outcomes for patients treated with CAR-T therapy. We examined the impact of interactions between race and insurance type on health care utilization and outcomes in patients treated with CAR-T for aggressive B-NHL...
March 26, 2024: Blood Advances
https://read.qxmd.com/read/38524554/association-of-padi2-and-padi4-polymorphisms-in-covid-19-host-severity-and-non-survival
#9
JOURNAL ARTICLE
Ilse Adriana Gutiérrez-Pérez, Ivette Buendía-Roldán, Oscar Zaragoza-García, Gloria Pérez-Rubio, José Rafael Villafan-Bernal, Leslie Chávez-Galán, Isela Parra-Rojas, Rafael de Jesús Hernández-Zenteno, Ingrid Fricke-Galindo, Natividad Castro-Alarcón, Brandon Bautista-Becerril, Ramcés Falfán-Valencia, Iris Paola Guzmán-Guzmán
BACKGROUND: Enzymes of the peptidylarginine deiminase family (PADs) play a relevant role in the pathogenesis of COVID-19. However, the association of single nucleotide polymorphisms (SNPs) in their genes with COVID-19 severity and death is unknown. METHODOLOGY: We included 1045 patients who were diagnosed with COVID-19 between October 2020 and December 2021. All subjects were genotyped for PADI2 (rs1005753 and rs2235926) and PADI4 (rs11203366, rs11203367, and rs874881) SNPs by TaqMan assays and their associations with disease severity, death, and inflammatory biomarkers were evaluated...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38523827/pediatric-non-hodgkin-lymphoma-as-a-rare-cause-of-spinal-cord-injury-when-lymphoma-hides-in-the-canal
#10
Daniele Zama, Egidio Candela, Gennaro Pagano, Francesco Venturelli, Fraia Melchionda, Francesco Toni, Mino Zucchelli, Andrea Pession
KEY CLINICAL MESSAGE: Spinal cord compression from non-Hodgkin lymphoma (NHL) should be considered as a potential diagnosis in cases of acute signs of myelopathy in pediatric patients. ABSTRACT: Spinal cord compression in pediatric non-Hodgkin lymphoma (NHL) is a rare presentation with potential diagnostic challenges. We report on two pediatric patients with NHL who exhibited myelopathy signs as initial presentation. Considering NHL as a differential diagnosis in pediatric patients presenting with spinal cord compression is crucial for optimizing the outcome of these patients...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38519055/molecular-assessment-of-intratumoral-immune-cell-subsets-and-potential-mechanisms-of-resistance-to-odronextamab-a-cd20%C3%A3-cd3-bispecific-antibody-in-patients-with-relapsed-refractory-b-cell-non-hodgkin-lymphoma
#11
JOURNAL ARTICLE
Jurriaan Brouwer-Visser, Nathalie Fiaschi, Raquel P Deering, Kamil J Cygan, Darius Scott, Se Jeong, Lauren Boucher, Namita T Gupta, Suraj Gupta, Christina Adler, Max S Topp, Rajat Bannerji, Johannes Duell, Ranjana H Advani, Dina M Flink, Aafia Chaudhry, Gavin Thurston, Srikanth R Ambati, Vladimir Jankovic
BACKGROUND: Patients with relapsed/refractory B-cell non-Hodgkin lymphoma (R/R B-NHL) have a significant need for effective treatment options. Odronextamab is an Fc-silenced, human, CD20×CD3 bispecific antibody that targets CD20-expressing cells via T-cell-mediated cytotoxicity independent of T-cell/major histocompatibility complex interaction. Phase I results in patients with R/R B-NHL demonstrated that odronextamab monotherapy could achieve deep and durable responses with a generally manageable safety profile (ELM-1; NCT02290951)...
March 21, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38510380/habituation-disorders-in-auditory-middle-latency-response-of-persistent-postural-perceptual-dizziness-patients
#12
JOURNAL ARTICLE
Toshihisa Murofushi, Fumiyuki Goto, Munetaka Ushio
OBJECTIVES: To study habituation disorders in auditory middle latency response (AMLR) to repetitive stimuli of persistent postural-perceptual dizziness (PPPD) patients. SUBJECTS: Twenty-eight PPPD (10 men and 18 women, mean 59.5 years of age, 26-81 years of age) were enrolled. For comparison, data of 13 definite vestibular migraine (VM) patients (3 men, 10 women, mean age 45.5), 13 definite unilateral Meniere's disease (MD) patients (2 men, 11 women, mean age 50...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38508620/rituximab-combined-anthracycline-free-chemotherapy-in-newly-diagnosed-paediatric-and-adolescent-patients-with-non-high-risk-aggressive-mature-b-cell-lymphoma-protocol-for-a-single-arm-open-label-multicentre-phase-ii-study-the-japan-children-s-cancer-group-multicentre
#13
JOURNAL ARTICLE
Masahiro Sekimizu, Reiji Fukano, Yuhki Koga, Tetsuo Mitsui, Naoto Fujita, Takeshi Mori, Daiki Hori, Makito Tanaka, Kentaro Ohki, Hideto Iwafuchi, Atsuko Nakazawa, Tetsuya Mori, Ryoji Kobayashi, Hiroya Hashimoto, Akiko M Saito, Michi Kamei
INTRODUCTION: Children and adolescents with mature B cell non-Hodgkin lymphoma (B-NHL) are treated with short-intensive chemotherapy. The burden of short-term and long-term toxicity is highly relative to its high cure rate in good-risk patients. Although the addition of rituximab to standard lymphome Malin B (LMB) chemotherapy markedly prolongs event-free survival and overall survival in high-risk patients, the benefit of rituximab in good-risk patients remains to be elucidated. This clinical trial will examine whether the addition of rituximab eliminates anthracyclines in good-risk patients without compromising treatment outcomes...
March 19, 2024: BMJ Open
https://read.qxmd.com/read/38506403/assessment-of-bone-marrow-involvement-in-b-cell-non-hodgkin-lymphoma-using-immunoglobulin-gene-rearrangement-analysis-with-next-generation-sequencing
#14
JOURNAL ARTICLE
Min Ji Jeon, Eun Sang Yu, Dae Sik Kim, Chul Won Choi, Ha Nui Kim, Jung Ah Kwon, Soo-Young Yoon, Jung Yoon
BACKGROUND: Assessment of bone marrow involvement (BMI) in non-Hodgkin lymphoma (NHL) is crucial for determining patient prognosis and treatment strategy. We assessed the prognostic value of next-generation sequencing (NGS)-based immunoglobulin (Ig) gene clonality analysis as an ancillary test for BMI evaluation in NHL. METHODS: A retrospective cohort of 124 patients newly diagnosed with B-cell NHL between 2019 and 2022 was included. NGS-based Ig clonality analysis was conducted using LymphoTrak IGH FR1 Assay and IGK Assay (Invivoscribe Technologies, San Diego, CA, USA) on BM aspirate samples, and the results were compared with those of histopathological BMI (hBMI)...
March 20, 2024: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/38496168/orthopedic-team-surgeons-in-major-professional-sports-an-analysis-of-affiliation-with-the-top-10-sports-medicine-fellowship-programs-and-implications-for-leadership-and-diversity
#15
JOURNAL ARTICLE
Robert Wood, Jorge Perera, Jacqueline Krumrey, Christopher McCrum
This paper examines the correlation between orthopedic team surgeons in major professional sports and their affiliation with the top 10 sports medicine fellowship programs. With a growing trend in post-residency fellowship training, particularly in sports medicine, the study focuses on the implications of fellowship program choice for aspiring major professional sports team physicians. By analyzing data from Major League Baseball (MLB), the National Basketball Association (NBA), the National Football League (NFL), and the National Hockey League (NHL), the research reveals that 61 of 124 (49...
February 2024: Curēus
https://read.qxmd.com/read/38487720/case-report-from-sequence-to-solution-tailoring-treatment-for-transformed-follicular-lymphoma-dlbcl-through-next-generation-sequencing-study
#16
Antonin Bouroumeau, Sarah Perdikis-Prati, Noémie Lang
Immune checkpoint blockade (ICB) has indeed transformed the outlook for many advanced-stage solid tumors, yet its effectiveness in hematological malignancies has been particularly limited, with success predominantly demonstrated in classical Hodgkin lymphoma (cHL) and immune-privilege subtypes of non-Hodgkin lymphoma (NHL). In this report, we present an impactful case of a 71-year-old man grappling with refractory follicular lymphoma (rFL) that had progressed to a high-grade lymphoma, leaving no conventional treatment options on the table...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38477498/global-burden-risk-factors-and-trends-of-non-hodgkin-lymphoma-a-worldwide-analysis-of-cancer-registries
#17
JOURNAL ARTICLE
Junjie Huang, Sze Chai Chan, Veeleah Lok, Lin Zhang, Don Eliseo Lucero-Prisno, Wanghong Xu, Zhi-Jie Zheng, Edmar Elcarte, Mellissa Withers, Martin C S Wong
BACKGROUND: Non-Hodgkin lymphoma (NHL) accounts for 90% of all malignant lymphomas. This study aimed to evaluate the global incidence, mortality, associated risk factors, and temporal trends of NHL by sex, age, and country. METHODS: Data from 185 countries globally were used for analysis. NHL incidence and mortality were collected via the GLOBOCAN (2020), CI5 series I-X, WHO mortality database, the Nordic Cancer Registries, and the SEER Program. The WHO Global Health Observatory provided country-level, age-standardized prevalence of lifestyle and metabolic risk factors...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38473919/unlocking-predictive-power-quantitative-assessment-of-car-t-expansion-with-digital-droplet-polymerase-chain-reaction-ddpcr
#18
JOURNAL ARTICLE
Eugenio Galli, Marcello Viscovo, Federica Fosso, Ilaria Pansini, Giacomo Di Cesare, Camilla Iacovelli, Elena Maiolo, Federica Sorà, Stefan Hohaus, Simona Sica, Silvia Bellesi, Patrizia Chiusolo
Flow cytometry (FCM) and quantitative PCR (qPCR) are conventional methods for assessing CAR-T expansion, while digital droplet PCR (ddPCR) is emerging as a promising alternative. We monitored CAR-T transcript expansion in 40 B-NHL patients post-infusion of CAR-T products (axi-cel; tisa-cel; and brexu-cel) with both His-Tag FCM and ddPCR techniques. Sensitivity and predictive capacity for efficacy and safety outcomes of ddPCR were analyzed and compared with FCM. A significant correlation between CAR-T counts determined by FCM and CAR transcripts assessed by ddPCR ( p < 0...
February 26, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38470973/g-csf%C3%A2-%C3%A2-plerixafor-versus-g-csf-alone-mobilized-hematopoietic-stem-cells-in-patients-with-multiple-myeloma-and-lymphoma-a-systematic-review-and-meta-analysis
#19
JOURNAL ARTICLE
Yuyao Li, Xia Qiu, Yupeng Lei, Ruixi Zhou
AIM: The combination of granulocyte-colony stimulating factor (G-CSF) and plerixafor is one of the approaches for hematopoietic stem cell mobilization in patients with multiple myeloma (MM), non-Hodgkin's lymphoma (NHL), and Hodgkin's lymphoma (HL). This systematic review and meta-analysis aimed to determine the ability of G-CSF + plerixafor to mobilize peripheral blood (PB) CD34+ cells and examine its safety profile. METHODS: We performed a database search using the terms 'granulocyte colony stimulating factor', 'G-CSF', 'AMD3100', and 'plerixafor', published up to May 1, 2023...
December 2024: Annals of Medicine
https://read.qxmd.com/read/38468555/childhood-and-adolescent-relapsed-refractory-aggressive-b-cell-lymphomas-with-t-8-14-and-bcl2-expression-burkitt-lymphoma-versus-diffuse-large-b-cell-lymphoma-a-diagnostic-challenge
#20
JOURNAL ARTICLE
Fouad El Dana, Sofia Alexandra Garces Narvaez, Nader K El-Mallawany, Jennifer E Agrusa, ZoAnn E Dreyer, Andrea N Marcogliese, Mohamed Tarek Elghetany, Jyotinder N Punia, Chi Young Ok, Keyur P Patel, Dolores H Lopez-Terrada, Kevin E Fisher, Choladda V Curry
We present 2 diagnostically challenging cases of pediatric/adolescent relapsed/refractory aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) within the spectrum of Burkitt lymphoma and diffuse large B-cell lymphoma and illustrate the different therapeutic regimens that are employed for pediatric and adult cancer centers. Both cases displayed varying-sized lymphoma cells with occasional single prominent nucleoli and heterogeneous BCL2 expression. Cytogenetics revealed complex karyotypes with t(8:14)(q24.2;q32) and IGH::MYC rearrangement by FISH...
March 11, 2024: Pediatric and Developmental Pathology
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