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Metabolic stress

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https://www.readbyqxmd.com/read/28324842/phenotypical-physiological-and-biochemical-analyses-provide-insight-into-selenium-induced-phytotoxicity-in-rice-plants
#1
Mohammad Golam Mostofa, Mohammad Anwar Hossain, Md Nurealam Siddiqui, Masayuki Fujita, Lam-Son Phan Tran
The present study investigated the phenotypical, physiological and biochemical changes of rice plants exposed to high selenium (Se) concentrations to gain an insight into Se-induced phytotoxicity. Results showed that exposure of rice plants to excessive Se resulted in growth retardation and biomass reduction in connection with the decreased levels of chlorophyll, carotenoids and soluble proteins. The reduced water status and an associated increase in sugar and proline levels indicated Se-induced osmotic stress in rice plants...
March 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28324838/influence-of-multi-walled-carbon-nanotubes-on-the-effects-of-roxithromycin-in-crucian-carp-carassius-auratus-in-the-presence-of-natural-organic-matter
#2
Zhenhua Yan, Guanghua Lu, Hongwei Sun, Binni Ma
Carbon nanotubes are increasingly entering the aquatic environment and may interact with other co-existing contaminants, such as antibiotics. However, whether these interactions may affect their bioavailability in aquatic organisms is the subject of considerable debate. The primary objective of this study was to assess the risks arising from the coexistence of roxithromycin (ROX) and multi-walled carbon nanotubes (MWCNTs) in waters containing natural organic matter (NOM), focusing on the distribution and bioaccumulation of ROX in crucian carp (Carassius auratus), and the related biochemical status...
March 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28324701/stress-reactivity-and-its-effects-on-subsequent-food-intake-in-depressed-and-healthy-women-with-and-without-adverse-childhood-experiences
#3
Katja Wingenfeld, Linn K Kuehl, Anita Boeker, Katharina Schultebraucks, Kristin Ritter, Julian Hellmann-Regen, Christian Otte, Carsten Spitzer
BACKGROUND: Adverse childhood experiences (ACE) increase the risk to develop major depressive disorder (MDD) and obesity or metabolic syndrome in adulthood. In addition, ACE may be associated with an exaggerated endocrine response to stress, which, in turn, may lead to enhanced food intake resulting in obesity and metabolic problems. METHODS: We systematically examined the stress response and consecutive food intake in 32 women with MDD and ACE as determined by a clinical interview (Early Trauma Inventory), 52 women with MDD without ACE, 22 women with ACE but no current or lifetime MDD and 37 healthy women without either MDD or ACE...
March 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28324506/induction-of-site-specific-oxidative-damage-at-telomeres-by-killerred-fused-shelretin-proteins
#4
Rong Tan, Li Lan
Chronic oxidative stress is the major endogenous metabolic stress and contributes directly to telomere shortening and senescence. Understanding the dysfunction of telomeres under oxidative stress will greatly facilitate healthy aging and advance the treatment of aging-related diseases. Here, we describe the KR-TEL (KillerRed induced DNA damage at telomeres) system that induces site-specific oxidative damage at telomeres. We have developed the KR-TEL system by fusing killerred with the shelterin component TRF1 (KR-TRF1) or other shelterin proteins...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28324269/metformin-sensitizes-triple-negative-breast-cancer-to-proapoptotic-trail-receptor-agonists-by-suppressing-xiap-expression
#5
Elena Strekalova, Dmitry Malin, Harisha Rajanala, Vincent L Cryns
PURPOSE: Despite robust antitumor activity in diverse preclinical models, TNF-related apoptosis-inducing ligand (TRAIL) receptor agonists have not demonstrated efficacy in clinical trials, underscoring the need to identify agents that enhance their activity. We postulated that the metabolic stress induced by the diabetes drug metformin would sensitize breast cancer cells to TRAIL receptor agonists. METHODS: Human triple (estrogen receptor, progesterone receptor, and HER2)-negative breast cancer (TNBC) cell lines were treated with TRAIL receptor agonists (monoclonal antibodies or TRAIL peptide), metformin, or the combination...
March 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28324190/exogenous-application-of-urea-and-a-urease-inhibitor-improves-drought-stress-tolerance-in-maize-zea-mays-l
#6
Wei Gou, Pufan Zheng, Li Tian, Mei Gao, Lixin Zhang, Nudrat Aisha Akram, Muhammad Ashraf
Drought is believed to cause many metabolic changes which affect plant growth and development. However, it might be mitigated by various inorganic substances, such as nitrogen. Thus, the study was carried out to investigate the effect of foliar-applied urea with or without urease inhibitor N-(n-butyl) thiophosphoric triamide (NBPT) on a maize cultivar under drought stress simulated by 15% (w/v) polyethylene glycol 6000. Foliar-applied urea resulted in a significant increase in plant dry weight, relative water content, and photosynthetic pigments under water stress condition...
March 21, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28324168/the-effect-of-eccentric-exercise-with-blood-flow-restriction-on-neuromuscular-activation-microvascular-oxygenation-and-the-repeated-bout-effect
#7
Jakob D Lauver, Trent E Cayot, Timothy Rotarius, Barry W Scheuermann
PURPOSE: To examine the effect of low-intensity eccentric contractions with and without blood flow restriction (BFR) on microvascular oxygenation, neuromuscular activation, and the repeated bout effect (RBE). METHODS: Participants were randomly assigned to either low-intensity (LI), low-intensity with BFR (LI-BFR), or a control (CON) group. Participants in LI and LI-BFR performed a preconditioning bout of low-intensity eccentric exercise prior to about of maximal eccentric exercise...
March 21, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28324165/lipid-phenol-and-carotenoid-changes-in-bianca-grapevine-leaves-after-mechanical-wounding-a-case-study
#8
Giulia Chitarrini, Luca Zulini, Domenico Masuero, Urska Vrhovsek
Metabolic changes can occur in plants in response to abiotic stress. Extensive use of leaf discs (mechanical wounding) in studies regarding the effect on the biochemical response of the grapevine to different types of biotic stress makes it necessary to understand metabolic perturbation after injury. In this study, we investigate how mechanical wounding can affect the metabolism of grapevine leaf tissue using Bianca variety as case study. Two sizes of leaf discs (1.1 and 2.8 cm in diameter) were excised from leaves, and phenol, lipid and carotenoid perturbation were investigated 0, 6, 12, 24, 48, 96 and 120 h post cutting...
March 21, 2017: Protoplasma
https://www.readbyqxmd.com/read/28323978/assisted-reproductive-technologies-predispose-to-insulin-resistance-and-obesity-in-male-mice-challenged-with-a-high-fat-diet
#9
David Cerny, Claudio Sartori, Stefano F Rimoldi, Théo Meister, Rodrigo Soria, Elisa Bouillet, Urs Scherrer, Emrush Rexhaj
ART alters glucose homeostasis in mice and humans, but the underlying mechanisms are incompletely understood. ART induces endothelial dysfunction and arterial hypertension by epigenetic alteration of the eNOS gene. In eNOS deficient mice, insulin resistance is related to impaired insulin stimulation of muscle blood flow and substrate delivery and defective intrinsic skeletal muscle glucose uptake. We, therefore, assessed glucose tolerance, insulin sensitivity (euglycemic clamp), insulin stimulation of muscle blood flow in vivo and muscle glucose uptake in vitro in male ART and control mice fed a normal chow (NC) or challenged with a high fat diet (HFD) during 8 weeks...
February 8, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323970/obesity-modulates-inflammation-and-lipid-metabolism-oocyte-gene-expression-a-single-cell-transcriptome-perspective
#10
Meghan L Ruebel, Matthew Cotter, Clark R Sims, Dean M Moutos, Thomas M Badger, Mario A Cleves, Kartik Shankar, Aline Andres
Context: It is hypothesized that obesity adversely affects the ovarian environment which can disrupt oocyte maturation and may further impact embryonic development. Objective: This study aimed to compare oocyte gene expression profiles and follicular fluid (FF) content from overweight/obese (OW) women and normal weight (NW) women who were undergoing fertility treatments. Design: Using single cell transcriptomic analyses, we investigated oocyte gene expression using RNA-seq...
March 15, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323516/does-normobaric-hyperoxia-cause-oxidative-stress-in-the-injured-brain-a-microdialysis-study-using-8-iso-pgf2%C3%AE-as-a-biomarker
#11
Marian Vidal-Jorge, Angela Sánchez-Guerrero, Gemma Mur-Bonet, Lidia Castro, Andreea Rădoi, Marilyn Riveiro, Natividad Fernández-Prado, Jacinto Baena, Maria A Poca, Juan Sahuquillo
Significant controversy exists regarding the potential clinical benefit of normobaric hyperoxia therapy (NBO) in patients with traumatic brain injury (TBI). This study consisted of two aims: 1) to assess whether NBO improves brain oxygenation and metabolism and 2) to determine whether this therapy may increase the risk of oxidative stress (OxS), using 8-iso-PGF2α as a biomarker. Thirty-one patients with a median admission Glasgow Coma Scale score of 4 (min: 3, max: 12) were monitored with cerebral microdialysis and brain tissue oxygen sensors and treated with FiO2 of 1...
March 21, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28320086/antifibrotic-effect-of-diethylcarbamazine-combined-with-hesperidin-against-ethanol-induced-liver-fibrosis-in-rats
#12
Alaa El-Din El-Sayed El-Sisi, Samia Salim Sokar, Abdelhadi Mohamed Shebl, Dina Zakaria Mohamed
Chronic alcohol consumption leads to extracellular matrix hyperplasia and liver fibrosis with a great role of hepatic stellate cell (HSC) activation in this process. The present study was designed to investigate the possible protective effects of diethylcarbamazine (DEC) (50mg/kg, acting as an anti-inflammatory drug, interferes with the arachidonic acid metabolism) when administrated in combination with hesperidin (HDN) (200mg/kg, a flavanone glycoside with potent antioxidant and anti-inflammatory activities) against alcoholic liver fibrosis in wistar rats compared to silymarin (Sil) (100mg/kg)...
March 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28319895/impact-of-high-cholesterol-and-endoplasmic-reticulum-stress-on-metabolic-diseases-an-updated-mini-review
#13
REVIEW
Erdi Sozen, Nesrin Kartal Ozer
Endoplasmic reticulum (ER) is the major site of protein folding and calcium storage. Beside the role of ER in protein homeostasis, it controls the cholesterol production and lipid-membrane biosynthesis as well as surviving and cell death signaling mechanisms in the cell. It is well-documented that elevated plasma cholesterol induces adverse effects in cardiovascular diseases (CVDs), liver disorders, such as non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatosis hepatitis (NASH), and metabolic diseases which are associated with oxidative and ER stress...
March 6, 2017: Redox Biology
https://www.readbyqxmd.com/read/28319890/one-year-follow-up-of-clinical-metabolic-and-oxidative-stress-profile-of-morbid-obese-patients-after-laparoscopic-sleeve-gastrectomy-8-oxo-dg-as-a-clinical-marker
#14
Lidia Monzo-Beltran, Antonio Vazquez-Tarragón, Concha Cerdà, Paula Garcia-Perez, Antonio Iradi, Carlos Sánchez, Benjamin Climent, Carmen Tormos, Antonio Vázquez-Prado, Javier Girbés, Nuria Estáñ, Sebastián Blesa, Raquel Cortés, Felipe J Chaves, Guillermo T Sáez
Obesity has grown worldwide over the last few decades. In its different degrees, obesity is accompanied by many clinical and biochemical alterations reflecting the pathological condition of various body tissues. Among the mechanisms underlying the pathogenesis of obesity and associated complications, oxidative stress (OS) may be playing an important role. In the present study, we have characterized at systemic level the degree of OS status in a group of morbid obese patients (BMI>40kg/m(2)) at basal sate and its modulation during one year after bariatric surgery using the laparoscopic sleeve gastrectomy (LSG) technique...
February 14, 2017: Redox Biology
https://www.readbyqxmd.com/read/28319745/characteristics-and-proteomic-analysis-of-pyrene-degradation-by-brevibacillus-brevis-in-liquid-medium
#15
Kun Wei, Hua Yin, Hui Peng, Zehua Liu, Guining Lu, Zhi Dang
Polycyclic aromatic hydrocarbons (PAHs) are widely spread in various ecosystems and are of great concern due to their potential toxicity, mutagenicity and carcinogenicity. Bioremediation has been proposed as an effective approach to remove PAHs. In this study, the physiological responses and proteome of Brevibacillus brevis under exposure to pyrene, a four-ring compound from PAHs family, were investigated. The changes of cell viability of B. brevis were observed during the degradation of pyrene by means of flow cytometry...
March 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28319671/amelioration-of-oxidative-stress-by-dietary-fenugreek-trigonella-foenum-graecum-l-seeds-is-potentiated-by-onion-allium-cepa-l-in-streptozotocin-induced-diabetic-rats
#16
Seetur R Pradeep, Krishnapura Srinivasan
Oxidative stress has a crucial role in the progression of diabetes and its complications. Soluble fibre-rich fenugreek seeds (Trigonella foenum-graecum L.) are understood to have a beneficial effect in the management of diabetes. Previously, we have shown that the amelioration of diabetic hyperglycemia and related metabolic abnormalities was potentiated by onion (Allium cepa L.) in experimental rats. The present study evaluated the additive beneficial effect of dietary fenugreek seeds (10%) and onion (3%) on oxidative stress in diabetic rats...
March 20, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28319140/role-of-muscle-il-6-in-gender-specific-metabolism-in-mice
#17
Amalia Molinero, Antonio Fernandez-Perez, Aina Mogas, Mercedes Giralt, Gemma Comes, Olaya Fernandez-Gayol, Mario Vallejo, Juan Hidalgo
The aim of the present work was to further explore the physiological roles of muscle-derived IL-6. Adult-floxed and conditional skeletal muscle IL-6 knock out male and female mice were used to study energy expenditure (indirect calorimetry at rest and during treadmill exercise, and body temperature cycle during the light phase) and energy intake (response to fast/refeeding). We also evaluated the responses to leptin and the activity of the insulin signalling pathway in skeletal muscle and liver by phosphorylation of Akt at Ser 473...
2017: PloS One
https://www.readbyqxmd.com/read/28318016/the-transporter-synpam71-is-located-in-the-plasma-membrane-and-thylakoids-and-mediates-manganese-tolerance-in-synechocystis-pcc6803
#18
Chiara Gandini, Sidsel Birkelund Schmidt, Søren Husted, Anja Schneider, Dario Leister
Manganese (Mn) is an essential constituent of photosystem II (PSII) and therefore indispensable for oxygenic photosynthesis. Very little is known about how Mn is transported, delivered and retained in photosynthetic cells. Recently, the thylakoid-localized transporter PAM71 has been linked to chloroplast Mn homeostasis in Arabidopsis thaliana. Here, we characterize the function of its homolog in Synechocystis (SynPAM71). We used a loss-of-function line (ΔSynPAM71), wild-type (WT) cells exposed to Mn stress and strains expressing a tagged variant of SynPAM71 to characterize the role of SynPAM71 in cyanobacterial Mn homeostasis...
March 20, 2017: New Phytologist
https://www.readbyqxmd.com/read/28317844/subtle-effects-of-environmental-stress-observed-in-the-early-life-stages-of-the-common-frog-rana-temporaria
#19
Rebecca Strong, Francis L Martin, Kevin C Jones, Richard F Shore, Crispin J Halsall
Worldwide amphibian populations are declining due to habitat loss, disease and pollution. Vulnerability to environmental contaminants such as pesticides will be dependent on the species, the sensitivity of the ontogenic life stage and hence the timing of exposure and the exposure pathway. Herein we investigated the biochemical tissue 'fingerprint' in spawn and early-stage tadpoles of the Common frog, Rana temporaria, using attenuated total reflection-Fourier-transform infrared (ATR-FTIR) spectroscopy with the objective of observing differences in the biochemical constituents of the respective amphibian tissues due to varying water quality in urban and agricultural ponds...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317485/defective-insulin-signalling-mediated-by-inflammation-connects-obesity-to-alzheimer-disease-relevant-pharmacological-therapies-and-preventive-dietary-interventions
#20
Arantxa Rodriguez-Casado, Adolfo Toledano-Díaz, Adolfo Toledano
Recent evidence suggests that obesity, besides being a risk factor for cardiovascular events, also increases the risk of Alzheimer's disease. Insulin resistance is common in all cases of obesity and appears to be the linkage between both diseases. Obesity, often associated with excessive fat and sugar intake, represents a preclinical stage toward insulin resistance during which nutrition intervention is likely to have maximum effect. In this way, healthy lifestyles lifetime to prevent obesity-related modifiable risk factors such as inflammation, oxidative stress and metabolic disorders could be simultaneously beneficial for preserving cognition and controlling the Alzheimer's...
March 16, 2017: Current Alzheimer Research
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