keyword
https://read.qxmd.com/read/38018825/-an-unusual-etiology-of-acute-pancreatitis
#1
JOURNAL ARTICLE
Mouhamed Ouni, Sana Rokbani, Asma Chaouch, Henda Chahed, Hassan Bouzidi
A 54-year-old woman consulted the emergency department for abdominal pain, vomiting and fever for 5 days. A biochemical assessment was performed and showed a lipasemia higher than 5 times normal range (264 UI/L). Hyperlipasemia is in favor of acute pancreatitis. On obtaining further history, the patient reported the SARS-CoV-2 infection two weeks ago with a laboratory investigations done the same day as the positive PCR showed a normal lipasemia. The imaging findings were suggestive of early acute pancreatitis...
November 29, 2023: Annales de Biologie Clinique
https://read.qxmd.com/read/37858433/-igg4-related-disease-a-proteiform-pathology-with-frequent-chest-manifestations
#2
REVIEW
M Groh, P Habert, M Ebbo, R Muller, L Gaigne, J-Y Gaubert, N Schleinitz
INTRODUCTION: While IgG4-related disease (IgG4-RD) was initially described in the early 2000s, its polymorphic clinical manifestations were previously reported under different names ; they have in common the presence of IgG4+ oligoclonal plasma cells and fibrosis. STATE OF THE ART: Ruling out certain differential diagnoses, the diagnosis of IgG4-RD is based on a bundle of clinical, biological and histological features. Chest involvement is variable and can affect the mediastinum, bronchi, parenchyma, pleura and/or, more rarely, bones and (pericardium, aorta, coronary…) vascular structures...
October 17, 2023: Revue des Maladies Respiratoires
https://read.qxmd.com/read/37827828/dyslipidemia-the-known-unknown
#3
JOURNAL ARTICLE
Martin Šatný
Dyslipidemia (DLP) is the most important risk factor for atherosclerotic cardiovascular disease (ASCVD) and, in the context of severe hypertriglyceridemia (TG > 10 mmol/l), a risk factor for the development of acute pancreatitis. The prevalence of DLP is very high, but their control, especially among the patients at highest risk, is often inadequate. When diagnosing DLP, we should always exclude its possible secondary aetiology (e.g. DLP in the context of hypothyroidism, diabetes, ...). Based on the assessment of the overall CV risk (according to SCORE2/SCORE2-OP or according to the comorbidities of the individual), target values for blood lipids, especially LDL-cholesterol, are determined according to the risk category...
2023: Vnitr̆ní Lékar̆ství
https://read.qxmd.com/read/37664472/diabetes-mellitus-as-a-consequence-of-acute-severe-pancreatitis-unraveling-the-mystery
#4
REVIEW
Manish Manrai, Anupam K Singh, Chhagan Lal Birda, Jimil Shah, Aditya Dutta, Sanjay Kumar Bhadada, Rakesh Kochhar
The occurrence of diabetes mellitus (DM) in pancreatitis is being increasingly recognized lately. Diabetes can develop not only with chronic pancreatitis but even after the first episode of acute pancreatitis (AP). The incidence of diabetes after AP varies from 18% to 23% in 3 years and reaches up to 40% over 5 years. The exact pathogenesis of diabetes after AP is poorly understood and various mechanisms proposed include loss of islet cell mass, AP-induced autoimmunity, and alterations in the insulin incretin axis...
August 15, 2023: World Journal of Diabetes
https://read.qxmd.com/read/36858969/acute-recurrent-pancreatitis-during-3rd-trimester-of-pregnancy
#5
JOURNAL ARTICLE
Jakub Tobola, Martin Němec, Petronela Bieliková
OBJECTIVE: We present an unusual case report of a pregnant patient with recurrent attacks of acute pancreatitis due to cholecystolithiasis. CONCLUSION: Acute pancreatitis in pregnancy is a rare disease. Unlike the non-pregnant population, it is characterized by a high recurrence rate. Acute pancreatitis during pregnancy has a negative effect on both the mother and the fetus. The treatment is modified depending on the trimester of pregnancy.
2023: Ceská Gynekologie
https://read.qxmd.com/read/36543135/%C3%AE-hydroxybutyrate-inhibits-ferroptosis-mediated-pancreatic-damage-in-acute-liver-failure-through-the-increase-of-h3k9bhb
#6
JOURNAL ARTICLE
Yufan Zheng, Wenrui Sun, Cong Shan, Borui Li, Jiaying Liu, Hao Xing, Qingling Xu, Baiping Cui, Wenjia Zhu, Jia Chen, Liyan Liu, Tian Yang, Ning Sun, Xiaobo Li
Acute pancreatitis and hyperamylasemia are often seen in patients with acute liver failure (ALF). However, the underlying mechanisms remain elusive. This study describes pancreatic tissue damage and exocrine dysfunction in a mouse model of major-liver-resection-induced ALF. The analysis of 1,264 clinical cases of liver failure (LF) showed that the incidence of hyperamylasemia and hyperlipasemia in patients with LF is 5.5% and 20%, respectively. Metabolomic studies indicate that glutathione (GSH)-deficiency-caused ferroptosis contributes to pancreatic damage in mouse ALF...
December 20, 2022: Cell Reports
https://read.qxmd.com/read/36382984/r%C3%A3-animation-liquidienne-et-pancr%C3%A3-atite-aigu%C3%A3-%C3%A2-point-trop-n%C3%A2-en-faut
#7
Sabine Ammann
No abstract text is available yet for this article.
November 16, 2022: Revue Médicale Suisse
https://read.qxmd.com/read/35796477/triad-of-diabetic-ketoacidosis-acute-pancreatitis-hypertriglyceridaemia-interest-of-genetic-exploration
#8
JOURNAL ARTICLE
Hugo Alarcan, Antoine Guillon, François Maillot, Delphine Collin-Chavagnac, Andres Christian, Hélène Blasco, Eric Piver
A 16-year-old child with no medical history was admitted to the hospital emergency for abdominal pain associated with polyuria-polydipsia and weight loss (baseline BMI: 25,4 kg/m2). Diagnosis of severe ketoacidosis was quickly raised regarding major metabolic acidosis, high ketonemia and glycemia. Acute pancreatitis was then diagnosed according to a plasmatic lipase more than tenfold normal values associated with a severe hypertriglyceridemia superior to 100 mmol/L. The triad composed of diabetic ketoacidosis-acute pancreatitis-hypertriglyceridemia is rarely found in childhood and can have deleterious consequences...
June 30, 2022: Annales de Biologie Clinique
https://read.qxmd.com/read/35525785/-acute-pancreatitis-as-a-complication-of-massive-hemolysis-in-patients-on-hemodialysis-about-three-observations
#9
JOURNAL ARTICLE
Ariane Vanderick, Éric Goffin, Valentine Gillion
Haemolysis is an uncommon complication of haemodialysis which can be serious. We herein report on three patients with kidney failure who developed acute pancreatitis due to mechanical haemolysis during a haemodialysis session. We also review the current literature and discuss putative etiopathogenic mechanisms.
May 4, 2022: Néphrologie & Thérapeutique
https://read.qxmd.com/read/35317479/-postpartum-idiopathic-acute-pancreatitis-diagnostic-difficulties-case-report
#10
Abderrahmane Jallouli, Hicham Baba, Ahmed Zeroual, Mohamed Es-Said Ramraoui, Ahmed Elguazzar, Mohammed Lahkim, Ahmed El Khader, Rachid El Barni
Acute pancreatitis during the postpartum period or during pregnancy is rare. Biliary disease is the most common cause of acute pancreatitis, followed by hypertriglyceridemia. We here report the case of a 19-year-old patient with acute pancreatitis occurring 4 weeks after delivery and revealed by epigastralgia radiating to the back, lipasemia more than 36 times the normal limit and etiologic investigation that gave negative results. Early diagnosis of acute pancreatitis during the postpartum period is a challenge for clinicians because it is rare and differential diagnosis includes multiple disorders...
2022: Pan African Medical Journal
https://read.qxmd.com/read/35050802/therapeutic-effect-of-rupatadine-against-l-arginine-induced-acute-pancreatitis-in-rats-role-of-inflammation
#11
JOURNAL ARTICLE
Mervat Z Mohamed, Hanaa H Mohammed, Hanaa M Khalaf
Acute pancreatitis (AP) is an abrupt inflammatory disorder causing high morbidity and mortality. As AP is an insidious medical emergency, a curative modality is required instead of a preventive measure. Thus, we investigated the possible curative effect of rupatadine on a rat model of AP. Rupatadine is a potent histamine receptor 1 (H1R) and platelet-activating factor (PAF) blocker. We used four groups of six Wistar rats as follows: the control group received vehicle; the rupatadine control group received rupatadine as 6 mg/kg orally; the AP group received l-arginine intraperitoneally, and the treatment group received rupatadine at 1, 6, and 24 h after l-arginine injection...
February 2022: Canadian Journal of Physiology and Pharmacology
https://read.qxmd.com/read/34923454/pain-syndrom-in-cases-of-patients-with-a-combination-of-chronic-pancreatitis-and-hypertension-relationships-interactions-correction
#12
JOURNAL ARTICLE
Olesya M Horlenko, Lyubomyra B Prylypko, Bohdan M Halay, Lyubov A Halay, Halyna M Beley, Fedir V Horlenko
OBJECTIVE: The aim: To identify the relationships and interactions of the pain development in cases of patients with a combination of Chronic Pancreatits and Arterial Hypertension, with the next correction. PATIENTS AND METHODS: Materials and methods: We have conducted a comprehensive examination of 102 patients with a diagnosis of Chronic Pancreatitis in combination with stage II Arterial Hypertension during 2018-2020. The investigative contingent was divided by two study groups which depended from the treatment regimen...
2021: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/34920904/-multivisceral-pancratic-cytosteatonecrosis-found-at-autopsy
#13
JOURNAL ARTICLE
Gabriel Nougnignon Comlan Deguenonvo, Ibou Thiam
INTRODUCTION: Pancreatic cytosteatonecrosis is a rare condition associated with various pancreatic diseases such as acute or chronic pancreatitis and pancreatic cancer. We report a case of pancreatic cytosteatonecrosis discovered at autopsy. OBSERVATION: This is a young man, 29 years old, alcoholic, non-smoker, who consulted for abdominal pain, vomiting, fever (38°). Renal ultrasound showed signs of acute renal failure, with severe anemia at 6g/dl and hyperleukocytosis...
October 2022: Annales de Pathologie
https://read.qxmd.com/read/34793682/trimethylamine-n-oxide-promotes-hyperlipidemia-acute-pancreatitis-via-inflammatory-response
#14
JOURNAL ARTICLE
Guodong Yang, Xiaoying Zhang
Trimethylamine N-oxide (TMAO), a metabolite of gut microbiota, is involved in the regulation of lipid metabolism and inflammatory response; however, the role of TMAO in hyperlipidemia acute pancreatitis (HAP) is not clear. In this study, HAP mice were used as an animal model to explore the effects and possible mechanism of TMAO on HAP, which may provide new ideas for the treatment of HAP. Results found that the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol, nonestesterified fatty acid, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, α-amylase, TMAO, and flavin-containing monooxygenase 3 were significantly increased, the levels of high-density lipoprotein cholesterol and insulin were significantly decreased, and there was an obvious pancreatic injury and inflammatory response in the model group...
November 18, 2021: Canadian Journal of Physiology and Pharmacology
https://read.qxmd.com/read/34509317/-epigastric-pain
#15
JOURNAL ARTICLE
C Lambert, T Mahévas, D Gobert, M Bravetti, A Radzik, A Poujol-Robert, E Ghrenassia, O Fain
No abstract text is available yet for this article.
April 2022: La Revue de Médecine Interne
https://read.qxmd.com/read/34357718/-acute-pancreatitis-induced-by-metastases-from-small-cell-pulmonary-cancer
#16
T Laissus, D Lacremans, O Golinval
Although metastatic lesions associated with small cell lung cancer (SCLC) are rare in the pancreas, metastatic-induced acute pancreatitis from the same cancer is even more so. We discuss the clinical case of a 67-year-old patient with SCLC, diagnosed for 21 months and stable for 3 months, presenting in the emergency department with transfixing epigastric pain. The radiological study reveals two large masses in the pancreas as well as multiple peripancreatic adenopathies. They are confirmed as metastases of the SCLC...
July 2021: Revue Médicale de Liège
https://read.qxmd.com/read/33676780/-management-of-acute-pancreatitis-a-literature-review
#17
REVIEW
A Guyot, J B Lequeu, O Dransart-Rayé, O Chevallier, M Nguyen, P E Charles, T Mouillot, S Manfredi, T Degand
The management of acute pancreatitis is now fairly codified, with specific recommendations developed by expert groups. These recommendations deal in particular with the minimum initial assessment, recognized severity scores, initial medical management with hyperhydration, preventive anticoagulation, early refeeding, delays in imaging and management of complications. In this work, we have tried to bring together the various recommendations, articles and studies dealing with this subject, based more particularly on European recommendations, in order to guide the management of acute pancreatitis in current practice...
September 2021: La Revue de Médecine Interne
https://read.qxmd.com/read/33318098/association-entre-un-taux-ind%C3%A3-tectable-de-bicarbonate-s%C3%A3-rique-et-une-pancr%C3%A3-atite-due-%C3%A3-une-hypertriglyc%C3%A3-rid%C3%A3-mie
#18
JOURNAL ARTICLE
Nicole L Veltri, Michael Chan, Sara Awad
No abstract text is available yet for this article.
December 14, 2020: Canadian Medical Association Journal: CMAJ
https://read.qxmd.com/read/33207906/an-extremely-uncommon-complication-of-acute-pancreatitis-spontaneous-pancreatic-cutaneous-fistula
#19
JOURNAL ARTICLE
Paula Fernández Álvarez, Belén Maldonado Pérez, Ángel Caunedo Álvarez
We report the case of a 67-year-old male who was referred to our hospital due to severe abdominal pain and fever. His past medical history included a total gastrectomy surgery for stomach cancer. Abdominal examination showed intense pain on deep palpation in the epigastric region. Laboratory test revealed elevated C-reactive protein (235 mg/l) and amylase (1,789 U/l). Computerized tomography reported a pancreatic collection with the presence of air bubbles inside and areas of necrotic pancreatic parenchyma.
March 2021: Revista Española de Enfermedades Digestivas
https://read.qxmd.com/read/31414732/effect-of-pi3k-pkb-signal-pathway-inhibitor-wortmannin-pretreatment-on-intestinal-barrier-function-in-severe-acute-pancreatitic-rats
#20
JOURNAL ARTICLE
Qinqing Tang, Hengyi Wang, Xingyu Wang, Maoyong Fang, Hong Zhang
BACKGROUND: It is well-known that severe acute pancreatitis (SAP) due to infection is mainly caused by intestinal bacterial translocation. The intestinal barrier is tasked with preventing intestinal pathogenic bacteria and toxins from reaching the parenteral tissues through the intestinal wall. Therefore, maintaining intestinal barrier function may be the key to preventing damage from acute pancreatitis (AP). The phosphatidylinositol 3-kinase/protein kinase B pathway (PI3K/PKB) plays a role in AP...
August 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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