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Chondroitin

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https://www.readbyqxmd.com/read/28339999/bone-curvature-changes-can-predict-the-impact-of-treatment-on-cartilage-volume-loss-in-knee-osteoarthritis-data-from-a-2-year-clinical-trial
#1
Jean-Pierre Raynauld, Jean-Pierre Pelletier, Philippe Delorme, Pierre Dodin, François Abram, Johanne Martel-Pelletier
Objectives.: Knee bone curvature assessed by MRI was associated with OA cartilage loss. A recent knee OA trial demonstrated the superiority of chondroitin sulfate over celecoxib (comparator) at reducing cartilage volume loss (CVL) in the medial compartment (condyle). The main objectives were to identify which baseline bone curvature regions of interest (BCROI) best associated with CVL and investigate whether baseline BCROI and 2-year change are correlated with the protective effect of chondroitin sulphate on CVL...
March 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28335265/green-synthesis-of-hierarchically-structured-silver-polymer-nanocomposites-with-antibacterial-activity
#2
María Jesús Hortigüela, Luis Yuste, Fernando Rojo, Inmaculada Aranaz
The in situ formation of silver nanoparticles (AgNPs) aided by chondroitin sulfate and the preparation of a hierarchically structured silver-polymer nanocomposite with antimicrobial activity is shown. Green synthesis of AgNPs is carried out by thermal treatment (80 and 90 °C) or UV irradiation of a chondroitin sulfate solution containing AgNO₃ without using any further reducing agents or stabilizers. Best control of the AgNPs size and polydispersity was achieved by UV irradiation. The ice-segregation-induced self-assembly (ISISA) process, in which the polymer solution containing the AgNPs is frozen unidirectionally, and successively freeze-drying were employed to produce the chondroitin sulfate 3D scaffolds...
July 25, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28333845/changes-in-the-extracellular-matrix-are-associated-with-the-development-of-serous-tubal-intraepithelial-carcinoma-into-high-grade-serous-carcinoma
#3
Sophieke C H A van der Steen, Johan Bulten, Koen K Van de Vijver, Toin H van Kuppevelt, Leon F A G Massuger
OBJECTIVE: The identification of a marker for early progression of preinvasive lesions into invasive pelvic high-grade serous carcinoma (HGSC) may provide novel handles for innovative screening and prevention strategies. The interplay between cancer cells and the extracellular matrix (ECM) is one of the main principles in cancer development and growth, but has been largely neglected in preinvasive lesions. This is the first study addressing the involvement of the ECM in the "step-by-step" transition of normal fallopian tube epithelium into preinvasive lesions, and eventually the progression of preinvasive lesions into invasive HGSC...
March 23, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28331832/glucosamine-and-chondroitin-use-in-canines-for-osteoarthritis-a-review
#4
REVIEW
Angel Bhathal, Meredith Spryszak, Christopher Louizos, Grace Frankel
Osteoarthritis is a slowly progressive and debilitating disease that affects canines of all breeds. Pain and decreased mobility resulting from osteoarthritis often have a negative impact on the affected canine's quality of life, level of comfort, daily functioning, activity, behaviour, and client-pet companionship. Despite limited and conflicting evidence, the natural products glucosamine hydrochloride (HCl) and chondroitin sulfate are commonly recommended by veterinarians for treating osteoarthritis in dogs...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/28325683/biomimetic-scaffolds-with-three-dimensional-undulated-microtopographies
#5
Jonelle Z Yu, Emrullah Korkmaz, Monica I Berg, Philip R LeDuc, O Burak Ozdoganlar
Many human and animal tissues naturally possess three-dimensional (3D) micro-scale geometries enabling certain physiological functions. Absence of these microgeometries in engineered tissues may undermine the effectiveness of corresponding tissue repair and regeneration. This paper introduces a novel approach to create tissue scaffolds with biomimetic 3D undulated microtopographies. The mechanical micromilling technology is used for precise and reproducible fabrication of poly(methyl methacrylate) (PMMA) master molds with 3D undulated microtopographies...
February 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/28325347/two-fucosylated-chondroitin-sulfates-from-the-sea-cucumber-eupentacta-fraudatrix
#6
Nadezhda E Ustyuzhanina, Maria I Bilan, Andrey S Dmitrenok, Nikolay E Nifantiev, Anatolii I Usov
Two fucosylated chondroitin sulfates EF1 and EF2 were isolated from the sea cucumber Eupentacta fraudatrix. Separation of the polysaccharides was performed using anion-exchange chromatography on DEAE-Sephacel by elution of 0.75M and 1.0M NaCl solutions. The structures of biopolymers were determined by chemical and NMR spectroscopic methods. The backbone of EF1 was found to be composed of chondroitin sulfate A and E units in a ratio of about 1:1. The core of EF2 along with chondroitin sulfate A and E fragments contained unusual disaccharide repeating units →4)-β-d-GlcpA2S3S-(1→3)-β-d-GalpNAc6S-(1→...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28325317/distribution-of-uronic-acid-containing-polysaccharides-in-5-species-of-shellfishes
#7
Bin Liu, Haiman Liu, Chunqing Ai, Zhenjun Zhu, Chengrong Wen, Shuang Song, Beiwei Zhu
Mollusks are a rich source of uronic acid-containing polysaccharides (UACPs) possessing biological and pharmacological activities. In the present study, UACP compositions of different tissues from 5 species of edible shellfishes, namely Neverita didyma, Natica janthostomoides, Saxidomus purpurata, Cyclina sinensis, and Chlamys farreri were systemically analyzed. Totally 10 UACPs were observed, including chondroitin sulfate, heparin, an identified mannoglucuronan, 3 unknown glycosaminoglycans (GAGs, U1, U3 and U6) with hexuronic acid-hexosamine repeating units, and 4 unknown non-GAGs (U2, U4, U5 and U7) with hexuronic acid-hexose repeating units...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28325283/silencing-of-carbohydrate-sulfotransferase-15-hinders-murine-pulmonary-fibrosis-development
#8
Yoshiro Kai, Koichi Tomoda, Hiroyuki Yoneyama, Masahiro Kitabatake, Atsuhiro Nakamura, Toshihiro Ito, Masanori Yoshikawa, Hiroshi Kimura
Pulmonary fibrosis is a progressive lung disorder characterized by interstitial fibrosis, for which no effective treatments are available. Chondroitin sulfate proteoglycan (CSPG) has been shown to be a mediator, but the specific component of glycosaminoglycan chains of CSPG has not been explored. We show that chondroitin sulfate E-type (CS-E) is involved in fibrogenesis. Small interfering RNA (siRNA) targeting carbohydrate sulfotransferase 15 (CHST15) was designed to inhibit CHST15 mRNA and its product, CS-E...
March 17, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28325051/bioavailability-of-immobilized-epidermal-growth-factor-covalent-versus-noncovalent-grafting
#9
Nesrine Riahi, Frederic Murschel, Sophie Lerouge, Yves Durocher, Olivier Henry, Gregory De Crescenzo
In an effort to rationalize and optimize an antiapoptotic coating combining chondroitin sulfate (CS) and epidermal growth factor (EGF) for vascular applications, the authors here report the comparison of two grafting strategies aiming to display EGF in an oriented fashion on CS. For that purpose, the authors produced, purified, and characterized a chimeric protein corresponding to EGF that was N-terminally fused to a cysteine and a coil peptide. The chimera was covalently immobilized via its free thiol group or captured via coiled-coil interactions at the surface of a biosensor or on a chondroitin sulfate coating in multiwell plates, mimicking the coating that was previously developed by them for stent-graft surfaces...
March 21, 2017: Biointerphases
https://www.readbyqxmd.com/read/28323012/extracellular-matrix-alterations-in-the-ketamine-model-of-schizophrenia
#10
Gabriela Matuszko, Sebastiano Curreli, Rahul Kaushik, Axel Becker, Alexander Dityatev
The neural extracellular matrix (ECM) plays an important role in regulation of perisomatic GABAergic inhibition and synaptic plasticity in the hippocampus and cortex. Decreased labeling of perineuronal nets, a form of ECM predominantly associated with parvalbumin-expressing interneurons in the brain, has been observed in post-mortem studies of schizophrenia patients, specifically, in brain areas such as prefrontal cortex, entorhinal cortex, and amygdala. Moreover, glial ECM in the form of dandelion clock-like structures was reported to be altered in schizophrenia patients...
March 16, 2017: Neuroscience
https://www.readbyqxmd.com/read/28322163/geriatric-oriented-high-dose-nutraceutical-odts-formulation-and-physicomechanical-characterization
#11
Ahmed M Agiba, Sameh Abdel-Hamid, Maha Nasr, Ahmed S Geneidi
CONTEXT: Oral disintegrating tablets (ODTs) represent a better option than conventional tablets for geriatric population, owing to their fast onset of action and their better patient compliance. OBJECTIVE: Two principal therapeutic high-dose nutraceuticals; chondroitin sulphate and glucosamine were formulated into an oral disintegration tablet (ODT) intended for sublingual administration, and optimized to improve compliance and achieve rapid onset of action in osteoarthritis treatment...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28321256/biochemical-and-clinical-assessments-of-segmental-maxillary-posterior-tooth-intrusion
#12
Jintana Tasanapanont, Tanapan Wattanachai, Janya Apisariyakul, Peraphan Pothacharoen, Siriwan Ongchai, Prachya Kongtawelert, Marit Midtbø, Dhirawat Jotikasthira
Objective. To compare chondroitin sulphate (CS) levels around maxillary second premolars, first molars, and second molars between the unloaded and the loaded periods and to measure the rates of intrusion of maxillary posterior teeth during segmental posterior tooth intrusion. Materials and Methods. In this prospective clinical study, 105 teeth (from 15 patients exhibiting anterior open bite and requiring maxillary posterior tooth intrusion) were studied. Competitive ELISA was used to detect CS levels. Dental casts (during the unloaded and loaded periods) were scanned, and posterior tooth intrusion distances were measured...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28317663/mixed-polymeric-systems-new-ophthalmic-viscosurgical-device-created-by-mixing-commercially-available-devices
#13
Daniele Tognetto, Paolo Cecchini, Rossella D'Aloisio, Romano Lapasin
PURPOSE: To evaluate the rheological properties of mixtures of different commercially available ophthalmic viscosurgical devices (OVDs) containing sodium hyaluronate and chondroitin sulfate. SETTING: Eye Clinic, University of Trieste, Trieste, Italy. DESIGN: Laboratory study. METHODS: Blends were obtained combining a superviscous cohesive OVD (Healon GV [sodium hyaluronate 1%]) and a medium-viscosity dispersive OVD (Viscoat [sodium hyaluronate 3...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28316603/dose-dependent-induction-of-an-idiotypic-cascade-by-anti-glycosaminoglycan-monoclonal-antibody-in-apoe-mice-association-with-atheroprotection
#14
Roger Sarduy, Victor Brito, Adriana Castillo, Yosdel Soto, Tania Griñán, Sylvie Marleau, Ana María Vázquez
Atherosclerosis, the underlying pathology of most cardiovascular diseases, is triggered by the retention of apolipoprotein B (apoB)-containing lipoproteins in the arterial wall through electrostatic interactions with glycosaminoglycan (GAG) side chains of proteoglycans. Previously, we reported the antiatherogenic properties of the chimeric monoclonal antibody (mAb) chP3R99-LALA, which binds sulfated GAGs, inhibits low-density lipoprotein (LDL)-chondroitin sulfate (CS) association, and abrogates LDL oxidation and foam cell formation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28300032/-recurrent-urinary-tract-infections-prevention-of-recurrence-with-intravesical-instillations-of-chondroitin-sulfate-and-hyaluronic-acid
#15
Jesús Ignacio Tornero Ruiz, Gloria Martínez Gómez, José Félix Escudero Bregante, Guillermo Antonio Gómez Gómez
OBJECTIVE: The aim of our study is to demonstrate that intravesical administration of the association chondroitin sulfate (CS) and hyaluronic acid (HA), according to our treatment schedule, is a benefit for women with recurrent urinary tract infections (RUTI), not only from a clinical point of view, but also reducing recurrences. METHODS: This is a study of 28 women diagnosed with RUTI, with a positive culture, and compatible symptoms;frethey underwent treatment according to the protocol of intravesical instillations of the combination CS 2%-1 gr + HA 1...
March 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28293868/engineering-s-equi-subsp-zooepidemicus-towards-concurrent-production-of-hyaluronic-acid-and-chondroitin-biopolymers-of-biomedical-interest
#16
Donatella Cimini, Ileana Dello Iacono, Elisabetta Carlino, Rosario Finamore, Odile F Restaino, Paola Diana, Emiliano Bedini, Chiara Schiraldi
Glycosaminoglycans, such as hyaluronic acid and chondroitin sulphate, are not only more and more required as main ingredients in cosmeceutical and nutraceutical preparations, but also as active principles in medical devices and pharmaceutical products. However, while biotechnological production of hyaluronic acid is industrially established through fermentation of Streptococcus spp. and recently Bacillus subtilis, biotechnological chondroitin is not yet on the market. A non-hemolytic and hyaluronidase negative S...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28291206/-potential-for-use-of-hydroxypropyl-guar-in-tear-substitute-therapy
#17
V V Brzhesky, S Yu Golubev
Of the large number of polymers used in artificial tear formulations, natural polysaccharides - hydroxypropyl guar, sodium hyaluronate, chondroitin sulfate, dextran, etc., are gaining more and more popularity. Hydroxypropyl guar stands out through its ability to form a long-lasting structured matrix adhered to the damaged ocular surface and ensuring good wettability of the latter and regeneration of epithelial cells. At that, the viscosity of hydroxypropyl guar increases with increasing tear pH (which, in turn, correlates with the severity of xerosis) and further prolongs the moisturizing effect...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28290150/extracellular-matrix-modulation-is-driven-by-experience-dependent-plasticity-during-stroke-recovery
#18
Miriana Jlenia Quattromani, Mathilde Pruvost, Carla Guerreiro, Fredrik Backlund, Elisabet Englund, Anders Aspberg, Tomasz Jaworski, Jakob Hakon, Karsten Ruscher, Leszek Kaczmarek, Denis Vivien, Tadeusz Wieloch
Following stroke, complete cellular death in the ischemic brain area may ensue, with remaining brain areas undergoing tissue remodelling to various degrees. Experience-dependent brain plasticity exerted through an enriched environment (EE) promotes remodelling after central nervous system injury, such as stroke. Post-stroke tissue reorganization is modulated by growth inhibitory molecules differentially expressed within the ischemic hemisphere, like chondroitin sulfate proteoglycans found in perineuronal nets (PNNs)...
March 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28287848/immunomodulating-and-immunoresistance-properties-of-cancer-initiating-cells-implications-for-the-clinical-success-of-immunotherapy
#19
Cristina Maccalli, Giorgio Parmiani, Soldano Ferrone
Cancer-initiating cells (CICs) represent a relatively rare subpopulation of cells endowed with self-renewal, stemness properties, tumorigenicity in immunodeficient mice, and resistance to standard therapies as well as to immunotherapy. Here, we review the biological and immunological characteristics of CICs with special focus on the immunomodulating mechanisms they utilize to escape from immunosurveillance. The recently developed immunotherapeutic strategies have yielded remarkable clinical results in many types of tumors, indicating that indeed a patient's immune system can mount an immune response, which is effective in controlling tumor growth...
March 13, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28285569/gelatin-scaffolds-containing-partially-sulfated-cellulose-promote-mesenchymal-stem-cell-chondrogenesis
#20
Gloria Portocarrero Huang, Roseline Menezes, Richard Vincent, Willis Hammond, Louis Rizio, George Collins, Treena Livingston Arinzeh
Articular cartilage has a limited capacity to heal after damage from injury or degenerative disease. Tissue engineering constructs that more closely mimic the native cartilage microenvironment can be utilized to promote repair. Glycosaminoglycans (GAGs), a major component of the cartilage extracellular matrix, have the ability to sequester growth factors due to their level and spatial distribution of sulfate groups. This study evaluated the use of a GAG mimetic, cellulose sulfate, as a scaffolding material for cartilage tissue engineering...
March 12, 2017: Tissue Engineering. Part A
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