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https://www.readbyqxmd.com/read/29783635/glycosaminoglycans-from-a-sea-snake-lapemis-curtus-extraction-structural-characterization-and-antioxidant-activity
#1
Mingyue Bai, Wenwei Han, Xia Zhao, Qingchi Wang, Yanyun Gao, Shiming Deng
Sea snakes have wide application prospects in medicine, health food and other fields. Several novel polysaccharides were successfully obtained from the skin and the meat of a sea snake ( Lapemis curtus ). The structures of polysaccharides LSP3 and LMP3, which were extracted and purified from Lapemis curtus , were determined to be new and highly heterogenic glycosaminoglycans (GAGs) by means of FT-IR, ESI-MS/MS and NMR. LSP3 is a hybrid dermatan sulfate (DS) and composed of 48% 4-sulfated disaccharides (Di4S), 42% 6-sulfated disaccharides (Di6S) and 5% disulfated disaccharides (Di2,6S), while LMP3 is a hybrid chondroitin sulfate (CS) and composed of 70% Di4S, 20% Di6S, and 8% Di2,6S...
May 18, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29782979/chondroitin-sulfate-from-sturgeon-bone-ameliorates-pain-of-osteoarthritis-induced-by-monosodium-iodoacetate-in-rats
#2
Yingjiao Sun, Guozhuan Zhang, Qian Liu, Xudong Liu, Lei Wang, Jianfeng Wang, Lishuang Liang
Chondroitin sulfate (CS) is an important component of the extracellular matrix of cartilage and has been widely used as one of the main drugs for the treatment of joint pain-related nutraceuticals and medicines. Sturgeon bone (SB) is the main waste during deep processing of sturgeons in fishery production. The present study was evaluated the therapeutic effect of CS from SB (CSSB) on monosodium iodoacetate (MIA)-induced osteoarthritis (OA) pain and further explored the potential medicinal value of CSSB. The OA pain model was induced by intra-articular injection of MIA and then treated with CSSB...
May 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29782809/the-effects-of-normal-aging-on-regional-accumulation-of-hyaluronan-and-chondroitin-sulfate-proteoglycans-in-the-mouse-brain
#3
May J Reed, Mamatha Damodarasamy, Jasmine L Pathan, Michelle A Erickson, William A Banks, Robert B Vernon
The brain changes in volume and composition with normal aging. Cellular components of the brain are supported by an extracellular matrix (ECM) comprised largely of hyaluronan (HA) and HA-associated members of the lectican family of chondroitin sulfate proteoglycans (CSPGs). We examined regional differences in microvascular density, neuronal and glial markers, and accumulation of HA and CSPGs in mouse brains during normal aging. The cortex, hippocampus, dentate gyrus, and cerebellum of young (4 months), middle-aged (14 months), and aged (24-26 months) brains were analyzed...
May 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29779902/molecular-genetics-and-metabolism-special-edition-diagnosis-diagnosis-and-prognosis-of-mucopolysaccharidosis-iva
#4
REVIEW
Hira Peracha, Kazuki Sawamoto, Lauren Averill, Heidi Kecskemethy, Mary Theroux, Mihir Thacker, Kyoko Nagao, Christian Pizarro, William Mackenzie, Hironori Kobayashi, Seiji Yamaguchi, Yasuyuki Suzuki, Kenji Orii, Tadao Orii, Toshiyuki Fukao, Shunji Tomatsu
Mucopolysaccharidosis IVA (MPS IVA, Morquio A syndrome) is an autosomal recessive disorder caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase. Deficiency of this enzyme leads to the accumulation of specific glycosaminoglycans (GAGs), chondroitin-6-sulfate (C6S) and keratan sulfate (KS), which are mainly synthesized in the cartilage. Therefore, the substrates are stored primarily in the cartilage and its extracellular matrix (ECM), leading to a direct impact on bone development and successive systemic skeletal spondylepiphyseal dysplasia...
May 15, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29774074/placenta-specific-drug-delivery-by-trophoblast-targeted-nanoparticles-in-mice
#5
Baozhen Zhang, Lunbo Tan, Yan Yu, Baobei Wang, Zhilong Chen, Jinyu Han, Mengxia Li, Jie Chen, Tianxia Xiao, Balamurali K Ambati, Lintao Cai, Qing Yang, Nihar R Nayak, Jian Zhang, Xiujun Fan
Rationale: The availability of therapeutics to treat pregnancy complications is severely lacking, mainly due to the risk of harm to the fetus. In placental malaria, Plasmodium falciparum- infected erythrocytes (IEs) accumulate in the placenta by adhering to chondroitin sulfate A (CSA) on the surfaces of trophoblasts. Based on this principle, we have developed a method for targeted delivery of payloads to the placenta using a synthetic placental CSA-binding peptide (plCSA-BP) derived from VAR2CSA, a CSA-binding protein expressed on IEs...
2018: Theranostics
https://www.readbyqxmd.com/read/29772114/effect-of-highly-concentrated-hyaluronic-acid-chondroitin-sulfate-instillation-on-ureteral-stent-induced-discomfort-after-ureteroscopic-lithotripsy-a-multicenter-randomized-controlled-pilot-study
#6
Jung Ki Jo, Jae Heon Kim, Kyu Shik Kim, Jae Hoon Chung, Sung Yul Park, Yong Tae Kim, Hong Yong Choi, Eun-Seop Song, Bora Lee, Seung Wook Lee
OBJECTIVE: To investigate the efficacy and safety of instilling highly concentrated hyaluronic acid (HA)/chondroitin sulfate (CS) on the ureteral stent-related pain, urinary symptoms, and quality of life (QoL) of patients who underwent ureteroscopic lithotripsy for ureter stones followed by ureteral stent placement. PATIENTS AND METHODS: Eligible patients were randomly allocated to receive intravesical instillation with HA/CS or normal saline just after ureteral stent placement...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29771395/glucosamine-and-chondroitin-sulfate-what-has-been-learned-since-the-glucosamine-chondroitin-arthritis-intervention-trial
#7
Nicholas DiNubile
Glucosamine and chondroitin sulfate, alone or in combination, are used worldwide by individuals suffering from osteoarthritis pain. They are by prescription in some countries but are available as over-the-counter dietary supplements in other countries, such as the United States. The inconclusive results of the National Institutes of Health-sponsored Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) did little to clarify the efficacy of these agents. However, some newer studies have provided a better perspective on the potential benefits that they can offer...
May 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29762123/identification-of-a-critical-sulfation-in-chondroitin-that-inhibits-axonal-regeneration
#8
Craig S Pearson, Caitlin P Mencio, Amanda C Barber, Keith R Martin, Herbert M Geller
The failure of mammalian CNS neurons to regenerate their axons derives from a combination of intrinsic deficits and extrinsic factors. Following injury, chondroitin sulfate proteoglycans (CSPGs) within the glial scar inhibit axonal regeneration, an action mediated by the sulfated glycosaminoglycan (GAG) chains of CSPGs, especially those with 4-sulfated (4S) sugars. Arylsulfatase B (ARSB) selectively cleaves 4S groups from the non-reducing ends of GAG chains without disrupting other, growth-permissive motifs...
May 15, 2018: ELife
https://www.readbyqxmd.com/read/29760175/modulation-of-receptor-protein-tyrosine-phosphatase-sigma-increases-chondroitin-sulfate-proteoglycan-degradation-through-cathepsin-b-secretion-to-enhance-axon-outgrowth
#9
Amanda Phuong Tran, Sapna Sundar, Meigen Yu, Bradley T Lang, Jerry Silver
Severed axon tips reform growth cones following spinal cord injury that fail to regenerate, in part, because they become embedded within an inhibitory extracellular matrix. Chondroitin sulfate proteoglycans (CSPGs) are the major axon inhibitory matrix component that is increased within the lesion scar and in perineuronal nets around deafferented neurons. We have recently developed a novel peptide modulator (Intracellular Sigma Peptide or ISP) of the cognate receptor of CSPGs, protein tyrosine phosphatase sigma (RPTPσ), which has been shown to markedly improve sensorimotor function, micturition, and coordinated locomotor behavior in spinal cord contused rats...
May 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29758159/redox-responsive-micellar-nanoparticles-from-glycosaminoglycans-for-cd44-targeted-drug-delivery
#10
Ana M Carvalho, Raquel Teixeira, Ramon Novoa-Carballal, Ricardo A Pires, Rui L Reis, Iva Pashkuleva
Cancer progression is associated with overexpression of various receptors at the cell surface. Among these, CD44 is known to recognize and bind specifically hyaluronan (HA) and interact with less affinity to other glycosaminoglycans (GAGs), such as chondroitin sulfate (CS). In this study, we describe a simple method to obtain micellar nanoparticles with GAGs shell (HA or CS) as potential drug delivery systems that target cancer cells overexpressing CD44. Alkane thiol was conjugated at the reducing end of the respective GAG using highly efficient oxime chemistry...
May 14, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29756448/an-approach-to-synthesize-chondroitin-sulfate-e-cs-e-oligosaccharides-precursors
#11
Shuang Yang, Qi Liu, Guangyan Zhang, Xiaoxi Zhang, Zhehui Zhao, Pingsheng Lei
An approach was developed to synthesize chondroitin sulfate-E (CS-E) oligosaccharides by adopting a postglycosylation-transformation strategy: different from all the traditional approaches, the characteristic groups of CS-E were introduced following the assembly of the oligosaccharides. The adjusted strategy rendered an easy chain elongation strategy. All the elongation steps generated high yields with excellent glycosylation outcomes. An orthogonally protected disaccharide was used as the building block to provide flexibility for the group transformation and derivatization at the N-2 position of the GalNAc residue and the O-1,5 positions of the GlcA residue, thereby providing ready access for the further examination of the structure-activity relationship (SAR) of CS-E molecules...
May 14, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29753911/aggrecan-like-biomimetic-proteoglycans-bpgs-composed-of-natural-chondroitin-sulfate-bristles-grafted-onto-poly-acrylic-acid-core-for-molecular-engineering-of-the-extracellular-matrix
#12
K Prudnikova, S E Lightfoot Vidal, S Sarkar, T Yu, R W Yucha, N Ganesh, L S Penn, L Han, C L Schauer, E J Vresilovic, M S Marcolongo
Biomimetic proteoglycans (BPGs) were designed to mimic the three-dimensional (3D) bottlebrush architecture of natural extracellular matrix (ECM) proteoglycans, such as aggrecan. BPGs were synthesized by grafting native chondroitin sulfate bristles onto a synthetic poly(acrylic acid) core to form BPGs at a molecular weight of approximately ∼1.6 MDa. The aggrecan mimics were characterized chemically, physically, and structurally, confirming the 3D bottlebrush architecture as well as a level of water uptake, which is greater than that of the natural proteoglycan, aggrecan...
May 10, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29752110/evaluation-of-nano-hydrogel-composite-based-on-gelatin-ha-cs-suffused-with-asiatic-acid-zno-and-cuo-nanoparticles-for-second-degree-burns
#13
Thanusha A V, Amit Kumar Dinda, Veena Koul
In the present work, a hydrogel platform composed of biopolymer gelatin, and glycosaminoglycan's (Hyaluronic acid and Chondroitin sulfate) incorporated with Asiatic acid (a triterpenoid) and nanoparticles (Zinc oxide and Copper oxide) has been designed and developed to find out the efficacy of healing in second degree burn wounds in Wistar rats. The developed hydrogel composite has been characterized by physico-chemical methods such as; SEM, swelling, mechanical strength, degradation and drug release kinetics...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29747133/time-dependent-changes-in-gene-expression-induced-in-vitro-by-interleukin-1%C3%AE-in-equine-articular-cartilage
#14
Maria Löfgren, Emilia Svala, Anders Lindahl, Eva Skiöldebrand, Stina Ekman
Osteoarthritis is an inflammatory and degenerative joint disease commonly affecting horses. To identify genes of relevance for cartilage pathology in osteoarthritis we studied the time-course effects of interleukin (IL)-1β on equine articular cartilage. Articular cartilage explants from the distal third metacarpal bone were collected postmortem from three horses without evidence of joint disease. The explants were stimulated with IL-1β for 27 days and global gene expression was measured by microarray. Gene expression was compared to that of unstimulated explants at days 3, 9, 15, 21 and 27...
May 1, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29739851/lc-ms-ms-characterization-of-xyloside-primed-glycosaminoglycans-with-cytotoxic-properties-reveals-structural-diversity-and-novel-glycan-modifications
#15
Andrea Persson, Alejandro Gomez Toledo, Egor Vorontsov, Waqas Nasir, Daniel Willén, Fredrik Noborn, Ulf Ellervik, Katrin Mani, Jonas Nilsson, Göran Larson
Structural characterization of glycosaminoglycans remains a challenge but is essential for determining structure-function relationships between glycosaminoglycans and the biomolecules with which they interact and for gaining insight into the biosynthesis of glycosaminoglycans. We have recently reported that xyloside-primed chondroitin/dermatan sulfate derived from a human breast carcinoma cell line, HCC70, has cytotoxic effects and shown that it differs in disaccharide composition from non-toxic chondroitin/dermatan sulfate derived from a human breast fibroblast cell line, CCD-1095Sk...
May 8, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29737828/light-activated-ros-responsive-nanoplatform-co-delivering-apatinib-and-doxorubicin-for-enhanced-chemo-photodynamic-therapy-of-multidrug-resistant-tumors
#16
Xiao Wei, Lingqiao Liu, Xing Guo, Yi Wang, Jingya Zhao, Shaobing Zhou
Cancer chemotherapy faces the problem of the multidrug resistance (MDR) of tumor cells, which is a puzzling issue that leads to treatment failure. To address it, an innovative approach is proposed to construct a light-activated reactive oxygen species (ROS)-responsive nanoplatform based on a protoporphyrin (PpIX)-conjugated and dual chemotherapeutics-loaded polymer micelle. This system combines chemotherapy and photodynamic therapy (PDT) to defeat the MDR of tumors. Such an intelligent nanocarrier can prolong the blood circulation due to the negatively charged polysaccharide component of chondroitin sulfate (CS) and subsequently being selectively internalized by DOX-resistant human breast cancer MCF-7 cells (MCF-7/ADR)...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29737330/therapy-for-cartilage-defects-functional-ectopic-cartilage-constructed-by-cartilage-simulating-collagen-chondroitin-sulfate-and-hyaluronic-acid-cch-hybrid-hydrogel-with-allogeneic-chondrocytes
#17
Xianfang Jiang, Junting Liu, Qin Liu, Zhenhui Lu, Li Zheng, Jinmin Zhao, Xingdong Zhang
OBJECTIVE: To regenerate functional cartilage-mimicking ectopic cartilage as a source for the restoration of cartilage defects, we used a previously synthesized three-phase collagen, chondroitin sulfate and hyaluronic acid (CCH) hydrogel for the encapsulation of allogeneic chondrocytes with a diffusion chamber system that was buried subcutaneously in the host for 4 weeks and then implanted into a cartilage defect. METHODS: The CCH hydrogel was prepared and seeded with allogeneic chondrocytes from new-born rabbits, prior to being enveloped in a diffusion chamber that prevents cell ingrowth and vascular invasion of the host, as described previously...
May 8, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29736574/promising-biomolecules
#18
Isabel Oliveira, Ana L Carvalho, Hajer Radhouani, Cristiana Gonçalves, J Miguel Oliveira, Rui L Reis
The osteochondral defect (OD) comprises the articular cartilage and its subchondral bone. The treatment of these lesions remains as one of the most problematic clinical issues, since these defects include different tissues, requiring distinct healing approaches. Among the growing applications of regenerative medicine, clinical articular cartilage repair has been used for two decades, and it is an effective example of translational medicine; one of the most used cell-based repair strategies includes implantation of autologous cells in degradable scaffolds such as alginate, agarose, collagen, chitosan, chondroitin sulfate, cellulose, silk fibroin, hyaluronic acid, and gelatin, among others...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29733455/the-chemokine-fragment-cxcl9-74-103-diminishes-neutrophil-recruitment-and-joint-inflammation-in-antigen-induced-arthritis
#19
Daiane Boff, Helena Crijns, Rik Janssens, Vincent Vanheule, Gustavo B Menezes, Soraia Macari, Tarcilia A Silva, Flavio A Amaral, Paul Proost
This study investigates if treatment with a peptide corresponding to the 30 C-terminal amino acids of CXCL9, CXCL9(74-103), ameliorates joint inflammation in a murine model of antigen-induced arthritis (AIA). AIA was induced in male C57BL/6J mice. Intravenous injection of CXCL9(74-103), simultaneously performed with a tibiofemoral challenge with methylated BSA (mBSA) as antigen in mice immunized with mBSA, diminished the accumulation of leukocytes, in particular neutrophils, in the synovial cavity. The levels of the chemokines CXCL1, CXCL2, and CXCL6 and of the cytokine IL-6 were decreased in inflamed periarticular tissue of mice treated with the CXCL9-derived peptide compared to non-treated AIA mice...
May 7, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29727731/effects-of-long-term-rapamycin-treatment-on-glial-scar-formation-after-cryogenic-traumatic-brain-injury-in-mice
#20
Yan-Ying Fan, Fang Nan, Bao-Lu Guo, Yan Liao, Ming-Sheng Zhang, Jie Guo, Bao-Long Niu, Yue-Qin Liang, Cai-Hong Yang, Yi Zhang, Xuan-Ping Zhang, Xue-Fen Pang
Glial scar impedes axon regeneration and functional recovery following traumatic brain injury (TBI). Although it has been shown that rapamycin (a specific inhibitor of mammalian target of rapamycin) can reduce astrocyte reactivation in the early stage of TBI, its effect on glial scar formation has not been characterized in TBI and other acute brain injury models. To test this, ICR mice received daily administration of rapamycin (0.5 or 1.5 mg/kg, i.p.) beginning at 1 h after cryogenic TBI (cTBI). The results showed that at 3 d post-injury, 1...
May 1, 2018: Neuroscience Letters
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