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https://www.readbyqxmd.com/read/29227558/rna-sequencing-identifies-gene-regulatory-networks-controlling-extracellular-matrix-synthesis-in-intervertebral-disk-tissues
#1
Scott M Riester, Yang Lin, Wei Wang, Lin Cong, Abdel-Moneim Mohamed Ali, Sun H Peck, Lachlan J Smith, Bradford L Currier, Michelle Clark, Paul Huddleston, William Krauss, Michael J Yaszemski, Mark E Morrey, Matthew P Abdel, Mohamad Bydon, Wenchun Qu, A Noelle Larson, Andre J van Wijnen, Ahmad Nassr
Degenerative disk disease of the spine is a major cause of back pain and disability. Optimization of regenerative medical therapies for degenerative disk disease requires a deep mechanistic understanding of the factors controlling the structural integrity of spinal tissues. In this investigation, we sought to identify candidate regulatory genes controlling extracellular matrix synthesis in spinal tissues. To achieve this goal we performed high throughput next generation RNA sequencing on 39 annulus fibrosus and 21 nucleus pulposus human tissue samples...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29187309/a-finite-element-analysis-of-stress-distribution-and-disk-displacement-in-response-to-lumbar-rotation-manipulation-in-the-sitting-and-side-lying-positions
#2
Li Li, Tong Shen, Yi-Kai Li
OBJECTIVE: This study aimed to investigate stress distribution and disk displacement in healthy and degenerated intervertebral disks during simulated lumbar rotation manipulation (LRM) in the sitting and side-lying positions. METHODS: Three-dimensional (3D) finite element models of healthy, mildly degenerated and moderately degenerated L4/5 spinal units were reconstructed. Lumbar rotation manipulation in the sitting and side-lying positions were simulated, and alterations in stress distribution and disk displacement in the lumbar disks were observed...
October 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29106681/common-missense-variant-of-scn9a-gene-is-associated-with-pain-intensity-in-patients-with-chronic-pain-from-disc-herniation
#3
Mateusz Kurzawski, Marcin Rut, Violetta Dziedziejko, Krzysztof Safranow, Anna Machoy-Mokrzynska, Marek Drozdzik, Monika Bialecka
Objective: Lumbar intervertebral disk herniation (LDH) is considered one of the major risk factors for lower back pain, mainly caused by irritation of a spinal nerve or its root. One of the genes related to pain perception is SCN9A, which encodes the voltage gated sodium channel NaV1.7, a key molecule involved in peripheral pain processing. It had been presented before that a common polymorphism within SCN9A (rs6746030: G > A, R1150W) might influence nociception in the general population...
November 2, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29099681/beyond-the-laboratory-into-the-clinic-what-dogs-with-disk-disease-have-taught-us-about-photobiomodulation-for-spinal-cord-injury
#4
Narda G Robinson
BACKGROUND: For spinal-cord-injured (SCI) patients, integrative medicine approaches such as photomedicine and acupuncture can renew hope and offer previously unrecognized ways to help regain function and improve quality of life. OBJECTIVE: By understanding the mechanisms of action that these two modalities share, practitioners can better target specific attributes of spinal cord pathophysiology that are limiting recovery. Naturally occurring intervertebral disk disease (IVDD) in dogs affords unparalleled translational opportunities to develop treatment strategies involving photobiomodulation and acupuncture...
November 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29098359/a-murine-model-for-human-eco-syndrome-reveals-a-critical-role-of-intestinal-cell-kinase-in-skeletal-development
#5
Mengmeng Ding, Li Jin, Lin Xie, So Hyun Park, Yixin Tong, Di Wu, A Bobby Chhabra, Zheng Fu, Xudong Li
An autosomal-recessive inactivating mutation R272Q in the human intestinal cell kinase (ICK) gene caused profound multiplex developmental defects in human endocrine-cerebro-osteodysplasia (ECO) syndrome. ECO patients exhibited a wide variety of skeletal abnormalities, yet the underlying mechanisms by which ICK regulates skeletal development remained largely unknown. The goal of this study was to understand the structural and mechanistic basis underlying skeletal anomalies caused by ICK dysfunction. Ick R272Q knock-in transgenic mouse model not only recapitulated major ECO skeletal defects such as short limbs and polydactyly but also revealed a deformed spine with defective intervertebral disk...
November 2, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29097954/redundant-nerve-root-in-a-patient-with-chronic-lumbar-degenerative-canal-stenosis
#6
Federico E Villafañe, Allison Harvey, Norman Kettner
Objective: The purpose of this case report is to describe the diagnostic imaging features of redundant nerve roots caused by chronic lumbar degenerative canal stenosis (CLDCS). Clinical Features: A 56-year-old male presented with severe low back pain. He experienced pain during minimal active lumbar range of motion. The patient demonstrated weakness of the right iliopsoas and hypoesthesia of the L-2 dermatome. A working diagnosis of CLDCS was established. The patient's worsening severe low back pain warranted magnetic resonance imaging of the lumbar spine, which was performed for further evaluation...
September 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29074336/the-role-of-fenestration-in-management-of-type-i-thoracolumbar-disk-degeneration
#7
REVIEW
Nick D Jeffery, Paul M Freeman
Fenestration offers the advantages of prophylaxis without the need for specialized instrumentation and imaging. Currently there is a lack of equipoise regarding the efficacy of fenestration relative to decompression for treatment of acute canine intervertebral disk herniation; most veterinary spinal surgeons do not consider the 2 procedures equivalently efficacious. Therapeutic fenestration should perhaps be given greater consideration, especially if advanced imaging shows only mild to moderate spinal cord compression or there are restrictions on the duration of surgery, when it might be better to spend the time on fenestration rather than decompression...
October 23, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29074335/choices-and-decisions-in-decompressive-surgery-for-thoracolumbar-intervertebral-disk-herniation
#8
REVIEW
Nick D Jeffery, Tom R Harcourt-Brown, Andrew K Barker, Jonathan M Levine
Once decompressive surgery has been elected, the approach that maximizes the likelihood of gaining access to the herniated material for complete removal should be chosen. In most cases, a procedure that optimizes access to the ventrolateral aspect of the spinal cord will be advantageous but it is important to tailor the details of the surgical procedure to suit individual patients. Decompressive surgery for chronic (type II) herniations will frequently demand a ventral approach with partial corpectomy.
October 23, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29065658/atlas-free-cervical-spinal-cord-segmentation-on-midsagittal-t2-weighted-magnetic-resonance-images
#9
Chun-Chih Liao, Hsien-Wei Ting, Furen Xiao
An automatic atlas-free method for segmenting the cervical spinal cord on midsagittal T2-weighted magnetic resonance images (MRI) is presented. Pertinent anatomical knowledge is transformed into constraints employed at different stages of the algorithm. After picking up the midsagittal image, the spinal cord is detected using expectation maximization and dynamic programming (DP). Using DP, the anterior and posterior edges of the spinal canal and the vertebral column are detected. The vertebral bodies and the intervertebral disks are then segmented using region growing...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29057987/magnetic-resonance-imaging-features-of-dogs-with-incomplete-recovery-after-acute-severe-spinal-cord-injury
#10
Melissa J Lewis, Eli B Cohen, Natasha J Olby
STUDY DESIGN: Retrospective case series. OBJECTIVES: Describe the magnetic resonance imaging (MRI) features of dogs chronically impaired after severe spinal cord injury (SCI) and investigate associations between imaging variables and residual motor function. SETTING: United States of America. METHODS: Thoracolumbar MRI from dogs with incomplete recovery months to years after clinically complete (paralysis with loss of pain perception) thoracolumbar SCI were reviewed...
October 23, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29049074/physiology-and-role-of-intraocular-pressure-in-contemporary-anesthesia
#11
Dermot J Kelly, Sinéad M Farrell
More than 26 million Americans suffer with cataracts, and with 3.6 million cataract extractions performed annually in the United States, it is the most common surgical procedure. The integrity of the delicate structures of the eye that mediate vision is dependent on the intraocular pressure (IOP). Yet, IOP acts to compress the vessels within the globe-akin to a Starling resistor-and is a key component that determines the ocular perfusion pressure, defined as the difference between arterial pressure and IOP...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29019804/quantification-of-propionic-acid-in-the-bovine-spinal-disk-after-infection-of-the-tissue-with-p-acnes-bacteria
#12
Sergey Magnitsky, Stefan Dudli, Xinyan Tang, Jaskanwaljeet Kaur, Joycelyn Diaz, Steve Miller, Jeffrey C Lotz
STUDY DESIGN: Research OBJECTIVE.: The goal of this study was to investigate whether P. acnes infection of the intervertebral disc can be detected noninvasively by NMR spectroscopy. SUMMARY OF BACKGROUND DATA: Microbiological studies of surgical samples suggest that a significant subpopulation of back pain patients may have occult disc infection with P. acnes bacteria. This hypothesis is further supported by a double-blind clinical trial showing that back pain patients with Modic type 1 changes may respond to antibiotic treatment...
October 10, 2017: Spine
https://www.readbyqxmd.com/read/29019639/spine-conditions-cervical-spine-conditions
#13
Marc A Childress
There are a variety of causes of neck pain, including trauma and degenerative changes. The history of onset helps to direct evaluation, including the need for imaging or ancillary testing. Patterns of pain, weakness, and other specific physical examination findings also aid in diagnosis. Management of most soft tissue injuries involves early mobilization, whereas fractures are managed based on patterns of instability. Acute spinal cord injury requires emergent care, to include possible decompressive surgery...
October 2017: FP Essentials
https://www.readbyqxmd.com/read/28960477/real-time-ultrasound-assessment-of-astronaut-spinal-anatomy-and-disorders-on-the-international-space-station
#14
Kathleen M Garcia, Michael F Harrison, Ashot E Sargsyan, Douglas Ebert, Scott A Dulchavsky
OBJECTIVES: Back pain is one of the most common conditions of astronauts during spaceflight and is hypothesized to be attributed to pathologic anatomic changes. Ultrasound (US) represents the only available imaging modality on the International Space Station, but a formal US protocol for imaging the structures of the spinal column does not exist. This investigation developed a method of acquiring diagnostic-quality images of the anterior lumbar and cervical regions of the spine during long-duration spaceflight...
September 29, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28955299/the-pathogenesis-of-ventral-idiopathic-herniation-of-the-spinal-cord-a-hypothesis-based-on-the-review-of-the-literature
#15
Ronald H M A Bartels, Han Brunner, Allard Hosman, Nens van Alfen, J André Grotenhuis
Idiopathic ventral herniation of the spinal cord (SC) is not often encountered in daily practice. Its clinical prevalence, however, will increase through increasing awareness and more frequent use of MRI. A clear explanation of its pathophysiology has never been formulated. It was hypothesized that the findings during surgery might indicate the real causative mechanism. An extensive literature search was performed, using Embase, PubMed, and Google Scholar. Titles and abstracts were screened by two investigators, using strict inclusion and exclusion criteria...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28948122/a-case-of-persistent-low-back-pain-in-a-young-female-caused-by-a-trauma-induced-schmorl-s-node-in-the-lumbar-spine-five-vertebra
#16
Kurt M Mohty, Divneet Mandair, Brent Munroe, Deborah Baldemor
Physicians are often faced with managing difficult conditions such as chronic lower back pain. Intervertebral disk herniation typically occurs horizontally, leading to impingement of the spinal cord which can potentially cause radicular symptoms or other spinal cord pathologies; however, disk herniations can also occur vertically and extend through the endplate of an adjacent cranial or caudal vertebra: a phenomenon known as a Schmorl's node. Although Schmorl's nodes can be seen in many asymptomatic individuals, they can be a cause of degenerative disk disease and low back pain...
July 21, 2017: Curēus
https://www.readbyqxmd.com/read/28914655/percutaneous-nucleoplasty-for-the-treatment-of-a-contained-cervical-disk-herniation
#17
Judith D de Rooij, Pravesh S Gadjradj, John S Soria van Hoeve, Frank J Huygen, Hans A Aukes, Biswadjiet S Harhangi
Cervical radiculopathy is characterized by compression of the roots of the nerve. When conservative treatment fails and symptoms persist or increase in severity, surgical treatment is considered. Anterior cervical discectomy with or without fusion is regarded as the standard treatment for cervical disk herniation. Recently, there is an evolving trend in spinal surgery towards less invasive techniques. Nucleoplasty is a minimally invasive technique in which radiofrequency technology is used for percutaneous decompression...
November 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28846710/apparent-diffusion-coefficient-maps-in-the-assessment-of-surgical-patients-with-lumbar-spine-degeneration
#18
Evgenii Belykh, Andrey A Kalinin, Arpan A Patel, Eric J Miller, Michael A Bohl, Ivan A Stepanov, Liudmila A Bardonova, Talgat Kerimbaev, Anton O Asantsev, Morgan B Giers, Mark C Preul, Vadim A Byvaltsev
PURPOSE: To assess the utility of apparent diffusion coefficient (ADC) maps for the assessment of patients with advanced degenerative lumbar spine disease and describe characteristic features of ADC maps in various degenerative lumbar spinal conditions. METHODS: T1-weighted, T2-weighted and diffusion weighted (DWI) MR images of 100 consecutive patients admitted to the spinal surgery service were assessed. ADC maps were generated from DWI images using Osyrix software...
2017: PloS One
https://www.readbyqxmd.com/read/28803171/open-versus-minimally-invasive-surgery-for-extraforaminal-lumbar-disk-herniation-a-systematic-review-and-meta-analysis
#19
REVIEW
Oluwaseun O Akinduro, Panagiotis Kerezoudis, Mohammed Ali Alvi, Jangwon Yoon, Jamachi Eluchie, Hasan M Murad, Zhen Wang, Selby G Chen, Mohamad Bydon
INTRODUCTION: Extraforaminal disk herniation (EDH) accounts for 3-11% of all disk herniations. Despite the heterogeneity of spinal procedures, there is a paucity of literature comparing the outcomes from different surgical approaches. METHODS: We performed a systematic review and meta-analysis of available literature on EDHs. We compared patients undergoing open surgery (OS) with those undergoing minimally invasive surgery (MIS) approaches, including tubular microscopic, percutaneous endoscopic, and micro-endoscopic...
August 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28796075/muscle-gap-approach-under-a-minimally-invasive-channel-technique-for-treating-long-segmental-lumbar-spinal-stenosis-a-retrospective-study
#20
Yang Bin, Wang De Cheng, Wang Zong Wei, Li Hui
This study aimed to compare the efficacy of muscle gap approach under a minimally invasive channel surgical technique with the traditional median approach.In the Orthopedics Department of Traditional Chinese and Western Medicine Hospital, Tongzhou District, Beijing, 68 cases of lumbar spinal canal stenosis underwent surgery using the muscle gap approach under a minimally invasive channel technique and a median approach between September 2013 and February 2016. Both approaches adopted lumbar spinal canal decompression, intervertebral disk removal, cage implantation, and pedicle screw fixation...
August 2017: Medicine (Baltimore)
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