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https://www.readbyqxmd.com/read/28747152/associations-between-male-infertility-and-ancestry-in-south-americans-a-case-control-study
#1
Maria Fernanda Skowronek, Tatiana Velazquez, Patricia Mut, Gonzalo Figueiro, Monica Sans, Bernardo Bertoni, Rossana Sapiro
No abstract text is available yet for this article.
July 26, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28746835/genetic-ataxia-telangiectasia-porcine-model-phenocopies-the-multisystemic-features-of-the-human-disease
#2
Rosanna Beraldi, David K Meyerholz, Alexei Savinov, Attila D Kovács, Jill M Weimer, Jordan A Dykstra, Ryan D Geraets, David A Pearce
Ataxia telangiectasia (AT) is a progressive multisystem autosomal recessive disorder caused by mutations in the AT-mutated (ATM) gene. Early onset AT in children is characterized by cerebellar degeneration, leading to motor impairment. Lung disease and cancer are the two most common causes of death in AT patients. Accelerated thymic involution may contribute to the cancer, and recurrent and/or chronic respiratory infections may be a contributing factor to lung disease in AT. AT patients have fertility issues, are highly sensitive to ionizing radiation and they present oculocutaneous telangiectasia...
July 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28746727/idiopathic-male-infertility-related-to-periodontal-and-caries-status
#3
Nándor Práger, Norbert Pásztor, Ákos Várnagy, Zoltan Kozinszky, Zoltán Baráth, István Gorzó, Márta Radnai
OBJECTIVES: The present study was undertaken to evaluate the possible correlation between the periodontal and dental status and sperm pathology in idiopathic male infertility. METHODS: The periodontal and caries status and semen quality of 199 men presented with unexplained male infertility were examined. Periodontal and dental factors were analyzed by sperm pathology categories. RESULTS: 106 men had normal sperm parameters, whereas 93 men had some type of spermpathology; 27...
July 26, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28745849/pelvic-inflammatory-disease-diagnosis-and-treatment-in-the-emergency-department-digest
#4
Charles Walter Bugg, Taku Taira, Milana Zaurova
Pelvic inflammatory disease is a common disease that is associated with significant complications including infertility, chronic pelvic pain, ruptured tubo-ovarian abscess, and ectopic pregnancy. The diagnosis may be delayed when the presentation has nonspecific signs and symptoms. Even when it is properly identified, pelvic inflammatory disease is often treated suboptimally. This review provides evidence-based recommendations for the diagnosis, treatment, disposition, and follow-up of patients with pelvic inflammatory disease...
December 22, 2016: Emergency Medicine Practice
https://www.readbyqxmd.com/read/28745706/-the-combination-of-endoscopic-techniques-in-the-diagnosis-and-treatment-of-various-forms-of-infertility-in-women
#5
N N Akhundova
AIM: To improve the methods of simultaneous laparoscopy and hysteroscopy for the diagnosis and treatment of various forms of secondary infertility. MATERIAL AND METHODS: 420 women with various forms of infertility were examined and treated at the Caspian Hospital (Institute of Obstetrics and Gynecology). Patients were divided into three groups: tubal-peritoneal infertility - 212 women, different forms of endometriosis - 113 patients, polycystic ovarian disease - 95 women...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28744794/propensity-score-matched-study-and-meta-analysis-of-cumulative-outcomes-of-day-2-3-versus-day-5-6-embryo-transfers
#6
Ye Yin, Ge Chen, Kezhen Li, Qiuyue Liao, Sijia Zhang, Nieying Ma, Jing Chen, Yan Zhang, Jihui Ai
The superiority of the cumulative outcomes of day 5/6 embryo transfer to those of day 2/3 embryo transfer in infertile couples has been debated. This retrospective study included data collected from 1051 patients from July 2011 to June 2014. Multiple maternal baseline covariates were subjected to propensity score matching analysis, and each day 5/6 group woman was matched to one day 2/3 group woman. A systematic meta-analysis was conducted to validate the results. After matching was completed, 217 patients on the day 2/3 group were matched with those on the day 5/6 group, and no significant differences in the baseline characteristics were observed between the two groups...
July 25, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28744742/the-primary-result-of-prospective-randomized-multicenter-trial-of-new-spray-type-bio-absorbable-adhesion-barrier-system-tcd-11091-against-postoperative-adhesion-formation
#7
Takeshi Suto, Masahiko Watanabe, Takeshi Endo, Koji Komori, Masayuki Ohue, Yukihide Kanemitsu, Masaaki Itou, Yasumasa Takii, Toshimasa Yatsuoka, Manabu Shiozawa, Tetsushi Kinugasa, Hideki Ueno, Tadatoshi Takayama, Tadahiko Masaki, Hiroyuki Masuko, Hisanaga Horie, Masafumi Inomata
BACKGROUND: Postoperative adhesions are the major cause of postoperative complications including intestinal obstruction, infertility, and chronic pelvic pain. In order to reduce postoperative adhesions, Terumo Corporation (Tokyo, Japan) has developed an adhesion barrier system (TCD-11091) which is easy to use at the treatment site in various surgical procedures including laparoscopic surgeries. We conducted a prospective randomized single-blind study in patients who underwent laparotomy with ileostomy...
July 25, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28744640/features-of-lipoperoxidation-antioxidant-defense-and-thiol-disulfide-system-in-the-pathogenesis-of-infertility-in-males-carriers-of-nonfunctional-variants-of-gstt1-and-gstm1-gene-polymorphisms
#8
L I Kolesnikova, N A Kurashova, T A Bairova, M I Dolgikh, O A Ershova, L V Natyaganova, B G Dashiev, I N Gutnik, N V Koroleva
Comparative analysis of the parameters of LPO, antioxidant defense (AOD), and the thiol/disulfide system was performed in fertile and infertile males of reproductive age carrying different genotypes of the glutathione system genes. Blood plasma, blood hemolysate, and ejaculate served as specimens for biochemical studies. A decrease in glutathione S-transferase activity was found in blood and ejaculate specimens from fertile and infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes. In infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes determining reduced glutathione S-transferase activity, a decrease in the concentration of low-molecular-weight cell antioxidant (reduced glutathione) and an increase in the concentration of secondary LPO products (TBA-reactive substances) were revealed...
July 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28743560/fertility-and-anogenital-distance-in-women
#9
Tamar Wainstock, Ilana Shoham-Vardi, Eyal Sheiner, Asnat Walfisch
BACKGROUND: Human and animal studies have found an association between prenatal androgen exposure and the anogenital distance (AGD). The aims of this study were to study the association between female AGD, reproductive health and background characteristics. METHODS: This was a cross sectional study, in which AGD were measured in 300 pregnant women who were recruited early during the first stage of labor. Demographic and health characteristics were collected and studied in association with AGD measurements...
July 22, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28743519/the-molecular-complexity-of-primary-ovarian-insufficiency-aetiology-and-the-use-of-massively-parallel-sequencing
#10
REVIEW
Paul Laissue
Primary ovarian insufficiency (POI) is a frequently occurring pathology, leading to infertility. Genetic anomalies have been described in POI and mutations in numerous genes have been definitively related to the pathogenesis of the disease. Some studies based on next generation sequencing (NGS) have been successfully undertaken as they have led to identify new mutations associated with POI aetiology. The purpose of this review is to present the most relevant molecules involved in diverse complex pathways, which may contribute towards POI...
July 22, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28743298/r-spondin2-a-novel-target-of-nobox-identification-of-variants-in-a-cohort-of-women-with-primary-ovarian-insufficiency
#11
Justine Bouilly, Isabelle Beau, Sara Barraud, Valérie Bernard, Brigitte Delemer, Jacques Young, Nadine Binart
BACKGROUND: R-spondin2 (Rspo2) is a secreted agonist of the canonical Wnt/β-catenin signaling pathway. Rspo2 plays a key role in development of limbs, lungs and hair follicles, and more recently during ovarian follicle development. Rspo2 heterozygous deficient female mice become infertile around 4 months of age mimicking primary ovarian insufficiency (POI). The study aimed to investigate the regulation of RSPO2 and its potential involvement in pathophysiology of POI. METHODS: We cloned the RSPO2 promoter and performed transcriptional assays to determine if RSPO2 can be regulated by NOBOX, an ovarian transcription factor...
July 25, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28742586/summary-of-future-developments
#12
Jessica R Zolton, Alan Decherney
Endometriosis is a chronic disease with the potential to cause devastating clinical manifestations such as infertility and chronic pelvic disease. Current treatment is limited to surgical intervention and pharmacologic therapy targeting estrogen and progesterone to suppress ectopic endometrial tissue proliferation. Undesired side effects and contraindications to the use of hormonal medications may reduce treatment options. As the pathogenesis of endometriosis continues to be investigated, new therapies will emerge...
September 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742581/fertility-and-endometriosis
#13
M Blake Evans, Alan H Decherney
Approximately 30% to 50% of women that have the diagnosis of endometriosis also struggle with infertility. Twenty five percent to 50% of women diagnosed with infertility also have endometriosis, but the endometriosis may not be severe enough to be the primary etiology of infertility. White women have been reported to be more likely than African American women to have endometriosis. In addition, risk factors for endometriosis include below average body mass index, smoking, and alcohol use. Below is a discussion regarding the various ways in which endometriosis decreases fecundity and also discusses potential outcomes of fertility treatments regarding endometriosis...
September 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28741010/perception-of-a-single-session-pre-in-vitro-fertilisation-counselling-service-and-attitudes-towards-support-group-a-survey-of-patients-in-singapore
#14
Gaik Suan Lim, Reshmi Karayan Kayanoth, Birit Fp Broekman, Cornelia Yi Chee
INTRODUCTION: This study aimed to investigate patients' evaluation of a compulsory pre-in vitro fertilisation (IVF) counselling session in Singapore and determine their attitudes towards attending a support group during IVF treatment. METHODS: 464 patients due to undergo their first IVF treatment were recruited at the Clinic for Human Reproduction, National University Hospital, Singapore. All patients attended a counselling session conducted by a clinical psychologist trained in infertility counselling prior to IVF treatment...
July 25, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28739800/cell-free-production-of-a-functional-oligomeric-form-of-a-chlamydia-major-outer-membrane-protein-momp-for-vaccine-development
#15
Wei He, Martina Felderman, Angela C Evans, Jia Geng, David Homan, Feliza Bourguet, Nicholas O Fischer, Yuanpei Li, Kit S Lam, Aleksandr Noy, Li Xing, R Holland Cheng, Amy Rasley, Craig D Blanchette, Kurt Kamrud, Nathanial Wang, Heather Gouvis, Todd C Peterson, Bolyn Hubby, Matthew A Coleman
Chlamydia is a prevalent sexually transmitted disease that infects more than 100 million people worldwide. Although most individuals infected with Chlamydia trachomatis are initially asymptomatic, symptoms can arise if left undiagnosed. Long-term infection can result in debilitating conditions such as pelvic inflammatory disease, infertility, and blindness. Chlamydia infection, therefore, constitutes a significant public health threat, underscoring the need for a Chlamydia-specific vaccine. Chlamydia strains express a major outer-membrane protein (MOMP) that has been shown to be an effective vaccine antigen...
July 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28739435/ureaplasma-spp-in-male-infertility-and-its-relationship-with-semen-quality-and-seminal-plasma-components
#16
Yun Heng Zhou, Hong Xia Ma, Xiao Xing Shi, Yang Liu
OBJECTIVE: We investigated the prevalence of Ureaplasma spp. in semen samples of infertile men in Shanghai, China and evaluated the correlation between the sperm parameters (seminal volume, sperm concentration, progressive motility and non-progressive) and the secretary function in these infectious populations. METHODS: Semens were collected from 540 infertile men and 260 fertile control group in shanghai, China and subjected to standard bacterial and Ureaplasma spp...
June 22, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28739414/conservative-surgery-for-adenomyosis-and-results-a-systematic-review
#17
REVIEW
Grace Younes, Togas Tulandi
The traditional treatment for women with symptomatic adenomyosis is hysterectomy. However, reproductive aged women should be managed with less invasive treatments including medical treatment. For patients who are refractory or unsuitable to long term medical treatment, or those with focal adenomyoma, conservative surgeries could be offered. The objective of our study was to review available conservative surgeries for the treatment of adenomyosis, their complications, and the rates of success and recurrence...
July 21, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28738833/anxiety-and-depression-among-infertile-women-a-cross-sectional-survey-from-hungary
#18
Enikő Lakatos, Judit F Szigeti, Péter P Ujma, Réka Sexty, Piroska Balog
BACKGROUND: Infertility is often associated with a chronic state of stress which may manifest itself in anxiety-related and depressive symptoms. The aim of our study is to assess the psychological state of women with and without fertility problems, and to investigate the background factors of anxiety-related and depressive symptoms in women struggling with infertility. METHODS: Our study was conducted with the participation of 225 (134 primary infertile and 91 fertile) women, recruited in a clinical setting and online...
July 24, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28738736/bacterial-vaginosis-and-the-risk-of-early-miscarriage-in-women-undergoing-intracytoplasmic-sperm-injection-cycles-a-prospective-cohort-study
#19
Ashraf Moini, Ladan Mohammadi Yeganeh, Marzieh Shiva, Malihe Ahmadieh, Reza Salman Yazdi, Fatemeh Hasani, Narges Bagheri Lankarani, Azam Sanati
This study aimed to assess the possible association of bacterial vaginosis (BV) and early miscarriage in 408 women undergoing intracytoplasmic sperm injection (ICSI) for reasons of male infertility. A vaginal sample was obtained before oocyte retrieval and evaluated for BV-associated bacteria using the Nugent scoring system. The primary outcome was early miscarriage and the secondary outcomes included implantation, pregnancy, late miscarriage, preterm delivery and live birth rates. Chi-square, ANOVA, relative risk and odds ratio were used for data analysis where appropriate...
July 24, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28738699/caspase-3-gene-expression-in-human-luteinized-granulosa-cells-is-inversely-correlated-with-the-number-of-oocytes-retrieved-after-controlled-ovarian-stimulation
#20
Verônica N Lobach, Maíra Casalechi, Cynthia Dela Cruz, Maria T Pereira, Helen L Del Puerto, Fernando M Reis
Granulosa cells control oocyte maturation through paracrine signalling and changes to the microenvironment around the oocyte. Apoptosis occurs as a physiological mechanism of granulosa cell renewal, but how it relates with the ovarian response to induced ovulation is still unclear. Therefore, this study evaluated apoptosis-related gene expression levels in granulosa cells of patients undergoing controlled ovarian stimulation. We enrolled prospectively 59 consecutive IVF patients referred to a tertiary academic hospital for couple infertility treatment...
July 25, 2017: Human Fertility: Journal of the British Fertility Society
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