keyword
https://read.qxmd.com/read/38533453/inter-individual-variations-in-circadian-misalignment-induced-nafld-pathophysiology-in-mice
#21
JOURNAL ARTICLE
Nobuya Koike, Yasuhiro Umemura, Hitoshi Inokawa, Isao Tokuda, Yoshiki Tsuchiya, Yuh Sasawaki, Atsushi Umemura, Naoko Masuzawa, Kazuya Yabumoto, Takashi Seya, Akira Sugimoto, Seung-Hee Yoo, Zheng Chen, Kazuhiro Yagita
Pathological consequences of circadian misalignment, such as shift work, show considerable individual differences, but the lack of mechanistic understanding hinders precision prevention to prevent and mitigate disease symptoms. Here, we employed an integrative approach involving physiological, transcriptional, and histological phenotypes to examine inter-individual differences in pre-symptomatic pathological progression, preceding irreversible disease onset, in wild-type mice exposed to chronic jet-lag (CJL)...
February 16, 2024: IScience
https://read.qxmd.com/read/38533441/is-society-caught-up-in-a-death-spiral-modeling-societal-demise-and-its-reversal
#22
REVIEW
Michaéla C Schippers, John P A Ioannidis, Matthias W J Luijks
Just like an army of ants caught in an ant mill, individuals, groups and even whole societies are sometimes caught up in a Death Spiral, a vicious cycle of self-reinforcing dysfunctional behavior characterized by continuous flawed decision making, myopic single-minded focus on one (set of) solution(s), denial, distrust, micromanagement, dogmatic thinking and learned helplessness. We propose the term Death Spiral Effect to describe this difficult-to-break downward spiral of societal decline. Specifically, in the current theory-building review we aim to: (a) more clearly define and describe the Death Spiral Effect; (b) model the downward spiral of societal decline as well as an upward spiral; (c) describe how and why individuals, groups and even society at large might be caught up in a Death Spiral; and (d) offer a positive way forward in terms of evidence-based solutions to escape the Death Spiral Effect...
2024: Frontiers in sociology
https://read.qxmd.com/read/38533076/energy-demand-forecasting-using-convolutional-neural-network-and-modified-war-strategy-optimization-algorithm
#23
JOURNAL ARTICLE
Huanhuan Hu, Shufen Gong, Bahman Taheri
Predicting the electricity demand is a key responsibility for the energy industry and governments in order to provide an effective and dependable energy supply. Traditional projection techniques frequently rely on mathematical models, which are limited in their ability to recognize complex patterns and correlations in data. Machine learning has emerged as a viable tool for estimating electricity in the last decade. In this study, the Modified War Strategy Optimization-Based Convolutional Neural Network (MWSO-CNN) has been provided for electricity demand prediction...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533055/advances-in-machine-learning-and-iot-for-water-quality-monitoring-a-comprehensive-review
#24
REVIEW
Ismail Essamlali, Hasna Nhaila, Mohamed El Khaili
Water holds great significance as a vital resource in our everyday lives, highlighting the important to continuously monitor its quality to ensure its usability. The advent of the. The Internet of Things (IoT) has brought about a revolutionary shift by enabling real-time data collection from diverse sources, thereby facilitating efficient monitoring of water quality (WQ). By employing Machine learning (ML) techniques, this gathered data can be analyzed to make accurate predictions regarding water quality. These predictive insights play a crucial role in decision-making processes aimed at safeguarding water quality, such as identifying areas in need of immediate attention and implementing preventive measures to avert contamination...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533048/image-quality-of-abdominal-photon-counting-ct-with-reduced-contrast-media-dose-evaluation-of-reduced-contrast-media-protocols-during-the-covid19-pandemic-supply-shortage
#25
JOURNAL ARTICLE
Yannik C Layer, Alexander Isaak, Narine Mesropyan, Patrick A Kupczyk, Julian A Luetkens, Tatjana Dell, Ulrike I Attenberger, Daniel Kuetting
RATIONALE AND OBJECTIVES: Aim of this study was to assess the impact of contrast media dose (CMD) reduction on diagnostic quality of photon-counting detector CT (PCD-CT) and energy-integrating detector CT (EID-CT). METHODS: CT scans of the abdominal region with differing CMD acquired in portal venous phase on a PCD-CT were included and compared to EID-CT scans. Diagnostic quality and contrast intensity were rated. Additionally, readers had to assign the scans to reduced or regular CMD...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533041/a-study-on-work-family-life-imbalance-among-women-administrators-in-uae-higher-education-institutions
#26
JOURNAL ARTICLE
Vazeerjan Begum, Tahseen Anwer Arshi, Abdelfatah Said Arman, Atif Saleem Butt, Surjith Latheef
The study explored the factors causing work-family imbalance among women administrators in higher education institutions in the UAE and how it affects their personal and organizational well-being. The research found that the existing literature doesn't give enough attention to the mismatch between women administrators' work and family goals. Furthermore, it provides little insight into the integration of work-family support systems. The study applied the Spillover theory to explain that women administrators face significant work-family imbalances that adversely impact their personal well-being and organizational effectiveness...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533040/comprehensive-single-cell-analysis-reveals-heterogeneity-of-fibroblast-subpopulations-in-ovarian-cancer-tissue-microenvironment
#27
JOURNAL ARTICLE
Bo Ding, Zheng Ye, Han Yin, Xin-Yi Hong, Song-Wei Feng, Jing-Yun Xu, Yang Shen
BACKGROUND: Ovarian cancer, as a highly malignant tumor, features the critical involvement of tumor-associated fibroblasts in the ovarian cancer tissue microenvironment. However, due to the apparent heterogeneity within fibroblast subpopulations, the specific functions of these subpopulations in the ovarian cancer tissue microenvironment remain insufficiently elucidated. METHODS: In this study, we integrated single-cell sequencing data from 32 ovarian cancer samples derived from four distinct cohorts and 3226 bulk RNA-seq data from GEO and TCGA-OV cohorts...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533023/a-light-powered-self-rotating-liquid-crystal-elastomer-drill
#28
JOURNAL ARTICLE
Yong Yu, Haoyu Hu, Haiyang Wu, Yuntong Dai, Kai Li
Self-oscillating systems can directly convert ambient energy to mechanical work, and new type self-oscillating systems are worth designing for applications in energy harvesters, engines, and actuators. Taking inspiration from the hand drill, we have developed a novel self-rotating drill system, which is consist of a turnplate and a liquid crystal elastomer (LCE) fiber under steady illumination. To investigate the self-rotating behaviors of the LCE drill, we have proposed a nonlinear theoretical model of the LCE drill under steady illumination based on the well-established dynamic LCE model...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533008/crowdsourced-cycling-data-applications-to-estimate-noise-pollution-exposure-during-urban-cycling
#29
JOURNAL ARTICLE
Rebecca Wogan, John Kennedy
This research demonstrates a methodology to integrate freely available datasets to understand the relationship between road traffic noise and cycling experiences in a medium sized city. An illustrative example of the methodology was drawn from data for Dublin, Ireland. We aggregate local environmental data with 81,403 Strava cycle trips, contextualised by feedback from 335 cyclists to estimate exposure levels and infer impacts on experiences and behaviours. Results demonstrate that cyclists recognise that they are subjected to increased noise levels and experience negative psychophysical consequences as a result, but they tend to downplay the impact of noise as merely a minor annoyance...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533007/epigenetic-modification-a-novel-insight-into-diabetic-wound-healing
#30
REVIEW
Cong-Cong Ju, Xiao-Xiao Liu, Li-Hua Liu, Nan Guo, Le-Wei Guan, Jun-Xian Wu, De-Wu Liu
Wound healing is an intricate and fine regulatory process. In diabetic patients, advanced glycation end products (AGEs), excessive reactive oxygen species (ROS), biofilm formation, persistent inflammation, and angiogenesis regression contribute to delayed wound healing. Epigenetics, the fast-moving science in the 21st century, has been up to date and associated with diabetic wound repair. In this review, we go over the functions of epigenetics in diabetic wound repair in retrospect, covering transcriptional and posttranscriptional regulation...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533005/prognostic-correlation-between-specialized-capillary-endothelial-cells-and-lung-adenocarcinoma
#31
JOURNAL ARTICLE
Rongchang Zhao, Yan Ding, Rongbo Han, Rongjie Ding, Jun Liu, Chunrong Zhu, Dan Ding, Minhui Bao
BACKGROUND: In-depth analysis of the functional changes occurring in endothelial cells (ECs) involved in capillary formation can help to elucidate the mechanism of tumour vascular growth. METHODS: Appropriate datasets were retrieved from the GEO database to obtain single-cell data on LUAD samples and adjacent normal tissue samples. ECs were selected by an automatic annotation program in R and further subdivided based on reported EC marker genes. Functional changes in different types of capillary ECs were then visualized, and the concrete expression was classified by genetic data in the TCGA...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532999/detection-and-analysis-of-deteriorated-areas-in-solar-pv-modules-using-unsupervised-sensing-algorithms-and-3d-augmented-reality
#32
JOURNAL ARTICLE
Adel Oulefki, Yassine Himeur, Thaweesak Trongtirakul, Kahina Amara, Sos Agaian, Samir Benbelkacem, Mohamed Amine Guerroudji, Mohamed Zemmouri, Sahla Ferhat, Nadia Zenati, Shadi Atalla, Wathiq Mansoor
Solar Photovoltaic (PV) systems are increasingly vital for enhancing energy security worldwide. However, their efficiency and power output can be significantly reduced by hotspots and snail trails, predominantly caused by cracks in PV modules. This article introduces a novel methodology for the automatic segmentation and analysis of such anomalies, utilizing unsupervised sensing algorithms coupled with 3D Augmented Reality (AR) for enhanced visualization. The methodology outperforms existing segmentation techniques, including Weka and the Meta Segment Anything Model (SAM), as demonstrated through computer simulations...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532996/prognostic-insights-and-immune-microenvironment-delineation-in-acute-myeloid-leukemia-by-ferroptosis-derived-signature
#33
JOURNAL ARTICLE
Lijun Jing, Biyu Zhang, Jinghui Sun, Jueping Feng, Denggang Fu
Acute myeloid leukemia (AML) represents as a prevalent and formidable hematological malignancy, characterized by notably low 5-year survival rates. Ferroptosis has been found to be correlated with cancer initiation, therapeutic response, and clinical outcome. Nevertheless, the involvement of Ferroptosis-related genes (FRGs) in AML remains ambiguous. Five independent AML cohorts totaling 1,470 (GSE37642, GSE12417, GSE10358, Beat-AML, and TCGA-AML) patients with clinical information were used to systematically investigated the influence of these FRGs expression on outcome and tumor microenvironment...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532994/notopterol-mitigates-il-1%C3%AE-triggered-pyroptosis-by-blocking-nlrp3-inflammasome-via-the-jak2-nf-kb-hsa-mir-4282-route-in-osteoarthritis
#34
JOURNAL ARTICLE
Ko-Ta Chen, Chi-Tai Yeh, Vijesh Kumar Yadav, Narpati Wesa Pikatan, Iat-Hang Fong, Wei-Hwa Lee, Yen-Shuo Chiu
OBJECTIVE: Osteoarthritis (OA), the most prevalent form of arthritis, impacts approximately 10% of men and 18% of women aged above 60 years. Currently, a complete cure for OA remains elusive, making clinical management challenging. The traditional Chinese herb Notopterygium incisum , integral to the Juanbi pill for rheumatism, shows promise in safeguarding chondrocytes through its strong anti-inflammatory effects. METHODS: To explore the protective effect of notopterol and miRNA (has-miR-4248) against inflammation, we simulated an inflammatory environment in chondrocytes cell lines C20A4 and C28/12, focusing on inflammasome formation and pyroptosis...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532884/0-263-terahertz-irradiation-induced-genes-expression-changes-in-caenorhabditis-elegans
#35
JOURNAL ARTICLE
Sen Shang, Fei Gao, Qi Zhang, Tao Song, Wei Wang, Diwei Liu, Yubin Gong, Xiaoyun Lu
The biosafety of terahertz (THz) waves has emerged as a new area of concern with the gradual application of terahertz radiation. Even though many studies have been conducted to investigate the influence of THz radiation on living organisms, the biological effects of terahertz waves have not yet been fully revealed. In this study, Caenorhabditis elegans ( C. elegans ) was used to evaluate the biological consequences of whole-body exposure to 0.263 THz irradiation. The integration of transcriptome sequencing and behavioral tests of C...
April 19, 2024: IScience
https://read.qxmd.com/read/38532690/value-based-proposition-of-an-adapted-integrated-care-telehealth-service-for-accountable-care-organization-members
#36
JOURNAL ARTICLE
Jay Shore, Maryann Waugh, Justin Harding, George Roupas, Neil Pepi, Peter Ryan
The authors describe a real-world application of virtually integrated primary and behavioral health care implemented within an accountable care organization (ACO) system. Cost-of-care data from before and after a 6-month intervention were analyzed for 121 Medicaid and Child Health Plan Plus ACO members. The intervention was associated with a significant shift in the distribution of health care costs, from inpatient and emergency care to outpatient and preventive care. The program demonstrates a flexible and replicable approach to integration that can help expand effective primary care...
March 27, 2024: Psychiatric Services: a Journal of the American Psychiatric Association
https://read.qxmd.com/read/38532688/board-certified-psychiatric-pharmacists-and-their-potential-role-in-addressing-behavioral-health-workforce-shortages
#37
JOURNAL ARTICLE
Carla D Cobb, Talia Puzantian, Michael Shuman
Board-certified psychiatric pharmacists (BCPPs) are doctorate-level, board-certified experts in managing medications for people living with psychiatric disorders, including substance use disorders. BCPPs work as part of an integrated health care team that provides comprehensive medication management focused on optimizing medication-related outcomes and ensuring the safety of the prescribed medications. The authors describe BCPP education and training, settings in which BCPPs practice, and in what roles. Current policies that limit BCPP involvement in behavioral health care and proposed solutions to support the role of BCPPs in addressing behavioral health workforce shortages are discussed...
March 27, 2024: Psychiatric Services: a Journal of the American Psychiatric Association
https://read.qxmd.com/read/38532686/the-importance-of-autonomy-and-performance-goals-in-perceived-workload-among-behavioral-health-providers
#38
JOURNAL ARTICLE
Jennifer Burgess, Hyungjin Myra Kim, Brittany R Porath, Tony Van, Katerine Osatuke, Matthew Boden, Rebecca K Sripada, Edwin S Wong, Kara Zivin
OBJECTIVE: The authors sought to assess workplace characteristics associated with perceived reasonable workload among behavioral health care providers in the Veterans Health Administration. METHODS: The authors evaluated perceived reasonable workload and workplace characteristics from the 2019 All Employee Survey (AES; N=14,824) and 2019 Mental Health Provider Survey (MHPS; N=10,490) and facility-level staffing ratios from Mental Health Onboard Clinical Dashboard data...
March 27, 2024: Psychiatric Services: a Journal of the American Psychiatric Association
https://read.qxmd.com/read/38532674/-applying-problem-behavior-theory-to-investigate-the-factors-affecting-tobacco-products-use-by-students-at-eight-universities-in-the-greater-taipei-area
#39
JOURNAL ARTICLE
Yun-Xuan Zheng, Pei-Ching Chen
BACKGROUND: There is growing concern related to the recent rise in consumption of cigarettes, electronic cigarettes, and heated tobacco products. The government should pay more attention to the use of various tobacco products by university students. PURPOSE: Problem behavior theory was used in this study to explore the factors influencing the use of various tobacco products by university students in the Greater Taipei area. METHODS: In this cross-sectional study, convenience sampling was used to select eight institutions of higher education in the Greater Taipei area...
April 2023: Hu Li za Zhi the Journal of Nursing
https://read.qxmd.com/read/38532668/-embracing-the-era-of-artificial-intelligence-innovation-and-preparation-in-nursing-education
#40
JOURNAL ARTICLE
Su-Fen Cheng
Rapid recent advances in information technology have opened the door for artificial intelligence (AI)-related technologies to be applied extensively across many industries. The Ministry of Education has emphasized the importance of cultivating advanced-level professionals in diverse fields, particularly in smart machinery, the Asia-Silicon Valley sector, green energy technology, biotechnology, national defense, new agricultural, and circular economy industries, to enhance innovation and promote industrial competitiveness (Kuo, 2019)...
April 2024: Hu Li za Zhi the Journal of Nursing
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