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https://www.readbyqxmd.com/read/29334188/soft-artificial-bladder-detrusor
#1
Xuxu Yang, Chengrui An, Shuting Liu, Tingyu Cheng, Varitsara Bunpetch, Yixiao Liu, Shurong Dong, Shijian Li, Xiaohui Zou, Tiefeng Li, Hongwei Ouyang, Zhaohui Wu, Wei Yang
Developing soft devices for invasive procedures bears great importance for human health. The softness and large strain actuation of responsive hydrogels promise the potential to fabricate soft devices, which can attach on and assist to the function of organs. The key challenges lie in the fabrication of soft devices with robust actuating ability and biocompatibility to the attached organ. This paper presents a solution that integrates the thermoresponsive hydrogel membrane with flexible electronics and silk scaffold into a balloon-like soft device...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29333480/gpu-based-branchless-distance-driven-projection-and-backprojection
#2
Rui Liu, Lin Fu, Bruno De Man, Hengyong Yu
Projection and backprojection operations are essential in a variety of image reconstruction and physical correction algorithms in CT. The distance-driven (DD) projection and backprojection are widely used for their highly sequential memory access pattern and low arithmetic cost. However, a typical DD implementation has an inner loop that adjusts the calculation depending on the relative position between voxel and detector cell boundaries. The irregularity of the branch behavior makes it inefficient to be implemented on massively parallel computing devices such as graphics processing units (GPUs)...
December 2017: IEEE Transactions on Computational Imaging
https://www.readbyqxmd.com/read/29332992/experiment-design-for-early-molecular-events-in-hiv-infection
#3
Aditya Jagarapu, LaMont Cannon, Ryan Zurakowski
The recent introduction of integrase inhibitors to the HIV antiviral repertoire permits us to create in vitro experiments that reliably terminate HIV infection at the point of chromosomal integration. This allows us to isolate the dynamics of a single round of infection, without needing to account for the influence of multiple overlapping rounds of infection. By measuring the various nucleic acid concentrations in a population of infected target cells at multiple time points, we can infer the rates of these molecular events with great accuracy, which allows us to compare the rates between target cells with different functional phenotypes...
May 2017: Proceedings of the ... American Control Conference
https://www.readbyqxmd.com/read/29332511/the-process-of-primary-desistance-from-intimate-partner-violence
#4
Kate Walker, Erica Bowen, Sarah Brown, Emma Sleath
This study examined the interaction between structure and agency for individuals in the first or early phase of primary desistance (1 year offending free) from intimate partner violence (IPV). Narrative accounts of perpetrators, survivors, and IPV program facilitators were analyzed using Thematic Analysis. Changes in the self and the contexts, structures, and conditions were necessary to promote desistance. Perpetrators made behavioral and cognitive changes taking on different identities (agentic role) by removing external stressors and instability within the confines of a supportive environment (structural role)...
August 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29332263/creating-a-primary-care-workforce-strategies-for-leaders-clinicians-and-nurses
#5
Patricia Robinson, Julie Oyemaja, Bridget Beachy, Jeff Goodie, Lisa Sprague, Jennifer Bell, Mike Maples, Christy Ward
Many primary care clinics struggle with rapid implementation and systematic expansion of primary care behavioral health (PCBH) services. Often, an uneven course of program development is due to lack of attention to preparing clinic leadership, addressing operational factors, and training primary care providers (PCPs) and nurses. This article offers competency tools for clinic leaders, PCPs, and nurses to use in assessing their status and setting change targets. These tools were developed by researchers working to disseminate evidence-based interventions in primary care clinics that included fully integrated behavioral health consultants and were then used by early adaptors of the PCBH model...
January 13, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29331859/development-of-a-method-to-determine-axitinib-lapatinib-and-afatinib-in-plasma-by-micellar-liquid-chromatography-and-validation-by-the-european-medicines-agency-guidelines
#6
Jaume Albiol-Chiva, Josep Esteve-Romero, Juan Peris-Vicente
A method based on micellar liquid chromatography to quantify the tyrosine kinase inhibitors axitinib, lapatinib and afatinib in plasma is reported. The sample pretreatment was a simple 1/5-dilution in a pure micellar solution, filtration and direct injection, without requiring extraction or purification steps. The three drugs were resolved from the matrix in 17min, using an aqueous solution of 0.07M sodium dodecyl sulfate - 6.0% 1-pentanol, buffered at pH7 with 0.01M phosphate salt as mobile phase, running under isocratic mode at 1mL/min through a C18 column...
January 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29331709/what-do-the-genetic-association-data-say-about-the-high-risk-of-suicide-in-people-with-depression-a-novel-network-based-approach-to-find-common-molecular-basis-for-depression-and-suicidal-behavior-and-related-therapeutic-targets
#7
Ali Bozorgmehr, Fatemeh Alizadeh, Sattar Norouzi Ofogh, Mohammad Reza Abdollahzadeh Hamzekalayi, Sara Herati, Atefeh Moradkhani, Ali Shahbazi, Mohammad Ghadirivasfi
BACKGROUND: Available sources indicate that the risk of suicide in people with major depression is higher than other psychiatric disorders. Although it seems that these two conditions may have a shared cause in some cases, no studies have been conducted to identify a common basis for them. METHODS: In this study, following an extensive review of literature, we found almost all the genes that are involved in major depression and suicidal behavior, and we isolated genes shared between the two conditions...
January 8, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29331447/sharp-wave-ripples-as-a-signature-of-hippocampal-prefrontal-reactivation-for-memory-during-sleep-and-waking-states
#8
Wenbo Tang, Shantanu P Jadhav
It is widely believed that memories that are encoded and retrieved during waking behavior are consolidated during sleep. Recent studies on the interactions between the hippocampus and the prefrontal cortex have greatly advanced our understanding of the physiological bases of these memory processes. Although hippocampal-prefrontal network activity differs in many aspects during waking and sleep states, here we review evidence that hippocampal sharp-wave ripples (SWRs) emerge as a common neurophysiological pattern in both states, facilitating communication between these two regions via coordinated reactivation of stored memory information...
January 10, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29331276/analyzing-recommender-systems-for-health-promotion-using-a-multidisciplinary-taxonomy-a-scoping-review
#9
Santiago Hors-Fraile, Octavio Rivera-Romero, Francine Schneider, Luis Fernandez-Luque, Francisco Luna-Perejon, Anton Civit-Balcells, Hein de Vries
BACKGROUND: Recommender systems are information retrieval systems that provide users with relevant items (e.g., through messages). Despite their extensive use in the e-commerce and leisure domains, their application in healthcare is still in its infancy. These systems may be used to create tailored health interventions, thus reducing the cost of healthcare and fostering a healthier lifestyle in the population. OBJECTIVE: This paper identifies, categorizes, and analyzes the existing knowledge in terms of the literature published over the past 10 years on the use of health recommender systems for patient interventions...
December 28, 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29331232/incorporating-behavioral-and-sensory-context-into-spectro-temporal-models-of-auditory-encoding
#10
REVIEW
Stephen V David
For several decades, auditory neuroscientists have used spectro-temporal encoding models to understand how neurons in the auditory system represent sound. Derived from early applications of systems identification tools to the auditory periphery, the spectro-temporal receptive field (STRF) and more sophisticated variants have emerged as an efficient means of characterizing representation throughout the auditory system. Most of these encoding models describe neurons as static sensory filters. However, auditory neural coding is not static...
December 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/29330247/frequency-and-criticality-of-diagnoses-in-family-medicine-practices-from-the-national-ambulatory-medical-care-survey-namcs
#11
Michael R Peabody, Thomas R O'Neill, Keith L Stelter, James C Puffer
BACKGROUND: Family medicine is a specialty of breadth, providing comprehensive health care for the individual and the family that integrates the broad scope of clinical, social, and behavioral sciences. As such, the scope of practice (SOP) for family medicine is extensive; however, over time many family physicians narrow their SOP. We sought to provide a nationally representative description of the most common and the most critical diagnoses that family physicians see in their practice...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29330239/one-year-of-family-physicians-observations-on-working-with-medical-scribes
#12
Amelia Sattler, Tracy Rydel, Cathina Nguyen, Steven Lin
PURPOSE: The immense clerical burden felt by physicians is one of the leading causes of burnout. Scribes are increasingly being used to help alleviate this burden, yet few published studies investigate how scribes affect physicians' daily work, attitudes and behaviors, and relationships with patients and the workplace. METHODS: Using a longitudinal observational design, data were collected, over 1 year, from 4 physicians working with 2 scribes at a single academic family medicine practice...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29330054/deterministic-stability-regimes-and-noise-induced-quasistable-behavior-in-a-pair-of-reciprocally-inhibitory-neurons
#13
Mainak Patel, Badal Joshi
Reciprocal inhibition is a common motif exploited by neuronal networks; an intuitive and tractable way to examine the behaviors produced by reciprocal inhibition is to consider a pair of neurons that synaptically inhibit each other and receive constant or noisy excitatory driving currents. In this work, we examine reciprocal inhibition using two models (a voltage-based and a current-based integrate-and-fire model with instantaneous or temporally structured input), and we use analytic and computational tools to examine the bifurcations that occur and study the various possible monostable, bistable, and tristable regimes that can exist; we find that, depending on system parameters (and on choice of neuron model), there can exist up to 3 distinct monostable regimes (denoted M0, M1, M2), 3 distinct bistable regimes (denoted B, B1, B2), and a single tristable regime (denoted T)...
January 9, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29329978/data-quality-over-data-quantity-in-computational-cognitive-neuroscience
#14
Antonio Kolossa, Bruno Kopp
We analyzed factors that may hamper the advancement of computational cognitive neuroscience (CCN). These factors include a particular statistical mindset, which paves the way for the dominance of statistical power theory and a preoccupation with statistical replicability in the behavioral and neural sciences. Exclusive statistical concerns about sampling error occur at the cost of an inadequate representation of the problem of measurement error. We contrasted the manipulation of data quantity (sampling error, by varying the number of subjects) against the manipulation of data quality (measurement error, by varying the number of data per subject) in a simulated Bayesian model identifiability study...
January 9, 2018: NeuroImage
https://www.readbyqxmd.com/read/29328982/systematic-identification-of-suspected-anthelmintic-benzimidazole-metabolites-using-lc-ms-ms
#15
Marius Majewsky, David Castel, Ludivine Le Dret, Pascal Johann, David T Jones, Stefan M Pfister, Walter E Haefeli, J├╝rgen Burhenne
Metabolite reference standards are often not available, which results in a lack of MS/MS spectra for library matching. Consequently, the identification of suspected metabolites proves to be challenging. The present study aims at structurally elucidating the MS/MS fragmentation behavior of selected benzimidazole anthelmintics to theoretically predict characteristic product ions for rapid and systematic tentative metabolite identification. A set of common characteristic product ions was identified from accurate mass MS/MS experiments for five parent compounds...
December 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29328623/mimicking-biological-synaptic-functionality-with-an-indium-phosphide-synaptic-device-on-silicon-for-scalable-neuromorphic-computing
#16
Debarghya Sarkar, Jun Tao, Wei Wang, Qingfeng Lin, Matthew Yeung, Chenhao Ren, Rehan Kapadia
Neuromorphic or "brain-like" computation is a leading candidate for efficient, fault-tolerant processing of large-scale data, as well as real-time sensing and transduction of complex multivariate systems and networks such as self-driving vehicles or Internet of Things applications. In biology, the synapse serves as an active memory unit in the neural system, and is the component responsible for learning and memory. Electronically emulating this element via a compact, scalable technology which can be integrated in a 3-D architecture is critical for future implementations of neuromorphic processors...
January 12, 2018: ACS Nano
https://www.readbyqxmd.com/read/29327162/explication-of-a-behavioral-health-primary-care-integration-learning-collaborative-and-its-quality-improvement-implications
#17
Martha Okafor, Victor Ede, Rosemary Kinuthia, David Satcher
In an effort to tackle fragmented care in the US healthcare delivery system, we explored the use of learning collaborative (LC) to advance integration of behavioral health and primary care as one of the potential solutions to a holistic approach to the delivery of quality healthcare to individuals with physical and mental illness. How a diverse group of primary care and behavioral health providers formed a Community of Practice (CoP) with a common purpose and shared vision to advance integrated care using a LC approach is described...
January 11, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29326508/effect-of-ultraviolet-irradiation-on-the-osseointegration-of-a-titanium-alloy-with-bone
#18
Ashish Yadav, Ranjana Yadav, Aratee Gupta, Akash Baranwal, Atul Bhatnagar, Vakil Singh
Introduction: Attempt has been made to analyze the potential of titanium (Ti) alloy for osteointegration by the effect of surface photo functionalization in different aspects as follows: in Ringer's solution, in vitro cell growth, and in vivo study on rabbit. The present study was aimed to investigate the influence of ultraviolet (UV) light on surface topography, corrosion behavior, and bioactivity of indigenously manufactured samples of Ti alloy mini-implant. Materials and Methods: The study includes surface modification of Ti samples by UV treatment, corrosion testing of the specimens using Potentiostat (GAMRY System), qualitative examination of modified surface topography using scanning electron microscope, and cellular viability test on Ti alloy surface (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide ASSAY)...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326173/transcriptional-regulator-zeb2-is-essential-for-bergmann-glia-development
#19
Li He, Kun Yu, Fanghui Lu, Jiajia Wang, Laiman N Wu, Chuntao Zhao, Qianmei Li, Xianyao Zhou, Hanmin Liu, Dezhi Mu, Mei Xin, Mengsheng Qiu, Q Richard Lu
Bergmann glia facilitate granule neuron migration during development and maintain the cerebellar organization and functional integrity. At present, molecular control of Bergmann glia specification from cerebellar radial glia is not fully understood. In this report, we show that Zeb2 (a.k.a. Sip1 or Zfhx1b), a Mowat-Wilson-syndrome-associated transcriptional regulator, is highly expressed in Bergmann glia, but hardly detectable in astrocytes in the cerebellum. The mice lacking Zeb2 in cerebellar radial glia exhibit severe deficits in Bergmann glia specification, and develop cerebellar cortical lamination dysgenesis and locomotion defects...
January 11, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29326095/development-of-a-maternal-newborn-and-child-mhealth-intervention-in-thai-nguyen-province-vietnam-protocol-for-the-mmom-project
#20
Bronwyn McBride, Liem Thanh Nguyen, David Wiljer, Nguyen C Vu, Cuong K Nguyen, John O'Neil
BACKGROUND: Ethnic minority women (EMW) living in mountainous areas of northern Vietnam have disproportionately high infant and maternal mortality rates as a result of low maternal health knowledge, poverty, and remoteness from low-capacity health centers. OBJECTIVE: The objective of this study was to describe the protocol for the development and evaluation of the mMom intervention, which is an integrated mobile health (mHealth) system designed to improve maternal and infant health knowledge, and behavior among women in remote areas of Thai Nguyen, Vietnam...
January 11, 2018: JMIR Research Protocols
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