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Interleukin-6

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https://www.readbyqxmd.com/read/28445367/adipose-tissue-drives-response-to-ischemia-reperfusion-injury-in-a-murine-pressure-sore-model
#1
Madeleine J Gust, Seok Jong Hong, Robert C Fang, Steven T Lanier, Donald W Buck, Jennifer M Nuñez, Shengxian Jia, Eugene D Park, Robert D Galiano, Thomas A Mustoe
BACKGROUND: Ischemia-reperfusion injury contributes significantly to the pathogenesis of chronic wounds such as pressure sores and diabetic foot ulcers. The authors' laboratory has previously developed a cyclical murine ischemia-reperfusion injury model. The authors here use this model to determine factors underlying tissue response to ischemia-reperfusion injury. METHODS: C57BL/6 mice were subjected to cycles of ischemia-reperfusion that varied in number (one to four cycles) and duration of ischemia (1 to 2 hours)...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28445209/intelligence-and-interleukin-6-in-older-adults-the-role-of-repetitive-thought
#2
Suzanne C Segerstrom, Rebecca G Reed, April B Scott
OBJECTIVE: Higher IQ correlates with lower systemic inflammation, consistent with an association between lower IQ and disease risk. The present study examined the role of repetitive thought (RT) in the relationship between IQ and interleukin (IL)-6. RT is thinking attentively, repeatedly, and frequently about oneself and one's world and is characterized by Valence (positive-negative), Purpose (searching-solving), and Total quantity (much-little). METHODS: Estimated IQ and RT dimension scores were assessed at baseline in a sample of older adults (N=120, Mage=74 years), who thereafter had blood drawn up to 10 times semiannually (n=799)...
April 26, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28445093/dynamics-of-cytokine-like-activity-in-the-hyperplasic-ovary-of-ex-fissiparous-planarians
#3
Abdel Halim Harrath, Abdelhabib Semlali, Lamjed Mansour, Waleed Aldahmash, Suliman Y Al Omar, Mohamed S Al Anazi, Jens R Nyengaard, Saleh Alwasel
The origin of infertility in the hyperplasic ovary of ex-fissiparous planarians remains poorly understood. In a previous study we demonstrated that a complex process of early autophagy, followed by apoptotic processes, occurs in the hyperplasic ovary of the freshwater planarian Dugesia arabica. The present study aimed to investigate whether the mRNA expression levels of selected mRNA-like genes are altered in the hyperplasic ovary of the ex-fissiparous freshwater planarian D. arabica compared to the normal ovary...
February 2017: Biological Bulletin
https://www.readbyqxmd.com/read/28444964/randomized-clinical-trial-of-landiolol-hydrochloride-for-the-prevention-of-atrial-fibrillation-and-postoperative-complications-after-oesophagectomy-for-cancer
#4
T Ojima, M Nakamori, M Nakamura, M Katsuda, K Hayata, T Kato, J Kitadani, H Tabata, A Takeuchi, H Yamaue
BACKGROUND: Atrial fibrillation is common after oesophageal surgery. The aim of this study was to evaluate whether landiolol hydrochloride was effective and safe in the prevention of atrial fibrillation after oesophagectomy, and to see whether a reduction in incidence of atrial fibrillation would reduce other postoperative complications. METHODS: This single-centre study enrolled patients scheduled for transthoracic oesophagectomy in a randomized, double-blind, placebo-controlled trial between March 2013 and January 2016...
April 26, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28444107/apelin-13-inhibits-lipoprotein-lipase-expression-via-the-apj-pkc%C3%AE-mir-361-5p-signaling-pathway-in-thp-1-macrophage-derived-foam-cells
#5
Xin Zhang, Qiong Ye, Duo Gong, Yuan Lv, Haipeng Cheng, Chong Huang, Lingyan Chen, Zhenwang Zhao, Liang Li, Xie Wei, Min Zhang, Xiaodan Xia, Xiaohua Yu, Xilong Zheng, Shuzhi Wang, Zongbao Wang, Chaoke Tang
Atherosclerotic lesions are characterized by the accumulation of abundant lipids and chronic inflammation. Previous researches have indicated that macrophage-derived lipoprotein lipase (LPL) promotes atherosclerosis progression by accelerating lipid accumulation and pro-inflammatory cytokine secretion. Although apelin-13 has been regarded as an atheroprotective factor, it remains unclear whether it can regulate the expression of LPL. The aim of this study was to explore the effects of apelin-13 on the expression of LPL and the underlying mechanism in THP-1 macrophage-derived foam cells...
April 21, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28443823/gene-expression-oxidative-stress-and-apoptotic-changes-in-rabbit-ileum-experimentally-infected-with-eimeria-intestinalis
#6
Heba M Abdel-Haleem, Shawky M Aboelhadid, Thabet Sakran, Gamal El-Shahawy, Huda El-Fayoumi, Saleh Al-Quraishy, Abdel-Azeem S Abdel-Baki
Coccidiosis is a parasitic disease caused by protists (apicomplexans) of the genus Eimeria Schneider, 1875 and is considered to be the most important disease faced by rabbit breeders due to its high morbidity. In the present study, the antioxidant status and changes in apoptosis and in the expression of some genes were quantified in rabbits' ilea following infection with Eimeria intestinalis Cheissin, 1948. Rabbits, orally infected with 1 × 10(5) sporulated oocysts of E. intestinalis, started to shed oocysts in their faeces on 8 days post infection (dpi) and reached maximum excretion on 10 dpi, with approximately 5 million oocysts...
April 19, 2017: Folia Parasitologica
https://www.readbyqxmd.com/read/28442395/association-of-genetic-variations-in-il-6-il-6r-pathway-genes-with-gastric-cancer-risk-in-a-chinese-population
#7
Jian-Zhi Zhang, Chang-Ming Liu, Hui-Ping Peng, Ying Zhang
Interleukin-6 (IL-6) and its receptor (IL-6R) were regarded to be responsible for the occurrence of gastric cancer for their regulation roles in the inflammation. The genetic variations in these two genes (IL-6: rs6949149, rs1800796, rs10499563 and IL-6R:rs2228145) have been suggested to be associated with gastric cancer risk. However, the published results were inconsistent among subjects of different ethnicity. To evaluate such an association in Chinese population, we carried out this case-control study based on 473 patients with gastric cancer and 474 healthy controls, whose genotype were detected by the Sequenom MassARRAY platform, and Helicobacter pylori infection was assessed by immunogold testing kit...
April 22, 2017: Gene
https://www.readbyqxmd.com/read/28442260/synthesis-of-benzoxazole-derivatives-as-interleukin-6-antagonists
#8
Darong Kim, Hee Yeon Won, Eun Sook Hwang, Young-Kook Kim, Hea-Young Park Choo
A growing number of studies have demonstrated that interleukin (IL)-6 plays pathological roles in the development of chronic inflammatory disease and autoimmune disease by activating innate immune cells and by stimulating adaptive inflammatory T cells. So, suppression of IL-6 function may be beneficial for prevention and treatment of chronic inflammatory disease. This study reports that a series of synthetic derivatives of benzoxazole have suppressive effects on IL-6-mediated signaling. Among 16 synthetic derivatives of benzoxazole, the compounds 4, 6, 11, 15, 17, and 19 showed a strong suppressive activity against IL-6-induced phosphorylation of signal transducer and activator of transcription (STAT) 3 by 80-90%...
April 7, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28442041/cytokine-gene-expression-at-the-maternal-fetal-interface-after-somatic-cell-nuclear-transfer-pregnancies-in-small-ruminants
#9
Heloisa M Rutigliano, Amanda Wilhelm, Justin Hall, Bi Shi, Qinggang Meng, Rusty Stott, Thomas D Bunch, Kenneth L White, Christopher J Davies, Irina A Polejaeva
The present retrospective study investigated pregnancy rates, the incidence of pregnancy loss and large offspring syndrome (LOS) and immune-related gene expression of sheep and goat somatic cell nuclear transfer (SCNT) pregnancies. We hypothesised that significantly higher pregnancy losses observed in sheep compared with goat SCNT pregnancies are due to the increased amounts of T-helper 1 cytokines and proinflammatory mediators at the maternal-fetal interface. Sheep and goat SCNT pregnancies were generated using the same procedure...
April 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28441856/-clinical-value-of-the-early-use-of-ulinastatin-in-patients-with-moderately-severe-or-severe-acute-pancreatitis
#10
J Wang, J Jin, J Huang, D R Li, Y Hao, J D Kong, Z Y Chu, J H Fu, F Huang
Objective: To observe the clinical efficacy and the effects on serum inflammatory factors of early use of ulinastatin in patients with moderately severe or severe acute pancreatitis (MSAP/SAP). Methods: This prospective, randomized, controlled trial was conducted in the First Affiliated Hospital of Soochow University from September 2013 to May 2016. A total of 42 cases were enrolled and assigned into either observation group or conventional treatment group (n=21 each). The conventional treatment group received somatostatin, while the observation group received somatostatin combined with ulinastatin...
April 25, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28441756/the-interactions-between-zno-nanoparticles-nps-and-%C3%AE-linolenic-acid-lna-complexed-to-bsa-did-not-influence-the-toxicity-of-zno-nps-on-hepg2-cells
#11
Yiwei Zhou, Xin Fang, Yu Gong, Aiping Xiao, Yixi Xie, Liangliang Liu, Yi Cao
BACKGROUND: Nanoparticles (NPs) entering the biological environment could interact with biomolecules, but little is known about the interaction between unsaturated fatty acids (UFA) and NPs. METHODS: This study used α-linolenic acid (LNA) complexed to bovine serum albumin (BSA) for UFA and HepG2 cells for hepatocytes. The interactions between BSA or LNA and ZnO NPs were studied. RESULTS: The presence of BSA or LNA affected the hydrodynamic size, zeta potential, UV-Vis, fluorescence, and synchronous fluorescence spectra of ZnO NPs, which indicated an interaction between BSA or LNA and NPs...
April 24, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28440889/a-glucagon-like-peptide-1-analog-liraglutide-improves-visceral-sensation-and-gut-permeability-in-rats
#12
Tsukasa Nozu, Saori Miyagishi, Shima Kumei, Rintaro Nozu, Kaoru Takakusaki, Toshikatsu Okumura
BACKGROUND AND AIM: A glucagon-like peptide-1 (GLP-1) analog, liraglutide, has been reported to block inflammatory somatic pain. We hypothesized that liraglutide attenuates lipopolysaccharide (LPS)- and repeated water avoidance stress (WAS)-induced visceral hypersensitivity and tested the hypothesis in rats. METHODS: The threshold of the visceromotor response (VMR) induced by colonic balloon distention was measured to assess visceral sensation. Colonic permeability was determined in vivo by quantifying the absorbed Evans blue spectrophotometrically, which was instilled in the proximal colon for 15 min...
April 25, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28440766/unfavorable-cytokine-and-adhesion-molecule-profiles-during-and-after-pregnancy-in-women-with-gestational-diabetes-mellitus
#13
María Del Mar Roca-Rodríguez, Cristina López-Tinoco, Álvaro Fernández-Deudero, Mora Murri, María Victoria García-Palacios, María Del Amor García-Valero, Francisco José Tinahones, Manuel Aguilar-Diosdado
BACKGROUND: Gestational diabetes mellitus is a significant risk factor for metabolic syndrome and cardiovascular disease. AIMS: To assess the relationships between components of the metabolic syndrome and cytokine and adhesion molecule levels in women with GDM during pregnancy and after delivery. PATIENTS AND METHODS: A prospective case-control study on a sample of 126 pregnant women (63 with and 63 without gestational diabetes mellitus). In an intra-subject analysis, 41 women with history of gestational diabetes mellitus and 21 controls were re-assessed in the postpartum period...
January 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28440734/cholinergic-activation-suppresses-palmitate-induced-macrophage-activation-and-improves-acylation-stimulating-protein-resistance-in-co-cultured-adipocytes
#14
Jing Wu, Zhou-Yang Jiao, Rui-Zhen Li, Hui-Ling Lu, Hao-Hao Zhang, Katherine Cianflone
Acylation-stimulating protein (ASP), produced through activation of the alternative complement immune system, modulates lipid metabolism. Using a trans-well co-culture cell model, the mitigating role of α7-nicotinic acetylcholine receptor (α7nAChR)-mediated cholinergic pathway on ASP resistance was evaluated. ASP signaling in adipocytes via its receptor C5L2 and signaling intermediates Gαq, Gβ, phosphorylated protein kinase C-α, and protein kinase C-ζ were markedly suppressed in the presence of TNFα or medium from palmitate-treated RAW264...
May 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28440716/exercise-reduced-pentraxin-3-levels-produced-by-endotoxin-stimulated-human-peripheral-blood-mononuclear-cells-in-obese-individuals
#15
Aaron L Slusher, Yoshimi Shibata, Michael Whitehurst, Arun Maharaj, Justin M Quiles, Chun-Jung Huang
The purpose of this study was to determine whether obesity would reduce the capacity of peripheral blood mononuclear cells (PBMCs) to produce the anti-inflammatory protein pentraxin 3 (PTX3) in response to ex vivo stimulation with lipopolysaccharide (LPS), and if acute aerobic exercise would enhance this PTX3 production capacity. In addition, the inter-relationships of LPS-induced PTX3 with the inflammatory cytokines (interleukin 6 [IL-6], IL-10, and tumor necrosis factor alpha) were examined. Twenty-one healthy subjects (10 obese and 11 normal-weight) performed an acute bout of aerobic exercise at 75% VO2max...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28440694/fine-particulate-matter-pm2-5-a-risk-factor-of-rat-gestational-diabetes-with-altered-blood-glucose-and-pancreatic-glut2-expression
#16
Liu Yi, Chen Wei, Wang Fan
Recent studies have shown an association between air pollution and diabetic risk. This study was to investigate the impact of fine particulate matter (PM2.5) on glucose consequences and pancreas glucose transporter 2 (GLUT2) expression and its related mechanisms in a gestational diabetes mellitus (GDM) rat model. GDM rats were exposed to a low PM2.5 dose while the controls received saline. Interleukin-6 (IL-6) and blood routine tests (BRT) were detected for analyzing coagulation and inflammation. Pancreas tissues underwent pathologic examination, the levels of homogenate glutathione peroxidase (GSH-Px), and methane dicarboxylic aldehyde (MDA) were detected for oxidative stress estimation, and the degree of GLUT2 expression of pancreas was analyzed...
April 25, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28440487/interaction-between-interleukin%C3%A2-6-and-angiotensin-ii-receptor-1-in-the-hypothalamic-paraventricular-nucleus-contributes-to-progression-of-heart-failure
#17
Tao Wang, Wen Gao, Kun Xiao, Qiang Liu, Ruyi Jia
The association between interleukin‑6 (IL‑6) and angiotensin II receptor 1 (AT1‑R) in modulating the progression of heart failure (HF) remains to be fully elucidated. The aim of the present study was to investigate the mechanism of IL‑6 and AT1‑R in a model of HF induced by surgery. Male Sprague‑Dawley rats were randomly divided into five groups, including sham surgery and vehicle groups. The animals were treated for 4 weeks via paraventricular nucleus infusion with either vehicle, losartan (LOS; 200 µg/day), IL‑6 (1 µg/day) or LOS and IL‑6 together (LOS+IL‑6)...
April 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28440455/%C3%AE-adrenoceptor-mediated-enhanced-inducibility-of-atrial-fibrillation-in-a-canine-system-inflammation-model
#18
Ying-Ying Chen, Ze-Wei Sun, Jian-Ping Jiang, Xiao-Dong Kang, Lin-Lin Wang, Yue-Liang Shen, Xu-Dong Xie, Liang-Rong Zheng
The exact mechanism associated with inflammation and atrial fibrillation (AF) remains unknown. The aim of the present study was to investigate the roles of connexin 43 (Cx43) and a1‑adrenergic receptor (α1‑AR) activation in the pathogenesis of system inflammation‑induced AF. A canine model of chronic low‑grade system inflammation was established by administrating a low dose of lipopolysaccharide (LPS; 0.1 µg/kg) for 2 weeks. Programmed stimulation was applied on the right atrial appendage to determine the effective refractory periods (ERP) and the window of vulnerability (WOV)...
April 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28440046/attenuated-low-grade-inflammation-following-long-term-dietary-intervention-in-postmenopausal-women-with-obesity
#19
Caroline Blomquist, Malin Alvehus, Jonas Burén, Mats Ryberg, Christel Larsson, Bernt Lindahl, Caroline Mellberg, Ingegerd Söderström, Elin Chorell, Tommy Olsson
OBJECTIVE: Abdominal fat accumulation after menopause is associated with low-grade inflammation and increased risk of metabolic disorders. Effective long-term lifestyle treatment is therefore needed. METHODS: Seventy healthy postmenopausal women (age 60 ± 5.6 years) with BMI 32.5 ± 5.5 were randomized to a Paleolithic-type diet (PD) or a prudent control diet (CD) for 24 months. Blood samples and fat biopsies were collected at baseline, 6 months, and 24 months to analyze inflammation-related parameters...
May 2017: Obesity
https://www.readbyqxmd.com/read/28438640/neutralizing-il-6-reduces-heart-injury-by-decreasing-nerve-growth-factor-precursor-in-the-heart-and-hypothalamus-during-rat-cardiopulmonary-bypass
#20
Chi Cheng, Jun-Mei Xu, Tian Yu
AIMS: To investigate whether the expression of nerve growth factor precursor (proNGF) changes during cardiopulmonary bypass (CPB) and whether neutralizing interleukin-6 (IL-6) during CPB has cardiac benefits. MAIN METHODS: Thirty patients undergoing CPB were recruited and their serum proNGF and troponin-I (TNI) were detected. In addition, rats were divided into three groups: CPB group, CPB with cardiac ischemia-reperfusion (IR) group, and a control group. The pre-CPB standard deviation of N-N intervals (SDNN) and post-CPB SDNN were compared...
April 21, 2017: Life Sciences
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