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https://www.readbyqxmd.com/read/28239809/association-between-the-plasma-levels-of-ima-and-coronary-atherosclerotic-plaque-burden-and-ischemic-burden-in-early-phase-of-non-st-segment-elevation-acute-coronary-syndromes
#1
T Turan, A R Akyüz, S Sahin, S Kul, A S Yilmaz, F Kara, S O Mentese, A Ç Aykan, S Demir, S Celik, S C Karahan
OBJECTIVE: Ischemia-modified albumin (IMA), a novel biochemical marker, is known to reflect ischemia in early phases of acute coronary syndrome (ACS). In the present study, we evaluated the role of IMA on the prediction of coronary atherosclerotic plaque burden and ischemic burden in patients with non-ST-segment-elevation acute coronary syndromes (NSTEACS). PATIENTS AND METHODS: Ninety-six consecutive NSTEACS patients presented within the first three hours of symptom onset were prospectively enrolled in this study...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28239633/dataset-of-proinflammatory-cytokine-and-cytokine-receptor-gene-expression-in-rainbow-trout-oncorhynchus-mykiss-measured-using-a-novel-gexp-multiplex-rt-pcr-assay
#2
Ivan Kutyrev, Beth Cleveland, Timothy Leeds, Gregory D Wiens
A GeXP multiplex, RT-PCR assay was developed and optimized that simultaneously measures expression of a suite of immune-relevant genes in rainbow trout (Oncorhynchus mykiss), concentrating on tumor necrosis factor and interleukin-1 ligand/receptor systems and acute phase response genes. The dataset includes expression values for drpt, il11a, il1b1, il1b2, il1b3, il1r-like-1(e3-5), il1r-like-1(e9-11), il1r1-like-a, il1r1-like-b, il1r2, saa, tnfa1, tnfa2, tnfa3, tnfrsf1a, tnfrsf1a-like-a, tnfrsf1a-like-b, tnfrsf5, and tnfrsf9...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28239513/rapid-molecular-detection-of-zika-virus-in-acute-phase-urine-samples-using-the-recombinase-polymerase-amplification-assay
#3
Ahmed Abd El Wahed, Sabri Saeed Sanabani, Oumar Faye, Rodrigo Pessôa, João Veras Patriota, Ricardo Rodrigues Giorgi, Pranav Patel, Susanne Böhlken-Fascher, Olfert Landt, Matthias Niedrig, Paolo Marinho de Andrade Zanotto, Claus Peter Czerny, Amadou A Sall, Manfred Weidmann
BACKGROUND: Currently the detection of Zika virus (ZIKV) in patient samples is done by real-time RT-PCR. Samples collected from rural area are sent to highly equipped laboratories for screening. A rapid point-of-care test is needed to detect the virus, especially at low resource settings. METHODOLOGY/PRINCIPAL FINDINGS: In this report, we describe the development of a reverse transcription isothermal recombinase polymerase amplification (RT-RPA) assay for the identification of ZIKV...
January 25, 2017: PLoS Currents
https://www.readbyqxmd.com/read/28239380/development-of-three-different-nk-cell-subpopulations-during-immune-reconstitution-after-pediatric-allogeneic-hematopoietic-stem-cell-transplantation-prognostic-markers-in-gvhd-and-viral-infections
#4
Sabine Huenecke, Claudia Cappel, Ruth Esser, Verena Pfirrmann, Emilia Salzmann-Manrique, Sibille Betz, Eileen Keitl, Julia Banisharif-Dehkordi, Shahrzad Bakhtiar, Christoph Königs, Andrea Jarisch, Jan Soerensen, Evelyn Ullrich, Thomas Klingebiel, Peter Bader, Melanie Bremm
Natural killer (NK) cells play an important role following allogeneic hematopoietic stem cell transplantation (HSCT) exerting graft-versus-leukemia/tumor effect and mediating pathogen-specific immunity. Although NK cells are the first donor-derived lymphocytes reconstituting post-HSCT, their distribution of CD56(++)CD16(-) (CD56(bright)), CD56(++)CD16(+) (CD56(intermediate=int)), and CD56(+)CD16(++) (CD56(dim)) NK cells is explicitly divergent from healthy adults, but to some extent comparable to the NK cell development in early childhood...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28239339/microarray-and-qpcr-analyses-of-wallerian-degeneration-in-rat-sciatic-nerves
#5
Sheng Yi, Xin Tang, Jun Yu, Jie Liu, Fei Ding, Xiaosong Gu
Wallerian degeneration occurs immediately following injury to mammal peripheral nerves. To better understand the molecular events occurring during Wallerian degeneration, a rat model of sciatic nerve transection was used to assess differentially expressed genes at 0.5, 1, 6, 12, 24 h, 4 days, 1, 2, 3, and 4 weeks post nerve injury (PNI). Hierarchical clustering, Euclidean distance matrix, and principal component analysis (PCA) collectively suggested three distinct phases within the post-injury period of 4 weeks...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28239141/chronic-myeloid-leukemia-associated-hypercalcemia-a-case-report-and-literature-review
#6
David Toro-Tobón, Sarimar Agosto, Sara Ahmadi, Maureen Koops, Jan M Bruder
BACKGROUND Hypercalcemia associated with chronic myeloid leukemia (CML) is an ominous sign. Although rare, several cases have been reported and multiple pathophysiologic mechanisms have been independently proposed. We present a patient case and a literature review of the clinical presentation and mechanisms of CML-associated hypercalcemia. CASE REPORT A 58-year-old male with a past medical history of CML diagnosed six years earlier, presented to the emergency department with one week of acute confusion, disorientation, polyuria, and polydipsia...
February 27, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28239036/short-term-subcutaneous-fondaparinux-and-oral-edoxaban-for-acute-venous-thromboembolism
#7
Shinji Hisatake, Takayuki Kabuki, Shunsuke Kiuchi, Takashi Oka, Shintaro Dobashi, Takahiro Fujii, Yoshihiro Iwasaki, Takanori Ikeda
BACKGROUND: No studies have compared treatment efficacy between subcutaneous (SC) fondaparinux and oral edoxaban, which are categorized as factor Xa inhibitors, for venous thromboembolism (VTE) in the acute phase, and only a limited number of imaging-based quantitative studies have evaluated treatment.Methods and Results:In this open-label, randomized study, 50 patients with acute non-massive pulmonary embolism (PE) and/or deep-vein thrombosis (DVT) were assigned to fondaparinux or edoxaban groups...
February 25, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28238923/outcome-after-endovascular-repair-of-subacute-type-b-aortic-dissection-a-combined-series-from-two-greek-centers
#8
Nikolaos Asaloumidis, Christos D Karkos, Georgios Trellopoulos, Konstantinos Konstantinidis, Ioakeim T Giagtzidis, Thomas E Kalogirou, Konstantinos O Papazoglou
AIM: To document the outcome following endovascular treatment of subacute type B aortic dissection (AD). METHODS: Between October 2000 and June 2014, 40 patients (33 men, mean age 65 [range 35-87] years) with type B AD underwent thoracic endovascular aortic repair (TEVAR) during the subacute phase (defined as 15-90 days from the onset of symptoms). Indications for intervention were acute aortic enlargement, resistant hypertension and/or intractable pain. The primary outcome was survival...
February 23, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28238905/seasonal-heat-stress-affects-adipose-tissue-proteome-toward-enrichment-of-the-nrf2-mediated-oxidative-stress-response-in-late-pregnant-dairy-cows
#9
M Zachut, G Kra, L Livshitz, Y Portnick, S Yakoby, G Friedlander, Y Levin
: Environmental heat stress and metabolic stress during transition from late gestation to lactation are main factors limiting production in dairy cattle, and there is a complex interaction between them. Many proteins expressed in adipose tissue are involved in metabolic responses to stress. We aimed to investigate the effects of seasonal heat stress on adipose proteome in late-pregnant cows, and to identify biomarkers of heat stress. Late pregnant cows during summer heat stress (S, n=18), or during the winter season (W, n=12) were used...
February 23, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28238903/responsiveness-to-bronchodilator-procaterol-in-copd-as-assessed-by-forced-oscillation-technique
#10
Satoru Ito, Akemi Uchida, Yoshitaka Isobe, Yoshinori Hasegawa
The aim of this retrospective study was to assess responses to a bronchodilator by forced oscillation technique (FOT) and to relate the results of respiratory impedance (Zrs) to spirometric parameters in patients with chronic obstructive pulmonary disease (COPD). Zrs was measured as a function of frequency from 4 to 36Hz before and after inhalation of procaterol, a short-acting β2-agonist (n=60). Respiratory resistance (Rrs) and reactance (Xrs) were significantly frequency-dependent, and inspiratory and expiratory phases were different both before and after procaterol inhalation...
February 23, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28238190/effects-of-6%C3%A2-months-of-resveratrol-versus-placebo-on-pentraxin-3-in-patients-with-type-2-diabetes-mellitus-a-double-blind-randomized-controlled-trial
#11
S Bo, V Ponzo, A Evangelista, G Ciccone, I Goitre, F Saba, M Procopio, M Cassader, R Gambino
AIMS: The anti-inflammatory effects of the polyphenol resveratrol in patients with type 2 diabetes mellitus (T2DM) are controversial. Its role on pentraxin 3 (PTX3) concentrations, a human acute phase protein, has never been evaluated. Our aim was to determine whether a two-dosage resveratrol supplementation (500 and 40 mg/day) has an impact on PTX3 values in T2DM patients from a double-blind randomized placebo-controlled trial. Variations in total antioxidant status (TAS) were evaluated too...
February 25, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28238152/myocardial-infarction-in-neonates-a-review-of-an-entity-with-significant-morbidity-and-mortality
#12
REVIEW
Koyelle Papneja, Anthony K Chan, Tapas K Mondal, Bosco Paes
Coronary artery disease is a global problem with high mortality rates and significant residual sequelae that affect long-term quality of life. Myocardial infarction (MI) in neonates is a recognized, uncommon entity, but the incidence and broad spectrum of the disease is unknown and likely underestimated due to limited reporting which in the majority is confined to acute ischemic events. The challenges involve clinical diagnosis which masquerades in the early phase as non-specific symptoms and signs that are commonly found in a host of neonatal disorders...
February 25, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28237481/20-hydroxyecdysone-from-dacrycarpus-imbricatus-bark-inhibits-the-proliferation-of-acute-myeloid-leukemia-cells
#13
Trinh Thi Thuy, Nguyen Thanh Tam, Nguyen Thi Hoang Anh, Dang Viet Hau, Dinh Thi Phong, Le Quoc Thang, Sabrina Adorisio, Tran Van Sung, Domenico V Delfino
OBJECTIVE: To investigate the anti-proliferative effects of 20-hydroxyecdysone isolated from the bark of Dacrycarpus imbricatus (Blume) de Laub. METHODS: Column chromatography was used for isolation of compounds from plant material. The structure of the isolated compound was identified by mass spectrometry and nuclear magnetic resonance techniques, including HSQC, HMBC, NOE-difference experiments. The isolated compound was tested for its anti-proliferative activity in acute myeloid leukemia (AML) and OCI-AML cells...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28237416/the-combined-effects-of-menstrual-cycle-phase-and-acute-stress-on-reward-related-processing
#14
Stella Banis, Monicque M Lorist
We investigated the combined effects of menstrual cycle phase and acute stress on reward-related processing, employing a monetary incentive delay task in combination with EEG. Females participated during late follicular and late luteal phases, performing in both control and stress conditions. We found evidence for both independent and interaction effects of phase and stress on reward-related brain activity. Phase modulated the sensitivity to feedback valence, with a stronger signaling of negative performance outcomes in the late follicular versus late luteal phase...
February 22, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28236991/-how-to-assess-curative-and-or-preventive-effects-of-psychotropic-drugs
#15
T Bottai, D Pringuey, R Belzeaux, M Adida, J-M Azorin
Proving the efficacy of a psychotropic drug is a medical, scientific and ethical need. Psychotropic drug development is now a highly complex process, which takes several years and which is very expensive. It involves multiple steps of preclinical and clinical pharmacological refinement and testing. Methodology of studies to prove curative or preventive effect of psychotropic drugs is well codified. Preclinical studies include pharmacokinetic data, toxicology and performance in various animal models of pathology...
December 2016: L'Encéphale
https://www.readbyqxmd.com/read/28236536/-streptococcus-milleri-an-unusual-cause-of-skull-extensive-osteomyelitis-in-an-immunocompetent-patient
#16
C Duquenne, E Dernis, A Zehrouni, A Bizon, M Duquenne
INTRODUCTION: Streptococcus milleri (Streptococcus anginosus, intermedius and constellatus) are commensal organisms, which can become pathogenic and cause infection with frequent abscess formation, local or metastatic extension. Osteomyelitis of the skull has been rarely reported in this type of infection. CASE REPORT: Skull osteomyelitis due to Streptococcus milleri is reported in a 61-year-old immunocompetent man without any medical history, occurring 10 months after a head injury without any wound or complication at initial presentation...
February 21, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28236162/regression-and-complications-of-z-score-based-giant-aneurysms-in-a-dutch-cohort-of-kawasaki-disease-patients
#17
S M Dietz, I M Kuipers, J C D Koole, J M P J Breur, Z Fejzic, S Frerich, M Dalinghaus, A A W Roest, B A Hutten, T W Kuijpers
: Kawasaki disease (KD) is a pediatric vasculitis. Its main complication is the development of coronary artery aneurysms (CAA), with giant CAA at the end of the spectrum. We evaluated regression and event-free rates in a non-Asian cohort of patients with giant CAA using the current z-scores adjusted for body surface area instead of absolute diameters. KD patients with giant CAA (z-score ≥10) visiting our outpatient clinic between January 1999 and September 2015 were included. Patient characteristics and clinical details were extracted from medical records...
February 24, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28235817/intracerebral-hemorrhage-location-and-outcome-among-interact2-participants
#18
Candice Delcourt, Shoichiro Sato, Shihong Zhang, Else Charlotte Sandset, Danni Zheng, Xiaoying Chen, Maree L Hackett, Hisatomi Arima, Jun Hata, Emma Heeley, Rustam Al-Shahi Salman, Thompson Robinson, Leo Davies, Pablo M Lavados, Richard I Lindley, Christian Stapf, John Chalmers, Craig S Anderson
OBJECTIVE: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). METHODS: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. RESULTS: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2...
February 24, 2017: Neurology
https://www.readbyqxmd.com/read/28235787/evaluation-of-a-rapid-igm-detection-test-for-diagnosis-of-acute-leptospirosis-in-dogs
#19
J Lizer, M Grahlmann, H Hapke, S Velineni, D Lin, B Kohn
Recently, a lateral flow assay (LFA) for detection of Leptospira-specific IgM in canine sera became commercially available in Europe. The present study aims to evaluate the diagnostic performance of this assay using canine sera from a collection of diagnostic accessions. Diagnostic sensitivity was assessed by testing 37 acute-phase and 9 corresponding convalescent-phase sera from dogs with a confirmed diagnosis of leptospirosis. Specificity was determined by testing sera from sick dogs with non-leptospiral infections (n=15) and healthy dogs with incomplete history of vaccination (n=45)...
February 24, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28235771/dynamics-of-myeloid-cell-populations-during-relapse-preventive-immunotherapy-in-acute-myeloid-leukemia
#20
Anna Rydström, Alexander Hallner, Johan Aurelius, Frida Ewald Sander, Elin Bernson, Roberta Kiffin, Fredrik Bergh Thoren, Kristoffer Hellstrand, Anna Martner
Relapse of leukemia in the postchemotherapy phase contributes to the poor prognosis and survival in patients with acute myeloid leukemia (AML). In an international phase IV trial (ClinicalTrials.gov; NCT01347996), 84 patients with AML in first complete remission who had not undergone transplantation received immunotherapy with histamine dihydrochloride (HDC) and low-dose IL-2 with the aim of preventing relapse. The dynamics of myeloid cell counts and expression of activation markers was assessed before and after cycles of immunotherapy and correlated with clinical outcome in terms of relapse risk and survival...
February 24, 2017: Journal of Leukocyte Biology
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