Kanta Chandwe, Mutsa Bwakura-Dangarembizi, Beatrice Amadi, Gertrude Tawodzera, Deophine Ngosa, Anesu Dzikiti, Nivea Chulu, Robert Makuyana, Kanekwa Zyambo, Kuda Mutasa, Chola Mulenga, Ellen Besa, Jonathan P Sturgeon, Shepherd Mudzingwa, Bwalya Simunyola, Lydia Kazhila, Masuzyo Zyambo, Hazel Sonkwe, Batsirai Mutasa, Miyoba Chipunza, Virginia Sauramba, Lisa Langhaug, Victor Mudenda, Simon H Murch, Susan Hill, Raymond J Playford, Kelley VanBuskirk, Andrew J Prendergast, Paul Kelly
Malnutrition underlies almost half of all child deaths globally. Severe Acute Malnutrition (SAM) carries unacceptable mortality, particularly if accompanied by infection or medical complications, including enteropathy. We evaluated four interventions for malnutrition enteropathy in a multi-centre phase II multi-arm trial in Zambia and Zimbabwe and completed in 2021. The purpose of this trial was to identify therapies which could be taken forward into phase III trials. Children of either sex were eligible for inclusion if aged 6-59 months and hospitalised with SAM (using WHO definitions: WLZ <-3, and/or MUAC <11...
April 17, 2024: Nature Communications