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https://www.readbyqxmd.com/read/29913299/pharmacological-and-toxicological-study-of-a-chemical-standardized-ethanol-extract-of-the-branches-and-leaves-from-eysenhardtia-polystachya-ortega-sarg-fabaceae
#1
Angel Josabad Alonso-Castro, Juan Ramón Zapata-Morales, Victor Arana-Argáez, Julio Cesar Torres-Romero, Eyra Ramírez-Villanueva, Sabino Eduardo Pérez-Medina, Marco Antonio Ramírez-Morales, Mario Alberto Juárez-Méndez, Yessica Paola Infante-Barrios, Fidel Martínez-Gutiérrez, Candy Carranza-Álvarez, Mario Alberto Isiordia-Espinoza, Andrés Flores-Santos
Eysenhardtia polystachya is used for the empirical treatment of cancer, infections, diarrhea, inflammation, and pain. This study identified, using GC-MS, the main chemical components in an ethanol extract of E. polystachya branches and leaves (EPE) and tested its cytotoxic, antimicrobial, anti-diarrheal, anti-inflammatory, and antinociceptive effects. The in vitro and in vivo toxicity of EPE was evaluated using the comet assay in human peripheral blood mononuclear cells (PBMC) and the acute toxicity test in mice, respectively...
June 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29913254/patient-reported-outcomes-in-nrg-oncology-rtog-0938-evaluating-two-ultrahypofractionated-regimens-for-prostate-cancer
#2
Himanshu R Lukka, Stephanie L Pugh, Deborah W Bruner, Jean-Paul Bahary, Colleen A F Lawton, Jason A Efstathiou, Rajat J Kudchadker, Lee E Ponsky, Samantha A Seaward, Ian S Dayes, Darindra D Gopaul, Jeff M Michalski, Guila Delouya, Irving D Kaplan, Eric M Horwitz, Mack Roach, Wayne H Pinover, David C Beyer, John O Amanie, Howard M Sandler, Lisa A Kachnic
BACKGROUND: There is considerable interest in very short (ultrahypofractionated) radiotherapy regimens to treat prostate cancer based on potential radiobiological advantages, patient convenience and resource allocation benefits. OBJECTIVE: To demonstrate that detectable changes in health related quality of life measured by the bowel and urinary domains of the Expanded Prostate Cancer Index Composite (EPIC-50) were not substantially worse than baseline. DESIGN, SETTING, AND PARTICIPANTS: XXXX is a non-blinded randomized phase II study of NCCN low risk prostate cancer where each arm is compared to a historical control...
June 15, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29913230/subjective-feelings-of-appetite-of-wholegrain-breakfasts-evaluated-under-controlled-laboratory-and-at-home-conditions
#3
Wilrike J Pasman, Henk F J Hendriks, Mans M Minekus, Rianne A F de Ligt, Maarten J Scholtes-Timmerman, Nard D S Clabbers, Nynke M Leonards, Jodee Johnson, Susann Bellmann
BACKGROUND: Appetite regulating properties of foods are usually investigated under laboratory conditions, whereas in real life, foods are consumed under at home conditions. The objective of this study was to compare the acute effects of breakfasts when tested in a laboratory condition and in an at home condition. Appetite regulating properties of two bread breakfasts and two cereal breakfasts were also compared. SUBJECTS AND METHODS: In this randomized cross-over trial balanced for laboratory and at home test conditions, thirty-two women consumed five breakfasts, i...
June 15, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29912932/openness-to-experience-and-stress-responsivity-an-examination-of-cardiovascular-and-underlying-hemodynamic-trajectories-within-an-acute-stress-exposure
#4
Páraic S O'Súilleabháin, Siobhán Howard, Brian M Hughes
The personality trait openness to experience has been implicated in health, and in particular cardiovascular wellbeing. In a sample of 62 healthy young female adults, the role of openness in cardiovascular responsivity during a stress exposure was examined. Traditionally, methodologies have averaged a stress exposure into a single reading. This may be limited in that it does not consider patterns of cardiovascular adaptation within a stress exposure. Continuous cardiovascular data were reduced to mean 10 second readings, with phases determined through examinations of shifts in responsivity between each 10 second pairing...
2018: PloS One
https://www.readbyqxmd.com/read/29912857/stretch-could-reduce-hamstring-injury-risk-during-sprinting-by-right-shifting-the-length-torque-curve
#5
Mianfang Ruan, Li Li, Chen Chen, Xie Wu
Ruan, M, Li, L, Chen, C, and Wu, X. Stretch could reduce hamstring injury risk during sprinting by right shifting the length-torque curve. J Strength Cond Res XX(X): 000-000, 2018-It was hypothesized that static stretch would shift the length-torque curve to the right, which may reduce the risk of muscle strain injuries. The purpose of this study was to evaluate the acute effects of static stretching of hamstring (SSH) on the risk of hamstring injury during sprinting indicated by the shift of the length-torque relationship...
June 15, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29912356/effects-of-a-saccharomyces-cerevisiae-fermentation-product-in-receiving-diets-of-newly-weaned-beef-steers-ii-digestibility-and-response-to-a-vaccination-challenge
#6
E L Deters, R S Stokes, O N Genther-Schroeder, S L Hansen
Thirty-six newly weaned, crossbred beef steers (323 ± 12 kg; SD) from a single-source were used in a 56-d study to examine the effects of a Saccharomyces cerevisiae fermentation product (SCFP; Original XPC, Diamond V, Cedar Rapids, IA) on total tract nutrient digestibility and response to a vaccination challenge. Twelve d after arrival, steers were blocked by body weight (BW) and randomly assigned to treatments: SCFP at 0 (CON), 14 (SCFP14), or 28 (SCFP28) g·steer-1·d-1. Steers were fed via bunks that measured individual intake and received ear tags (CowManager, Select Sires, Plain City, OH) that recorded rumination and activity...
June 15, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29912235/-peripartum-cardiomyopathy-a-little-known-disease
#7
Angela Beatrice Scardovi, Renata De Maria
Peripartum cardiomyopathy (PPCM) is a relatively rare cardiac disease that manifests itself in the final stage of pregnancy and in the first months after delivery in women with no previous history of cardiovascular disease. The incidence of PPCM varies widely across geographic areas and seems to be on the rise as a result of increased awareness and socioeconomic changes. PPCM recognizes a still partially undefined multifactorial etiology. Various pathogenetic hypotheses have been proposed, that range from autoimmune mechanisms to myocarditis to the hormonal hypothesis for aberrant, antiangiogenic and cardiotoxic prolactin (PRL) production, apoptosis, prolonged exposure to tocolytic drugs, malnutrition and genetic predisposition...
April 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29911625/local-up-regulation-of-interferon-%C3%AE-ifn-%C3%AE-following-disc-herniation-is-involved-in-the-inflammatory-response-underlying-acute-lumbar-radicular-pain
#8
G H Moen, A Moen, J Gjerstad
Aims Lumbar radicular pain after disc herniation may be associated release of pro-inflammatory cytokines from nucleus pulposus (NP) tissue. In the present study we examined the role of interferon-γ (IFN-γ) and cluster of differentiation 68 (CD68) in the acute phase of this process. Methods First, in an animal model mimicking the clinical situation after disc herniation, the role of IFN-γ on the dorsal horn single cell activity and gene expression close to the nerve roots was studied. Second, in patients with severe lumbar radicular pain due to disc herniation, we examined how two single nucleotide polymorphisms (SNPs; rs2069705 and rs2069718) important for the IFN-γ expression influenced the pain and disability measured by visual analogue scale (VAS) and Oswestry Disability Index (ODI)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911599/sinomenine-alleviates-mechanical-hypersensitivity-in-mice-with-experimentally-induced-rheumatoid-arthritis
#9
Tianle Gao, Tiansheng Shi, Zsuzsanna Wiesenfeld-Hallin, Camilla I Svensson, Xiao-Jun Xu
Background and aims We have previously reported that sinomenine, an alkaloid isolated from the root of the plant Sinomenium acutum, had antinociceptive effect in rodent models of acute inflammatory or neuropathic pain. As a traditional medicine, sinomenine is used in China to treat rheumatoid arthritis (RA). Methods In the present study, we evaluated the potential antinociceptive effect of sinomenine in a mouse model of RA, collagen type II antibody (CII Ab) induced arthritis (CAIA) after acute and chronic administration...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911573/managing-post-thoracotomy-pain-epidural-or-systemic-analgesia-and-extended-care-a-randomized-study-with-an-as-usual-control-group
#10
Elina Tiippana, Kaisa Nelskylä, Eija Nilsson, Eero Sihvo, Matti Kataja, Eija Kalso
Background and aims Thoracotomies can cause severe pain, which persists in 21-67% of patients. We investigated whether NSAID + intravenous patient-controlled analgesia (IV-PCA) with morphine is an efficacious alternative to thoracic epidural analgesia (TEA). We also wanted to find out whether an extended controlled pain management protocol within a clinical study can decrease the incidence of persistent post-thoracotomy pain. Methods Thirty thoracotomy patients were randomized into 3 intervention groups with 10 patients in each...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911083/displaced-midshaft-clavicle-fracture-in-athletes-should-we-operate
#11
Neydson André Solposto Marques de Souza, Paulo Santoro Belangero, Eduardo Antônio de Figueiredo, Alberto de Casto Pochini, Carlos Vicente Andreoli, Benno Ejnisman
Objective: To assess the results of the treatment of fractures of the middle third of the clavicle with a pre-contoured plate in athletes. Methods: The authors performed 26 osteosyntheseis in 25 patients with fractures of the middle third of the clavicle. The fractures were classified according to Robinson as 16 type B1 and ten type B2. The mean age was 37 years, ranging from 15 to 63 years, 20 patients were male and five were female, and all play sports in an amateur or professional manner...
March 2018: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29910832/phase-i-ii-study-on-kilovoltage-surface-brachytherapy-in-conjunctival-cancer-preliminary-results
#12
Gustavo R Sarria, Gustavo J Sarria, Paola Fuentes Rivera, Mayer Zaharia, Solón Serpa, Mario Buitrago
Introduction: In ocular conjunctival carcinoma after surgery, adjuvant treatment has a role and kilovoltage surface brachytherapy opens a new door for the range of therapeutic options. Materials and methods: Between October 2014 and June 2017, at the National Institute of Neoplastic Diseases (INEN) from Peru, 39 patients with squamous cell carcinoma of ocular conjunctiva, T1-T3, resected, were selected to receive adjuvant treatment. The portable accelerator of 50-kV INTRABEAM (Carl Zeiss Meditec) was used, after local anaesthesia and blocking of ocular muscles movement...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29910793/extracellular-vesicles-in-chagas-disease-a-new-passenger-for-an-old-disease
#13
REVIEW
Luis M de Pablos Torró, Lissette Retana Moreira, Antonio Osuna
Extracellular vesicles (EVs) are small lipid vesicles released by prokaryotic and eukaryotic cells containing nucleic acids, proteins, and small metabolites essential for cellular communication. Depending on the targeted cell, EVs can act either locally or in distant tissues in a paracrine or endocrine cell signaling manner. Released EVs from virus-infected cells, bacteria, fungi, or parasites have been demonstrated to perform a pivotal role in a myriad of biochemical changes occurring in the host and pathogen, including the modulation the immune system...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29910710/supplemental-stimulation-improves-swing-phase-kinematics-during-exoskeleton-assisted-gait-of-sci-subjects-with-severe-muscle-spasticity
#14
Andrew Ekelem, Michael Goldfarb
Spasticity is a common comorbidity associated with spinal cord injury (SCI). Robotic exoskeletons have recently emerged to facilitate legged mobility in people with motor complete SCI. Involuntary muscle activity attributed to spasticity, however, can prevent such individuals from using an exoskeleton. Specifically, although most exoskeleton technologies can accommodate low to moderate spasticity, the presence of moderate to severe spasticity can significantly impair gait kinematics when using an exoskeleton...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29910582/management-of-hyperglycemia-during-and-in-the-immediate-follow-up-of-acute-coronary-syndrome
#15
REVIEW
Jamal El Ouazzani, Amine Ghalem, Ghizlane El Ouazzani, Nabila Ismaili, Noha El Ouafi
Diabetes is a serious, frequent, and insidious morbidity and mortality risk factor in patients with coronary artery disease. It has been shown that carbohydrate metabolism disorders are common in acute coronary syndromes (ACSs): 30-40% of patients have diabetes, 25-36% have an intolerance to carbohydrates, and only 30-40% have a normal carbohydrate profile. Hyperglycemia occurring either in diabetic or nondiabetic patients is strongly associated with a poor prognosis. It increases the extent of myocardial necrosis, and the risk of recurrence acute coronary syndrome and hemodynamic complications, particularly heart failure and cardiogenic shock, reflecting the importance of optimal management of glucose metabolism abnormalities...
April 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29910042/belimumab-in-kidney-transplantation-an-experimental-medicine-randomised-placebo-controlled-phase-2-trial
#16
Gemma D Banham, Shaun M Flint, Nicholas Torpey, Paul A Lyons, Don N Shanahan, Adele Gibson, Christopher J E Watson, Ann-Marie O'Sullivan, Joseph A Chadwick, Katie E Foster, Rachel B Jones, Luke R Devey, Anna Richards, Lars-Peter Erwig, Caroline O Savage, Kenneth G C Smith, Robert B Henderson, Menna R Clatworthy
BACKGROUND: B cells produce alloantibodies and activate alloreactive T cells, negatively affecting kidney transplant survival. By contrast, regulatory B cells are associated with transplant tolerance. Immunotherapies are needed that inhibit B-cell effector function, including antibody secretion, while sparing regulators and minimising infection risk. B lymphocyte stimulator (BLyS) is a cytokine that promotes B-cell activation and has not previously been targeted in kidney transplant recipients...
June 14, 2018: Lancet
https://www.readbyqxmd.com/read/29910040/sodium-bicarbonate-therapy-for-patients-with-severe-metabolic-acidaemia-in-the-intensive-care-unit-bicar-icu-a-multicentre-open-label-randomised-controlled-phase-3-trial
#17
Samir Jaber, Catherine Paugam, Emmanuel Futier, Jean-Yves Lefrant, Sigismond Lasocki, Thomas Lescot, Julien Pottecher, Alexandre Demoule, Martine Ferrandière, Karim Asehnoune, Jean Dellamonica, Lionel Velly, Paër-Sélim Abback, Audrey de Jong, Vincent Brunot, Fouad Belafia, Antoine Roquilly, Gérald Chanques, Laurent Muller, Jean-Michel Constantin, Helena Bertet, Kada Klouche, Nicolas Molinari, Boris Jung
BACKGROUND: Acute acidaemia is frequently observed during critical illness. Sodium bicarbonate infusion for the treatment of severe metabolic acidaemia is a possible treatment option but remains controversial, as no studies to date have examined its effect on clinical outcomes. Therefore, we aimed to evaluate whether sodium bicarbonate infusion would improve these outcomes in critically ill patients. METHODS: We did a multicentre, open-label, randomised controlled, phase 3 trial...
June 14, 2018: Lancet
https://www.readbyqxmd.com/read/29909763/-pharmacotherapy-of-schizophrenia-spectrum-disorders-state-of-the-art
#18
Philipp E Eich, Beat Nick
Pharmacotherapy of schizophrenia spectrum disorders: State of the Art Abstract. Schizophrenia is a disorder, whose cause and course are still a puzzle. Nevertheless its treatment has made big progresses during the last decades. Early recognition and early treatment of the disorder are very important for a good outcome. Any of the four stages of the illness needs its own treatment concept. Today the gold standard during a acute / progressive psychotic phase is primarily the prescription of an 2nd generation antipsychotic (atypicals)...
June 2018: Therapeutische Umschau. Revue Thérapeutique
https://www.readbyqxmd.com/read/29909433/pharmacokinetics-of-fentanyl-sublingual-spray-in-opioid-na%C3%A3-ve-participants-results-of-a-phase-1-multiple-ascending-dose-study
#19
Richard L Rauck, D Alexander Oh, Neil Singla, Christian Koch, Neha Parikh, Srinivas Nalamachu, Jin Yu, Steven James
BACKGROUND AND OBJECTIVES: Fentanyl sublingual spray may be a viable alternative to intravenous (IV) opioids for the treatment of acute pain. As patients with acute pain may include those who have limited prior exposure to opioids, this phase 1, open-label, randomized, multiple ascending-dose study was conducted to assess the pharmacokinetics, pharmacodynamics, safety, and tolerability of multiple doses of fentanyl sublingual spray in opioid-naïve participants. This article primarily reports the pharmacokinetics results...
June 16, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29909129/transmissible-gastroenteritis-virus-n-protein-causes-endoplasmic-reticulum-stress-up-regulates-interleukin-8-expression-and-its-subcellular-localization-in-the-porcine-intestinal-epithelial-cell
#20
Qi Zhang, Ying Xu, Rong Chang, Dewen Tong, Xingang Xu
This essay focuses on transmissible gastroenteritis virus (TGEV), which is an enteropathogenic virus related to contagious and acute diseases in suckling piglets. Previous literature suggests that the TGEV nucleocapsid protein (N) plays a significant role in viral transcriptional process, however, there is a need to examine other functions of TGEV N protein in the porcine intestinal epithelial cell (IEC) which is the target cell of TGEV. In the present study, we investigated the degradation, subcellular localisation, and function of TGEV N protein by examining its effects on cycle progression, endoplasmic reticulum (ER) stress, interleukin-8 (IL-8) expression, and cell survival...
June 12, 2018: Research in Veterinary Science
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