Aditya Raghunathan, Khalida Wani, Terri S Armstrong, Elizabeth Vera-Bolanos, Maryam Fouladi, Richard Gilbertson, Amar Gajjar, Stewart Goldman, Norman L Lehman, Phillipe Metellus, Tom Mikkelsen, Mary Jo T Necesito-Reyes, Antonio Omuro, Roger J Packer, Sonia Partap, Ian F Pollack, Michael D Prados, H Ian Robins, Riccardo Soffietti, Jing Wu, C Ryan Miller, Mark R Gilbert, Kenneth D Aldape
Ependymomas originate in posterior fossa (PF), supratentorial (ST) or spinal cord (SC) compartments. At present, grading schemes are applied independent of anatomic site. We performed detailed histological examination on 238 World Health Organization grade II and III ependymomas. Among PF ependymomas, the presence of hypercellular areas, necrosis, microvascular proliferation and elevated mitotic rate (all P < 0.01) were significantly associated with worse progression-free survival (PFS), while extensive ependymal canal formation was not (P = 0...
September 2013: Brain Pathology