Pengxu Kong, Xiang Liu, Zefu Li, Jingrong Wang, Rui Gao, Shuyi Feng, Hang Li, Fengwen Zhang, Zujian Feng, Pingsheng Huang, Shouzheng Wang, Donglin Zhuang, Wenbin Ouyang, Weiwei Wang, Xiangbin Pan
Transcatheter intervention has been the preferred treatment for congenital structural heart diseases by implanting occluders into the heart defect site through minimally invasive access. Biodegradable polymers provide a promising alternative for cardiovascular implants by conferring therapeutic function and eliminating long-term complications, but inducing in situ cardiac tissue regeneration remains a substantial clinical challenge. PGAG (polydioxanone/poly (l-lactic acid)-gelatin-A5G81) occluders are prepared by covalently conjugating biomolecules composed of gelatin and layer adhesive protein-derived peptides (A5G81) to the surface of polydioxanone and poly (l-lactic acid) fibers...
November 20, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)