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https://www.readbyqxmd.com/read/28766287/single-molecule-analysis-of-pre-mrna-splicing-with-colocalization-single-molecule-spectroscopy-cosmos
#1
Joerg E Braun, Victor Serebrov
Recent development of single-molecule techniques to study pre-mRNA splicing has provided insights into the dynamic nature of the spliceosome. Colocalization single-molecule spectroscopy (CoSMoS) allows following spliceosome assembly in real time at single-molecule resolution in the full complexity of cellular extracts. A detailed protocol of CoSMoS has been published previously (Anderson and Hoskins, Methods Mol Biol 1126:217-241, 2014). Here, we provide an update on the technical advances since the first CoSMoS studies including slide surface treatment, data processing, and representation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28684380/quantum-gravity-and-taoist-cosmology-exploring-the-ancient-origins-of-phenomenological-string-theory
#2
REVIEW
Steven M Rosen
This paper carries forward the author's contribution to PBMP's previous special issue on Integral Biomathics (Rosen 2015). In the earlier paper, the crisis in contemporary theoretical physics was described and it was demonstrated that the problem can be addressed effectively only by shifting the foundations of physics from objectivist Cartesian philosophy to phenomenological philosophy. To that end, a phenomenological string theory was proposed based on qualitative topology and hypercomplex numbers. The current presentation takes this further by delving into the ancient Chinese origin of phenomenological string theory...
July 4, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28655863/evolution-of-biosynthetic-diversity
#3
REVIEW
Anthony J Michael
Since the emergence of the last common ancestor from which all extant life evolved, the metabolite repertoire of cells has increased and diversified. Not only has the metabolite cosmos expanded, but the ways in which the same metabolites are made have diversified. Enzymes catalyzing the same reaction have evolved independently from different protein folds; the same protein fold can produce enzymes recognizing different substrates, and enzymes performing different chemistries. Genes encoding useful enzymes can be transferred between organisms and even between the major domains of life...
June 27, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28648288/characterization-of-bacillus-megaterium-bacillus-pumilus-and-paenibacillus-polymyxa-isolated-from-a-pinot-noir-wine-from-western-washington-state
#4
Nicolas H von Cosmos, Bruce A Watson, J K Fellman, D S Mattinson, Charles G Edwards
This report provides the first confirmed evidence of Bacillus-like bacteria present in a wine from Washington State. These bacteria were isolated from a 2013 Pinot noir wine whose aroma was sensorially described as being 'dirty' or 'pond scum.' Based on physiological traits and genetic sequencing, three bacterial isolates were identified as Bacillus megaterium (strain NHO-1), Bacillus pumilus (strain NHO-2), and Paenibacillus polymyxa (strain NHO-3). These bacteria grew in synthetic media of low pH (pH 3.5) while some survived ethanol concentrations up to 15% v/v...
October 2017: Food Microbiology
https://www.readbyqxmd.com/read/28592654/water-is-an-active-matrix-of-life-for-cell-and-molecular-biology
#5
Philip Ball
Szent-Győrgi called water the "matrix of life" and claimed that there was no life without it. This statement is true, as far as we know, on our planet, but it is not clear whether it must hold throughout the cosmos. To evaluate that question requires a close consideration of the many varied and subtle roles that water plays in living cells-a consideration that must be free of both an assumed essentialism that gives water an almost mystical life-giving agency and a traditional tendency to see it as a merely passive solvent...
June 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28556634/uniportal-vats-for-treatment-of-bullous-lung-disease
#6
Hussein Elkhayat, Mahmoud Sallam, Mohamed Farouk, Khaled Hussein, Emad Zarief
This tutorial shows the resection of a bulla by uniportal video assisted thoracoscopic surgery in bullous lung disease. This disease is a benign condition requiring treatment in cases of severe dyspnea, spontaneous secondary pneumothorax, repeated infection, hemoptysis, and an increase in bulla size. The uniportal VATS approach results in less pain, better cosmoses, and a quicker recovery for the patient.
April 26, 2017: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/28556244/coherence-enhancement-in-quantitative-susceptibility-mapping-by-means-of-anisotropic-weighting-in-morphology-enabled-dipole-inversion
#7
Youngwook Kee, Junghun Cho, Kofi Deh, Zhe Liu, Pascal Spincemaille, Yi Wang
PURPOSE: To investigate an anisotropic structural prior in morphology enabled dipole inversion (MEDI) for improving accuracy in quantitative susceptibility mapping (QSM). THEORY AND METHODS: Anisotropic weighting (AW) was devised and implemented to incorporate orientation information into the edge agreement in the MEDI method. AW performance was compared with isotropic weighting by testing and validating on in vivo brain multiple orientation MRI data using COSMOS and the (33) component of the susceptibility tensor as reference...
May 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28479067/enhanced-metabolite-annotation-via-dynamic-retention-time-prediction-steroidogenesis-alterations-as-a-case-study
#8
Giuseppe Marco Randazzo, David Tonoli, Petra Strajhar, Ioannis Xenarios, Alex Odermatt, Julien Boccard, Serge Rudaz
The development of metabolomics based on ultra-high pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) now allows hundreds to thousands of metabolites to be simultaneously monitored in biological matrices. In that context, bioinformatics and multivariate data analysis (MVA) play a crucial role in the detection of relevant alteration patterns. However, sound biological interpretations must necessarily be supported by metabolite identifications to be definitive or at least have a high degree of confidence...
April 23, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28477251/integrated-management-of-ash-from-industrial-and-domestic-combustion-a-new-sustainable-approach-for-reducing-greenhouse-gas-emissions-from-energy-conversion
#9
Laura Benassi, Rogerta Dalipi, Veronica Consigli, Michela Pasquali, Laura Borgese, Laura E Depero, Francis Clegg, Paul A Bingham, Elza Bontempi
This work supports, for the first time, the integrated management of waste materials arising from industrial processes (fly ash from municipal solid waste incineration and coal fly ash), agriculture (rice husk ash), and domestic activities (ash from wood biomass burning in domestic stoves). The main novelty of the paper is the reuse of wood pellet ash, an underestimated environmental problem, by the application of a new technology (COSMOS-RICE) that already involves the reuse of fly ashes from industrial and agricultural origins...
June 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28416255/differences-between-2nd-and-3rd-generation-seric-parathormone-determination-methods-on-mortality-in-haemodialysis-patients
#10
Laura Rodríguez-Osorio, Concepción de la Piedra, Mercedes Rubert, Marta Martín-Fernández, María Luisa González Casaus, Carolina Gracia-Iguacel, Jesús Egido, Ricardo Villa-Bellosta, Emilio González Parra
Parathormone plays a key role in controlling mineral metabolism. PTH is considered a uremic toxin causing cardiovascular damage and cardiovascular mortality in dialysis patients. There are two different assays to measure PTH called 2nd generation or intact PTH (iPTH) and 3rd generation or bioPTH (PTHbio). OBJECTIVE: To evaluate the differences in mortality of dialysis patients between both assays to measure PTH, as well as the possible prognostic role of the PTHbio/iPTH ratio. METHODS: 145 haemodialysis patients were included with 2-year monitoring including baseline laboratory test and annually thereafter...
July 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28409943/probing-the-scale-invariance-of-the-inflationary-power-spectrum-in-expanding-quasi-two-dimensional-dipolar-condensates
#11
Seok-Yeong Chä, Uwe R Fischer
We consider an analogue de Sitter cosmos in an expanding quasi-two-dimensional Bose-Einstein condensate with dominant dipole-dipole interactions between the atoms or molecules in the ultracold gas. It is demonstrated that a hallmark signature of inflationary cosmology, the scale invariance of the power spectrum of inflaton field correlations, experiences strong modifications when, at the initial stage of expansion, the excitation spectrum displays a roton minimum. Dipolar quantum gases thus furnish a viable laboratory tool to experimentally investigate, with well-defined and controllable initial conditions, whether primordial oscillation spectra deviating from Lorentz invariance at trans-Planckian momenta violate standard predictions of inflationary cosmology...
March 31, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28300487/parental-spirituality-in-life-threatening-pediatric-cancer
#12
David B Nicholas, Maru Barrera, Leeat Granek, Norma Mammone D'Agostino, Jenny Shaheed, Laura Beaune, Eric Bouffet, Beverley Antle
This study addressed parental spirituality in the context of pediatric cancer with a poor prognosis. Drawing upon previous research implementing a longitudinal grounded theory design examining parental hope, 35 parents were interviewed regarding their experiences with an emergent description of the role of spirituality in parents' daily lives. Spirituality included religious beliefs and practices, notions of a higher force or cosmos, relationship with a divine being, as well as elements emerging from meaning-making and relationships...
May 2017: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/28251685/primal-dual-and-forward-gradient-implementation-for-quantitative-susceptibility-mapping
#13
Youngwook Kee, Kofi Deh, Alexey Dimov, Pascal Spincemaille, Yi Wang
PURPOSE: To investigate the computational aspects of the prior term in quantitative susceptibility mapping (QSM) by (i) comparing the Gauss-Newton conjugate gradient (GNCG) algorithm that uses numerical conditioning (ie, modifies the prior term) with a primal-dual (PD) formulation that avoids this, and (ii) carrying out a comparison between a central and forward difference scheme for the discretization of the prior term. THEORY AND METHODS: A spatially continuous formulation of the regularized QSM inversion problem and its PD formulation were derived...
March 1, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28228098/anti-obesity-effect-of-ethanolic-extract-from-cosmos-caudatus-kunth-leaf-in-lean-rats-fed-a-high-fat-diet
#14
Hafeedza Abdul Rahman, Najla Gooda Sahib, Nazamid Saari, Faridah Abas, Amin Ismail, Muhammad Waseem Mumtaz, Azizah Abdul Hamid
BACKGROUND: Obesity is a major health concern both in developed and developing countries. The use of herbal medicines became the subject of interest for the management of obesity due to its natural origin, cost effectiveness and minimal side effects. The present study aimed at investigating anti-obesity potential of ethanolic extract from Cosmos caudatus Kunth leaf (EECCL). METHODS: In this study, the rats were randomly divided into six groups i.e., (1) Normal Diet (ND); (2) Normal Diet and 175 mg/kgBW of EECCL (ND + 175 mg/kgBW); (3) Normal Diet and 350 mg/kgBW of EECCL (ND + 350 mg/kgBW); (4) High Fat Diet (HFD); (5) High Fat Diet and 175 mg/kgBW of EECCL (HFD + 175 mg/kgBW); (6) High Fat Diet and 350 mg/kgBW of EECCL (HFD + 350 mg/kgBW)...
February 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28179674/physics-a-cosmos-in-the-lab
#15
Andreas Albrecht
No abstract text is available yet for this article.
February 8, 2017: Nature
https://www.readbyqxmd.com/read/28179230/exposure-to-low-dose-computed-tomography-for-lung-cancer-screening-and-risk-of-cancer-secondary-analysis-of-trial-data-and-risk-benefit-analysis
#16
Cristiano Rampinelli, Paolo De Marco, Daniela Origgi, Patrick Maisonneuve, Monica Casiraghi, Giulia Veronesi, Lorenzo Spaggiari, Massimo Bellomi
Objective To estimate the cumulative radiation exposure and lifetime attributable risk of cancer incidence associated with lung cancer screening using annual low dose computed tomography (CT).Design Secondary analysis of data from a lung cancer screening trial and risk-benefit analysis.Setting 10 year, non-randomised, single centre, low dose CT, lung cancer screening trial (COSMOS study) which took place in Milan, Italy in 2004-15 (enrolment in 2004-05). Secondary analysis took place in 2015-16.Participants High risk asymptomatic smokers aged 50 and older, who were current or former smokers (≥20 pack years), and had no history of cancer in the previous five years...
February 8, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28113841/quantitative-susceptibility-mapping-using-structural-feature-based-collaborative-reconstruction-sfcr-in-the-human-brain
#17
Lijun Bao, Xu Li, Congbo Cai, Zhong Chen, Peter van Zijl
The reconstruction of MR quantitative susceptibility mapping (QSM) from local phase measurements is an ill posed inverse problem and different regularization strategies incorporating a priori information extracted from magnitude and phase images have been proposed. However, the anatomy observed in magnitude and phase images does not always coincide spatially with that in susceptibility maps, which could give erroneous estimation in the reconstructed susceptibility map. In this paper, we develop a structural feature based collaborative reconstruction (SFCR) method for QSM including both magnitude and susceptibility based information...
March 22, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28087210/evaluation-of-lip-force-in-patients-with-unilateral-and-bilateral-cleft-lip
#18
Y Fındık, T Baykul, M A Aydın, E Esenlik, B N Ordu
Our aim was to investigate the differences in the dynamics of lip force between a group of participants with repaired cleft lips and a group of patients the same age but without clefts. We evaluated 101 children between the ages of 10 to 15 years (unilateral clefts n=35, bilateral clefts n=15, class I malocclusion n=25, and class III malocclusion n=26). Maximum and minimum forces required to close the lips were evaluated with the Lip De Cum(®) device (Cosmos Instruments Co Ltd, Tokyo, Japan) for the all groups...
May 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28008020/the-cosmos-aquiver
#19
Adrian Cho
No abstract text is available yet for this article.
December 23, 2016: Science
https://www.readbyqxmd.com/read/27913842/alfonso-luis-herrera-and-the-beginnings-of-evolutionism-and-studies-in-the-origin-of-life-in-mexico
#20
Ismael Ledesma-Mateos, H James Cleaves
Alfonso Luis Herrera (1868-1942) was a Mexican biologist, and significant as the principal promoter of Darwinian thought in that country. However, Herrera's thinking went beyond the evolution of living beings, and extended to the question of the origin of life itself and the place of living phenomena in the larger context of the cosmos. Perhaps more significantly, though now largely forgotten, Herrera was among the first to embark on an experimental program to understand the origin of life, one which may be seen as foundational for later workers, most notably Sidney Fox and Alexander Oparin, and which has been resuscitated recently...
December 2016: Journal of Molecular Evolution
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