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https://www.readbyqxmd.com/read/28350555/apheresis-in-food-allergies
#1
Lamia Dahdah, Giovanna Leone, Mariacristina Artesani, Carla Riccardi, Oscar Mazzina
PURPOSE OF REVIEW: The prevalence of IgE-mediated food allergy and anaphylaxis has risen rapidly in developed countries, and countries with rapid industrialization may follow. Therapies include elimination diets, Oral ImmunoTherapy, and the administration of biologics, but high serum IgE levels may preclude their use. Consequently, decreasing IgE becomes a rational approach and could be obtained by immunoapheresis. The aim of this review is to evaluate the rationale and advantages of immunoapheresis...
March 27, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28346719/reduced-th22-cell-proportion-and-prevention-of-atopic-dermatitis-in-infants-following-maternal-probiotic-supplementation
#2
Anne Dorthea Bjerkenes Rø, Melanie Rae Simpson, Torstein Baade Rø, Ola Storrø, Roar Johnsen, Vibeke Videm, Torbjørn Øien
In the randomized, controlled study Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT), maternal probiotic supplementation reduced the incidence of atopic dermatitis (AD) in the offspring. In the current study, we hypothesized that the effect was mediated by a shift in the T helper (Th) cells in the children. OBJECTIVE: To examine whether Th cell proportions were affected by maternal probiotic supplementation and thus could mediate the preventive effect of probiotics on AD...
March 27, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28342195/a-simple-self-diagnosis-tool-to-assess-the-prevalence-of-dermatoporosis-in-france
#3
Jean-Hilaire Saurat, Valérie Mengeaud, Victor Georgescu, Christine Coutanceau, Khaled Ezzedine, Charles Taïeb
IMPORTANCE: The term dermatoporosis has been proposed to describe clinical signs and functional consequences of age-related extreme skin fragility. OBJECTIVE: To create a simple dermatoporosis self-diagnosis tool (IDA: Index Dermatoporosis Assessment) and to use this tool to estimate the prevalence of dermatoporosis in France. DESIGN, SETTING, AND PARTICIPANTS: A specific dermatoporosis questionnaire was developed with the help of senior dermatologists and survey experts...
March 25, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28341821/salicylate-food-intolerance-and-aspirin-hypersensitivity-in-nasal-polyposis
#4
Hossein Esmaeilzedeh, Elmira Esmaeilzadeh, Mohammad Faramarzi, Mohammad Nabavi, Mohammad Farhadi
BACKGROUND: A clear association between allergy and nasal polyposis (NP) is not determined and the role of food intolerance in patients with NP is not investigated by oral food challenge (OFC). OBJECTIVE: To investigate the relation of salicylate food intolerance and atopy in patients with NP according to recurrence and aspirin sensitivity. METHODS: A cross sectional multicenter study was done in two tertiary centers for allergy in Iran. Adult patients with NP were selected for the study that had been referred to allergy clinics...
March 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28340859/heterogeneity-of-obesity-asthma-association-disentangled-by-latent-class-analysis-the-sapaldia-cohort
#5
Ayoung Jeong, Medea Imboden, Sofie Hansen, Elisabeth Zemp, Pierre-Olivier Bridevaux, Gianfranco Lovison, Christian Schindler, Nicole Probst-Hensch
Although evidence for the heterogeneity of asthma accumulated, consensus for definitions of asthma phenotypes is still lacking. Obesity may have heterogeneous effects on various asthma phenotypes. We aimed to distinguish asthma phenotypes by latent class analysis and to investigate their associations with different obesity parameters in adults using a population-based Swiss cohort (SAPALDIA). We applied latent class analysis to 959 self-reported asthmatics using information on disease activity, atopy, and age of onset...
April 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28339128/life-course-of-atopy-and-allergy-related-disease-events-in-tropical-sub-saharan-africa-a-birth-cohort-study
#6
Swaib A Lule, Harriet Mpairwe, Margaret Nampijja, Florence Akello, Joyce Kabagenyi, Benigna Namara, Gyaviira Nkurunungi, Dennison Kizito, Joseph Kahwa, Lawrence Muhangi, Stephen Nash, Moses Muwanga, Emily L Webb, Alison M Elliott
BACKGROUND: In high-income countries, allergy related-diseases (ARDs) follow a typical sequence, the "Atopic March". Little is known about the life-course of ARDs in the markedly different, low-income, tropical environment. We describe ARDs in a tropical, African birth cohort. METHODS: Ugandan children were followed from birth to nine years. ISAAC questionnaires were completed at intervals; doctor-diagnosed ARDs were recorded throughout follow-up. Skin prick tests (SPTs) were done at three and nine years...
March 24, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28338223/efficacy-and-safety-of-ustekinumab-in-japanese-patients-with-severe-atopic-dermatitis-a-randomised-double-blind-placebo-controlled-phase-2-study
#7
H Saeki, K Kabashima, Y Tokura, Y Murata, A Shiraishi, R Tamamura, B Randazzo, K Imanaka
BACKGROUND: Ustekinumab, a fully human monoclonal antibody against interleukin-12/23, may be potentially effective for severe atopic dermatitis (AD) treatment. OBJECTIVES: To evaluate efficacy and safety of ustekinumab 45 mg and 90 mg in severe AD patients. METHODS: In this placebo-controlled, randomised, phase 2 study, adult Japanese patients (aged 20-65 years) with severe or very severe AD entered a 12-week double-blind treatment period to receive (1:1:1) ustekinumab 45 mg, 90 mg or placebo subcutaneous injections at weeks 0 and 4; follow-up until week 24...
March 24, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28334838/neutrophil-mediated-il-6-receptor-trans-signaling-and-the-risk-of-chronic-obstructive-pulmonary-disease-and-asthma
#8
Neda Farahi, Ellie Paige, Jozef Balla, Emily Prudence, Ricardo C Ferreira, Mark Southwood, Sarah L Appleby, Per Bakke, Amund Gulsvik, Augusto A Litonjua, David Sparrow, Edwin K Silverman, Michael H Cho, John Danesh, Dirk S Paul, Daniel F Freitag, Edwin R Chilvers
The Asp358Ala variant in the interleukin-6 receptor (IL-6R) gene has been implicated in asthma, autoimmune and cardiovascular disorders, but its role in other respiratory conditions such as chronic obstructive pulmonary disease (COPD) has not been investigated. The aims of this study were to evaluate whether there is an association between Asp358Ala and COPD or asthma risk, and to explore the role of the Asp358Ala variant in sIL-6R shedding from neutrophils and its pro-inflammatory effects in the lung. We undertook logistic regression using data from the UK Biobank and the ECLIPSE COPD cohort...
February 17, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28333952/adjuvant-treatment-with-the-bacterial-lysate-om-85-improves-management-of-atopic-dermatitis-a-randomized-study
#9
Christine Bodemer, Gerard Guillet, Frederic Cambazard, Franck Boralevi, Stefania Ballarini, Christian Milliet, Paola Bertuccio, Carlo La Vecchia, Jean-François Bach, Yves de Prost
BACKGROUND: Environmental factors play a major role on atopic dermatitis (AD) which shows a constant rise in prevalence in western countries over the last decades. The Hygiene Hypothesis suggesting an inverse relationship between incidence of infections and the increase in atopic diseases in these countries, is one of the working hypothesis proposed to explain this trend. OBJECTIVE: This study tested the efficacy and safety of oral administration of the bacterial lysate OM-85 (Broncho-Vaxom®, Broncho-Munal®, Ommunal®, Paxoral®, Vaxoral®), in the treatment of established AD in children...
2017: PloS One
https://www.readbyqxmd.com/read/28331140/management-of-atopic-dermatitis-in-japan
#10
Hidehisa Saeki
The guidelines for the treatment of atopic dermatitis (AD) issued by the Japanese Dermatological Association (JDA), which are basically designed for dermatologists, were first prepared in 2000 and revised in 2016. The guidelines for AD of the Japanese Society of Allergology (JSA), which are basically designed for allergologists, including internists, otorhinolaryngologists, ophthalmologists, and dermatologists, were first prepared in 2009 and revised in 2014. In this article, I review the definition, pathophysiology, etiology, epidemiology, diagnosis, severity classification, examination for diagnosis and severity assessment, and treatments for AD in Japan according to these two guidelines for AD (JDA and JSA)...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28330497/atopic-dermatitis-anti-ige-paediatric-trial-adapt-the-role-of-anti-ige-in-severe-paediatric-eczema-study-protocol-for-a-randomised-controlled-trial
#11
Susan Chan, Victoria Cornelius, Tao Chen, Suzana Radulovic, Mandy Wan, Rahi Jahan, Gideon Lack
BACKGROUND: The evidence for systemic treatments for severe childhood eczema is limited and largely based on extrapolation of data from adult studies. Current therapies are often immunosuppressant and may be associated with both short- and long-term side effects. There is increasing in vitro and murine-model evidence for the role of IgE in the immunopathogenesis of atopic eczema. The aim of the study is to assess whether anti-IgE treatment (omalizumab) improves eczema, compared to placebo...
March 22, 2017: Trials
https://www.readbyqxmd.com/read/28329641/differences-in-incidence-and-persistence-of-atopic-dermatitis-by-race-ethnicity
#12
M Blomberg, S L Rifas-Shiman, Ca Jr Camargo, D R Gold, J P Thyssen, A A Litonjua, M W Gillman, M M Asgari, E Oken
BackgroundMost studies on racial disparities in childhood atopic dermatitis (AD) did not consider persistent AD or account for differences in vitamin D status.MethodsAmong 1418 children recruited from a Massachusetts HMO into the pre-birth Project Viva cohort, we examined associations of child's race/ethnicity with maternal report of child's AD diagnosis by annual questionnaires. We used multivariable logistic regression adjusted for socio- demographics (maternal education, household income, smoking exposure, parental atopy, breastfeeding duration, child sex) and cord blood 25-hydroxyvitamin D, to estimate odds ratios (OR) of incident AD by early childhood (median age 3...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329627/association-of-atopic-dermatitis-with-tobacco-smoke-exposure-a-systematic-review-and-meta-analysis
#13
Robert Kantor, Ashley Kim, Jacob Thyssen, Jonathan I Silverberg
Previous studies found conflicting results about whether exposure to tobacco smoke is associated with increased atopic dermatitis (AD). We examined this association by systematic review and meta-analysis of MEDLINE, EMBASE, Scopus, and Cochrane Library and identified 86 studies, including 680,176 patients from 39 countries. A meta-analysis was performed using random-effects models to estimate pooled odds ratios (OR). Subset analyses were performed for different ages (children or adult), regions, study designs (cross-sectional vs...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28328088/evaluation-of-the-correlation-between-severity-of-acquired-idiopathic-generalized-anhidrosis-and-quality-of-life-scores
#14
Takichi Munetsugu, Tomoko Fujimoto, Takahiro Satoh, Yoshihiko Nakazato, Yuichiro Ohshima, Masato Asahina, Hiroo Yokozeki
Symptoms of acquired idiopathic generalized anhidrosis (AIGA) include heat retention and/or heat stroke due to the effects of the disorder on the perspiration ability of the whole body under thermal environmental changes or exercise. Additionally, cholinergic urticaria can also occur in these patients. AIGA has a major impact on everyday life. However, the effects of AIGA severity on the quality of life (QOL) of the patients have not been sufficiently defined. The objective of this study was to evaluate the correlation between AIGA severity and QOL...
March 22, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28326599/functional-dyspepsia-is-associated-with-duodenal-eosinophilia-in-an-australian-paediatric-cohort
#15
L Wauters, S Nightingale, N J Talley, B Sulaiman, M M Walker
BACKGROUND: The pathophysiology of functional dyspepsia (FD) remains unknown. Duodenal eosinophil infiltration has been reported. AIM: To assess the association between dyspeptic symptoms and duodenal eosinophilia in children undergoing upper gastrointestinal endoscopy. METHODS: In this retrospective cohort study, children with normal upper endoscopy and routine histology at a single tertiary paediatric centre between 2010 and 2014 were included...
March 21, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28323676/impact-of-elimination-diets-on-nutrition-and-growth-in-children-with-multiple-food-allergies
#16
Carina Venter, Alessandra Mazzocchi, Kate Maslin, Carlo Agostoni
PURPOSE OF REVIEW: Growth and nutritional intake of children with cows' milk allergy and other food allergens has been thoroughly investigated in recent years across many different countries and age groups. An impaired growth in atopic children should not be attributed only to a high number of allergens and foods to be avoided, but to a general condition of 'sub-inflammation', which unfavorably affects the absorption and utilization of fuel and substrates. Atopic study participants may represent a good target for personalized nutrition and in this review we sought to outline many of the issues that should be taken into account when dietitians advise patients regarding food avoidance and expected effects on growth...
March 18, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28322469/systemic-treatment-of-severe-adult-atopic-dermatitis-in-clinical-practice-analysis-of-prescribing-pattern-in-a-cohort-of-241-patients
#17
Salama Hegazy, Marie Tauber, Cristina Bulai Livideanu, Claire Uthuriague, Françoise Giordano Labadie, Marie Claude Marguery, Marie Masson Reignault, Maria Polina Konstantinou, Carle Paul
Adult Atopic dermatitis (AD) is a chronic, inflammatory skin disease which may severely impact quality of life. In patients with moderate to severe AD, major defects in skin barrier function and structure have been observed in both non lesional and lesional skin (1).Systemic treatment should be considered in patients who cannot be managed with topical therapies(2). The Guidelines do not give clear recommendations regarding which agents to use first based upon the benefits and risks of available systemic treatments(3)...
March 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28321782/targeting-interleukin-5-or-interleukin-5r%C3%AE-safety-considerations
#18
REVIEW
Diego Bagnasco, Matteo Ferrando, Marco Caminati, Alice Bragantini, Francesca Puggioni, Gilda Varricchi, Giovanni Passalacqua, Giorgio Walter Canonica
Asthma is a highly prevalent chronic disease of the airways; approximately 10% of patients with asthma will experience a severe form of the disease. New understanding of the pathogenesis of asthma has enabled the development of novel drugs and provided hope for patients with asthma. Interleukin (IL)-5 and IL-5 receptor subunit α (IL-5-Rα) plays a crucial role in the development, maturation, and operation of eosinophils so were the first important therapeutic target of these new drugs. While the results of early clinical trials of these drugs were not promising, results improved once researchers discovered the drugs worked best in patients with high eosinophil levels...
March 20, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28319560/rash-diagnostics-an-update-on-the-diagnosis-of-allergic-rashes
#19
Corinne Savides Happel
PURPOSE OF REVIEW: The purpose of this review is to summarize recent research regarding the diagnosis of allergic rashes and to suggest future directions for the promotion of accurate diagnosis and endotype specification. RECENT FINDINGS: Multiple cohort studies demonstrate that with appropriate clinical evaluation, drug allergy labels can be removed in up to 90% of cases. Genetic tests can predict severe adverse cutaneous drug reactions in some cases and in vitro tests are being sought to identify causative drugs in others...
March 17, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28318885/genetic-association-of-the-functional-cdhr3-genotype-with-early-onset-adult-asthma-in-japanese-populations
#20
Jun Kanazawa, Hironori Masuko, Yohei Yatagai, Tohru Sakamoto, Hideyasu Yamada, Yoshiko Kaneko, Haruna Kitazawa, Hiroaki Iijima, Takashi Naito, Takefumi Saito, Emiko Noguchi, Satoshi Konno, Masaharu Nishimura, Tomomitsu Hirota, Mayumi Tamari, Nobuyuki Hizawa
BACKGROUND: Recent studies have demonstrated that a coding SNP (rs6967330, Cys529→Tyr) in cadherin-related family member 3 (CDHR3), which was previously associated with wheezing illness and hospitalizations in infancy, could support efficient human rhinovirus C (RV-C) entry and replication. Here, we sought to examine the genetic contribution of this variant to the development of adult asthma. METHODS: We performed a candidate gene case-control association study of 2 independent Japanese populations (a total of 3366 adults)...
March 16, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
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