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Canine mammary gland tumor

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https://www.readbyqxmd.com/read/27892865/co-occurrence-of-a-metastatic-mammary-liposarcoma-and-an-ovarian-sex-cord-stromal-tumor-in-a-dog
#1
M Polinas, G P Burrai, V Marras, R Ariu, M T Zedda, S Pau, E Antuofermo
Sarcoma arising in the mammary gland is a rare tumor in dogs, and primary liposarcoma with metastatic behavior has never been previously reported among canine mammary tumors. A 14-year old female poodle had a mammary mass diagnosed as pleomorphic liposarcoma. Two years following surgical removal, the tumor recurred in the mammary gland with lymph node metastases. In addition, a sex-cord stromal tumor was identified in the ovary. Immunohistochemistry was performed on both tumors that were positive for oestrogen and progesterone receptors...
October 13, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27867085/optically-active-stereoisomers-of-5-1-iodoethyl-4-4-isopropylphenyl-dihydrofuran-2-one-the-effect-of-the-configuration-of-stereocenters-on-apoptosis-induction-in-canine-cancer-cell-lines
#2
Aleksandra Pawlak, Witold Gładkowski, Marcelina Mazur, Marta Henklewska, Bożena Obmińska-Mrukowicz, Andrzej Rapak
Four stereoisomers of δ-iodo-γ-lactones with p-isopropylphenyl substituent at β-position: cis-(4R,5R,6S)-1, cis-(4S,5S,6R)-2, trans-(4R,5S,6R)-3, trans-(4S,5R,6S)-4 with proved antiproliferative activity were subjected to in vitro tests for a better understanding of their anticancer activity. The subject of our interest was a possible relationship between a configuration of chiral centers of the studied lactones and their anticancer potency against a panel of canine cell lines representing hematopoietic (CLBL-1, GL-1, CL-1, CLB70) and mammary gland cancers (P114, CMT-U27, CMT-U309)...
November 17, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27764139/prevalence-of-glomerulopathies-in-canine-mammary-carcinoma
#3
Leandro Z Crivellenti, Gyl E B Silva, Sofia Borin-Crivellenti, Rachel Cianciolo, Christopher A Adin, Márcio Dantas, Denner S Dos Anjos, Mirela Tinucci-Costa, Aureo E Santana
The incidence and prevalence of paraneoplastic glomerulopathy, especially associated with carcinoma, are a matter of debate and the causal link between cancer and glomerular diseases remains unclear. The aim of this study was to evaluate renal biopsies of selected bitches with spontaneous mammary gland carcinoma. We hypothesized that dogs with mammary carcinomas would show histologic evidence of glomerular pathology. A prospective study was performed in dogs with naturally occurring mammary carcinoma that were undergoing tumor resection and ovariohysterectomy...
2016: PloS One
https://www.readbyqxmd.com/read/27703351/treatment-of-natural-mammary-gland-tumors-in-canines-and-felines-using-gold-nanorods-assisted-plasmonic-photothermal-therapy-to-induce-tumor-apoptosis
#4
Moustafa R K Ali, Ibrahim M Ibrahim, Hala R Ali, Salah A Selim, Mostafa A El-Sayed
Plasmonic photothermal therapy (PPTT) is a cancer therapy in which gold nanorods are injected at the site of a tumor before near-infrared light is transiently applied to the tumor causing localized cell death. Previously, PPTT studies have been carried out on xenograft mice models. Herein, we report a study showing the feasibility of PPTT as applied to natural tumors in the mammary glands of dogs and cats, which more realistically represent their human equivalents at the molecular level. We optimized a regime of three low PPTT doses at 2-week intervals that ablated tumors mainly via apoptosis in 13 natural mammary gland tumors from seven animals...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27698788/why-man-s-best-friend-the-dog-could-also-benefit-from-an-anti-her-2-vaccine
#5
Judit Fazekas, Irene Fürdös, Josef Singer, Erika Jensen-Jarolim
Human epidermal growth factor receptor-2 (HER-2) is a well-established target for anticancer anticancerprecision medicine in humans. A HER-2 homologue with 92% amino acid identity has been described in canine mammary tumors, which whichis termed here as 'dog epidermal growth factor receptor-2 (DER-2)', with similar biological implications as those in human breast cancer. Both antigens can principally be immunologically targeted by anti-HER-2 antibodies, such as trastuzumab; however, the in vivo application applicationof humanized antibodies to other species would lead to specific hypersensitivity reactions...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27698175/canine-mammary-minute-oncocytomas-with-neuroendocrine-differentiation-associated-with-multifocal-acinar-cell-oncocytic-metaplasia
#6
Rei Nagahara, Masayuki Kimura, Megu Itahashi, Go Sugahara, Masashi Kawashima, Hirotada Murayama, Toshinori Yoshida, Makoto Shibutani
Two solitary and minute tumors of 1 and 1.5 mm diameter were identified by microscopy in the left fourth mammary gland of a 13-year-old female Labrador Retriever dog, in addition to multiple mammary gland tumors. The former tumors were well circumscribed and were composed of small-to-large polyhedral neoplastic oncocytes with finely granular eosinophilic cytoplasm, and were arranged in solid nests separated by fine fibrovascular septa. Scattered lumina of variable sizes containing eosinophilic secretory material were evident...
November 2016: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/27632571/fgf2-and-egf-are-required-for-self-renewal-and-organoid-formation-of-canine-normal-and-tumor-breast-stem-cells
#7
Cinzia Cocola, Stefano Molgora, Eleonora Piscitelli, Maria Cristina Veronesi, Marianna Greco, Cinzia Bragato, Monica Moro, Mariacristina Crosti, Brian Gray, Luciano Milanesi, Valeria Grieco, Gaia Cecilia Luvoni, James Kehler, Gianfranco Bellipanni, Rolland Reinbold, Ileana Zucchi, Antonio Giordano
Recent studies suggest that human tumors are generated from cancer cells with stem cell (SC) properties. Spontaneously occurring cancers in dogs contain a diversity of cells that like for human tumors suggest that certain canine tumors are also generated from cancer stem cells (CSCs). CSCs, like normal SCs, have the capacity for self-renewal as mammospheres in suspension cultures. To understand how cells with SC properties contribute to canine mammary gland tumor development and progression, comparative analysis between normal SCs and CSCs, obtained from the same individual, is essential...
September 15, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27586466/evaluation-of-expression-of-the-wnt-signaling-components-in-canine-mammary-tumors-by-rt%C3%A2-profiler-pcr-array-and-immunochemistry
#8
Fang Yu, Roberta Rasotto, Hong Zhang, Shimin Pei, Bin Zhou, Xu Yang, Yipeng Jin, Di Zhang, Degui Lin
The Wnt signaling pathway and its key component β-catenin play critical roles in the development of diseases such as tumors in mammals. However, little is known about involvement of the Wnt/β-catenin signaling pathway in canine mammary tumors (CMTs). The present study detected the expression of 30 Wnt signaling pathway-related genes in CMTs, which are potentially useful for molecular diagnosis of CMTs and the development of new targeted therapies. Significant upregulation of DKK1, SFRP1, FZD3, β-catenin and LEF1 was detected in highly malignant CMTs compared to those in normal mammary gland tissues; while extremely significant upregulation of WNT5A was found in low malignant CMTs...
September 1, 2016: Journal of Veterinary Science
https://www.readbyqxmd.com/read/27543935/evaluation-of-vascular-endothelial-growth-factor-gene-and-protein-expression-in-canine-metastatic-mammary-carcinomas
#9
Talita M M Raposo-Ferreira, Rosana C L Salvador, Erika M Terra, Juarez H Ferreira, Ivan José Vechetti-Junior, Mirela Tinucci-Costa, Silvia R Rogatto, Renée Laufer-Amorim
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor that could be associated with the induction of endothelial cell proliferation and metastasis. In this study, we evaluated VEGF gene and protein expression in canine mammary tumors (CMT), including metastatic carcinomas, to determine if there is an influence of this marker in the malignant processes and aggressiveness of CMT. We also compared VEGF protein levels with clinicopathological features. The VEGF gene and protein expression levels were evaluated by reverse transcription-quantitative polymerase chain reaction and immunohistochemistry, respectively, in normal mammary gland samples, benign mammary tumors, nonmetastatic mammary carcinomas, and metastatic mammary carcinomas...
August 20, 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27490467/her-2-and-egfr-mrna-expression-and-its-relationship-with-versican-in-malignant-matrix-producing-tumors-of-the-canine-mammary-gland
#10
Karine Araújo Damasceno, Enio Ferreira, Alessandra Estrela-Lima, Conrado de Oliveira Gamba, Fernanda Freitas Miranda, Mariana Rezende Alves, Rafael Malagoli Rocha, André Luís Branco de Barros, Geovanni Dantas Cassali
Versican expression promotes tumor growth by destabilizing focal cell contacts, thus impeding cell adhesion and facilitating cell migration. It not only presents or recruits molecules to the cell surface, but also modulates gene expression levels and coordinates complex signal pathways. Previously, we suggested that the interaction between versican and human epidermal growth factor receptors may be directly associated with tumor aggressiveness. Thus, the expression of EGFR and HER-2 in these neoplasms may contribute to a better understanding of the progression mechanisms in malignant mammary tumors...
2016: PloS One
https://www.readbyqxmd.com/read/27487499/the-relationship-between-basal-and-luminal-cytokeratins-with-histopathologic-characteristics-of-canine-mammary-gland-cancer
#11
D Eivani, P Mortazavi
Neoplasia occurs mostly in mammary glands in female dogs and mammary gland cancer is one of the causes of death in these animals cytokeratins are one of the most important of tumor markers for identification of tumor prognosis. In this study, 120 canine malignant tumor samples of mammary glands were studied. From each sample, a section was taken for hematoxylin-eosin staining and two sections for immunohistochemical staining of markers CK5/6 and CK7. Histopathology slides was evaluated by light microscope. The results show that the presence of markers CK7 and CK5/6 had no significant relationship with tumor grade and type (p<0...
2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27457231/expression-of-ccdc85c-a-causative-protein-for-murine-hydrocephalus-in-the-mammary-gland-tumors-of-dogs
#12
Natsuki Tanaka, Takeshi Izawa, Shigeo Takenaka, Hideo Akiyoshi, Jyoji Yamate, Mitsuru Kuwamura
Coiled-coil domain containing 85c (Ccdc85c) is a causative gene for hemorrhagic hydrocephalus mouse which shows hydrocephalus with frequent brain hemorrhage and formation of subcortical band heterotopia. A previous study revealed that Ccdc85C protein is expressed in the systemic simple epithelial cells with proliferative activity in rats and suggested that Ccdc85C expression may be related to the cell proliferation of simple epithelial cells. To reveal the roles of Ccdc85C in the proliferative lesion, we examined the expression patterns of Ccdc85C in the mammary gland tumor of dogs, a common representative tumor derived from simple epithelial cells...
July 26, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27307036/embryonic-stem-cell-gene-expression-signatures-in-the-canine-mammary-tumor-a-bioinformatics-approach
#13
Mohamad Zamani-Ahmadmahmudi
Canine breast cancer was considered as an ideal model of comparative oncology for the human breast cancer, as there is significant overlap between biological and clinical characteristics of the human and canine breast cancer. We attempt to clarify expression profile of the embryonic stem cell (ES) gene signatures in canine breast cancer. Using microarray datasets (GSE22516 and GSE20718), expression of the three major ES gene signatures (modules or gene-sets), including Myc, ESC-like, and PRC modules, was primarily analyzed through Gene-Set Enrichment Analysis (GSEA) method in tumor and healthy datasets...
August 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27162119/ki-67-and-pcna-expression-in-canine-mammary-tumors-and-adjacent-nonneoplastic-mammary-glands-prognostic-impact-by-a-multivariate-survival-analysis
#14
M I Carvalho, I Pires, J Prada, L Lobo, F L Queiroga
The assessment of tumor proliferation has been considered a determining prognostic factor in canine mammary tumors (CMTs). However, no studies have assessed the prognostic importance of proliferation in adjacent nonneoplastic mammary glands. We included 64 CMTs (21 benign and 43 malignant) and studied the proliferation index (PI) of Ki-67 and proliferating cell nuclear antigen (PCNA) together with several clinicopathological characteristics. A positive and statistically significant correlation between the PI of Ki-67 and PCNA in tumors and adjacent nonneoplastic mammary glands was observed in benign and malignant tumors...
May 9, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27150207/canine-tumor-development-and-crude-incidence-of-tumors-by-breed-based-on-domestic-dogs-in-gifu-prefecture
#15
Satoshi Komazawa, Hiroki Sakai, Yusuke Itoh, Mifumi Kawabe, Mami Murakami, Takashi Mori, Kohji Maruo
We analyzed the status of tumor development in dogs by breed based on tumor cases that presented to the Department of Veterinary Pathology of the Gifu University for diagnostic examinations over eight years (2005-2012). We also calculated the crude incidence of tumors in dogs by breed based on the results of a survey conducted in 2011 in Gifu Prefecture. The most common sites of tumor development included the skin, digestive organs and mammary glands. Smaller dogs showed a tendency to have a higher incidence of breast tumors...
September 1, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27107075/programmed-cell-death-ligand-1-expression-in-canine-cancer
#16
Kazuha Shosu, Masashi Sakurai, Kumi Inoue, Takayuki Nakagawa, Hiroki Sakai, Masahiro Morimoto, Masaru Okuda, Shunsuke Noguchi, Takuya Mizuno
BACKGROUND: Antibody therapy targeting programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) is a promising therapy in human cancer, but only limited information on PD-L1 expression in canine tumors is available. MATERIALS AND METHODS: PD-L1 expression was examined in 31 canine tumor cell lines of various origins by flow cytometry and western blotting, and in canine tumor and normal tissue specimens by immunohistochemistry. RESULTS: PD-L1 was only expressed on the cell surface of a small number of cell lines but was found expressed within the cells of almost all cell lines...
May 2016: In Vivo
https://www.readbyqxmd.com/read/27106737/downregulation-of-atm-gene-and-protein-expression-in-canine-mammary-tumors
#17
T M M Raposo-Ferreira, R C Bueno, E M Terra, M L Avante, M Tinucci-Costa, M Carvalho, G D Cassali, S D Linde, S R Rogatto, R Laufer-Amorim
The ataxia telangiectasia mutated (ATM) gene encodes a protein associated with DNA damage repair and maintenance of genomic integrity. In women, ATM transcript and protein downregulation have been reported in sporadic breast carcinomas, and the absence of ATM protein expression has been associated with poor prognosis. The aim of this study was to evaluate ATM gene and protein expression in canine mammary tumors and their association with clinical outcome. ATM gene and protein expression was evaluated by reverse transcription-quantitative polymerase chain reaction and immunohistochemistry, respectively, in normal mammary gland samples (n = 10), benign mammary tumors (n = 11), nonmetastatic mammary carcinomas (n = 19), and metastatic mammary carcinomas (n = 11)...
April 22, 2016: Veterinary Pathology
https://www.readbyqxmd.com/read/27027841/role-of-tissue-factor-expression-in-thrombin-generation-by-canine-tumor-cells
#18
Erika J Gruber, James L Catalfamo, Tracy Stokol
OBJECTIVE: To measure thrombin generation by high and low tissue factor (TF)-expressing canine cancer cell lines. SAMPLE: Canine cell lines CMT25 (high TF-expressing mammary gland tumor cell line) and HMPOS (low TF-expressing osteosarcoma cell line). PROCEDURES: Thrombin generation by cancer cells was measured in pooled normal canine plasma by use of calibrated automated thrombography without added trigger reagents. Results were expressed as lag time, time to peak thrombin concentration, peak thrombin concentration, and total thrombin concentration or thrombin generation potential...
April 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/26979595/expression-and-characterization-of-tissue-inhibitor-of-metalloproteinase-4-from-complex-canine-mammary-carcinomas
#19
Navneet Kaur, B V Sunil Kumar, Kanika Mahajan, Satparkash Singh
All four members of the tissue inhibitors of metalloproteinase (TIMP) family have been reported to be over-expressed in breast cancer cells in vitro. Dysregulation of TIMP-4 expression predicts poor prognosis in cancers. The present study evaluated the association of the expression levels of TIMP-4 with mammary tumor development in dogs, measured by real-time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Mammary tissue samples were collected from healthy canine mammary gland and from tumor subjects...
2016: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/26948297/incidence-of-mammary-tumors-in-the-canine-population-living-in-the-veneto-region-northeastern-italy-risk-factors-and-similarities-to-human-breast-cancer
#20
Marta Vascellari, Katia Capello, Antonio Carminato, Claudia Zanardello, Elisa Baioni, Franco Mutinelli
Although mammary gland tumors (MT) are the most-common type of tumor in intact female dogs, there is little information about their incidence in dog population. Data on MT in female dogs was retrieved from the Animal Tumor registry of dogs and cats of Venice and Vicenza provinces during 2005-2013 and was analyzed to visualize crude incidence rates by breed and across age categories. Overall, 2744 mammary tumors were reported accounting for 54% of all tumors in female dogs. The annual incidence rate (IR) was 250 cases per 100,000 dogs...
April 1, 2016: Preventive Veterinary Medicine
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