keyword
https://read.qxmd.com/read/38537125/efficacy-of-a-novel-antibiotic-drug-combination-toward-multidrug-resistant-ocular-pathogens
#1
JOURNAL ARTICLE
Lakshminarayanan Gowtham, Rachel A F Wozniak, Paul M Dunman, Esther Sheba, Prashant Garg, Joveeta Joseph
PURPOSE: Antimicrobial resistance is a global health threat, compounded by the reduction in the discovery of new antibiotics. A repurposed drugs-based approach could provide a viable alternative for the treatment of multidrug-resistant (MDR) bacterial infections. In this study, we sought to evaluate the in vitro efficacy of a novel drug combination, polymyxin B/trimethoprim (PT) + rifampin on MDR isolates from patients with bacterial keratitis in India. METHODS: Forty-three isolates, which included 20 Staphylococcus aureus, 19 Pseudomonas aeruginosa, 3 Pseudomonas stutzeri, and 1 Acinetobacter baumannii, were evaluated for their antibiotic resistance by minimum inhibitory concentration (MIC)...
March 26, 2024: Cornea
https://read.qxmd.com/read/38536967/uncovering-the-power-of-hsccc-separation-of-diastereomeric-and-regioisomeric-styrylpyrones-from-the-stem-bark-of-goniothalamus-leiocarpus
#2
JOURNAL ARTICLE
Xiao Liu, Ling-Yun Li, Zhi-Qin Zhang, Xiu-Chuan Fu, Rong-Sheng Li, Jia-Li Yao, Simon Gibbons, Qing Mu
The plant Goniothalamus leiocarpus of the Annonaceae family is used as an alternative medicine in tropical regions. Applying high-speed counter current chromatography (HSCCC), eight new bioactive styrylpyrone isomers, including 6 R ,7 S ,8 R ,2' S -goniolactone B ( 1 ), 6 S ,7 S ,8 S ,2' S -goniolactone B ( 2 ), 6 R ,7 R ,8 R ,2' S -goniolactone B ( 3 ), 6 R ,7 S ,8 S ,2' S -goniolactone C ( 4 ), 6 R ,7 S ,8 R ,2' S -goniolactone C ( 5 ), 6 S ,7 R ,8 S ,2' S -goniolactone C ( 6 ), and two positional isomers, 6 R ,7 R ,8 R ,2' S -goniolactone G ( 7 ) and 6 S ,7 R ,8 R ,2' S -goniolactone G ( 8 ), were isolated from a chloroform fraction (2...
March 27, 2024: Journal of Natural Products
https://read.qxmd.com/read/38536889/multilocus-sequence-typing-and-antibiotic-resistance-of-aeromonas-isolated-from-freshwater-fish-in-hebei-province
#3
JOURNAL ARTICLE
Zixiao Yu, Yunseok Oh, Songmi Kim, Kyudong Han, Kornsorn Srikulnath, Qingyang Li, Ji-Seok Jang, Ho-Seong Lee
Aeromonas spp. are the opportunistic pathogens that infect both aquatic and terrestrial homeotherms. They were commonly present in aquatic environments, including effluent, tap water, marine, river, and lake, where they are often isolated from aquatic animals, including fish, molluscs, and crustaceans. The Aeromonas infections can cause sepsis, ulcer, and other symptoms, resulting in the death of massive aquatic animals. Therefore, the prevention and control of Aeromonas is of great significance for the healthy development of aquaculture...
2024: PloS One
https://read.qxmd.com/read/38536646/impact-of-immunosuppressed-status-on-prognosis-of-carbapenem-resistant-organisms-bloodstream-infections
#4
JOURNAL ARTICLE
Yuan-Yuan Li, Yan Chen, Shan Li, Yuan-Yuan Li, Ran An, Xiao-Yun Hu, Wei Jiang, Chun-Yao Wang, Run Dong, Qi-Wen Yang, Li Weng, Jin-Min Peng, Bin Du
INTRODUCTION: The impact of immunosuppression on prognosis of carbapenem-resistant organism (CRO) bloodstream infection (BSI) remains unclear. The aim of this study was to clarify the relationship between immunosuppression and mortality of CRO-BSI and to identify the risk factors associated with mortality in immunosuppressed patients. METHODS: This retrospective study included 279 patients with CRO-BSI from January 2018 to March 2023. Clinical characteristics and outcomes were compared between the immunosuppressed and immunocompetent patients...
March 27, 2024: Infectious Diseases and Therapy
https://read.qxmd.com/read/38536433/immobilised-antimicrobial-peptides-in-downregulation-of-biofilm
#5
REVIEW
Moupriya Nag, Debasmita Bhattacharya, Sayantani Garai, Bandita Dutta, Sreejita Ghosh, Rina Rani Ray, Dibyajit Lahiri
Colonisation of sessile bacterial species on biotic and abiotic surfaces is responsible for the development of various infections in humans. At present, biofilm-associated chronic infections have been a prime concern among the healthcare practitioners since they are impermeable to drugs, resulting in the development of antibiotic resistance or multi-drug resistance. For a few decades, a lot of research activity has been performed in the development of alternative therapeutics to combat biofilm-associated chronic infections...
March 27, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38536098/-escherichia-coli-isolated-from-bovine-sources-encoding-the-fosfomycin-resistance-gene-fosa7-5
#6
JOURNAL ARTICLE
Bradd J Haley, Seon Woo Kim, Jo Ann Van Kessel
Dairy animals are reservoirs of antimicrobial-resistant Escherichia coli that are frequently resistant to tetracycline, aminoglycoside, β-lactam, sulfonamide, and macrolide-lincosamide-streptogramin B antibiotics. However, resistance to other classes of antimicrobials is less frequently observed, and resistance to fosfomycin is rarely observed in E. coli . In this study, we describe the genomic characteristics of E. coli encoding fosA7.5 that have been recovered from bovine sources in the United States...
March 27, 2024: Foodborne Pathogens and Disease
https://read.qxmd.com/read/38536055/predicting-increased-incidence-of-common-antibiotic-resistant-and-antibiotic-associated-pathogens-using-ensemble-species-distribution-modeling
#7
JOURNAL ARTICLE
Siqi C Brough, Luke Caddell, Raymond J Liou, Advait Patil, Giulio De Leo, Joseph D Forrester
The Centers for Disease Control estimates antibiotic-associated pathogens result in 2.8 million infections and 38,000 deaths annually in the United States. This study applies species distribution modeling to elucidate the impact of environmental determinants of human infectious disease in an era of rapid global change. We modeled methicillin-resistant Staphylococcus aureus and Clostridioides difficile using 31 publicly accessible bioclimatic, healthcare, and sociodemographic variables. Ensemble models were created from 8 unique statistical and machine learning algorithms...
March 27, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38535888/characteristics-of-pathogenic-escherichia-coli-associated-with-diarrhea-in-children-under-five-years-in-northwestern-ethiopia
#8
JOURNAL ARTICLE
Berihun Mossie Mulu, Mequanint Addisu Belete, Tiliksew Bialfew Demlie, Habtamu Tassew, Tesfaye Sisay Tessema
Diarrheagenic Escherichia coli (DEC) are the leading cause of infectious diarrhea and pose a significant global, regional, and national burden of disease. This study aimed to investigate the prevalence of six DEC pathotypes in children with diarrhea and determine their antibiotic resistance patterns. Samples from 107 diarrheagenic children were collected and processed for Escherichia coli ( E. coli ). Single-plex PCR was used to detect target virulence genes as well as characterize and categorize DEC pathotypes...
March 21, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535887/multiple-drug-resistant-shiga-toxin-producing-e-coli-in-raw-milk-of-dairy-bovine
#9
JOURNAL ARTICLE
Safir Ullah, Saeed Ul Hassan Khan, Muhammad Jamil Khan, Baharullah Khattak, Fozia Fozia, Ijaz Ahmad, Mohammad Ahmad Wadaan, Muhammad Farooq Khan, Almohannad Baabbad, Sagar M Goyal
INTRODUCTION: Raw milk may contain pathogenic microorganisms harmful to humans, e.g., multidrug-resistant Escherichia coli non-O157:H7, which can cause severe colitis, hemolytic uremia, and meningitis in children. No studies are available on the prevalence of Shiga toxin-producing E. coli (STEC O157:H7) in sick or healthy dairy animals in the Khyber Pakhtunkhwa Province of Pakistan. AIM: This study aimed to isolate, characterize, and detect antibiotic resistance in STEC non-O157:H7 from unpasteurized milk of dairy bovines in this province...
March 19, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535851/-histophilus-somni-as-a-unique-causative-agent-of-puerperal-metritis-pm-in-a-third-lactation-holstein-cow
#10
Jéssica Molín, Andrea Ainoza, Ramon Armengol
This manuscript aims to report the clinical and laboratory diagnosis of puerperal metritis (PM) in a dairy cow, caused by H. somni as a unique pathogen. The cow showed signs of systemic illness, including a sudden drop in milk production, a rectal temperature of 40.4 °C, tachypnea, dehydration, and completely fluid, brown, and fetid uterine discharge. Pure cultures of H. somni were identified and submitted to the Kirby-Bauer disc diffusion method for antibiotic sensitivity. The study showed that H. somni was resistant to tetracyclines and cephalosporins (Ceftiofur), antibiotics commonly used to treat uterine infections in dairy cows...
March 5, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535822/cationicity-enhancement-on-the-hydrophilic-face-of-ctriporin-significantly-reduces-its-hemolytic-activity-and-improves-the-antimicrobial-activity-against-antibiotic-resistant-eskape-pathogens
#11
JOURNAL ARTICLE
Xudong Luo, Huan Deng, Li Ding, Xiangdong Ye, Fang Sun, Chenhu Qin, Zongyun Chen
The ESKAPE pathogen-associated antimicrobial resistance is a global public health issue, and novel therapeutic strategies are urgently needed. The short cationic antimicrobial peptide (AMP) family represents an important subfamily of scorpion-derived AMPs, but high hemolysis and poor antimicrobial activity hinder their therapeutic application. Here, we recomposed the hydrophilic face of Ctriporin through lysine substitution. We observed non-linear correlations between the physiochemical properties of the peptides and their activities, and significant deviations regarding the changes of antimicrobial activities against different bacterial species, as well as hemolytic activity...
March 18, 2024: Toxins
https://read.qxmd.com/read/38535816/diversity-and-molecular-evolution-of-antimicrobial-peptides-in-caecilian-amphibians
#12
JOURNAL ARTICLE
Mario Benítez-Prián, Héctor Lorente-Martínez, Ainhoa Agorreta, David J Gower, Mark Wilkinson, Kim Roelants, Diego San Mauro
Antimicrobial peptides (AMPs) are key molecules in the innate immune defence of vertebrates with rapid action, broad antimicrobial spectrum, and ability to evade pathogen resistance mechanisms. To date, amphibians are the major group of vertebrates from which most AMPs have been characterised, but most studies have focused on the bioactive skin secretions of anurans (frogs and toads). In this study, we have analysed the complete genomes and/or transcriptomes of eight species of caecilian amphibians (order Gymnophiona) and characterised the diversity, molecular evolution, and antimicrobial potential of the AMP repertoire of this order of amphibians...
March 14, 2024: Toxins
https://read.qxmd.com/read/38535563/lung-microbiota-and-ventilator-associated-pneumonia-in-the-neonatal-period
#13
REVIEW
Fermín García-Muñoz Rodrigo, Lourdes Urquía Martí, Marta Siguero Onrubia, Moreyba Borges Luján, Gloria Galán Henríquez, Desiderio Reyes Suárez
The lung microbiota is a complex community of microorganisms that colonize the respiratory tract of individuals from, or even before, birth. Although the lungs were traditionally believed to be sterile, recent research has shown that there is a diversity of bacterial species in the respiratory system. Knowledge about the lung microbiota in newborns and its relationship with bacterial infections is of vital importance to understand the pathogenesis of respiratory diseases in neonatal patients undergoing mechanical ventilation...
March 1, 2024: Pathogens
https://read.qxmd.com/read/38535544/pathogens-causing-pediatric-community-acquired-urinary-tract-infections-and-their-increasing-antimicrobial-resistance-a-nationwide-study
#14
JOURNAL ARTICLE
Vered Shkalim Zemer, Shai Ashkenazi, Yoel Levinsky, Yael Richenberg, Eyal Jacobson, Shay Nathanson, Tzippy Shochat, Shiri Kushnir, Moriya Cohen, Avner Herman Cohen
Urinary tract infections (UTIs) in childhood are common and are associated with considerable acute morbidity and long-term complications. The need for updated data to optimize empiric antibiotic therapy is crucial. We aimed to investigate the pathogens causing pediatric community acquired UTIs, their correlation with demographic characteristics, and trends in their antimicrobial resistance. This nationwide cross-sectional study included all 53,203 children (<18 years) diagnosed with UTI in community outpatient clinics in the following selected years: 2007, 2011, 2015, 2019 and 2021...
February 24, 2024: Pathogens
https://read.qxmd.com/read/38535540/types-and-mechanisms-of-efflux-pump-systems-and-the-potential-of-efflux-pump-inhibitors-in-the-restoration-of-antimicrobial-susceptibility-with-a-special-reference-to-acinetobacter-baumannii
#15
REVIEW
Kira M Zack, Trent Sorenson, Suresh G Joshi
Bacteria express a plethora of efflux pumps that can transport structurally varied molecules, including antimicrobial agents and antibiotics, out of cells. Thus, efflux pump systems participate in lowering intracellular concentrations of antibiotics, which allows phenotypic multidrug-resistant (MDR) bacteria to survive effectively amid higher concentrations of antibiotics. Acinetobacter baumannii is one of the classic examples of pathogens that can carry multiple efflux pump systems, which allows these bacteria to be MDR-to-pan-drug resistant and is now considered a public health threat...
February 23, 2024: Pathogens
https://read.qxmd.com/read/38535533/new-frontier-on-antimicrobial-therapy-long-acting-lipoglycopeptides
#16
REVIEW
Valentina Siciliano, Flavio Sangiorgi, Pierluigi Del Vecchio, Layla Vahedi, Maya Manuela Gross, Angela Saviano, Veronica Ojetti
Long-acting lipoglycopeptides (LGPs), such as dalbavancin and oritavancin, are semisynthetic antibiotics known for their strong effectiveness against a wide array of Gram-positive bacteria. This includes Staphylococcus aureus , both methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) strains, coagulase-negative Staphylococci (CoNS), streptococci, and vancomycin-sensitive Enterococcus faecalis . A literature search was conducted on PubMed and on ClinicalTrials.gov to identify articles published until July 2023 investigating the use of oritavancin and dalbavancin in clinical practice...
February 20, 2024: Pathogens
https://read.qxmd.com/read/38535514/pediatric-lemierre-s-syndrome-a-comprehensive-literature-review
#17
REVIEW
Salvatore Lavalle, Edoardo Masiello, Salvatore Cocuzza, Piero Pavone, Alessandra Di Nora, Christian Calvo-Henriquez, Jerome Rene Lechien, Miguel Mayo Yanez, Andrea Praticò, Manuela Ceccarelli, Giannicola Iannella, Annalisa Pace, Federica Maria Parisi, Giuseppe Magliulo, Antonino Maniaci
BACKGROUND: Lemierre syndrome is a rare, potentially fatal complication of oropharyngeal infections characterized by septic thrombophlebitis of the internal jugular vein. It primarily affects healthy adolescents and young adults. Its incidence declined after the antibiotic era, but it may have resurged in recent decades, likely due to judicious antibiotic use and increasing bacterial resistance. Prompt diagnosis and treatment are imperative to prevent significant morbidity and mortality...
March 18, 2024: Pediatric Reports
https://read.qxmd.com/read/38535266/antibacterial-and-antibiofouling-activities-of-carbon-polymerized-dots-polyurethane-and-c-60-polyurethane-composite-films
#18
JOURNAL ARTICLE
Zoran M Marković, Milica D Budimir Filimonović, Dušan D Milivojević, Janez Kovač, Biljana M Todorović Marković
The cost of treatment of antibiotic-resistant pathogens is on the level of tens of billions of dollars at the moment. It is of special interest to reduce or solve this problem using antimicrobial coatings, especially in hospitals or other healthcare facilities. The bacteria can transfer from medical staff or contaminated surfaces to patients. In this paper, we focused our attention on the antibacterial and antibiofouling activities of two types of photodynamic polyurethane composite films doped with carbon polymerized dots (CPDs) and fullerene C60 ...
March 17, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535053/a-web-based-dynamic-nomogram-to-predict-the-risk-of-methicillin-resistant-staphylococcal-infection-in-patients-with-pneumonia
#19
JOURNAL ARTICLE
Van Duong-Thi-Thanh, Binh Truong-Quang, Phu Tran-Nguyen-Trong, Mai Le-Phuong, Phu Truong-Thien, Dung Lam-Quoc, Thong Dang-Vu, Minh-Loi Nguyen, Vu Le-Thuong
The aim of this study was to create a dynamic web-based tool to predict the risks of methicillin-resistant Staphylococcus spp. (MRS) infection in patients with pneumonia. We conducted an observational study of patients with pneumonia at Cho Ray Hospital from March 2021 to March 2023. The Bayesian model averaging method and stepwise selection were applied to identify different sets of independent predictors. The final model was internally validated using the bootstrap method. We used receiver operator characteristic (ROC) curve, calibration, and decision curve analyses to assess the nomogram model's predictive performance...
March 16, 2024: Diagnostics
https://read.qxmd.com/read/38534839/use-of-biomaterials-in-3d-printing-as-a-solution-to-microbial-infections-in-arthroplasty-and-osseous-reconstruction
#20
REVIEW
Argyrios Periferakis, Aristodemos-Theodoros Periferakis, Lamprini Troumpata, Serban Dragosloveanu, Iosif-Aliodor Timofticiuc, Spyrangelos Georgatos-Garcia, Andreea-Elena Scheau, Konstantinos Periferakis, Ana Caruntu, Ioana Anca Badarau, Cristian Scheau, Constantin Caruntu
The incidence of microbial infections in orthopedic prosthetic surgeries is a perennial problem that increases morbidity and mortality, representing one of the major complications of such medical interventions. The emergence of novel technologies, especially 3D printing, represents a promising avenue of development for reducing the risk of such eventualities. There are already a host of biomaterials, suitable for 3D printing, that are being tested for antimicrobial properties when they are coated with bioactive compounds, such as antibiotics, or combined with hydrogels with antimicrobial and antioxidant properties, such as chitosan and metal nanoparticles, among others...
March 1, 2024: Biomimetics
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