keyword
MENU ▼
Read by QxMD icon Read
search

Antibiotic Resistance

keyword
https://www.readbyqxmd.com/read/29054003/adhesion-force-sensing-and-activation-of-a-membrane-bound-sensor-to-activate-nisin-efflux-pumps-in-staphylococcus-aureus-under-mechanical-and-chemical-stresses
#1
Vera Carniello, Akshay K Harapanahalli, Henk J Busscher, Henny C van der Mei
Nisin-associated-sensitivity-response-regulator (NsaRS) in Staphylococcus aureus is important for its adhesion to surfaces and resistance against antibiotics, like nisin. NsaRS consists of an intra-membrane-located sensor NsaS and a cytoplasmatically-located response-regulator NsaR, which becomes activated upon receiving phosphate groups from the intra-membrane-located sensor. HYPOTHESIS: The intra-membrane location of the NsaS sensor leads us to hypothesize that the two-component NsaRS system not only senses "chemical" (nisin) but also "mechanical" (adhesion) stresses to modulate efflux of antibiotics from the cytoplasm...
October 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29053557/bacterial-keratitis-isolated-organisms-and-antibiotic-resistance-patterns-in-san-francisco
#2
Michelle Y Peng, Vicky Cevallos, Stephen D McLeod, Thomas M Lietman, Jennifer Rose-Nussbaumer
PURPOSE: Understanding the spectrum of pathogens in a given geographic region is important when deciding on empiric antibiotic therapy. In this study, we evaluate the spectrum of bacterial organisms cultured from corneal samples and their antibiotic sensitivities to guide initial treatment of keratitis. METHODS: We performed a retrospective case review of cultures from suspected infectious keratitis cases at the Francis I. Proctor Foundation, University of California, San Francisco, from 1996 through 2015...
October 17, 2017: Cornea
https://www.readbyqxmd.com/read/29052797/suppressive-antibiotic-therapy-with-oral-tetracyclines-for-prosthetic-joint-infections-a-retrospective-study-of-78-patients
#3
M Pradier, O Robineau, A Boucher, M Titecat, N Blondiaux, M Valette, C Loïez, E Beltrand, S Nguyen, H Dézeque, H Migaud, Eric Senneville
PURPOSE: This study aimed at describing the use of oral cyclines (i.e., doxycycline and minocycline) as suppressive antibiotic therapy (SAT) in patients with periprosthetic joint infections (PJIs). METHODS: Medical charts of all patients with surgical revisions for PJIs who were given cycline-based SAT because of a high failure of various origins were reviewed. Data regarding tolerability and effectiveness of cycline-based SAT were analysed. RESULTS: Seventy-eight patients of mean age 64 ± 17 years received cycline-base SAT in the period from January 2006 to January 2014...
October 20, 2017: Infection
https://www.readbyqxmd.com/read/29052326/effects-of-the-antimicrobial-peptide-protegrine-1-on-sperm-viability-and-bacterial-load-of-boar-seminal-doses
#4
S Sancho, M Briz, M Yeste, S Bonet, E Bussalleu
The presence of bacteria adversely affects boar sperm quality of seminal doses intended for artificial insemination. Currently, the most common measure to prevent bacteriospermia is the addition of antibiotics in semen extenders; however, mounting evidence shows that microbial resistance exists. A promising alternative to replace antibiotics are antimicrobial peptides. In this study, the effects of the antimicrobial peptide protegrine 1 (PG1) on the sperm viability and bacterial load of boar seminal doses were evaluated...
October 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29052092/a-72-h-intervention-for-improvement-of-the-rate-of-optimal-antibiotic-therapy-in-patients-with-bloodstream-infections
#5
R Murri, F Taccari, T Spanu, T D'Inzeo, I Mastrorosa, F Giovannenze, G Scoppettuolo, G Ventura, C Palazzolo, M Camici, S Lardo, B Fiori, M Sanguinetti, R Cauda, M Fantoni
Antimicrobial stewardship programs are implemented to optimize the use of antibiotics and control the spread of antibiotic resistance. Many antimicrobial stewardship interventions have demonstrated significant efficacy in reducing unnecessary prescriptions of antibiotics, the duration of antimicrobial therapy, and mortality. We evaluated the benefits of a combination of rapid diagnostic tests and an active re-evaluation of antibiotic therapy 72 h after the onset of bloodstream infection (BSI). All patients with BSI from November 2015 to November 2016 in a 1100-bed university hospital in Rome, where an Infectious Disease Consultancy Unit (Unità di Consulenza Infettivologica, UDCI) is available, were re-evaluated at the bedside 72 h after starting antimicrobial therapy and compared to two pre-intervention periods: the UDCI was called by the ward physician for patients with BSI and the UDCI was called directly by the microbiologist immediately after a pathogen was isolated from blood cultures...
October 19, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29051752/icesag37-a-novel-integrative-and-conjugative-element-carrying-antimicrobial-resistance-genes-and-potential-virulence-factors-in-streptococcus-agalactiae
#6
Kaixin Zhou, Lianyan Xie, Lizhong Han, Xiaokui Guo, Yong Wang, Jingyong Sun
ICESag37, a novel integrative and conjugative element carrying multidrug resistance and potential virulence factors, was characterized in a clinical isolate of Streptococcus agalactiae. Two clinical strains of S. agalactiae, Sag37 and Sag158, were isolated from blood samples of new-borns with bacteremia. Sag37 was highly resistant to erythromycin and tetracycline, and susceptible to levofloxacin and penicillin, while Sag158 was resistant to tetracycline and levofloxacin, and susceptible to erythromycin. Transfer experiments were performed and selection was carried out with suitable antibiotic concentrations...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29051747/pirab-vp-bearing-vibrio-parahaemolyticus-and-vibrio-campbellii-pathogens-isolated-from-the-same-ahpnd-affected-pond-possess-highly-similar-pathogenic-plasmids
#7
Xuan Dong, Dexi Bi, Hailiang Wang, Peizhuo Zou, Guosi Xie, Xiaoyuan Wan, Qian Yang, Yanping Zhu, Mengmeng Chen, Chengcheng Guo, Zhen Liu, Wenchao Wang, Jie Huang
Acute hepatopancreatic necrosis disease (AHPND) is a severe shrimp disease originally shown to be caused by virulent strains of Vibrio parahaemolyticus (VPAHPND). Rare cases of AHPND caused by Vibrio species other than V. parahaemolyticus were reported. We compared an AHPND-causing V. campbellii (VCAHPND) and a VPAHPND isolate from the same AHPND-affected pond. Both strains are positive for the virulence genes pirAB(vp) . Immersion challenge test with Litopenaeus vannamei indicated the two strains possessed similar pathogenicity...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29051656/antimicrobial-resistance-in-diarrheagenic-escherichia-coli-from-ready-to-eat-foods
#8
Cíntia Matos Lima, Ingrid Evelyn Gomes Lima Souza, Taila Dos Santos Alves, Clícia Capibaribe Leite, Norma Suely Evangelista-Barreto, Rogeria Comastri de Castro Almeida
Certain subgroups of Escherichia coli have congenital or acquired virulence properties that allow them to cause a wide spectrum of disease. The aim of this study was to investigate the occurrence of diarrheagenic E. coli strains in ready-to-eat (RTE) foods produced in institutional, commercial and hotel restaurants in Salvador, Brazil. The presence of virulent isolates and antimicrobial resistance were evaluated. Four hundred forty-six samples were collected and grouped into cereals and vegetables, meat-based preparations, cooked salads, raw salads, garnishes, soups and sauces, desserts and juices...
October 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29051620/antimicrobial-peptide-loaded-gold-nanoparticle-dna-aptamer-conjugates-as-highly-effective-antibacterial-therapeutics-against-vibrio-vulnificus
#9
Boeun Lee, Jonggwan Park, Minkyung Ryu, Soochan Kim, Minju Joo, Ji-Hyun Yeom, Suk Kim, Yoonkyung Park, Kangseok Lee, Jeehyeon Bae
Vibrio vulnificus causes fatal infections in humans, and antibiotics are commonly used in treatment regimens against V. vulnificus infection. However, the therapeutic effects of antibiotics are limited by multidrug resistance. In this study, we demonstrated that an antimicrobial peptide (AMP), HPA3P(His), loaded onto a gold nanoparticle-DNA aptamer (AuNP-Apt) conjugate (AuNP-Apt-HPA3P(His)) is an effective therapeutic tool against V. vulnificus infection in vivo in mice. HPA3P(His) induced bacterial cell death through the disruption of membrane integrity of V...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051379/ectopic-colonization-of-oral-bacteria-in-the-intestine-drives-th1-cell-induction-and-inflammation
#10
Koji Atarashi, Wataru Suda, Chengwei Luo, Takaaki Kawaguchi, Iori Motoo, Seiko Narushima, Yuya Kiguchi, Keiko Yasuma, Eiichiro Watanabe, Takeshi Tanoue, Christoph A Thaiss, Mayuko Sato, Kiminori Toyooka, Heba S Said, Hirokazu Yamagami, Scott A Rice, Dirk Gevers, Ryan C Johnson, Julia A Segre, Kong Chen, Jay K Kolls, Eran Elinav, Hidetoshi Morita, Ramnik J Xavier, Masahira Hattori, Kenya Honda
Intestinal colonization by bacteria of oral origin has been correlated with several negative health outcomes, including inflammatory bowel disease. However, a causal role of oral bacteria ectopically colonizing the intestine remains unclear. Using gnotobiotic techniques, we show that strains of Klebsiella spp. isolated from the salivary microbiota are strong inducers of T helper 1 (TH1) cells when they colonize in the gut. These Klebsiella strains are resistant to multiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe gut inflammation in the context of a genetically susceptible host...
October 20, 2017: Science
https://www.readbyqxmd.com/read/29051236/first-complete-genome-sequence-of-methicillin-resistant-staphylococcus-aureus-strain-so-1977-isolated-from-khartoum-sudan
#11
Sofia B Mohamed, Mohamed S Ali, Faisal M Alamir, Tahani B Alyas, Abdallah E Ahmed, Almeen O Seed, Rihab A Omer
Methicillin-resistant Staphylococcus aureus is increasingly becoming resistant to most antibiotics and consequently has become a challenging public health problem in Sudan. The present study documented the first complete genome sequence of strain SO-1977, isolated from a contaminated wound in Sudan.
October 19, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29051234/draft-genome-sequence-of-a-salmonella-enterica-serovar-typhi-strain-resistant-to-fourth-generation-cephalosporin-and-fluoroquinolone-antibiotics
#12
Danish Gul, Robert F Potter, Hurmat Riaz, Shifa Tariq Ashraf, Meghan A Wallace, Tehmina Munir, Amjad Ali, C A Burnham, Gautam Dantas, Saadia Andleeb
Typhoid is endemic in developing countries. We report here the first draft genome sequence of a Salmonella enterica serovar Typhi clinical isolate from Pakistan exhibiting resistance to cefepime (a fourth-generation cephalosporin) and fluoroquinolone antibiotics, two of the last-generation therapies against this pathogen. The genome is ~4.8 Mb, with two putative plasmids.
October 19, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29051020/draft-genome-sequences-of-three-multidrug-resistant-cutibacterium-formerly-propionibacterium-acnes-strains-isolated-from-acne-patients-china
#13
Nanxue Zhang, Zhong Lu, Ying Ma
OBJECTIVES: Cutibacterium acnes (formerly Propionibacterium acnes), an anaerobic Gram-positive bacterium, is a skin commensal and considered to be associated with acne. Here we report draft genome sequences of three multidrug-resistant C. acnes strains (CA17, CA39, and CA51), isolated from skin lesions of acne patients from China. METHODS: The whole genome of the three multidrug-resistant C. acnes strains were sequenced using an Illumina HiSeq 2500 platform. De novo assembly and annotation were performed with SPAdes-3...
October 16, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29050887/antibiotic-stewardship-in-the-newborn-surgical-patient-a%C3%A2-quality-improvement-project-in-the-neonatal-intensive-care-unit
#14
Sarah Walker, Ankur Datta, Roxanne L Massoumi, Erica R Gross, Michael Uhing, Marjorie J Arca
BACKGROUND: There is significant diversity in the utilization of antibiotics for neonates undergoing surgical procedures. Our institution standardized antibiotic administration for surgical neonates, in which no empiric antibiotics were given to infants with surgical conditions postnatally, and antibiotics are given no more than 72 hours perioperatively. METHODS: We compared the time periods before and after implementation of antibiotic protocol in an institution review board-approved, retrospective review of neonates with congenital surgical conditions who underwent surgical correction within 30 days after birth...
October 16, 2017: Surgery
https://www.readbyqxmd.com/read/29050864/outpatient-parenteral-antibiotic-therapy-evaluation-of-practices-and-limits-of-use-in-rural-areas-in-france
#15
C Triffault-Fillit, T Ferry, T Perpoint, L Adélaïde, S Le Ngoc Tho, F Ader, C Chidiac, F Valour
OBJECTIVES: To evaluate outpatient parenteral antibiotic therapy (OPAT) practices in a French rural area. MATERIAL AND METHODS: Descriptive study assessing knowledge, practices, and limitations of OPAT use among hospital practitioners (HP), family physicians (FP), and private nurses (PN). RESULTS: OPAT (mainly ceftriaxone and penicillins) was used by 69.6%, 73.3%, and 97.7% of the 23 HPs, 45 FPs, and 46 PNs mostly for respiratory or urinary tract infections, bacteremia, and/or multidrug-resistant bacterial infections...
October 16, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29050768/single-nucleotide-polymorphisms-in-efflux-pumps-genes-in-extensively-drug-resistant-mycobacterium-tuberculosis-isolates-from-pakistan
#16
Akbar Kanji, Rumina Hasan, Asho Ali, Ambreen Zaver, Ying Zhang, Kehkashan Imtiaz, Wanliang Shi, Taane G Clark, Ruth McNerney, Jody Phelan, Shoaib Rao, Samreen Shafiq, Zahra Hasan
It is challenging to understand mechanisms of drug resistance in Mycobacterium tuberculosis (MTB) due to the large variability in resistance associated genes. Efflux pump genes contribute to drug resistance and thus add to this complexity. Efflux pump gene protein superfamilies have been characterized by genome analysis of drug resistant strains and through in vitro transcriptional studies. However, there is limited information regarding efflux pump genes in extensively drug resistant (XDR) tuberculosis (TB) isolates...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29050760/mmps5-mmpl5-as-an-efflux-pump-in-mycobacterium-species
#17
REVIEW
Julien Briffotaux, Wei Huang, Xinwei Wang, Brigitte Gicquel
Tuberculosis remains an important cause of morbidity and mortality throughout the world, amplified by the expansion of antibiotic resistance. Increasing active efflux of the antibiotic is one of the several strategies used by bacteria to resist to antibiotics. After showing the importance of the RND superfamily of efflux pumps in drug resistance, this review focuses on the protein MmpL5, a transmembrane transporter of Mycobacterium. These exporters should be involved in the variety of roles in bacterial cells, including expelling various drugs...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29050757/ionophore-a23187-shows-anti-tuberculosis-activity-and-synergy-with-tebipenem
#18
Wei Huang, Julien Briffotaux, Xinwei Wang, Lili Liu, Pei Hao, Mena Cimino, Maria Virginia Buchieri, Amine Namouchi, Jose-Antonio Ainsa, Brigitte Gicquel
The objective of this study was to find molecules with anti-mycobacterial activity from a natural compounds library, investigate their mechanisms of resistance, and assess their synergy with antibiotics. We screened a library of 2582 natural compounds with Mycobacterium aurum with the aim of identifying molecules with anti-mycobacterial activity. The hits with the lowest MICs in M. aurum were also tested for their antimicrobial activity in other mycobacterial species including M. tuberculosis complex strains...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29050604/chitosan-as-an-effective-inhibitor-of-multidrug-resistant-acinetobacter-baumannii
#19
E M Costa, S Silva, S Vicente, M Veiga, F Tavaria, M M Pintado
Over the last two decades worldwide levels of antibiotic resistance have risen leading to the appearance of multidrug resistant microorganisms. Acinetobacter baumannii is a known skin pathogen which has emerged as a major cause of nosocomial outbreaks due to its capacity to colonize indwelling medical devices and natural antibiotic resistance. With chitosan being an effective antimicrobial agent against antibiotic resistant microorganisms, the aim of this work was to access its potential as an alternative to traditional antimicrobials in the management of A...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29050550/potential-changes-in-chemical-soil-quality-resulting-from-graywater-recycling-for-landscape-irrigation
#20
(no author information available yet)
The effects of graywater irrigation on soil chemical properties and accumulation of surfactants and antimicrobials wereinvestigated at three households in Arizona, California and Colorado over the duration of two to three years. No negative impacts were observed with respect to sodium and boron accumulation in soil over the duration of this study. Graywater irrigation significantly increased organic matter and total inorganic nitrogen of the receiving soil (P<0.05). Graywater loading rates and fertilizer application should be monitored to ensure that excessive amount of nitrogen and phosphorus are not applied to the soil...
October 13, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
keyword
keyword
178
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"