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https://www.readbyqxmd.com/read/29778482/randomized-noninferiority-field-trial-evaluating-cephapirin-sodium-for-treatment-of-nonsevere-clinical-mastitis
#1
T Tomazi, T A F Lopes, V Masson, J M Swinkels, M V Santos
The general objective of this study was to evaluate whether cephapirin sodium is noninferior compared with a positive control broad-spectrum product formulated with a combination of antimicrobials for intramammary treatment of nonsevere clinical mastitis. In addition, we compared the efficacy of treatments on the cure risks of pathogen groups (gram-positive, gram-negative, and cultures with no growth) based on culture results. A total of 346 cows distributed in 31 commercial dairy herds were selected to participate in the study, although only 236 met the criteria for evaluation of microbiological cure...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29773886/pretreatment-with-broad-spectrum-antibiotics-alters-the-pharmacokinetics-of-major-constituents-of-shaoyao-gancao-decoction-in-rats-after-oral-administration
#2
Meng Liu, Jie Yuan, Wen-Juan Hu, Chang-Qiang Ke, Yi-Fan Zhang, Yang Ye, Da-Fang Zhong, Guang-Rong Zhao, Sheng Yao, Jia Liu
The influence of broad-spectrum antibiotics on the pharmacokinetics and biotransformation of major constituents of Shaoyao-Gancao decoction (SGD) in rats was investigated. The pharmacokinetic behaviors of paeoniflorin (PF), albiflorin (AF), liquiritin (LT), isoliquiritin (ILT), liquiritin apioside (LA), isoliquiritin apioside (ILA), and glycyrrhizic acid (GL), seven major constituents of SGD, as well as glycyrrhetinic acid (GA), a major metabolite of GL, were analyzed. A 1-week pretreatment with broad-spectrum antibiotics (ampicillin, metronidazole, neomycin, 1 g L-1 ; and vancomycin, 0...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29770869/curcumin-inhibits-autocrine-growth-hormone-mediated-invasion-and-metastasis-by-targeting-nf-%C3%AE%C2%BAb-signaling-and-polyamine-metabolism-in-breast-cancer-cells
#3
Ajda Coker-Gurkan, Merve Celik, Merve Ugur, Elif-Damla Arisan, Pinar Obakan-Yerlikaya, Zeynep Begum Durdu, Narcin Palavan-Unsal
Curcumin is assumed to be a plant-derived therapeutic drug that triggers apoptotic cell death in vitro and in vivo by affecting different molecular targets such as NF-κB. Phase I/II trial of curcumin alone or with chemotherapeutic drugs has been accomplished in pancreatic, colon, prostate and breast cancer cases. Recently, autocrine growth hormone (GH) signaling-induced cell growth, metastasis and drug resistance have been demonstrated in breast cancer. In this study, our aim was to investigate the potential therapeutic effect of curcumin by evaluating the molecular machinery of curcumin-triggered apoptotic cell death via focusing on NF-κB signaling and polyamine (PA) metabolism in autocrine GH-expressing MCF-7, MDA-MB-453 and MDA-MB-231 breast cancer cells...
May 16, 2018: Amino Acids
https://www.readbyqxmd.com/read/29766368/systemic-contact-dermatitis
#4
REVIEW
Marcella Aquino, Greg Rosner
Systemic contact dermatitis (SCD) traditionally refers to a skin condition where an individual who is cutaneously sensitized to an allergen will subsequently react to that same allergen or a cross reacting allergen via a different route. It occurs to allergens including metals, medications, and foods. The exact pathophysiology underlying this disease remains unknown, although it appears to be mediated by type 4 hypersensitivity reactions and possibly type 3 hypersensitivity reactions. The p-I concept (pharmacologic interaction with immunoreceptors) hypothesized that drugs are able to bind directly to a T cell receptor without first being presented by MHC (major histocompatibility complex) molecules and without prior metabolism, which would help explain why SCD can be seen on first exposure to medications...
May 15, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29763981/antibacterial-activity-of-cladanthus-arabicus-and-bubonium-imbricatum-essential-oils-alone-and-in-combination-with-conventional-antibiotics-against-enterobacteriaceae-isolates
#5
Abdellah Aghraz, Qada Benameur, Teresa Gervasi, Loubna Ait Dra, Meriem Hind Ben-Mahdi, Mustapha Larhsini, Mohamed Markouk, Nicola Cicero
Multidrug-resistant bacteria have become common all over the world, necessitating the development of new therapeutic strategies. Synergistic interactions between conventional antibiotics and natural bioactive may have therapeutic benefits in a clinical setting. There are plenty of medicinal plants that have proven efficacy against broad spectrum of microorganisms. The aim of the work was to assess the antibacterial activity of Cladanthus arabicus, a Moroccan medicinal plant, and Bubonium imbricatum, a Moroccan endemic plant...
May 15, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29762756/prevalence-antimicrobial-resistance-profile-and-comparison-of-selective-plating-media-for-the-isolation-of-salmonella-spp-in-free-ranging-waterfowl-from-entre-rios-argentina
#6
F I Rodríguez, J M Osinalde, S C Gómez, D G Pulido, M I Caffer, F C Nicolau, D J Bueno
The present study was conducted to estimate the apparent prevalence of Salmonella spp. in free-ranging waterfowl that inhabitant Entre Ríos, Argentina, determine the antimicrobial resistance of the isolated, and compare the performance of two selective plating media used for Salmonella isolation. Five hundred ninety nine free-living waterfowl were sampled one time by cloacal swab from April 2014 to July 2016. Only 6 samples from waterfowl belonged to all counties sampled were positive to Salmonella spp., so the apparent prevalence was 1%...
May 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29736701/affinity-capillary-electrophoresis-for-identification-of-active-drug-candidates-in-myotonic-dystrophy-type-1
#7
Ioan O Neaga, Stephanie Hambye, Ede Bodoki, Claudio Palmieri, Eugénie Ansseau, Alexandra Belayew, Radu Oprean, Bertrand Blankert
Myotonic dystrophy type 1 (DM1) is an autosomal dominantly inherited degenerative disease with a slow progression. At the present, there is no commercially available treatment, but sustained effort is currently undertaken for the development of a promising lead compound. In the present paper we report the development of a fast, versatile, and cost-effective affinity capillary electrophoresis (ACE) method for the screening and identification of potential drug candidates targeting pathological ARN probes relevant for DM1...
May 8, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29727265/prevalence-of-aminoglycoside-modifying-enzymes-in-escherichia-coli-and-klebsiella-pneumoniae-producing-extended-spectrum-%C3%AE-lactamases-collected-in-two-multicenter-studies-in-spain
#8
Marta Fernández-Martínez, Belén Ruiz Del Castillo, Maria Jesús Lecea-Cuello, Jesús Rodríguez-Baño, Álvaro Pascual, Luis Martínez-Martínez
The in vitro activity of amikacin, gentamicin, kanamycin, tobramycin, neomycin, and netilmicin against 420 Escherichia coli producing extended spectrum β-lactamases (Ec-ESBLs) and 139 Klebsiella pneumoniae producing extended spectrum β-lactamase (Kp-ESBL) collected in two multicenter studies performed in Spain in 2000 and 2006 was determined. The presence of genes encoding aminoglycoside-modifying enzymes (AMEs) and 16S ribosomal RNA (rRNA) methylases [aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-Ib, ant(2")-Ia, ant(4')-IIa, aph(3')-Ia, aph(3')-IIa, armA, rmtB, and rmtC] was also investigated...
May 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29703354/50-years-ago-in-the-journal-of-pediatrics-comparison-of-orally-absorbable-and-nonabsorbable-antibiotics-in-shigellosis-a-double-blind-study-with-ampicillin-and-neomycin
#9
https://www.readbyqxmd.com/read/29687766/identification-and-prevalence-of-rnd-family-multidrug-efflux-pump-oqxab-genes-in-enterococci-isolates-from-swine-manure-in-china
#10
Li Yuan, Ya-Jun Zhai, Hua Wu, Hua-Run Sun, Zhi-Pei He, Ya-Bin Wang, Yu-Shan Pan, Nan-Nan Kuang, Gong-Zheng Hu
PURPOSE: The resistance/nodulation/cell division (RND) family multidrug efflux pump, OqxAB, has been identified as one of the leading mechanisms of plasmid-mediated quinolone resistance and has become increasingly prevalent among Enterobacteriaceae in recent years. However, oqxAB genes have not yet been reported in Enterococcus isolates. The aim of the present study was to identify the oqxAB genes and investigate their prevalence among Enterococcus from swine manure in China. METHODOLOGY: The oqxAB genes were screened in 87 Enterococcus isolates by PCR...
April 23, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29666764/evaluation-of-a-therapy-for-idiopathic-chronic-enterocolitis-in-rhesus-macaques-macaca-mulatta-and-linked-microbial-community-correlates
#11
Joshua M Taylor, Erik L Clarke, Kate Baker, Abigail Lauder, Dorothy Kim, Aubrey Bailey, Gary D Wu, Ronald G Collman, Lara Doyle-Meyers, Kasi Russell-Lodrigue, James Blanchard, Frederic D Bushman, Rudolf Bohm
Idiopathic chronic enterocolitis (ICE) is one of the most commonly encountered and difficult to manage diseases of captive rhesus macaques ( Macaca mulatta ). The etiology is not well understood, but perturbations in gut microbial communities have been implicated. Here we evaluated the effects of a 14-day course of vancomycin, neomycin, and fluconazole on animals affected with ICE, comparing treated, untreated, and healthy animals. We performed microbiome analysis on duodenal and colonic mucosal samples and feces in order to probe bacterial and/or fungal taxa potentially associated with ICE...
2018: PeerJ
https://www.readbyqxmd.com/read/29643295/prevalence-and-etiology-of-mastitis-in-dairy-cattle-in-el-oro-province-ecuador
#12
Said Amer, Fernando Lenin Aguilar Gálvez, Yasuhiro Fukuda, Chika Tada, Ivan Ludeña Jimenez, Wunster Favian Maza Valle, Yutaka Nakai
This study described the occurrence of clinical and subclinical forms of mastitis in 250 cattle from 5 dairy farms around the cities of Santa Rosa and Machala, El Oro Province, Ecuador. Clinical mastitis (CM) was determined based on obvious changes in milk (mild), signs of inflammation in the udder (moderate), and/or generalized clinical symptoms (severe). Subclinical mastitis (SCM) was assessed using the California mastitis test. CM and SCM were detected in 30 (12.0%) and 150 (60%) of the 250 tested cattle, respectively...
April 10, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29642832/-determination-of-the-role-of-salmonella-enterica-plasmids-in-antibiotic-susceptibility-and-caenorhabditis-elegans-pathogenicity
#13
Deniz Aksoy, Ece Şen
Poultry animals and poultry associated products are important risk sources for Salmonellosis. S.Kentucky and S.Infantis are among the serovars frequently isolated from retail chickens and were reported to be isolated in Turkey. In this study, the role of plasmids carried by S.Kentucky and S.Infantis isolates in antibiotic resistance profiles of the isolates and their pathogenicity on Caenorhabditis elegans nematode model system were investigated. The isolates used, 1 of Kentucky and 2 of Infantis serotypes, were selected among food-borne Salmonella isolated from chicken carcass in Edirne...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29624892/antibiotic-mediated-bacteriome-depletion-in-apc-min-mice-is-associated-with-reduction-in-mucus-producing-goblet-cells-and-increased-colorectal-cancer-progression
#14
Kamaljeet Kaur, Arpit Saxena, Irina Debnath, Jacqueline L O'Brien, Nadim J Ajami, Thomas A Auchtung, Joseph F Petrosino, Alexander-Jacques Sougiannis, Sarah Depaep, Alexander Chumanevich, Phani M Gummadidala, Mayomi H Omebeyinje, Sourav Banerjee, Ioulia Chatzistamou, Paramita Chakraborty, Raja Fayad, Franklin G Berger, James A Carson, Anindya Chanda
Recent epidemiological evidence suggests that exposure to antibiotics in early-to-middle adulthood is associated with an increased risk of colorectal adenoma. However, mechanistic studies in established preclinical cancer to examine these claims are extremely limited. Therefore, we investigated the effect of long-term exposure of an antibiotic cocktail composed of Vancomycin, Neomycin, and Streptomycin, on tumor development and progression in the ApcMin/+ mouse, an established genetic model for familial adenomatous polyposis...
April 6, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29619335/role-of-neomycin-polymyxin-sulfate-solution-bladder-wash-for-prevention-of-catheter-associated-urinary-tract-infection-in-traumatic-brain-injury-patient-admitted-to-intensive-care-unit-a-prospective-randomized-study
#15
Neeraj Kumar, Yashpal Singh, Ghanshyam Yadav, S K Mathur, Umesh Kumar Bhadani
Background: Catheter - associated urinary tract infection (CAUTI) remains a critical threat for patients in intensive care unit especially in traumatic brain injury patients with low Glasgow coma score (GCS). Almost all patients in ICU receive antibiotic either prophylactic or therapeutic based on local antibiogram of particular ICU or hospital. For prophylaxis, systemic antibiotics are used. It will be helpful to avoid systemic side effects by introducing antibiotics locally through bladder irrigation...
January 2018: International Journal of Critical Illness and Injury Science
https://www.readbyqxmd.com/read/29615253/antimicrobial-susceptibility-of-haemophilus-parasuis-isolates-from-germany-by-use-of-a-proposed-standard-method-for-harmonized-testing
#16
Sandra Brogden, Andrea Pavlović, Regina Tegeler, Heike Kaspar, Nicole De Vaan, Corinna Kehrenberg
Haemophilus parasuis-related infections, especially among weaners are responsible for major economic losses on pig farms. A method for broth microdilution susceptibility testing of this fastidious organism has recently been developed, but the suitability of this method needs to be validated in a large collection of current field isolates. Using the proposed method, this study tested 123 H. parasuis isolates from different geographic regions in Germany (including five isolates from the Netherlands and Belgium) against a panel of 24 antimicrobial agents and antimicrobial combinations...
April 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29610582/the-samhd1-mediated-block-of-line-1-retroelements-is-regulated-by-phosphorylation
#17
Alexandra Herrmann, Sabine Wittmann, Dominique Thomas, Caitlin N Shepard, Baek Kim, Nerea Ferreirós, Thomas Gramberg
Background: The restriction factor SAMHD1 regulates intracellular nucleotide level by degrading dNTPs and blocks the replication of retroviruses and DNA viruses in non-cycling cells, like macrophages or dendritic cells. In patients, inactivating mutations in samhd1 are associated with the autoimmune disease Aicardi-Goutières Syndrome (AGS). The accumulation of intracellular nucleic acids derived from endogenous retroelements thriving in the absence of SAMHD1 has been discussed as potential trigger of the autoimmune reaction...
2018: Mobile DNA
https://www.readbyqxmd.com/read/29594367/a-sers-based-multiple-immuno-nanoprobe-for-ultrasensitive-detection-of-neomycin-and-quinolone-antibiotics-via-a-lateral-flow-assay
#18
Qiaoqiao Shi, Jie Huang, Yaning Sun, Ruiguang Deng, Man Teng, Qingmei Li, Yanyan Yang, Xiaofei Hu, Zhijun Zhang, Gaiping Zhang
The authors describe an ultrasensitive method for simultaneous detection of neomycin (NEO) and quinolones antibiotics (QNS). It is based on the use of (a) two immuno-nanoprobes (a probe for NEO and a probe for QNS), (b) surface-enhanced Raman scattering (SERS) detection, and (c), a portable lateral flow assay (LFA). The two probes consist of gold nanoparticles (AuNPs) conjugated to the Raman active molecule 4-aminothiophenol (PATP), and to monoclonal antibody against NEO (NEO mAb) or against NOR (NOR mAb). Quantitative detection of NEO and QNS was realized via SERS of the PATP-coated AuNPs captured in the test line of a LFA...
January 6, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29587485/wnt-signaling-activates-tigar-and-protects-against-cisplatin-induced-spiral-ganglion-neuron-damage-in-the-mouse-cochlea
#19
Wenwen Liu, Xiaochen Xu, Zhaomin Fan, Gaoying Sun, Yuechen Han, Daogong Zhang, Lei Xu, Mingming Wang, Xue Wang, Shasha Zhang, Mingliang Tang, Jianfeng Li, Renjie Chai, Haibo Wang
AIMS: Cisplatin can damage spiral ganglion neurons (SGNs) and cause sensorineural hearing loss. Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea, but the role of Wnt signaling in protecting SGNs from cisplatin treatment has not yet been elucidated. This study was designed to investigate the neuroprotective effects of Wnt signaling against cisplatin-induced SGN damage. RESULTS: Firstly, we found that Wnt signaling was activated in SGNs after cisplatin treatment...
March 27, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29581909/mechanically-induced-ca-2-oscillations-in-osteocytes-release-extracellular-vesicles-and-enhance-bone-formation
#20
Andrea E Morrell, Genevieve N Brown, Samuel T Robinson, Rachel L Sattler, Andrew D Baik, Gehua Zhen, Xu Cao, Lynda F Bonewald, Weiyang Jin, Lance C Kam, X Edward Guo
The vast osteocytic network is believed to orchestrate bone metabolic activity in response to mechanical stimuli through production of sclerostin, RANKL, and osteoprotegerin (OPG). However, the mechanisms of osteocyte mechanotransduction remain poorly understood. We've previously shown that osteocyte mechanosensitivity is encoded through unique intracellular calcium (Ca2+ ) dynamics. Here, by simultaneously monitoring Ca2+ and actin dynamics in single cells exposed to fluid shear flow, we detected actin network contractions immediately upon onset of flow-induced Ca2+ transients, which were facilitated by smooth muscle myosin and further confirmed in native osteocytes ex vivo...
2018: Bone Research
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