Elli Mylona, Lisa Hefele, Nga Tran Vu Thieu, Tan Trinh Van, Chau Nguyen Ngoc Minh, Anh Tran Tuan, Abhilasha Karkey, Sabina Dongol, Buddha Basnyat, Phat Voong Vinh, Thanh Ho Ngoc Dan, Paula Russell, Richelle C Charles, Christopher M Parry, Stephen Baker
BACKGROUND: Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi A, is a major public health problem in low and middle-income countries. Moderate sensitivity and scalability of current methods likely underestimate enteric fever burden. Determining the serological responses to organism-specific antigens may improve incidence measures. METHODS: Plasma samples were collected from blood culture-confirmed enteric fever patients, blood culture-negative febrile patients over the course of three months and afebrile community controls...
July 5, 2023: Journal of Infectious Diseases