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https://www.readbyqxmd.com/read/25694077/benzo-and-thienobenzo-diazepines-multi-target-drugs-for-cns-disorders
#1
REVIEW
F J B Mendonça Júnior, L Scotti, H Ishiki, S P S Botelho, M S Da Silva, M T Scotti
Benzodiazepines (BZ or BZD) are a class of gabaminergic psychoactive chemicals used in hypnotics, sedation, in the treatment of anxiety, and in other CNS disorders. These drugs include alprazolam (Xanax), diazepam (Valium), clonazepam (Klonopin), and others. There are two distinct types of pharmacological binding sites for benzodiazepines in the brain (BZ1 and BZ2), these sites are on GABA-A receptors, and are classified as short, intermediate, or long-acting. From the thienobenzodiazepine class (TBZ), Olanzapine (2-methyl-4-(4-methyl-l-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine) (Zyprexa) was used as an example to demonstrate the antagonism of this class of compounds for multiples receptors including: dopamine D1-D5, α-adrenoreceptor, histamine H1, muscarinic M1-M5 and 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3 and 5-HT6 receptors...
2015: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/24408594/last-chance-at-grandchildren-a-request-for-perimortem-sperm-harvesting
#2
(no author information available yet)
No abstract text is available yet for this article.
January 2014: Hastings Center Report
https://www.readbyqxmd.com/read/21667885/drug-therapies-for-tardive-dyskinesia-part-2
#3
REVIEW
Robert H Howland
Tardive dyskinesia (TD) is a serious complication associated with the long-term use of dopamine receptor-blocking drugs. No drugs are approved by the U.S. Food and Drug Administration for treating TD. A number of drugs appear to have some benefit for its treatment, including branched-chain amino acids, piracetam (Nootropil(®), Nootrop(®), Nootropyl(®)), clonazepam (Klonopin(®)), levetiracetam (Keppra(®)), propranolol (Inderal(®)), and clonidine (Catapres(®)), and they would be clinically reasonable to try...
July 2011: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/20413800/dissolving-oral-clonazepam-wafers-in-the-acute-treatment-of-prolonged-seizures
#4
COMPARATIVE STUDY
Matthew M Troester, Eric V Hastriter, Yu-Tze Ng
Klonopin (clonazepam; Genentech Inc, South San Francisco, California) oral wafers are benzodiazepines with anticonvulsive and anxiolytic properties. Our institution has been prescribing clonazepam wafers for acute treatment of prolonged seizures for years. Patients' size determined dosing at 0.25, 0.5, 1, or 2 mg wafers. We proceeded to obtain evidence for efficacy. Hospital Institutional Review Board approval was obtained for anonymous patient survey. All children who had been prescribed clonazepam wafers over a 6-year period at our institution were mailed detailed questionnaires...
December 2010: Journal of Child Neurology
https://www.readbyqxmd.com/read/19081798/pills-thrills-and-bellyaches-case-studies-of-prescription-pill-use-and-misuse-among-marijuana-blunt-smoking-middle-class-young-women
#5
Flutura Bardhi, Stephen J Sifaneck, Bruce D Johnson, Eloise Dunlap
Recent survey research has documented important increases during the 2000s in the misuse and abuse of several prescription drugs (Vicodin, Percocet, Codeine, Dilaudid, Xanax, Klonopin, Valium, Ativan, Adderall, Ritalin, among others). This article focuses upon the patterns of pill use and misuse among young women who are middle-class white and college-educated, and they are also experienced marijuana users who report recreational consumption of other illegal drugs. The ethnographic data provides insights about various ways and reasons that such prescription pill misuse occurs among 12 college-educated, (upper) middle-class, white/Asian women in their 20s who were involved in a major ethnographic study of marijuana and blunts...
2007: Contemporary Drug Problems
https://www.readbyqxmd.com/read/16809012/extraction-and-analysis-of-clonazepam-and-7-aminoclonazepam-in-whole-blood-using-a-dual-internal-standard-methodology
#6
Jeffery Hackett, Albert A Elian
In this paper, a simple and robust method for the determination of clonazepam and its primary metabolite (7-aminoclonazepam) in whole blood is described. Clonazepam (klonopin) is a popular prescription drug that has been implicated in the field of drug facilitated sexual assaults (DFSA). Clonazepam, 7-aminoclonazepam and the internal standards (deuterated analogues for GC-MS analysis and nitrazepam for analysis by LC-PDA/GC-MS) were spiked into blood samples. The samples were buffered with a pH 6-phosphate solution (5 mL) and extracted from phenyl spe columns...
March 2, 2007: Forensic Science International
https://www.readbyqxmd.com/read/15329832/clonazepam-use-in-pregnancy-and-the-risk-of-malformations
#7
Angela E Lin, Allyson J Peller, Marie-Noel Westgate, Kara Houde, Aleda Franz, Lewis B Holmes
BACKGROUND: Clonazepam (Klonopin) is a benzodiazepine that has been used widely to treat seizures and conditions such as panic attacks and anxiety disorder. However, the current findings about its use in pregnancy are derived from limited studies of small sample size. Because it is commonly prescribed during pregnancy, more information about its safety is needed. METHODS: The medical records of 28,565 infants were surveyed as part of a hospital-based malformation surveillance program to identify those who had been exposed prenatally to an anticonvulsant, including clonazepam...
August 2004: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/15101879/clonazepam-open-clinical-treatment-trial-for-myofascial-syndrome-associated-chronic-pain
#8
D A Fishbain, R B Cutler, H L Rosomoff, R S Rosomoff
OBJECTIVE: A number of case reports and nonplacebo controlled studies have documented the efficacy of clonazepam (Klonopin) in the treatment of a number of chronic pain syndromes including lancinating and neuropathic/deafferentation pain. There are, however, no data on the efficacy of clonazepam for chronic pain (CP) associated with myofascial pain syndrome (MFPS). Therefore, we wish to report the results of an open clinical treatment trial of clonazepam for CP associated with MFPS. DESIGN: Forty-six patients with chronic pain (PWCP) and a diagnosis of MFPS were recruited into a clonazepam pain treatment open clinical trial...
December 2000: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/12845398/elimination-of-7-aminoclonazepam-in-urine-after-a-single-dose-of-clonazepam
#9
Adam Negrusz, Andrew M Bowen, Christine M Moore, Sheila M Dowd, Mary Jane Strong, Philip G Janicak
The objective of this paper was to determine how long after administration of benzodiazepine clonazepam (CLO), its major metabolite 7-aminoclonazepam (7-ACLO) could be detected in urine collected from 10 healthy volunteers who received a single 3-mg dose of Klonopin (clonazepam). Such data would be of great importance to law enforcement agencies trying to determine the best time interval for urine collection from a victim of drug-facilitated sexual assault in order to reveal drug use. A highly sensitive NCI-GC-MS method for the simultaneous quantitation of CLO and its major metabolite 7-ACLO in urine was developed and validated...
August 2003: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/12423002/deposition-of-7-aminoclonazepam-and-clonazepam-in-hair-following-a-single-dose-of-klonopin
#10
Adam Negrusz, Andrew M Bowen, Christine M Moore, Sheila M Dowd, Mary Jane Strong, Philip G Janicak
The objective of this paper was to determine whether benzodiazepine clonazepam (CLO) and its major metabolite 7-aminoclonazepam (7-ACLO) could be detected in hair collected from healthy volunteers after receiving a single 3-mg dose of Klonopin (clonazepam). Such data would be of great importance to law enforcement agencies trying to determine the best time interval for hair collection from a victim of drug-facilitated sexual assault (DFSA) in order to reveal drug use. Ten healthy volunteers (6 women and 4 men, 23-49 years old) participated in the study...
October 2002: Journal of Analytical Toxicology
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